ライフサイエンスコーパス: endoribonuclease

1 is a highly conserved tRNA 3'-end processing endoribonuclease.

2 ltiple copies in both Csm complexes, acts as endoribonuclease.

3 terspaced short palindromic repeats (CRISPR) endoribonuclease.

4 ation and help to identify new roles of this endoribonuclease.

5 dent on Ire1, an ER membrane-resident kinase/endoribonuclease.

6 NA component of mitochondrial RNA processing endoribonuclease.

7 iated with G3BP, a phosphorylation-dependent endoribonuclease.

8 resence of Mg(2+), RNase BN was primarily an endoribonuclease.

9 y high production and catalytic rates of the endoribonuclease.

10 iated by a bifunctional transmembrane kinase/endoribonuclease.

11 U(L)41 gene of herpes simplex virus 1 is an endoribonuclease.

12 ial toxin that is an ssRNA- and ACA-specific endoribonuclease.

13 kinase site that allosterically inhibit the endoribonuclease.

14 que example of a protein-guided programmable endoribonuclease.

15 fect of HBx protein on activity of the Dicer endoribonuclease.

16 t shutoff protein (vhs), a virion-associated endoribonuclease.

17 d by RNase L and other metal-ion-independent endoribonucleases.

18 hed by a combination of exoribonucleases and endoribonucleases.

19 cerevisiae model host, we tested eight known endoribonucleases.

20 cessing by a large family of CRISPR-specific endoribonucleases.

21 '-truncated viral RNAs are generated by host endoribonucleases.

22 t into the mysterious coupling of kinase and endoribonuclease activities in the oldest, most-conserve

23 proteins with greatly reduced but detectable endoribonuclease activities.

24 IRE1alpha to activate its protein kinase and endoribonuclease activities.

25 s) protein of herpes simplex virus (HSV) has endoribonuclease activity and rapidly reduces protein sy

26 SV-2 infection in a manner that requires vhs endoribonuclease activity and that, befitting this abili

27 IRE1alpha endoribonuclease activity controls the stability of mRNA

28 alysis of the mechanism shows that IRE1alpha endoribonuclease activity decreased PER1 mRNA in tumor c

29 Finally, the effect of 5'-C-methylation on endoribonuclease activity has been explained.

30 Here, we test the requirement for vhs endoribonuclease activity in disruption of SG formation.

31 ivo, we investigated the requirement for vhs endoribonuclease activity in disruption of SG formation.

32 erization and phosphorylation, and inhibited endoribonuclease activity in human cells.

33 This enzyme is the main endoribonuclease activity in plant cells and localizes t

34 that the dDis3 N-terminus is sufficient for endoribonuclease activity in vitro and that proper N-ter

35 inant RB47 including the NCL did not display endoribonuclease activity in vitro, versions lacking the

36 yme 1alpha (IRE1alpha), while activating its endoribonuclease activity in vitro.

37 Our studies demonstrate that endoribonuclease activity is required for vhs to disrupt

38 Together these data indicate that endoribonuclease activity must be maintained in order fo

39 depend on antisense RNA and might implicate endoribonuclease activity of CSP41a.

40 Intracellular CD24 inhibits the specific endoribonuclease activity of G3BP toward BART mRNA in st

41 additional transcripts, which shows that the endoribonuclease activity of GhoS has been broadened as

42 The endoribonuclease activity of IRE1 appears to be required

43 ds MazF(Sa) to form a complex to inhibit the endoribonuclease activity of MazF(Sa).

44 o better define the relationship between the endoribonuclease activity of murine hepatitis virus (MHV

45 The endoribonuclease activity of the mouse hepatitis virus (

46 The endoribonuclease activity of the SARS-CoV Nsp15 (sNsp15)

47 clock PER1 mRNA as a novel substrate of the endoribonuclease activity of the UPR sensor IRE1alpha.

48 VapC-mt4 exhibited sequence-specific endoribonuclease activity on mRNA templates at ACGC and

49 ow that Sinorhizobium meliloti YbeY exhibits endoribonuclease activity on single-stranded RNA substra

50 Recombinant human LACTB2 displayed robust endoribonuclease activity on ssRNA with a preference for

51 We present evidence that ablation of vhs endoribonuclease activity results in defects in vhs-medi

52 indicating that YoeB by itself does not have endoribonuclease activity under the conditions used.

53 indicating that YafO by itself does not have endoribonuclease activity under the conditions used.

54 ddition to nitric oxide, stimulation of IRE1 endoribonuclease activity with the flavonol quercetin le

55 xosome has both 3' to 5' exoribonuclease and endoribonuclease activity, and the available evidence su

56 he dimer in solution and severely diminished endoribonuclease activity, indicating that the dimer is

57 as impaired in hexamer formation and had low endoribonuclease activity, suggesting that oligomerizati

58 the point mutation D215N, which ablates its endoribonuclease activity, to disrupt SG formation in bo

59 IRE1 also has an endoribonuclease activity, which initiates a non-convent

60 unconventional splicing mechanism using its endoribonuclease activity.

61 binding and directly activates the latter's endoribonuclease activity.

62 ters, IRE1 dephosphorylation, and decline in endoribonuclease activity.

63 gesting that oligomerization is required for endoribonuclease activity.

64 e active site, were significantly reduced in endoribonuclease activity.

65 nd Rrp44/Dis3, a subunit that also catalyzes endoribonuclease activity.

66 loroplast to regulate the activation of RB47 endoribonuclease activity.

67 ly, that SG disassembly can be driven by vhs endoribonuclease activity.

68 ied from chloroplasts in association with an endoribonuclease activity; however, protein sequencing f

69 tly process an rAP site in DNA and have weak endoribonuclease and 3'-exonuclease activities on r8oxoG

70 how RNase BN can act as both an exo- and an endoribonuclease and also demonstrate that its exoribonu

71 istic insight for the regulation of the Las1 endoribonuclease and identifies the tetrameric Grc3/Las1

72 icolor absB gene encodes an RNase III family endoribonuclease and is normally essential for antibioti

73 ytically inert but associates with Rrp44, an endoribonuclease and processive 3'-->5' exoribonuclease,

74 RNA cleavage by some endoribonucleases and self-cleaving ribozymes produces R

75 '-->3' phosphodiesterases, a purine-specific endoribonuclease, and a reverse transcriptase.

76 E1alpha), an ER transmembrane protein kinase/endoribonuclease, and ER-resident eukaryotic translation

77 em is a sequence- and single-strand-specific endoribonuclease, and many studies have led to the propo

78 YbeY, a previously unidentified endoribonuclease, and the exonuclease RNase R act togeth

79 NA fragments (tRFs) by the stress-responsive endoribonuclease angiogenin, thereby uncovering a role f

80 nduced silencing complex (RISC), wherein the endoribonuclease Argonaute and single-stranded small int

81 lease L (RNase L) is a metal-ion-independent endoribonuclease associated with antiviral and antibacte

82 essing was independent of the broad-spectrum endoribonucleases associated with mRNA turnover and stil

83 The Las1L endoribonuclease associates with the Nol9 polynucleotide

84 red mammalian genetic systems and develop an endoribonuclease-based feedforward controller that can a

85 Here, we show that Drosha, an endoribonuclease best known for its role in the biogenes

86 trated the involvement of the RNase III-like endoribonuclease, Bs-RNase III, in scRNA processing.

87 IL-17-mediated signaling, requiring MCPIP1's endoribonuclease but not deubiquitinase domain.

88 brane and that toxin MqsR (a 5'-GCU-specific endoribonuclease) causes membrane damage in a GhoT-depen

89 w temperature, induction of an mRNA-specific endoribonuclease causing host cell growth arrest, and cu

90 DICER1 is an RNase III endoribonuclease central to miRNA biogenesis, and germli

91 ily are double-stranded RNA (dsRNA) specific endoribonucleases characterized by a signature motif in

92 Altogether, results reveal a site-specific endoribonuclease cleavage event that seems to depend on

93 quency and location of metal-ion-independent endoribonuclease cleavage sites within host and viral RN

94 Our results establish that Grc3 drives Las1 endoribonuclease cleavage to its targeted C2 site both i

95 Studies with cells lacking RNase L, the endoribonuclease component of the interferon-regulated 2

96 P) is an essential, evolutionarily conserved endoribonuclease composed of 10 different protein subuni

97 line mutations in DICER1, a gene encoding an endoribonuclease critical to the generation of small non

98 Moreover, trans-acting endoribonucleases, Csx1 or Csm6, can promote the Type II

99 as aeruginosa, crRNA biogenesis requires the endoribonuclease Csy4, which binds and cleaves the repet

100 ality in ck-RNAi, we designed a novel CRISPR endoribonuclease Csy4/GUS reporter that enabled in situ

101 Here, we identify the endoribonuclease (Csy4) responsible for CRISPR transcrip

102 In addition to the endoribonuclease Dcr1, RNAi in S. pombe requires two int

103 ctions, the virion host shutoff (Vhs) (UL41) endoribonuclease degrades many cellular and viral mRNAs.

104 implex virus (HSV) virion host shutoff (Vhs) endoribonuclease degrades many host and viral mRNAs.

105 ase BN acted as either an exoribonuclease or endoribonuclease depending on the nature of the added di

106 CoVs encode an endoribonuclease designated EndoU that facilitates evasi

107 ficant changes of argonaute (AGO1, AGO2) and endoribonuclease dicer (DICER1) transcripts, and endogen

108 We have previously demonstrated that the endoribonuclease DICER facilitates chromatin decondensat

109 The endoribonuclease Dicer is a key component of the human R

110 The endoribonuclease dicer is a major component of the miRNA

111 anscriptional silencing) complex, and 3) the endoribonuclease Dicer ortholog Dcr1.

112 are generated predominantly by the type III endoribonuclease Dicer-like 1 (DCL1) but do not require

113 The endoribonuclease, Dicer, is indispensable for generating

114 RNase BN, a member of the RNase Z family of endoribonucleases, differs from other family members in

115 arget in MM using a small-molecule IRE1alpha endoribonuclease domain inhibitor MKC-3946.

116 of XBP1 splicing by inhibition of IRE1alpha endoribonuclease domain is a potential therapeutic optio

117 on loop phosphorylation in activation of the endoribonuclease domain of Ire1.

118 Rrp44p also contains an endoribonuclease domain.

119 t containing the unique cytosolic kinase and endoribonuclease domains of human IRE1alpha (hIRE1alpha-

120 a dominant viral antagonist, the coronavirus endoribonuclease, dramatically alters the host response

121 abundance due to efficient processing by the endoribonuclease DROSHA, which initiates miRNA biogenesi

122 Here we show that the endoribonuclease E (RNaseE) and RNA helicase B (RhlB) co

123 Escherichia coli endoribonuclease E has a major influence on gene express

124 mRNA interferases are sequence-specific endoribonucleases encoded by the toxin-antitoxin systems

125 uch as MazF and ChpBK, are sequence-specific endoribonucleases encoded by toxin-antitoxin (TA) system

126 mRNA interferases are sequence-specific endoribonucleases encoded by toxin-antitoxin (TA) system

127 We found that deletion of the endoribonuclease-encoding Dicer1 specifically in Th17 ce

128 Previously, we reported that an endoribonuclease (EndoU) encoded by murine coronavirus p

129 (DUB) within nonstructural protein 3 or the endoribonuclease (EndoU) within nonstructural protein 15

130 We found that mutating a viral endoribonuclease, EndoU, results in a virus that activat

131 mut) and the other containing an inactivated endoribonuclease (EndoUmut).

132 ployed TIER-seq (transiently inactivating an endoribonuclease followed by RNA-seq) to profile cleavag

133 ER-seq analysis (transiently-inactivating-an-endoribonuclease-followed-by-RNA-seq) revealed ~25,000 R

134 Ribonuclease (RNase) P is a site-specific endoribonuclease found in all kingdoms of life.

135 RNA against degradation by copies of the Vhs endoribonuclease from infecting virions and greatly enha

136 ibonuclease Sa (RNase Sa), a small, guanylyl-endoribonuclease from Streptomyces aureofaciens, was com

137 Restrictocin and related fungal endoribonucleases from the alpha-sarcin family site-spec

138 ere discovered to allosterically inhibit the endoribonuclease function of the dual kinase-endoribonuc

139 the IRE1alpha protein and activation of the endoribonuclease function.

140 d III CRISPR/Cas systems, the Cas6 family of endoribonucleases generates functional CRISPR-derived RN

141 The RNase E/G family of endoribonucleases has a central role in RNA degradation

142 to RNase L and other single-strand specific endoribonucleases, (ii) RNase L-dependent and RNase L-in

143 We demonstrate that the endoribonuclease III, DICER1, contributes to the establi

144 s has been reported to be RNase E, the major endoribonuclease in enterica bacteria.

145 RNase Y is a recently identified endoribonuclease in Gram-positive bacteria, and an RNase

146 s intact 7SL RNA, with 7SLrem produced by an endoribonuclease in the absence of NC.

147 Germline truncating mutations in DICER1, an endoribonuclease in the RNase III family that is essenti

148 ssociated with miR biogenesis, and Dicer, an endoribonuclease in the RNaseIII family associated with

149 This phenotype is induced by viral endoribonucleases, including SOX in Kaposi's sarcoma-ass

150 says suggest that the toxin is an Mg-enabled endoribonuclease, inhibited by the antitoxin.

151 analogs are the first reported specific IRE1 endoribonuclease inhibitors.

152 The ER-resident transmembrane kinase-endoribonuclease inositol-requiring enzyme 1 (IRE1) is t

153 served ER-resident UPR regulator, the kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1), is

154 endoribonuclease function of the dual kinase-endoribonuclease inositol-requiring enzyme 1alpha (IRE1a

155 d by the ER transmembrane protein kinase and endoribonuclease inositol-requiring enzyme-1alpha (IRE1a

156 mutations in Dicer1, a type III cytoplasmic endoribonuclease involved in small non-coding RNA genesi

157 itous and essential site-specific eukaryotic endoribonuclease involved in the metabolism of a wide ra

158 To identify host endoribonucleases involved in degradation of Tomato bush

159 The bifunctional protein kinase-endoribonuclease Ire1 initiates splicing of the mRNA for

160 In S. pombe, the ER membrane-resident kinase/endoribonuclease Ire1 utilizes a mechanism of selective

161 ivates the bifunctional transmembrane kinase/endoribonuclease Ire1.

162 ls and eosinophils selectively activated the endoribonuclease IRE1alpha and spliced Xbp1 mRNA without

163 mic reticulum (ER) stress, the transmembrane endoribonuclease Ire1alpha performs mRNA cleavage reacti

164 acillus subtilis have demonstrated that this endoribonuclease is essential for the maturation of tRNA

165 The bacteriophage T4-encoded RegB endoribonuclease is produced during the early stage of p

166 navirus nonstructural protein 15 (nsp15), an endoribonuclease, is required for evasion of dsRNA senso

167 E1alpha), an ER transmembrane protein kinase/endoribonuclease, is required to maintain hepatic lipid

168 Results indicated that endoribonuclease J2 contributes significantly to the deg

169 ka virus (ZIKV) interacts with the antiviral endoribonuclease L (RNase L) pathway during infection.

170 The protein was further identified as an endoribonuclease L-PSP (Liver-Perchloric acid-soluble pr

171 2'-5'-oligoadenylate and thus activation of endoribonuclease L.

172 Accordingly, overexpression of the Ngl2p endoribonuclease led to an increased accumulation of cle

173 iptome degradation by the sequence-dependent endoribonuclease MazF, to a synthetic circuit can increa

174 In this article, we show that the endoribonuclease MCP-1-induced protein 1 (MCPIP1; also k

175 The monocyte endoribonuclease MCPIP1 negatively regulates inflammatio

176 s in the ER and deploys a cytoplasmic kinase-endoribonuclease module to activate the transcription fa

177 orts protein secretion by deploying a kinase-endoribonuclease module to activate the transcription fa

178 , RNA interference-mediated knockdown of the endoribonuclease MRP did not result in a clear defect in

179 Analysis of DeltaermC mRNA processing in endoribonuclease mutant strains showed that this process

180 that postsynaptic knockdown of dicer-1, the endoribonuclease necessary for microRNA synthesis, leads

181 ns a novel uridylate-specific Mn2+-dependent endoribonuclease (NendoU).

182 e and respiratory syndrome virus (PRRSV) RNA endoribonuclease nsp11 belongs to the XendoU superfamily

183 Coronaviruses encode an endoribonuclease, Nsp15, which has a poorly defined role

184 d-RNA-activated protein kinase (PKR) and the endoribonuclease of the 2',5'-oligoadenylate synthetase-

185 A new study reveals that a calcium-activated endoribonuclease of the EndoU protein family promotes th

186 s both a distributive exoribonuclease and an endoribonuclease on model RNA substrates and to be inhib

187 at the HEPN domain of the adenosine-specific endoribonuclease, Pfu Csx1, degrades cOA signaling molec

188 The PRRSV nsp11 endoribonuclease plays a vital role in arterivirus repli

189 liberated from the complex, YoeB acts as an endoribonuclease, preferentially cleaving 3' of purine n

190 Cept1 endoribonuclease-prepared siRNA decreased PPARalpha phos

191 is an ankyrin repeat domain-containing dual endoribonuclease-pseudokinase that is activated by unusu

192 We show that RDE-1 can instead recruit an endoribonuclease, RDE-8, to target RNA.

193 differentiation and acted together with the endoribonuclease regnase-1 to repress target mRNA encodi

194 While IRE1 has been identified as the endoribonuclease required for cleavage of this mRNA, the

195 mily of double-stranded RNA (dsRNA)-specific endoribonucleases required for RNA maturation and gene r

196 Here, we report that the essential Las1 endoribonuclease requires its binding partner, the polyn

197 cer, recent studies suggest that DICER1, the endoribonuclease responsible for miRNA genesis, also pla

198 Ribonuclease P (RNase P) is a Mg2+-dependent endoribonuclease responsible for the 5'-maturation of tr

199 activation of RNase Y, a recently identified endoribonuclease, revealed a role in processing and degr

200 omponent of the mitochondrial RNA processing endoribonuclease (RMRP) give rise to the autosomal reces

201 NA Component of Mitochondrial RNA Processing Endoribonuclease (RMRP) in cellular physiology and disea

202 bacteria, RhlB associates with the essential endoribonuclease RNase E as part of the multi-enzyme RNA

203 o profile cleavage products of the essential endoribonuclease RNase E in Salmonella enterica.

204 The endoribonuclease RNase E is a key enzyme in RNA metaboli

205 The Escherichia coli endoribonuclease RNase E is central to the processing an

206 ternary complex of Hfq, sRNA and mRNA guides endoribonuclease RNase E to initiate turnover of both th

207 component of the degradosome complex is the endoribonuclease RNase E, a multidomain protein composed

208 rotein acts as an inhibitor of the essential endoribonuclease RNase E, and we demonstrated that ectop

209 enzymes (ribonucleases; RNases) such as the endoribonuclease RNase E, frequently play critical roles

210 nts of the C. crescentus degradosome are the endoribonuclease RNase E, the exoribonuclease polynucleo

211 teraction with the scaffolding domain of the endoribonuclease RNase E.

212 ly reversed by overexpression of the related endoribonuclease RNase G or by mutation of the gene enco

213 ) elicit cleavage of the targeted RNA by the endoribonuclease RNase H1, whereas siRNAs mediate cleava

214 recent findings that the narrow-specificity endoribonuclease RNase III and the 5' exonuclease RNase

215 The endoribonuclease RNase III cleaves double stranded RNAs,

216 age including the double-strand RNA-specific endoribonuclease RNase III.

217 The exo- and endoribonuclease RNase J, the only prokaryotic 5'->3' ri

218 However, the antiviral endoribonuclease RNase L also alters SG formation, where

219 f OAS, to prevent activation of the cellular endoribonuclease RNase L and consequently block viral RN

220 The endoribonuclease RNase L is a key mediator of IFN induct

221 hat senses double-stranded RNA and activates endoribonuclease RNase L to cleave viral and cellular RN

222 o activation of the interferon (IFN)-induced endoribonuclease RNase L, which results in degradation o

223 racellular RNA decay by the pseudokinase and endoribonuclease RNase L.

224 of intracellular RNA by the kinase homology endoribonuclease RNase L.

225 tivate a ubiquitously expressed pseudokinase/endoribonuclease RNase L.

226 ther, this work suggests a role for the host endoribonuclease RNase MRP in viral RNA degradation and

227 P RNA is the RNA subunit of a ubiquitous endoribonuclease RNase P that consists of one RNA subuni

228 Here, we identified the lysosomal endoribonuclease RNase T2 as a non-redundant upstream co

229 and Rpp25 are two key subunits of the human endoribonucleases RNase P and MRP.

230 omain of IRE1alpha, inhibits both kinase and endoribonuclease (RNase) activities of the stress sensor

231 ensory lumenal domain, and tandem kinase and endoribonuclease (RNase) cytoplasmic domains.

232 homo-oligomerization of its cytosolic kinase/endoribonuclease (RNase) domains to activate mRNA splici

233 nd conformational changes to the cytoplasmic endoribonuclease (RNase) domains, which render them func

234 We found that the ER transmembrane kinase/endoribonuclease (RNase) IRE1alpha is a key component of

235 The endoribonuclease (RNase) Las1 and the polynucleotide kin

236 ansducer IRE1alpha is a transmembrane kinase endoribonuclease (RNase) that cleaves mRNA substrates to

237 inositol requiring enzyme 1alpha (IRE1alpha) endoribonuclease (RNase), a key mediator of the UPR, cle

238 ivates IRE1alpha, an ER transmembrane kinase-endoribonuclease (RNase).

239 , 3' maturation of tRNAs is catalyzed by the endoribonuclease, RNase BN/RNase Z, which cleaves after

240 Many sRNAs recruit the endoribonuclease, RNase E, to facilitate processing of m

241 on small regulatory RNA (sRNA) and the major endoribonuclease, RNase E.

242 ere we show that activation of the antiviral endoribonuclease, RNase L, by 2',5'-linked oligoadenylat

243 protein components are shared with a related endoribonuclease, RNase P.

244 as1 cross talk draws unexpected parallels to endoribonucleases RNaseL and Ire1, and establishes Grc3/

245 MD targets, despite the lack of the metazoan endoribonuclease SMG6 in plants.

246 In metazoans, cleavage by the endoribonuclease SMG6 is often the first degradative eve

247 best-characterized activity of vhs is as an endoribonuclease specific for mRNA in vivo, we investiga

248 an antitoxin from a type V system (GhoS, an endoribonuclease specific for the mRNA of the toxin GhoT

249 tRNA in many organisms is carried out by an endoribonuclease termed RNase Z or 3'-tRNase, which clea

250 during maturation of tRNA is catalyzed by an endoribonuclease, termed RNase Z.

251 HSV) virion host shutoff (Vhs) protein is an endoribonuclease that accelerates decay of many host and

252 es IRE1alpha, an ER transmembrane kinase and endoribonuclease that activates the transcription factor

253 s been shown to be a sequence-specific (ACA) endoribonuclease that cleaves cellular mRNAs and effecti

254 entified Pyrococcus furiosus Cas6 as a novel endoribonuclease that cleaves CRISPR RNAs within the rep

255 strate that ChpBK is a new sequence-specific endoribonuclease that cleaves mRNAs both in vivo and in

256 Staphylococcus aureus is a sequence-specific endoribonuclease that cleaves the majority of the mRNAs

257 RNase L is an antiviral endoribonuclease that cleaves viral mRNAs after single-s

258 Las1 is a recently discovered endoribonuclease that collaborates with Grc3-Rat1-Rai1 t

259 ondrial RNA processing (MRP) is an essential endoribonuclease that consists of one RNA component and

260 the virion host shutoff protein (VHS) is an endoribonuclease that degrades mRNA.

261 Y as a zinc-dependent single-strand specific endoribonuclease that functions in 16S rRNA processing i

262 sing (MRP) is an essential ribonucleoprotein endoribonuclease that functions in the degradation of sp

263 ibonuclease E (RNase E) is a multifunctional endoribonuclease that has been evolutionarily conserved

264 Restrictocin is a site-specific endoribonuclease that inactivates ribosomes by cleaving

265 MazFSa is a sequence-specific endoribonuclease that inhibits the growth of S. aureus a

266 RNase L is an IFN-regulated endoribonuclease that is activated in virus-infected cel

267 RNase E of Escherichia coli is an essential endoribonuclease that is involved in many aspects of RNA

268 her, this study discovered that LACTB2 is an endoribonuclease that is involved in the turnover of mit

269 Herpes simplex virus 1 (HSV-1) encodes an endoribonuclease that is responsible for the shutoff of

270 osome biogenesis factor Las1 is an essential endoribonuclease that is well-conserved across eukaryote

271 RNase L is an endoribonuclease that mediates diverse antiproliferative

272 ase inositol-requiring protein-1 (IRE-1), an endoribonuclease that mediates unconventional splicing,

273 Furthermore, RNase P, an endoribonuclease that normally generates the mature 5'-e

274 sp15 (nonstructural protein 15), a hexameric endoribonuclease that preferentially cleaves 3' of uridi

275 n-structural protein 15 (Nsp15), a hexameric endoribonuclease that preferentially cleaves at uridine

276 with mammalian MARF1, a recently identified endoribonuclease that promotes oogenesis and contains a

277 C3PO is a Mg2+-dependent endoribonuclease that promotes RISC activation by removi

278 U(L)41 gene of herpes simplex virus 1 is an endoribonuclease that selectively degrades mRNAs during

279 e P 1 (PRORP1) in Arabidopsis thaliana is an endoribonuclease that uses its PPR domain to recognize p

280 Remarkably, these VapCs are all endoribonucleases that cleave RNAs essential for decodin

281 re than half of these encode VapC PIN domain endoribonucleases that inhibit cell growth by unknown me

282 mutant at 45 degrees C, making YbeY the only endoribonuclease to be implicated in the critically impo

283 tomics and purified MqsR, we determined that endoribonuclease toxin MqsR degrades YgiS mRNA, which en

284 coli strain lacking ten TA systems encoding endoribonuclease toxins is not affected following exposu

285 quired for accurate substrate recognition by endoribonuclease toxins, definitive RNA target identific

286 multifunctional DNA/RNA-binding protein, and endoribonuclease UK114 (UK).

287 of the alpha-sarcin family of site-specific endoribonucleases, uses electrostatic interactions to bi

288 By using a sequence-specific endoribonuclease, we show that the rare arginine codons,

289 nd purified to homogeneity acts as bona fide endoribonuclease when tested on in vitro transcribed IEX

290 MazF(Sa) is a novel sequence-specific endoribonuclease which cleaves mRNA to inhibit protein s

291 vening spacers through the function of Cas6e endoribonuclease, which cleaves at specific positions of

292 ss is sensed by Ire1, a transmembrane kinase/endoribonuclease, which initiates the non-conventional s

293 d that the antiviral effector 2-5A-dependent endoribonuclease, which is not an ISG in humans, is high

294 We demonstrate that HigB is an endoribonuclease whose enzymatic activity is dependent o

295 YbeY(Las) was characterized as an endoribonuclease with activity on 3' and 5' termini of 1

296 It was previously characterized as an endoribonuclease with preference for single-stranded (ss

297 on-structural protein 15 is a Mn2+-dependent endoribonuclease with specificity for cleavage at uridyl

298 RNase Z(L) (dRNaseZ) belongs to a family of endoribonucleases with a major role in tRNA 3'-end proce

299 ver requires knowledge of cleavages by major endoribonucleases within a living cell.

300 Single-strand specific endoribonuclease YbeY has been shown to play an importan