ライフサイエンスコーパス: enzymatic activity

1 ubule depolymerizing effects of TTL from its enzymatic activity.

2 homotetramer and the two forms have similar enzymatic activity.

3 is domain might have other functions besides enzymatic activity.

4 lso present in expression medium and display enzymatic activity.

5 omer and these interactions are required for enzymatic activity.

6 ta, NatB complex formation was essential for enzymatic activity.

7 e to achieve tight spatiotemporal control of enzymatic activity.

8 ry cytokine and chemokine, but also exhibits enzymatic activity.

9 pe of HIV-infected cells but lacks intrinsic enzymatic activity.

10 ects of regulation in parallel to control of enzymatic activity.

11 ons of CD73 may be a means to antagonize its enzymatic activity.

12 NA-PK phosphorylates cGAS and suppresses its enzymatic activity.

13 ng of the complex dynamics that regulate GDH enzymatic activity.

14 ances HDA15HD dimerization and increases its enzymatic activity.

15 oint mutations in ASH1L cause defects in its enzymatic activity.

16 n in myofibroblasts that is unrelated to its enzymatic activity.

17 eptible to spontaneous unfolding and loss of enzymatic activity.

18 er, independent kinetic parameters of HLA-DM enzymatic activity.

19 observed in firmness evolution according to enzymatic activity.

20 have the potential to saturate gut bacterial enzymatic activity.

21 uires two other subunits, EED and SUZ12, for enzymatic activity.

22 wo new chemical scaffolds that inhibit Notum enzymatic activity.

23 vely interrogate minor, subcellular pools of enzymatic activity.

24 ied by changes in intracellular pH level and enzymatic activity.

25 requires the core shell protein VP2 for its enzymatic activity.

26 ), and ENO2 Cys(346) residues affected their enzymatic activity.

27 t HSD17B13 plays a role in NAFLD through its enzymatic activity.

28 modification dramatically inhibits ADAMTS13 enzymatic activity.

29 mic regulatory mechanisms that control their enzymatic activity.

30 assembly of this complex is integral to its enzymatic activity.

31 ectly to the E3 ligase without affecting its enzymatic activity.

32 ALDOA promoted metastasis independent of its enzymatic activity.

33 ine diphosphate ribose as a biomarker of TIR enzymatic activity.

34 occurring P260S mutation all confer loss of enzymatic activity.

35 RI approach to detect acid phosphatase (AcP) enzymatic activity.

36 on, with a mechanism that up-regulates NAMPT enzymatic activity.

37 uncouples protein accumulation from loss of enzymatic activity.

38 les, concentration being likely dependent on enzymatic activity.

39 degeneration that contributes to TIR domain enzymatic activity.

40 The absence of Tim50 or its mutation reduced enzymatic activity.

41 t mutations in C. rubella, causing a loss of enzymatic activity.

42 by USP11 gene silencing or the inhibition of enzymatic activity.

43 c venules and that this is dependent on PAD4 enzymatic activity.

44 the contributions of specific amino acids to enzymatic activity.

45 etermining segment were required for optimal enzymatic activity.

46 r impair UGDH stability, oligomerization, or enzymatic activity.

47 and reduced hepatic glutamate dehydrogenase enzymatic activity.

48 pulmonary delivery while preserving its full enzymatic activity.

49 tails, epigenetic enzymes, and modulators of enzymatic activity.

50 effects of post-translational regulation on enzymatic activity.

51 pponbare NOMT as the main cause of the lower enzymatic activity.

52 olding effect of Aldob is independent of its enzymatic activity.

53 to NPCs occurred after Rad51 loading and its enzymatic activity.

54 ction process of H(2)O(2) liberated from the enzymatic activity.

55 Bs-FtsZ assembly and as an auto-inhibitor of enzymatic activity.

56 bearing the Y15A or Y15G substitutions lack enzymatic activity.

57 ong been appreciated as a major regulator of enzymatic activities.

58 Rhodopseudomonas palustris, enhancing their enzymatic activities.

59 on-catalytic functions that overshadow their enzymatic activities.

60 de these compounds than reflected by initial enzymatic activities.

61 and most notably, with substantial shifts in enzymatic activities.

62 esis, indicating impairment of PLP-dependent enzymatic activities.

63 , de novo drug design, immune responses, and enzymatic activities.

64 ctions with commensurate modulation of their enzymatic activities.

65 phase assays and effectively inhibited their enzymatic activities.

66 linked mutations are known to influence both enzymatic activities.

67 hway activation reduces ROS generated by QR2 enzymatic activity, a process that alters the intrinsic

68 The order of enzymatic activity across Golgi cisternae is essential f

69 neuronal nitric oxide synthase (nNOS), nNOS enzymatic activity, activation of MK2 (MAPK-activated pr

70 e centrifugation retained 83% of its initial enzymatic activity after 15 reuse cycles.

71 for the maximal activation of HOIP and MALT1 enzymatic activity after cofactor recruitment to CARD11.

72 upplementation was able to increase specific enzymatic activity along with reduction in H(2)O(2) in t

73 Inhibition of CYP1A1 enzymatic activity ameliorated the skin immunopathology

74 sing biochemical approaches, we examined BER enzymatic activities and their influence on TNR R-loops.

75 eletal muscle were deficient in Gaa mRNA and enzymatic activity and accumulated high levels of glycog

76 their EPR hyperfine coupling constants upon enzymatic activity and are selective to lipases were dev

77 rved increased ornithine decarboxylase (ODC) enzymatic activity and concentration of its product, put

78 iency (MSD) displayed a clear deficit in the enzymatic activity and could be completely distinguished

79 f telomerase, hTR, simultaneously inhibiting enzymatic activity and delivering radiation intracellula

80 s coupling determines substrate affinity and enzymatic activity and explains the activities of CB-839

81 owth with the iron-only nitrogenase, but its enzymatic activity and function are unknown.

82 observed that this ELANE mutation diminishes enzymatic activity and granulocytic differentiation with

83 xpression was correlated with a reduction in enzymatic activity and impaired N-glycan branching.

84 s translational response indicates that Ded1 enzymatic activity and interaction with eIF4G1 are requi

85 his S559 phosphorylation of RRM1enhances RNR enzymatic activity and is required for maintaining suffi

86 rk; mitochondrial size & number; Drp1 GTPase enzymatic activity and mitochondrial respiration (1) in

87 ious advantages, such as external control of enzymatic activity and noninvasiveness.

88 targeting CDK6 with PROTACs that inhibit its enzymatic activity and promote its degradation represent

89 in myeloid cells that is independent of its enzymatic activity and promotes type I immunity by promo

90 This process confers enzymatic activity and reduces access to noncanonical, a

91 entation and enzymatic assays, show impaired enzymatic activity and severely reduced NAD levels.

92 s, to identify regulatory mechanisms for its enzymatic activity and subcellular localization.

93 isrupt its oligomerization and cause loss of enzymatic activity and translocation from the nucleolus

94 Olaparib inhibits PARP1/2 enzymatic activity and traps PARP1 on DNA at single-stra

95 ng of Cytokinin Oxidase 2 (CKX2) affects its enzymatic activity and, thereby, determines the degradat

96 cal properties (e.g., analyte concentration, enzymatic activities, and protein-protein interactions)

97 2(A182D) permit residual protein expression, enzymatic activity, and normal numbers of neutrophils an

98 binding of telaprevir potently inhibits its enzymatic activity, and using drug resistance selection,

99 Their enzymatic activities are stimulated by a regulatory prot

100 PARP-1 and its enzymatic activity are key regulators of rDNA transcript

101 Indeed, both NOMT expression and NOMT enzymatic activity are lower in Kasalath than in Nipponb

102 presence of unfrozen water favoured various enzymatic activities as shown by a pH decrease, indicati

103 In this study, we identify CYP1A1 enzymatic activity as a critical regulator of beneficial

104 t of cGAS contributes to enhancement of cGAS enzymatic activity as a result of DNA-induced liquid-pha

105 show that BB0270 has a similar structure and enzymatic activity as its counterparts from other bacter

106 N acetylation and deacetylation regulate its enzymatic activity as well as levels of mature hTR.

107 rrespondingly altered copper binding and the enzymatic activity, as well as intracellular Cu(1+) abun

108 In vitro enzymatic activity assays indicated an increase in the p

109 o address this gap in knowledge, we measured enzymatic activity associated with the proteasome (chymo

110 ence of Ctf4, a protein that coordinates the enzymatic activities at replication forks.

111 (424)RSKK to ASGA), which did not affect its enzymatic activity, blocked nuclear NAMPT transport, slo

112 led how acetylation of PARN can decrease its enzymatic activity both in vitro, using a synthetic RNA

113 different steam blanching conditions on the enzymatic activity, browning and protein degrading which

114 We propose the labeling of enzymatic activities by chemical probes as a generalizab

115 istic explanation for inhibition of the PSMA enzymatic activity by A9g as well as its ligand-selectiv

116 a paradigm for the coordinate regulation of enzymatic activity by simultaneous allosteric inputs.

117 ically associate with others and cooperative enzymatic activity can coevolve, leading to the evolutio

118 into a lasso peptide structure requires two enzymatic activities: cleavage of the precursor via a cy

119 tion of the AHR pathway and increased CYP1A1 enzymatic activity compared with healthy donors, suggest

120 These variants, which reduce or abolish enzymatic activity, confer a spectrum of disease risk, f

121 The TG enzymatic activities considered in our discussion of hum

122 utrophil influx into the lungs, and that Pla enzymatic activity contributes to bacterial resistance t

123 cate that the R882H mutation compromises the enzymatic activity, CpG specificity and flanking sequenc

124 enzymes and in facilitating the emergence of enzymatic activity de novo on scaffolds that were previo

125 As Adgf-A expression and its enzymatic activity decrease following tissue damage, our

126 ates complex I subunit protein abundance and enzymatic activity, decreases reactive oxygen species pr

127 s retinol dehydrogenase (RDH) activity, with enzymatic activity dependent on lipid droplet targeting

128 hod for assaying the spatial distribution of enzymatic activity directly from tissue.

129 the only activity of viperin that links its enzymatic activity directly to an antiviral mechanism in

130 none oxidoreductase, Mtln does not alter its enzymatic activity directly.

131 Impairment of PRC1 enzymatic activity does not directly disrupt these inter

132 the entire N-terminus but lacking an intact enzymatic activity domain We further identified RPS2 as

133 tually exclusive, readers often also exhibit enzymatic activity (dual-function EM genes).

134 known about the consequences of blocking its enzymatic activity during embryonic development.

135 the shuttling factors) or provide additional enzymatic activities (e.g., Parkin) to proteasomes, but

136 We found that ARTD1, but not its enzymatic activity, enhanced the transcriptional activat

137 Here, we show that C45's enzymatic activity extends to the efficient and stereose

138 hylated CpG dinucleotides of DNA and through enzymatic activities for DNA methylation and/or chromati

139 The technique may be tailored to evolve enzymatic activity for a variety of transformations wher

140 variant protein has both significantly lower enzymatic activity for both interconversion reactions an

141 n of the HSV1-tk gene (sr39tk) with improved enzymatic activity for ganciclovir.

142 This work reveals novel enzymatic activity for SidI and provides insight into ho

143 tional dynamics both in the evolution of new enzymatic activities from existing enzymes and in facili

144 both DNMT3A and DNMT3B and stimulating their enzymatic activities, genetic evidence suggests that DNM

145 pair of base lesions generally requires five enzymatic activities: glycosylase, endonuclease, lyase,

146 gues with hydrolases like arylsulfatases, no enzymatic activity has been previously reported for YejM

147 MIF enzymatic activity has been used for identification of M

148 However, inhibitors of EZH2 enzymatic activity have not shown the expected efficacy

149 es of ABS were applied for measuring general enzymatic activity; however, a recent focus has been pla

150 hat the conformational states of Lck control enzymatic activity; however, the underlying principles o

151 ee competing interests: (i) maintaining high enzymatic activity, (ii) ensuring good long-term stabili

152 ation studies of inflammasome components and enzymatic activity impossible.

153 ely combines both deacetylase and remodeling enzymatic activities in a single macromolecular complex.

154 cellular copper levels and copper-dependent enzymatic activities in both organelles.

155 re we report the first multiplex assay of 10 enzymatic activities in dried blood spots and fibroblast

156 vents at endogenous genomic loci to cellular enzymatic activities in human and mouse cell lines and o

157 sitive quantitative methods to measure their enzymatic activities in mice intranasally challenged wit

158 hosphatase with dual SAC1 and 5'-phosphatase enzymatic activities in regulating phospholipid signalin

159 Decreased TET enzymatic activities in the brains of persons who died w

160 i-tryptase antibody potently blocks tryptase enzymatic activity in a humanized mouse model, reducing

161 f oxidase molecules displaying a spectrum of enzymatic activity in CNT/E films ranging from voltammet

162 e orthologues effectively modulate complex I enzymatic activity in mouse and human cells, respectivel

163 avel roles in regulating meiosis, beyond its enzymatic activity in poly(ADP-ribose) catabolism.

164 que that enables non-invasive measurement of enzymatic activity in real time in living organisms.

165 n still associate with the membrane and have enzymatic activity in reconstituted systems after trunca

166 ted by chronoamperometrically monitoring the enzymatic activity in the absence and in the presence of

167 This led to reduced FAH protein levels and enzymatic activity in the liver and kidney (but not the

168 expressing Cyp1a1 displayed increased CYP1A1 enzymatic activity in the skin, which resulted in exacer

169 r the easy, fast, and efficient detection of enzymatic activity in turbid media, the properties of th

170 with SBI-0206965, potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the vi

171 Mdm2 directly binds parkin and enhances its enzymatic activity in vitro and in intact cells.

172 rgeting chimeras (PROTACs) that inhibit CDK6 enzymatic activity in vitro, promote the rapid and prefe

173 With the genotypic restoration of PagP enzymatic activity in Yp, a significant increase in lipi

174 In the absence of enzymatic activity, increase in the TR-FRET signal betwe

175 Assaying for enzymatic activity is a persistent bottleneck in biocata

176 GlcNAc in alpha(1,6)-linkages, suggest that enzymatic activity is controlled by distinct open and cl

177 Enzymatic activity is crucial for various technological

178 These findings demonstrate that TREX1 enzymatic activity is crucial to prevent inappropriate D

179 TIR enzymatic activity is induced by pathogen recognition an

180 Inhibition of the enzymatic activity is not a result of hindrance of subst

181 Protein convertase enzymatic activity is required for PD-1 expression on T

182 However, KDM6A enzymatic activity is required in certain cellular conte

183 ransition is a fundamental switch in the GDH enzymatic activity. It introduces a torsional stress, an

184 wed that they directly resulted in decreased enzymatic activity, leading to significant reduction in

185 The binding of DNA to cGAS activates its enzymatic activity, leading to the synthesis of a second

186 at phosphorylation-dependent control of TAA1 enzymatic activity may contribute to regulation of auxin

187 using a strong but not complete reduction of enzymatic activity, may therefore result in an intermedi

188 Assays showed acceptable precision, and enzymatic activities measured in confirmed MPS samples a

189 Soluble CD73 (sCD73) enzymatic activity measured in patient serum or plasma a

190 Current methods for enzymatic activity measurement often suffer from low ana

191 Although PRMT5 does not directly affect PRC2 enzymatic activity, methylation of histone H3 by PRMT5 a

192 rgence of these microbe communities or their enzymatic activities might be used to reduce the risk of

193 The ~250-kDa L possesses all enzymatic activities necessary for its function but requ

194 broad and potent capacity to inhibit IBV NA enzymatic activity, neutralize the virus in vitro, and p

195 such factors revealed that although multiple enzymatic activities never coexist within a single compo

196 These systems incorporate enzymatic activities not previously implicated in antivi

197 phosphoprotein (P), catalyzes three distinct enzymatic activities - nucleotide polymerization, cap ad

198 mitochondrial dynamics and biogenesis genes; enzymatic activities of ETC complexes I, II, III and IV;

199 he N-RNA template and coordinate the various enzymatic activities of L.

200 LG2, which increased succinate synthesis and enzymatic activities of mitochondrial nucleoside diphosp

201 a SEDS-bPBP complex can coordinate its dual enzymatic activities of peptidoglycan polymerization and

202 trafficking to the vacuole regulated by the enzymatic activities of PI4KIIIbeta1 and PI4KIIIbeta2 pa

203 Notably, however, the two enzymatic activities of PNKP appear to affect different

204 The enzymatic activities of PrimPol are critically dependent

205 ree noncatalytic subunits optimizes the dual enzymatic activities of the catalytic p261 subunit and m

206 The enzymatic activity of 1 is photoregulated which offers o

207 We also measured the enzymatic activity of 1.56 x 10(5) molecular variants of

208 tose and 0.17 or 0.19 mol/kg lactose with an enzymatic activity of 2.0 or 2.8 mukat/kg for acid (pH 4

209 al. present results that explain the reduced enzymatic activity of a common genetic variant of the en

210 igated how this interaction would affect the enzymatic activity of ACE2.

211 he active site, this molecule attenuates the enzymatic activity of ADA and inhibits proliferation of

212 pA versus RA together with a decrease in the enzymatic activity of ADAM17.

213 assays of the films revealed the lowering of enzymatic activity of all four oxidases by CNT.

214 es within the disordered CTT to assembly and enzymatic activity of Bacillus subtilis FtsZ (Bs-FtsZ).

215 nger trigger HR, thereby suggesting that the enzymatic activity of Bs3 is crucial to Bs3-triggered HR

216 olysulfides strongly and rapidly inhibit the enzymatic activity of caspase-3, a major effector protea

217 The enzymatic activity of CitA is dispensable for CtrA contr

218 y, we report for the first time the in vitro enzymatic activity of EV-D68 2A(pro) and the identificat

219 ally, the swst mutation had no effect on the enzymatic activity of FAH, but rather promoted the degra

220 that recifin A can specifically modulate the enzymatic activity of full-length TDP1 while not affecti

221 the active intracellular domain requires the enzymatic activity of gamma-secretase.

222 The structures and available data suggest an enzymatic activity of HeR-48C12 subfamily and their poss

223 emingly disparate observations regarding the enzymatic activity of hGGT1 mutants.

224 The enzymatic activity of human ALAD is greatly reduced upon

225 parated to enable effective tracking of each enzymatic activity of interest.

226 modulate cytotoxic LLO activity through the enzymatic activity of its PC-PLC.

227 ctical high-throughput system to measure the enzymatic activity of kinases using biological peptide t

228 The structure and enzymatic activity of modified proteins remain conserved

229 Here, we monitor the enzymatic activity of p97 in real time via an NMR-based

230 t a small molecule PARP1 degrader blocks the enzymatic activity of PARP1 without eliciting PARP1 trap

231 residues S295 and S314, which activates the enzymatic activity of PDHc and alleviates an inhibitory

232 The p.Glu396Lys variant increased the enzymatic activity of PLCdelta1, leading to protein kina

233 phenols, betalains, antioxidant capacity and enzymatic activity of polyphenol oxidase (PPO) and pheny

234 Together, these findings suggest that the enzymatic activity of PPAD is not a major virulence mech

235 , lower mitochondrial respiration, decreased enzymatic activity of pyruvate dehydrogenase (PDH), and

236 ith PN also induced a 7-fold increase in the enzymatic activity of RALDH2.

237 e in planta presence of 4E02 does not impede enzymatic activity of RD21A.

238 tin ligase activity of RLIM, suggesting that enzymatic activity of RLIM is required for normal develo

239 recognition events and are regulated by the enzymatic activity of sialyltransferases and neuraminida

240 copy, we provide detailed information on the enzymatic activity of silicatein, its crystallization, a

241 were the most potent DHAs and increased the enzymatic activity of SIRT6 without showing any signific

242 s report we show that the expression and the enzymatic activity of the gammaherpesvirus-encoded conse

243 dditionally, we screened their effect on the enzymatic activity of the histone deacetylase sirtuin fa

244 However, enzymatic activity of the RVP domain has not yet been de

245 e (corn, Zea mays) specifically inhibits the enzymatic activity of the secreted chorismate mutase Cmu

246 inery restored virulence to a strain lacking enzymatic activity of the three phosphodiesterases.

247 ent genes and forming a complex in which the enzymatic activity of the toxin is inhibited.

248 We found that phosphorylation enhances enzymatic activity of these proteins, creating a negativ

249 ight constitute an element of importance for enzymatic activity of this and possibly other proteins.

250 chromatography-mass spectrometry screen for enzymatic activity of this orphan protein.

251 g agents and crowder-concentration-dependent enzymatic activity of transcription factors.

252 posomal calcium ions, which then trigger the enzymatic activity of transglutaminase.

253 cell cycle arrest is dependent on the intact enzymatic activity of translocated substrates that inhib

254 actose and fructose concentration as well as enzymatic activity of two commercially available beta-ga

255 in the Nudix motif impaired or abolished the enzymatic activity of YvcI.

256 Although the enzymatic activity of ZikV-NS5 appears to be dispensable

257 Monitoring these enzymatic activities offers valuable diagnostic tools.

258 oexist within a single component, individual enzymatic activities often coexist with a reader domain.

259 olipases, we investigate the effect of their enzymatic activities on LLO.

260 ilized the genome due to (i) partial loss of enzymatic activity (P27S or H50Y), (ii) a nonsense mutat

261 tractive concept, since tumor cells may lack enzymatic activities present in normal constitutional ce

262 ally, there is need to go beyond just target enzymatic activity profiling to establishing cellular ac

263 e antibodies also inhibit neuraminidase (NA) enzymatic activity, prohibiting viral egress.

264 Here, we find that cells lacking RAD51's enzymatic activity protect replication forks from MRE11-

265 gands are integrated to coordinately control enzymatic activity remains poorly understood.

266 GFPT modification by TG2 increases its enzymatic activity, resulting in higher levels of UDP-N-

267 l, and the rates, spectra and progression of enzymatic activities, reveal robust differences among di

268 efined the mechanisms for response regulator enzymatic activities, revealed trends in regulatory stra

269 cannot interact with SSB but that maintains enzymatic activity (rnhAK60E) eliminates RNase HI foci.

270 on to selectively target complex patterns of enzymatic activity should be useful in disease detection

271 s research complemented with results on BIA1 enzymatic activities shows that the enzyme regulates bra

272 In the absence of perforin, we show that GrB enzymatic activity still induces substoichiometric activ

273 eme binding had only a modest effect on SbnI enzymatic activity, suggesting that its two functions ar

274 ral 2-amino-benzo[ d]thiazoles with improved enzymatic activity ( TbPTR1 IC(50) = 0.35 muM; LmPTR1 IC

275 falciparum Clp protease (PfClpP) has robust enzymatic activity that is essential for apicoplast biog

276 vels of DNA methylation result from opposing enzymatic activities, the rates of which remain largely

277 Polymerization inhibits enzymatic activity; the Glk1 monomer-polymer equilibrium

278 s cooperative mechanism and leads to reduced enzymatic activity, thus explaining the genomic hypometh

279 irected mutagenesis of this arginine reduced enzymatic activity to <3% of the WT levels.

280 hat these phosphoinositides activate ADAP1's enzymatic activity to catalyze GTP hydrolysis by ARF6.

281 therapy; however, in vivo remote control of enzymatic activity to improve their therapeutic specific

282 uide the design of diagnostics that leverage enzymatic activity to measure or produce biomarkers of d

283 etal ion activators that greatly promote the enzymatic activities (up to 251 %).

284 n ultrasensitive method for the detection of enzymatic activity using Single Molecule Arrays (eSimoa)

285 No enzymatic activity was detected for ABA4 and NXD1 protei

286 determined using six different assays while enzymatic activity was determined by alpha-amylase and t

287 Conversely to zones firmness, enzymatic activity was higher in pistil followed by equa

288 igested in simulated gastric fluid and their enzymatic activity was inhibited upon heat treatment.

289 Caspase-8 enzymatic activity was necessary for maximal expression

290 Of note, ExoY enzymatic activity was not required for F-actin bundling

291 uisite for structure-guided investigation of enzymatic activity, we determine here the crystal struct

292 luate the effects of these variants on ADAR2 enzymatic activity, we performed in vitro assays with re

293 supercomplexes were destabilized, and OXPHOS enzymatic activities were reduced in AR-expressing cells

294 onal and bioactive properties as well as key enzymatic activities were studied in sprouted oat powder

295 HN3-T20 retained 73% enzymatic activity when compared with the wild-type immu

296 s been fueled by recent correlations of this enzymatic activity with cardiovascular, neurological, an

297 estion temperature, in order to optimize the enzymatic activity, with a special emphasis on sialylate

298 ecting the other biological functions of TET enzymatic activities without affecting their other nonen

299 leotide-binding site of this domain modulate enzymatic activity without significantly affecting hGMPK

300 VP2 is critical for VP1 enzymatic activity; yet, the mechanism by which the core