ライフサイエンスコーパス: enucleate

1 pical discoidal erythroid shape but they can enucleate.

2 Like their adult counterparts, EryP enucleate.

3 ar by what mechanism primitive erythroblasts enucleate.

4 er, express mostly fetal hemoglobin, and can enucleate.

5 death caused by failure of erythroblasts to enucleate.

6 noblastoma patients revealed that 70.8% were enucleated.

7 The eye was subsequently enucleated.

8 l culture medium, the uninoculated eyes were enucleated.

9 ired penetrating keratoplasty, and 1 eye was enucleated.

10 4.2%) required EBRT and 13 eyes (30.2%) were enucleated.

11 ndergoing salvage therapy that have not been enucleated.

12 On postnatal day 17, eyeballs were enucleated.

13 of nanoparticle carboplatin in the eye to be enucleated.

14 Eyes were enucleated 1 day, 1 week, and 1 month after injection.

15 Eyes were enucleated 4 hours after antigen challenge, and inflamma

16 Both eyes in each animal were enucleated 6 hours after the final procedure, before eut

17 Two eyes were enucleated 6, 24 and 72 hours post injection.

18 Of the 28 treated eyes, 9 were enucleated, 6 for recurrent retinal disease, resulting i

19 ing the early subjective night using animals enucleated 60 days earlier, there were neither effects o

20 als, although robust reactivation similar to enucleated adults (P120) was not achieved yet.

21 into NU/NU or C57Bl/6 mouse eyes which were enucleated after 7 days.

22 er lymphatic vessels can be detected in eyes enucleated after an open globe injury.

23 vessels were detected in 15 of 21 eyes (71%) enucleated after an open globe injury.

24 Rhesus monkey eyes of different ages were enucleated after death, fixed in 4% paraformaldehyde for

25 ndothelial marker in 21 globes that had been enucleated after open globe injury.

26 All the eyes were enucleated after recurrence.

27 analysis shows that both non-enucleated and enucleated amoebas display the same kind of dynamic migr

28 movement trajectories of enucleated and non-enucleated amoebas on flat two-dimensional (2D) surfaces

29 Given that phloem sieve elements are enucleate and lack translation machinery, RNA function r

30 Three and 24 hours after EIU, eyes were enucleated and aqueous humor (AqH) was collected.

31 The eyes were enucleated and embedded in paraffin, and sections were p

32 Our analysis shows that both non-enucleated and enucleated amoebas display the same kind

33 Both eyes were enucleated and examined by immunohistochemical analysis

34 by using magnetic resonance imaging (MRI) of enucleated and fellow orbits.

35 Eyes were enucleated and fixed, and the posterior eye cups were fl

36 A week later, the eyes were enucleated and high resolution maps of the retina vascul

37 d three eyes at 48 hours, respectively, were enucleated and immediately frozen and stored at -80 degr

38 Eyes were enucleated and immediately frozen.

39 Since erythrocytes are enucleated and lack DNA, genetic approaches to understan

40 e have analyzed the movement trajectories of enucleated and non-enucleated amoebas on flat two-dimens

41 Microtubule arrays in enucleated and nucleated cells are morphologically indis

42 rfused with glutaraldehyde and the eyes were enucleated and prepared for transmission electron micros

43 The eyes were enucleated and processed for immunohistochemistry and in

44 Their eyes were enucleated and processed for immunohistochemistry to det

45 ed clinically prior to euthanatization, then enucleated and processed for light microscopy and immuno

46 rs after AdL.11D injection and the eyes were enucleated and stored until assayed.

47 These cybrids were enucleated and the cytoplasts were electrofused to rhoda

48 ect to these parameters between the prenatal enucleates and normal monkeys of comparable age.

49 as been unknown whether human primitive RBCs enucleate, and what hematopoietic site might support thi

50 ter 24 hours the rats were killed, eyes were enucleated, and aqueous humor (AqH) was collected.

51 The eyes were enucleated, and both optic nerves were dissected and pro

52 e killed at regular time intervals, the eyes enucleated, and drug content quantified in the vitreous

53 72 hours post injection (pi), the eyes were enucleated, and frozen sections were stained with antibo

54 FITC high-molecular-weight dextran, the eyes enucleated, and neovascularization analyzed by confocal

55 s after injection, animals were killed, eyes enucleated, and retinal sections studied by histochemist

56 Eyes of animals in all groups were enucleated, and retinas were removed and stained with ad

57 The eyes were enucleated, and the neural retinas were separated from t

58 axotomy, the rats were killed, the eyes were enucleated, and the retinas were stained for OX42.

59 periment, animals were euthanized, eyes were enucleated, and the TM was dissected and stored in an aq

60 Rabbits were then killed, eyeballs enucleated, and their ocular volumes determined.

61 Eyes were enucleated, and tumor sections were analyzed.

62 mirror-symmetric map observed in neonatally enucleated animals, are present by P6-7, just as collate

63 s and induction occurred in both sighted and enucleated animals.

64 halan and topotecan in eyes not subsequently enucleated appears to be safe and effective for resistan

65 3 or 24 hours after LPS injection, eyes were enucleated, aqueous humor (AqH) was collected, and the n

66 ogic features in group D retinoblastoma eyes enucleated as primary or secondary treatment.

67 of Bruch's membrane and were killed and eyes enucleated at 1, 2, 3, and 4 weeks after laser injury.

68 Eyes were enucleated at 20 weeks of age, snap frozen, and analyzed

69 Eyes were enucleated at 21 weeks of age and examined for residual

70 Eyes were enucleated at 5 to 25 hours after infection and CAP37 de

71 Two eyes were enucleated at 5.5 and 20 months after implantation and a

72 ning at 24 months, eyes from each group were enucleated at approximately 6-month intervals.

73 ed the mirror-symmetric pattern seen in rats enucleated at birth (P0).

74 ts, striate-extrastriate projections in rats enucleated at birth consisted of multiple, well-defined

75 c cortical loci, whereas in rats bilaterally enucleated at birth, callosal fibers connect topographic

76 ortical loci, whereas in animals bilaterally enucleated at birth, callosal fibers connect topographic

77 to measure the KLF6 transcript level in eyes enucleated at embryonic stages, and the corneas and lens

78 at the patterns of callosal linkages in rats enucleated at P12, P8, and P6 were nonmirror-symmetric,

79 n contrast, the patterns of linkages in rats enucleated at P4 closely resembled the mirror-symmetric

80 comparing cortical activity patterns of mice enucleated at postnatal day (P) 45, 90, or 120.

81 triate projections were not observed in rats enucleated at postnatal day (P)6, although the size of a

82 ection of either viral vector, and eyes were enucleated at specified times after injection for histop

83 ond protocol, activated in vivo oocytes were enucleated at the telophase II stage, electrofused with

84 Eyes were enucleated at various time points for quantitative funga

85 Photodisruption of the TM in enucleated baboon eyes and human donor eyes was performe

86 in normal ferrets and in ferrets bilaterally enucleated (BE) at postnatal day 7 (P7) or P20.

87 erythroblasts mature in the bloodstream and enucleate between embryonic day (E)14.5 and E16.5 of mou

88 Primitive erythroblasts progressively enucleate between embryonic days 12.5 and 16.5, generati

89 Enucleated bovine and porcine (n = 59 each) eyes were us

90 Fresh enucleated bovine eyes were obtained from a local abatto

91 Enucleated bovine eyes were perfused at 1 of 4 different

92 tudies indicate that primitive erythroblasts enucleate by nuclear extrusion to generate erythrocytes

93 While definitive erythroblasts enucleate by nuclear extrusion, generating reticulocytes

94 tream indicates that primitive erythroblasts enucleate by nuclear extrusion.

95 -tubulin to fluorescently label MTs and were enucleated by using a centrifugation procedure.

96 ic modulus was measured for nucleated cells, enucleated cells and nuclei (day 14) of 1.04 +/- 0.47 kP

97 rimental system to examine Ad trafficking in enucleated cells compared to Ad trafficking in intact, m

98 rated by fusing mtDNA-less rho(o) cells with enucleated cells from LHON patients carrying both m.1177

99 Ad localization to the MTOC in the enucleated cells was stable, as demonstrated by continui

100 Treatment of enucleated cells with arsenic followed by rescue fusion

101 Upon infection of enucleated cells with Cy3-labeled Ad, the majority of Ad

102 ) between the deformability of nucleated and enucleated cells, while they remain within the same size

103 cuole formation, increased the percentage of enucleated cells.

104 s compared to Ad trafficking in intact, mock-enucleated cells.

105 decreased, including reduced percentages of enucleated cells.

106 providing insight into previous studies with enucleated cells.

107 t are depleted in terminally differentiating/enucleating cells with decreasing transcriptional capaci

108 By artificially enucleating cells, we show that arrays can form de novo

109 r, area 17, but not area 18a, was smaller in enucleates compared to controls, resulting in an increas

110 Upon the completion of MRI, mouse eyes were enucleated, cryosectioned, and stained for assessing ret

111 g cell line devoid of mitochondrial DNA with enucleated cytoplasm from either a Large White pig or a

112 The enucleated definitive erythrocytes of mammals are unique

113 Eyes were enucleated, dissected, and assayed for changes in the ra

114 Eyes were enucleated, dissected, and snap-frozen, or they were fix

115 genomes from metaphase II (MII) oocytes into enucleated donor MII cytoplasm (PBNT).

116 Sixty-nine eyes were enucleated during the first 5 years after brachytherapy,

117 transplantation of a somatic nucleus into an enucleated egg and most recently by introducing defined

118 nsplantation of a somatic cell nucleus to an enucleated egg results in a major reprogramming of gene

119 he transplantation of somatic cell nuclei to enucleated eggs has shown that genes can be reprogrammed

120 h inactive 5Sooc genes, were transplanted to enucleated eggs, the resulting nuclear-transplant embryo

121 otein (GFP), were transplanted into manually enucleated eggs.

122 ytes at the arrested metaphase II stage were enucleated, electrofused with donor somatic cells, and s

123 Compared with enucleated end-stage glaucoma eyes, this represents a 10

124 reticulocyte and nucleus, in a population of enucleating erythroblasts.

125 Although the mature enucleated erythrocyte is no longer active in nuclear pr

126 tial, despite prolonged culture, to generate enucleated erythrocytes after 3-4 maturational cell divi

127 of the animals, with a dramatic reduction in enucleated erythrocytes and the presence of immature meg

128 This network dictates the genesis of enucleated erythrocytes by orchestrating the survival, p

129 w (BM) early stage erythroblasts and reduced enucleated erythrocytes compared to CMML patients with W

130 finitive erythroid lineage generates smaller enucleated erythrocytes that become the predominant cell

131 genitor cells with unproductive synthesis of enucleated erythrocytes, leading to anemia and hypoxia.

132 ently die with failure to produce definitive enucleated erythrocytes.

133 s increases from early progenitors to mature enucleated erythrocytes.

134 crophages increase the production of mature, enucleated erythroid cells from umbilical cord blood der

135 Definitive erythroblasts mature and enucleate extravascularly and form a unique membrane ske

136 on biopsy [FNAB] compared with tumor from an enucleated eye), tumor basal diameter and height, and ci

137 conjunctiva in the socket of his previously enucleated eye, as well as lower eyelid ectropion, resul

138 erritories normally innervated by the other (enucleated) eye.

139 another animal onto the denuded stroma of an enucleated eyeball.

140 er mouse was placed on the bare stroma of an enucleated eyeball.

141 ing the denuded cornea before incubating the enucleated eyeball.

142 A retrospective case series of 12 enucleated eyes (11 patients) with retinoblastoma refrac

143 of-concept, laboratory-based study, 16 human enucleated eyes (8 with neovascular glaucoma and 8 as co

144 in live rabbit eyes (in vivo) and in freshly enucleated eyes (ex vivo).

145 g (d7-d13) and histopathologic evaluation of enucleated eyes after experimental termination.

146 Histologic tumor burden was quantified in enucleated eyes by image processing software, and microv

147 dividuals and biallelic BEST1 mutations, and enucleated eyes from 2 individuals with nonaffected reti

148 Subsequently analysis of the retinas of nine enucleated eyes from males with Coats' disease demonstra

149 Histology of the enucleated eyes injected with CD34(+) cells showed no in

150 lar meshwork from three sources was studied: enucleated eyes obtained at autopsy, trabeculectomy spec

151 the anterior segment, lens, and retina from enucleated eyes of C57BL/6, thrombospondin-1 knockout (T

152 Macroscopic photographs of the enucleated eyes of patients with retinoblastoma were ana

153 The enucleated eyes of the experimental mice were subjected

154 Enucleated eyes received at the pathology department of

155 lted in the majority of treated eyes and the enucleated eyes showed evidence of hyphae.

156 p corneal puncture injury model for use with enucleated eyes that utilizes a high-speed solenoid devi

157 The frequency of secondary enucleated eyes was 6.7% (n = 5).

158 The ocular shape of enucleated eyes was photographed during a 24-hour period

159 Animals were euthanized on day 14, and enucleated eyes were analyzed by light microscopy and im

160 Frozen sections of the enucleated eyes were analyzed for iNOS by the dual immun

161 of NF-1 associated with glaucoma, from which enucleated eyes were available, and 2 eye bank eyes used

162 Their enucleated eyes were examined for microglial expression

163 Enucleated eyes were processed for hematoxylin and eosin

164 Five therapeutically enucleated eyes were sampled in triplicate for ex vivo d

165 The enucleated eyes were stained for OX42 and examined by co

166 Of 519 primarily enucleated eyes, 87 (17%) were classified as group D and

167 the grafts was determined in cryosections of enucleated eyes, and GFP expression in the grafts was vi

168 oblastoma was identified in 23% (117/519) of enucleated eyes, including 17% (15/87) group D and 24% (

169 In the 26 enucleated eyes, other features included retrolental neo

170 treous Gd-DTPA concentration occurred in the enucleated eyes, suggesting that there are significant b

171 ppressor pathways in 33 uveal melanomas from enucleated eyes.

172 was the most prevalent seeding type of the 9 enucleated eyes.

173 y was then correlated with histopathology in enucleated eyes.

174 sed on centralized histologic examination of enucleated eyes.

175 which were also passively exposed to freshly enucleated eyes.

176 imary RPE sheets were harvested from freshly enucleated female porcine eyes and embedded in a thin sl

177 The surface of the skin is composed of enucleated, flattened surface squames.

178 d 1 to 7 days after injection, and eyes were enucleated for fluorescent or transmission electron micr

179 s at its peak, and the eyes were immediately enucleated for histologic and biochemical studies.

180 Both eyes were enucleated for histologic evaluation.

181 At P17, mice were killed and eyes enucleated for quantitation of retinal neovascularizatio

182 to categorize corneal inflammation and were enucleated for quantitative fungal cultures, analysis by

183 stopathologic risk factors in eyes primarily enucleated for retinoblastoma.

184 ion and no eye was treated with radiation or enucleated for seeding.

185 the embryo for several days before the first enucleated forms can be identified in the blood.

186 ogic correlation of consecutive group D eyes enucleated from 2002 to 2014.

187 odds ratio [OR], 0.49; 95% CI, 0.22-1.10) or enucleated glaucomatous eyes (OR, 0.66; 95% CI, 0.15-2.8

188 M eyes, 9 (1.7%) eye bank eyes, and 2 (1.3%) enucleated glaucomatous eyes.

189 ing 1985 UM eyes, 517 eye bank eyes, and 155 enucleated glaucomatous eyes.

190 Outflow facility was measured in enucleated glaucomatous human eyes.

191 Light microscopic examination of an enucleated globe as well as fibrous retroprosthetic memb

192 d one group of four age-matched, noninflamed enucleated globes (control samples) were used.

193 Two groups of four enucleated globes (total eight globes) from patients wit

194 Five enucleated globes and 1 cytology sample from a patient w

195 All 5 enucleated globes displayed retinal detachment, fibrous

196 Clinical records and microscopic slides of 4 enucleated globes were reviewed.

197 Frozen sections of enucleated globes with intact EOMs and associated connec

198 A retrospective study of enucleated globes with the diagnosis of retinoblastoma r

199 Ten enucleated globes with the histopathologically and immun

200 rane formation and retinal detachment in all enucleated globes.

201 ion pTNM), and 5 eyes (21%) of the secondary enucleated group (pT2bNxM0, n = 2, pT3aNxM0, n = 2 and p

202 e entire cohort, 5 eyes (13%) of the primary enucleated group (pT3aNxM0, n = 2 and pT3bNxM0, n = 3, 8

203 A total of 64 enucleated group D eyes (62 patients), of which 40 (40 p

204 Secondary enucleated group D eyes with high-risk histopathologic f

205 Sixteen enucleated human eyes were perfused with PBS plus glucos

206 40 expression by infiltrating lymphocytes in enucleated human eyes with end-stage inflammation.

207 fusing an adult somatic cell to a previously enucleated human oocyte, in agreement with recent report

208 et of CSLT-detected ONH surface change) were enucleated immediately after death and immersion fixed a

209 24 hours after LPS injection, the eyes were enucleated immediately, and aqueous humor (AqH) was coll

210 BALB/c) were euthanatized, and the eyes were enucleated, immersed in 2% glutaraldehyde fixative, and

211 udies have shown that primitive RBCs in mice enucleate in the fetal liver.

212 r than the bloodstream, suggesting that they enucleate in the liver, a possibility supported by their

213 Late-stage primitive erythroblasts fail to enucleate in vitro unless cocultured with macrophage cel

214 ap reflection, a solid, rubbery specimen was enucleated in one piece leaving a wide moat-like intrabo

215 that the failure of Rb-null erythroblasts to enucleate is due to defects in associated macrophages.

216 re monitored by slit lamp biomicroscopy, and enucleated lenses were examined under a stereomicroscope

217 fective transport, sieve elements develop as enucleated living cells.

218 ne was selected, and the cells were fused to enucleated mature oocytes.

219 ng factors was documented in both intact and enucleated metaphase and interphase zygotes and two-cell

220 tion, a phenotype that was mimicked in adult enucleated mice when treated with indiplon, a GABAA rece

221 oid donor nuclei have been transplanted into enucleated MII oocytes that are activated on, or after t

222 omosomal complex transfer from one egg to an enucleated, mitochondrial-replete egg.

223 lateral geniculate nucleus of the prenatally enucleated monkey is due to the maintenance of a conting

224 lls that showed loss of IGF2 imprinting into enucleated mouse and human fibroblasts that had maintain

225 to measure conventional outflow facility in enucleated mouse eyes ex vivo.

226 Freshly enucleated mouse eyes were imaged using two nonlinear op

227 Freshly enucleated mouse eyes were incubated with human MMP-1, -

228 were detectable up to 24 hours postmortem in enucleated mouse eyes.

229 nd cumulus cells) taken from adult mice into enucleated mouse oocytes.

230 y or to increase membrane CD35 expression in enucleated neutrophil cytoplasts.

231 d with complete Freund's adjuvant; eyes were enucleated on day 7 after immunization.

232 Both eyes of each mouse were enucleated on postinoculation day 15 and processed for h

233 Eleven eyes were enucleated: one at diagnosis, nine with progressive dise

234 is fused by electoporation with a recipient enucleated oocyte.

235 tomere nucleus from a four-cell embryo to an enucleated oocyte; however, no live offspring were obtai

236 Enucleated oocytes have the distinctive ability to repro

237 ei of cultured LacZ-positive fibroblasts and enucleated oocytes of a different mouse strain.

238 s post coitum; however, a high percentage of enucleated oocytes receiving cumulus nuclei developed in

239 We found that some enucleated oocytes receiving Sertoli or neuronal nuclei

240 itum) and their nuclei were transferred into enucleated oocytes, 5.5% of the reconstructed oocytes de

241 ere used as nuclear donors for transfer into enucleated oocytes, and the resulting blastocysts were c

242 8.5, 9.5, and 10.5 dpc were transferred into enucleated oocytes, seven cloned embryos developed into

243 by injecting U2 RNA into isolated nuclei or enucleated oocytes, we observe that U2 internal modifica

244 sheep was derived exclusively from recipient enucleated oocytes, with no detectable contribution from

245 yonic development, we transplanted them into enucleated oocytes.

246 ys appear to retain their functional role in enucleated orbits.

247 by transfer of a donor cell nucleus into an enucleated ovum, and now we add the successful cloning o

248 stal to the inner wall Schlemm's canal in an enucleated perfused human eye.

249 uclear donors for embryos reconstructed with enucleated pig oocytes.

250 considered a nuclear receptor, we show that enucleate platelets highly express PPARgamma protein as

251 hat Sirt1, Sirt2, and Sirt3 are expressed in enucleate platelets.

252 Enucleated porcine (n = 140) and cadaver human eyes (n =

253 us humor outflow facility was measured using enucleated porcine eyes and a constant-pressure perfusio

254 corneal tissue through a gonioscopic lens in enucleated porcine eyes and of the trabecular meshwork (

255 us humor outflow facility were determined in enucleated porcine eyes by using a constant-pressure Gra

256 Perfusion of enucleated porcine eyes for 5 hours with 100 and 200 mic

257 umor outflow facility increased (40%-80%) in enucleated porcine eyes perfused with Y-27632 (10-100 mi

258 ion of LPA (50 microM) and S1P (5 microM) in enucleated porcine eyes produced a significant decrease

259 Enucleated porcine eyes were perfused in vitro under a c

260 Freshly enucleated porcine eyes were perfused using the constant

261 ons and penetrating keratoplasties (PKPs) in enucleated porcine eyes.

262 flow facility were evaluated by perfusion of enucleated porcine eyes.

263 queous humor (AH) outflow were determined in enucleated porcine eyes.

264 These enucleated primitive erythrocytes circulate as late as 5

265 uniplanar, 3-mm, clear corneal incisions in enucleated rabbit eyes (n = 18).

266 ) was applied to deepithelialized corneas of enucleated rabbit eyes for 2 minutes.

267 Moreover, our results from enucleated rats suggest that the cues that determine the

268 ion of the marker gene on the surface of the enucleated RBC progeny.

269 development, at which time the frequency of enucleated RBCs was higher in the villous stroma than in

270 ntiation of early erythroid progenitors into enucleated RBCs.

271 Chromosomes are then reintroduced into an enucleated recipient egg (cytoplast), derived from anoth

272 poiesis, characterized by anemia and lack of enucleated red blood cells in blood circulation.

273 nificantly enhances the production of mature enucleated red blood cells.

274 ive erythropoiesis-the generation of mature, enucleated red cells.

275 sition from the proerythroblast stage to the enucleated reticulocyte.

276 It results in the release of 2 million new enucleate reticulocytes into your circulation and mine e

277 lls at the end of maturation, which includes enucleated reticulocytes in circulation.

278 ed for the human cells that generates normal enucleated reticulocytes.

279 ch proerythroblasts differentiate to produce enucleated reticulocytes.

280 A control porcine eye was enucleated, retina and RPE isolated, and specimens froze

281 the AH cfDNA and tumor-derived DNA from the enucleated samples was identified.

282 The experimental design was to fertilize enucleate sea urchin eggs with sperm of another species

283 lightly but not significantly greater on the enucleated side.

284 enriched cell fractions and the contents of enucleate sieve elements, in the form of phloem sap, wer

285 A in regulating protein synthesis within the enucleate sieve tube system of the angiosperms.

286 investigated to test the hypothesis that the enucleate sieve tube system utilizes a simplified signal

287 nificance with respect to functioning of the enucleate sieve tube system, as eIF5A was recently detec

288 ribution in higher plants takes place in the enucleate sieve-tube system of the phloem.

289 The enucleated specimen underwent histologic, immunohistoche

290 on, and viable tumor was present in 21 of 22 enucleated specimens (95%).

291 residual viable tumor was present in 95% of enucleated specimens.

292 ultimately sloughed from the skin surface as enucleated squames.

293 Notably, enucleating Tmod3(-/-) erythroblasts are still in the pr

294 Children newly diagnosed with enucleated unilateral retinoblastoma were enrolled prosp

295 tions of S1 in animals that were bilaterally enucleated very early in development, prior to the forma

296 mined in adult animals that were bilaterally enucleated very early in life, before the retino-genicul

297 d precursors proliferate, differentiate, and enucleate, were first described 50 years ago by analysis

298 Axial length was measured on enucleated whole eyes, and ocular structural changes wer

299 EryP home to, complete their maturation, and enucleate within the FL, a tissue that is just developin

300 Eyes were enucleated within 13.5 hours after death.