ライフサイエンスコーパス: engagement

1 of close friends, volunteering, and cultural engagement).

2 s during the subsequent 2 weeks of treatment engagement.

3 s involving simultaneous motor and cognitive engagement.

4 TACs drive degradation primarily by covalent engagement.

5 wed by membrane curvature and distal leaflet engagement.

6 are predominately global and related to task engagement.

7 ibly reflecting an enhanced drive for social engagement.

8 these are the sole determinants for caspase engagement.

9 eIF5A/Tsc2 mRNA complexes for translational engagement.

10 olicies and increase community awareness and engagement.

11 d involvement for Rap1 in novelty-driven PFC engagement.

12 , and increased HCV prevention and treatment engagement.

13 zation reflects global arousal, such as task engagement.

14 a and to assess how adherence affects reader engagement.

15 -free care environment is essential for care engagement.

16 limited in part by their irreversible target engagement.

17 substrate due to their mutual sliding after engagement.

18 establish a new ecosystem for science public engagement.

19 us, demonstrating relebactam-Bla(Mab) target engagement.

20 ell as the likely timing of their pathogenic engagement.

21 NA leakage into the cytosol and chronic cGAS engagement.

22 in the 3DM and MR groups reported increased engagement.

23 stakeholders in sustainability planning and engagement.

24 ments alongside an enhanced drive for social engagement.

25 from the cleft and directly impacted KIR3DL1 engagement.

26 nual telephone reminder for reevaluation and engagement.

27 ance and an improved understanding of target engagement.

28 ut also support publisher goals of reach and engagement.

29 artner and later in the 30 minutes of social engagement.

30 wed evidence of symptom reduction and target engagement.

31 ity in multidisciplinary research and public engagement.

32 ells in terms of immunomodulation after TLR3 engagement.

33 omplex behaviours that also required patient engagement.

34 h tonic or sustained signalling after ligand engagement.

35 liability, generalizability, and participant engagement.

36 actice have been shaped by multidisciplinary engagements.

37 scytosis of IgGs with native or reduced FcRn engagement across human induced pluripotent stem cell-de

38 We aimed to assess PrEP uptake and engagement after population-level HIV testing and univer

39 access to experts; deeper and broader human engagement among colleagues, collaborators, and competit

40 This demonstrates that selective engagement and activation of FZD7 signaling is sufficien

41 n which new drugs could be tested for target engagement and anti-tumor efficacy.

42 d was partially dependent on T cell receptor engagement and commensal-derived signals.

43 in BAF complex architecture upon nucleosome engagement and compare the structural model of endogenou

44 ibrium and real-time analyses of GPCR ligand engagement and consequent activation, measured as recept

45 Here, we review the engagement and effects of gain modulation in the cortex.

46 ons affect kinase conformations and thus the engagement and efficacy of V600E-specific BRAF inhibitor

47 The intervention comprised community engagement and existing community health worker-led mobi

48 that TPP enables organ-specific drug target engagement and identification studies during the later s

49 However, surgeon engagement and optimal video duration remain undefined.

50 M6620 was well tolerated, with target engagement and preliminary antitumor responses observed.

51 Although activating receptor engagement and proinflammatory cytokines are required to

52 e anticipate that this combination of target engagement and proximal functional readout will prove us

53 o differences in clinical care and a lack of engagement and recruitment of under-represented populati

54 Molecular analyses confirmed target engagement and reduced oxidative stress, unfolded protei

55 Furthermore, we demonstrate in vivo target engagement and reduction of tumor burden in three mouse

56 y of immune responses mediated upon FcgammaR engagement and review the available experimental evidenc

57 assessment of the clinical impact of target engagement and serves as a model for implementing the 'f

58 s was consistent with a decrease in FcgammaR engagement and subsequent ADCC effector function, as the

59 AMPH typically increases task engagement and the effort animals exert for reward, desp

60 izational membership, volunteering, cultural engagement), and economic factors (wealth, income), at b

61 sleep, media, diet), social (e.g., support, engagement), and environmental (e.g., green space, pollu

62 refractory toward small-molecule therapeutic engagement, and additional therapeutic modalities are ne

63 ge response, intracellular signaling, immune engagement, and genetic alterations characteristic of fa

64 ons (ie, HIV prevention, testing, treatment, engagement, and re-engagement) to identify combination s

65 clinical species, with strong in vivo target engagement, and should robustly inhibit glutaminase in h

66 n include multilevel approaches, stakeholder engagement, and sustainability.

67 ivity against related proteases, good target engagement, and tryptase inhibition in HMC1 xenograft mo

68 ns can be used to accurately quantify viewer engagement; and (3) examine whether blink rate patterns

69 and sharing; (3) legal issues; (4) community engagement; and (5) communication and dissemination.

70 cision aids; screening checklists; community engagement; and provider training.

71 The binding affinity and kinetics of target engagement are fundamental to establishing structure-act

72 comes clear that practices such as community engagement are needed to address the important social im

73 ease Control and Prevention define community engagement as "the process of working collaboratively wi

74 d in salience detection, attention, and task engagement as a function of increasing target SES.

75 -income countries and the importance of Gavi engagement as early as possible in product development p

76 Target engagement assays are crucial for establishing the mecha

77 inx immigrant communities requires community engagement, assurance of confidentiality, and creative r

78 se-based reporter assays demonstrated target engagement at low nM concentrations, and molecular assay

79 Delicate and transitory protein engagement at the plasma membrane (PM) is crucial to a b

80 ssessed views, geographic location, audience engagement (average percent of video watched), audience

81 We advocate for increased engagement between ecology and infectious researchers to

82 we uncover evolutionarily conserved rules of engagement between RNA helicases and tripartite motif (T

83 evoked potential suppression the key target engagement biomarker.

84 omogeneous patient populations and as target engagement biomarkers to verify similarity of effects ac

85 recorded in RSC were less modulated by task engagement but showed surprisingly similar spatial tunin

86 erred conformers of KO and KDO favor hItln-1 engagement, but those of the heptoses do not.

87 and reduce the extent of aberrant translocon engagement by a model substrate diminish cellular depend

88 l receptor, a technology known as bispecific engagement by antibodies based on the T-cell receptor (B

89 Our results indicated that LAIR-1 engagement by collagen or by complement C1q (C1Q, which

90 IgE-ICs are noninflammatory through reduced engagement by FcepsilonRI but increased targeting of the

91 Unlike traditional drugs, where target engagement can be described by a simple bimolecular equi

92 e mutation at Bahcc1 to disrupt its H3K27me3 engagement causes partial postnatal lethality, supportin

93 Through community engagement, community-based H. pylori screening and stom

94 rgans of animal models and subsequent target engagement confirmation is a challenge to drug discovery

95 The task force assessed the design, user engagement, content, potential of inducing behavioral ch

96 ness change of the underlying substrate post engagement, controlled by the operating temperature.

97 Here, we trained mice on tasks where task engagement could be distinguished from sensory accuracy.

98 creases in cognitive load above initial task engagement did not affect the relationship between metab

99 urther research is needed to understand care engagement disparities.

100 n, and instead suggest that the MD network's engagement during language processing reflects effort as

101 spinesib is critical for adequate tumor cell engagement during mitosis, when tumor cells are vulnerab

102 Task engagement elicited a marked increase in the association

103 ake within 90 days of HIV testing, programme engagement (follow-up visit attendance at week 4, week 1

104 ctices and emerging innovations in community engagement for education, for research, and for practice

105 s exhibited an increased requirement for TCR engagement for survival.

106 ven the diversity of observed NOTCH receptor engagement, gamma-secretase modulation was rationalized

107 itive predictive path between digital social engagement, general smartphone use, and physical activit

108 to our previous study in the ferret IC, task engagement had little effect on sound-evoked activity in

109 en feature carboxylic acid motifs for target engagement, have emerged as a class of potentially power

110 ist of recommendations regarding stakeholder engagement: HEM modeling, including model structure, sco

111 ystem-wide proteomic survey of translational engagement identifies a family of oxygen-regulated RBPs

112 Despite the importance of TLR engagement in activating proinflammatory macrophages, re

113 oreal ancestral species rather than proof of engagement in arboreal activities during life.

114 covery of compound 1, which exhibited target engagement in autoradiography (ARG) studies in brain sli

115 uman immunodeficiency virus testing improved engagement in care and viral suppression 12 months after

116 ling and partner services data should inform engagement in care for previously diagnosed partners.

117 mational booklet outlining opportunities for engagement in care of the patient during their ICU stay.

118 llowing outcomes were assessed in both arms: engagement in care, viral suppression, and reasons for n

119 properties of language can increase science engagement in children's daily lives.

120 ssing these mechanisms could promote science engagement in early childhood.

121 of social connections, as well as on active engagement in groups and communities.

122 ation between a brief self-report measure of engagement in HIV care (the Index) and suboptimal retent

123 crease, p < 0.001), and facilitating patient engagement in HIV primary care (13% increase, p < 0.001)

124 for GCGR target distribution and drug target engagement in humans.

125 gical markers of proactive cognitive control engagement in individuals with schizophrenia.

126 cterial effector evolved to target ATG16L1's engagement in intracellular traffic rather than in LC3 l

127 Humans engagement in music rests on underlying elements such as

128 l providers and staff), and enhancing client engagement in primary HIV care to reduce emergency and i

129 Compound 12 was found to have robust target engagement in rat with an ED(70) of 1.4 mg/kg.

130 lective experiences evoking strong emotional engagement in the audience.

131 ch indicates that ligand recognition and TLR engagement in the endolysosome occurred normally.

132 ribes perspectives gained over many years of engagement in the field of organic electrochemistry.

133 Self-regulation interventions raised student engagement in the first few weeks but not final completi

134 Descriptive data on participant engagement in the intervention are reported, and outcome

135 spondents reported high attendance rates and engagement in the intervention.

136 gical states and reflects subjectively rated engagement in the movie.

137 irst, we offer strategies to enhance patient engagement in trial design, convenient participation, an

138 piperidine 22m, where we demonstrated target engagement in two animal models of neuropathic lysosomal

139 Its optimization led to rapid BTK engagement in vivo and fast clearance, further limiting

140 ts have failed to achieve significant target engagement in vivo, possibly because the protein is pres

141 d small-molecule probe (ABP) to track target engagement in vivo.

142 Agonistic VISTA engagement increased T cell tolerance by promoting antig

143 skills or experience, 6) patient and family engagement is important, and 7) program evaluation and o

144 ning proteins, yet what governs their proper engagement is poorly understood.

145 attentional drag theory, whereby attentional engagement is prolonged when features change smoothly.

146 The overarching message from this engagement is that while patients value longevity, reduc

147 stablish a culture of excellence and faculty engagement, leading to innovation in the classroom and l

148 effects of AV-101 (720 and 1440 mg) on NMDAR engagement measured by gamma-frequency band auditory ste

149 Here we describe a complementary target-engagement method, HIPStA (Heat Shock Protein Inhibition

150 These results corroborate brain target engagement of 1440 mg AV-101 in humans, consistent with

151 ems to be open to learning and adapting, the engagement of a diverse range of stakeholders and tailor

152 lpha7 nAChRs in rat SOC, suggesting possible engagement of ACh-mediated modulation of neural activity

153 evaluate the activation of related PRRs and engagement of adaptors.

154 rsity of our membership and work towards the engagement of all members, from diverse backgrounds at a

155 rgent clones had acquired resistance through engagement of alternative receptor tyrosine kinases eith

156 TCR re-engagement of antigen-specific CD4(+)CD8alphaalpha(+) IE

157 site, where highest viral loads and initial engagement of antiviral defenses are expected.

158 he release of cyt c into the cytosol for the engagement of apoptosis.

159 th (GMNS) was introduced to estimate overall engagement of areas into short-lived networks related to

160 ryoelectron microscopy (cryo-EM) showed that engagement of both eIF2B regulatory sites by two eIF2(al

161 in PIK3IP1-deficient B cells in response to engagement of both the BCR and CD40 or strong cross-link

162 the ability to validate the cellular target engagement of candidate inhibitors.

163 These findings reveal that the engagement of CAs in some brain regions is essential for

164 n and memory of faces and scenes implies the engagement of category-specific computational hubs in th

165 ohort, CM is associated with cerebrovascular engagement of CD3+CD8+ T cells, which is exacerbated by

166 ty of Hyal2-expressing myeloid cells, as the engagement of CD44 receptor with specific mAb triggered

167 Engagement of cell surface receptors by viruses is a cri

168 a release of immunosuppressive cytokines and engagement of checkpoint receptors.

169 NIPBL and DNA promote the engagement of cohesin's ATPase head domains and ATP bind

170 uld mediate virus neutralization, whereas Fc engagement of Fc-gamma receptors (FcgammaRs) could media

171 biased agonism focusing on the differential engagement of G proteins versus beta-arrestins are commo

172 tions between words have been extracted, the engagement of goal-directed attention is key to enable r

173 Our study thus reveals dual-interface engagement of GSDMD by caspase-1, which may be applicabl

174 This work reveals key determinants of the engagement of IL-11 by IL-11Ralpha that may be exploited

175 Ms secreted the cytokine TGF-beta that, upon engagement of its receptors in breast cancer cells, supp

176 concepts of emotion perception by suggesting engagement of limbic effective connectivity in recognizi

177 Better engagement of marginalized populations will not succeed

178 host cell receptors to which NTHI binds via engagement of multiple adhesins.

179 Its efficient induction requires direct engagement of myeloid progenitors in the bone marrow.

180 We also uncovered active engagement of NCMs in regulating the behaviour of CMs, e

181 ysiological subsets of pain, evaluate target engagement of new drugs and predict the analgesic effica

182 rgeted as it involves multiple steps and the engagement of numerous initiation factors.

183 This resulted in the engagement of oxidative phosphorylation (OXPHOS) driven

184 tice guidelines in this area should focus on engagement of patients and families in the development p

185 fragments of PGN are proinflammatory through engagement of pattern recognition receptors (PRR) on res

186 Diminished engagement of PD-1 within the tumor, but not acute ex vi

187 d further progress will be made by continued engagement of physicians, scientists, and patients.

188 Target engagement of PI3Kdelta and HDAC6 by 48c was demonstrate

189 to demonstrate the effective cellular target engagement of PI5P4Kalpha and -beta by the inhibitors in

190 ining effective surveillance systems and the engagement of policy makers to turn surveillance finding

191 Within this framework, wide-spread engagement of populations of neurons produces representa

192 ce the intracellular accumulation and target engagement of PROTACs and develop RC-1 as a reversible c

193 ng the stepwise recruitment, activation, and engagement of proteins within FAs.

194 athway, is, at least in part, because of the engagement of PTCH proapoptotic activity.

195 s all behavioural phases revealed a distinct engagement of S1 and lateral OFC, with S1 neural activit

196 s have thus far focused on safety and target engagement of senolytic agents that clear senescent cell

197 of bypassing current targeted therapies via engagement of several growth promoting pathways.

198 mal shift assay that reliably detects target engagement of SHP2 inhibitors.

199 disparities research, we probe this "closer engagement of social epidemiology with formal causal inf

200 The biodistribution and target engagement of soticlestat was assessed in mice.

201 cortical parameters, possibly reflecting the engagement of specific neurophysiological substrates, an

202 ctivity and collective migration through the engagement of the adenosine receptor 1 (ADORA1) and AKT

203 However, engagement of the B cell receptor (BCR) induced both exp

204 embly of triple-helical domains or by direct engagement of the C-Pro itself.

205 ntrol mG(s) coupling and defined how agonist engagement of the CLR extracellular and transmembrane do

206 atory responses, infection results in robust engagement of the complement and coagulation pathways.

207 Our data thus link engagement of the CRN to the temporal dynamics of episod

208 etry and mutagenesis studies reveal that the engagement of the distal C-terminus of Galphai/o with th

209 Here, we demonstrate that engagement of the eukaryotic CMG helicase with template

210 SHP2 was also phosphorylated upon engagement of the extracellular matrix (ECM) via focal a

211 In addition to engagement of the GSDMD N- and C-domain linker by the ca

212 of those compounds likely resulted from the engagement of the immunomodulatory function of CD31 sign

213 ts and ClpS-ClpA chimeras, we establish that engagement of the intrinsically disordered N-terminal ex

214 by a clonality bottleneck that restricts the engagement of the large diversity of MBC clones generate

215 ronization reflect differential anticipatory engagement of the network nodes and functional units tha

216 on development, providing evidence of target engagement of the neural systems associated with reward.

217 e receptor 4 (TLR4) signaling and subsequent engagement of the NLRP3 inflammasome.

218 ponding T cell repertoires and the nature of engagement of the respective antigen-presenting molecule

219 action that is controlled by acetylation and engagement of the Smc ATPase head domains.

220 ance and is often neuroprotective, excessive engagement of the system can be deleterious.

221 vel dual mechanism of activation mediated by engagement of the T-cell receptor or of CD16.

222 dependence is an aspect of the collaborative engagement of the traditions of Buddhism and science-a p

223 Following engagement of their cognate receptors, T cells undergo m

224 We propose that the engagement of these homeostatic feedback circuits by int

225 ork for understanding how hyper- versus hypo-engagement of these networks may underlie distinct featu

226 The engagement of these patterns during food choices modulat

227 eoblast differentiation and function through engagement of TLR2.

228 erein as TLR1/2), TLR7 or TLR9, but not upon engagement of TLR3 or TLR4.

229 Our results demonstrate that simultaneous engagement of TLR7 and RIG-I pathways using particulate

230 tment." The workshop facilitated cooperative engagement of transplant community stakeholders, includi

231 f the polyomavirus family as it requires the engagement of two types of glycans, sialylated oligosacc

232 antiviral compounds against HCMV via direct engagement of virions.IMPORTANCE Human cytomegalovirus (

233 SCM) heterogeneity results from differential engagement of Wnt signaling.

234 rse methodologies (for example, social media engagement on Facebook) and nationally representative sa

235 Importantly, DR3 engagement on ILC2s significantly ameliorates glucose to

236 These findings provide evidence that EP2 engagement on peripheral immune and brain endothelia con

237 , land, and property violations, third-party engagement outside of and during customary court hearing

238 erscore the importance of early ART and care engagement, particularly at hospital discharge.

239 sponse in forest change rate to intervention engagement (person-contacts with intervention activities

240 and switches signaling adaptor; surface TLR4 engagement predominantly induces proinflammatory cytokin

241 alphaCA, YY4-yne, that serves as a cellular engagement probe for MPC2 in click chemistry-enabled wes

242 To determine whether engagement-related state changes depended on the relevan

243 , the underlying mechanisms regulating their engagement remain unclear.

244 hromosomal process is recognized as "homolog engagement" remains unclear.

245 esponse in EM and TEMRA CD8(+) T cells, CD16 engagement resulted in selective activation of TEMRA CD8

246 with this link between desynchronization and engagement, rewards had a long-lasting desynchronizing e

247 nstruments warrant further testing, Mealtime Engagement Scale demonstrated moderate psychometric qual

248 Future testing of Mealtime Engagement Scale is needed in larger diverse samples in

249 ow psychometric quality, except for Mealtime Engagement Scale with moderate psychometric quality in a

250 ors, not as energy substrates or through GPR-engagement signaling in these B cell-intrinsic processes

251 eir use for targeted delivery and for target engagement studies.

252 or are less effectively coupled to receptor engagement, such as beta-arrestin recruitment.

253 ects on clinical symptoms, but not on target engagement, suggesting a higher dose may yet be needed,

254 such as joint attention, language and social engagement, that may affect further development and coul

255 ggest that achieving higher rates of patient engagement through EHR portals will require paying more

256 mpounds (e.g. ethanol) can increase stressor engagement through modulation of neurotransmitter system

257 Health into kidney care will require patient engagement to develop effective interventions and issues

258 ss, mitigating complications and maintaining engagement to environmental issues.

259 completed a multi-year process of strategic engagement to identify future research priorities and op

260 for protein binding, very recently covalent engagement to novel E3's has proven fruitful in TPD appl

261 anning, implementing, and evaluating teacher engagement to support the broader impact goals of your r

262 tion, testing, treatment, engagement, and re-engagement) to identify combination strategies providing

263 e psychometric quality in assessing mealtime engagement toward people with dementia.

264 reliability and validity to assess mealtime engagement toward people with dementia.

265 he endogenous T cell receptor (TCR), antigen engagement triggers the formation of CAR microclusters t

266 anistic perspective, we found that cognitive engagement was accompanied by activation of the endogeno

267 Docetaxel drug-target engagement was assessed by confocal anti-tubulin immunof

268 T cells was significantly impaired when CD28 engagement was blocked, but unaffected by CTLA-4 activat

269 In the present study, viewer engagement was experimentally manipulated in order to: (

270 Promising efficacy and evidence of target engagement was observed in DMD patients after 24 weeks o

271 iver cells, and compound activity and target engagement were confirmed in vivo in mouse liver and gut

272 xpression of HSCs activation markers and FXR engagement were evaluated at 24, 96 and 144 hours.

273 c, and suggested a model for initial peptide engagement where early interactions between the far N-te

274 nation learning and was correlated with task engagement, which, in turn, could be regulated by chemog

275 ional changes of the holoenzyme required for engagement with -10 promoter element, although by a mech

276 suring adherence, partly due to poor patient engagement with 99DOTS.

277 This selective targeting resulted in engagement with BD-containing proteins in cells, resulti

278 ate B-cell receptor signaling pathways after engagement with calcium-dependent lectins expressed by t

279 economics, and politics, and through direct engagement with civil society, that science can illumina

280 ing gastric dysrhythmias during incentivized engagement with disgusting stimuli.

281 nd priorities for future research on patient engagement with EHR data through patient portals, These

282 cruitment of complement component C1q or the engagement with Fcgamma receptors (FcgammaRs).

283 results in reduced C1q binding and increased engagement with FcgammaR, maintains the opsonophagocytic

284 em, so how has the internet changed people's engagement with health information?

285 ace of SARS-CoV-2 is a major antigen and its engagement with human ACE2 receptor plays an essential r

286 ing intubation, the use of high-flow oxygen, engagement with infectious disease consultants, and card

287 rce of amino acids; a role driven by albumin engagement with its cognate cellular recycling neonatal

288 smartphone apps and might facilitate patient engagement with many technologies.

289 ications to their growth and development and engagement with microorganisms that facilitate their cap

290 otch-dependent effects required simultaneous engagement with OP9 stromal cells and were also stage-sp

291 Direct engagement with providers using academic detailing coupl

292 cells, NUCKS1 prevents RAD54's inappropriate engagement with RAD51AP1.

293 rfere with the development of children's own engagement with science.

294 turally alters the SL receptor to enable its engagement with signaling partners.

295 Efficient engagement with the envelope glycoprotein membrane-proxi

296 achment is triggered by an early step of MS2 engagement with the F-pilus or T4SS.

297 ars examined how cumulative disadvantage and engagement with the shelter system altered youths' traje

298 argo, final release to the cell surface, and engagement with their cognate receptors on cytotoxic T l

299 We have compared these articles, and reader engagement with them, to other articles on Wikipedia.

300 Early engagement would provide inputs to inform strategic vacc