ライフサイエンスコーパス: endolysosomal

1 ated protein aggregates, lipofuscinosis, and endolysosomal abnormalities.

2 Endolysosomal acidification and the endosomal transporte

3 betaA3/A1-crystallin is essential for normal endolysosomal acidification, and thereby, normal activat

4 ocytes restored V-ATPase activity and normal endolysosomal acidification, thereby increasing the leve

5 iving from NAAD, produced by newly described endolysosomal activities of NA phosphoribosyltransferase

6 The resulting endolysosomal alkalization impedes macrophage antigen pr

7 ing brain homeostasis, as dysfunction of the endolysosomal and autophagic pathways has been associate

8 gnized early neuropathologic features in the endolysosomal and autophagy systems of neurons, includin

9 associated defects in RAB7L1 or LRRK2 led to endolysosomal and Golgi apparatus sorting defects and de

10 d in pigment cells, localizes exclusively to endolysosomal and melanosomal membranes unlike most G pr

11 resentation on MHC-II involve both classical endolysosomal and nonclassical cytosolic pathways.

12 Here, we identify an endolysosomal ATP-sensitive Na(+) channel (lysoNa(ATP)).

13 n mutations in the ATP13A2 gene encoding the endolysosomal ATPase ATP13A2.

14 AF(+) microglia showed overrepresentation of endolysosomal, autophagic, catabolic, and mTOR-related p

15 ll (endoplasmic reticulum, mitochondria, and endolysosomal-autophagy system), and that disorders in t

16 ts underscore the importance of misregulated endolysosomal biogenesis in Wnt signaling and cancer.

17 us to examine the relationship between MITF, endolysosomal biogenesis, and Wnt signaling.

18 nal delivery, microvillus morphogenesis, and endolysosomal biogenesis.

19 -1-induced Ca(2+) response is abolished upon endolysosomal but not Golgi disruption.

20 omal membrane fusion involving P2X4-mediated endolysosomal Ca(2+) release and subsequent CaM activati

21 However, the molecular mechanisms for intra-endolysosomal Ca(2+) release and the downstream Ca(2+) t

22 Intra-endolysosomal Ca(2+) release is required for endolysosom

23 here that NAADP-mediated Ca(2+) release from endolysosomal Ca(2+) stores activates inward membrane cu

24 ly releases Ca(2+) from acidic intracellular endolysosomal Ca(2+) stores.

25 in A1, indicating Ca(2+) release from acidic endolysosomal Ca(2+) stores.

26 esults indicate an essential role of TPC1 in endolysosomal Ca(2+) uptake and filling of endoplasmic r

27 cellular sphingosine and subsequently caused endolysosomal calcium accumulation, which in turn led to

28 ilic drugs (CADs), this mechanism led to the endolysosomal calcium as a critical target for developme

29 radation of Ags is performed by pH-dependent endolysosomal cathepsins.

30 protein (TbMLP) orthologous to the mammalian endolysosomal cation channel Mucolipin 1.

31 Two-pore channels (TPCs) are endolysosomal cation channels.

32 Thus, the membrane organization of endolysosomal CD38, a signal-mediated transport system f

33 have identified two-pore channels (TPCs) as endolysosomal channels that are regulated by NAADP; howe

34 We conclude that the endolysosomal channels TPC1 and TPC2 are essential for a

35 es, lysosomal dysfunction due to loss of the endolysosomal Cl(-) transporter ClC-b/CLCN7 delayed degr

36 Endolysosomal CLC Cl(-)/H(+) exchangers function as elec

37 Trafficking of TLR3 to the endolysosomal compartment arising from fusion of late en

38 ion and exocytosis, as well as regulation of endolysosomal compartment identity.

39 The host endolysosomal compartment is often manipulated by intrac

40 Leakiness of the endolysosomal compartment significantly enhanced prion-l

41 ls provides access of extracellular AA to an endolysosomal compartment to sustain activation of the m

42 er, similar to SIDT2, SIDT1 localizes to the endolysosomal compartment, interacts with the long dsRNA

43 MP3) and LAMP1 indicating enhancement of the endolysosomal compartment.

44 artment that fuses with lysosome to form the endolysosomal compartment.

45 embrane and associated components within the endolysosomal compartment.

46 s to the Toll-like Receptor (TLR) containing endolysosomal compartment.

47 PIKfyve loss in macrophages causes enlarged endolysosomal compartments and impairs the lysosomal deg

48 rafficking from the endoplasmic reticulum to endolysosomal compartments and its subsequent proteolyti

49 imiting membrane and, to a lesser extent, to endolysosomal compartments by confocal fluorescence and

50 which then prevents the acidification of the endolysosomal compartments by inhibiting vacuolar ATPase

51 ion or block the fusion of autophagosomes to endolysosomal compartments caused an increase in C99 lev

52 Membranes of endolysosomal compartments in macrophages are often dama

53 ath), that localizes to the cell surface and endolysosomal compartments in neurons.

54 Ca(2+) release from endolysosomal compartments is mediated via intracellular

55 Endolysosomal compartments maintain cellular fitness by

56 a molecular connection between the Golgi and endolysosomal compartments to enhance proliferative mTOR

57 nd monocytes, but not basophils, traffics to endolysosomal compartments under steady-state conditions

58 9 traffics from the endoplasmic reticulum to endolysosomal compartments where it is cleaved by reside

59 reased contribution of denatured proteins in endolysosomal compartments, indicating an interaction of

60 y, thereby compromising acidification of the endolysosomal compartments, leading to reduced gamma-sec

61 with protein degradation occurring in acidic endolysosomal compartments.

62 ent cells, leading to GLUT1 mis-sorting into endolysosomal compartments.

63 fective exocytosis and impaired integrity of endolysosomal compartments.

64 implement a manual patch-clamp technique for endolysosomal compartments.

65 by increasing the APP/BACE-1 convergence in endolysosomal compartments.

66 e degradation of APP C-terminal fragments in endolysosomal compartments.

67 heckpoints that restrict their activation to endolysosomal compartments.

68 en 1), indicating a lack of integrity in the endolysosomal compartments.

69 fragments with the gold nanoparticles in the endolysosomal compartments.

70 ran, a bulk-endocytosis marker, and with the endolysosomal compartments.

71 eceptor 9 (TLR9) recognizes microbial DNA in endolysosomal compartments.

72 uptake and/or entrapment and degradation in endolysosomal compartments.

73 rts TLRs from the early endosome to the late endolysosomal compartments.

74 asitophorous vacuole (PV) that acquires host endolysosomal components.

75 wever, the biological significance of excess endolysosomal Cu accumulation has not been assessed.

76 HIV PIs modified endolysosomal degradation and epitope production of prot

77 terms of IgE binding, structural stability, endolysosomal degradation and subsequent peptide generat

78 inding and internalization as well as faster endolysosomal degradation compared with Bet v 1.

79 Endolysosomal degradation experiments demonstrated diffe

80 Endolysosomal degradation of Bet v 1 and Mal d 1 resulte

81 rface binding and the kinetics of uptake and endolysosomal degradation of Bet v 1, Api g 1, and Mal d

82 onine starvation greatly reduced Wnt-induced endolysosomal degradation of extracellular serum protein

83 Beclin 2 is required for ligand-induced endolysosomal degradation of several G protein-coupled r

84 al proteases (cathepsins) mitigates the fast endolysosomal degradation of the MOG40-48 core epitope.

85 aluate the possible relationship between the endolysosomal degradation pathway and autophagy on the p

86 bial virulence factors; however, the role of endolysosomal degradation pathways in these processes is

87 l stability of different tropomyosins, their endolysosomal degradation patterns, and T-cell reactivit

88 ays, supporting the hypothesis that impaired endolysosomal degradation underlies the pathogenesis of

89 Endolysosomal degradation was simulated in vitro by usin

90 ell-activating region, low susceptibility to endolysosomal degradation, and induction of a Bet v 1-in

91 2, interacts with KSHV GPCR, facilitates its endolysosomal degradation, and inhibits vGPCR-driven onc

92 ) 44 degrees C) elicited similar patterns of endolysosomal degradation, but not Bla g 7 (T(m) 63 degr

93 Resulting from perturbed endolysosomal degradation, Plaa mutant neurons accumulat

94 h Dau c 1 was still detectable after 48 h of endolysosomal degradation.

95 nic effects of KSHV GPCR by facilitating its endolysosomal degradation.

96 eutralizing antibodies and ability to escape endolysosomal degradation.

97 ar vesicular trafficking pathways, including endolysosomal degradative events such as epidermal growt

98 of activated cell surface receptors via the endolysosomal degradative pathway.

99 ospholipid vesicles and gastrointestinal and endolysosomal digestions in the presence or absence of l

100 t can be turned on by redox activation after endolysosomal disruption and delivery into the cytosol,

101 nown, however, about the role of DNase II in endolysosomal DNA sensing by TLR9.

102 To identify genes governing endolysosomal dynamics, we conducted a global fluorescen

103 Our findings indicate that endolysosomal dysfunction and abnormalities of alpha-syn

104 atic to a disease-specific state that causes endolysosomal dysfunction and neurodegeneration in mice.

105 tools to study aberrant lipid metabolism of endolysosomal dysfunction associated with AD.

106 To further explore how endolysosomal dysfunction causes PD-related neurodegener

107 st common PD-causing LRRK2 mutation, linking endolysosomal dysfunction to the pathogenesis of LRRK2-m

108 retromer insufficiency triggers progressive endolysosomal dysfunction, with ultrastructural evidence

109 lein-independent neurotoxicity consequent to endolysosomal dysfunction.

110 rectly linked to retromer and others causing endolysosomal dysfunction.

111 lic consequences of Complex I inhibition and endolysosomal effects of imiquimod might also contribute

112 a more systemic view that includes the host endolysosomal enzymes.

113 CRISPR/Cas9 cassettes but also controls the endolysosomal escape and payloads release through photot

114 ways on" reporter and subcellular imaging of endolysosomal escape by confocal microscopy.

115 Together, these findings suggest that endolysosomal escape is a critical step in tau propagati

116 for the investigation of new strategies for endolysosomal escape of biomacromolecules to facilitate

117 capsids before and after pH shift exhibited endolysosomal escape.

118 me that intracellular endothelin-1 activates endolysosomal ET(B) receptors and increase cytosolic Ca(

119 ndothelin-1 acts in an intracrine fashion on endolysosomal ET(B) to induce nitric oxide formation, th

120 Both proteins were digested by endolysosomal extracts of mdDC.

121 Bet v 1 was digested with neutrophilic endolysosomal extracts, and the resulting fragments were

122 All proteins were digested with endolysosomal extracts, and the resulting peptides were

123 y that couples the cell's metabolic state to endolysosomal function and are crucial for physical endu

124 hotrexate treatment was sufficient to rescue endolysosomal function and Wnt signaling.

125 ease, all 13 of NCL's causative genes affect endolysosomal function, and at least four have been dire

126 eins involved in translation, secretion, and endolysosomal function.

127 egulator of lysosomes, leading to diminished endolysosomal function.

128 nsient, and after resealing of the membrane, endolysosomal fusion continued.

129 Secretory and endolysosomal fusion events are driven by SNAREs and cof

130 intracellular Na(+) channels able to control endolysosomal fusion, a key process in autophagic flux.

131 re not synonymous, even in the context of an endolysosomal genetic defect linked to Parkinsonism, and

132 mplex 1 (TORC1) control the integrity of the endolysosomal homeostasis and cellular metabolism.

133 er, this work indicates that LRRK2 regulates endolysosomal homeostasis by controlling the balance bet

134 tophagic vesicle accumulation and influences endolysosomal homeostasis.

135 Similar to TLR11, TLR12 is an endolysosomal innate immune receptor that colocalizes an

136 These findings reveal a role for endolysosomal integrity in blocking tau propagation.

137 es and intact lysosomes and thereby preserve endolysosomal integrity.

138 miR-204-mediated regulation of autophagy and endolysosomal interaction as a critical determinant of n

139 Moreover, the primary endolysosomal ion is Na(+), not K(+), as had been previo

140 Earlier work demonstrated that the endolysosomal lipid PI(3,5)P2 activates V-ATPases contai

141 ned from these studies that perturbations in endolysosomal, lipid metabolism, and immune response pat

142 Endolysosomal localization and cleavage of intracellular

143 the sequential recruitment of early and late endolysosomal markers to the elongating tPCs.

144 the Legionella-containing vacuole away from endolysosomal maturation pathways.

145 e GPVI-mediated Rab7 S72 phosphorylation and endolysosomal maturation were blocked by TAK1 inhibition

146 l phagocytes, macrophages are susceptible to endolysosomal membrane damage inflicted by the pathogens

147 lly control PI conversion in endocytosis and endolysosomal membrane dynamics during endosome maturati

148 te [PtdIns(3,5)P2] and for the regulation of endolysosomal membrane dynamics in mammals.

149 a thus suggest a new molecular mechanism for endolysosomal membrane fusion involving P2X4-mediated en

150 endolysosomal Ca(2+) release is required for endolysosomal membrane fusion with intracellular organel

151 sistent with a role for the ESCRT pathway in endolysosomal membrane repair.

152 by the CUE domain promotes Vps9 function in endolysosomal membrane trafficking via promotion of loca

153 rescues the G2019S LRRK2-mediated effects on endolysosomal membrane trafficking.

154 P2X4 and calmodulin (CaM) form a complex at endolysosomal membrane where P2X4 activation recruits Ca

155 , measurement of channel currents across the endolysosomal membrane), including control experiments,

156 Cs) are cation-permeable channels located on endolysosomal membranes and important mediators of intra

157 ncoding these proteins also causes damage to endolysosomal membranes, consistent with a role for the

158 ciated with impaired activation of mTORC1 at endolysosomal membranes, the accumulation of the mannose

159 cies-mediated rupture of the photosensitised endolysosomal membranes, the spatio-temporal selectivity

160 Found in vacuolar or endolysosomal membranes, they regulate the conductance o

161 T) using a photosensitiser that localises in endolysosomal membranes.

162 o compromised retromer-mediated recycling of endolysosomal membranes.

163 y the long Irgm1 isoforms can be detected on endolysosomal membranes.

164 that maintains or restores the integrity of endolysosomal membranes.

165 ncoating ensues coincident with breaching of endolysosomal membranes.

166 lease from acidic-like Ca(2+) stores via the endolysosomal NAADP-sensitive two-pore channels.

167 e proteomic microenvironment of the neuronal endolysosomal network by knocking in (KI) an engineered

168 on mast cells, a cell type unusually rich in endolysosomal organelles (secretory granules).

169 ught to take place at the cell surface or in endolysosomal organelles.

170 bilizing messenger that releases Ca(2+) from endolysosomal organelles.

171 l activities and characteristics in isolated endolysosomal organelles.

172 t lysosomal trafficking regulator Lyst links endolysosomal organization to the selective control of t

173 at were positive for LAMP2, confirming their endolysosomal origin.

174 verexpression of P2X4, as well as increasing endolysosomal P2X4 activity by alkalinization of endolys

175 Previously, we demonstrated that endolysosomal P2X4 forms channels activated by luminal a

176 from WT and polymorphic variant carriers for endolysosomal patch-clamp experimentation to confirm key

177 In contrast to the alternatively used planar endolysosomal patch-clamp technique, this method is a vi

178 The development of endolysosomal patch-clamp techniques has made it possibl

179 mmals has been considered to function in the endolysosomal pathway and in the biosynthetic pathway on

180 lar NTHI avoids, escapes, or neutralizes the endolysosomal pathway and persists within human respirat

181 Chlamydial inclusions are uncoupled from the endolysosomal pathway and undergo fusion with cellular o

182 ae that regulate membrane trafficking in the endolysosomal pathway by activating Rab5 GTPases.

183 srupt phosphoinositide homeostasis along the endolysosomal pathway causing dysfunction of the cells l

184 rnover of synaptic membrane proteins via the endolysosomal pathway is essential for synaptic function

185 lular homeostasis over a lifetime, where the endolysosomal pathway plays a prominent role by regulati

186 Maturation of organelles in the endolysosomal pathway requires exchange of the early end

187 otein-(APP) cleaving enzyme (BACE1) from the endolysosomal pathway to recycling endosomes represents

188 t manner, is subsequently trafficked via the endolysosomal pathway, and is killed in lysosomes after

189 n a trafficking defect of two cargoes of the endolysosomal pathway, influenza A virus (IAV) and epide

190 its of the retromer, Rh1 is processed in the endolysosomal pathway, leading to a dramatic increase in

191 By targeting CalipHluor to the endolysosomal pathway, we mapped lumenal Ca(2+) changes

192 d that pffs are rapidly trafficked along the endolysosomal pathway, where most of the material remain

193 gned to localize within organelles along the endolysosomal pathway.

194 TrCP ubiquitin E3 ligase and occurred via an endolysosomal pathway.

195 pool size by enhancing SV trafficking to the endolysosomal pathway.

196 in targeted HIV-1 Gag for degradation by the endolysosomal pathway.

197 radation by lysosomes and trafficking in the endolysosomal pathway.

198 the degradation of endocytic cargoes by the endolysosomal pathway.

199 in-modified cargoes are sequestered into the endolysosomal pathway.

200 esponsible for recycling proteins within the endolysosomal pathway.

201 ucer cell membrane through an AP-2-dependent endolysosomal pathway.

202 AR10), is an interorganelle regulator of the endolysosomal pathway.

203 nes and leads to RhoB degradation through an endolysosomal pathway.

204 ous C9ORF72 gene product, which functions in endolysosomal pathways and suppresses systemic and neura

205 Current studies suggest that autophagy-endolysosomal pathways are critical for HD pathology.

206 data identify Vps34 as a major regulator of endolysosomal pathways in podocytes and underline the fu

207 mport through transmembrane transporters and endolysosomal pathways.

208 fundamental question: are SVs sorted toward endolysosomal pathways?

209 Here we show that endolysosomal pH is critical for receptor sorting and tu

210 TLR9 regulates the assembly of the endolysosomal phosphatidylinositol 3-kinase complex (PI3

211 birch pollen-derived molecules influence the endolysosomal processing of Bet v 1, thereby shaping its

212 It was also shown that altered expression of endolysosomal proteases (cathepsins) mitigates the fast

213 analysis of Bet v 1 processing by individual endolysosomal proteases as well as the T-cell epitope pr

214 etics and preferential cleavage sites of the endolysosomal proteases cathepsin S and legumain.

215 Here, we identify the cathepsin L/B endolysosomal proteases functioning in a direct and rate

216 Dau c 1 was incubated with endolysosomal proteases, and the resulting fragments wer

217 These findings demonstrate that sorting of endolysosomal proteins begins at an earlier stage and in

218 r a different mechanism in which two sets of endolysosomal proteins undergo early segregation to dist

219 impeding binding of the C-loop of NPC1, the endolysosomal receptor for EBOV.

220 ected against proteolytic degradation by the endolysosomal serine protease cathepsin G.

221 This protection requires the vacuolar/endolysosomal signaling lipid PI3,5P2 We show that Pho85

222 eutrophil extracellular trap production, and endolysosomal signaling.

223 e used snapin mutants as tools to assess how endolysosomal sorting and trafficking impact presynaptic

224 containing protein 1 (UBXD1) cofactor during endolysosomal sorting of caveolin-1.

225 : the biogenesis of multivesicular bodies in endolysosomal sorting; the budding of HIV-1 and other vi

226 sensitive, presumably arising from different endolysosomal sources.

227 common pathogenic mechanisms associated with endolysosomal storage disorders.

228 PC2, but not TPC1, caused a proliferation of endolysosomal structures, dysregulating intracellular tr

229 significantly enriched for components of the endolysosomal system (>60%, P < 0.001) and included many

230 trafficking and degradative functions of the endolysosomal system are known to be critical for the fu

231 CTSD is delivered to the endolysosomal system as an inactive precursor (proCTSD)

232 fied the two-pore channels (TPCs) within the endolysosomal system as NAADP-regulated Ca(2+) channels

233 ng to lysosomes and how pathogens hijack the endolysosomal system during infection.

234 t work has further dissected the role of the endolysosomal system in both bone formation by osteoblas

235 oles of PIs in different compartments of the endolysosomal system in mammalian cells and discuss the

236 g of plasma membrane-derived MAG through the endolysosomal system in primary cells and brain tissue.

237 In addition, Notch trafficking across the endolysosomal system is critical in its regulation.

238 Dysfunction of the endolysosomal system is often associated with neurodegen

239 tive Ca(2+)-permeable cation channels in the endolysosomal system of cells, as candidate targets for

240 Protein recycling through the endolysosomal system relies on molecular assemblies that

241 Transport along the endolysosomal system requires multiple fusion events at

242 The compromised endolysosomal system resulting from AMPK or Tfeb inactiv

243 Organelles of the endolysosomal system undergo multiple fission and fusion

244 e data support a novel signaling axis in the endolysosomal system whereby LRRK2-mediated Rab10 phosph

245 cretory compartments, catabolic steps of the endolysosomal system, and intracellular trafficking.

246 jor mechanism for mobilizing Ca(2+) from the endolysosomal system, resulting in localized Ca(2+) sign

247 cuole is rendered nonfusogenic with the host endolysosomal system.

248 cal roles as Ca(2+) -release channels of the endolysosomal system.

249 ce between pathogenic infection and the host endolysosomal system.

250 hich are required for their targeting to the endolysosomal system.

251 cytes had defects in the organization of the endolysosomal system.

252 tive phenotypes of mutations that affect the endolysosomal system.

253 intracellular ion channels expressed in the endolysosomal system.

254 ficiency of downstream sorting events in the endolysosomal system.

255 iple vesicular trafficking events within the endolysosomal system.

256 l phagocytosis and debris processing via the endolysosomal system.

257 which distribute across the cytosol and the endolysosomal system.

258 omposition and function of organelles of the endolysosomal system.

259 kaging into coated vesicles destined for the endolysosomal system.

260 membrane fusion events in the secretory and endolysosomal systems, and all SNARE-mediated fusion pro

261 Here, we report a novel function of the endolysosomal T. gondii sortilin-like receptor (TgSORTLR

262 VPS41, a component of the endolysosomal tethering homotypic fusion and vacuole pro

263 the lysosome' (TASL), abrogated responses to endolysosomal TLR agonists in both primary and transform

264 ntial but poorly understood component of the endolysosomal TLR machinery also linked to autoimmune di

265 e, a class III lipid kinase, is required for endolysosomal TLR-induced expression of type I IFN in mo

266 fication of TASL as the component that links endolysosomal TLRs to the IRF5 transcription factor via

267 evoked Ca(2+) release or genetic ablation of endolysosomal TPC1 or TPC2 channels attenuates glucose-

268 AB8A mimicked the effects of G2019S LRRK2 on endolysosomal trafficking and decreased RAB7A activity.

269 lysosomal calcium channel TRPML1 to disrupt endolysosomal trafficking and mediate these effects.

270 activity in a manner that is independent of endolysosomal trafficking and parallel to the Scribble m

271 artite regulation of presynaptic activity by endolysosomal trafficking and sorting: LE transport regu

272 ibits Salmonella infection via modulation of endolysosomal trafficking and the vacuolar environment b

273 tablish the importance of ubiquitin-mediated endolysosomal trafficking at the synapse.

274 etic screen, we discovered a large number of endolysosomal trafficking genes required for proper SG m

275 ted multisubunit tethering complexes promote endolysosomal trafficking in all eukaryotes: Rab5-bindin

276 Our data suggest that impaired endolysosomal trafficking in both motor neurons and Schw

277 Moreover, Fig4-regulated endolysosomal trafficking in Schwann cells is essential

278 elles, we hypothesized that BLOC-2-dependent endolysosomal trafficking is essential for WPB biogenesi

279 Although endolysosomal trafficking is well defined, how it is reg

280 Pyk2 depletion resulted in altered endolysosomal trafficking of HPV16 and accelerated unfol

281 role of Cul3 in regulating late steps in the endolysosomal trafficking pathway.

282 re broadly, our data suggest a role for host endolysosomal trafficking pathways in regulating viral p

283 ay of apoptotic signalling and regulation of endolysosomal trafficking resulting in a positive feedba

284 rsity of Beclin family members in autophagy, endolysosomal trafficking, and metabolism.

285 TRPML1 reversed the toxic effects of VacA on endolysosomal trafficking, culminating in the clearance

286 5-bisphosphate, and plays a critical role in endolysosomal trafficking.

287 olae-mediated pathway, bypassing degradative endolysosomal trafficking.

288 unction, pathogenic G2019S LRRK2 deregulates endolysosomal transport and endocytic recycling events.

289 IRG1, RIN3, and RUFY1 all may be involved in endolysosomal transport-a process known to be important

290 dule mutants show intact internalization and endolysosomal transport.

291 lupus erythematosus(4,5)-interacts with the endolysosomal transporter SLC15A4, an essential but poor

292 ATP13A2 (PARK9) is a late endolysosomal transporter that is genetically implicated

293 Conclusion: CC endolysosomal trapping provides a pathway to increase th

294 The endolysosomal two-pore channels (TPCs), TPC1 and TPC2, h

295 ding VAC14, a previously identified cause of endolysosomal vacuolization.

296 eens to identify small molecules that rescue endolysosomal vacuolization.

297 master transcription factor (MITF)-regulated endolysosomal vesicle genes.

298 a patients, restricted transcription of this endolysosomal vesicle pathway is a hallmark of PRL3-high

299 ct evidence that Zn(2+) can be released from endolysosomal vesicles to the cytosol in primary hippoca

300 omplex and/or localization of the complex to endolysosomal vesicles.