ライフサイエンスコーパス: entry

1 in mediating viral attachment and host cell entry.

2 mic attack) or a further ICH following study entry.

3 intracellular indole during stationary phase entry.

4 antibody-opioid sequestering to block brain entry.

5 om the HIV-1 envelope membrane reduces virus entry.

6 lly mimics viral receptor in mediating viral entry.

7 V-1 gRNA lariats that form early after viral entry.

8 its dependence on target cell proteases for entry.

9 PS receptor-mediated efferocytosis and virus entry.

10 factors required for replication after viral entry.

11 oss of cyclin A in G2-phase prevents mitotic entry.

12 ty of life based on their characteristics at entry.

13 ic potential but only minimally affects cell entry.

14 proteins and the changes they undergo during entry.

15 rectly binds to Gag and mediates its nuclear entry.

16 g therapy and myocardial infarction at study entry.

17 ved in virions exposed to the low pH of cell entry.

18 ch recruits importin-beta to mediate nuclear entry.

19 vidual cells effectively from a single viral entry.

20 ates played a major role in regulating viral entry.

21 and non-BI strains of C. difficile at study entry.

22 n, which engages with host ACE2 receptor for entry.

23 E-2, DPP4, or CD13 receptors for docking and entry.

24 N) functions and retrograde transport in HSV entry.

25 (S) protein is the main determinant of viral entry.

26 ol withdrawal symptoms assessed at treatment entry.

27 iotensin-converting enzyme 2 (ACE2) for cell entry.

28 inhibitors with size, triggering cell-cycle entry.

29 or LT with HEHE were identified by free-text entry.

30 ike (S) protein for host cell attachment and entry.

31 eoblasts and are downregulated at mitotic re-entry.

32 he pH-dependent transitions involved in cell entry.

33 can elaboration also partially blocked viral entry.

34 in the G(2)-M phase and diminished upon G(1) entry.

35 d by herpes simplex virus 1 (HSV-1) for cell entry.

36 et of protein spectra with Protein Data Bank entries.

37 large predicted lipid database with 145,388 entries.

38 Among the two-badge entries, 123 595 were incomplete and 76 059 had readings

39 mears and 43% had cavitary disease; at study entry, 35% remained smear positive after a median MDR-TB

40 se Collection has been revised, updating 305 entries, adding 65 new resources and eliminating 125 dis

41 pike, mediates viral entry using pseudovirus entry and biochemical assays.

42 oichiometry, resulting in inhibition of Ca2+ entry and Ca2+-dependent gene expression.

43 reveals complex roles of antibodies in viral entry and can guide future vaccine design and antibody-b

44 f E-Syts in primary T cells decreased Ca(2+) entry and cytokine production.

45 and PS maximizes PS receptor-mediated virus entry and efferocytosis and underscore the important con

46 region of alpha-GA(1) is important for cell entry and efficacy.

47 in Cdk1 activity are permissive for mitotic entry and exit but that the changes in PP2A-B55 activity

48 rge-scale dataset which includes 3.5 billion entry and exit records of vehicles along highways genera

49 spleen, indicating the existence of separate entry and exit routes and that of a checkpoint located a

50 d mucosal lymphoid tissues with well-defined entry and exit routes, the movement of leukocytes in the

51 adly active glycomimetic inhibitors of viral entry and infection.

52 local data collection, and handles metadata entry and linkage of data.

53 ings advance our understanding of SARS-CoV-2 entry and may guide the development of vaccines and ther

54 , and Fc receptor ligation using pseudovirus entry and multiplexed Fc array assays, respectively.

55 potential to induce cardiomyocyte cell cycle entry and potentially cardiac tissue regeneration after

56 tion of stable microtubules soon after virus entry and promote early stages of infection.

57 stages of the cell cycle, suppresses S-phase entry and promotes progression into mitosis.

58 immediate reactivation at sites of pathogen entry and provide optimal protection of mucosal surfaces

59 l complex that controls mitochondrial Ca(2+) entry and regulates cell metabolism.

60 ing that these genes are essential for viral entry and regulation of V-type ATPase assembly.

61 utralizes virus in vitro by preventing virus entry and spread and is protective in vivo in mouse mode

62 vizumab and nirsevimab effectively inhibited entry and spread of RSV in HAE tissues, with nirsevimab

63 f TMPRSS2, a facilitator of SARS-CoV-2 viral entry and spread, among Asian, Black, Latino, and White

64 e lytic protein from the hexon cavity during entry and stepwise uncoating.

65 This triggers Lyn/Syk-dependent calcium entry and the production of reactive oxygen species, lea

66 inant of beta-cell glucose-stimulated Ca(2+) entry and thus the set-point of GSIS.

67 In vitro, HCMV entry and viral progeny are reduced in vimentin-deficien

68 Characterization of the events that underlie entry and waking from persistence may lead to lasting br

69 cholesterol sensing, how this relates to HCV entry, and CD81's function as a molecular scaffold; thes

70 lted in viable virus, but virus replication, entry, and stability were often impeded.

71 Entry ART varied by GBD region, with shifts during the t

72 tifunctional biodegradable nanoparticle (NP) entries as core components of nanoscale drug delivery sy

73 oV-2 spike using biochemical and pseudovirus entry assays.

74 of bio-containment, in serological and viral entry assays.

75 ial tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing dat

76 With this contribution, we aim to lower the entry barrier into the analytics of polyP, a molecule wi

77 p with little coding required, thus lowering entry barriers to new users.

78 Some crystals are suitable for screening for entry-blocking inhibitors.

79 the effects of drought- mortality on second-entry burn emissions and compared emissions for the firs

80 eatments, which contributed to higher second-entry burn emissions for two of the three burn treatment

81 compared emissions for the first- and second-entry burns.

82 invasion with rapid RBC lysis, or successful entry but developmental arrest.

83 f invariant chain CD74, which inhibits viral entry by blocking cathepsin-mediated processing of the E

84 F, cytotoxicity of CDT resulted from nuclear entry by Dox, promoting double-stranded DNA breaks and a

85 host factors that are required for cellular entry by hepatoviruses.

86 We hypothesize that entry by other enveloped viruses may also use sequential

87 ry, we show that loss of RAB7A reduces viral entry by sequestering the ACE2 receptor inside cells.

88 Thus, the spatial pattern of mitotic entry can differentially regulate tissue shape through s

89 However, hyperactive or expedited S phase entry causes replication stress, DNA damage and oncogene

90 NSP1 binds to 18S ribosomal RNA in the mRNA entry channel of the ribosome and leads to global inhibi

91 arly CRPC and should be included in the CRPC entry criteria of the European Association of Urology an

92 itions of low testosterone varied, and study entry criteria varied.

93 giving informed consent and fulfilling study entry criteria.

94 tudies indicate that DAF-2B influences dauer entry, dauer recovery and adult lifespan by altering ins

95 and propose a unified model for the S phase entry decision.

96 chanistically, HSV-1 replication after viral entry depended on AMPK but not on its function in autoph

97 some small-molecule inhibitors of filovirus entry destabilize EBOV GP and uncovered evidence that th

98 in HeLa cells leads to the delay of mitotic entry due to overaccumulation of negative regulators of

99 nistration-approved drugs that inhibit viral entry, endocytosis, genome assembly, translation, and re

100 effector proteins that facilitate Salmonella entry, establishment of an intracellular niche, and modu

101 tion and highlight the importance of the DNA entry-exit site in broadly maintaining the integrity of

102 pagation and provide obstacles to attract re-entry, facilitating the initiation of re-entrant circuit

103 mutant of I/LnJ CD300LF functional as an MNV entry factor.

104 oach correctly identified the distinct viral entry factors ACE2 (for SARS-CoV-2), aminopeptidase N (f

105 ed for fast mapping of peptides into UniProt entries for the human, mouse and other commonly used mod

106 The intestinal tract represents a portal of entry for many infectious agents; however, to date speci

107 As the main portal of entry for shrimp-related pathogens remain unclear, infec

108 utpatient clinics represent the key point of entry for timely access to palliative care.

109 The new entry format provides a greater flexibility, simplifies

110 The current expansion includes new entries from the most recent collections of transcriptio

111 ally large number of proteins comprising the entry/fusion complex (EFC), which enables infection of d

112 a 36-residue peptide drug that inhibits HIV entry/fusion.

113 mitochondrial membrane (TOMM) complex is the entry gate for virtually all mitochondrial proteins and

114 ing of Mcm2-7 on DNA is complete and the DNA entry gate is fully closed.

115 Then, the ubiquitous entry gate to within the cells' cytoplasm is macropinocy

116 ellular trafficking pathways to permit viral entry, gene expression, assembly, and egress is poorly u

117 been identified, and the mechanisms of cell entry have been elucidated.

118 istinct from other factors that modulate CoV entry.IMPORTANCE Virus entry into host cells is one of t

119 nduced weight changes and increased open-arm entries in the elevated plus maze (EPM).

120 which relies on apical constriction, mitotic entry in an artificially contractile ectoderm induced ec

121 chemokine receptors (CCR5 and CXCR4) to gain entry in human cells.

122 HIV by autophagy, trehalose decreased viral entry in human primary macrophages and CD4(+) T cells th

123 used to assess potential pathways for water entry in leaves of beech, a widely distributed tree spec

124 ty function score which was the first placed entry in the official phase of the challenge.

125 the potential role of store-operated Ca(2+) entry in these processes.

126 of LCCBs activate STIM/ORAI-mediated Ca(2+) entry in VSMCs.

127 ich has been associated with SARS-CoV-2 cell entry, in the nasal epithelium of children vs adults.

128 is of cyclin B and securin promotes anaphase entry, inactivating CDK1 and permitting chromosome segre

129 tect the endothelial barrier against calcium entry-induced disruption.

130 Further, calcium entry-induced endothelial barrier disruption is decrease

131 TfR1 or hTfR1 comparably enhances JUNV virus entry/infectivity.

132 Of note, pretreatment with an HBV entry inhibitor attenuated the TLR2-mediated response to

133 In this study, we report that the viral entry inhibitor BMS-626529 restricts trimer conformation

134 of FDA-approved drugs as a potent EBOV viral entry inhibitor, via binding to EBOV glycoprotein (GP).

135 While premature mitotic entry inhibits mesoderm invagination, which relies on ap

136 The model starts at mitotic entry initiated by the activities of Cyclin-dependent ki

137 ty of this projection, which correlates with entries into the cocaine-paired chamber.

138 3 in seed maturation, desiccation tolerance, entry into a quiescent state and longevity.

139 d loop with four major steps: attachment and entry into a target cell, replication of the viral genom

140 l three proteins exhibit restricted rates of entry into and escape from the microdomain as well as en

141 GFP-ts045 demonstrated significantly delayed entry into and exit from the Golgi in fibroblasts derive

142 Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies.

143 tudies have refined our model of herpesvirus entry into cells, clarifying both the conserved features

144 ell types, and enhances virus attachment and entry into cells.

145 sites that are critical for inhibiting viral entry into cells.

146 us surface spike protein mediates SARS-CoV-2 entry into cells.

147 d of gp120 and gp41 subunits, mediates viral entry into cells.

148 ociated virulence factor InlB, which enables entry into certain host cells.

149 e SARS-CoV-2 spike (S) glycoprotein promotes entry into host cells and is the main target of neutrali

150 ors that modulate CoV entry.IMPORTANCE Virus entry into host cells is one of the key determinants of

151 A (OmpA) are essential for optimal bacterial entry into host cells, but their relevance to infection

152 E2 receptor plays an essential role in viral entry into host cells.

153 rent lineage B viruses can recombine to gain entry into human cells, and confirm that human ACE2 is t

154 lectivity provide the first highly selective entry into KDO equatorial glycosides such as are found i

155 Following mycobacterial entry into macrophages the ESX-1 type VII secretion syst

156 thought to be the primary pathway for Ca(2+) entry into mitochondria in eukaryotes.

157 Here we show that entry into mouse torpor, a fasting-induced state with a

158 ion (GSIS) is regulated by calcium (Ca(2+) ) entry into pancreatic beta-cells through voltage-depende

159 d synchronization facilitated robust calcium entry into Primed Neurons.

160 lin-dependent kinase inhibitors, by blocking entry into quiescence.

161 d render RB inactive in late G1/S, promoting entry into S phase.

162 Entry into such a state can occur as a direct response t

163 A2 binding affinity by KSHV.IMPORTANCE Virus entry into target cells is the first step for virus infe

164 During HIV-1 entry into target cells, binding of the virus to host re

165 Upon entry into target cells, the viral core undergoes a proc

166 These cycloadducts provide a convenient entry into the 3-azabicyclo[3.2.0]heptane scaffold throu

167 redistribution may facilitate hepatocyte re-entry into the cell cycle.

168 Leukocyte entry into the central nervous system (CNS) is essential

169 lectively activates PrL->NAcC cells prior to entry into the cocaine-paired chamber, a measure that is

170 ge of the total population was 32.1 years at entry into the cohort and 48.7 years at the time of the

171 ollowing cleavage of the signal peptide upon entry into the endoplasmic reticulum (ER), the peptide p

172 After entry into the endosome, sigma3 is proteolytically degra

173 demonstrated that CD21 is necessary for EBV entry into the Jurkat T-cell line.

174 lated respiration, effects requiring betaOHB entry into the neuron, and protects from glutamate excit

175 which we propose positions the substrate for entry into the pore.

176 Improving drug entry into the testes with drugs that use endogenous tra

177 creened, 2,007 were molecularly eligible for entry into the trial, and 302 entered the trial to recei

178 red IL-2-induced effects, promoting pyruvate entry into the tricarboxylic acid cycle and inhibiting t

179 C, whereas the mutation of hapR led to fast entry into the VBNC state.

180 Fusion with, and subsequent entry into, the host cell is one of the critical steps i

181 id at low pH and facilitating a late step in entry involving uncoating and delivery of the RNA genome

182 tissue and host specificity; however, viral entry is a complex process requiring the concerted actio

183 Virus entry is a multistep process.

184 w that host protease processing during viral entry is a significant barrier for several lineage B vir

185 ell attachment.IMPORTANCE Nonenveloped virus entry is an incompletely understood process.

186 Efficient S phase entry is essential for development, tissue repair, and i

187 S phase entry is mitogen-independent in the daughter G1 phase, b

188 Imported text entries made up the majority of text in new and return p

189 Understanding the overall entry mechanism, including the binding mechanism of spec

190 nd that LY6E also efficiently restricted the entry mediated by the envelope spike proteins of other h

191 The immune modulatory protein herpes virus entry mediator (HVEM) is one of several cellular recepto

192 centa minimally expresses the canonical cell-entry mediators for SARS-CoV-2.

193 The structural profiles for each TFBS entry now include 13 shape features and minor groove ele

194 ein (G) demonstrated that GRP-60367 inhibits entry of a subset of RABV strains.

195 tes are therefore critical for selective CNS entry of autoantibodies, microglial activation, and neur

196 ies, including the regulation of growth, the entry of beneficial microbes, and protection against pat

197 es the IRT1 transporter that also allows the entry of certain non-iron metals, such as Zn, Mn, and Co

198 he predominant control mechanism for S phase entry of daughter cells.

199 receptor 1 (LYVE-1) mediates the docking and entry of dendritic cells to lymphatic vessels through se

200 They also mediate the entry of enveloped viruses by binding PS in the virion m

201 During cell injuries, the entry of extracellular Ca(2+) activates the annexin memb

202 we found that in addition to stimulating the entry of glucose and glutamine carbon into the TCA cycle

203 We also report that entry of gRNA into the host cytoplasm requires the F-pla

204 ILT or ADAP2, in HEK 293 cells inhibited the entry of HCoV-O43.

205 erve that the ascarosides that promote dauer entry of larvae also act on adult animals to attenuate e

206 These results complete the DNA path from entry of parental DNA into CMG to exit of daughter DNA f

207 his important barrier that normally prevents entry of pathogens, immune cells, and cytokines into cer

208 ription through constraints on cell cycle re-entry of quiescent hepatocytes.

209 Third, unlike SARS-CoV, cell entry of SARS-CoV-2 is preactivated by proprotein conver

210 ts, and pangolins, were able to support cell entry of SARS-CoV-2, suggesting that these species might

211 he endoplasmic reticulum (ER) via the Guided-Entry of TA proteins (GET) pathway.

212 The guided entry of tail-anchored proteins (GET) pathway targets an

213 The entry of the virus into cells depends on the receptor-bi

214 y syncytial virus (RSV) fusion protein block entry of the virus into the cell and have shown varying

215 tes TNFR2 expression and promotes cell cycle entry of tubular epithelial cells.

216 proteomic strategy to track the early-stage entry of ZIKV into host cells.

217 ubunit was not absolutely required for virus entry or syncytium formation, alteration of palmitoylate

218 ration of this process nor definition of the entry pathway of P(i) into SR are fully established.

219 uld increase P use efficiency; however, leaf entry pathways for inorganic phosphate ion (Pi) uptake r

220 ar active site Cu(Z), the binuclear electron entry point Cu(A) is also utilized in other enzymes, inc

221 The entry point for the virus is ACE2, which is a component

222 ing birch tree mutant and provides a genetic entry point into the biomechanical control of tree allom

223 A technical accuracy at bone entry point of 0.48 +/- 0.44 mm and 0.68 +/- 0.58 mm was

224 ss exposure, our findings suggest a synaptic entry point of the BDNF/TrkB system for adaptation to st

225 and entire animals have served as invaluable entry points for ensuing dissection of their evolution,

226 follicle-associated epithelia (FAE) to limit entry points for STm invasion.

227 netic risk factors and potential therapeutic entry points.

228 ion protein (F) plays a crucial role for the entry process and spread of infection by mediating fusio

229 s many stages of the influenza A virus (IAV) entry process, including initial binding of IAV to sialy

230 folding of helix 2 is relevant to the ligand entry process.

231 mmalian cells typically start the cell-cycle entry program by activating cyclin-dependent protein kin

232 gest this loop confers fusion activation and entry properties more in line with betacoronaviruses in

233 pulmonary expression of the SARS-CoV-2 viral entry receptor angiotensin-converting enzyme-2 (ACE2).

234 verting enzyme 2(ACE2) was identified as the entry receptor for SARS-CoV-2.

235 KREMEN1 (KRM1) is the entry receptor for the largest receptor-group of hand-fo

236 Knowledge of the entry receptor is key to understand SARS-CoV-2 tropism,

237 giotensin-converting enzyme 2 (hACE2) as the entry receptor.

238 ps can be predesigned for viruses with known entry receptors for faster therapeutic response without

239 The intracellular itinerary for HSV entry remains unclear.

240 However, the host factors critical for its entry, replication, and assembly are poorly understood.

241 ify valid therapeutic tools to control virus entry, replication, and spread as well as to impair its

242 iles of Cuban Americans in Texas differed by entry route.

243 tube insertion position 1), less than 50% of entry site anterior to SL (tube insertion position 2), m

244 tion 2), more than 50% but less than 100% of entry site anterior to SL (tube insertion position 3 [TI

245 Schwalbe's line (SL), defined as all of the entry site behind SL (tube insertion position 1), less t

246 er, the nicked NEIL2 product can serve as an entry site for Exo1 in vitro to generate single-stranded

247 n cellular hub of lipid biosynthesis and the entry site for the secretory pathway.

248 insertion position 3 [TIP3]), and all of the entry site in front of SL (tube insertion position 4 [TI

249 anterior chamber (AC) flare; tube insertion entry site position relative to Schwalbe's line (SL), de

250 sive in the absence of a model for the viral entry site.

251 ne chain of P is bound near the L nucleotide entry site.

252 Viruses use internal ribosome entry sites (IRES) to hijack host ribosomes and promote

253 /ORAI proteins mediate store-operated Ca(2+) entry (SOCE) and drive fibro-proliferative gene programs

254 SYT1 and ESYT2 reduced store-operated Ca(2+) entry (SOCE) and ORAI1-STIM1 clustering in Jurkat T cell

255 nized as a mediator of store-operated Ca(2+) entry (SOCE) in nonexcitable cells.

256 Store-operated calcium entry (SOCE) is important in the maintenance of calcium

257 Store-operated Ca2+ entry (SOCE) is the major route of Ca2+ influx in platel

258 (2+) flux through the store-operated calcium entry (SOCE) pathway and accompanied plasma membrane dep

259 were not affected, but there were impacts on entry, spread, and neutralization by anti-gH antibodies.

260 ing that the cause of resistance lies in the entry step of MNV infection.

261 in neonatal lymph nodes and gut, where, upon entry, they upregulate T-bet and coexpress IL-17, IL-22,

262 ole-body MRI was performed within 2 weeks of entry; those with extraosseous disease were excluded.

263 R dysfunction in platelets increased calcium entry though the transient receptor potential cation cha

264 with 1 of 17 fast-track drugs facing generic entry through July 2019.

265 between these two NP types during their cell entry through receptor-mediated macropinocytosis.

266 ws randomly across the leaf surface prior to entry through stomata.

267 ts HIV through two mechanisms: (i) decreased entry through the downregulation of CCR5 in T cells and

268 assembly is independent of Ca(V)2s or Ca(2+) entry through them.

269 in, suggesting a novel way to regulate brain entry through vascular wall remodeling.

270 motherapies as the former prevent cell-cycle entry, thus interfering with S-phase- or mitosis-targeti

271 To account for different entry times among cohorts, we introduced a horizontal tr

272 formed extensive manual data curation of all entries to improve the annotation quality of our reposit

273 emodelers to allow recruitment of Pol II and entry to a promoter-proximal paused state, and also to p

274 7 compared with white race), and more recent entry to care (since 2005 compared with 1994-2004).

275 ous chondrite meteoroids tend not to survive entry to Earth's atmosphere.

276 ugh the Golgi occurs in an anterograde (from entry to exit) or retrograde fashion are still strongly

277 due to lipid peroxidation, allowing calcium entry to initiate lysosome fusion.

278 of the alpha-chloroenamides provides direct entry to polyfunctionalized acyclic enamides, compounds

279 ytosol, where it disassembles before nuclear entry to promote infection.

280 Direct entry to the cytosol is challenging due to the impermeab

281 (S-protein), a critical element of the viral entry to the host cell, and ACE2, its docking site on th

282 extracellularly and block its attachment and entry to the host cells.

283 This gives entry to the synthesis of multiply substituted BCP triaz

284 As an entry to these circuits, we provide detailed anatomy of

285 trial participants (males, 4 to <7 years at entry) treated with 2.0 or 6.0 mg/kg/day vamorolone for

286 ome (MERS) coronavirus spike, mediates viral entry using pseudovirus entry and biochemical assays.

287 e compound Golgicide A (GCA) inhibited HSV-1 entry via beta-galactosidase reporter assay and impaired

288 ion studies demonstrated that DIDS inhibited entry via direct interaction with the virion that impede

289 During entry, viruses must navigate through the host endomembra

290 Precision of data entry was confirmed by inter-rater reliability (IRR).

291 Our entry was the unexpected observation that deletion of Bi

292 e ACE2 receptor in the early stages of viral entry, we show that loss of RAB7A reduces viral entry by

293 2.9% (450 173 of 1 366 736) of the one-badge entries were judged to be informative.

294 hose found in infectious virions before cell entry were observed upon mutation of a single amino acid

295 ified to function in interference with virus entry, were expressed at significantly higher levels in

296 atory syndrome, including the system of cell entry, which is triggered by binding of the viral spike

297 s peri-infarct zone forms a substrate for re-entry while arrhythmia initiation is often associated wi

298 tion of Ebola virus glycoprotein-driven cell entry (with IC(50) values down to 95 pM), but only parti

299 ther optimization as inhibitors of filovirus entry, with the potential to be developed as therapeutic

300 ns fail to regenerate across the dorsal root entry zone (DREZ) to extend into the spinal cord.