ライフサイエンスコーパス: enteric

1 g ostomy to isolate the wound from the debit enteric.

2 porcine deltacoronavirus (PDCoV), and swine enteric alphacoronavirus (SeACoV).

3 Stricture of pancreatic-enteric anastomoses is a major late complication of a pa

4 emporary stent placement to treat pancreatic-enteric anastomoses, but further investigations are requ

5 tivity and inflammation around the pancreato-enteric anastomosis on post operative day 1 are associat

6 h a molecular pathway by which EECs regulate enteric and vagal neuronal pathways in response to micro

7 nicians have limited therapeutic options for enteric as a result of increasing antimicrobial resistan

8 Enteric-associated neurons (EANs) are closely associated

9 We found that intrinsic enteric-associated neurons (iEANs) in mice are functiona

10 racterize the influence of the microbiota on enteric-associated neurons by combining gnotobiotic mous

11 d antigen passages (GAPs), which translocate enteric bacteria across the intestinal epithelium.

12 Different strategies are needed to reduce enteric bacteria and parasites at this critical young ag

13 Enteric bacteria and/or their products are necessary for

14 As other enteric bacteria contain CpxA, this signal exploitation

15 the distribution of antimicrobial-resistant enteric bacteria from three ethnic groups in Tanzania.

16 function of reducing horizontal transfer of enteric bacteria in poultry.

17 Some enteric bacteria including Salmonella have evolved the p

18 e and utilize pseudocobalamin contrasts with enteric bacteria like Salmonella.

19 ver the 2-week period; however, detection of enteric bacteria was variable if specimens were not refr

20 These metabolic transitions, common for enteric bacteria, are often accompanied by multi-hour la

21 e genomes from prophages embedded in diverse enteric bacteria, we produced gokushoviruses in an exper

22 ent a potential therapeutic intervention for enteric bacteria.

23 ixation in cyanobacteria and the survival of enteric bacteria.

24 Campylobacter jejuni is a leading cause of enteric bacterial illness in the United States.

25 Recovery from enteric bacterial illness often includes a phase of orga

26 sms and effects of this communication during enteric bacterial infection are only beginning to be cha

27 species are among the most common causes of enteric bacterial infections worldwide.

28 microbes can thwart gut colonization by the enteric bacterial pathogen Citrobacter rodentium by cons

29 he orchestration of host immune responses to enteric bacterial pathogens is a complex process involvi

30 (FDA) approved for transport and culture of enteric bacterial pathogens, the FecalSwab has not been

31 We now demonstrate that enteric CDNF immunoreactivity is restricted to neurons (

32 ats), which is due largely to the absence of enteric CH(4) in aquaculture, combined with the high fer

33 wder of zwitterionic micelle insulin into an enteric-coated capsule.

34 d may contribute to the pathology of certain enteric conditions.

35 Twenty-seven required enteric conversion; 11 patients experienced renal allogr

36 Using an infectious clone of an enteric CoV, porcine epidemic diarrhea virus (icPEDV), w

37 we exploited a reverse genetic system for an enteric CoV, porcine epidemic diarrhea virus (PEDV), and

38 tes that prevent disease and fecal spread of enteric CoVs, including SARS-CoV-2.

39 te vaccines to prevent disease and spread of enteric CoVs, including SARS-CoV-2.IMPORTANCE Emerging c

40 ycles albumin and is the portal of entry for enteric cytopathic human orphan (echo) virus infection.

41 In the third patient, enteric derivation was not possible because of the extre

42 Typhoid fever is an enteric disease caused by the pathogens Salmonella Typhi

43 viral factors that contribute to developing enteric disease remains elusive.

44 ral immunogen candidate in the fight against enteric diseases.

45 l for the normal development and survival of enteric dopaminergic neurons; thus, expression of the do

46 Environmental enteric dysfunction (EED) is an enigmatic disorder of th

47 al interventions would improve environmental enteric dysfunction (EED), a potential contributor to st

48 y was to estimate the cost of illness due to enteric fever (typhoid and paratyphoid) at selected site

49 udy was to estimate the cost of illness from enteric fever (typhoid and paratyphoid) at selected site

50 y to assess the economic burden of pediatric enteric fever (typhoid and paratyphoid) in Bangladesh.

51 ated a high burden of hospitalization due to enteric fever among children aged <5 years in Bangladesh

52 oth reported symptoms and clinical signs, of enteric fever among patients participating in the Survei

53 thening the existing surveillance system for enteric fever and antimicrobial resistance at the nation

54 artments at 2 study hospitals with suspected enteric fever and performed blood cultures.

55 n Asia Project (SEAP) to assess incidence of enteric fever at 6 study hospitals in 3 countries.

56 We report the burden of enteric fever at selected sites of Karachi, Pakistan.

57 Enteric fever can impose a considerable economic burden

58 Enteric fever can impose a considerable economic burden

59 hese new estimates of the cost of illness of enteric fever can improve evaluation and modeling of the

60 Enteric fever can lead to prolonged hospital stays, clin

61 laboratory data from blood culture-confirmed enteric fever cases enrolled in SEAP hospitals and assoc

62 Of the 8705 blood culture-confirmed enteric fever cases enrolled, we identified 6 deaths (ca

63 We screened suspected enteric fever cases from 6 hospitals in Bangladesh, Nepa

64 Enteric fever cases have increased during the last 3 yea

65 timicrobial resistance (AMR) among confirmed enteric fever cases in Bangladesh, Nepal, and Pakistan.

66 through June 2019, 2243 laboratory-confirmed enteric fever cases were detected in 2 study hospitals;

67 rovisional diagnoses, but 31% (1147/3754) of enteric fever cases were not covered by initial therapy;

68 e or histopathology confirmed total 15 (11%) enteric fever cases with ileal perforation are similar t

69 ere obtained from all suspected or confirmed enteric fever cases.

70 We enrolled 8,705 blood culture confirmed enteric fever cases: 4,873 (56%) from Bangladesh, 1,602

71 creened 30 809 outpatients resulting in 1819 enteric fever cases; 1935 additional cases were enrolled

72 Enteric fever causes substantial morbidity and mortality

73 highlight illness severity and the need for enteric fever control measures, including the use of typ

74 These new estimates of enteric fever cost of illness can improve evaluation and

75 ther explored with the aim of creating a new enteric fever diagnostic to work in conjunction with TCV

76 We need a sustained effort within the enteric fever field to accelerate, validate, and ultimat

77 ver and inpatients with clinically suspected enteric fever from all 6 SEAP study hospitals were eligi

78 curately distinguish blood culture-confirmed enteric fever from other febrile syndromes.

79 ls in Nepal to estimate the cost per case of enteric fever from the perspectives of patients, caregiv

80 The health care-adjusted incidence of enteric fever hospitalization among children <15 years o

81 roject (SEAP) data to estimate the burden of enteric fever hospitalization among children aged <15 ye

82 Salmonella Typhi contributed most to the enteric fever hospitalization incidence (277/100 000 chi

83 Factors independently associated with enteric fever hospitalization included fever duration, d

84 timate the health care-adjusted incidence of enteric fever hospitalization, and conducted univariable

85 performed population-based surveillance for enteric fever in 1 urban catchment (Kathmandu) and 1 per

86 m vaccine introduction, the Surveillance for Enteric Fever in Asia Project (SEAP) conducts prospectiv

87 Here, we analyzed Surveillance for Enteric Fever in Asia Project (SEAP) data to estimate th

88 4 hospitals as part of the Surveillance for Enteric Fever in Asia Project (SEAP) II in Pakistan.

89 text of the population-based Surveillance of Enteric Fever in Asia Project (SEAP) in Bangladesh, Nepa

90 The Surveillance for Enteric Fever in Asia Project (SEAP) is a multicenter, m

91 The Surveillance for Enteric Fever in Asia Project (SEAP) is a prospective st

92 used a hybrid model in the Surveillance for Enteric Fever in Asia Project (SEAP) to assess incidence

93 tients participating in the Surveillance for Enteric Fever in Asia Project (SEAP), a 3-year surveilla

94 The Surveillance for Enteric Fever in Asia Project (SEAP), a prospective surv

95 As a part of the Surveillance for Enteric Fever in Asia Project (SEAP), we investigated th

96 repalanchok) as part of the Surveillance for Enteric Fever in Asia Project (SEAP).

97 ization survey used for the Surveillance for Enteric Fever in Asia Project in Nepal, we incorporated

98 results show substantial economic burden of enteric fever in Bangladesh, with higher costs for patie

99 is critical for generating population-based enteric fever incidence estimates from facility-based su

100 sia Project (SEAP) is a prospective study of enteric fever incidence in Nepal, Bangladesh, and Pakist

101 d be incorporated into estimation models for enteric fever incidence.

102 eneity in febrile illness, care seeking, and enteric fever incidence.

103 , nonmedical, and indirect costs per case of enteric fever incurred since illness onset by phone afte

104 Enteric fever is endemic in Nepal and its economic burde

105 The elimination of enteric fever is now becoming a real possibility, but ne

106 r 1029 patients with blood culture-confirmed enteric fever or with a nontraumatic terminal ileal perf

107 l studies characterizing the transmission of enteric fever organisms through sewage and water, discus

108 vironmental sampling for the surveillance of enteric fever organisms to provide data on community-lev

109 areas were based on residential addresses of enteric fever patients using study facilities; clusters

110 on and modeling of the costs and benefits of enteric fever prevention and control measures, including

111 Enteric fever remains a major cause of morbidity in deve

112 Enteric fever remains a public health concern in communi

113 thcare seeking for acute febrile illness and enteric fever risk in these communities, and should be i

114 in Asia Project (SEAP) conducts prospective enteric fever surveillance in Bangladesh, Nepal, and Pak

115 inferior to each other for culture-confirmed enteric fever treatment.

116 Enteric fever, a bacterial infection caused by Salmonell

117 ices of resources used to diagnose and treat enteric fever, and procedure frequencies received at the

118 veillance study, characterized the burden of enteric fever, including illness severity, in selected s

119 reduce the sensitivity of blood culture for enteric fever, with implications for both clinical care

120 on and modeling of the costs and benefits of enteric fever-prevention measures.

121 can inform public health policies to prevent enteric fever.

122 tures and less relapses in culture-confirmed enteric fever.

123 and obtained blood cultures to evaluate for enteric fever.

124 a that can inform public health responses to enteric fever.

125 patients enrolled were culture-positive for enteric fever.

126 her suspected or blood culture confirmed for enteric fever.

127 highly recommended to prevent the spread of enteric fever.

128 terize disease incidence among patients with enteric fever.

129 We enrolled 2939 patients with suspected enteric fever.

130 njugate vaccine as a preventive tool against enteric fever.

131 pitals and determinants of culture-confirmed enteric fever.

132 inst widespread morbidity and mortality from enteric fever.

133 ct medical economic costs to treat a case of enteric fever.

134 ct medical economic costs to treat a case of enteric fever.

135 n areas, alongside other measures to prevent enteric fever.

136 ehavior in individuals with recent suspected enteric fever.

137 riably predictive of blood culture-confirmed enteric fever.

138 arm); 87 (26.7%) had blood culture-confirmed enteric fever.

139 more likely to be blood culture positive for enteric fever; however, the effect was not statistically

140 isease was used to show distal colon without enteric ganglia, as well as a transition zone and proxim

141 observed in the dorsal root, autonomic, and enteric ganglia.

142 late activity in non-neuronal cells (such as enteric glia and innate immune cells).

143 e activation and neuronal differentiation of enteric glia are regulated by Notch signalling.

144 morphological characteristics with mammalian enteric glia but cannot be identified by the expression

145 S further suggests that neural crest-derived enteric glia might have evolved after the teleost lineag

146 at a relatively high proportion of zebrafish enteric glia proliferate under physiological conditions

147 nt study was designed to examine the role of enteric glial cells (EGCs) in colonic neuromuscular dysf

148 promotes IEC REG3gamma expression to inhibit enteric infection and intestinal inflammation, thus, mai

149 chidonoyl glycerol (2-AG) are protected from enteric infection by Enterobacteriaceae pathogens.

150 t correlate with its expression level and to enteric infection susceptibility.

151 ng one common non-coding variant that lowers enteric infection susceptibility.

152 hat STING(-/-) mice were more susceptible to enteric infection with Citrobacter rodentium compared to

153 The best described risk factor is acute enteric infection, but irritable bowel syndrome is also

154 hes are needed to detect, treat, and prevent enteric infections in MSM.

155 ain and inflammation; however, their role in enteric infections is unclear.

156 tery and Clostridioides difficile colitis as enteric infections profoundly influenced by the microbio

157 3, 626-633 (2013)], how they are impacted by enteric infections remains poorly defined.

158 grated to regulate protective adaptations to enteric infections while maintaining tissue homeostasis.

159 e at increased risk for sexually transmitted enteric infections, including globally distributed strai

160 Using murine models of enteric infections, we observed long-term gastrointestin

161 ation, and clean play space) did not prevent enteric infections.

162 ive disorder, graft-versus-host disease, and enteric infections.

163 complications were pneumonia (12%), esophago-enteric leak from anastomosis, staple line or localized

164 complications were pneumonia (21%), esophago-enteric leak from anastomosis, staple line or localized

165 es that patients with PSC harbor an abnormal enteric microbiome.

166 tics, ostensibly through manipulation of the enteric microbiota.

167 f EGCs and is involved in the development of enteric motor disorders through an increase in tachykini

168 euroeffector junction in the gut consists of enteric motor neurons and SIP syncytium, including smoot

169 Using the enteric mouse pathogen, C. rodentium, we demonstrate tha

170 The Global Enteric Multicenter Study (GEMS) was a 3-year case-contr

171 Using data from the Global Enteric Multicenter Study, we assessed whether acute mal

172 We found that enteric NCC express LAMR, which is downregulated in huma

173 The enteric NEJ consists of enteric neurons and postjunction

174 ow chest, and shortening of long bones), and enteric nervous system (aganglionosis).

175 We developed a technique to image human enteric nervous system (ENS) and other intramural cells

176 The enteric nervous system (ENS) coordinates diverse functio

177 The enteric nervous system (ENS) coordinates essential intes

178 Enteric nervous system (ENS) development is governed by

179 The enteric nervous system (ENS) exists in close proximity t

180 lation of two main human tau isoforms in the enteric nervous system (ENS) in CD but not in UC.

181 The enteric nervous system (ENS) is a complex network consti

182 The enteric nervous system (ENS) is essential for normal gas

183 ce and identity of neural progenitors in the enteric nervous system (ENS) of vertebrates is a matter

184 complex equilibrium, here, we show that the enteric nervous system (ENS) plays an essential and non-

185 e leads to degeneration and autophagy in the enteric nervous system (ENS), particularly in the submuc

186 l derived neurotrophic factor (GDNF) induces enteric nervous system regeneration in mouse models of H

187 nal progenitors capable of reconstituting an enteric nervous system when transplanted into a normal d

188 al deficits and physiological changes to the enteric nervous system.

189 ant inhibitory motor neurotransmitter in the enteric nervous system.

190 CDNF is expressed selectively in isolated enteric neural crest-derived cells (ENCDC), which also e

191 efect in which the distal colon is devoid of enteric neural ganglia.

192 Nestin-positive enteric neural precursor cells expressed TLR2 and TLR4.

193 d the percentage of neurons originating from enteric neural precursor cells to approximately 10%, com

194 ovide new mechanistic insights into how this enteric neuro-immune crosstalk may occur.

195 T(4) receptor agonist prucalopride increases enteric neurogenesis in normal development and after inj

196 ident progenitors in the gut, post-embryonic enteric neurogenesis occurs via gut-extrinsic Schwann ce

197 GDNF prolonged survival, induced enteric neurogenesis, and improved colon structure and f

198 flicting evidence exists regarding postnatal enteric neurogenesis.

199 ing and single-cell sequencing revealed that enteric neuronal IL-18 is specifically required for home

200 e tumors induced by GDNF stimulation contain enteric neuronal progenitors capable of reconstituting a

201 ions through the concerted action of diverse enteric neurons (ENs).

202 Strikingly, deletion of IL-18 from the enteric neurons alone, but not immune or epithelial cell

203 ucing production of endogenous GDNF, and new enteric neurons and glia appeared to arise from Schwann

204 control subjects, in primary cultures of rat enteric neurons and in nuclear factor erythroid 2-relate

205 include dopaminergic neurons) but also with enteric neurons and oligodendrocytes.

206 The enteric NEJ consists of enteric neurons and postjunctional cells of the SIP sync

207 cible Sox10-Cre suggests that post-embryonic enteric neurons arise from trunk neural crest-derived Sc

208 , our experiments identify AHR signalling in enteric neurons as a regulatory node that integrates the

209 al sensory ganglia and activates cholinergic enteric neurons by secreting the neurotransmitter 5-hydr

210 Although the embryonic origin of enteric neurons from the neural crest is well establishe

211 Here, by examining the diversity of enteric neurons in Drosophila melanogaster, we identify

212 The plasticity of enteric neurons is therefore key to reproductive success

213 Finally, expression of Ahr in the enteric neurons of mice treated with antibiotics partial

214 nd preventing the post-mating remodelling of enteric neurons reduces both reproductive hyperphagia an

215 onsumption rapidly activates a population of enteric neurons that express vasoactive intestinal pepti

216 Using nuclear RNA sequencing of mouse enteric neurons that represent distinct intestinal segme

217 Does it also depend on enteric neurons that sense mechanical cues to signal ful

218 skets in mouse colon are formed by intrinsic enteric neurons with a neurochemical profile consistent

219 We highlight circadian expression changes in enteric neurons, show that disease-related genes are dys

220 IL-33-mediated 5-HT release activated enteric neurons, subsequently promoting gut motility.

221 ving rise to progeny that differentiate into enteric neurons.

222 little is known about their effects on adult enteric neurons.

223 tor of ion secretion classically produced by enteric neurons.

224 pig to mouse, a species increasingly used in enteric neuroscience.

225 The enteric neurotransmitter acetylcholine governs important

226 type, where the pathology originates in the enteric or peripheral autonomic nervous system and then

227 involving antibiotic-resistant organisms and enteric outbreaks, as well as those where healthcare wor

228 Slc26a6-mediated enteric oxalate secretion is critical in decreasing the

229 BD Max system using the viral and bacterial enteric panels (BD Diagnostics, Baltimore, MD, USA).

230 verall, we showed that B. pseudomallei is an enteric pathogen and that type 1 fimbria is important fo

231 sing a high-density transposon screen in the enteric pathogen Citrobacter rodentium, we find that the

232 ce IgG are protected from infection with the enteric pathogen enterotoxigenic Escherichia coli by mat

233 ude by recommending strategies for advancing enteric pathogen exposure assessments.

234 and emerging approaches used to characterize enteric pathogen hazards in different environmental medi

235 They are the most common enteric pathogen of cats and dogs in developed countries

236 and blocks actin-driven dissemination of the enteric pathogen Shigella.

237 Our results uncover a mechanism by which an enteric pathogen subverts repair processes by targeting

238 discovery of novel therapeutics against this enteric pathogen.

239 New approaches are needed to understand enteric pathogenesis and to develop vaccines and therape

240 rferon antagonists for their contribution to enteric pathogenesis.

241 ssential for 1,2-propanediol degradation and enteric pathogenesis.

242 diarrhoea, and whether associations between enteric pathogens and death were modified by acute malnu

243 e malnutrition modified associations between enteric pathogens and moderate-to-severe diarrhoea in co

244 tion modifies the association between common enteric pathogens and moderate-to-severe diarrhoea, and

245 Diarrheal illnesses from enteric pathogens are a leading cause of death in childr

246 ew methods that measure human infection with enteric pathogens as a proxy for past exposure (internal

247 DSFs repressed virulence gene expression of enteric pathogens by interacting with transcriptional re

248 Enteric pathogens exploit chemical and nutrient signalin

249 Infections with enteric pathogens impose a heavy disease burden, especia

250 cal indicators to signify a health risk from enteric pathogens in sewage-impacted waters.

251 anitation is one way to reduce the spread of enteric pathogens in the environment; however, few studi

252 Resistance to enteric pathogens is a complex trait at the crossroads o

253 Successful colonization by enteric pathogens is contingent upon effective interacti

254 These data argue that enteric pathogens respond to DSFs as interspecies signal

255 acids repress the virulence of the important enteric pathogens Salmonella enterica and Vibrio cholera

256 ion could facilitate the ability of specific enteric pathogens to cause diarrhoea and associated mort

257 seudomonas, Enterobacter (ESKAPE), and other enteric pathogens to resist bile and how these interacti

258 portion of lipopolysaccharide (LPS) for the enteric pathogens Yersinia pseudotuberculosis (Ypt) and

259 d of antibiotic resistance genes among human enteric pathogens(1-3).

260 the relationship between the microbiota and enteric pathogens, as well as disease outcomes.

261 Although commensal organisms promote health, enteric pathogens, including a diverse plethora of enter

262 epithelia by both the normal microbiota and enteric pathogens.

263 (MSM) are at risk for sexual transmission of enteric pathogens.

264 infections, and affects a broad spectrum of enteric pathogens.

265 tor neurons in sensing and defending against enteric pathogens.

266 uld be exploited to control the virulence of enteric pathogens.

267 ternative to bulk stool for the diagnosis of enteric pathogens.

268 hods for assessing environmental exposure to enteric pathogens.

269 nment, which profoundly impacts virulence of enteric pathogens.

270 nal and uropathogenic pathotypes outnumbered enteric pathotypes (41% vs 14%), yet the latter correlat

271 Yersinia ruckeri causes enteric redmouth disease (ERM) that mainly affects salmo

272 r UV(254) susceptibility compared with other enteric single-stranded RNA viruses (e.g., Echovirus 12,

273 ct various organs, including respiratory and enteric systems, as exemplified by newly emerged severe

274 Enteric (typhoid) fever remains a problem in low- and mi

275 elative impact and cost-effectiveness of new enteric vaccines.

276 t is important to support the development of enteric vaccines.

277 nfection influences immune responses to oral enteric vaccines.

278 The potential role of enteric viral infections and the developing infant virom

279 ruption of intestinal homeostasis.IMPORTANCE Enteric viral infections are a major cause of gastroente

280 fundamental roles in immune defenses against enteric viral infections by integrating diverse signals,

281 They further define a mechanism by which an enteric virus can regulate the mucus barrier, induce fun

282 s the uptake of the bacteriophage T4 and the enteric virus echovirus 11 when exposed to the filter fe

283 the intestinal microbiota enhances mammalian enteric virus infections(1).

284 ce data from the US National Respiratory and Enteric Virus Surveillance System and the Centers for Di

285 many of its related viruses, may also be an enteric virus that can spread via the fecal-oral route.

286 his study provides a deeper understanding of enteric virus-bacterial glycan interactions, which are i

287 regionally impacts infection by a pathogenic enteric virus.

288 c between dissemination and clearance for an enteric virus.IMPORTANCE Enteric viruses initiate infect

289 with the concentrations of all tested human enteric viruses (p <0.05), suggesting the applicability

290 to the three indicator viruses, eight human enteric viruses [human adenoviruses, JC and BK polyomavi

291 mental stability and transmission.IMPORTANCE Enteric viruses are transmitted through the fecal-oral r

292 TMV) as indicators of the reduction of human enteric viruses during wastewater treatment.

293 WSH interventions were associated with fewer enteric viruses in children aged 14 months.

294 ator to estimate the concentrations of human enteric viruses in raw sewage.

295 Enteric viruses infect the gastrointestinal tract, and b

296 nd clearance for an enteric virus.IMPORTANCE Enteric viruses initiate infection in the gastrointestin

297 mitted through the fecal-oral route, but how enteric viruses survive in the environment is unclear.

298 ural immunity was generally stronger for the enteric viruses than bacteria, potentially due to less a

299 c pathogens, including a diverse plethora of enteric viruses, cause acute and chronic diseases.

300 mote replication and transmission of several enteric viruses.