ライフサイエンスコーパス: engulfment

1 ng their brief phagocytic role in nurse-cell engulfment.

2 ilencing significantly affected cryptococcal engulfment.

3 s significantly impaired apoptotic cell (AC) engulfment.

4 idespread proteolysis, nucleolysis, and cell engulfment.

5 ctor 6 (Arf6) plays a key role in fibrinogen engulfment.

6 IIQ(H120S) interact with SpoIIIAH throughout engulfment.

7 ic capacity but reduced motility and synapse engulfment.

8 body-coated solid particles, signaling their engulfment.

9 uole maturation and nutrient recovery during engulfment.

10 xtension during cell migration and bacterial engulfment.

11 e two proteins also form a backup system for engulfment.

12 e process of Entamoeba histolytica host cell engulfment.

13 eptor MARCO, which was required for enhanced engulfment.

14 spread that specifically promotes protrusion engulfment.

15 iently Rab14 positive within 2 min following engulfment.

16 rylated, which is required for Jedi-mediated engulfment.

17 nd mediates changes of F-actin that drive AC engulfment.

18 there is an optimum ligand density for quick engulfment.

19 th receptors being driven toward the site of engulfment.

20 rane-surface tension that produce successful engulfment.

21 cludes signaling and captures both stages of engulfment.

22 ype macrophages is not sufficient to enhance engulfment.

23 ce neutrophil binding, motility, and biofilm engulfment.

24 regulation of the luminal pH after particle engulfment.

25 d-absent hemisphere to complete the particle engulfment.

26 nclear whether PG surrounds prespores during engulfment.

27 creased C3 deposition and microglial synapse engulfment.

28 orespore in a phagocytic-like process called engulfment.

29 RPX2 binds C1q and blocks microglial synapse engulfment.

30 ins to cytoskeletal forces to drive particle engulfment.

31 els is used to measure successful phagocytic engulfment.

32 val of C. glabrata in response to macrophage engulfment.

33 onical and canonical autophagy in neutrophil engulfment.

34 iated with a decreased success of phagocytic engulfment.

35 bsequently clear neighbouring loser cells by engulfment.

36 m to achieve efficient membrane scission and engulfment.

37 e embedded, impact the success of phagocytic engulfment.

38 n is not completely degraded at the onset of engulfment.

39 ating macrophage properties during and after engulfment.

40 receptors to initiate signaling pathways for engulfment.

41 esting a phagocytic-like process for vesicle engulfment.

42 macrophage filopodia in particle capture and engulfment.

43 counteract the torque caused by rapid water engulfment [6].

44 Interventions that boost glial engulfment activity, however, can substantially reverse

45 mixture with PEG, which induces cell fusion, engulfment, aggregation or lysis.

46 Both engulfment and a channel-like function may be ancestral

47 ECM) and that its loss leads to impaired ECM engulfment and a concomitant accumulation of ECM protein

48 es of myofibroblasts in regulating apoptotic engulfment and a fundamental importance of these cells i

49 If engulfment and body acceleration are temporally distinct

50 Engulfment and cell motility 1/dedicator of cytokinesis

51 Previously we reported that engulfment and cell motility protein 1 (ELMO1) in macrop

52 have demonstrated that polymorphisms in the engulfment and cell motility protein 1 gene (ELMO1) are

53 GEFs are specific for RAC, and require ELMO (engulfment and cell motility) proteins for function.

54 Nr4a1-deficient mice have impaired thymocyte engulfment and clearance.

55 The increased engulfment and degradation of RBC was independent of IFN

56 han the opsonizing fragment that facilitates engulfment and destruction of targets by phagocytes.

57 f the molecular mechanisms that regulate the engulfment and digestion of the efferocytic cargo.

58 uter keratinocytes carry out an entosis-like engulfment and entrainment of underlying basal cells, co

59 that membrane topology at the final stage of engulfment and FisB-cardiolipin interactions ensure that

60 ellular force patterns throughout phagocytic engulfment and force dynamics in the cytotoxic T-cell im

61 gnition of dying cells through to phagocytic engulfment and homeostatic resolution, and highlight the

62 Those effects are due to defective engulfment and impaired LAP-mediated clearance of apopto

63 are impaired in the morphological process of engulfment and late forespore gene expression and freque

64 Engulfment and Motility (ELMO) proteins are involved in

65 ic bifunctional molecule able to mediate the engulfment and phagocytosis of C. albicans cells by huma

66 an homolog proteins), which is essential for engulfment and phagosome maturation.

67 rodegenerative diseases, microglial synaptic engulfment and profound synapse loss were observed.

68 l environment, including ones that stimulate engulfment and proliferation.

69 The engulfment and subsequent degradation of apoptotic cells

70 targeted to LDs, where it mediates membrane engulfment and subsequent degradation, is unclear.

71 ing is critical both for phagocytic particle engulfment and subsequent phagosomal maturation to a deg

72 phagy, involves membrane mobilisation, cargo engulfment and trafficking of the newly formed autophagi

73 cation, and the phagocytosis-like process of engulfment, and also the key experimental advances that

74 factor 8 (MFG-E8), which promotes apoptotic engulfment, and determined that serum response factor is

75 a new model for how PG synthesis might drive engulfment, and obviates the need to synthesize a PG lay

76 mutants of C. difficile result in anomalous engulfment, and that disruption of the SpoIIQ LytM domai

77 sential for fission of mitochondria prior to engulfment, and the outer mitochondrial membrane protein

78 l spread that involves protrusion formation, engulfment, and vacuolar escape.

79 the spoIIQ or spoIIIAH mutants that complete engulfment are impaired in post-engulfment, forespore an

80 percentage of neutrophils showing successful engulfment as a function of the elastic modulus of the g

81 polystyrene beads, we measure the fractional engulfment as a function of time and demonstrate that ph

82 Live-cell Ca(2+) imaging and engulfment assays revealed that Ca(2+) response and phag

83 the phagophore-assembly site, Atg24 in cargo engulfment, Atg26 in cytoplasm-to-vacuole targeting, and

84 lfment increases dramatically, with complete engulfment attained soon afterwards.

85 al mechanism for the creation of a force for engulfment based on the coordination between cell wall s

86 We find a whole range of different engulfment behaviors with some ellipsoids engulfing fast

87 CAV1(-/-) RPE in situ showed normal particle engulfment but delayed phagosome clearance and reversed

88 orespore-protein SpoIIQ leads to zipper-like engulfment, but quantitative understanding is missing.

89 tudies suggest a new role for Rac1-dependent engulfment by airway epithelial cells and in establishin

90 Here, we show that apoptotic corpse engulfment by Drosophila macrophages is an essential pri

91 trusion of PS on LCs, which in turn promoted engulfment by E2/ERalpha-activated macrophages that was

92 myelin debris is required for its effective engulfment by endothelial cells and that the autophagy-l

93 cells in a mouse model resulted in defective engulfment by epithelial cells and aberrant anti-inflamm

94 ansgene was used that highlights cell corpse engulfment by fluorescence microscopy.

95 DL) cholesterol into the artery wall and its engulfment by macrophages, which leads to foam cell form

96 IGF-1 did not alter engulfment by macrophages.

97 phagy inducer rapamycin augmented neutrophil engulfment by macrophages.

98 the molecular pathways that can mediate cell engulfment by microglia and find selective downregulatio

99 r leaflet of transduced cells triggers their engulfment by microglia through TAM receptor-dependent m

100 vated presynaptic PS exposure and reduced PS engulfment by microglia.

101 to CNS invasion and demonstrates that T cell engulfment by myeloid cells can be therapeutically explo

102 ithin the intestinal lumen, leading to their engulfment by neutrophils, while phenotypically avirulen

103 tosis in vivo is their rapid recognition and engulfment by phagocytic cells (a process called efferoc

104 by which apoptotic tissue is recognized for engulfment by phagocytic cells such as macrophages.

105 In both processes, engulfment by the cell depends critically on both partic

106 of all lineages, are adherent passengers for engulfment by the ectodermal epithelium.

107 Internalization was marked by a process of engulfment by thin membrane extensions from the endothel

108 cavenging of extracellular macromolecules by engulfment can sustain cell growth in a nutrient-deplete

109 cy of foraging is driven both by the whale's engulfment capacity and the comparative locomotor capabi

110 nd the intracellular signaling intermediates engulfment cell motility 1 (ELMO1) and Rac1, as ABCA1 in

111 ver the surface of targeted particles during engulfment, cells must change shape through extensive me

112 During engulfment, CHC is tyrosine phosphorylated, which is req

113 In these whales, engulfment coincided largely with body deceleration; how

114 function of the complex, required following engulfment completion.

115 ne signaling and immune function, and debris engulfment contributions that this class provides throug

116 , we speculate that the effects of promoting engulfment/degradation of cell debris may go beyond mere

117 ngle amino acid substitution (H120S) impairs engulfment differently.

118 PACSIN2 promote L. monocytogenes protrusion engulfment during spread, and that PACSIN2 specifically

119 CD47 suppresses multiple different pro-engulfment "eat me" signals, including immunoglobulin G

120 ng, migration, symmetry breaking, nurse-cell engulfment, egg-shell formation, and corpus luteum signa

121 tionary innovation, allowing fast and robust engulfment even for large particles.

122 The unique engulfment filtration strategy of microphagous rorqual w

123 hat complete engulfment are impaired in post-engulfment, forespore and mother cell-specific gene expr

124 The engulfment function of macrophages relies on complex mol

125 e polymorphisms (SNPs) in the apoptotic cell-engulfment genes ELMO1, DOCK2, and RAC1 linked to rheuma

126 Both approaches decreased binding and engulfment >40%.

127 ntly contribute, which can even lead to fast engulfment in [Formula: see text] 60 [Formula: see text]

128 e to investigate the origin of fast bistable engulfment in absence of the cell wall.

129 ic cells, ced-8 is important for cell corpse engulfment in C. elegans.

130 tion of conserved macrophage-like program of engulfment in chemotherapy-induced senescent cell lines

131 he medium osmolarity in experiments prevents engulfment in line with our predictions.

132 physical principles are likely applicable to engulfment in other cell types, e.g. during phagocytosis

133 Possibly, SpoIIQ(H120S) supports normal engulfment in some cells but not a second function of th

134 is study investigated whether apoptotic cell engulfment in the murine lung impacts the development of

135 leading to the notion that the capacity for engulfment in vivo is vast.

136 We propose a simple model for engulfment in which the junction between the septum and

137 t approximately half-engulfment, the rate of engulfment increases dramatically, with complete engulfm

138 Unexpectedly, myelin debris engulfment induces endothelial-to-mesenchymal transition

139 ic ligands are the key to cargo recognition, engulfment initiation, and activity regulation.

140 cts with cell surface gangliosides, allowing engulfment into a membrane vesicle by a clathrin-indepen

141 nd evidence that microglia-mediated synaptic engulfment is enhanced with increased expression of C4.

142 How GULP promotes engulfment is not known.

143 During the first stage, engulfment is relatively slow and progressively slows do

144 osome marker, suggesting that ABCF1-mediated engulfment is through a phagocytic pathway.

145 Viral-engulfment leads to C3 release from platelets as a funct

146 obacterium tuberculosis (Mtb) infection, the engulfment ligand annexin1 is an important mediator in D

147 DD1alpha appears to function as an engulfment ligand or receptor that engages in homophilic

148 Although some of the engulfment ligands involved in efferocytosis have been i

149 er receptor Draper and downstream phagocytic engulfment machinery.

150 Forespore engulfment may thus not only be an ideal model system to

151 racterized by acceleration to high speed and engulfment of a large volume of prey-laden water [1-4].

152 f phagocytosis, here defined as the complete engulfment of a piece of foreign material, depends on th

153 be recognized by Toll-like receptors (TLRs), engulfment of ACs does not initiate inflammation in heal

154 s rapidly underwent apoptosis in response to engulfment of an extrusion, while uptake of an equivalen

155 ewires the tumor microenvironment to inhibit engulfment of antibody-targeted tumor cells.

156 or expressed on macrophages that enables the engulfment of apoptotic bodies, so-called efferocytosis.

157 Engulfment of apoptotic cells by macrophages (efferocyto

158 The engulfment of apoptotic cells by phagocytes, a process r

159 ndicate that stimulation of LXR enhances the engulfment of apoptotic cells via regulating directly an

160 phages can also be induced by the successful engulfment of apoptotic cells, highlighting the importan

161 Following MFG-E8-mediated engulfment of apoptotic cells, myofibroblasts acquired a

162 brain angiogenesis inhibitor 1 (BAI1) in the engulfment of apoptotic GECs using human tissue and cell

163 d knockdown in glial precursors prevents the engulfment of apoptotic neurons.

164 This review will highlight how the engulfment of apoptotic neutrophils by human phagocytes

165 The engulfment of apoptotic polymorphonuclear cells (PMN) du

166 After engulfment of apoptotic tumor plasma cells via CD91, bon

167 gulatory function of macrophage TIM-4 in the engulfment of apoptotic/necrotic bodies in innate immuni

168 ation of macrophage phagosomes following the engulfment of C. albicans cells.

169 es that enable antitumor activity, including engulfment of CD47(+) cancer cells.

170 ssociated with loss of Cdkn2b and normalized engulfment of Cdkn2b-deficient cells.

171 refinement deficits along with an increased engulfment of climbing fiber synaptic elements by microg

172 ive cell processes and lysosomes, suggesting engulfment of complement-tagged synapses by microglia.

173 Autophagy involves engulfment of cytoplasmic contents by double-membraned a

174 g pathway, one that likely leads to vacuolar engulfment of cytoplasmic proteins and recycling of cell

175 s of cells and molecules responsible for the engulfment of dead cells in the infarcted area remain la

176 e dampening of pro-inflammatory signals upon engulfment of dying cells and prevention of autoantigen

177 Mitophagy, the selective engulfment of dysfunctional mitochondria by autophagasom

178 The ex vivo or in vivo engulfment of EMPs or cMPs by peripheral blood monocytes

179 xt, we identified the mechanism by which the engulfment of erythrocytes with exposed phosphatidylseri

180 es metabolism toward nutrient acquisition by engulfment of extracellular fluids and suggest possible

181 Engulfment of extracellular material by phagocytosis or

182 o allow for efficient membrane expansion and engulfment of extracellular material.

183 ogenesis, host genes involved in the initial engulfment of fungi and subsequent stages of infection a

184 e transfer to macrophages by influencing the engulfment of infected cells.

185 Impairment in the engulfment of Jurkat T cells, neutrophils, and epithelia

186 Phagosomes form during engulfment of large particles and become increasingly ac

187 We further confirmed E2-dependant engulfment of LCs by real-time 3D imaging.

188 this process (macrolipophagy) results in the engulfment of LDs within double-membrane delimited struc

189 Ex vivo engulfment of lyso-PS(high) neutrophils (95% viable) by

190 quired FIP200 and TBK1, both involved in the engulfment of microbes by xenophagy.

191 f CHC in HeLa cells prevents Jedi-1-mediated engulfment of microspheres, and knockdown in glial precu

192 f larger apoptotic cells was reduced whereas engulfment of microvesicles was increased.

193 le for autophagosome formation and selective engulfment of mitochondria, but essential for autophagos

194 coordinating small GTPase activities during engulfment of more complex shapes and thus the full phys

195 In vitro, AIM enhanced the engulfment of necrotic debris by macrophages derived fro

196 n, are responsible for the receptor-mediated engulfment of Neisseria gonorrheae or Neisseria meningit

197 d removal of the protein component prevented engulfment of NETs, whereas complexation with LL-37 rest

198 emonstrated that diazepam limited microglial engulfment of neuronal elements and blocked CUS-induced

199 ir phenotype, and increase of the phagocytic engulfment of neutrophils by macrophages.

200 In summary, the engulfment of neutrophils by the macrophages was influen

201 enriched for phagocytic markers and observe engulfment of nonapoptotic Brn3-labeled RGCs.

202 neuronal elimination by complement-mediated engulfment of nonapoptotic neurons.

203 Moreover, NK cell killing and macrophage engulfment of our engineered cells were minimal.

204 Of note, membrane engulfment of P. aeruginosa occurred independently of ac

205 the early stages of phagocytosis enables the engulfment of particles or pathogens and receptor signal

206 In addition, macrophage engulfment of persister cells was significantly lower th

207 Engulfment of phagocytic targets requires the activity o

208 pportunities to enhance or retard macrophage engulfment of phagocytic targets such as zymosan.

209 s characterized at the cellular level by the engulfment of portions of the cytoplasm in double-membra

210 help of Vps4, ESCRT-III/Snf7 promotes direct engulfment of preexisting Grh1 containing vesicles and t

211 nals, and murine studies revealed microglial engulfment of presynaptic terminals during acute infecti

212 We find that engulfment of protein-free model lipid vesicles is promo

213 d synapses as a result of reduced microglial engulfment of PS(+) presynaptic inputs.

214 ippocampal and retinogeniculate synapses and engulfment of PS-labeled material by microglia occurs du

215 293 cells, which rendered them competent for engulfment of PtdSer-bearing targets.

216 uced eye-specific segregation and microglial engulfment of RGC inputs.

217 s accumulation of the protein LC3B following engulfment of Salmonella or treatment with autophagy-ind

218 tion, autophagosomal membrane formation, and engulfment of Salmonella.

219 rtical synapse density, increased microglial engulfment of synapses and altered mouse behavior.

220 Engulfment of synapses and neural progenitor cells (NPCs

221 ry at C3-bound synapses decreased microglial engulfment of synapses and protected visual function.

222 Active microglial engulfment of synapses regulates brain development.

223 Microglia can mediate synapse loss by engulfment of synapses, likely via a complement-dependen

224 C4, recently implicated in schizophrenia, in engulfment of synaptic structures by human microglia.

225 not into the cytoplasmic interior formed by engulfment of the autophagic membrane.

226 r the bending of the plasma membrane and the engulfment of the bacterium--a key process in bacterial

227 was sufficient to achieve complete membrane engulfment of the bacterium.

228 polymerization to form a phagocytic cup for engulfment of the bead.

229 on cargos, thus facilitating the autophagic engulfment of the cargo.

230 Engulfment of the colloidosomes enables selective delive

231 ind that neuronal IL-33 instructs microglial engulfment of the extracellular matrix (ECM) and that it

232 Engulfment of the forespore by the mother cell is a univ

233 toxic oxygen metabolites and opsonization or engulfment of the microbes, but depended on beta(2) inte

234 was attributed to (i) cation exclusion, (ii) engulfment of the nascent chain by the hydrophobic pore

235 persister cells was significantly lower than engulfment of total population, both before and followin

236 urthermore, blocking CD47 signaling promotes engulfment of tumor cells by macrophages in vitro and in

237 phagocytes, including chemotaxis toward and engulfment of unicellular organisms or cell debris.

238 rotein around neurons caused by insufficient engulfment of VEGF by VEGFR2-deficient neurons.

239 ges coordinate the recognition, capture, and engulfment of zymosan bioparticles.

240 ing and impairs their migration to, and thus engulfment of, dying cells.

241 pend on pathways that control cell death and engulfment or muscle arm extension.

242 lthough their timely clearance by macrophage engulfment, or efferocytosis, is critical for efficient

243 tica correlates with the degree of host cell engulfment, or phagocytosis, and E. histolytica phagocyt

244 aces epn-1 and chc-1 in the same cell-corpse engulfment pathway as ced-1, ced-6 and dyn-1.

245 Our findings reveal a novel function of the engulfment pathways and provide a better understanding o

246 Therefore, we propose that components of the engulfment pathways promote programmed cell death by enh

247 Components of the conserved engulfment pathways promote programmed cell death in Cae

248 hibited temporally distinct acceleration and engulfment phases, with humpback whales reaching maximum

249 ngs were recapitulated in vivo; the enhanced engulfment phenotype resulted in increased bacterial cle

250 prespore and increase in size and number as engulfment proceeds.

251 During the engulfment process, an essential channel, the so-called

252 ize particles via a chemoattractant-mediated engulfment process.

253 ecA-Gb3 interaction is adequate to drive the engulfment process.

254 IIQ assembles foci along the path defined by engulfment proteins degrading peptidoglycan.

255 SpoIIQ interacts with both SpoIIIAH and the engulfment proteins or their peptidoglycan cleavage prod

256 r increased by the additional absence of the engulfment proteins.

257 ays: SpoIIIAH and the SpoIID, SpoIIM, SpoIIP engulfment proteins.

258 ring and solid-state (2)H NMR correlate with engulfment rates measured by flow cytometry.

259 ed for phagocytosis mediated by the nematode engulfment receptor CED-1.

260 Here we show that the glial engulfment receptor Draper is protective in a Drosophila

261 ction of MMP-1 requires the highly conserved engulfment receptor Draper, as well as AP-1 and STAT92E.

262 ere, we show that the highly conserved glial engulfment receptor Draper/MEGF10 provides neuroprotecti

263 n transcriptional up-regulation of the glial engulfment receptor Draper; there is extension of glial

264 is mediated, in part, through the mammalian engulfment receptor Jedi-1.

265 this study, we report that the absence of an engulfment receptor leads to a pronounced accumulation o

266 Draper/Ced-1/MEGF-10 is an engulfment receptor that promotes clearance of cellular

267 which controls the expression of the Draper engulfment receptor.

268 equal, and that compensation among specific engulfment receptors is context and tissue dependent.

269 ticulin, a ligand required for activation of engulfment receptors on phagocytic cells.

270 e kinematics of lunge feeding, the timing of engulfment relative to body acceleration has been modele

271 Stable engulfment resulted in the death of the engulfed cells,

272 ting on apoptosis, M. leprae recognition and engulfment, Schwann cell (SC) demyelination, epithelial-

273 ith experimental time-lapse microscopy, with engulfment sensitive to the number of SpoIIQ-SpoIIIAH bo

274 s downstream of the Draper/Src42a/Shark/Rac1 engulfment signaling pathway.

275 pruning and reveals, unexpectedly, that the engulfment signaling pathways engaged by glia depend on

276 hat glia promote neurite destruction through engulfment signaling.

277 ypassed CD47-mediated inhibition and rescued engulfment, similar to the effect of a CD47 function-blo

278 The presence of PG throughout engulfment suggests new roles for PG in sporulation, inc

279 Mecp2(LSL/y)) had little effect on excessive engulfment, synapse loss, or phenotypic abnormalities.

280 crophage spreading across the surface of the engulfment target.

281 However, during engulfment, the lipid content of the apoptotic cells tri

282 During engulfment, the MC membrane migrates around the FS and p

283 phages toward C. albicans cells, the rate of engulfment, the overall uptake of fungal cells, or early

284 However, at approximately half-engulfment, the rate of engulfment increases dramaticall

285 During engulfment, the whale accelerates, opens its jaw until i

286 drive cytoskeletal rearrangements and target engulfment through Rac1.

287 via ubiquitin binding and mediate autophagic engulfment through their association with microtubule-as

288 The data shows an increase in the average engulfment time for increased target size, for spherical

289 attack data to model how predator speed and engulfment timing affected capture rates.

290 odulate the coordination of acceleration and engulfment to optimize foraging efficiency by minimizing

291 enotypic conversion, directly linking debris engulfment to tissue repair.

292 back whales are, thus, incentivized to delay engulfment until they are very close to a prey school, e

293 Dendritic cells (DCs) are specialized in Ag engulfment via a wide variety of uptake receptors on the

294 (via MFF phosphorylation) and autophagosomal engulfment (via TBK1 activation) in a PINK1-Parkin indep

295 of SpoIIQ-SpoIIIAH while the requirement for engulfment was alleviated through the emergence of redun

296 in vitro model of microglia-mediated synapse engulfment, we demonstrate increased synapse elimination

297 promotes cytoskeletal reorganization during engulfment, we hypothesized that ELMO1 loss would worsen

298 e space allows the refinement of a model for engulfment, which has been known to include peptidoglyca

299 intercellular tension to promote protrusion engulfment, which represents a distinctive strategy for

300 ependent of cell-cell contact, but relied on engulfment within secreted microvesicles.