ライフサイエンスコーパス: endothelin

1 sociated with reduced expression of vascular endothelin.

2 ects of another GWAS signal were mediated by endothelin.

3 (LPA; acting through the LPA1 receptor) and endothelin.

4 orsal Jag1 expression but also by inhibiting endothelin 1 (Edn1) expression in the pharyngeal endoder

5 perturbations demonstrates complex roles for Endothelin 1 (Edn1) signaling in the intermediate joint-

6 emonstrate rs9349379 regulates expression of endothelin 1 (EDN1), a gene located 600 kb upstream of P

7 etermine the selective affinity of EDNRA for endothelin 1 (EDN1), its major physiological ligand, and

8 ular density) and the potent vasoconstrictor endothelin 1 (EDN1); we assayed the activity of angioten

9 Endothelin 1 (ET-1) and ET-2 activate two G protein-coup

10 Endothelin 1 (ET-1), mainly produced from vascular endot

11 mpaired vasodilator reactivity and increased endothelin 1 (ET-1)-mediated vasoconstriction, two abnor

12 eased expression of vasoconstrictor molecule endothelin 1 and a concomitant decrease in vasodilatory

13 scription by Dot1a and HDAC2, and reinforces endothelin 1 as a therapeutic target of kidney fibrosis.

14 lly polarized molecular landscape identified endothelin 1 as an important secreted regulator of human

15 tic effect by repressing Edn1, which encodes endothelin 1 in the connecting tubule/collecting duct.

16 e complement anaphylatoxins C3a and C5a, and endothelin 1, induced human MCs rapidly to secrete small

17 atory BP), arterial stiffness, nitric oxide, endothelin 1, or blood lipid profile.

18 resence of an endothelin-converting enzyme 1/endothelin 1-SphK positive feedback loop.

19 er quartile); pulmonary hypertension and low endothelin-1 <1.7 pg/mL; lower 3 quartiles); no pulmonar

20 ould be explained by an enhanced response to endothelin-1 (20% greater reduction in lumen diameter, P

21 locus acting as a potential enhancer for the endothelin-1 (EDN1) gene.

22 d cardiovascular progenitors using WNT3A and endothelin-1 (EDN1) human recombinant proteins.

23 s the secretion of a potent vasoconstrictor, endothelin-1 (EDN1), which continues to increase as the

24 (Ednra) expression and increased circulating endothelin-1 (Edn1).

25 NGF, miR-98, PPARgamma, fibronectin 1 (FN1), endothelin-1 (EDN1, herein referred to as ET-1), and col

26 oxygen species, which evoked the release of endothelin-1 (ET) that activated pericyte ET(A) receptor

27 teral striatal injection of vasoconstrictive endothelin-1 (ET-1) along with Abeta toxicity on CNS pat

28 newborn arteries also expresses and releases endothelin-1 (ET-1) and initiates endothelium-dependent

29 Endothelin-1 (ET-1) antagonists are a possibility becaus

30 Gene profiling identified inter alia endothelin-1 (ET-1) as one of the target genes of P2Y4 i

31 Previous studies suggest that endothelin-1 (ET-1) contributes to the pathogenesis of E

32 Endothelin-1 (ET-1) dose and time-dependently up-regulat

33 (NGAL), kidney injury molecule-1 (KIM-1) and endothelin-1 (ET-1) during EVKP in a series of discarded

34 Endothelial expression and the release of endothelin-1 (ET-1) in levels sufficient to initiate vas

35 Endothelin-1 (ET-1) is a potent endothelial-derived vaso

36 The vasoconstrictor peptide endothelin-1 (ET-1) is a transcriptional target of TGF-b

37 Endothelin-1 (ET-1) is a vasoactive peptide that is elev

38 Endothelin-1 (ET-1) is an indicator of endothelial injur

39 Since endothelin-1 (ET-1) is implicated in blood pressure (BP)

40 ceptor mediating the vasodilatory effects of endothelin-1 (ET-1) is induced by OA-NO2 Inasmuch as ET-

41 Endothelin-1 (ET-1) is involved in the pathogenesis of c

42 rum concentrations of the vasoactive protein endothelin-1 (ET-1) occur in the setting of systemic inf

43 The present study investigated the effect of endothelin-1 (ET-1) on cholinergic mechanisms of end-org

44 y increasing nitric oxide and downregulating endothelin-1 (ET-1) production, has been implicated in I

45 Endothelin-1 (ET-1) promotes renal damage during cardiov

46 s including angiotensin II, aldosterone, and endothelin-1 (ET-1) that mediate the immediate benefit o

47 increased expression of the vasoconstrictor endothelin-1 (ET-1) within PASMCs.

48 Here, we report that Endothelin-1 (ET-1), a molecular component of the postna

49 ) correlated with increased plasma levels of endothelin-1 (ET-1), a potent vasoconstrictor, in sickle

50 xpression of the endothelin axis components [endothelin-1 (ET-1), endothelin-3 (ET-3), endothelin rec

51 Vasoconstrictors, including endothelin-1 (ET-1), inhibit myocyte BK channels, leadin

52 trictions of venules from euglycemic pigs to endothelin-1 (ET-1), thromboxane analog U46619, and nore

53 Endothelin-1 (ET1) synthesis is understood to promote ca

54 We hypothesized that endothelin-1 (ET1), a secreted paracrine factor of ECs,

55 ubgroup with pulmonary hypertension and high endothelin-1 (high endothelin-1: >/=1.7 pg/mL; upper qua

56 lin-1; and no pulmonary hypertension and low endothelin-1 (log-rank chi2 = 77.16; P < .01 ).

57 these proteins in DN, and demonstrated that endothelin-1 activates podocytes to release heparanase.

58 Endothelin-1 activates the phospholipase C pathway, lead

59 The endothelial specific mediator endothelin-1 along with interleukin (IL)-6, IL-8, tumor

60 of ARHGAP18 resulted in a failure to secrete endothelin-1 and a reduction in neutrophil transmigratio

61 (OPN) in mouse arteries via local release of endothelin-1 and activation of CREB.

62 y PGP levels associate with both circulating endothelin-1 and acute rejection in cardiac transplant p

63 nterleukin-6 and osteopontin, lowered plasma endothelin-1 and blood pressure, and improved mouse surv

64 eraction with GRK2 is inversely regulated by endothelin-1 and CAV1 scaffolding domain after liver inj

65 lacylcarnitines correlated with increases in endothelin-1 and creatinine/cystatin C, respectively.

66 -beta1 signaling and increased expression of endothelin-1 and genes involved in VSMC contraction, hig

67 However, endothelin-1 and IL-6 increased, and IL-10 decreased, be

68 ibited lower oxidative stress, expression of endothelin-1 and monocyte chemoattractant protein-1, and

69 Plasma endothelin-1 and OPN concentrations are positively corre

70 Despite pathophysiological links between endothelin-1 and pulmonary vascular remodeling, to our k

71 e previously showed that both heparanase and endothelin-1 are essential for the development of DN.

72 es of evidence have demonstrated the role of endothelin-1 as both a constrictor of uterine myometrial

73 In injured SECs, endothelin-1 blocked CAV1 phosphorylation induced by CAV

74 y in systemic sclerosis after macitentan, an endothelin-1 blocker.

75 emokine Receptor 2 (CXCR2) and production of endothelin-1 both in vitro and in vivo.

76 a) and the neuroendocrine regulatory peptide endothelin-1 by DH82 cells.

77 fumigatus specifically caused production of endothelin-1 by epithelial cells in vitro but not any of

78 Also, whether endothelin-1 can predict future heart failure and mortal

79 lymphopoietin-induced Ca(2+)-influx, whereas endothelin-1 caused itch-selective B-type natriuretic pe

80 tic peptide), and cGMP, and decreased plasma endothelin-1 compared with PH alone.

81 TGFbeta1 signaling via type I receptors and endothelin-1 contribute to mesenchymal lineage transitio

82 Endothelin-1 differentially directs lineage specificatio

83 ist, we demonstrated for the first time that endothelin-1 drives many features of airway remodelling

84 GFR, plasma renin concentration, and urinary endothelin-1 excretion were similar between knockout and

85 Mediation analysis showed that BNP and endothelin-1 explained 56% and 40%, respectively, of the

86 = 0.0009) expression, with no differences in endothelin-1 expression.

87 EndMT, suppression of eNOS, and induction of endothelin-1 expression.

88 fibroblasts were treated with 20 and 100 nM endothelin-1 for 6 and 24 hours and then collected to as

89 dney vasculature and normalized Tgf-beta and endothelin-1 gene expression in aged MWF rats.

90 array analysis showed increased Tgf-beta and endothelin-1 gene expression with age.

91 generated low-expressing and high-expressing endothelin-1 genes (L and H) and have bred mice with fou

92 A fumigatus also induced endothelin-1 in murine lungs, associated with extensive

93 Accordingly, VAMP3 co-occurred with endothelin-1 in the skins of patients with AD.

94 the expression of contractile markers and of endothelin-1 in VSMCs.

95 s not known whether elevated serum levels of endothelin-1 indicate future risk of kidney disease in t

96 s on d1, d7, and d28 post Abeta toxicity and endothelin-1 induced ischemia (ET1) in rats.

97 Specifically, endothelin-1 induces sympathetic neurons expressing the

98 Vasoconstriction blockade with the endothelin-1 inhibitor BQ-123, or ROS scavenging after S

99 We conclude that endothelin-1 is critical for maintaining normal contract

100 0.05), but not in vascular endothelial cell endothelin-1 knockout (VEET KO) mice (76.4 +/- 5.7 pg/mg

101 ular risk in black adults, we measured serum endothelin-1 level at baseline (2000-2004; n=3538).

102 Phenotyping by pulmonary hypertension and endothelin-1 level showed mortality decreasing in order

103 Log-transformed plasma endothelin-1 level.

104 ur knowledge, the association between plasma endothelin-1 levels and pulmonary hypertension has not b

105 ied African American individuals with plasma endothelin-1 levels and tricuspid regurgitation on echoc

106 In conclusion, higher baseline serum endothelin-1 levels associated with incident CKD and all

107 consistent with the hypothesis that elevated endothelin-1 levels contribute to subepithelial thickeni

108 Participants with baseline endothelin-1 levels in higher quartiles had a greater in

109 Mean (SD) endothelin-1 levels were 1.36 (0.64) pg/mL; 217 of 3223

110 g for potential confounders, log-transformed endothelin-1 levels were associated with increased odds

111 Log-transformed endothelin-1 levels were associated with mortality (adju

112 Mechanistically, increased endothelin-1 levels were detected in TGFbetaRII-KO endot

113 Endothelin-1 levels were significantly increased 20 hr a

114 Elevated plasma endothelin-1 levels, especially associated with an eleva

115 tion of the endothelin-A receptor (EDNRA) by endothelin-1 may play a role in the disease because the

116 antinociceptive effect through inhibition of endothelin-1 mediated neuronal activation, revealing the

117 specimens and plasma of CTEPH patients, and endothelin-1 overexpression was prevented by inhibition

118 rease in eNOS expression, and an increase in endothelin-1 plasma levels, with all mice dying within 5

119 Endothelin-1 positively associated with all-cause mortal

120 Endothelin-1 promotes vasculopathy in systemic sclerosis

121 Using a selective endothelin-1 receptor antagonist, we demonstrated for th

122 ion was associated with increased glomerular endothelin-1 receptor type A (Ednra) expression and incr

123 esting that p66Shc expression did not affect endothelin-1 release from resident endothelial cells.

124 Acute application of endothelin-1 revealed significantly elevated production

125 Of these, the vasoconstrictive factor endothelin-1 serves as an integral point of communicatio

126 Our data suggest that in diabetes, endothelin-1 signaling, as occurs in endothelial activat

127 Endothelin-1 stimulated the production of MMP1, MMP8, an

128 cell Abs-angiotensin type 1 receptor (AT1R), endothelin-1 type A and natural polyreactive Abs-did not

129 anti-angiotensin II type-1 receptor and anti-endothelin-1 type A receptor autoantibodies are associat

130 tatus for angiotensin II type-1 receptor and endothelin-1 type A receptor autoantibodies pre-LT, and

131 PKG) activity independently of diet, whereas endothelin-1 was increased by diet and Abeta42.

132 The extracellular concentration of endothelin-1 was increased following GLO1-knockdown, whe

133 illations triggered by endogenously released endothelin-1 were recorded in smooth muscle cells of the

134 The levels of ET-1(endothelin-1) and Ang II (Angiotensin II) in the plasma

135 levels of the vasoconstrictor peptide ET-1 (endothelin-1) and higher levels of the 2 potent vasodila

136 ious pruritogens (histamine, chloroquine, or endothelin-1) and recorded spontaneous scratching before

137 to histaminergic (histamine, compound 48/80, endothelin-1), not non-histaminergic (chloroquine) pruri

138 ure to vasoconstrictors (50 mM KCl and 20 nM Endothelin-1).

139 creased production of vasoconstrictors (e.g. endothelin-1).

140 (adjusted hazard ratio per log increment in endothelin-1, 1.57, 95% CI, 1.05-2.37; median follow-up,

141 on (adjusted odds ratio per log increment in endothelin-1, 1.66; 95% CI, 1.16-2.37).

142 (adjusted hazard ratio per log increment in endothelin-1, 1.69; 95% CI, 1.27-2.25; median follow-up,

143 Endothelin-1, a marker of endothelial dysfunction, is a

144 Endothelin-1, a very potent vasoconstrictor, is a key mo

145 We assessed the role of endothelin-1, acting through endothelin A (ET(A) ) recep

146 uremic toxins (i.e., uric acid, phosphates, endothelin-1, advanced glycation end-products, and asymm

147 (ICAM-1), anti-LG3, aminopeptidase N, CXCL9, endothelin-1, and gelsolin.

148 ated cytokines thymic stromal lymphopoietin, endothelin-1, and inflammatory tumor necrosis factor-alp

149 transforming growth factor beta1 (TGFbeta1), endothelin-1, and NAD(P)H oxidase 4 also occur in parall

150 k involving transforming growth factor-beta, endothelin-1, angiotensin II, CCN2 (connective tissue gr

151 ate that BMP9 can affect the balance between endothelin-1, apelin, and adrenomedullin.

152 factors, TGF-beta1, TGF-beta2, periostin and endothelin-1, by human airway epithelial cells and in mi

153 procalcitonin, MR-pro-adrenomedullin, CT-pro-endothelin-1, CT-pro-arginine vasopressin, and MR-pro-at

154 hic acid I, calcitonin gene-related peptide, endothelin-1, gentamicin, norepinephrine and vasopressin

155 othelin-1; (d) immunohistochemistry of eNOS, endothelin-1, P-selectin, intercellular adhesion molecul

156 with elevated vasoconstrictor signalling via endothelin-1, reduces the local vasodilatory response to

157 activated gene networks involved in calcium, endothelin-1, renin-angiotensin, and cardiac beta-adrene

158 cterised by the measurement of nitric oxide, endothelin-1, tissue plasminogen activator and plasminog

159 s elicited by phenylephrine, angiotensin II, endothelin-1, U46619, and K(+)-induced membrane depolari

160 es was increased expression and secretion of endothelin-1, which is also a known pruritogen.

161 In vitro, endothelin-1- and, in vivo, pressure overload-induced ca

162 The endothelin-1-induced vasodilation in these PCOS subject,

163 zed mesenteric arteries pre-constricted with endothelin-1.

164 cluding BNP (B-type natriuretic peptide) and endothelin-1.

165 t in the eNOS/cGMP/PKG pathway and decreased endothelin-1.

166 e including thymic stromal lymphopoietin and endothelin-1.

167 els mediate their spontaneous motion via the endothelin-1/endothelin receptor A pathway.

168 ary hypertension and high endothelin-1 (high endothelin-1: >/=1.7 pg/mL; upper quartile); pulmonary h

169 endothelial nitric oxide synthase (eNOS) and endothelin-1; (d) immunohistochemistry of eNOS, endothel

170 artiles); no pulmonary hypertension and high endothelin-1; and no pulmonary hypertension and low endo

171 ise in the expression of the vasoconstrictor endothelin 2 by follicle cells of wild-type mice.

172 e mice, infusion of vasoconstrictors (either endothelin 2 or angiotensin 2) into the bursa restored t

173 Although increasing evidence indicates that endothelin-2 (Edn2) has distinct roles in tissue patholo

174 Endothelin-2 (EDN2) is a potent vasoconstrictor that is

175 in white mutants a transcriptional defect in endothelin 3 (edn3), encoding a peptide factor that prom

176 d by molecules such as the signaling protein endothelin 3 (EDN3), its receptor (the endothelin recept

177 thelin axis components [endothelin-1 (ET-1), endothelin-3 (ET-3), endothelin receptor A (EdnrA), Ednr

178 comprehensive panel of pruritogens (C48/80, endothelin, 5-HT, chloroquine, histamine, lysophosphatid

179 sed the role of endothelin-1, acting through endothelin A (ET(A) ) receptors, in modulating the centr

180 in axis, which is a pathway comprised of the endothelin A and B receptors (ET(A)R and ET(B)R).

181 Mechanistically, endothelin A receptor (ETAR)-positive macrophages are hi

182 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albu

183 Atrasentan, a selective endothelin A receptor antagonist, has been shown to redu

184 ion of similar magnitude (P </= 0.05) of the endothelin A receptor in the lung tissue.

185 dothelin signaling via the activation of the endothelin-A receptor (EDNRA) by endothelin-1 may play a

186 o three groups: placebo (RVD+PTRAS), chronic endothelin-A receptor (ET-A) blockade (RVD+PTRAS+ET-A),

187 g-term treatment strategy with the selective endothelin-A receptor (ETA) antagonist, ambrisentan, des

188 pressure, augmentation index, blood glucose, endothelin, adhesion molecules, or clotting factors in t

189 ggered by two keratinocyte-secreted factors, endothelin and acetylcholine, which acted via specific m

190 While targeting endothelin and angiotensin, which are upstream regulator

191 indicating that Six1 and Six2 regulate both endothelin and bone morphogenetic protein-4 signaling pa

192 factor, vascular endothelial growth factor), endothelin and inhibitors of chemotaxis.

193 n various mediators, including nitric oxide, endothelin, and prostanoids, among others.

194 oncentration of catecholamines, vasopressin, endothelin, and renin activity in 14 patients with CIPA,

195 The endothelin axis and in particular the two endothelin rec

196 We found endothelin axis component (EdnrA, EdnrB, ET-1, ET-3) exp

197 Expression of the endothelin axis components [endothelin-1 (ET-1), endothe

198 genes of the pathway, demonstrating that the endothelin axis genes are methylated and dysregulated in

199 er metastasis and pain are controlled by the endothelin axis, which is a pathway comprised of the end

200 The endothelin B receptor (ET(B) R) subtype mediates vasodil

201 to a cysteine sulfenic acid modification in endothelin B receptor and consequently decreased endothe

202 BR-4628 against IR was lost when a selective endothelin B receptor antagonist was coadministered.

203 We have demonstrated cerebral endothelin B receptors (ETBR) as a potential target to t

204 Endothelin-B receptor agonist, IRL-1620, provides signif

205 The endothelins comprise three structurally similar peptides

206 a nicotinic receptor (CHRNG, 6 subjects) and endothelin converting enzyme-like 1 (ECEL1, 4 subjects).

207 Metalloproteases, including endothelin-converting enzyme (ECE)-1 and -2, reside with

208 nists (BQ123 plus BQ788) or by inhibition of endothelin-converting enzyme (phosphoramidon or SM19712)

209 empty spiracles homeobox 1 [EMX1], AK055957, endothelin-converting enzyme 1 [ECE1], phosphofructokina

210 -1 expression, indicating the presence of an endothelin-converting enzyme 1/endothelin 1-SphK positiv

211 t inhibition of SphK leads to suppression of endothelin-converting enzyme-1 expression, indicating th

212 We further identify the endothelin/Ednra pathway as an autocrine activator of Gq

213 receptors (GPCRs), including adrenergic and endothelin (ET) receptors, after elevated neurohormonal

214 While endothelin (ET)-1 plays a role in regulating blood flow

215 layed a vasoconstriction response to KCl and endothelin for each experimental group.

216 osis factor-alpha, IL-1b, troponin, vascular endothelin growth factor, IL-17a, matrix metallopeptidas

217 Endothelin-induced vasoconstriction by hepatic stellate

218 C-dependent, positive-feedback mechanism for Endothelin induction and establish MEF2C as an immediate

219 est enhancer from the mouse genome abolishes Endothelin induction of Mef2c expression.

220 dies have identified important roles for the endothelin isoforms and new therapeutic targets during d

221 ity associated with experience by regulating endothelin levels, which in turn affect the myelinating

222 Endothelin ligands (Edns) and endothelin receptors (Ednr

223 alyzed the expression of the complete set of endothelin ligands and receptors in the jawless vertebra

224 S/MS to identify NT-proET-1 (ppET-1[18-50]), Endothelin-Like Domain Peptide (ELDP, ppET-1[93-166]) an

225 ELDP contains the evolutionary conserved endothelin-like domain sequence, which potentially confe

226 Further, normal Wnt and Endothelin niche signals during hair anagen onset are hi

227 In the absence of endothelin or plexin signaling, sympathetic neurons misp

228 pressure, augmentation index, blood glucose, endothelin, proprotein convertase subtilisin/kexin type

229 y by Jagged-Notch signaling and ventrally by endothelin receptor A (EDNRA) signaling.

230 s [endothelin-1 (ET-1), endothelin-3 (ET-3), endothelin receptor A (EdnrA), EdnrB] were determined ov

231 reast cancer cells through interference with endothelin receptor A (ETA).

232 Endothelin receptor A and p66Shc regulate spontaneous Ca

233 ontaining structural analogs of the marketed endothelin receptor A antagonist Ambrisentan, were ident

234 Endothelin receptor A antagonist BQ123 dramatically redu

235 Conditional loss of endothelin receptor A in granulosa cells also decreased

236 heir spontaneous motion via the endothelin-1/endothelin receptor A pathway.

237 show that zebrafish harbouring a mutation in endothelin receptor aa (ednraa) form less cohesive shoal

238 In many studies, such as the Study with an Endothelin Receptor Antagonist in Pulmonary Arterial Hyp

239 The endothelin receptor antagonist is among the most effecti

240 The endothelin receptor antagonist macitentan has demonstrat

241 us epoprostenol were weaned off post-LT, and endothelin receptor antagonist or phosphodiesterase type

242 Endothelin receptor antagonists (ERA) and phosphodiester

243 Endothelin receptor antagonists have emerged as a novel

244 Endothelin receptor antagonists have revolutionized the

245 data support a potential role for selective endothelin receptor antagonists in protecting renal func

246 Additionally, infusion of endothelin receptor antagonists into the bursa of wild-t

247 were receiving riociguat in combination with endothelin receptor antagonists or prostanoids, or both.

248 ials continue to explore new applications of endothelin receptor antagonists, particularly in treatme

249 erent classes of drugs are now available-ie, endothelin receptor antagonists, phosphodiesterase-5 inh

250 ts, which have been previously attributed to endothelin receptor antagonists, were more frequent in t

251 se biological effects that are unaffected by endothelin receptor antagonists.

252 terase type 5 inhibitors, sodium nitrite and endothelin receptor antagonists.

253 ALK5 inhibition and endothelin receptor antagonization inhibited mesenchymal

254 Animal models of endothelin receptor B (EdnrB) mutation reliably model hu

255 We observed that endothelin receptor B [ET-B (gene name EDNRB)], the rece

256 lling through the G protein-coupled receptor endothelin receptor B and PKC epsilon, regulates the num

257 in the neural crest-conditional deletion of endothelin receptor B model of Hirschsprung-associated e

258 ts may constitute the mechanism of action of endothelin receptor blockers in DN.

259 scular endothelial nitric oxide synthase and endothelin receptor expression and impaired exercise tol

260 Furthermore, depletion of EDN1 or the use of endothelin receptor inhibitors bosentan and ambrisentan

261 In mice, podocyte-specific knockout of the endothelin receptor prevented the diabetes-induced incre

262 The endothelin receptor type A (EDNRA) signaling pathway is

263 2 activate two G protein-coupled receptors - endothelin receptor type A (ET(A)) and endothelin recept

264 ogenesis of BMSCs was attenuated by blocking endothelin receptor type A (ETAR) and/or endothelin rece

265 ors - endothelin receptor type A (ET(A)) and endothelin receptor type B (ET(B)) - with equal affinity

266 These cells highly expressed endothelin receptor type B (ETB(R)) and Jagged1, a Notch

267 The endothelin receptor type B (ETBR) regulates water and el

268 ing endothelin receptor type A (ETAR) and/or endothelin receptor type B (ETBR).

269 otein endothelin 3 (EDN3), its receptor (the endothelin receptor type B [EDNRB]), and the transcripti

270 genome sequencing, we discovered that EDNRB (Endothelin receptor type B) is a candidate gene involved

271 Endothelin-receptor antagonists are in clinical use to t

272 Endothelin ligands (Edns) and endothelin receptors (Ednrs) are unique to vertebrates(3

273 of diabetes, include use of drugs that block endothelin receptors (eg, atrasentan) and non-steroidal

274 Endothelin receptors are also expressed on the human ecc

275 he endothelin axis and in particular the two endothelin receptors, ETA and ETB, are targets for thera

276 bofibrosis, which were prevented by blocking endothelin receptors.

277 We show that Endothelin signaling activates Mef2c expression in the n

278 These data suggest that OA-NO2 modulates endothelin signaling by increasing Nrf2-dependent expres

279 duplication and specialization of vertebrate Endothelin signaling coincided with the appearance of hi

280 ednr expression, we also analyzed all known Endothelin signaling components in the African clawed fr

281 To test the potential role of endothelin signaling diversification in the evolution of

282 nscriptional effectors directly activated by Endothelin signaling during neural crest development rem

283 amine in more detail the effect of OA-NO2 on endothelin signaling in human endothelial cells.

284 tream transcriptional target and effector of Endothelin signaling in the neural crest.

285 diate transcriptional effector and target of Endothelin signaling in the neural crest.

286 Endothelin signaling in turn induces expression of the r

287 In jawed vertebrates, Endothelin signaling involves multiple functionally dist

288 r neural crest development, and dysregulated Endothelin signaling is associated with several neural c

289 Endothelin signaling is essential for neural crest devel

290 Endothelin signaling regulates several aspects of NCC de

291 Endothelin signaling via the activation of the endotheli

292 Additionally, we show that increasing endothelin signalling rescues this myelination defect ca

293 Here we define a pathway in which endothelin, signalling through the G protein-coupled rec

294 acrine and autocrine factors, especially the endothelin system, are regulated by clock genes.

295 FRET-based biosensors, we show that LPA and endothelin transiently activate Cdc42 through Gi, concur

296 veral studies reported a central role of the endothelin type A receptor (ETAR) in tumor progression l

297 es to angiotensin type 1 receptor (AT1R) and endothelin type A receptor (ETAR) is associated with all

298 s significantly increased by blockade of the endothelin type A receptor with ABT-627 (0.116 +/- 0.006

299 ge factor 6, angiotensin-II type 1 receptor, endothelin type A receptor, lamin B1, BPI fold-containin

300 scular endothelial nitric oxide synthase and endothelin was assessed in lung tissue to determine diff