ライフサイエンスコーパス: enterochromaffin

1 , crypt perimeter, and relative densities of enterochromaffin and enteroendocrine cells in small inte

2 xpressed by most epithelial cells, including enterochromaffin and goblet cells.

3 r persistent changes in mucosal immunocytes, enterochromaffin and mast cells, enteric nerves, and the

4 s in other inflammatory components including enterochromaffin and mast cells.

5 cts as an in vivo sensor for shear forces in enterochromaffin and Paneth cells of the small intestine

6 of serotonin signaling in a newly developed enterochromaffin cell (ECC)-enriched gut organoid model.

7 e populations, and identify Lmx1a as a novel enterochromaffin cell marker that is also essential for

8 human carcinoid BON cells, an in vitro human enterochromaffin cell model, to understand the mechanism

9 The enterochromaffin cell population was decreased in severe

10 er RNA, encoding the rate-limiting enzyme in enterochromaffin cell serotonin (5-hydroxytryptamine [5H

11 Paracrine signaling by enterochromaffin cells (EC), which release 5-HT, has not

12 re IECs that we identified to be a subset of enterochromaffin cells (ECC).

13 Serotonin production by enterochromaffin cells (ECs) is microbiota-dependent, bu

14 biota promote 5-HT biosynthesis from colonic enterochromaffin cells (ECs), which supply 5-HT to the m

15 onstrated that 5-HT released from intestinal enterochromaffin cells activates 5-HT3 receptors on vaga

16 5-Hydroxytryptamine (5-HT) released from enterochromaffin cells activates secretory and peristalt

17 5-Hydroxytryptamine (5-HT) is released from enterochromaffin cells and activates neural reflex progr

18 e of 5-hydroxytryptamine (5-HT) from mucosal enterochromaffin cells and activation of 5-HT(3) recepto

19 e transcription factor Lmx1a is expressed in enterochromaffin cells and functions downstream of Nkx2.

20 Serotonin is also released from enterochromaffin cells and inflammatory/immune cells to

21 sis, consistent with localization of TGR5 to enterochromaffin cells and intrinsic primary afferent ne

22 med FFA2 and FFA3, are expressed in duodenal enterochromaffin cells and L cells, respectively.

23 vious results showing guanylin expression in enterochromaffin cells appear to be a consequence of ant

24 These findings imply a role for enterochromaffin cells as "glucose sensors" during inges

25 Gut enterochromaffin cells can be converted to insulin-produ

26 We show that the number of mucosal enterochromaffin cells containing 5-HT changes with the

27 tion to neurons, a subset of 5-HT-containing enterochromaffin cells expressed 5-HT1A immunoreactivity

28 Mucosal enterochromaffin cells have been postulated to be pressu

29 iven by ammoniagenesis in the gut, sensed by enterochromaffin cells in a TRPA1-dependent fashion and

30 onsistent with the hypothesis that 5-HT from enterochromaffin cells in response to mucosal stimuli in

31 neurons were activated by 5-HT release from enterochromaffin cells in the mucosa.

32 5-HT released from enterochromaffin cells initiates peristaltic, secretory,

33 Expression of uroguanylin in enterochromaffin cells is consistent with the hypothesis

34 5HT produced by enterochromaffin cells is critical in motility and secre

35 g kg-1) indicating that endogenous 5-HT from enterochromaffin cells is not essential for transduction

36 imiting biosynthetic enzyme for serotonin in enterochromaffin cells of the duodenum.

37 the central nervous system (CNS) as well as enterochromaffin cells of the gastrointestinal tract.

38 a decrease in the synthesis of serotonin by enterochromaffin cells of the gut.

39 Factors that control secretion of 5-HT from enterochromaffin cells or BON cells are important as par

40 , it is unclear whether they act directly on enterochromaffin cells or indirectly through an intermed

41 phils, platelets, histaminergic neurons, and enterochromaffin cells produce varying amounts of histam

42 Most RET(+) epithelial cells were either enterochromaffin cells that release serotonin or L-cells

43 mulated serotonin biosynthesis in intestinal enterochromaffin cells via a mechanism involving activat

44 kx2.2 mutant conditions, serotonin-producing enterochromaffin cells were the most severely reduced en

45 of the cells expressed SOX9 (duct), SLC18A1 (enterochromaffin cells), and CDX2 (gut cells), respectiv

46 icate goblet cells, whereas others implicate enterochromaffin cells).

47 ivity was abundant in both enteric plexuses, enterochromaffin cells, and pancreatic ganglia.

48 release serotonin (5-hydroxytryptamine) from enterochromaffin cells, and stretch reflexes that determ

49 ceptor OR51E1 was notably expressed in ileal enterochromaffin cells, and the glucose-sensing sodium g

50 le cells in the gut, including immune cells, enterochromaffin cells, gut microbiota and the derived l

51 erotonin (5-HT), which abounds in intestinal enterochromaffin cells, is released in response to vario

52 athematical modeling, we show that, in human enterochromaffin cells, Myrip (1) inhibits a class of SG

53 eptor FFAR2 was highest in ileal L-cells and enterochromaffin cells, olfactory receptor OR51E1 was no

54 Human BON cells, derived from enterochromaffin cells, were treated with D-glucose, gal

55 release of endogenous 5-HT from the mucosal enterochromaffin cells, which acts on the 5-HT3 receptor

56 is both necessary and sufficient to generate enterochromaffin cells.

57 e adult stage in a subset of enteroendocrine/enterochromaffin cells.

58 isthmus cells and uncover a role for Sox2 in enterochromaffin cells.

59 ses and an unexpected close association with enterochromaffin cells.

60 viously unreported population that resembles enterochromaffin cells.

61 by 5-hydroxytryptamine (5-HT) released from enterochromaffin cells.

62 g cells are identified as a subpopulation of enterochromaffin cells.

63 in neuroendocrine, including chromaffin and enterochromaffin, cells.

64 sults suggest that mechanical stimulation of enterochromaffin-derived BON cells directly or indirectl

65 ntiation toward secretory lineages including enterochromaffin (EC) and Paneth cells, leading to EC hy

66 (TET2) protected against colitis by limiting enterochromaffin (EC) cell differentiation and subsequen

67 The enterochromaffin (EC) cell in the gastrointestinal (GI)

68 ABSTRACT: The enterochromaffin (EC) cell in the gastrointestinal (GI)

69 Enterochromaffin (EC) cell numbers (cells producing 5-HT

70 KEY POINTS: The gastrointestinal epithelial enterochromaffin (EC) cell synthesizes the vast majority

71 The gastrointestinal epithelial enterochromaffin (EC) cell synthesizes the vast majority

72 The gut contains a large 5-HT pool in enterochromaffin (EC) cells and a smaller 5-HT pool in t

73 Enterochromaffin (EC) cells are a subtype of EE cells th

74 In the gastrointestinal (GI) epithelium, enterochromaffin (EC) cells are enteroendocrine cells re

75 Serotonergic enterochromaffin (EC) cells are proposed to fulfill this

76 Enterochromaffin (EC) cells are sensors that detect chem

77 mine [5-HT]), which is primarily produced by enterochromaffin (EC) cells in the GI tract.

78 Enhanced signaling between enterochromaffin (EC) cells in the gut epithelium and mu

79 Enterochromaffin (EC) cells in the mucosal layer of the

80 , whereas the number of serotonin-expressing enterochromaffin (EC) cells is decreased dramatically.

81 esis that the secretion of 5-HT from mucosal enterochromaffin (EC) cells is essential for the manifes

82 Enterochromaffin (EC) cells located within the intestina

83 used by the secretion of serotonin (5-HT) by enterochromaffin (EC) cells of the mucosal epithelium.

84 ory system of the gut, in which serotonergic enterochromaffin (EC) cells play an important part(1,2).

85 hat 5-hydroxytryptamine (5-HT) released from enterochromaffin (EC) cells plays an important role in t

86 Enterochromaffin (EC) cells transduce both chemical and

87 Serotonin (5-HT), produced predominantly by enterochromaffin (EC) cells via tryptophan hydroxylase 1

88 invariant natural killer T (iNKT) cells with enterochromaffin (EC) cells, a subset of intestinal epit

89 Here, we focus on enterochromaffin (EC) cells, which are rare excitable, s

90 Enterochromaffin (EC) cells, which function as chemosens

91 It is a paracrine messenger utilized by enterochromaffin (EC) cells, which function as sensory t

92 ed to quantify the number of 5-HT-expressing enterochromaffin (EC) cells.

93 oendocrine tumors believed to originate from enterochromaffin (EC) cells.

94 s localized to subpopulations of G cells and enterochromaffin (EC) cells; neither was found in antral

95 eroendocrine cells (EECs) secrete serotonin (enterochromaffin [EC] cells) or specific peptide hormone

96 reotide was infused for 72 hours to suppress enterochromaffin-like (ECL) cell and gastrin cell functi

97 nderlie the pathogenesis of multiple gastric enterochromaffin-like (ECL) cell carcinoids.

98 etion by regulating basal and gastrin-driven enterochromaffin-like (ECL) cell histamine release.

99 Gastric carcinoids evolved from enterochromaffin-like (ECL) cell hyperplasia are usually

100 een three major gastric endocrine cells: the enterochromaffin-like (ECL) cell, the gastrin or G cell,

101 ut and mucosal proliferation may involve the enterochromaffin-like (ECL) cell.

102 d stimulates the secretion of histamine from enterochromaffin-like (ECL) cells and subsequently acid

103 PYY inhibits histamine release from isolated enterochromaffin-like (ECL) cells by stimulation of a se

104 to isolate enriched serotonin-secreting and enterochromaffin-like (ECL) cells from the stomach and t

105 ecretion and in vitro histamine release from enterochromaffin-like (ECL) cells in responses to tumor

106 and II) involve the transformation of naive enterochromaffin-like (ECL) cells to the neoplastic stat

107 rinemia-induced neoplastic transformation of enterochromaffin-like (ECL) cells to tumor status.

108 ucing parietal cells and histamine-secreting enterochromaffin-like (ECL) cells, and the expression of

109 Gastrin, from G-cells, and histamine, from enterochromaffin-like (ECL) cells, are two of the hormon

110 PACAP receptors (PAC1) are found on gastric enterochromaffin-like (ECL) cells.

111 bits Ca2+ signaling and histamine release in enterochromaffin-like (ECL) cells.

112 which exerts a tonic restraint on parietal, enterochromaffin-like (ECL), and gastrin cells.

113 rboxylase, releasing histamine, and inducing enterochromaffin-like cell hypertrophy and hyperplasia.

114 , parietal and zymogenic, but not for pit or enterochromaffin-like cell lineages in the oxyntic gastr

115 INS-GAS mice showed no evidence of increased enterochromaffin-like cell number, but instead exhibited

116 ine transport into secretory vesicles of the enterochromaffin-like cell of the gastric corpus.

117 s, including the role of hypergastrinemia on enterochromaffin-like cell proliferation and its relatio

118 for VMAT2 in the transport of histamine into enterochromaffin-like cell secretory vesicles, and with

119 tic atrophy were sustained while chief cell, enterochromaffin-like cell, and somatostatin cell popula

120 zymes and an increase in histamine-secreting enterochromaffin-like cells (ECLs).

121 e, with a decrease in number of parietal and enterochromaffin-like cells and an increase in number of

122 hormone-like hormone in histamine-secreting enterochromaffin-like cells and hepcidin in acid-secreti

123 irculating gastrin leads to proliferation of enterochromaffin-like cells and to the development of ga

124 n, acting via cholecystokinin-2 receptors on enterochromaffin-like cells coupled to an increase in in

125 t the difference between beta cells and awry enterochromaffin-like cells is a gradient of cell states

126 MAT2 alone is expressed in histamine-storing enterochromaffin-like cells of the oxyntic mucosa of the

127 rstitial cells of Cajal of the intestine and enterochromaffin-like cells of the stomach.

128 All enterochromaffin-like cells respond to cholecystokinin-B

129 Histamine, released from enterochromaffin-like cells stimulates the parietal cell

130 the stomach of mutant animals, parietal and enterochromaffin-like cells were decreased, providing a

131 It is synthesized by gastric enterochromaffin-like cells, a specific set of hypothala

132 ance of the gastric mucosa, proliferation of enterochromaffin-like cells, and neoplastic transformati

133 ctivity was localized to the cell surface of enterochromaffin-like cells, and of myenteric and submuc

134 y regulating the secretion of histamine from enterochromaffin-like cells, gastrin from G cells, and s

135 ric neuroendocrine tumours (NETs) arise from enterochromaffin-like cells, which are located in oxynti

136 CDX2 emerged as a regulator of enterochromaffin-like cells, which we show resemble a tr

137 ndirectly by releasing histamine from fundic enterochromaffin-like cells.

138 th parietal cells and histamine release from enterochromaffin-like cells.

139 ts a tonic inhibitory influence on parietal, enterochromaffin-like, and gastrin cells.

140 per was to define physiological responses of enterochromaffin-like, gastrin, and somatostatin cells i

141 of the three major gastric endocrine cells (enterochromaffin-like, gastrin, and somatostatin).

142 al, mucous neck, and chief cells, but not to enterochromaffin-like-cell.

143 l root ganglion neurons from rats and in the enterochromaffin model cell line QGP-1, from which serot