ライフサイエンスコーパス: endophthalmitis

1 no ocular serious AEs (SAEs) and no cases of endophthalmitis.

2 dent risk factor for recurrent postinjection endophthalmitis.

3 follow-up in eyes with filtering-associated endophthalmitis.

4 ciated with worse outcomes in post-procedure endophthalmitis.

5 ostoperative among patients with and without endophthalmitis.

6 associated with improved visual outcomes in endophthalmitis.

7 ic allergies who were treated for infectious endophthalmitis.

8 was 1.55% in comparison with infants without endophthalmitis.

9 on the basis of diagnostic codes for GDI and endophthalmitis.

10 demonstrated that SAP alone does not prevent endophthalmitis.

11 l factors in the prevention of postoperative endophthalmitis.

12 r the cataract surgery to obtain the rate of endophthalmitis.

13 of 25 patients with culture-proven Nocardia endophthalmitis.

14 nts (68 eyes) were diagnosed with endogenous endophthalmitis.

15 ces of anti-VEGF administration and cases of endophthalmitis.

16 fragments, retinal detachment, and suspected endophthalmitis.

17 ve better outcomes in treatment of Bipolaris endophthalmitis.

18 intravitreal injection and was found to have endophthalmitis.

19 hthalmitis, and change in VA 12 months after endophthalmitis.

20 risk for eye infections including bacterial endophthalmitis.

21 yes) (P = 0.6), and no patient had bilateral endophthalmitis.

22 fragments, retinal detachment, and suspected endophthalmitis.

23 causes of post-operative and post-traumatic endophthalmitis.

24 s complications, such as lens subluxation or endophthalmitis.

25 There were no cases of fungal endophthalmitis.

26 topics in the prophylaxis and management of endophthalmitis.

27 ical management and outcomes of each case of endophthalmitis.

28 tic rabbit model of Streptococcus pneumoniae endophthalmitis.

29 ic choice for the treatment of Gram-positive endophthalmitis.

30 inical outcomes associated with each case of endophthalmitis.

31 be necessary in all cases of DEX-associated endophthalmitis.

32 hen and now) in prevention and management of endophthalmitis.

33 l complication remains a key risk factor for endophthalmitis.

34 ressure also was performed for patients with endophthalmitis.

35 lopment of neonatal and infantile endogenous endophthalmitis.

36 causative organisms were not associated with endophthalmitis.

37 hs, and 1 eye became phthisical 1 year after endophthalmitis.

38 innate immune responses in S aureus-induced endophthalmitis.

39 ays an important role in prognosis following endophthalmitis.

40 ture methods, in patients with postoperative endophthalmitis.

41 ases of IOI, retinal arterial occlusion, and endophthalmitis.

42 20/40 (median, 20/30) among patients without endophthalmitis.

43 treated for at least 2 separate episodes of endophthalmitis.

44 ial examination and at 6 months in eyes with endophthalmitis.

45 strengthen the therapeutic strategy of acute endophthalmitis.

46 ltrasound were more likely to be treated for endophthalmitis.

47 period of interest, resulting in 58 cases of endophthalmitis (0.038% [1:2659]).

48 surgery, 3629 of which developed acute-onset endophthalmitis (0.04%; 95% confidence interval, 0.04%-0

49 The most common serious ocular TEAE was endophthalmitis (0.5% [n = 3]).

50 6 cases (83%) had culture-proven infectious endophthalmitis (2 Candida glabrata, 2 coagulase-negativ

51 avitreal injection (2/19, 10.5%), endogenous endophthalmitis (2/19, 10.5%), post-pars plana vitrectom

52 elt (5 eyes), infectious keratitis (3 eyes), endophthalmitis (3 eyes), GDD erosion (2 eyes), and reti

53 RD (11%), intraocular foreign body (5%), and endophthalmitis (3%).

54 Of 133 eyes with endophthalmitis, 33 (25%) received oral steroids.

55 Of the 133 cases of presumed infectious endophthalmitis, 74% were unrelated to cataract surgery.

56 After initial treatment of endophthalmitis, a change in clinical management after v

57 derwent subsequent vitrectomy for persistent endophthalmitis after a mean of 37 days.

58 The incidence of endophthalmitis after anti-VEGF injections is low.

59 rdless of the presenting vision in eyes with endophthalmitis after cataract surgery and intravitreal

60 sence of disc or macular view and absence of endophthalmitis after cataract surgery were associated w

61 of 111 eyes of 111 patients were treated for endophthalmitis after cataract surgery, of which 57 (51%

62 ty (VA) outcomes associated with acute-onset endophthalmitis after clear corneal cataract surgery ove

63 Two patients had culture-proven bacterial endophthalmitis after DEX monoinjections (0.06% of injec

64 StudyPopulation: Individuals developing endophthalmitis after DSEK at the Duke Eye Center from J

65 The rate of endophthalmitis after EK (4 of 2292; 0.2%) was significa

66 and graft prognosis compared with those with endophthalmitis after EK.

67 jelly or Tetravisc may increase the risk of endophthalmitis after injection.

68 not statistically significant predictors of endophthalmitis after injection.

69 0.03) use were independent risk factors for endophthalmitis after injection.

70 Patients who developed endophthalmitis after intravitreal injection of afliberc

71 erm outcomes of infectious and noninfectious endophthalmitis after intravitreal injections (IVTs) of

72 e incidences of infectious and noninfectious endophthalmitis after IVT were low, and the risk did not

73 Eyes with endophthalmitis after PK had poorer visual acuity outcom

74 In addition, the odds of developing endophthalmitis after PK or EK performed in conjunction

75 sed to compare rates of filtering-associated endophthalmitis after trabeculectomy and tube-shunt impl

76 icant differences were found between rate of endophthalmitis after trabeculectomy or tube-shunt impla

77 3593 injections of DEX, 4 patients developed endophthalmitis; all 4 patients were white, female, and

78 Two cases of culture-positive endophthalmitis and 1 case of culture-negative endophtha

79 Visual acuity (VA) at presentation with endophthalmitis and at 6 months were assessed for each p

80 90-day cumulative incidence of postoperative endophthalmitis and choroidal hemorrhage following EK wa

81 cidence of neonatal and infantile endogenous endophthalmitis and comorbidities as well as risk factor

82 e was a necessary risk factor for late-onset endophthalmitis and required surgical removal or repair.

83 Cumulative rate of endophthalmitis and survival curves were measured using

84 s old that developed presumed post-procedure endophthalmitis and were treated at our center from 2009

85 Incidence and cumulative rate of endophthalmitis, and change in VA 12 months after endoph

86 red in 19 of 111 eyes (17%) after developing endophthalmitis, and culture-positive eyes developed a s

87 ted cases of intraocular inflammation (IOI), endophthalmitis, and retinal arterial occlusion in the p

88 There were no cases of endophthalmitis, and the total incidence of Anti-Platele

89 Coryneform bacteria are a rare cause of endophthalmitis, and this is the first reported case of

90 The mainstay empiric treatments of bacterial endophthalmitis are intravitreal vancomycin and ceftazid

91 role of systemic steroids in post-procedural endophthalmitis as the role of intravitreal steroids in

92 owledge, the optimal management of eyes with endophthalmitis associated with DEX has not been establi

93 Cases of endophthalmitis associated with DEX were also identified

94 Adults diagnosed with endophthalmitis at the Duke Eye Center from January 1, 2

95 ive chart review of patients with endogenous endophthalmitis at the University of Florida from June 2

96 ptibility of Gram-positive and Gram-negative endophthalmitis bacterial isolates to vancomycin, amikac

97 query was performed to identify all cases of endophthalmitis based on diagnosis and procedure billing

98 shion to determine independent predictors of endophthalmitis based on injection protocol.

99 predictors for the development of endogenous endophthalmitis based on multivariate logistic regressio

100 Recovery of vision to within 2 lines of pre-endophthalmitis baseline was achieved in 53% of patients

101 alter the intravitreal antibiotic choice for endophthalmitis because of concern for allergic reaction

102 based reports regarding bacterial endogenous endophthalmitis (BEE) are scarce in the literature.

103 ole when considering ISBCS, with the risk of endophthalmitis being most feared.

104 Despite endophthalmitis being the most feared complication, anti

105 w compared to the other studies with rate of endophthalmitis between 0.019-0.09%.

106 days; n = 1650) hospitalized for endogenous endophthalmitis between 2003 and 2014 and infants (age r

107 dentify neonates hospitalized for endogenous endophthalmitis between 2003 and 2014 and infants hospit

108 ifference in acute (<=6 weeks) postoperative endophthalmitis between groups 1 and 2.

109 review of patients diagnosed with endogenous endophthalmitis between September 1, 2006, and November

110 tients were identified with the diagnosis of endophthalmitis by International Classification of Disea

111 dary to an endogenous source in 23.5% of all endophthalmitis cases observed.

112 ound to be duplicated, so that the number of endophthalmitis cases was unclear as was the associated

113 Overall, 45% of endophthalmitis cases were culture proven.

114 Endophthalmitis cases were determined from billing recor

115 Changes in management for culture-negative endophthalmitis cases were performed based on declining

116 trospectively reviewed for all patients with endophthalmitis caused by Corynebacterium species from J

117 reatment, and visual acuity (VA) outcomes of endophthalmitis caused by Corynebacterium species.

118 Patients with endophthalmitis caused by Corynebacterium species.

119 itis, and this is the first reported case of endophthalmitis caused by the corynebacterium species Tu

120 of major postoperative complications (i.e., endophthalmitis, choroidal hemorrhage, infectious kerati

121 ssociated with a 3.68-fold increased risk of endophthalmitis (CI, 1.89-7.20).

122 l records were then reviewed to evaluate the endophthalmitis clinical features and treatment outcomes

123 Two-thirds of the patients in this endophthalmitis cohort experienced a visual outcome of >

124 did not influence the risk of postinjection endophthalmitis compared to a no-talking policy.

125 oes not seem to worsen long-term outcomes of endophthalmitis compared to those patients that did not

126 evacizumab group included 1 participant with endophthalmitis (culture negative), 9 with IOP more than

127 Of the 24 recorded episodes of endophthalmitis, culture results were positive in 41.6%,

128 The incidence of endogenous endophthalmitis declined in both the neonatal and infant

129 A subgroup of 25 cases (19.8%) developed endophthalmitis despite receiving a SAP by cefuroxime at

130 Three other cases of endophthalmitis developed after coinjection with bevaciz

131 Noninfectious endophthalmitis developed in 11 of 88 150 injections (1/

132 Infectious endophthalmitis developed in 18 of 88 150 injections (1/

133 Fungal endophthalmitis developed in 92% (23/25) of eyes.

134 ology clinic visit, and filtering-associated endophthalmitis diagnoses were obtained and used to perf

135 niae and Coagulase negative Staphylococci in endophthalmitis diagnoses.

136 However, the "risk" of infectious endophthalmitis did not increase with each successive in

137 Endogenous Candida endophthalmitis (ECE) has been established with microsco

138 is a known risk factor for endogenous fungal endophthalmitis (EFE), a severe intraocular infection ca

139 Endogenous K. pneumoniae endophthalmitis (EKE) has a higher incidence among East

140 in clinical management for culture-negative endophthalmitis eyes was based on worsening clinical exa

141 Cancer patients have a similar risk of endophthalmitis following cataract surgery as the noncan

142 Development of endophthalmitis following DEX and the clinical managemen

143 However, given the rarity of endophthalmitis following DEX and the heterogeneity amon

144 The rate of endophthalmitis following dexamethasone intravitreal imp

145 measure was incidence of presumed infectious endophthalmitis following PK or EK.

146 The management of endophthalmitis from different etiologies, including end

147 Following endophthalmitis from intravitreal injection of anti-VEGF

148 with persistently vitreous culture-positive endophthalmitis had poor visual outcomes.

149 plication, which included sterile vitreitis, endophthalmitis, hypotony maculopathy, suprachoroidal he

150 povidone-iodine; both participants developed endophthalmitis in 1 eye.

151 We confirmed 1 case of postoperative endophthalmitis in 10 494 ISBCS eyes (1.0 per 10 000 eye

152 ophthalmitis was within +/-2 lines of before endophthalmitis in 53% and 75% of eyes, respectively; a

153 tachment in 18.8% (9 of 48 eyes), infectious endophthalmitis in 6.3% (3 of 48 eyes), and choroidal de

154 To report the incidence of culture-proven endophthalmitis in a single vitreoretinal practice over

155 cians should suspect chronic, post-operative endophthalmitis in any case of recurrent, low-grade intr

156 The incidence of endophthalmitis in our patients with microbial keratitis

157 rly 4-fold lower rate of early postoperative endophthalmitis in patients undergoing trabeculectomy or

158 the 12 patients (66%) experienced recurrent endophthalmitis in the same eye, and 4 of the 12 patient

159 ated the management strategies of infectious endophthalmitis in the setting of self-reported systemic

160 experience more than 1 episode of infectious endophthalmitis in their lifetime.

161 Endophthalmitis incidence was highest among patients age

162 e 19 study patients, the clinical setting of endophthalmitis included post-cataract surgery (7/19, 36

163 ntial for evaluating rare conditions such as endophthalmitis, including developing benchmarks, longer

164 Infectious endophthalmitis is a devastating, yet rare, complication

165 Endophthalmitis is a rare but potentially devastating co

166 These data suggest that endophthalmitis is a rare event following injection of D

167 Despite advances over the past 100 years, endophthalmitis is an important sight-threatening compli

168 Endogenous endophthalmitis is an infection of the eye secondary to

169 Endogenous endophthalmitis is associated with Klebsiella pneumoniae

170 It is unclear whether the severity of endophthalmitis is greater in these patients due to conf

171 Risk of filtering-associated endophthalmitis is persistent and relatively constant fo

172 Recurrent endophthalmitis is rare and seen most commonly after int

173 The visual outcome in Nocardia endophthalmitis is very guarded when presenting vision i

174 , Candida glabrata, and Candida parapsilosis endophthalmitis isolates were each inoculated into optis

175 retained vision within 10 letters of the pre-endophthalmitis level.

176 studies leading to changes in strategies for endophthalmitis management over the last 100 years.

177 ized trial of systemic corticosteroid use in endophthalmitis may be warranted.

178 As in this case, post-intravitreal injection endophthalmitis may have a bacterial etiology even with

179 DSEK-related endophthalmitis may lead to severe vision loss, even wit

180 omplications included hyphema (n = 3; 6.8%), endophthalmitis (n = 1; 2.3%), wound leak (n = 1; 2.3%),

181 rrhage (n = 10), vitreous opacities (n = 8), endophthalmitis (n = 4), sub-silicone oil retinal detach

182 ens (n = 10), submacular hemorrhage (n = 7), endophthalmitis (n = 6), and retained lens material (n =

183 Endophthalmitis occurred 4 times more often after combin

184 ccurred during the study period; 12 cases of endophthalmitis occurred after PK and 4 cases occurred a

185 Sixteen cases of endophthalmitis occurred during the study period; 12 cas

186 Acute-onset endophthalmitis occurred in 0.04% of 8 542 838 cataract

187 Acute postoperative endophthalmitis occurred in 1 case (0.26%).

188 However, no cases of oral flora-associated endophthalmitis occurred in the Face Mask group.

189 tered, 168 out of 453,460 (0.0371%) cases of endophthalmitis occurred in the No Talking group, and 9

190 dophthalmitis and 1 case of culture-negative endophthalmitis occurred in the pegcetacoplan monthly gr

191 s between groups (P = 0.99), and no cases of endophthalmitis occurred.

192 Eleven cases of endophthalmitis occurred; 4 occurred between 2012 and 20

193 Cases of acute-onset postoperative endophthalmitis occurring within 30 days after cataract

194 between 2006 and 2015 with culture-positive endophthalmitis occurring within 6 weeks of clear cornea

195 were identified and reviewed for etiology of endophthalmitis, ocular history, interventions, visual o

196 oid use was associated with culture-positive endophthalmitis (odds ratio [OR] 2.7; 95% confidence int

197 umulative incidence for filtering-associated endophthalmitis of 1.32%.

198 One patient developed endophthalmitis on 2 separate occasions.

199 No patients demonstrated endophthalmitis or metastatic disease or died during the

200 There were no cases of endophthalmitis or retinal detachment.

201 e in the rates of KPro extrusion (P = 0.41), endophthalmitis or vitritis (P = 0.15), retinal detachme

202 show VA improvement of 3 lines or more after endophthalmitis (OR, 2.8; 95% CI, 1.1-6.7) and to exhibi

203 implant migration into the anterior chamber, endophthalmitis, or retinal detachment.

204 a mouse model of Staphylococcus (S.) aureus endophthalmitis, our study demonstrates the induction of

205 ollow-up was significantly higher in post-PK endophthalmitis (P = .02).

206 Visual acuity before endophthalmitis, pain, and patient-reported blurred visi

207 However, 4% of endophthalmitis patients still achieved 20/20 or better

208 Endophthalmitis patients that were culture positive for

209 howed positive results in 66.7% and 26.7% of endophthalmitis patients, respectively.

210 sual acuity was 20/100 (median, 20/50) among endophthalmitis patients, versus a mean of approximately

211 the routine patient with suspected bacterial endophthalmitis, PCN allergy may not be an absolute cont

212 The cumulative rate of noninfectious endophthalmitis per patient was 0.087% and 0.228% after

213 Comorbidities prevalent in the endophthalmitis population included prematurity, respira

214 with previous ocular surgery, postoperative endophthalmitis, postoperative retinal detachment, reope

215 All cases of presumed injection-related endophthalmitis presenting to the Massachusetts Eye and

216 w evidence demonstrating lack of efficacy in endophthalmitis prevention as well as their potential ha

217 hese reported cases of Bipolaris hawaiiensis endophthalmitis provide important messages for clinician

218 There was no difference in endophthalmitis rate among the anti-VEGF agents (bevaciz

219 ed cases, it remains unclear whether the DEX endophthalmitis rate approximates that of intravitreous

220 To compare the postoperative endophthalmitis rate before and after initiation of intr

221 moxifloxacin prophylaxis reduced the overall endophthalmitis rate by 3.5-fold (3-fold for M-SICS and

222 Without IC moxifloxacin, PCR increased the endophthalmitis rate nearly 7-fold to 0.48% (20/4186); I

223 For the 414 657 M-SICS eyes, the endophthalmitis rate was 0.07% (135/192 149) without IC

224 The group 3 endophthalmitis rate was 0.07% (29 eyes), which was also

225 or the 194 252 phacoemulsification eyes, the endophthalmitis rate was 0.07% (75/104 894) without IC m

226 0.48% (20/4186); IC moxifloxacin reduced the endophthalmitis rate with PCR to 0.21% (9/4293) (P = 0.0

227 , and there was a significant decline in the endophthalmitis rate, from 0.07% (214/302 815) to 0.02%

228 The postoperative endophthalmitis rates before and after initiation of IC

229 Endophthalmitis rates before and after moxifloxaxin were

230 Importance: This report provides updated endophthalmitis rates for eyes receiving intravitreous i

231 ameral moxifloxacin, and acute postoperative endophthalmitis rates were compared.

232 After endophthalmitis related to cataract surgery, vitreous cu

233 avitreal steroids in treatment algorithms of endophthalmitis remain controversial.

234 he overall prognosis of filtering-associated endophthalmitis remains poor; however, good visual and a

235 The endophthalmitis responded well to treatment with intravi

236 s and two thirds of cases with noninfectious endophthalmitis retained vision within 10 letters of the

237 potentially serious side effects, including endophthalmitis, retinal and vitreous hemorrhage, and re

238 major postoperative complications including endophthalmitis, retinal detachment, and choroidal hemor

239 o assess the role of face mask use to reduce endophthalmitis risk, particularly attributable to oral

240 ination points might instead be explored for endophthalmitis risk.

241 Of 237 analyzed eyes, acute endophthalmitis secondary to cataract surgery or seconda

242 Patients with acute or delayed-onset endophthalmitis should benefit from microbiological iden

243 of 16 cases (43.8%) of filtering-associated endophthalmitis showed positive culture results from eit

244 Laboratory records of bacteria isolated from endophthalmitis specimens collected from January 1(st) 1

245 complication rates-return to operating room, endophthalmitis, suprachoroidal hemorrhage, retinal deta

246 acuity outcomes were poorer after PK-related endophthalmitis than EK-associated cases (P = .01).

247 owed after being treated for post-procedural endophthalmitis that either received systemic steroids o

248 Historically, 3 endophthalmitis time-periods have existed and include th

249 o susceptibilities of bacteria cultured from endophthalmitis to vancomycin (VAN), amikacin (AMK), and

250 Diagnosis of endophthalmitis upon hospital admission was associated w

251 Mean pre-endophthalmitis visual acuity (VA) was 20/64; mean VA at

252 MainOutcomeMeasures: Rate of endophthalmitis, visual acuity, and microbial spectrum.

253 s without antibiotic prophylaxis the rate of endophthalmitis was 0.0019% which is very low compared t

254 mortality rate for patients identified with endophthalmitis was 1.55% in comparison with infants wit

255 decline in incidence of neonatal endogenous endophthalmitis was 4% from 2003 through 2014.

256 from surgical procedure to presentation with endophthalmitis was 6.8 months (range: 1 day to 28 month

257 e mean time between surgery and diagnosis of endophthalmitis was 8 days (median 6 days).

258 Endophthalmitis was associated with 50% or more vitreous

259 Each successive episode of endophthalmitis was associated with a worse final visual

260 Visual acuity before endophthalmitis was associated with VA at 6 months, rega

261 trolling for time to presentation, VA before endophthalmitis was correlated significantly with VA at

262 Glaucoma drainage implant-associated endophthalmitis was correlated with poor visual outcome.

263 The diagnosis of endophthalmitis was defined as severe intraocular inflam

264 Endophthalmitis was defined clinically according to each

265 Patients in whom endophthalmitis was diagnosed following an intraocular p

266 nificantly lower rate of acute postoperative endophthalmitis was found in group 2 versus group 1 (0.0

267 Treatment for presumed bacterial endophthalmitis was given initially in 14 patients (88%)

268 The incidence of noninfectious endophthalmitis was higher for bevacizumab (8/9931, 0.08

269 The risk of endophthalmitis was low even without pre/post-operative

270 Bacterial endogenous endophthalmitis was observed in approximately 1 in 2000

271 increase in the likelihood of treatment for endophthalmitis was observed with increasing vitreous op

272 No endophthalmitis was reported.

273 g was found following 7.9% of injections; no endophthalmitis was reported.

274 Endophthalmitis was secondary to an endogenous source in

275 ion in cases that developed culture-positive endophthalmitis was significantly worse in the No Talkin

276 e 0.05% or 0.1% for prophylaxis of infective endophthalmitis was undertaken.

277 12-month VA in infectious and noninfectious endophthalmitis was within +/-2 lines of before endophth

278 data from patients with filtering-associated endophthalmitis were also collected and analyzed.

279 Patients with endophthalmitis were culture positive for bacteria in 66

280 eated multiple times for the same episode of endophthalmitis were excluded.

281 Sixteen cases of oral flora-associated endophthalmitis were found in the No Talking group (1 in

282 Odds of endogenous endophthalmitis were higher for premature and low-birthw

283 Thirty cases (0.7%) of GDI endophthalmitis were identified among 4073 GDIs performe

284 Three cases of endophthalmitis were identified with 1 culture-positive

285 injections performed, 60 cases (0.0293%) of endophthalmitis were identified, 18 of which were cultur

286 7, an estimated 291 total cases of infantile endophthalmitis were identified, in comparison with 140

287 ulture-proven or clinical evidence of fungal endophthalmitis were included.

288 tis who underwent ultrasound to evaluate for endophthalmitis were included.

289 Charts of patients with endophthalmitis were individually reviewed, and informat

290 Eyes with endogenous endophthalmitis were less likely to receive oral steroid

291 l steroids, whereas patients with endogenous endophthalmitis were less likely to receive oral steroid

292 atients undergoing either PK or EK, rates of endophthalmitis were low for both procedures and signifi

293 Eyes with glaucoma drainage device-related endophthalmitis were more likely to have a delayed prese

294 isual outcomes of Staphylococcus epidermidis endophthalmitis were no different than those of pathogen

295 ed in this cohort, the most common causes of endophthalmitis were postcataract extraction surgery (n

296 Fungal and bacterial endophthalmitis were seen in 37% (n = 25) and 43% (n = 2

297 he first reported case of Turicella otitidis endophthalmitis, which is notable for a delayed presenta

298 tion in ocular bacterial infections, such as endophthalmitis, which often cause blindness is not know

299 We found higher rates of noninfectious endophthalmitis with bevacizumab compared with ranibizum

300 The rate of endophthalmitis within 3 months after cataract surgery w