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2 C5' bond of tau ~ 5-6 s, likely shortened by enzymatic activation as is the case with the Co-C5' bond
3 e indispensable role of FANCB protein in the enzymatic activation of FANCD2 monoubiquitination, an es
5 hylated CpG dinucleotides of DNA and through enzymatic activities for DNA methylation and/or chromati
6 vents at endogenous genomic loci to cellular enzymatic activities in human and mouse cell lines and o
7 sitive quantitative methods to measure their enzymatic activities in mice intranasally challenged wit
8 hosphatase with dual SAC1 and 5'-phosphatase enzymatic activities in regulating phospholipid signalin
10 rgence of these microbe communities or their enzymatic activities might be used to reduce the risk of
11 a SEDS-bPBP complex can coordinate its dual enzymatic activities of peptidoglycan polymerization and
12 ree noncatalytic subunits optimizes the dual enzymatic activities of the catalytic p261 subunit and m
14 tractive concept, since tumor cells may lack enzymatic activities present in normal constitutional ce
15 vels of DNA methylation result from opposing enzymatic activities, the rates of which remain largely
17 cannot interact with SSB but that maintains enzymatic activity (rnhAK60E) eliminates RNase HI foci.
20 observed that this ELANE mutation diminishes enzymatic activity and granulocytic differentiation with
22 isrupt its oligomerization and cause loss of enzymatic activity and translocation from the nucleolus
26 ically associate with others and cooperative enzymatic activity can coevolve, leading to the evolutio
27 tion of the AHR pathway and increased CYP1A1 enzymatic activity compared with healthy donors, suggest
28 utrophil influx into the lungs, and that Pla enzymatic activity contributes to bacterial resistance t
33 que that enables non-invasive measurement of enzymatic activity in real time in living organisms.
34 expressing Cyp1a1 displayed increased CYP1A1 enzymatic activity in the skin, which resulted in exacer
35 with SBI-0206965, potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the vi
38 at phosphorylation-dependent control of TAA1 enzymatic activity may contribute to regulation of auxin
40 tose and 0.17 or 0.19 mol/kg lactose with an enzymatic activity of 2.0 or 2.8 mukat/kg for acid (pH 4
41 es within the disordered CTT to assembly and enzymatic activity of Bacillus subtilis FtsZ (Bs-FtsZ).
47 e (corn, Zea mays) specifically inhibits the enzymatic activity of the secreted chorismate mutase Cmu
48 actose and fructose concentration as well as enzymatic activity of two commercially available beta-ga
50 In the absence of perforin, we show that GrB enzymatic activity still induces substoichiometric activ
52 uide the design of diagnostics that leverage enzymatic activity to measure or produce biomarkers of d
53 determined using six different assays while enzymatic activity was determined by alpha-amylase and t
55 igested in simulated gastric fluid and their enzymatic activity was inhibited upon heat treatment.
57 s been fueled by recent correlations of this enzymatic activity with cardiovascular, neurological, an
58 hway activation reduces ROS generated by QR2 enzymatic activity, a process that alters the intrinsic
59 rrespondingly altered copper binding and the enzymatic activity, as well as intracellular Cu(1+) abun
61 broad and potent capacity to inhibit IBV NA enzymatic activity, neutralize the virus in vitro, and p
62 s cooperative mechanism and leads to reduced enzymatic activity, thus explaining the genomic hypometh
74 es of ABS were applied for measuring general enzymatic activity; however, a recent focus has been pla
76 the NAD(+) hydrolysis assay, and 6.8 in the enzymatic ADP-ribosyltransferase inhibitor dose-response
77 nitric oxide donor S-nitrosoglutathione and enzymatic ADP-ribosyltransferase PtxS1-subunit of pertus
78 alNAc-linked hexasaccharide, suitable for an enzymatic alpha(2,3)-sialylation of the terminal Gal res
79 c suppression of dynamic microtubules by non-enzymatic alphaTAT activity regulates the remodeling of
81 nics, including ion-selective potentiometry, enzymatic amperometry, potential sweep voltammetry, fiel
85 e studies provide a framework for connecting enzymatic and biological functions of specific HDAC comp
88 y (TAC), namely, the overall pattern of both enzymatic and nonenzymatic antioxidant compounds within
89 al metal-oxo moiety are key oxidants in many enzymatic and synthetic C-H bond oxidation reactions.
90 d altered the nonenzymatic (glutathione) and enzymatic antioxidant markers (Glutathione peroxidase, a
91 es of lipid peroxidation and circulating non-enzymatic antioxidants in longitudinally sampled individ
93 hibits SHP2 with an IC(50) = 0.031 muM in an enzymatic assay and with an IC(50) = 2.6 muM in human pa
95 are highly potent inhibitors of DHODH in an enzymatic assay, while also inhibiting cancer cell growt
97 the use of an integrative strategy including enzymatic assays, mutant analysis, metabolic engineering
98 h a combination of yeast complementation and enzymatic assays, show impaired enzymatic activity and s
99 ines are increasingly attractive and include enzymatic asymmetric reductive amination, which offers a
102 es a favourable chemical environment for non-enzymatic beta-catenin acetylation downstream of WNT sig
103 Glucose oxidation and oxygen reduction in an enzymatic BFC supplied electrical power to the ABS.
106 most significant part of the overall fee of enzymatic biomass conversion, the highly efficient recov
108 phenolic compounds from whole-wheat breads: enzymatic bioprocessing and addition of green coffee inf
109 g barrels) on several parameters: color, non-enzymatic browning, antioxidant capacity and phenolic pr
114 cal theory of self-assembly to enumerate the enzymatic causes of oligomer variability and show how to
118 peptidase-4 (DPP4) modulates inflammation by enzymatic cleavage of immunoregulatory peptides and thro
120 do so, we introduced a previously developed enzymatic-cleavage site between helices E and F and pull
121 h in arginine residues reduced the number of enzymatic cleavages to the protein and retained large mo
124 lism as a whole, rather than just individual enzymatic components, is to use a systems biology framew
125 onstrate that the RarA protein makes a major enzymatic contribution to RecA-independent recombination
129 peptidomimetics with improved resistance to enzymatic degradation and/or enhanced affinity toward th
130 these materials to protect proteins against enzymatic degradation is also demonstrated here for the
139 rophilic aromatic substitution, catalyzed by enzymatic deprotonation of substrate, in single-componen
140 or to oncogenic microRNA-21 (pre-miR-21) for enzymatic destruction with selectivity that can exceed t
141 facilitates robust protein extraction, rapid enzymatic digestion (30 min compared to overnight), and
143 ple-transfer steps and facilitate the direct enzymatic digestion of extracted RNA within the sample c
144 reduced to mainly monomers (<100 kDa) after enzymatic digestion of nucleic acids, whereas higher-ord
145 ical sample, conventional RNA extraction and enzymatic digestion protocols that are employed prior to
146 mechanical disruption during digestion, warm enzymatic digestion using enzyme collagenase:NP activity
152 es can simultaneously result in self-powered enzymatic electrosynthesis with more valuable usage of e
153 From the broad substrate scope and the high enzymatic enantioselectivity of LeuDH, the H(2)/alpha-ke
156 ragments (15-20 kb) by magnetic beads, after enzymatic extension of oligonucleotides hybridized to se
158 m Moringa Oleifera defatted leaves (MODL) by enzymatic extraction using Viscozyme L and evaluate its
160 ment of chitin-containing shell waste and an enzymatic/fermentative bioprocess using metabolically en
164 e that is crucial for molecular recognition, enzymatic function, information storage and structure an
165 ting domains, which are required for HDAC3's enzymatic function, permit normal stratification, indica
166 -coordinating aspartate is essential for the enzymatic functions of XoxF MDHs and ExaF EDHs, supporti
170 and dolichylpyrophosphate-linked sugars and enzymatic glycan extension to generate donor and accepto
171 dole moiety was synthesized employing either enzymatic halogenation by halogenases or incorporation o
176 infant milks, including breast milk, during enzymatic hydrolysis of lactose by supplemental beta-gal
180 The extracted arabinoxylan was subjected to enzymatic hydrolysis using individual xylanase, arabinof
181 oreover, by adding a previous step including enzymatic hydrolysis with a xylanase, a functional evalu
184 validated in patient-derived explants where enzymatic inactivation of IKBKE reduced cell proliferati
185 x1-knockout NPCs, H3K27me3 reduction by PRC2 enzymatic inhibitor or genetic depletion partially rescu
186 el for a two-protein system that includes an enzymatic interaction term alongside a simple model of a
188 etratricopeptide repeat (TPR) domains and an enzymatic Jumonji C (JmjC) domain that catalyzes the rem
194 g 1D and 2D NMR, we elucidated the multistep enzymatic mechanism of the oxidoreductase (RgNanOx) that
195 o address this challenge, here we present an enzymatic method to clean up and reconfigure DNA-origami
196 begin by discussing the various chemical and enzymatic methods now available for the manufacture of c
197 rsuit of homogeneity, comprising chemical or enzymatic methods or a combination thereof to afford pre
198 ble emulsion droplets serving as single-cell enzymatic micro-reactors and a commercially available fl
199 erum albumin (BSA) digested by trypsin as an enzymatic model and from solutions of intact BSA and try
202 esent in the nascent glycoproteins (prior to enzymatic modifications in the Golgi), as well as those
204 d the epigenetic landscape by competing with enzymatic modifications, as well as changing the overall
205 r partly sequential and partly nonsequential enzymatic modifications, led us to a verifiable concept
206 nce indicates that the chromatin-binding and enzymatic modules of UHRF1 do not act in isolation but i
207 ins an octamer-like fold, flexibly links the enzymatic modules, and facilitates TBP loading onto TATA
208 s (e.g., substrate channel diffusion) in the enzymatic multistep reactions of individual PCE-RdhAs ra
209 cally stable inhibitors with high potency on enzymatic, NanoBRET, and whole blood assays, improved me
210 Myc poses special problem because of its non-enzymatic nature and certain amount of c-Myc activity is
214 release of arachidonic acid, followed by its enzymatic oxidation resulting in a vast array of eicosan
219 s generally act as chain terminators, and no enzymatic pathway for their polymerization has yet been
221 the most promising metabolites, and identify enzymatic pathways that enable their biosynthetic produc
224 LICK was suggested, consisting of a two-step enzymatic procedure to transform Fc-glycans present on I
225 s system allows for thorough analysis of the enzymatic process through monitoring of its substrate an
232 s of specialized metabolic evolution include enzymatic promiscuity and recruitment of primary metabol
234 M and examined drug susceptibility in vitro, enzymatic properties, replication efficiency, and transm
238 sence of two different protein functions, an enzymatic reaction (alkaline phosphatase, ALP) and a lig
239 he cell-wall cross-links are formed by a non-enzymatic reaction between a sulfonyl fluoride and an am
242 t also, in some cases, in facilitating their enzymatic reaction rates at favorable reaction condition
243 long-chain fatty acids, products of Them1's enzymatic reaction, as well as lysophosphatidylcholine (
245 e use of aqueous microdroplets to accelerate enzymatic reactions and, in particular, to improve prote
246 lidate the method for analyzing steady-state enzymatic reactions associated with P(i) liberation in r
247 zation (DESI) MS for the label-free study of enzymatic reactions directly from the bioassay matrix wi
248 A biosynthesis pathway have been identified, enzymatic reactions leading to the production of these c
249 omologous recombination requires coordinated enzymatic reactions to prepare it for interaction with i
251 f Penicillium simplicissimum, and subsequent enzymatic reactions with these compounds generated two a
253 idin/biotin complex, antibody amplification, enzymatic reactions, triplex structure formation and cat
259 patial decoupling of bulk U(VI) solution and enzymatic reduction should be taken into account for int
264 alterations in gene expression levels of key enzymatic regulators of biochemical reactions linked to
268 validation of the specific high-sensitivity enzymatic reporter unlocking (SHERLOCK) assay using the
269 ters reflect a wealth of previously untapped enzymatic resources hidden in the bee bacteriophage comm
271 gest that the F. alocis SOR protein is a key enzymatic scavenger of superoxide radicals and protects
274 etic tool, we determine the localisation and enzymatic specificity of m(5) C sites in the RNome in vi
275 r some advantage over older BLIs in terms of enzymatic spectrum but are limited to the intravenous ro
276 th indium-111 and lutetium-177 showed a high enzymatic stability in different incubation media as wel
277 sm, including the respiratory chain and each enzymatic step of the tricarboxylic acid (TCA) cycle.
280 ond core isomerization is likely a practical enzymatic strategy to unmask the strong oxidizing power
281 ncy of the plant toxin, ricin, is due to its enzymatic subunit, RTA, which inactivates mammalian ribo
282 ding partners or nucleic acid targets, while enzymatic suppressors covalently modify Cas ribonucleopr
284 ts were required to complete chemical and/or enzymatic syntheses of polysaccharides as long 92-mers.
285 scusses the opportunities and limitations of enzymatic syntheses using distinct examples and provides
287 f peptides in organic solvent as well as the enzymatic synthesis of glycan epitopes in the aqueous ph
288 recent developments and future prospects of enzymatic synthesis of MOS from various mannans, their s
292 demonstrate the effective reconstitution of enzymatic tetracyclization of synthetic teicoplanin-deri
293 nt endothelial stem cells (VESCs) by mechano-enzymatic tissue digestion followed by fluorescence-acti
294 llel nicking on orthogonal DNA fragments and enzymatic toehold creation that enables single-bit rando
295 be functionally similar with respect to the enzymatic transformation of environmentally relevant con
296 s rich chemistry for functionalizing carbon, enzymatic transformations of the heavier homologue silic
297 ical and textural analysis revealed that the enzymatic treatment of zein produced a weaker, more brit
300 nt SAM-alternative for HydG, both supporting enzymatic turnover of substrate tyrosine and forming the