ライフサイエンスコーパス: endonucleolytic

1 n this tRNA were tested for their effects on endonucleolytic 3'-end processing and CCA addition at th

2 y inactive mutant of the enzyme showing that endonucleolytic ability of the protein is dispensable fo

3 Endonucleolytic action by AtCPSF30 leaves RNA 3' ends wi

4 ubstitutions at Lys301, which is part of the endonucleolytic active site, eliminate binding to the cl

5 The PI-SceI protein splicing and endonucleolytic active sites are separately located in e

6 At the putative endonucleolytic active sites, the superposition reveals

7 The data reveal that sequence-specific endonucleolytic activities cleave the transforming DNA a

8 We show that WH is able to modulate FEN1's endonucleolytic activities depending on the substrate DN

9 n that tethering of the termini enhances the endonucleolytic activities of integrase.

10 presence of both 5'-to-3' exonucleolytic and endonucleolytic activities on the Bacillus subtilis thrS

11 a negative regulatory effect on the Artemis endonucleolytic activities, and phosphorylation by DNA-P

12 lation sites still retain DNA-PKcs-dependent endonucleolytic activities, indicating that basal phosph

13 city enzyme, with both 5' exonucleolytic and endonucleolytic activities.

14 In addition to known disparities in their endonucleolytic activity [13, 14], the four Ago proteins

15 sequence that can act as a substrate for Rep endonucleolytic activity [terminal resolution site (TRS)

16 e the presence of cysteine proteases for its endonucleolytic activity and that the cysteine proteases

17 ' exonucleolytic activity, as well as robust endonucleolytic activity as compared to its bacterial ho

18 sociates with human FEN-1 and stimulates its endonucleolytic activity at branched DNA structures and

19 n generates a mutant RNase III with impaired endonucleolytic activity but without blocking its abilit

20 Exo III's apurinic endonucleolytic activity differentially processes hybrid

21 apoptotic nuclear collapse requires a 3'-OH endonucleolytic activity even though the internucleosoma

22 virus terminase complex, pUL89, provides the endonucleolytic activity for genome cleavage, and the do

23 ally associated with the upregulation of the endonucleolytic activity herein described.

24 etely inactive in vitro, whereas it exhibits endonucleolytic activity in the context of FL-L-terminas

25 was used to confirm the existence of a weak endonucleolytic activity in the enzyme.

26 and 3'-DNA overhangs of duplex DNA, and this endonucleolytic activity is dependent upon DNA-PKcs.

27 The endonucleolytic activity is inhibited by the nuclease A

28 ucleolytic activity of FEN-1 in terms of its endonucleolytic activity is proposed based on these obse

29 The robust endonucleolytic activity of AtRNase J suggests its invol

30 The endonucleolytic activity of human apurinic/apyrimidinic

31 Gre factors enhance the intrinsic endonucleolytic activity of RNA polymerase to rescue arr

32 otein composition of the degradosome and the endonucleolytic activity of RNase E.

33 In eukaryotes, the endonucleolytic activity of the calf RTH-1 class 5'- to

34 ibly through activation or regulation of the endonucleolytic activity of the N-terminal domain of XPF

35 dent of RelE, and has been proposed to be an endonucleolytic activity of the ribosome.

36 phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5' and 3' overhangs, as well

37 -->3'exodeoxyribonuclease that also exhibits endonucleolytic activity on flap structures (branched du

38 nated with 5' monophosphorylated thrS, while endonucleolytic activity predominated with 5' triphospho

39 Endonucleolytic activity that cleaved HBV RNA at positio

40 extracts prepared from MEL cells contain an endonucleolytic activity that generates decay products c

41 d1 complex, was recently found to possess an endonucleolytic activity that incises on the 5' side of

42 This protein possesses an unexpected endonucleolytic activity that is apparent as an ability

43 , correlating with the predominance of hFEN1 endonucleolytic activity versus hEXO1 exonucleolytic act

44 In soluble extracts, most (80 to 90%) of the endonucleolytic activity was due to RNases I and I*, sin

45 This endonucleolytic activity was inhibited by Zn2+, aurintri

46 The chimeric protein possessed endonucleolytic activity, cleaving both strands of the T

47 Cyclophilins also display endonucleolytic activity, demonstrated by their ability

48 cation, DNA strand separation, and intrinsic endonucleolytic activity.

49 ctivity of Argonaute itself, which often has endonucleolytic activity.

50 nce by binding to RNase E and regulating its endonucleolytic activity.

51 g that XBP-1 mRNA is a direct target of IRE1 endonucleolytic activity.

52 roducts indicates that they are generated by endonucleolytic activity.

53 ase activity or the ability to promote Mre11 endonucleolytic activity.

54 cessing is splicing-independent and requires endonucleolytic activity.

55 o 3' exonucleolytic and a structure-specific endonucleolytic activity.

56 essing of polycistronic pre-snoRNAs involves endonucleolytic activity.

57 an retroposons is mediated by an enzyme with endonucleolytic activity.

58 ent replication, by virtue of intron-encoded endonucleolytic activity.

59 inimal effect on RNase H activity, retaining endonucleolytic and directed cleavage of an RNA/DNA hybr

60 nd repair flap endonucleases (FENs) catalyze endonucleolytic and exonucleolytic (EXO) DNA hydrolyses.

61 Here we show that hMRN catalyzes sequential endonucleolytic and exonucleolytic activities on both 5'

62 ats in the course of replication, relying on endonucleolytic and exonucleolytic activities, respectiv

63 BLM protein stimulates both the endonucleolytic and exonucleolytic cleavage activity of

64 tion center significantly inhibited both the endonucleolytic and exonucleolytic degradation activitie

65 ism for the coordination of the proteolytic, endonucleolytic, and morphogenetic aspects of apoptosis.

66 hen bound to the mRNA, shields the mRNA from endonucleolytic attack and thereby prolongs the mRNA hal

67 that normally protects chromosomal DNA from endonucleolytic attack.

68 es to a single subnuclear focus following an endonucleolytic break.

69 rate anti-RNase E monoclonal antibodies; the endonucleolytic cleavage activity co-purified with the i

70 oth strand and sequence specificities on the endonucleolytic cleavage activity of Orf20.

71 The starvation-induced endonucleolytic cleavage activity targets tRNAs that hav

72 acterial RNA polymerase exhibit an intrinsic endonucleolytic cleavage activity that restores the hybr

73 orts the idea that topo IIIbeta possesses an endonucleolytic cleavage activity.

74 This modulation likely involves endonucleolytic cleavage and a competing interaction wit

75 (A) tail of a mammalian mRNA is generated by endonucleolytic cleavage and poly(A) addition.

76 mRNA fragments generated by endonucleolytic cleavage are most likely removed by exon

77 protein demonstrated a high selectivity for endonucleolytic cleavage at abasic sites in DNA, a prope

78 otein-free and Argonaute 2-loaded miRNAs via endonucleolytic cleavage at CA and UA dinucleotides, pre

79 here that the degradation petD mRNA involves endonucleolytic cleavage at specific sites upstream of t

80 II and gains access to the nascent RNA after endonucleolytic cleavage at the poly(A) site or at a sec

81 whereby the downstream products of RNase J1 endonucleolytic cleavage become substrates for the 5' to

82 or residues were removed from the 3' end by endonucleolytic cleavage before polymerization began.

83 Although the initial endonucleolytic cleavage by definition generates two pro

84 s in translation elongation are targeted for endonucleolytic cleavage by No-Go decay (NGD).

85 Previously, endonucleolytic cleavage by ribonuclease RNase J1 in a 3

86 iphosphate to a monophosphate triggers rapid endonucleolytic cleavage by RNase E.

87 nerate a monophosphate group that stimulates endonucleolytic cleavage by RNase E.

88 Efficient endonucleolytic cleavage by RTH1 nuclease has been demon

89 a catalytic riboswitch that is activated for endonucleolytic cleavage by the coenzyme glucosamine-6-p

90 osome fragmentation, which was distinct from endonucleolytic cleavage commonly associated with apopto

91 ere that 3'-end processing in vitro involves endonucleolytic cleavage downstream from the mature term

92 me-mediated beta-elimination reaction, or by endonucleolytic cleavage downstream of the baseless suga

93 The hMRN endonucleolytic cleavage events are further stimulated b

94 generated from the 3'-extended precursors by endonucleolytic cleavage followed by exonucleolytic trim

95 of most eukaryotic mRNAs are produced by an endonucleolytic cleavage followed by synthesis of a poly

96 quires processing of their 3'UTRs through an endonucleolytic cleavage guided by the U7 snRNA, which i

97 ing of histone pre-mRNA requires a single 3' endonucleolytic cleavage guided by the U7 snRNP that bin

98 degradation in Escherichia coli begins with endonucleolytic cleavage has been challenged by the rece

99 ivity and a potential consensus sequence for endonucleolytic cleavage identified, the structures of t

100 ccharomyces cerevisiae promote site-specific endonucleolytic cleavage in 25S ribosomal RNA (rRNA) adj

101 sults highlight the underappreciated role of endonucleolytic cleavage in controlling mRNA fates in ma

102 Rlp7p may also be required for the endonucleolytic cleavage in internal transcribed spacer

103 In contrast, Nop4, a protein required for endonucleolytic cleavage in ITS1, binds the pre-rRNA nea

104 ort a systematic study of small RNA-mediated endonucleolytic cleavage in mouse through integrative an

105 activity of the exosome is not required for endonucleolytic cleavage in no-go decay.

106 histone genes undergo efficient and faithful endonucleolytic cleavage in nuclear extracts prepared fr

107 This endonucleolytic cleavage is believed to involve the cova

108 Our previous studies demonstrated that the endonucleolytic cleavage is catalyzed by the cleavage/po

109 The mechanism of endonucleolytic cleavage is not consistent with the mech

110 Similar disruption of endonucleolytic cleavage is observed, except for the pla

111 The common belief that endonucleolytic cleavage is the initial, rate-determinin

112 In particular, Ire1p endonucleolytic cleavage leaves 2', 3'-cyclic phosphates

113 which the primer has an unannealed 5'-tail, endonucleolytic cleavage near the annealing point releas

114 The process is characterized by an endonucleolytic cleavage near the stall sequence, but th

115 atalytic subunit (DNA-PKcs) that carries out endonucleolytic cleavage of 5' and 3' overhangs.

116 of blunt-ended duplex DNA substrates and the endonucleolytic cleavage of 5'-bifurcated nucleic acids

117 ine or histidine in lieu of Tyr-274 catalyze endonucleolytic cleavage of a 60 bp duplex DNA at the CC

118 endothelial cells (HUVECs) for the specific endonucleolytic cleavage of a test mRNA to generate capp

119 ologous oligonucleotides that originate from endonucleolytic cleavage of cellular mRNA during the pro

120 ntation during apoptosis is characterized by endonucleolytic cleavage of chromosomal DNA into an olig

121 Such endonucleolytic cleavage of circular double-stranded DNA

122 The endonucleolytic cleavage of circular dsDNA is consistent

123 pAgos were shown to use small DNA guides for endonucleolytic cleavage of complementary DNA in vitro.

124 A conserved response to stress involves endonucleolytic cleavage of cytoplasmic transfer RNAs (t

125 MRN-mediated endonucleolytic cleavage of DNA at sites of protein addu

126 poptosis, as measured by standard assays for endonucleolytic cleavage of DNA.

127 Both pAgos can perform programmable endonucleolytic cleavage of double-stranded DNA substrat

128 us gene, strongly suggest that they arise by endonucleolytic cleavage of endogenous PG mRNA.

129 ects a preferred site of posttranscriptional endonucleolytic cleavage of genomic RNA.

130 tro, the same protein is responsible for the endonucleolytic cleavage of histone pre-mRNA and the sub

131 Following endonucleolytic cleavage of histone pre-mRNA, the downst

132 The enzyme catalyses endonucleolytic cleavage of Holliday junction-containing

133 Endonucleolytic cleavage of Holliday junctions is import

134 on, and it also induces a template-dependent endonucleolytic cleavage of host mRNAs.

135 TerL, following endonucleolytic cleavage of immature viral DNA concateme

136 ion factor, X-box-binding protein 1, through endonucleolytic cleavage of its messenger RNA (mRNA).

137 the fact that most miRNAs are generated from endonucleolytic cleavage of longer transcripts, this fin

138 Endonucleolytic cleavage of mRNA in the daa operon of Es

139 SiRNAs typically induce endonucleolytic cleavage of mRNA with near-perfect compl

140 with the C terminus of Rpb1 and catalyze the endonucleolytic cleavage of nascent snRNAs near their 3'

141 tion of the 3' end of histone mRNA occurs by endonucleolytic cleavage of pre-mRNA releasing the matur

142 x is a group of proteins responsible for the endonucleolytic cleavage of primary small nuclear RNA (s

143 ation for the influence of 5' termini on the endonucleolytic cleavage of primary transcripts, which a

144 roL The terminator fragment derived from the endonucleolytic cleavage of proL transcript is degraded

145 RNA group I intron catalyzes a site-specific endonucleolytic cleavage of RNA, DNA, and chimeric RNA/D

146 ucleotides (PAMmers) stimulate site-specific endonucleolytic cleavage of ssRNA targets, similar to PA

147 miRNAs and other small RNAs that direct endonucleolytic cleavage of target mRNAs produce diagnos

148 n are well appreciated, their involvement in endonucleolytic cleavage of target RNAs is poorly unders

149 lear RNA by PB2, which then usually leads to endonucleolytic cleavage of the capped primer 13 nucleot

150 f Escherichia coli adhesins, is regulated by endonucleolytic cleavage of the daaABCDPE primary transc

151 sibly via a helicase mechanism, and eventual endonucleolytic cleavage of the DNA.

152 be required for a degradation step following endonucleolytic cleavage of the excised lariat.

153 Endonucleolytic cleavage of the nascent pre-mRNA defines

154 reactivates arrested polymerase by inducing endonucleolytic cleavage of the nascent transcript by th

155 is of the majority of snRNAs involves 3' end endonucleolytic cleavage of the nascent transcript from

156 ption by RNA polymerase II is preceded by an endonucleolytic cleavage of the nascent transcript.

157 CPF mediates the endonucleolytic cleavage of the pre-mRNA and addition of

158 ves an enzymatic cascade, initiating with an endonucleolytic cleavage of the pre-mRNA at an editing s

159 U-deletion editing involves endonucleolytic cleavage of the pre-mRNA at the editing

160 The 3' end of histone mRNA is formed by an endonucleolytic cleavage of the primary transcript after

161 did not require ATP, and was accompanied by endonucleolytic cleavage of the resulting 3' overhang.

162 NA strand; however, the structural basis for endonucleolytic cleavage of the RNA strand remains elusi

163 in both flies and mammals, each siRNA guides endonucleolytic cleavage of the target RNA at a single s

164 Thus, the RISC-component that mediates endonucleolytic cleavage of the target RNA remains to be

165 ino acid residues involved in recognition or endonucleolytic cleavage of these diverse substrates.

166 ethylation increases the angiogenin-mediated endonucleolytic cleavage of transfer RNAs (tRNA) leading

167 erved stress response in eukaryotes involves endonucleolytic cleavage of transfer RNAs (tRNAs).

168 let-7 miRNA-induced and Argonaute-catalysed endonucleolytic cleavage on target mRNAs at various site

169 anisms, with little contribution from either endonucleolytic cleavage or deadenylation-independent de

170 c silencing of complementary target mRNAs by endonucleolytic cleavage or translational repression.

171 The RNase P-mediated endonucleolytic cleavage plays a crucial role in the 3'

172 es typically show chromatin condensation and endonucleolytic cleavage prior to obvious membrane or or

173 -rps14 operons revealed other polyadenylated endonucleolytic cleavage products, indicating that poly(

174 Whether its restriction activity involves endonucleolytic cleavage remains unclear.

175 An internal deletion of endonucleolytic cleavage sites previously identified wit

176 lease-deficient cells revealed >103 putative endonucleolytic cleavage sites with single-nucleotide re

177 g affinities, (f) the presence or absence of endonucleolytic cleavage sites, (g) control of intracell

178 two distinct steps; the first is a specific endonucleolytic cleavage step called "processing," and t

179 La cell nuclear extract strongly reduced the endonucleolytic cleavage step of the cleavage and polyad

180 on the assumption that the decay involves an endonucleolytic cleavage that functionally inactivates t

181 one pre-mRNAs are processed at the 3' end by endonucleolytic cleavage that is not followed by polyade

182 iotic DSBs in budding yeast are processed by endonucleolytic cleavage that releases Spo11 attached to

183 nt on tRNAs, where it can protect tRNAs from endonucleolytic cleavage to maintain protein synthesis.

184 pre-tRNAs in conformations that allow the 3' endonucleolytic cleavage to occur.

185 Endonucleolytic cleavage was 5' to the abasic site.

186 First, only few mRNAs that undergo low-level endonucleolytic cleavage were observed, suggesting that

187 hat are perfectly complementary by directing endonucleolytic cleavage where they anneal, thereby trig

188 revents both removal of the poly(A) tail and endonucleolytic cleavage within primary transcripts, but

189 , together with the effect of tail length on endonucleolytic cleavage within primary transcripts, sug

190 RecBCD action is required for stimulating endonucleolytic cleavage within the transpososome-protec

191 The second event (endonucleolytic cleavage) occurs after a variable delay

192 a heterotrimer necessary for the first step, endonucleolytic cleavage, and it plays an important role

193 The 5' extremity of 12S rRNA is generated by endonucleolytic cleavage, and TbDSS-1 degrades resulting

194 e substrates before and after their exo- and endonucleolytic cleavage, as well as structures of uncle

195 ough a series of processing steps, including endonucleolytic cleavage, nuclear export and a strand se

196 ation followed by exonucleolytic decay, mRNA endonucleolytic cleavage, or translational inhibition.

197 d in standard enzymatic reactions (ligation, endonucleolytic cleavage, random labeling, PCR, and cycl

198 n elongation are recognized and targeted for endonucleolytic cleavage, referred to as 'no-go decay'.

199 onal diversity, while Gfh1 inhibits exo- and endonucleolytic cleavage, RNA synthesis, and pyrophospho

200 vo and in vitro models showed no evidence of endonucleolytic cleavage, suggesting that rRNA degradati

201 Mus81-Eme1 complex resolves DNA junctions by endonucleolytic cleavage.

202 bstrates for both exonucleolytic and 5' flap endonucleolytic cleavage.

203 ognizing the stalled ribosome and triggering endonucleolytic cleavage.

204 d pyrophosphorolysis, GreA enhances only the endonucleolytic cleavage.

205 fic and nonspecific polyadenylation and also endonucleolytic cleavage.

206 of this mutant was due to retardation of the endonucleolytic cleavage.

207 migration whereas RuvC resolves junctions by endonucleolytic cleavage.

208 ze c-myc mRNA in vitro by protecting it from endonucleolytic cleavage.

209 ed SoxR in protecting the soxS operator from endonucleolytic cleavage.

210 nsferrin receptor results in protection from endonucleolytic cleavage.

211 anslation at a premature nonsense codon, and endonucleolytic cleavage.

212 ause, backtrack, and are then reactivated by endonucleolytic cleavage.

213 troy complementary transposon transcripts by endonucleolytic cleavage.

214 ut, in contrast to the BTR complex, do so by endonucleolytic cleavage.

215 The editing endonucleolytic cleavages being lost when the editing co

216 Mature miRNAs are produced by two sequential endonucleolytic cleavages facilitated by Drosha in the n

217 patterns in vivo suggesting Rrp44-dependent endonucleolytic cleavages in the 5'-ETS and ITS2 regions

218 tructures did not prevent degradation, rapid endonucleolytic cleavages most likely trigger RNA destru

219 We applied RAMP to examine how endonucleolytic cleavages of the mouse pre-rRNA transcri

220 The endonucleolytic cleavages produced by Orf20 generated a

221 t multiple sites is a prerequisite for three endonucleolytic cleavages that initiate small subunit bi

222 ) that binds to RNase E and inhibits RNase E endonucleolytic cleavages without altering cleavage site

223 icipates in initiating mRNA turnover through endonucleolytic cleavages.

224 y because all its action on 6S RNA is due to endonucleolytic cleavages.

225 rongly accumulated, without affecting normal endonucleolytic cleavages.

226 meiotic double-strand breaks (DSBs) requires endonucleolytic clipping of Rec12(Spo11)-oligonucleotide

227 iated exonucleolytic decay and Cue2-mediated endonucleolytic decay normally constitutes a secondary d

228 osphorylation--IRE1alpha's RNase also causes endonucleolytic decay of many ER-localized mRNAs, includ

229 These results reveal the role of endonucleolytic DNA cleavage in restriction and yet poin

230 Endonucleolytic DNA fragmentation is the common end poin

231 catalyzes 5'-DNA end degradation by stepwise endonucleolytic DNA incisions, followed by exonucleolyti

232 itochondrial gene expression thus depends on endonucleolytic excision of tRNAs.

233 Pre-tRNAs thus require precise endonucleolytic excision.

234 erged from the common ancestor and then two "endonucleolytic" families branched out, separating "blun

235 by 3'-exonucleolytic degradation rather than endonucleolytic fragmentation by RNase E.

236 Here we investigate the endonucleolytic function of Ago2 and other nucleases by

237 We have examined the endonucleolytic function of Mre11 on defined, radiolabel

238 ements and possessed both exonucleolytic and endonucleolytic functions.

239 eased multiple- and single turnover rates of endonucleolytic hydrolysis at near physiological salt co

240 a conserved DNA repair pathway by making an endonucleolytic incision at the 3' side one nucleotide f

241 a conserved DNA repair pathway by making an endonucleolytic incision at the 3'-side 1 nt from a deam

242 cally stimulates both the exonucleolytic and endonucleolytic incision functions of EXO-1.

243 repair of deaminated DNA bases by making an endonucleolytic incision on the 3' side one nucleotide f

244 NA template and, remarkably, proceeded by an endonucleolytic mechanism.

245 ortant counterpoints in our understanding of endonucleolytic mechanisms and of damaged DNA recognitio

246 nsfers and canonical one-metal and two-metal endonucleolytic mechanisms are provided along with possi

247 , the balance between the exonucleolytic and endonucleolytic modes of hydrolysis shifted in favor of

248 oxidative, hydrolytic, and/or 2'-OH-mediated-endonucleolytic modes of scission.

249 termination of the leading ribosome or cause endonucleolytic mRNA cleavage.

250 anding question on the exonucleolytic versus endonucleolytic nature of 16S rRNA maturation.

251 omics data suggested only minimal effects on endonucleolytic nonsense-mediated mRNA decay components,

252 these decay products are the consequence of endonucleolytic or 5'-to-3' exonucleolytic activity is u

253 ation in Escherichia coli employs a one-step endonucleolytic pathway that does not involve any of the

254 The endonucleolytic petD cleavage products can be polyadenyl

255 3 pre-rRNA base-pairing interactions mediate endonucleolytic pre-rRNA cleavages.

256 oly(A) tail removal by RNase E is in fact an endonucleolytic process that is regulated by the phospho

257 monophosphorylated as a result of sequential endonucleolytic processing by Drosha and Dicer from long

258 Endonucleolytic processing by MRN requires a stably boun

259 cts, the downstream product of atpB pre-mRNA endonucleolytic processing cannot be detected, even tran

260 3'-ends of primary transcripts, the sites of endonucleolytic processing in the 3' untranslated and in

261 that MrsC, directly or indirectly, controls endonucleolytic processing of mRNAs that may be independ

262 s to be extended toward the ICL, followed by endonucleolytic processing of the crosslink, lesion bypa

263 ied two polycistronic tRNA transcripts whose endonucleolytic processing was solely dependent on RNase

264 -protein-primed DNA synthesis and subsequent endonucleolytic processing.

265 A termini can be sampled for suitability for endonucleolytic processing.

266 . solfataricus CMR cleaves RNA targets in an endonucleolytic reaction at UA dinucleotides.

267 main structure, and the protein splicing and endonucleolytic reactions are catalyzed by residues in d

268 ow that Zn2+ can serve as a cofactor for the endonucleolytic reactions catalyzed by either the full-l

269 version mediated by Piv and transposition or endonucleolytic reactions catalyzed by enzymes of the re

270 Exonucleolytic and fork-gap-endonucleolytic reactions were also stimulated by the pr

271 t has two size classes, suggesting different endonucleolytic regulatory mechanisms.

272 Endonucleolytic removal of 5'-leader sequences from tRNA

273 RNase P is generally responsible for endonucleolytic removal of a leader sequence of precurso

274 pre-tRNAs, Lhp1p is required for the normal endonucleolytic removal of the 3' trailer sequence.

275 tRNA units within each operon following the endonucleolytic removal of the distal Rho-independent tr

276 er, RNase E is primarily responsible for the endonucleolytic removal of the entire Rho-independent tr

277 es two reactions in vivo: 1) the binding and endonucleolytic removal of the terminal dinucleotides of

278 ceeds in three steps: 3'-end processing, the endonucleolytic removal of the two terminal nucleotides

279 Endonucleolytic ribozymes constitute a class of non-codi

280 obably triggered by its ability to induce an endonucleolytic RNA cleavage, was separable from its tra

281 s a principal intermediate in factor-induced endonucleolytic RNA cleavage.

282 The hairpin ribozyme is a small endonucleolytic RNA motif with potential for targeted RN

283 rom exonucleolytic digestion but facilitates endonucleolytic scission by MRX with a dependence on ATP

284 uimolar production of rRNAs, it requires the endonucleolytic separation of pre-rRNAs to initiate rRNA

285 Minimally, the action of RISC requires the endonucleolytic slicer activity of Argonaute2 (Ago2) dir

286 Here we demonstrate that endonucleolytic slicing of a transcript by the cytosolic

287 d by the ping-pong cycle, which couples Piwi endonucleolytic slicing of target RNAs to biogenesis of

288 to cleave bifurcated, or branched DNA, in an endonucleolytic, structure-specific manner.

289 iption begins, the opposing functions of the endonucleolytic subunit of Integrator, INTS11, and cycli

290 the U(L)89 open reading frame may encode an endonucleolytic subunit of the putative HCMV terminase.

291 Gre-factors, which stimulate an endogenous, endonucleolytic transcript cleavage activity of the RNA

292 ion elongation by stimulating an endogenous, endonucleolytic transcript cleavage activity of the RNA

293 of a small catalytic RNA that catalyses the endonucleolytic transesterification of RNA in a highly s

294 of a small catalytic RNA which catalyses the endonucleolytic transesterification of RNA in a highly s

295 3'-phosphoglycolate or 3'-hydroxyl terminus, endonucleolytic trimming of 2-4 nucleotides from the 3'-

296 not D165N Artemis suggests that the lack of endonucleolytic trimming of DNA ends is the principal ca

297 To examine whether endonucleolytic trimming of terminally blocked DSBs by A

298 unt-ended DNA, and promotes slow and limited endonucleolytic trimming of the 5'-terminal strand, resu

299 e Z, and establishing its biological role in endonucleolytic tRNA 3' end processing.

300 ts, which were designed to probe pathways of endonucleolytic versus exonucleolytic decay, were measur