ライフサイエンスコーパス: enhancer sequence

1 a transcriptionally active site in a BNIP3L enhancer sequence.

2 cts were assayed with a probe containing the enhancer sequence.

3 of multiple nuclear factors with the PTTG 5' enhancer sequence.

4 sfection experiments, we delineated the core enhancer sequence.

5 associates with a cis-acting recombinational enhancer sequence.

6 ilar to that found in an embryonic stem cell enhancer sequence.

7 tiotemporal gene expression is encoded in an enhancer sequence.

8 icing, indicating the presence of a splicing enhancer sequence.

9 t between the silver nanocluster and the DNA enhancer sequence.

10 event PU.1-mediated IRF-4 recruitment to the enhancer sequence.

11 count for the evolutionary invariance of the enhancer sequence.

12 nt of RNA polymerase II complex to the BCAS3 enhancer sequence.

13 operty also constrains this highly conserved enhancer sequence.

14 gene has a hematopoietic-specific functional enhancer sequence.

15 expression was driven by mouse Pax3 promoter/enhancer sequences.

16 ontaining the promoter and dioxin-responsive enhancer sequences.

17 es that integrate input from multiple distal enhancer sequences.

18 activates splicing through intronic splicing enhancer sequences.

19 nal differences in the mouse and human renin enhancer sequences.

20 rs showed distinct preferences for different enhancer sequences.

21 rus but had acquired various duplications of enhancer sequences.

22 t contain either insulin or albumin promoter/enhancer sequences.

23 splicing from a number of intronic splicing enhancer sequences.

24 which function through binding to the E-box enhancer sequences.

25 l lines and contains negative regulatory and enhancer sequences.

26 at preceded stable association of Prmt5 with enhancer sequences.

27 ting a position dependence of the U3-encoded enhancer sequences.

28 ss-induced transcription factors occupy ICP4 enhancer sequences.

29 HoxD, both containing a range of appropriate enhancer sequences.

30 enetic control elements, namely promoter and enhancer sequences.

31 and DNA recombination via Pax5 and distal 3' enhancer sequences.

32 TF binding deactivating mutations (deMs) in enhancer sequences.

33 transcription factor protein binding at the enhancer sequences.

34 issue, suggesting nucleotide polymorphism in enhancer sequences.

35 d CNS depends on both its 5' promoter and 3' enhancer sequences.

36 transgenic mice, using Col2a1 gene promoter/enhancer sequences.

37 identical proximal promoter and far upstream enhancer sequences.

38 cyclic AMP response element (CRE) family of enhancer sequences.

39 loop between the PPARgamma2 promoter and an enhancer sequence 10 kb upstream that forms at the onset

40 We describe a translation enhancer sequence (3'TE) located in the 3'-untranslated

41 the PB response activity to a 290-bp distal enhancer sequence (-3483/-3194) of the UGT1A1 gene.

42 and reporter gene constructs, a 200 bp Grm6 enhancer sequence, a 445 bp Cabp5 promoter sequence, and

43 RNA recognition motif to an exonic splicing enhancer sequence, a phenomenon reversed by SRPK1 phosph

44 We searched for genomic variation in enhancer sequences across the genome, with a focus on nu

45 The associated SNPs localized to enhancer sequences active in thymus, T and B cells, and

46 ated aryl hydrocarbon receptor to the CYP1A1 enhancer sequence; additionally, NO-aspirin 2 suppressed

47 phenotypes, caused by insertion of the viral enhancer sequences adjacent to an MYB transcription fact

48 f inoculation and the presence of the PyF101 enhancer sequences affected the patterns of MCF generati

49 tion of viral mRNAs containing a translation enhancer sequence also contributes to the disassembly of

50 Consequently, divergence in enhancer sequence and activity is thought to be an impor

51 By inserting a PEG linker between an enhancer sequence and alternative splice sites, the inte

52 ted dinucleosome templates using the albumin enhancer sequence and found that site-specific binding o

53 is r-robust with respect to mutations in the enhancer sequence and identify a number of sensitive nuc

54 Pak1 associated with the upstream enhancer sequence and promoter of PFK-M and was involved

55 robustness with respect to mutations of the enhancer sequence and with respect to changes of the tra

56 n primary cells, we identified 46,802 active enhancer sequences and 164 variants that alter enhancer

57 animal regulatory genome and the make-up of enhancer sequences and confirms and generalizes principl

58 ing questions about the relationship between enhancer sequences and eRNA function.

59 Second, SR proteins bind to exonic enhancer sequences and recruit spliceosome components to

60 intrachromosomal interaction between remote enhancer sequences and the proximal promoter region thro

61 c-Fos and c-Jun bound the cyclin D1 -954 enhancer sequence, and the abundance of c-Fos within thi

62 programmed to take place at tissue-specific enhancer sequences, and our data show that the methylati

63 re evident and include a GATA motif, octamer enhancer sequences, AP-2-like sites, and Sp1 sites.

64 Both enhancer sequences appear to have equivalent activity in

65 phenocopying the effect obtained when these enhancer sequences are deleted.

66 selective pressures exerted on the EIAV LTR enhancer sequences are different from those exerted on t

67 mink cell focus-inducing (MCF) virus, the U3 enhancer sequences are tandemly repeated in the LTR.

68 viral genome, however, proximally positioned enhancer sequences are unable to confer significant leve

69 In addition, mutation of a potential enhancer sequence, around -120, led to an 80% reduction

70 per-base enhancer activities in independent enhancer sequencing assays, suggesting their importance

71 eosome positioning properties of the central enhancer sequence assembled into mononucleosome core par

72 vity 4-fold, via the AT1 receptor through an enhancer sequence at -954 base pairs.

73 NA that carries cauliflower mosaic virus 35S enhancer sequences at its right border.

74 wed that E10 splicing involved exon splicing enhancer sequences at the 5' and 3' ends of E10, an exon

75 dent of the activity of known cis-regulatory enhancer sequences at the achaete-scute complex that med

76 to-expression modeling, which interprets the enhancer sequence based on transcription factor concentr

77 and internal deletion constructs shows that enhancer sequences between nucleotides 275 and 329 are i

78 We show here that deletion of these enhancer sequences by homologous recombination is insuff

79 hancers indicates that subtle differences in enhancer sequence can have profound effects on the splic

80 ly, we show that snake and mouse orthologous enhancer sequences can display distinct expression speci

81 subsequent to the addition of the Fis-bound enhancer sequence, catalytic activity was no longer affe

82 angements displaced transcriptionally active enhancer sequences close to BCL11B without producing fus

83 omoter and at least one conserved noncoding (enhancer) sequence, CNS-5.

84 how an excess of somatic mutations in neural enhancer sequences compared with controls, suggesting th

85 A bipartite enhancer sequence (composed of the O1 and O2 operator si

86 ons of zebrafish hoxb3a/hoxb4a promoters and enhancer sequences containing regions of homology that w

87 P3 robustly bind human, but not mouse, GPR15 enhancer sequences, correlating with receptor expression

88 Translational enhancer sequences derived from viral mRNAs were used to

89 ch included mutants with deletions of exonic enhancer sequences, did not accumulate splicing intermed

90 Our results show that separable enhancer sequences direct D-mef2 gene expression in the

91 and identified approximately 6,200 candidate enhancer sequences directly from fetal and adult human h

92 However, the complete enhancer sequence directs beta-galactosidase expression

93 We demonstrate that the wealth of new enhancer sequences discerned here provides an invaluable

94 ng human chromosome-21, implicating promoter/enhancer sequence divergence as a factor, including huma

95 We have identified a 30bp ESX enhancer sequence (EES) approximately 3 kb upstream of t

96 of a previously unidentified AAV integration enhancer sequence element which functions in cis to an A

97 IL-1beta gene, while deletion of the kappaB enhancer sequences eliminated BK-stimulated CAT activity

98 clusion, SRSF1 by binding to exonic splicing enhancer sequences (ESEs) and U1 snRNPs by binding to th

99 -matrix analysis to identify putative exonic enhancer sequences (ESEs), we found multiple high score

100 Reporter constructs containing stretch enhancer sequences exhibited tissue-specific activity in

101 rovirus vector containing deletions in viral enhancer sequences expressing gammac (SIN-gammac).

102 ing sites are not critical components of the enhancer sequence for PTTG trancriptional activation in

103 s in higher eukaryotes often require distant enhancer sequences for high-level expression.

104 members, predominantly c-Rel, interact with enhancer sequences for STAT5, a key transcription factor

105 Pitx1 enhancer sequences form alternative DNA structures in vi

106 oxidant response element (ARE), a cis-acting enhancer sequence found in the promoter region of many g

107 ynaptic activity response element (SARE), an enhancer sequence found upstream of many plasticity-rela

108 Ocs elements are enhancer sequences found in some pathogen and GST promot

109 binding was not affected by PRDIV, an ATF-2 enhancer sequence from the same gene.

110 timal placement in the reporter construct of enhancer sequences from a plant virus, pea (Pisum sativu

111 We further show that JRS1 enhancer sequences from a range of gnathostome species,

112 nambiguously identified three new long-range enhancer sequences functionally in the Nkx2-5 gene in tr

113 TGF-beta and TNF-alpha response elements as enhancer sequences, functioning in the context of a hete

114 GATA enhancer sequences govern DKF-2 expression in intestine

115 This enhancer sequence has a high level of sequence homology

116 Both the epsilony-CACCC site at -114 bp and enhancer sequences (hypersensitive site 2 [HS2]) from th

117 ngs are consistent with the possibility that enhancer sequence hypervariability can alter expression

118 hermodynamics-based models that interpret an enhancer sequence in a given cellular context specified

119 Here we examine the LCT enhancer sequence in a large lactose-tolerance-tested Et

120 demonstrated in vivo binding of NR5A2 to the enhancer sequence in human hepatocytes.

121 over, LMX1B binds specifically to a putative enhancer sequence in intron 1 of both mouse and human CO

122 Identification of this second functional enhancer sequence in the 5'-promoter region of cathepsin

123 obarbital (PB)-responsive 132-base pair (bp) enhancer sequence in the CYP2B10 gene, we have delimited

124 ified as a ternary complex that bound to the enhancer sequence in vitro.

125 osine hydroxylase (TH) gene is controlled by enhancer sequences in its 5' flanking region; these enha

126 by inclusion of cauliflower mosaic virus 35S enhancer sequences in its promoter.

127 Both Enhancer and Weak Enhancer sequences in K562 cells were more active than n

128 of mRNAs that are enriched for translational enhancer sequences in the 5' untranslated region (UTR) a

129 NF-E2, a transcription factor which binds to enhancer sequences in the LCR.

130 The enhancer sequences in the Moloney murine leukemia virus

131 a profile of protein occupancy in the HTLV-1 enhancer sequences in the presence of high (MT-2) and lo

132 conformations required for interaction with enhancer sequences in the proximal promoter region of th

133 s family of transcription factors within the enhancer sequences in the viral long terminal repeats (L

134 iling, in vivo characterization of candidate enhancer sequences in transgenic mice, and targeted dele

135 are transcriptionally active at defined DNA enhancer sequences in vivo.

136 The SNPs are located in an 'enhancer' sequence in an intron of a neighboring gene (M

137 How distal transcriptional enhancer sequences interact with proximal promoters is p

138 e SL3 LTR were tested by inserting the viral enhancer sequences into a plasmid containing the promote

139 ing PCR-amplified, PCR-mutated, or synthetic enhancer sequences into the Ganesh family of P element r

140 Within the enhancer sequence is a 5' splice site sequence immediate

141 The enhancer sequence is conserved in the human Igkappa gene

142 The enhancer sequence is conserved within the human populati

143 forming to this motif, a typical purine-rich enhancer sequence is dispensable for either enhancer act

144 deletion within element C of the Hoxc8 early enhancer sequence is observed in baleen whales.

145 If a 35S enhancer sequence is placed next to Tag1, vegetative exc

146 DNA methylation in the distal enhancer sequence is significantly reduced, which invers

147 In this study the DF3/MUC1 promoter/enhancer sequence is used to regulate expression of gamm

148 Genetic variation of enhancer sequences is known to influence phenotypes, but

149 In addition, a potent splicing enhancer sequence isolated in the selection specifically

150 Furthermore, the entire HRC enhancer sequence lacks any discernible CArG motifs, the

151 ed for islet-restricted expression: a distal enhancer sequence located between -3 and -6.5 kilobases

152 Inclusion of exon 4 requires an enhancer sequence located within the intron downstream o

153 ivators of sigma54-holoenzyme generally bind enhancer sequences located >70 bp upstream of the promot

154 cularly robust and was refined to a discrete enhancer sequence lying between nt -2832 and -2462 from

155 cleotides in length including novel splicing enhancer sequence motifs.

156 egion of this gene identified two functional enhancer sequences; namely an Sp1(N)23estrogen-responsiv

157 Mutagenesis of the enhancer sequence of the glnAp2 promoter produced varian

158 NGF expression is controlled by promoter and enhancer sequences of a keratin gene, thus restricting t

159 ers are cis linked to homologous-region (hr) enhancer sequences of AcMNPV.

160 The LTR enhancer sequences of FeLV contain identical binding sit

161 ats (LTRs), which often contain promoter and enhancer sequences of intact endogenous retroviruses (ER

162 ment has become subject to regulation by eye enhancer sequences of the eya gene, disrupting normal ex

163 W to test the hypothesis that the duplicated enhancer sequences of this virus have a sequence-specifi

164 itutions were introduced into the chimpanzee enhancer sequence or reverted in the human enhancer to t

165 However, trypanosomes lack classical enhancer sequences or regulated transcription initiation

166 undertaking detailed mutational analyses of enhancer sequences, or those who wish to avoid the diffi

167 activity of enhancers and understanding how enhancer sequences organize gene expression in the brain

168 ruses is dependent on the duplication of the enhancer sequences present in the unique 3' (U3) region

169 tually resumed, showing that the presence of enhancer sequences, rather than either their exact topol

170 enzymes and antioxidant proteins through an enhancer sequence referred to as the antioxidant-respons

171 an identified Mef2 enhancer, and we identify enhancer sequences required for up-regulation.

172 Ultraconserved enhancer sequences show perfect conservation between hum

173 ft assays confirm that PAX-FKHR bind to core enhancer sequences showing similarity to consensus PAX3/

174 Deletion of the kappaB enhancer sequence significantly reduced BK-induced chlor

175 y quantifying the activities of thousands of enhancer sequences simultaneously, has seen limited stan

176 ed immunoglobulin mu gene is dependent on an enhancer sequence situated within one of the introns of

177 sembles onto the most conserved core of this enhancer sequence specifically in neuronal WERI-1 cell e

178 agents thus far tested is mediated by two 5'-enhancer sequences, SX2 and AB1, but neither fragment wa

179 ate that ESS1 is juxtaposed to a purine-rich enhancer sequence that activates the use of the 5'ss of

180 oxidant response element (ARE), a cis-acting enhancer sequence that binds Nrf2.

181 he SF2/ASF protein to a purine-rich splicing enhancer sequence that is located in the 3' exon of M1 m

182 tions in retinal explants mapped an intronic enhancer sequence that mediated NRL-directed Reep6.1 exp

183 proximal sequences and not on the cis-acting enhancer sequences that bind the aryl hydrocarbon recept

184 The Smad7 promoter contains functional enhancer sequences that bind transcription factors SMAD3

185 ticularly beneficial in the analysis of exon enhancer sequences that function in exon recognition dur

186 udies reported here, we show that additional enhancer sequences that lie outside of the core region a

187 ory specificity of predicted exonic splicing enhancer sequences that may control splicing regulation.

188 about the genomic context of this gene or of enhancer sequences that may direct its diverse functions

189 ease risk that may result from disruption of enhancer sequences that normally act in cis to increase

190 dentification and characterization of the 3' enhancer sequences that play important roles in this syn

191 t anneal to the exon and contain a 'tail' of enhancer sequences that recruit activating proteins.

192 ified ornithine decarboxylase (ODC) promoter/enhancer sequences that up-regulate target protein expre

193 ar, albeit more complex, principles relating enhancer sequence to gene expression.

194 es may identify unifying principles relating enhancer sequence to gene expression.

195 However, the molecular details that link enhancer sequence to TF binding, promoter state and tran

196 Lens nuclear proteins bind the enhancer sequences to form several specific complexes, s

197 he intron, and movement of putative intronic enhancer sequences to multiple promoter-proximal sites a

198 ining Myb-binding elements in their promoter/enhancer sequences, to determine whether the phenotypic

199 LAT exon 1 (containing LAT enhancer sequences), together with the LAT promoter regi

200 in craniofacial development and suggest that enhancer sequence variation contributes to the diversity

201 gineering; expression from a mouse PV+ SNAIL enhancer sequence was enriched in PV+ neurons of the mac

202 Finally, the 115-bp enhancer sequence was shown to be able to activate trans

203 rter construct containing IL-1 beta promoter/enhancer sequences was introduced into MM6.

204 In the second virus, only one copy of the enhancer sequences was present.

205 Furthermore, GR and SLUG occupancy of ICP4 enhancer sequences was reduced in the E-Box mutant.

206 to - 105, encompassing two identical 8-bp DR enhancer sequences, was necessary for CROC-1-mediated tr

207 usage in the clone 9-60 LCL, in which the W enhancer sequences were deleted upstream of Wp1, reveale

208 Cabp5 promoter sequence, and a 164 bp Chx10 enhancer sequence, were defined, each driving reporter e

209 Tf1 integration, suggesting a synergy of Tf1 enhancer sequence with the stress response elements of t

210 anscription of reporter genes containing EPO enhancer sequences with intact, but not mutant, HIF-1 bi

211 d by the interaction of Nkx6.1 with a 139 bp enhancer sequence within CR2.

212 We have identified an enhancer sequence within the PTP1B promoter which serves

213 We have also identified a G-rich intronic enhancer sequence within the small intron that is essent

214 Enhancer sequences within a 40 kb upstream fragment dire

215 Transcriptional enhancer sequences within the long terminal repeats (LTR

216 Transcriptional enhancer sequences within the long terminal repeats (LTR