ライフサイエンスコーパス: endopeptidase

1 ereas Lc-Lys-2 is a gamma-D-glutamyl-L-lysyl endopeptidase.

2 ide substrate indicated that IrCD1 is a true endopeptidase.

3 amoyl-L-alanine amidase and D-alanyl-glycine endopeptidase.

4 s, resulting from CtsB, CtsL, and asparagine endopeptidase.

5 f interaction between the substrate and BoNT endopeptidase.

6 tease 8, matrix metalloprotease 9, or prolyl endopeptidase.

7 n in cjj81176_1105, a putative peptidoglycan endopeptidase.

8 Neprilysin is a zinc-dependent endopeptidase.

9 MPs) and cysteine cathepsins are families of endopeptidases.

10 bifunctional synthase, PBP1A, and different endopeptidases.

11 on are sensitive to elevated activity of the endopeptidases.

12 that shares limited homology with CaaX-type endopeptidases.

13 cally profiling the substrate specificity of endopeptidases.

14 mechanism of their inhibition of asparaginyl endopeptidases.

15 ne proteases primarily comprised of secreted endopeptidases.

16 ld for designing substrates for any group of endopeptidases.

17 specifically form complexes with various PG endopeptidases.

18 ved epitope of each of the Bd3459 and Bd0816 endopeptidases.

19 The universally conserved kinase-associated endopeptidase 1 (Kae1) protein family has established ro

20 Pro-Pro endopeptidase-1 (PPEP-1) is a secreted metalloprotease f

21 g matrix metalloproteases 8 and 9 and prolyl endopeptidase, a serine protease for which we identify a

22 ShyA is a D,d-endopeptidase able to cleave most peptide chain cross-li

23 Imlifidase (IdeS) is an endopeptidase able to degrade circulating IgG that is cu

24 es a homolog of the SagA cell wall-dependent endopeptidase, acquired distinct transposon insertions i

25 ction for cross-link cleavage and that these endopeptidases act in the normal release of peptidoglyca

26 by the addition of lysostaphin, a bacterial endopeptidase active at neutral pH that can substitute f

27 NG1686 contains M23B endopeptidase active sites found in proteins that cleave

28 acid in both the DD-carboxypeptidase and DD-endopeptidase activities of a class C LMM-PBP.

29 he effect on both DD-carboxypeptidase and DD-endopeptidase activities was determined.

30 for both the dd-carboxypeptidase and the 4,3-endopeptidase activities were prepared by multistep synt

31 f the proteins (SpoIIP) has both amidase and endopeptidase activities, such that it removes the stem

32 G1686 possesses both dd-carboxypeptidase and endopeptidase activities.

33 have substantially higher isopeptidase than endopeptidase activities.

34 l enzyme having both dd-carboxypeptidase and endopeptidase activities.

35 PME was separated from the abundant cysteine endopeptidases activities using sequential hydrophobic i

36 onary inflammation through decreasing prolyl endopeptidase activity and AcPGP.

37 Complexation inhibits endopeptidase activity and cell wall decrosslinking in v

38 nicking of BoNT/E significantly enhances its endopeptidase activity and that at the physiological tem

39 s an M23 peptidase that exhibits D-Ala-D-Asp endopeptidase activity and that this activity is require

40 ERAP1 variants associated with reduced endopeptidase activity appear to be protective against A

41 Previously, we reported an endopeptidase activity based method (Endopep-MS) that de

42 Increased endopeptidase activity in these cells was shown to inter

43 II MCPs exhibit Ca(2+) dependence for their endopeptidase activity in vitro.

44 show that the eponymous asparagine-specific endopeptidase activity is electrostatically generated by

45 The endopeptidase activity is specific to hydrolysis of 4,3-

46 The toxicity is related to a poor zinc endopeptidase activity located in a 50-kDa domain known

47 Endopeptidase activity may be the main switch that gover

48 peptide substrates to measure the intrinsic endopeptidase activity of bead-captured BoNT.

49 that Bacillus subtilis cells require the DL-endopeptidase activity of CwlO or LytE for growth.

50 nique in that it can effectively distinguish endopeptidase activity of FAP from that of other related

51 We also detected the endopeptidase activity of orally administered BoNT/A1 co

52 tion with one another and that control of PG endopeptidase activity represents an important point of

53 s study, we report that NEP has the dominant endopeptidase activity toward Abeta in macrophages.

54 1 has a peptidoglycan D-isoglutamyl-L-lysine endopeptidase activity via a NlpC/P60 homology domain.

55 PBP4 DD-endopeptidase activity was also affected, with substitut

56 SagA secretion and NlpC/p60-endopeptidase activity was required for enhancing probio

57 ked peptidoglycan (the substrate for the 4,3-endopeptidase activity) increase.

58 was accompanied with great reduction of NEP endopeptidase activity, which might be due to the dimini

59 their peptidoglycan that suggest elevated DL-endopeptidase activity.

60 eptidase- (amino- or carboxy-), amidase-, or endopeptidase activity.

61 to be essential for AIP production and AgrB endopeptidase activity.

62 nd possesses both dd-carboxypeptidase and dd-endopeptidase activity.

63 d aminopeptidase activity but no carboxy- or endopeptidase activity.

64 s of inhibitors specific for the asparaginyl endopeptidases (AE) (legumains).

65 Asparaginyl endopeptidase (AEP or legumain) is a lysosomal cysteine

66 terminal acyclic TI, depends on asparaginyl endopeptidase (AEP) for maturation.

67 to determine the extent to which asparagine endopeptidase (AEP) influences human Ag and Ii processin

68 Here, we show that asparagine endopeptidase (AEP) is activated under acidic condition,

69 Asparagine endopeptidase (AEP) is an unusually specific endosomal a

70 cleavage after amino acid 368 by asparagine endopeptidase (AEP) is upregulated in Alzheimer's diseas

71 ctodomain and can be performed by asparagine endopeptidase (AEP) or cathepsin family members.

72 delta-secretase, also known as asparagine endopeptidase (AEP) or legumain, is a lysosomal cysteine

73 illing of bacteria by AMs through asparagine endopeptidase (AEP), a key endosomal cysteine protease.

74 Here we show that asparagine endopeptidase (AEP), a lysosomal cysteine proteinase, is

75 Here we show that asparagine endopeptidase (AEP), a pH-controlled cysteine proteinase

76 Asparagine endopeptidase (AEP), also called legumain, is highly exp

77 identified unique expression of asparaginyl endopeptidase (AEP), intercellular adhesion molecule 1 (

78 Delta-secretase, a lysosomal asparagine endopeptidase (AEP), simultaneously cleaves both APP and

79 Asparaginyl endopeptidase (AEP), which is overexpressed predominantl

80 milar structural fold with other asparaginyl endopeptidases (AEP).

81 Asparaginyl endopeptidases (AEPs) are cysteine proteases which break

82 In seeds, PawS1 is matured by asparaginyl endopeptidases (AEPs) into the cyclic peptide SFTI-1 (su

83 ides a rationale for the mechanism of BoNT/E endopeptidase against its intracellular substrate, SNAP-

84 precursor of AIP, and the integral membrane endopeptidase AgrB.

85 The peptidoglycan endopeptidase, AmpH, was identified as being important f

86 and analyzed, under the same conditions, the endopeptidase and carboxypeptidase-like activities of th

87 acid or pH 6.0 medium activated asparaginyl endopeptidase and consequently produced the cleavage of

88 bitors of dipeptidyl peptidase-IV and prolyl endopeptidase and could potentially be used as dietary i

89 over chemistry of Pgp3 reveals cell wall D,D-endopeptidase and D,D-carboxypeptidase activities.

90 ECEL1 encodes a neuronal endopeptidase and is expressed in the brain and peripher

91 llular matrix collagen breakdown with prolyl endopeptidase and leukotriene A4 hydrolase serving as th

92 The highly conserved Kinase, Endopeptidase and Other Proteins of small Size (KEOPS)/E

93 fsANP are preferentially degraded by neutral endopeptidase and serine peptidases, respectively.

94 ith significant homology to mammalian prolyl endopeptidase and the bacterial peptidase oligopeptidase

95 serotype D (GHRH-LHN/D, where HN/D indicates endopeptidase and translocation domain type D).

96 ty to Type VI secretion system peptidoglycan endopeptidases and recognition by the Drosophila innate

97 fluorescent probe in vitro using a panel of endopeptidases and specific inhibitor.

98 /P60 domain (gamma-d-glutamyl-l-diamino acid endopeptidase) and is expected to play an important role

99 orescent domains separate on cleavage by the endopeptidase, and emission from the directly excited GF

100 hat other thiorphan/phosphoramidon-sensitive endopeptidases are at work.

101 ting that yet other NEP-like Abeta-degrading endopeptidases are contributing to Abeta catabolism.

102 Asparaginyl endopeptidases are crucial in the final stage of the hea

103 These experiments revealed that endopeptidases are the major proteolytic activities secr

104 matrix metalloproteases 8 and -9 and prolyl endopeptidase, are also elevated in these samples.

105 ays, enzyme-linked immunosorbent assays, and endopeptidase assays and by mass spectrometry.

106 BoNT endopeptidase assays using short substrate homologues ha

107 diabetes, I2(PP2A) is cleaved by asparaginyl endopeptidase at Asn-175 into the N-terminal fragment (I

108 consisting of basic residues by well studied endopeptidases belonging to the subtilisin superfamily.

109 tability and high specificity for particular endopeptidases but have not been extensively studied for

110 AcPGP by more than 50% (P < 0.01) and prolyl endopeptidase by 46% (P = 0.02), without significant imp

111 KFL), a substrate of the endosomal/lysosomal endopeptidase cathepsin B, connected to oligo-(L)-lysine

112 encing analysis, we identified the lysosomal endopeptidase cathepsin Ba (ctsba) as the gene deficient

113 n (ChiW) and a putative l-alanyl-d-glutamate endopeptidase (ChiX), and subsequent biochemical analyse

114 Endopeptidase cleavage at Lys(91) generates a cleaved gl

115 Specific endopeptidases cleave chromogranin A into biologically a

116 ocate intracellularly, where the light-chain endopeptidase cleaves the SNARE complex proteins, subver

117 rived from Streptococcus pyogenes (IdeS), an endopeptidase, cleaves human IgG into F(ab')2 and Fc fra

118 in anaphase when separase, a giant cysteine endopeptidase, cleaves the Scc1/Rad21 subunit of cohesin

119 was reported that GCPII can also serve as an endopeptidase cleaving amyloid beta (Abeta) peptides and

120 weight protein 7), and MECL1 (multicatalytic endopeptidase complex subunit 1) subunit, affects TnI-di

121 polypeptide (LMP) 2 (beta1i), multicatalytic endopeptidase complex-like-1 (beta2i), and LMP7 (beta5i)

122 ent of the paralytic disease botulism, is an endopeptidase composed of a catalytic domain (or light c

123 that deficiency of the VWF-cleaving ADAMTS13 endopeptidase contributes to the development of VEGF inh

124 dual transglycosylases, transpeptidases, and endopeptidases could introduce new material into an exis

125 Further, we identified the metallo-endopeptidase CpaA, which has been shown previously to c

126 tilis encodes two functionally redundant D,L-endopeptidases (CwlO and LytE) that cleave peptide cross

127 cell wall elongation requires two redundant endopeptidases, CwlO and LytE.

128 hat resist intestinal proteases by exogenous endopeptidases, decrease of intestinal permeability by b

129 mimicked these events in situ by asparagine endopeptidase degradation of alpha-syn fibrils.

130 The purified endopeptidase degraded gonococcal peptidoglycan in vitro

131 olism is dependent on degradation by neutral endopeptidase, dipeptidyl peptidase IV, and aminopeptida

132 Although endopeptidase, dipeptidyl peptidase, tripeptidyl peptida

133 in lytic activity conferred on the LambdaSa2 endopeptidase domain by either LysK or lysostaphin SH3b

134 ion within the zinc coordination site of the endopeptidase domain completely abolished SXN101742 inhi

135 d GH-releasing hormone (GHRH) domain and the endopeptidase domain of botulinum toxin serotype D (GHRH

136 ytic activity conferred on the streptococcal endopeptidase domain, and surprisingly these same fusion

137 erminal extension, cleaved off by a specific endopeptidase during maturation.

138 es inactivation domain and Ras/Rap1-specific endopeptidase each exert greater effects on virulence th

139 t proteolytic complex, is a highly conserved endopeptidase encoded by CLPP and forms an element of th

140 We showed that fibulin-4 binds procollagen C-endopeptidase enhancer 1 (Pcolce), which enhances proteo

141 ed in fibroblasts--collagen I, procollagen C endopeptidase enhancer 1, secreted protein acidic and ri

142 ignificant correlation between procollagen C-endopeptidase enhancer protein 2 (PCPE2) single nucleoti

143 ted by PG cleavage enzymes, for example, the endopeptidases (EPs).

144 The PHEX gene encodes a zinc endopeptidase expressed in osteoblasts and contributes t

145 oproteinases (MMPs) are a family of secreted endopeptidases expressed by neurons and glia.

146 sA is a structurally distinct member of this endopeptidase family, consistent with its activity again

147 Asparaginyl endopeptidase from Alzheimer disease brain could cleave

148 Here, we evaluate the usage of a prolyl endopeptidase from Aspergillus niger (An-PEP) for HDX-MS

149 cipitation was applied to fractionate glycyl endopeptidase from the papaya latex of Red Lady and Khac

150 To counteract endopeptidases from the host or microbial competitors, T

151 inhibitor composed of the RAS-RAP1-specific endopeptidase fused to the protein delivery machinery of

152 Glutamyl endopeptidase (GE) from Alcalase 2.4 L was purified usin

153 canase gene atlA but carried a peptidoglycan endopeptidase gene in place of atlA.

154 that treatment with GLP-1(28-36), a neutral endopeptidase-generated (NEP-generated) metabolite of GL

155 e binding pocket conserved in active metallo-endopeptidases has been adapted to control PG hydrolysis

156 MMP-14, a membrane-bound zinc endopeptidase, has been proposed to play a central role

157 A serine endopeptidase, hereby-named Destructin-1, was subsequent

158 atrix protein 1), Phex (phosphate-regulating endopeptidase homolog), and Bsp (bone sialoprotein).

159 mg/dL), confirmed PHEX (phosphate-regulating endopeptidase homolog, X-linked) mutation or variant of

160 for helical shape: three LytM peptidoglycan endopeptidase homologs (csd1-3) and a ccmA homolog.

161 enesis of Alzheimer disease, and asparaginyl endopeptidase-I2(PP2A)-protein phosphatase 2A-Tau hyperp

162 e additional deletion of lytE, encoding a DL-endopeptidase important for cell elongation, in the ugtP

163 Here, we identify DipM, a putative LytM endopeptidase in Caulobacter crescentus, and show that i

164 cell shape and suggest that the role of this endopeptidase in forming coccoid morphology may be criti

165 eptidase inhibitor, which is cleaved by host endopeptidases in an accessible bait region.

166 In contrast, the major endopeptidases in the digestive fluid of the Venus flytr

167 trategies were tested: inhibition of neutral endopeptidase, inhibition of aldose reductase plus lipoi

168 ity when given in combination with a neutral endopeptidase inhibitor (enhances endogenous natriuretic

169 tulinum neurotoxin A light chain (BoNT/A LC) endopeptidase inhibitor by screening the National Cancer

170 Through single coinjection of the neutral endopeptidase inhibitor phosphoramidon (PA), we were abl

171 dozen genes, including activation of serine endopeptidase inhibitor SERPINE1 and inactivation of TP5

172 ut microbiome encode a relative of the human endopeptidase inhibitor, alpha2-macroglobulin (alpha2M).

173 of plasma proteins including serine protease/endopeptidase inhibitors, coagulation factors, complemen

174 f the largest and most conserved families of endopeptidases involved in diverse cellular activities,

175 occus aureus lysostaphin and LytM, and to DD-endopeptidases involved in entry of bacteriophage to hos

176 ix metalloproteases (MMPs) are Zn-containing endopeptidases involved in the degradation of extracellu

177 show that the level of activated asparaginyl endopeptidase is significantly increased, and this enzym

178 AP cross-links whose cleavage by specialized endopeptidases is crucial for expansion of PG predominat

179 that the cleavage of cross-links by the new endopeptidases is needed for surface growth of the saccu

180 Limited proteolysis, accomplished by endopeptidases, is a ubiquitous phenomenon underlying th

181 consists of five proteins, Kinase-Associated Endopeptidase (Kae1), a highly conserved protein present

182 e inactive pro-forms of KDEL-tailed cysteine endopeptidases (KDEL-CysEP) associated with programmed c

183 The BoNT/A LC endopeptidase kinetics at the optimally active temperatu

184 in this study as a SNAP-25 homologue for the endopeptidase kinetics study of BoNT/A LC.

185 as incubated with neprilysin (300 ng/ml), an endopeptidase known to hydrolyze Abeta1-40 and the expec

186 Nep1.SIGNIFICANCE STATEMENT Neprilysins are endopeptidases known to degrade a number of small peptid

187 Neprilysins are endopeptidases known to degrade a number of small peptid

188 n the active site of the acid-active gliadin endopeptidase KumaMax.

189 tivity of the redox-sensitive ATG4B cysteine endopeptidase, leading to enhanced LC3B delipidation and

190 shown to be potent inhibitors of asparaginyl endopeptidases (legumains) from the bloodfluke, Schistos

191 Prolyl endopeptidase-like (PREPL) is a newly described member o

192 ase and Other Proteins of small Size (KEOPS)/Endopeptidase-like and Kinase associated to transcribed

193 to the peptidoglycan-targeting glycylglycine endopeptidase lysostaphin, compared to the wild type.

194 um toxin was detected in patient serum using Endopeptidase-mass-spectrometry assay, although all conv

195 s developed for the quantitation of the zinc endopeptidase matrix metalloproteinase 9 (MMP-9) from mo

196 Our previous results showed that an endopeptidase, matrix metalloproteinase-3 (MMP3), was in

197 tem on a neighboring strand, suggesting that endopeptidases may be required for the release of many p

198 lic peptides, appears to involve asparaginyl endopeptidase-mediated processing from larger precursor

199 or the suppression process, as was a related endopeptidase, MepA.

200 lacking mepK and another d-Ala-mDAP-specific endopeptidase (mepS) were synthetic sick, and the defect

201 tter the relationship between ICAM-5 and the endopeptidase metalloproteinase-9 (MMP-9), which mediate

202 dipeptidyl peptidase-IV (DPP-IV) and neutral endopeptidase (NEP) 24.11 severely compromises its effec

203 establish the effect of oleacein on neutral endopeptidase (NEP) activity and other functions of huma

204 a half-life due to its resistance to neutral-endopeptidase (NEP) digestion.

205 d modeling approaches, we identified neutral endopeptidase (NEP) that is up-regulated in human AAA ti

206 The endopeptidase neprilysin (NEP) is a major amyloid-beta (

207 The endopeptidase neprilysin has been successfully used to r

208 d to decreased levels of the metallomembrane endopeptidase neprilysin, normal levels were maintained

209 through the expression and execution of two endopeptidases, neprilysin (NEP) and insulin-degrading e

210 We demonstrated recently that pneumococcal endopeptidase O (PepO) is a ubiquitously expressed, mult

211 entified a novel 72-kDa pneumococcal protein endopeptidase O (PepO), as a plasminogen- and fibronecti

212 recombinant Oldenlandia affinis asparaginyl endopeptidase, OaAEP1, is promiscuous for incoming nucle

213 to different enzymatic treatments using two endopeptidases of different selectivity and one exopepti

214 in uniquely blocked many serine and cysteine endopeptidases of disparate architecture and substrate s

215 ss a single target bond and inhibit selected endopeptidases of particular specificity and class.

216 -regulating gene, which is homologous to the endopeptidases of the X-chromosome (PHEX).

217 ely 10(5) M(-1)s(-1)) variant of the E. coli endopeptidase OmpT that selectively hydrolyzes peptides

218 phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) and by dentin

219 phosphate-regulating gene with homologies to endopeptidases on the X chromosome (Phex) cause X-linked

220 phosphate-regulating gene with homologies to endopeptidases on the X-chromosome (PHEX).

221 ks angiotensin converting enzyme and neutral endopeptidase, on these endpoints.

222 cute lymphoblastic leukemia antigen, neutral endopeptidase, or enkephalinase, can be used as a marker

223 y ex vivo treatment with O-sialoglycoprotein endopeptidase (OSGE) can reverse many aspects of the age

224 s of ACE, chymase and NEP, ACE2, PEP (prolyl-endopeptidase), PCP (prolyl-carboxypeptidase) in kidney

225 Prolyl endopeptidase (PEP) cleaves neuropeptides and is a drug

226 ivity of a number of enzymes, such as prolyl endopeptidase (PEP, EC 3.4.21.26), has been linked to th

227 We find that the endopeptidase PepO suppresses the ComRS feedback loop, m

228 s degradation is mediated by the cytoplasmic endopeptidase PepO, which is the first identified enzyma

229 Inactivating mutations of the endopeptidase PHEX or the SIBLING protein DMP1 result in

230 associated mutations in phosphate-regulating endopeptidase (PHEX) result in elevated serum FGF23, dec

231 y ADAM (a disintegrin and metalloproteinase) endopeptidases plays a key role in a wide variety of bio

232 Separase, an endopeptidase, plays a pivotal role in the separation of

233 We find that P. aeruginosa LasA endopeptidase potentiates lysis of S. aureus by vancomyc

234 were removed from partially purified glycyl endopeptidase (PPGE).

235 that of other related enzymes such as prolyl endopeptidase (PREP) and was validated using Fap-deficie

236 Prolyl endopeptidase (PREP) has been implicated in neuronal fun

237 Prolyl endopeptidase (Prep) is a member of the prolyl peptidase

238 A predicted target of miR-324-3p is prolyl endopeptidase (Prep), a serine peptidase involved in the

239 e distinct from the well-described CaaX-type endopeptidases RAS Converting Enzyme1 (RCE1) and zinc me

240 believed to catalyze DD-carboxypeptidase and endopeptidase reactions in vivo.

241 ondin motifs (ADAMTS) constitute a family of endopeptidases related to matrix metalloproteinases.

242 ogical significance of MLL1 cleavage by this endopeptidase remains unclear.

243 erefore, we hypothesize that SCO4 is a novel endopeptidase required for critical protein modification

244 cules with minimum interacting motifs showed endopeptidase resistance and better inhibitory activitie

245 s resemble lysozyme-like enzymes and metallo-endopeptidases, respectively.

246 on in regulating OCN and the identity of the endopeptidase responsible for pro-OCN cleavage in osteob

247 te that this new family of Ras/Rap1-specific endopeptidases (RRSPs) has potential to inactivate both

248 ial for matrix metalloprotease-9 (MMP-9), an endopeptidase secreted in response to neuronal activity,

249 Endopeptidases sensitive to inhibition by thiorphan and

250 in diameter and contain DNA, adhesin P5, IgA endopeptidase, serine protease, and heme utilization pro

251 escentus, with a specific focus on LytM-like endopeptidases, soluble lytic transglycosylases and amid

252 ococcus maripaludis homologue of Rce1, whose endopeptidase specificity for farnesylated peptides mimi

253 oligopeptidase (PREP), with which it shares endopeptidase specificity.

254 fication in Escherichia coli of three new DD-endopeptidases (Spr, YdhO and YebA) which are collective

255 For example, cysteine protease (SspB), endopeptidase (SspA), staphopain (ScpA), and aureolysin

256 peptidase related to autolytic glycylglycine endopeptidases such as Staphylococcus aureus lysostaphin

257 The threonine endopeptidase Taspase1 has a critical role in cancer cel

258 We show that AlbD is a novel type of endopeptidase that catalyzes the cleavage of albicidin a

259 romatography, and gp13 was found to be a d,d-endopeptidase that cleaved the peptide cross-link.

260 from Vibrio vulnificus to be a site-specific endopeptidase that cleaves within the Switch 1 region of

261 Neprilysin is an endopeptidase that degrades vasoactive peptides, includi

262 They identify a novel endopeptidase that is necessary to generate the helical

263 ur results clearly identify AlbD as a unique endopeptidase that is the first member of a new subfamil

264 rix metalloproteinase (MMP)-9 expression, an endopeptidase that participates in diverse pathologic pr

265 hemical studies show that SagA is a NlpC/p60-endopeptidase that preferentially hydrolyzes crosslinked

266 that matrix metalloproteinase-9 (MMP-9), an endopeptidase that regulates the pericellular environmen

267 involved in this pathway is AgrB, a membrane endopeptidase that removes the AgrD carboxy-tail.

268 Separase is an endopeptidase that separates sister chromatids by cleavi

269 Botulinum neurotoxins (BoNTs) are zinc endopeptidases that block release of the neurotransmitte

270 d/or biochemically characterized are metallo-endopeptidases that cleave cross-links in the peptidogly

271 f Haemophilus influenzae are highly specific endopeptidases that cleave the hinge region of human IgA

272 trix metalloproteinases (MMPs) are inducible endopeptidases that degrade extracellular matrix (ECM) p

273 etome of P. destructans, and identify serine endopeptidases that have the clear potential to facilita

274 t A (HtrA) proteases are ATP-independent Ser endopeptidases that perform key aspects of protein quali

275 proteinases (MMPs) comprise a family of zinc endopeptidases that play major roles in the physiology a

276 Matrix metalloproteinases (MMPs) are zinc endopeptidases that play roles in numerous pathophysiolo

277 Matrix metalloproteases (MMPs) are endopeptidases that regulate diverse biological processe

278 ive to proteases (cathepsin B and asparagine endopeptidase) that are over-expressed by resistant leuk

279 a substrate for proteolytic cleavage by the endopeptidase threonine aspartase 1 (taspase1); however,

280 red for kidney membranes or purified neutral endopeptidase to abolish ANP-dependent activation of NPR

281 ces before or after the scissile bond showed endopeptidase to be superior to dipeptidase activity for

282 ach can be successfully used for any type of endopeptidase to deliver high activity and selectivity i

283 etion pathway of Serratia marcescens uses an endopeptidase to facilitate secretion, whereas the secre

284 in/SUMO-specific proteases (SENPs) act as an endopeptidase to process the pre-SUMO or as an isopeptid

285 n conjunction with other elongation-specific endopeptidases to make space for efficient incorporation

286 elongation requires crosslink cleavage by PG endopeptidases to make space for the incorporation of ne

287 led human IgG (intravenous Ig) in vitro upon endopeptidase treatment.

288 d peptidoglycan, whereas LytM, a pentaglycyl-endopeptidase, triggers polypeptide release from the bac

289 describe the first crystal structures of the endopeptidase-type gammaGH (zgammaGH) from zebrafish and

290 The isolation of endopeptidase variants that can discriminate between sub

291 Protamex, an endopeptidase was used to digest oat bran protein isolat

292 ld-type neutrophils with O-sialoglycoprotein endopeptidase was used to reduce the PSGL-1 density to t

293 vels of the enzyme that degrades SP, neutral endopeptidase, were increased.

294 roadly speaking, SENP1 is the most efficient endopeptidase, whereas SENP2 and -5-7 have substantially

295 Ps belong to the zinc- and calcium-dependent endopeptidases which are involved in the proteolytic deg

296 d metalloproteinases are members of the zinc endopeptidases, which cleave components of the extracell

297 try involves the predator's peptidoglycan DD-endopeptidases, which decrosslink cell walls and prevent

298 Calpain is a family of calcium-dependent endopeptidases, which plays an important role in ECM rem

299 Glycyl endopeptidase with high purification fold (PF) and yield

300 ion of Tau, and the knockdown of asparaginyl endopeptidase with siRNA abolished this pathway in SH-SY

301 d MepK), as an mDAP-mDAP cross-link cleaving endopeptidase working in conjunction with other elongati