ライフサイエンスコーパス: endothelial barrier

1 ns are crucial for correct regulation of the endothelial barrier.

2 determined by their permeability across the endothelial barrier.

3 ility and contractility at the inner retinal endothelial barrier.

4 s comprising a sharp S1P gradient across the endothelial barrier.

5 abling inflammatory mediator flux across the endothelial barrier.

6 t lead to profound dysregulation of the lung endothelial barrier.

7 ers, resulting thereby in formation of leaky endothelial barrier.

8 s) are required for formation of restrictive endothelial barrier.

9 2+) stores, preventing the disruption of the endothelial barrier.

10 ing Ca(2+) entry-dependent disruption of the endothelial barrier.

11 ating recovery of the VE-cadherin-controlled endothelial barrier.

12 tating their transmigration of the lymphatic endothelial barrier.

13 ter and molecular tracers across the retinal endothelial barrier.

14 of adherens junctions, and disruption of the endothelial barrier.

15 eby establish the characteristic restrictive endothelial barrier.

16 passive movement of LDL across a compromised endothelial barrier.

17 aling and contribute to the integrity of the endothelial barrier.

18 emokines influencing the permeability of the endothelial barrier.

19 ncreased contractility and disruption of the endothelial barrier.

20 tion of VE-cadherin and for breakdown of the endothelial barrier.

21 1 controls membrane spreading and stabilizes endothelial barriers.

22 ctor by promoting invasion of epithelial and endothelial barriers.

23 that correlates with increased leakiness of endothelial barriers.

24 dly inhibited monocyte transmigration across endothelial barriers.

25 ling pathways regulating regeneration of the endothelial barrier after inflammatory vascular injury.

26 KBP51 axis to inhibit I(SOC) and protect the endothelial barrier against calcium entry-induced disrup

27 ncreased proficiency to transmigrate through endothelial barrier (an obligatory step for vascular dis

28 ry requires the reestablishment of an intact endothelial barrier and a functional alveolar epithelial

29 hat it is involved both in modulation of the endothelial barrier and in EC activation.

30 everity by damaging the pulmonary epithelial-endothelial barrier and increasing pulmonary oedema.

31 C) has previously been shown to tighten the endothelial barrier and maintain barrier integrity durin

32 e important for insulin transport across the endothelial barrier and mediate insulin's actions in mus

33 ights into the biomechanical function of the endothelial barrier and suggests similar opportunities f

34 escribe a new mechanism regulating the tumor endothelial barrier and T cell infiltration into tumors.

35 s been shown to control the integrity of the endothelial barrier and to support neutrophil transendot

36 circulating tumor cells must destabilize the endothelial barrier and transmigrate across the vessel w

37 through lymph nodes (LNs) requires crossing endothelial barriers and chemoattractant-triggered cell

38 ived APCs in the migration of T cells across endothelial barriers and have important implications for

39 /165 and VEGF165b in both brain and nonbrain endothelial barrier, angiogenesis, and neutrophil migrat

40 on of inflammatory cells across the vascular endothelial barrier are crucial factors in the pathogene

41 t demonstrated increased permeability of the endothelial barrier as evidenced by Evans blue and sodiu

42 n in vitro model of the pulmonary epithelial-endothelial barrier as well as an in vivo murine model o

43 on of human neutrophils to inflamed vascular endothelial barriers as well as their subsequent transmi

44 (Th17) lymphocyte transmigration across the endothelial barrier at the expense of T regulatory cells

45 Defects in the endothelial barrier become an initiating factor in sever

46 The integrity of the endothelial barrier between circulating blood and tissue

47 ant link between abnormalities in PVM/Ms and endothelial barrier breakdown from acoustic trauma to th

48 fection leading to systemic inflammation and endothelial barrier breakdown.

49 arably exaggerated permeability and enhanced endothelial barrier breakdown.

50 and adherens junction disassembly leading to endothelial barrier breakdown.

51 rophil extravasation requires opening of the endothelial barrier but does not necessarily cause plasm

52 to extravasate across a permeable capillary endothelial barrier, but not with gadofosveset, a blood-

53 of focal adherens junctions, disrupting the endothelial barrier by acting on H1R Galphaq-coupled rec

54 acity to promote tumor cell invasion through endothelial barriers by both direct and indirect mechani

55 key role in both vascular calcification and endothelial barrier damage observed in HGPS.

56 st phase but ameliorated the second phase of endothelial barrier disruption and apoptosis.

57 idate the KLF2-mediated pathways involved in endothelial barrier disruption and cytokine storm in exp

58 in mediating VE-cadherin internalization and endothelial barrier disruption and inflammation.

59 Lung vascular endothelial barrier disruption and the accompanying infl

60 ress syndrome (ARDS) is caused by widespread endothelial barrier disruption and uncontrolled cytokine

61 nitro-L-arginine methyl ester attenuated the endothelial barrier disruption in both phases.

62 Endothelial barrier disruption is a hallmark of multiple

63 Further, calcium entry-induced endothelial barrier disruption is decreased by S100A6 de

64 1 actin binding proteins in thrombin-induced endothelial barrier disruption is unveiled.

65 e, head trauma, or high altitude can lead to endothelial barrier disruption referred to as capillary

66 We previously showed that thrombin promotes endothelial barrier disruption through autophosphorylati

67 Importantly, CS-induced endothelial barrier disruption was attenuated by VEGFR2

68 s that regulates endosomal p38 signaling and endothelial barrier disruption.

69 the recovery process after thrombin-induced endothelial barrier disruption.

70 protein signaling of PAR1 and PAR1-mediated endothelial barrier disruption.

71 ased lung microvessel pressure and mediating endothelial barrier disruption.

72 transduction of mechanical stimuli inducing endothelial barrier disruption.

73 Due to disruption of the endothelial barrier during cold-ischemic storage and rep

74 roperty is central to the maintenance of the endothelial barrier during inflammation, the molecular m

75 hemolysis and free heme in circulation cause endothelial barrier dysfunction and are associated with

76 Thus, imatinib prevents endothelial barrier dysfunction and edema formation via

77 Here, we explored the effect of imatinib on endothelial barrier dysfunction and edema formation.

78 PK) in lipopolysaccharide (LPS)-induced lung endothelial barrier dysfunction and lung injury in vivo.

79 osure inhibits AMPK, thereby contributing to endothelial barrier dysfunction and lung injury.

80 n of Src greatly attenuated nmMLCK-dependent endothelial barrier dysfunction and monocyte migration.

81 ted RhoA activation involved in LPS-mediated endothelial barrier dysfunction and show the potential u

82 Tissue edema and endothelial barrier dysfunction as observed in sepsis an

83 Imatinib limited Arg-mediated endothelial barrier dysfunction by enhancing Rac1 activi

84 indicated that nmMLCK deficiency attenuated endothelial barrier dysfunction caused by thrombin, oxid

85 Thus, endothelial barrier dysfunction due to 3MC occurs throug

86 Cs and that this may contribute to pulmonary endothelial barrier dysfunction in HPAH patients.

87 Protein nitration is involved in the endothelial barrier dysfunction in LPS-exposed mice.

88 Inhibiting RhoA signaling restored endothelial barrier dysfunction in the dn-CREB-expressin

89 endothelial monolayers, imatinib attenuated endothelial barrier dysfunction induced by thrombin and

90 Endothelial barrier dysfunction is a central factor in t

91 Endothelial barrier dysfunction underlies chronic inflam

92 Vascular endothelial barrier dysfunction underlies diseases such

93 1P effectively could reverse alcohol-induced endothelial barrier dysfunction using both cultured endo

94 ve kinases revealed that imatinib attenuates endothelial barrier dysfunction via inhibition of Abl-re

95 age of MEK1/2 was necessary for LT to induce endothelial barrier dysfunction, and activated Tie-2 sig

96 ility to attenuate LPS-induced inflammation, endothelial barrier dysfunction, and acute lung injury (

97 ng activation of coagulation and complement, endothelial barrier dysfunction, and microangiopathy.

98 lular distribution were conducted to examine endothelial barrier dysfunction.

99 signaling for F-actin stress fiber inducing endothelial barrier dysfunction.

100 (Arg/Abl2), a previously unknown mediator of endothelial barrier dysfunction.

101 apeutic targets for diseases associated with endothelial barrier dysfunction.

102 t this KO effectively decreased heme-induced endothelial barrier dysfunction.

103 of claudin-5 mRNA and protein abundance and endothelial barrier dysfunction.

104 Endothelial barrier (EB) breaching is a frequent event d

105 keletal changes associated with S1P-mediated endothelial barrier enhancement and suggest a novel role

106 MT-actin cross talk mechanism of HGF-induced endothelial barrier enhancement and suggest that IQGAP1

107 osine 1-phosphate (S1P) produces significant endothelial barrier enhancement by means of peripheral a

108 tter understanding of mechanisms stimulating endothelial barrier enhancement may provide novel therap

109 Prostaglandin E receptor-4 receptor mediates endothelial barrier-enhancing and anti-inflammatory effe

110 This domain mediates establishment of the endothelial barrier; expression of the transmembrane dom

111 DN, while carrier-specific miRs can improve endothelial barrier formation (EV-miR-21/126) or exert a

112 nhibition both result in delayed recovery of endothelial barrier function after thrombin stimulation.

113 ofibroblast differentiation and contraction, endothelial barrier function and angiogenesis, and mesen

114 0), which is required for IGPR-1 to regulate endothelial barrier function and angiogenesis.

115 tery endothelial cells compromised pulmonary endothelial barrier function and enhanced their survival

116 e-TNF fusion product capable of altering the endothelial barrier function and improving drug penetrat

117 contributes to atherosclerosis by regulating endothelial barrier function and monocyte migration via

118 usion and blocked plasma leakage by enhanced endothelial barrier function and pericyte association wi

119 Disruption of tight junctions (TJs) perturbs endothelial barrier function and promotes inflammation.

120 R stress and O-GlcNAcylation in altering the endothelial barrier function and reveal a potential ther

121 enetrating CRADD protein (CP-CRADD) restored endothelial barrier function and suppressed the inductio

122 re, we demonstrate that CREB maintains basal endothelial barrier function and suppresses endothelial

123 conclude that AMPK activity supports normal endothelial barrier function and that LPS exposure inhib

124 injury, which is characterized by a loss of endothelial barrier function and the development of pulm

125 ver, mechanisms governing the restoration of endothelial barrier function are poorly understood.

126 A group of proteins that that control the endothelial barrier function are the RhoGTPases.

127 le-positive areas further exhibited impaired endothelial barrier function as illuminated by Evans blu

128 y, maintains AJs and mitigates disruption of endothelial barrier function by edemagenic agents, there

129 hat initiates pericyte loss and breakdown of endothelial barrier function by generating the diol 19,2

130 Regulation of brain endothelial barrier function by microRNAs in health and

131 uncover a pivotal role of CREB in regulating endothelial barrier function by restricting RhoA signali

132 Furthermore, miR-155 modulated brain endothelial barrier function by targeting not only cell-

133 However, disruption of endothelial barrier function by thrombin and histamine r

134 profoundly reduced their capacity to promote endothelial barrier function ex vivo.

135 Impaired endothelial barrier function in apolipoprotein M-deficie

136 probe in vivo mechanisms involving impaired endothelial barrier function in experimental atherothrom

137 of 62 members of the F-box protein family on endothelial barrier function in human umbilical vein end

138 at depletion of endogenous CRADD compromises endothelial barrier function in response to inflammatory

139 that gravin functionally couples to control endothelial barrier function in response to protein kina

140 ective role for the endocytic protein p18 in endothelial barrier function in settings of ALI in vitro

141 We conclude that p18 regulates pulmonary endothelial barrier function in vitro and in vivo, by en

142 We evaluated the effect of imatinib on endothelial barrier function in vitro and in vivo.

143 enoic acid from arachidonic acid, decreasing endothelial barrier function in vitro In mice in vivo ph

144 udy identifies FBXW7 as a novel regulator of endothelial barrier function in vitro.

145 Understanding endothelial barrier function is critical for vascular ho

146 Impairment of endothelial barrier function is implicated in many vascu

147 Endothelial barrier function is regulated by adherens ju

148 Endothelial barrier function is tightly regulated by pla

149 However, the role of CREB in regulating endothelial barrier function is unknown.

150 integrin activation in VE-cadherin mediated endothelial barrier function is unknown.

151 different effects of these three agonists on endothelial barrier function occur independently of Ca(2

152 ingosine-1-phosphate-mediated enhancement of endothelial barrier function occurs independently of STI

153 Impaired endothelial barrier function results in a persistent inc

154 serve to reverse vascular damage and restore endothelial barrier function through regeneration of a f

155 We show that S1P promotes cell spreading and endothelial barrier function through S1PR1-Galphai-Rac1

156 ssues is governed by mechanisms that control endothelial barrier function to maintain homeostasis.

157 Improved endothelial barrier function toward the entry of plasma

158 Endothelial barrier function was determined based on ele

159 The endothelial barrier function was evaluated by immunostai

160 Endothelial barrier function was promoted by CXCL12/CXCR

161 Endothelial barrier function was quantified by electrica

162 opography significantly influence epithelial/endothelial barrier function where increased fiber stiff

163 ibe a new assay to dynamically measure local endothelial barrier function with a lateral resolution o

164 findings and other advances in understanding endothelial barrier function with the goal of identifyin

165 odeling is associated with a local change in endothelial barrier function, a direct proof is missing

166 Endothelial barrier function, a functional correlate of

167 ight junctions with a role in maintenance of endothelial barrier function, although how this is accom

168 y maintaining arterial integrity, preserving endothelial barrier function, and a normal contractile S

169 Moreover, Bmpr2(+/-) PECs have impaired endothelial barrier function, and barrier function is re

170 nists: thrombin and histamine, which disrupt endothelial barrier function, and sphingosine-1-phosphat

171 cell coverage on the endothelium and reduced endothelial barrier function, and this effect was abroga

172 ocalcin-1 inhibits macrophages and preserves endothelial barrier function, and transgenic overexpress

173 a homotypic adhesion molecule that regulates endothelial barrier function, and transmembrane chemokin

174 stress plays a critical role in maintaining endothelial barrier function, but how this occurs remain

175 B2/EphB4 signalling is dispensable for blood endothelial barrier function, but required for stabiliza

176 for p18 in VE-cadherin trafficking and thus endothelial barrier function, in settings of ALI.

177 east as effective as SB203580 in stabilizing endothelial barrier function, reducing inflammation, and

178 gical functions, including key modulators of endothelial barrier function, regulators of gene transcr

179 ve and redundant roles in various aspects of endothelial barrier function, RhoB specifically inhibits

180 ify the contribution of the Asn-25 glycan to endothelial barrier function, we generated an N25Q mutan

181 signaling is required for receptor-regulated endothelial barrier function.

182 signaling and changes in human microvascular endothelial barrier function.

183 CR agonists that either disrupt or stabilize endothelial barrier function.

184 VE)-cadherin, resulting in the disruption of endothelial barrier function.

185 lar endothelial cells (ECs) and may regulate endothelial barrier function.

186 oted AJ integrity, and prevented the loss of endothelial barrier function.

187 tosis and thereby augmented AJ integrity and endothelial barrier function.

188 E disease severity as the result of enhanced endothelial barrier function.

189 y ecto-5'-nucleotidase (CD73) helps maintain endothelial barrier function.

190 ng molecule active in immune homeostasis and endothelial barrier function.

191 coagulation, inflammation, and disruption of endothelial barrier function.

192 Rap1-effector involved in cell spreading and endothelial barrier function.

193 ood facilitates tumor metastasis by relaxing endothelial barrier function.

194 actin dynamics, through which Rap1 modulates endothelial barrier function.

195 ion of endothelial junctions, which controls endothelial barrier function.

196 ically coordinated during cell spreading and endothelial barrier function.

197 d internal cellular tension led to decreased endothelial barrier function.

198 y strategy to prevent disruption of vascular endothelial barrier function.

199 al-cadherin cleavage and concomitant loss of endothelial barrier function.

200 s selective calcium permeation important for endothelial barrier function.

201 -time imaging, and precise quantification of endothelial barrier function.

202 tribute to vascular inflammation by altering endothelial barrier function.

203 ion molecule that regulates angiogenesis and endothelial barrier function.

204 ated receptor 1 (PAR1)-induced impairment of endothelial barrier function.

205 ich extracellular matrix stiffness regulates endothelial barrier function.

206 idual cell, indicating a local regulation of endothelial barrier function.

207 nd are recognized as essential regulators of endothelial barrier function.

208 ) BMMCs, indicating that Fn14 is crucial for endothelial barrier function.

209 creen identified FBXW7 as a key regulator of endothelial barrier function.

210 dherin at endothelial junctions and promotes endothelial barrier function.

211 and promoted both glomerular protection and endothelial barrier function.

212 bit improved adherens junction integrity and endothelial barrier function.

213 tions in endothelial morphology and impaired endothelial barrier function.

214 ion of leaky vessels and edema by regulating endothelial barrier function.

215 specific functions for Podxl in maintaining endothelial barrier function.

216 mechanism by which matrix stiffening alters endothelial barrier function.

217 d proteins, including multiple regulators of endothelial barrier functions and innate immunity.

218 othelial NP/GC-A/cGMP/PDE2 signaling impairs endothelial barrier functions.

219 erefore, enhancing drug transport across the endothelial barrier has to rely on leaky vessels arising

220 We found that endothelial barrier impairment was associated with a hig

221 on of tumor necrosis factor alpha results in endothelial barrier impairment.

222 known how this signaling pathway affects the endothelial barrier in coherent ECs forming a tight mono

223 xpression of VEGFC compromised the lymphatic endothelial barrier in mice and endothelial cells, reduc

224 tivation of TRPV4 channels regulates retinal endothelial barriers in vitro and in vivo.

225 CD4(+) T cells into the CNS and across brain endothelial barriers in vitro.

226 CXCR7 expression on endothelial barriers increased during EAE at sites of in

227 nduced TEM increase was not due to decreased endothelial barrier, increased adhesion molecule express

228 e mechanism to ensure timely transition from endothelial barrier injury to repair, accelerating barri

229 Endothelial cells have key functions in endothelial barrier integrity and in responses to angiog

230 ex partnering leading to the loss of retinal endothelial barrier integrity and increased transendothe

231 we investigated the role of free heme in the endothelial barrier integrity and mechanisms of heme-med

232 ific regulation of Rac1 trafficking controls endothelial barrier integrity during inflammation.

233 Here we report that maintenance of endothelial barrier integrity during leukocyte diapedesi

234 the endothelial cell surface, and decreased endothelial barrier integrity in vitro, therefore increa

235 Endothelial barrier integrity is required for maintainin

236 ependent manner, induced a rapid drop in the endothelial barrier integrity of HLMVECs.

237 ata indicate that matrix stiffness regulates endothelial barrier integrity through FAK activity, prov

238 CNS autoimmunity, the consequences on brain endothelial barrier integrity upon interaction with such

239 findings demonstrate that HIF2alpha enhances endothelial barrier integrity, in part through VE-PTP ex

240 NA-mediated down-regulation of Lyn disrupted endothelial barrier integrity, whereas expression of a c

241 orectal tumors in mice and reduces lymphatic endothelial barrier integrity.

242 hanisms and its role in maintaining vascular endothelial barrier integrity.

243 Prnd(-/-) mice also displayed defects in endothelial barrier integrity.

244 K plays a critical role in the regulation of endothelial barrier integrity.

245 whereas other blood cells readily cross the endothelial barrier into the circulation.

246 conjugation facilitates ASO transport across endothelial barriers into tissue interstitium.

247 During metastasis, breakdown of the endothelial barrier is critical for tumor cell extravasa

248 how histamine induces the disruption of the endothelial barrier is not well defined.

249 Permeability of the endothelial barrier is primarily regulated by a protein

250 ics activating Lyn kinase may strengthen the endothelial barrier junction and hence have anti-inflamm

251 ing a cross-talk between fibroblasts and the endothelial barrier leading to barrier opening, cellular

252 ewly defined signaling pathways that mediate endothelial barrier leakiness (hyperpermeability) that a

253 We observed that lung endothelial barrier leakiness and edema induced by raisi

254 The endothelial barrier maintains vascular and tissue homeos

255 targeting neutrophil diapedesis through the endothelial barrier may represent a new therapeutic aven

256 tight- and adherens-junction proteins in the endothelial barrier of the stria vascularis (intrastrial

257 165 nor VEGF165b significantly altered brain endothelial barrier or angiogenesis in vitro.

258 in-1 with a claudin-1 peptide improves brain endothelial barrier permeability and consequently functi

259 with a specific C1C2 peptide improved brain endothelial barrier permeability and functional recovery

260 o failed to protect against thrombin-induced endothelial barrier permeability in cells deficient in b

261 ide (LPS)-induced inflammatory responses and endothelial barrier permeability in human primary pulmon

262 38 activation was critical for PAR1-promoted endothelial barrier permeability in vitro, and p38 signa

263 l (VE)-cadherin homophilic adhesion controls endothelial barrier permeability through assembly of adh

264 metabolite of arachidonic acid (AA), induced endothelial barrier permeability via Src and Pyk2-depend

265 In vivo, Pi16 (-/-) mice show reduced endothelial barrier permeability, lower leukocyte infilt

266 EPCR), a protein involved in coagulation and endothelial barrier permeability.

267 nist-induced phosphoinositide hydrolysis and endothelial barrier permeability.

268 ncreased F-actin stress fibers and increased endothelial barrier permeability.

269 r p38 activation used by PAR1 that regulates endothelial barrier permeability.

270 nterendothelial junction (IEJ), causes acute endothelial barrier permeability.

271 ascorbate in the prevention of inflammatory endothelial barrier permeabilization and explain the und

272 g RNA attenuated the HGF-induced increase in endothelial barrier properties and abolished HGF-activat

273 pendent kinase I (cGKI), strengthen systemic endothelial barrier properties in acute inflammation.

274 n of tight junction (TJ) gene expression and endothelial barrier properties.

275 -2, which is critical for Rac1 signaling and endothelial barrier protection but not for thrombin-indu

276 ed C3 botulinum toxin substrate 1 (Rac1) and endothelial barrier protection.

277 Endothelial barrier protective effects of activated prot

278 We also tested the hypothesis that an endothelial barrier-protective bioactive lipid, sphingos

279 t those beginning at amino acid 39, conveyed endothelial barrier-protective effects.

280 observations have important implications for endothelial barrier regulation in glomerular and other m

281 improve our understanding on human pulmonary endothelial barrier regulation.

282 up-regulation of Rac signaling critical for endothelial barrier regulation.

283 e infiltration and reduced activation of the endothelial barrier regulator MLCK, and reduced phosphor

284 Platelet intoxication prevents endothelial barrier repair and facilitates formation of

285 Repair of a dysfunctional endothelial barrier requires controlled restoration of a

286 r translocation (~15%) across the co-culture endothelial barrier resulting in regression of tumor in

287 tricts tumor cell extravasation by enhancing endothelial barrier stability through modulation of mole

288 tial hits, of which, four compounds enhanced endothelial barrier stability while concurrently suppres

289 VIIIa; (2) a cytoprotective on the basis of endothelial barrier stabilization and anti-inflammatory

290 nti-inflammatory responses, prosurvival, and endothelial barrier stabilization.

291 afficking to facilitate dissemination across endothelial barriers such as the blood-brain barrier.

292 esenting a novel target for preventing leaky endothelial barrier syndrome.

293 that it is neutrophil diapedesis through the endothelial barrier that is responsible for the bleeding

294 cytes contribute to cellular interactions at endothelial barriers that impart protective CNS inflamma

295 bioenergetics and failure of epithelial and endothelial barriers that produce organ dysfunction and

296 adherin homophilic interaction in modulating endothelial barrier through the tuning of MT dynamics.

297 ium prepared from the stressed OPCs weakened endothelial barrier tightness in vitro.

298 An example is drug carriers targeted to endothelial barriers, which can be transported to intra-

299 er demonstrate a protective role for TNAP at endothelial barriers within this axis, transgenic mice w

300 vascular endothelial cAMP and stabilize the endothelial barrier would attenuate the action of endoge