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1 all domains of life, 54 structures, and >10 enzymatic functions).
2 on SARM1 and the discovery of its intrinsic enzymatic function.
3 examining how protein dynamics contribute to enzymatic function.
4 all molecule MIF inhibitors antagonize MIF's enzymatic function.
5 and in vitro assays confirmed their proposed enzymatic function.
6 e directed probes are powerful in studies of enzymatic function.
7 sequence signatures to automatically predict enzymatic function.
8 werful attribute space for the prediction of enzymatic function.
9 anding the structural bases for evolution of enzymatic function.
10 rization of mutant Top2 monomers can restore enzymatic function.
11 nd catalytic flexibility in the evolution of enzymatic function.
12 pterin (BH4) is essential for maintenance of enzymatic function.
13 lay important roles in protein structure and enzymatic function.
14 -halophenols in the internal pocket inhibits enzymatic function.
15 oxicity of the protein rather than a loss in enzymatic function.
16 ties of normal and disease-associated mutant enzymatic function.
17 y defuse conformational strain, and preserve enzymatic function.
18 ation of p21 possibly independent from COX-2 enzymatic function.
19 n has a key role in the control of sulfatase enzymatic function.
20 nsmembrane domain was also required for full enzymatic function.
21 T2 demonstrated that it is required for full enzymatic function.
22 of key amino acids that likely contribute to enzymatic function.
23 important regulator of nitric oxide synthase enzymatic function.
24 thiamin phosphate synthase, it has no known enzymatic function.
25 r acts as both agonist and antagonist to the enzymatic function.
26 ll species and link a protein sequence to an enzymatic function.
27 mate linkage between protein flexibility and enzymatic function.
28 here is a general link between structure and enzymatic function.
29 lution and performed a series of screens for enzymatic function.
30 imilarity in sequence implying similarity in enzymatic function.
31 nicity of Bla g 2 was linked to its putative enzymatic function.
32 with respect to its secondary structure and enzymatic function.
33 of charge in these systems may contribute to enzymatic function.
34 omodimers, and dimerization is essential for enzymatic function.
35 amounts of DOPE, and correlate with enhanced enzymatic function.
36 e deacetylase complex are required for their enzymatic function.
37 rofound effect on TARS protein stability and enzymatic function.
38 ed our understanding of how mutations impact enzymatic function.
39 blocks MLCK1 recruitment without inhibiting enzymatic function.
40 host coevolution has required adaptations of enzymatic function.
41 e perinuclear area, insolubility and loss of enzymatic function.
42 sialidase activity and fulfills a purely non-enzymatic function.
43 ying mutation and magnitude of its effect on enzymatic function.
44 ey amino acids that likely contribute to its enzymatic function.
45 a bypass of RscS's own HPt domain and SypF's enzymatic function.
46 ire intermediates of cellular metabolism for enzymatic function.
47 lpha-tubulin revealed that propofol inhibits enzymatic function.
48 ence mirrors categorization of the family by enzymatic function.
49 evolutionary trajectories creating a nascent enzymatic function.
50 NBC malignancy through its enzymatic and non-enzymatic functions.
51 h lysine carbamylation as well as subsequent enzymatic functions.
52 of phylogenetic analysis to predict possible enzymatic functions.
53 on signal, which seemed irrelevant for other enzymatic functions.
54 virus assembly was independent of its known enzymatic functions.
55 ute to biochemical weathering in addition to enzymatic functions.
56 ve mechanisms that led to diversification of enzymatic functions.
57 t required for RNase E to carry out its core enzymatic functions.
58 hips and enhance the mechanistic analysis of enzymatic functions.
59 pear to have wall-loosening, structural, and enzymatic functions.
60 ts and proteins with distinct structural and enzymatic functions.
61 of the rat liver NDANST to localize the two enzymatic functions.
62 zymes, whereas others perform entirely novel enzymatic functions.
63 e activities and inhibits alt-NHEJ using non-enzymatic functions.
64 ells and is required for many structural and enzymatic functions.
65 ymes, resulting in the inactivation of their enzymatic functioning.
66 r identification of residues (1) involved in enzymatic function, (2) forming short linear functional
69 res in mitochondria, whereas mutants lacking enzymatic function (a(-)D(+)) show a reticular distribut
70 not result in an observable defect in SETD2 enzymatic function, a second mutation in the catalytic d
71 acetylcholinesterase responsible for its non-enzymatic functions, a thirty amino acid peptide ("T30")
72 ke R109K, which had minimal impact on NS3/4A enzymatic function, A156T significantly reduced NS3/4A c
73 s results suggest the strong conservation of enzymatic function above levels of 50% pairwise sequence
74 ere is clear evidence for repeated shifts in enzymatic function among duplicate copies of CHS genes.
75 uggesting that SAPHIRE has both an important enzymatic function and an essential nonenzymatic functio
76 anocircuits allowed electrical recordings of enzymatic function and dynamic variability with the reso
77 arization for quantitative interpretation of enzymatic function and for calculation of binding free e
78 fied an antibody inhibitor (AB0023) of LOXL2 enzymatic function and have found that the inhibition oc
79 N 273) resulted in incremental diminution of enzymatic function and infectivity and that removal of t
80 and functions as a tumor suppressor via its enzymatic function and multiple protein-protein interact
82 served as intermediates in the evolution of enzymatic function and opens the path for the developmen
83 molecular mechanisms leading to the loss of enzymatic function and retinal degeneration remain poorl
85 n all-or-nothing transition in regard to the enzymatic function and thus must be surveyed carefully.
86 ge (L) protein that catalyzes three distinct enzymatic functions and an essential coenzyme phosphopro
87 nicotinamide adenine dinucleotide for their enzymatic functions and are therefore readily accessible
88 ed in germin-like proteins (GLPs) with other enzymatic functions and characteristic for proteins depo
89 at evaluates the in vivo context of in vitro enzymatic functions and confirms the functional predicti
90 of ~96%, PtAADC1 and PtAAS1 showed different enzymatic functions and converted Phe into 2-phenylethyl
94 suggest that this role is distinct from its enzymatic functions and requires interaction with the vi
95 mputational models specific for 939 distinct enzymatic functions and, when data is sufficient, their
96 the top 50 out of 5594 candidates for their enzymatic function, and 70% of metabolic genes whose exp
98 ultiple functions, including redox activity, enzymatic function, and maintenance of structural integr
99 e DNA conformational changes associated with enzymatic function, and may reflect a general biological
100 lent and its subsequent oxidation is a novel enzymatic function, and one that dominates the oxygenase
102 homozygous G6PC3 G260R mutations, a loss of enzymatic function, and typical syndrome features with t
103 including both enzymes and proteins with non-enzymatic functions annotated by Gene Ontology (GO) term
105 these genes reveals that although individual enzymatic functions are always mutually exclusive, reade
108 sults suggest a worsening of vitamin B(12)'s enzymatic functions as folate status increases in people
109 hibitor of HCV NS5A, a protein with no known enzymatic function, as an approach to the suppression of
110 te of the cluster play a crucial role in the enzymatic function, as these atoms are directly involved
114 ndicating that ATAC2 not only carries out an enzymatic function but also plays an architectural role
115 cell nuclear antigen (PCNA) has no intrinsic enzymatic function, but functions as a sliding platform
116 erved architecture that supports a myriad of enzymatic functions, but also a conserved folding mechan
118 o dramatically restore protein stability and enzymatic function by manipulation of the cellular chape
120 thogenic missense mutations in proteins with enzymatic function can be overcome in some cases by enha
121 ndings show that two proteins with a similar enzymatic function can have opposing roles in the contex
123 ATP hydrolysis appears to be a nonoptimized enzymatic function, closer analysis of this remarkable p
124 software makes 142 additional assertions of enzymatic function compared with a recent annotation pac
126 one acetyltransferase activity and that this enzymatic function contributes to chromatin-remodelling
127 fs characteristic of copper oxidases, and no enzymatic function could be assigned to the SKU5 protein
128 ve significant deaminase activity, but their enzymatic function could be restored by subsequent incub
130 ly generated sequences correspond to ancient enzymatic functions, e.g., glycolysis, replication, and
133 RC2) promotes oncogenesis partly through its enzymatic function for inducing trimethylation of histon
135 idation, suggesting a convergence toward the enzymatic function for methanol oxidation in MxaF and Md
136 rovides a general method for photocontrol of enzymatic function for proteins having a significant pH-
137 2'-O-acetyl-ADP ribose by sir2p and Sir2p's enzymatic function for silencing can be bypassed in a su
138 we identified candidate genes with predicted enzymatic functions for the conversion of sabinene to al
139 Herein, we report the emergence of proto-enzymatic function from recursive polymerisation reactio
143 effectors that mediate refolding and enhance enzymatic function have the potential to improve the tre
144 he same dataset) over proteins with the same enzymatic function (identical Enzyme Commission, EC, num
145 AHD2A, and FAHD2B, are known; however, their enzymatic function, if any, remains to be demonstrated.
146 indicate that NMNAT2 exerts its chaperone or enzymatic function in a context-dependent manner to main
149 dual-function protein that has a second, non-enzymatic function in complex I assembly as a plant-spec
156 Mutated p110alpha proteins show a gain of enzymatic function in vitro and are oncogenic in cell cu
157 ached, these variants affected significantly enzymatic function in vitro with variable increases in c
158 evaluated the impacts of these mutations on enzymatic function in vivo and in vitro to gain further
160 World alphaviruses, CHIKV nsP2 not only has enzymatic functions in viral RNA replication but also is
161 e that is crucial for molecular recognition, enzymatic function, information storage and structure an
162 , but possibly as a direct consequence of an enzymatic function inherent to the protein that may invo
163 lds that during evolution the structural and enzymatic functions initially served by RNA were assumed
164 early studies have focused on the canonical enzymatic functions involved in catalyzing modifications
165 f the DNA tweezer structure and actuation of enzymatic function is achieved by switching the tweezers
166 epresentation of the protein structure while enzymatic function is described by Enzyme Commission num
170 and face the periplasm, implicating that its enzymatic function is on the outer side of the plasma me
171 , and tumor suppression, indicating that the enzymatic function is required for those processes.
172 plays E3 ubiquitin ligase activity, and this enzymatic function is thought to be required for tumor s
174 ution of the Na,K-ATPase, demonstrating that enzymatic functioning is not a prerequisite for PM deliv
175 t that targeting both LIPG enzymatic and non-enzymatic functions is an important strategy for the tre
177 ature of protein structures is essential for enzymatic function, it is expected that functional evolu
178 t correlation between RNA binding and ATPase enzymatic function leading to signal transduction and su
180 strongly suggests that in human subjects RAG enzymatic function might be necessary for normal CDR3 ju
181 bjects were compared regarding mitochondrial enzymatic function, mitochondrial DNA integrity, lipid c
182 SMA is a carboxypeptidase with two important enzymatic functions, namely, folate hydrolase and NAALAD
183 ion centers are shown to have a light-driven enzymatic function; namely, the ability to convert super
184 H (RNase H) remains the only virally encoded enzymatic function not targeted by current chemotherapy
185 e results demonstrated that Tm-MazG has dual enzymatic functions, NTPase and pyrophosphatase, and tha
187 PCHM and neurodegeneration and uncover a non-enzymatic function of a spliceosomal proline isomerase.
190 ntified are predicted to severely impair the enzymatic function of ASPH, which suggests a possible li
192 BA-Stk1 kinase activity, indicating that the enzymatic function of BA-Stk1 can be influenced by BA-St
194 f UBXN1, suggesting that UBXN1 regulates the enzymatic function of BRCA1 in a manner that is dependen
197 in these cell lines suggests that the major enzymatic function of CD38 is to hydrolyze extracellular
199 d that several inhibitors known to block the enzymatic function of fibroblast activation protein-alph
200 cell surface expression of gp91phox, and the enzymatic function of flavocytochrome b558 are closely c
203 between ePY and GSH, and could be either an enzymatic function of Glx I or occur nonenzymatically at
204 rine gammaherpesvirus 68 (MHV68) retains the enzymatic function of host UNG in an in vitro class swit
205 se it is specific for LOXL2 and inhibits the enzymatic function of LOXL2 in a non-competitive manner
207 H2 inhibitors strongly suppress the enhanced enzymatic function of mutant EZH2 in some lymphomas.
210 ns and charge density can alter location and enzymatic function of peripheral membrane proteins.
211 re-function experiments to separate the dual-enzymatic function of PLCepsilon1 uncover necessary cont
212 ergo strong G(1) arrest, suggesting that the enzymatic function of PPT is essential and nonredundant.
213 ed catalytic Ado-Met binding domain, but the enzymatic function of PRMT2 with respect to methylation
214 rge hydrophilic loop region suggest that the enzymatic function of PS1/gamma-secretase can be modulat
217 study identifies a previously unappreciated enzymatic function of rapsyn and a role of neddylation i
221 In addition to inhibitors that target the enzymatic function of telomerase, efforts toward immunot
225 (PI3K)/p300 signaling and by modulating the enzymatic function of the Drosha (RNase type III) comple
227 ults for MHV-68 ORF64 are consistent with an enzymatic function of the tegument protein that is benef
229 evels of tyrosine improved the stability and enzymatic function of the Tyrc-h protein and also increa
231 link to itaconic acid production through an enzymatic function of this protein was only recently rev
232 gether, these observations rule out a direct enzymatic function of TioX and suggest that TioX is invo
235 Some of these phosphorylations support the enzymatic function of viral components, while other phos
236 he cystogenic pathways affected by disrupted enzymatic function of XPNPEP3 in cilia-related cystogeni
239 fect interactions of SARS-S with ACE2 or the enzymatic functions of cathepsin L but prevents fusion o
244 st this hypothesis we screened the potential enzymatic functions of hypothetical proteins encoded by
245 fined the sequences, tertiary structures and enzymatic functions of many of the proteins involved; fu
249 sfections with mutant genes demonstrate that enzymatic functions of the helicase-primase are not esse
251 way in mycobacteria and demonstrate that all enzymatic functions of the LigD protein participate in N
253 ply this system to regulate cytoskeletal and enzymatic functions of two non-tagged endogenous protein
255 -coordinating aspartate is essential for the enzymatic functions of XoxF MDHs and ExaF EDHs, supporti
257 a focus on understanding the impact of CD39 enzymatic function on innate and adaptive immunity and h
258 on by LPS is due to inhibition of H/K-ATPase enzymatic function or changes in cytoskeletal rearrangem
259 hereas the GTPase domain of DLP1 provides an enzymatic function, other domains contain information fo
260 ting domains, which are required for HDAC3's enzymatic function, permit normal stratification, indica
263 stablishment rate was correlated with Dot1's enzymatic function rather than with the Dot1 protein its
265 ggest that antibody allosteric modulators of enzymatic function represent a novel drug development st
266 of the mutated protein variants retained the enzymatic functions required for replication of the vira
267 lei of host epithelial cells and carries out enzymatic functions required for the initiation of viral
268 proteins of NNS RNA viruses carry all of the enzymatic functions required for viral messenger RNA (mR
269 erase and beta-glucosidase that catalyze the enzymatic functions required to avoid autotoxicity and a
270 s, but not pharmacologic inhibition of their enzymatic function, significantly attenuated the ability
271 BirA can be selectively targeted toward its enzymatic function simply by increasing the kinetic prob
274 ia coli genome, EFICAz assigns more detailed enzymatic function than KEGG, and generates numerous nov
275 ent and provide biochemical insight into its enzymatic function that may be exploited for development
276 mbrane proteins with an intrinsic additional enzymatic function that may regulate the entry of substr
277 demethylase Epe1 in fission yeast, has a non-enzymatic function that opposes heterochromatin assembly
278 f novel gene products including several with enzymatic functions that could degrade or modify the myc
279 alpha-ketoglutarate) while conferring a new enzymatic function, the production of D-2-hydroxyglutara
280 egulate proteins by transiently inactivating enzymatic function through conformational change in a di
282 that the C-terminal tail plays a role in the enzymatic function through interactions with the Ala(69)
283 ame interaction node, contribute to the same enzymatic functions through different molecular pathways
284 years ago, and has subsequently tailored its enzymatic function to human-derived thioalcohol precurso
285 50 is part of an E3 ubiquitin ligase adds an enzymatic function to the chromatin-remodeling complex S
286 share a common evolutionary ancestor, their enzymatic functions toward NAD and cADPR homeostasis hav
287 ce" genes are likely to alter cell adhesion, enzymatic functions, transcription, cell structure, and
288 zation of the Nox4-p22(phox) complex and its enzymatic function, truncation and point mutagenesis was
289 scopic characteristics are well defined, its enzymatic function, up to this point, has remained unide
290 (NA) exemplifies this concept, as it retains enzymatic function upon proteolytic release from the mem
294 cysteine residues in human APE1 affects its enzymatic function, we substituted these singly or multi
297 bidopsis ISA1 requires ISA2 as a partner for enzymatic function, whereas maize ISA1 was active by its
300 H (RNase H) remains the only virally encoded enzymatic function yet to be exploited as an antiviral t