ライフサイエンスコーパス: endoreplication

1 DNA replication without cell division (i.e., endoreplication).

2 rapped, immature oocytes that have undergone endoreplication.

3 ndergoing mitotic DNA replication as well as endoreplication.

4 nal cascade that is involved in Fzr-mediated endoreplication.

5 progression at G2 and promoting the onset of endoreplication.

6 d is then redistributed during the course of endoreplication.

7 itotic, but undergo extensive growth and DNA endoreplication.

8 nduced tension anisotropy stimulates ectopic endoreplication.

9 treplicative cell cycle arrest and increased endoreplication.

10 egetative growth by modulating cell size and endoreplication.

11 phasizing its role in linking cell shape and endoreplication.

12 ESE (SIM) gene, which encodes a repressor of endoreplication.

13 otic tissues, but has a lesser effect on DNA endoreplication.

14 ms that support the onset and progression of endoreplication.

15 prisingly, however, ORC1 is not required for endoreplication.

16 sphamide exposure from pathologic basal cell endoreplication.

17 sistent with their involvement in regulating endoreplication.

18 severe) regeneration defects and basal cell endoreplication 3 days after cyclophosphamide exposure v

19 se in their ability to grow and to carry out endoreplication, a modified cell cycle in which DNA repl

20 epithelium through regulation of epithelial endoreplication, a modified cell cycle that entails geno

21 on results in polyploidy as a consequence of endoreplication, a phenomenon that can occur in response

22 revealed that PGCCs primarily developed from endoreplication after exposure to sublethal concentratio

23 Switching to hormone-independent endoreplication after mating allows growth and secretion

24 Vpr-driven endoreplication also caused duplication of transcription

25 Endoreplication, also called endoreduplication, is a mod

26 Endoreplication, also known as endoreduplication, is a m

27 Endoreplication, also known as endoreduplication, is a p

28 mozygous loss of Wee1 resulting in decreased endoreplication, alveologenesis and milk production.

29 rs 5 and 36 as potent and robust inducers of endoreplication and acytokinetic mitosis.

30 nd differentiation by promoting MCC exit and endoreplication and by modulating aspects of the biogene

31 Our results support a dual role for LGO on endoreplication and cell expansion.

32 Surprisingly, although endoreplication and cell size are greatly reduced in lgo

33 ve a defect in two types of DNA replication, endoreplication and chorion gene amplification.

34 However, E type cyclins seem essential for endoreplication and exit from quiescence.

35 is required for sexual reproduction and for endoreplication and genome reduction of the progeny's so

36 d overcome chemotherapy resistance caused by endoreplication and genomic rearrangements.

37 A null mutation in dm results in attenuated endoreplication and growth arrest early in larval develo

38 We observe increased endoreplication and growth of larval tissues in these do

39 expression, we discovered that cardiomyocyte endoreplication and hypertrophic growth were negatively

40 tral control node and determinant of cardiac endoreplication and hypertrophy by rechanneling free mit

41 ecome multinucleated shortly after birth via endoreplication and interrupted mitosis, which persists

42 e metabolic underpinnings of disease-induced endoreplication and its link to morphologic growth are u

43 omal instability, indicating that inaccurate endoreplication and karyokinesis occur during MK polyplo

44 Thus, dMyc is required for endoreplication and larval growth.

45 damage accumulated during pregnancy governs endoreplication and milk production.

46 products of MTHFD1L function to support DNA endoreplication and pathologic growth.

47 rect coupling of deregulated energetics with endoreplication and pathologic overgrowth.

48 We demonstrate that in the processes of endoreplication and photomorphogenesis, LIP1 acts downst

49 that, in addition to proliferation, germline endoreplication and ploidy are also affected by the loss

50 ckdown of scaf increases subperineurial glia endoreplication and proliferation of perineurial glia in

51 phoblast giant cells, which normally undergo endoreplication and reach elevated ploidies, showed a ma

52 ed DNA synthesis, which led to cardiomyocyte endoreplication and replication stress-induced DNA damag

53 hile Vpr causes a G2 phase delay followed by endoreplication and reversion of cells into a "pseudo-G1

54 f PNCs per cell increases with the rounds of endoreplication and that PNCs split into doublets during

55 Finally, endoreplication and the accompanying changes in epitheli

56 required for light-controlled inhibition of endoreplication and tolerance to salt stress in Arabidop

57 ion of BLT results in an additional round of endoreplication, and blt mutants uncouple DNA content fr

58 yploid cells can originate from cell fusion, endoreplication, and cytokinesis failure.

59 ueled by a combination of polyploid mitosis, endoreplication, and depolyploidization.

60 or that plays a central role in establishing endoreplication, and is the founding member of the SIAME

61 r is required for and sufficient to drive EC endoreplication, and Ras/Raf signalling upregulates E2f1

62 Our results indicate that larval growth and endoreplication are coupled processes that, although lin

63 dMyc driven growth and endoreplication are strongly attenuated when the endocyc

64 increased ploidy and genome instability, and endoreplication) are known to involve the Hippo signalin

65 L is necessary and sufficient for nurse cell endoreplication arrest and induces both stabilization of

66 Together, we identify cardiometabolic endoreplication as a hitherto unknown mechanism dictatin

67 cystocytes do not undergo multiple rounds of endoreplication as the nurse cells do in a normal egg ch

68 O mice had evidence of pathologic basal cell endoreplication associated with absent phosphorylated ER

69 The latter is frequently accompanied by endoreplication, being an alternative cell cycle that re

70 promoting mitotic cell cycle (MCC) exit and endoreplication, both in response to developmental and e

71 his role, mutants in SCL28 displayed reduced endoreplication, both in roots and leaves.

72 hat Hkb plays a critical role in controlling endoreplication by regulating the transcription of key c

73 der cells form by spatiotemporally regulated endoreplication, caused primarily by cytokinesis failure

74 ei form tumor-like structures from continued endoreplication, cell growth and retinal differentiation

75 In endoreplication, cells with replicated genomes bypass mi

76 Blockade of VEGFR-3 promoted endoreplication consistently.

77 tion in nurse cells at the end of the unique endoreplication cycle 5 and repressing transcription of

78 One, the switch from the endoreplication cycle to a gene-amplification phase, dur

79 polyploid through an experimentally induced endoreplication cycle.

80 plication to mitosis is absent in Drosophila endoreplication cycles (endocycles), during which discre

81 Overall our results suggest that transient endoreplication cycles generate a diverse population of

82 We show that the endoreplication defect resulted from a failure to downre

83 essed all the phenotypes associated with the endoreplication defect.

84 depletion of Enok also partially rescued the endoreplication defects in Elg1-depleted nurse cells.

85 ntrast to its dramatic effects on growth and endoreplication, dMyc is dispensable for the mitotic div

86 ton may provide a temporal cue ensuring that endoreplication does not begin until the cells have fini

87 trate that PCNA-POLD1-mediated cardiomyocyte endoreplication drives hypertrophic cardiomyocyte growth

88 Endoreplication, duplication of the nuclear genome witho

89 replication stress couples proliferation and endoreplication during mammary gland alveologenesis.

90 e (CDK) inhibitors and is a key regulator of endoreplication during the development of trichomes (sho

91 nt and for normal cell-cycle progression and endoreplication during the diploid sporophyte phase.

92 t involves distal-to-proximal progression of endoreplication (endocycle), whereas hkb mutant SG cells

93 n homolog Cdh1 function as key regulators of endoreplication entrance by activating the anaphase-prom

94 Furthermore, endoreplication from G2 phase is independent of p53 cont

95 Endoreplication from G2 phase lacks all hallmarks of mit

96 enance proteins are apparently essential for endoreplication, implying that some aspects of initiatio

97 ependent EcR signalling, which drives genome endoreplication in a subset of adult SCs.

98 the plant cell cycle, highlight the role of endoreplication in cell wall composition, and discuss re

99 aining CDK complexes in vivo, thus promoting endoreplication in developing Arabidopsis trichomes.

100 ion factor Myc acts downstream of Fzr during endoreplication in Drosophila salivary gland.

101 n factors that are not strictly required for endoreplication in Drosophila.

102 nd apoptotic rates of myoblasts, and display endoreplication in residual myotubes.

103 t of aberrant cell cycles in mutant strains: endoreplication in the clb1-5Delta strain(6) and periodi

104 docycle in these cells; Tec29 must delay DNA endoreplication in the salivary placode cells until they

105 to suppress mitosis as part of the switch to endoreplication in trichomes.

106 These cells adopted an endoreplication in which the genome replicates, mitosis

107 An important example is endoreplication, in which endocycling cells alternate be

108 ts, DNA replication is severely impaired and endoreplication is fully suppressed.

109 molecular mechanism underlying Fzr-mediated endoreplication is not completely understood.

110 Endoreplication is often associated with increased cell

111 t, the ability of dMyc to promote growth and endoreplication is only partly reduced when PI3K activit

112 olyploidy, driven by Notch signaling-induced endoreplication, is essential for the transformation of

113 Endoreplication, known as endocycle, is a variant of the

114 In Drosophila larvae, epithelial endoreplication leads to progressive changes in dendrite

115 se of cell fusion or abnormal cell division (endoreplication, mitotic slippage, or cytokinesis failur

116 ome are reminiscent of "mitotic slippage" or endoreplication observed in some other eukaryotes.

117 Endoreplication occurs exclusively in EBs and newborn EC

118 In addition, we discuss briefly how endoreplication occurs in response to certain physiologi

119 is necessary to repress excess branching and endoreplication of Arabidopsis trichomes.

120 This defines a new mechanism by which endoreplication of DNA can be triggered and maintained i

121 the entry of cells into mitosis and leads to endoreplication of DNA from G2 phase.

122 nd proper execution of the nurse cell cycle (endoreplication of DNA) and the oocyte cell cycle (karyo

123 es show that KDM5 functions by promoting the endoreplication of prothoracic gland cells, a process th

124 ring a developmentally regulated switch from endoreplication of the entire genome to amplification of

125 cision of chromosome breakage sequences, and endoreplication of the new macronuclear genome and event

126 nuclear-specific DNA occurs independently of endoreplication of the new macronuclear genome that take

127 n days 6 and 10 post ovulation initiated the endoreplication of the uterine surface epithelium to for

128 However, endoreplication of trophoblast giant cells and megakaryo

129 ed in which the oocyte nucleus has undergone endoreplication often resulting in the formation of 16 n

130 s, providing an explanation for the distinct endoreplication parameters compared with Drosophila.

131 We hypothesized that targeting cardiomyocyte endoreplication pathways could reduce pathological myoca

132 Comparison with endoreplication pathways in Drosophila and mammals indic

133 Endoreplication plays important roles in both normal pla

134 Heart disease is characterized by endoreplication preceding cardiac hypertrophy.

135 Ttk overexpression stops endoreplication prematurely and alleviates the endocycle

136 e Fzr-H2Bub-Myc signaling cascade regulating endoreplication progression is conserved between insects

137 es also often undergo an additional round of endoreplication resulting in enlarged nuclei with ploidy

138 ns of the cell cycle, termed collectively as endoreplication, resulting in polyploid cells that suppo

139 cating regions occasionally fail to complete endoreplication, resulting in underreplicated domains of

140 that while acting synergistically to promote endoreplication, SIM and SMR1 play different roles in af

141 vae is accompanied by defects in mitosis and endoreplication similar to that associated with nutritio

142 r, less branched and undergo fewer rounds of endoreplication than wild-type trichomes.

143 etameres that proceed through many cycles of endoreplication, the cells that constitute the Tr2 branc

144 nisms all use similar components to initiate endoreplication, the components are deployed differently

145 the tumor-initiating cells normally undergo endoreplication to become polyploid.

146 mal and mesophyll cell layers, which undergo endoreplication to increment DNA content and cell size.

147 ibitor with a key function in the mitosis-to-endoreplication transition.

148 ct on mitosis prompted investigations of the endoreplication variant of the cell cycle.

149 NA synthesis, demonstrating that the lack of endoreplication was a cell-autonomous defect.

150 Cardiomyocyte endoreplication was assessed using flow cytometry and im

151 rotein that promotes a shift from mitosis to endoreplication was lower in abcb19 hypocotyls, and fluo

152 and dMyc (Diminutive) are key regulators of endoreplication, which is necessary but not sufficient t

153 on but that cell division can substitute for endoreplication without affecting final organ size or gr

154 Drosophila larval tissues undergo endoreplication without cell division, and the latest re

155 istence of Cdk2 activity in G2 cells induces endoreplication without mitosis.