ライフサイエンスコーパス: ependymal

1 nt of Mnb/Dyrk1A in neurons, astrocytes, and ependymal and endothelial cells appear to reflect cell t

2 OCT3-like immunoreactivity was observed in ependymal and glial-like cells in the DMH.

3 ints, we observed extensive proliferation of ependymal and periependymal cells that immunohistochemic

4 s, glia, and myelinated axon tracts but even ependymal and pial membranes.

5 Although the densities of mutant ependymal and respiratory cilia were largely normal, the

6 ponents of ciliary rootlets of multiciliated ependymal and tracheal cells.

7 xcess brain water through glial limitans and ependymal barriers.

8 nent hub genes of the gene network unique to ependymal CD133(+)/GFAP(-) quiescent cells were enriched

9 evelopmental model of IS, exhibit defects in ependymal cell cilia development and cerebrospinal fluid

10 Ultrastructural examination of the ependymal cell cilia that line the enlarged third ventri

11 r was also observed in young mice after mild ependymal cell denudation with low dosages of neuraminid

12 whether this organization is acquired during ependymal cell development or is already present in radi

13 Dystroglycan is furthermore required for ependymal cell differentiation and assembly of niche pin

14 ax is required for hypothalamic tanycyte and ependymal cell differentiation.

15 Foxj1, a transcription factor that promotes ependymal cell differentiation.

16 ependymal ciliary beat frequency and caused ependymal cell disruption.

17 involved in the regulation of EC stability, ependymal cell function, and periventricular permeabilit

18 eased expression of DIO2 in the hypothalamic ependymal cell layer containing tanycytes.

19 Furthermore, the ependymal cell layer does not form in the conditional kn

20 a role supported by the loss of cilia on the ependymal cell layer in ventricles of Tg737(orpk) brains

21 Hydin expression is confined to the ciliated ependymal cell layer lining the lateral, third and fourt

22 Before their migration through the ependymal cell layer, a subset of these infected myeloid

23 larged ventricles, partial denudation of the ependymal cell layer, altered subcommissural organ morph

24 ells infected with CVB3 migrated through the ependymal cell layer, they revealed distinct morphologic

25 Here, we show that Six3 is necessary for ependymal cell maturation during postnatal stages of bra

26 endothelium, as well as the disappearance of ependymal cell microvilli and the development of periven

27 Hypothalamic tanycytes, a radial glial-like ependymal cell population that expresses numerous genes

28 ccess to the CSF through a specialized glial/ependymal cell type, the tanycyte.

29 infant and adult human spinal cord contains ependymal cell types that resemble those present in the

30 ic genes while also inhibiting expression of ependymal cell-specific genes.

31 Aging-associated ependymal-cell pathologies can manifest as ventricular g

32 contacts between 5HT axons and NSCs (B1) or ependymal cells (E1) and these cells were labeled by a t

33 the lateral ventricular wall: a monolayer of ependymal cells (Layer I), a hypocellular gap (Layer II)

34 expression of thyroid hormone deiodinases in ependymal cells (tanycytes) of the fetal hypothalamus, a

35 between cells in both radial progenitors and ependymal cells (tissue polarity).

36 tein (BMP) antagonist Noggin is expressed by ependymal cells adjacent to the SVZ.

37 Timely generation and normal maturation of ependymal cells along the aqueduct are critical for prev

38 or for generating developmentally controlled ependymal cells along the ventricular lining of the aque

39 It has been suggested that ependymal cells also function as stem cells.

40 get genes to regulate the differentiation of ependymal cells and a small subset of astrocytes in the

41 in mice is required for differentiation into ependymal cells and a small subset of FoxJ1(+) astrocyte

42 icular zones of the brain differentiate into ependymal cells and astrocytes.

43 In conclusion, loss of ependymal cells and ciliary function exposes the underly

44 birth and early stages in the maturation of ependymal cells and demonstrates that these cells are de

45 patch clamp single motile cilia of mammalian ependymal cells and examine their potential function as

46 by astrocytes in the adult brain except for ependymal cells and in the neurogenic regions, where SOX

47 ments reveal that they also make astrocytes, ependymal cells and interneurons.

48 Het CKO mice had decreased ependymal cells and Mpp5 at the apical surface of cortic

49 The fused gene is expressed highly in ependymal cells and the choroid plexus, tissues involved

50 terestingly, we found that the maturation of ependymal cells and the formation of cilia occur signifi

51 Our results indicate that ependymal cells are born in the embryonic and early post

52 Most ependymal cells are born prenatally and are derived from

53 localized to the ependyma, although not all ependymal cells are CD133(+).

54 Ependymal cells are functionally heterogeneous with a mi

55 Ependymal cells are generated from radial glia cells dur

56 Ependymal cells are LeX(-), and purified ependymal cells

57 ells in the alpha2 tanycytic zone, where few ependymal cells are normally found, suggesting that Rax

58 Ependymal cells are part of the neurogenic niche in the

59 Our findings suggest that connexins in ependymal cells are potential targets to improve self-re

60 , and a late phase, in which only additional ependymal cells are produced.

61 results suggest that PCNA and late dividing ependymal cells are required for normal CNS development

62 erneurons in laminae I and II, as well as in ependymal cells around the central canal.

63 types of astrocytes and a group of displaced ependymal cells between Layers II and III.

64 icate that, unlike cuboidal ependymal cells, ependymal cells bordering the CVOs possess long processe

65 ephalus or prevent the formation of ciliated ependymal cells but caused defects in their differentiat

66 the developmental origin of postnatal spinal ependymal cells by studying the dynamic expression of se

67 Our data show that ependymal cells can serve as a source of enzyme secretio

68 ing approaches, we demonstrate that CD133(+) ependymal cells continuously produce new neurons destine

69 with increased KLF4 in NSCs and NSCs-derived ependymal cells developed hydrocephalus-like characteris

70 l ventricles, and uniciliated and biciliated ependymal cells display cilia with large, star-shaped ba

71 Ependymal cells are LeX(-), and purified ependymal cells do not make neurospheres, resolving the

72 o the ventricular surface of differentiating ependymal cells during FoxJ1-dependent ciliogenesis.

73 CC lining serves as a source of cells beyond ependymal cells during the first postnatal weeks of the

74 The homeobox gene Six3 is expressed in ependymal cells during the formation of the lateral wall

75 trocytes, Iba-1(+) microglia and S100beta(+) ependymal cells expressed PLIN in the aging brain.

76 In its absence, ependymal cells fail to suppress radial glia characteris

77 ntricle-contacting NSCs, which together with ependymal cells form regenerative units (pinwheels) alon

78 S100B+/PV+ ependymal cells found in younger mice diminished in the

79 cal characteristics similar to multiciliated ependymal cells from the lateral ventricles, and unicili

80 Ependymal cells have a remarkable planar polarization th

81 In addition, we suggested that the Nkx6.1+ ependymal cells in adult mouse spinal cords may retain t

82 This suggests an involvement of PV+ ependymal cells in aging-associated ventricle stenosis.

83 PV and display phenotype shift to "reactive" ependymal cells in aging-related ventricle stenosis; mor

84 ia of respiratory epithelial cells and brain ependymal cells in both mice and humans.

85 Application of 5-HT to ependymal cells in cultured rat brainstem slices caused

86 transgene, defines neurons, subependymal, or ependymal cells in discrete locations throughout the neu

87 mRNA to determine the role of late dividing ependymal cells in embryos of the ascidian Styela clava.

88 also observed in some endothelial cells and ependymal cells in HIVE CNS.

89 cell niche to repair.SIGNIFICANCE STATEMENT Ependymal cells in the adult spinal cord are latent prog

90 ver, GFP expression persisted in a subset of ependymal cells in the adult spinal cord, suggesting tha

91 ncy also resulted in the ectopic presence of ependymal cells in the alpha2 tanycytic zone, where few

92 d choroid epithelial cells diminished, while ependymal cells in the lateral and fourth ventricles sho

93 Here we show that basal bodies in ependymal cells in the lateral ventricle walls of adult

94 16 is required for the formation of ciliated ependymal cells in the lateral ventricle.

95 However, PV+ ependymal cells in the LV-wall adhesions, unlike injury-

96 We find that coupling among ependymal cells is downregulated as postnatal developmen

97 Ciliated ependymal cells line the ventricular surfaces and aquedu

98 Ependymal cells lining the brain ventricles also carry m

99 ventricles depends on cilia motility of the ependymal cells lining the brain ventricles, which play

100 Recent studies have suggested that the ependymal cells lining the central canal of postnatal sp

101 qually distributed within microglia, and the ependymal cells lining the ventricles of the brain expre

102 icles and deceleration of ciliary beating on ependymal cells lining the ventricular walls.

103 Sox2 and Sm-Sox19 were strongly expressed in ependymal cells located in neurogenic niches revealed by

104 brains of adult C57BL/6 mice and found that ependymal cells located in the adhesions of the medial a

105 (Sm-Sox2) and Sm-Sox19 mRNAs was detected in ependymal cells of different regions of the telencephalo

106 fects in the motile cilia of the ventricular ependymal cells of mutants, suggesting a role for Katnal

107 Our findings implicate that compromised ependymal cells of the adhering ependymal layers upregul

108 These biciliated ependymal cells of the central canal (Ecc) resembled E2

109 retinoic acid (RA) within the tanycytes and ependymal cells of the hypothalamus have been implicated

110 cause Noggin expression is restricted to the ependymal cells of the lateral ventricles, where FXR2 is

111 GLUT2 immunoreactivity was seen in the ependymal cells of the third ventricle and in scattered

112 d, with Na,K-ATPase, in certain tanycytes or ependymal cells of the ventricle wall.

113 gene expression in circumventricular organs; ependymal cells of the ventricles, meninges, and choroid

114 Ependymal cells of wild-type ventricles strongly express

115 Ependymal cells on the walls of brain ventricles play es

116 for several weeks, we found no evidence that ependymal cells proliferate.

117 ental potential of the postnatal spinal cord ependymal cells remain to be defined.

118 lational polarity) in radial progenitors and ependymal cells remain unclear.

119 owever, the proliferative capacity of mature ependymal cells remains controversial, and the developme

120 expressing adult neural stem cells, CD133(+) ependymal cells represent an additional-perhaps more qui

121 Multiciliated ependymal cells show morphological characteristics simil

122 The postmitotic nature of ependymal cells strongly suggests that these cells do no

123 Finally, many ependymal cells surrounding the central canal were inten

124 epithelium of the choroid plexus and in the ependymal cells surrounding the lateral ventricles.

125 Tanycytes are highly specialized ependymal cells that form a blood-cerebrospinal fluid (C

126 HSD2 immunoreactivity was also found in the ependymal cells that form the subcommissural organ.

127 Tanycytes are highly specialized ependymal cells that line the bottom and the lateral wal

128 em cell niche is comprised of multi-ciliated ependymal cells that line the brain ventricular system a

129 ymal cells, proliferate and give rise to new ependymal cells that presumably remain in the macaque ce

130 .1 progenitor gene is constantly detected in ependymal cells throughout chick and mouse development.

131 In addition, loss of SOX9 led ependymal cells to adopt a neuroblast identity.

132 Exposure of ependymal cells to forskolin caused a decrease in CBF.

133 nexins are involved in the early reaction of ependymal cells to injury, representing a potential targ

134 Some fourth-ventricle ependymal cells were also labeled.

135 lls lacked NET immunoreactivity, whereas CNS ependymal cells were an unexpected site of labeling.

136 In contrast, ependymal cells were labeled by BrdU administration duri

137 ved in circumventricular organs, and OCT3-ir ependymal cells were observed in the linings of all cere

138 Although, ependymal cells were once suggested to have stem cell ch

139 Tanycytes and ependymal cells were the most FGF1-responsive cell type

140 calization restored by incubation of fro/fro ependymal cells with exogenous C24:1 ceramide, which dir

141 ities, we combined patch-clamp recordings of ependymal cells with immunohistochemistry for various co

142 Here we show that ependymal cells with one or two cilia, but not multicili

143 ible roles for ASPM in sperm flagellar or in ependymal cells' cilia.

144 , osteocytes, glandular myoepithelial cells, ependymal cells, and by stromal reticular cells and foll

145 s, including neurons, glial cells, meninges, ependymal cells, and cells of cerebral vessels.

146 ected in a subset of GFAP+ astroglial cells, ependymal cells, and Dlx2+ precursors in the SVZ.

147 ain gene Mdnah5 is specifically expressed in ependymal cells, and is essential for ultrastructural an

148 e Hassall's corpuscles), and brain (neurons, ependymal cells, and macrophages) revealed the presence

149 and patterning of hypothalamic tanycytes and ependymal cells, as well as for maintenance of the cereb

150 f uniciliated, biciliated, and multiciliated ependymal cells, astrocytes, and neurons.

151 TrkB-TR is expressed in SVZ astrocytes and ependymal cells, but not in neuroblasts.

152 n ventricular progenitors destined to become ependymal cells, but not in NSCs, and is required for SV

153 sured CaV1 voltage-gated calcium channels in ependymal cells, but these channels are not specifically

154 rd ventricle, which is formed by specialized ependymal cells, called tanycytes.

155 using Nestin-Cre prevented the formation of ependymal cells, disrupting cerebrospinal fluid flow and

156 Our data indicate that, unlike cuboidal ependymal cells, ependymal cells bordering the CVOs poss

157 share the "shoreline" on the ventricles with ependymal cells, forming a unique adult ventricular zone

158 the murine brain stem and subsequently brain ependymal cells, leading to enlargement of the cerebral

159 Multiciliated epithelial cells, called ependymal cells, line the ventricles in the adult brain.

160 Spinal cord ependymal cells, previously reported to be multipotent,

161 with one or two cilia, but not multiciliated ependymal cells, proliferate and give rise to new ependy

162 for ciliogenesis in Chlamydomonas and murine ependymal cells, respectively.

163 ity and promoted aberrant growth of aqueduct ependymal cells, resulting in aqueduct stenosis and the

164 ern of expression to markers of hypothalamic ependymal cells, such as Rarres2 (retinoic acid receptor

165 topic expression of genes specific to cuboid ependymal cells, such as Rarres2.

166 antigenic and morphologic characteristics of ependymal cells, suggesting a novel form of SVZ-supporte

167 strocytes in the glial scar are generated by ependymal cells, the neural stem cells in the spinal cor

168 On the ependymal cells, these defects lead to disorganized beat

169 rectly test whether radial glia give rise to ependymal cells, we used a Cre-lox recombination strateg

170 persists at the base of the motile cilia in ependymal cells, which also exhibit a severe ciliopathy.

171 tors were localised within the tanycytes and ependymal cells, with higher expression under long (LD)

172 of adult male mice--albeit with NSCs nearer ependymal cells--and that distance from the ventricle is

173 cyte progenitor cells (OPCs), astrocytes and ependymal cells-during multiple sclerosis and other CNS

174 stricted to Purkinje neurons and a subset of ependymal cells.

175 two distinct cell populations: tanycytes and ependymal cells.

176 y confined to large ventral horn neurons and ependymal cells.

177 pical endfeet in the center of a pinwheel of ependymal cells.

178 aintenance of choroid plexus vasculature and ependymal cells.

179 reduced the injury-induced proliferation of ependymal cells.

180 rity that predicts the orientation of mature ependymal cells.

181 ial glia and then refined by motile cilia in ependymal cells.

182 ly in and induce cellular damage in infected ependymal cells.

183 d indirectly by RFX1, RFX2 and RFX3 in mouse ependymal cells.

184 hat share cellular adherens with neighboring ependymal cells.

185 eta were detected in adult CP, as well as on ependymal cells.

186 eep in zebrafish, probably via activation of ependymal cells.

187 rogenesis from postnatal SVZ progenitors and ependymal cells.

188 lia in various stages of transformation into ependymal cells.

189 icular wall transform to give rise to mature ependymal cells.

190 ytes, astrocytes, and the choroid plexus and ependymal cells.

191 ere was positive staining in the ventricular ependymal cells.

192 racic spinal cord is located on neurones and ependymal cells.

193 ian brain ventricles are lined with ciliated ependymal cells.

194 microglial activation when PV is absent from ependymal cells.

195 ngly, mWAKE is also observed in non-neuronal ependymal cells.

196 and neurogenesis as well as the formation of ependymal cells.

197 tive phenotype, similarly to injury-reactive ependymal cells.

198 is expressed in the astrocytic end feet and ependymal cells.

199 ave both redundant and specific functions in ependymal cells.

200 f Chlamydomonas flagella and motile cilia in ependymal cells.

201 mylation and glycylation in developing mouse ependymal cilia and the expression of the corresponding

202 Defects in the ependymal cilia can result in hydrocephalus, defects in

203 Ependymal cilia dysfunction can hinder the movement of C

204 ring brain development, namely impairment of ependymal cilia formation.

205 before, the effects of ethanol ingestion on ependymal cilia function have not been investigated in v

206 Here, we show that ependymal cilia generate a laminar flow of cerebrospinal

207 the beating frequency of all three types of ependymal cilia in both the third and the lateral rat br

208 thy related to defective ciliogenesis of the ependymal cilia in six individuals.

209 ies reinforce the presence of three types of ependymal cilia in the brain ventricles and demonstrate

210 Beating of ependymal cilia is required for normal CSF flow, concent

211 hanol as a risk factor for the impairment of ependymal cilia motility in the brain.

212 Ependymal cilia protrude into the central canal of the b

213 argely normal, the planar polarity of mutant ependymal cilia was disrupted, resulting in uncoordinate

214 mal denudation by apoptosis and reduction of ependymal cilia were already evident in young mice, with

215 ck model systems where the interplay between ependymal cilia, embryonic CSF flow dynamics and brain d

216 f3a and Ift88 genetic ablation also disrupts ependymal cilia, resulting in hydrocephalus by postnatal

217 Here, we report three distinct types of ependymal cilia, type-I, type-II and type-III classified

218 of the TTLL family for specific functions in ependymal cilia, we demonstrate that the glycylating enz

219 re required for stability and maintenance of ependymal cilia, whereas the polyglutamylase TTLL6 was n

220 articipates in specifying planar polarity of ependymal cilia.

221 ylating and glycylating enzymes in mammalian ependymal cilia.

222 ultrastructural and functional integrity of ependymal cilia.

223 ice also implicates Spag6 in the motility of ependymal cilia.

224 ed with hydrocephalus are colocalized to the ependymal cilia.

225 , pneumolysin caused rapid inhibition of the ependymal ciliary beat frequency and caused ependymal ce

226 zed loss of cilia, a decrease of the overall ependymal ciliary beat frequency, and damage to the epen

227 Disruption of ependymal ciliary beating, by injury or disease, results

228 Ependymal ciliary stasis by purified pneumolysin was als

229 aB-induced neuroinflammation interferes with ependymal ciliogenesis.

230 Our findings show that ependymal contribution of progeny after SCI is minimal,

231 Ependymal denudation by apoptosis and reduction of epend

232 including choroid plexus CSF hypersecretion, ependymal denudation, and damage and scarring of intrave

233 egulated PI3K-Yap signaling in normal neural-ependymal development.

234 red molecular properties of CD133(+)/GFAP(-) ependymal (E) cells in the adult mouse forebrain neuroge

235 Defects in ependymal (E) cells, which line the ventricle and genera

236 Multiciliated ependymal (E1) cells line the brain ventricles and are e

237 Multiciliated ependymal (E1) cells line the walls of the ventricles an

238 y or completely blocked by the overgrowth of ependymal epithelia.

239 sion is detectable in the choroid plexus and ependymal epithelium by immunohistochemistry or by nonin

240 ch cells of mixed neuronal and non-neuronal (ependymal) fates are formed, and a late phase, in which

241 In Mdnah5-mutant mice, lack of ependymal flow causes closure of the aqueduct and subseq

242 ugh the cerebral aqueduct, which we term as 'ependymal flow'.

243 The intraventricular delivery of, and ependymal infection by, viral vectors encoding neurotrop

244 CI is minimal, local and dependent on direct ependymal injury, indicating that ependyma are not a maj

245 ricular white matter gliosis, and axonal and ependymal injury.

246 vations, permeability studies show that this ependymal layer acts as a diffusion barrier.

247 eases (TIMPs) 1, 2, and 3 are present in the ependymal layer but not in the SVZ and RMS.

248 -chase experiment and found that a subset of ependymal layer cells (ELCs) were label-retaining after

249 Some precursor cells in the ependymal layer displayed similar transients.

250 This ependymal layer harbors well-organized tight junctions,

251 surements with origin defined by the remnant ependymal layer in the center of the granule cell layer

252 t model of meningitis to examine whether the ependymal layer is affected by S. pneumoniae.

253 bventricular zone of lateral ventricles, and ependymal layer of 3rd ventricle of adult brains.

254 adult brain of both rodents and humans, the ependymal layer of the lateral ventricle contains cells

255 We hypothesized that cells within the ependymal layer of the original spinal cord include popu

256 ur results demonstrate that cells within the ependymal layer of the original, regenerating and fully

257 d interneurons, but do not contribute to the ependymal layer of the postnatal spinal cord.

258 -positive terminals were seen contacting the ependymal layer of the third and fourth ventricles.

259 We show that primarily Th1 cells cross the ependymal layer of the ventricle and migrate within the

260 ted spinal cord with a simple morphology: an ependymal layer surrounded by nerve tracts.

261 ls were observed adjacent to the ventricular ependymal layer.

262 compromised ependymal cells of the adhering ependymal layers upregulate PV and display phenotype shi

263 ains a hypocellular gap layer separating the ependymal lining from a periventricular ribbon of astroc

264 PDGF-C-deficient mice displayed a distorted ependymal lining of the lateral ventricles, and we found

265 ft in cellular tropism from 2,3-linked SA(+) ependymal lining to 2,8-linked PSA(+) migrating progenit

266 in lytic infection of the choroid plexus and ependymal lining, marked meningitis, and 100% mortality

267 of astrocytes interposed within the adjacent ependymal lining.

268 ular wall and reduction of both tanycyte and ependymal markers.

269 be consistent with a cerebrospinal fluid or ependymal mediated pathogenesis.

270 We conclude that beating of ependymal motile cilia is not tightly regulated by volta

271 r and intercellular rotational alignments of ependymal motile cilia were disrupted.

272 ular rotational alignment and positioning of ependymal motile cilia.

273 tein (GFAP), excluding the possibility of an ependymal nature.

274 lial growth factor (VEGF) activated CD133(+) ependymal neural stem cells (NSCs), lining not only the

275 We thus propose that ependymal Noggin production creates a neurogenic environ

276 This study revealed the existence of dormant ependymal NSCs throughout the ventricular surface of the

277 Targeting a pathway regulating ependymal organization/assembly and showing its requirem

278 Ependymal overexpression of brain-derived neurotrophic f

279 These results suggest that ependymal planar cell polarity is a multistep process in

280 little is known about the mechanisms guiding ependymal planar polarity and whether this organization

281 aporin-4 pool but retain the non-endfoot and ependymal pools.

282 tion of progenitors and apical attachment of ependymal precursor cells.

283 ealed a remarkable network of astrocytic and ependymal processes.

284 al spinal fluid, TNF-alpha expression in the ependymal region, and the influx of neutrophils of encep

285 n we localized aromatase-expressing cells to ependymal regions bordering the ventricles from the fore

286 idge-forming astrocytes are not derived from ependymal stem cells within the spinal cord, suggesting

287 identified in the lateral ventricles a rare ependymal subpopulation (E2) with only two cilia and uni

288 s, IHC staining was seen in association with ependymal surfaces and periventricular regions of formal

289 dent at cerebral cortex pial and ventricular ependymal surfaces in ASD.

290 ercentage of BrdU labeling was higher in the ependymal than in nonependymal regions.

291 Ependymal tumors across age groups are currently classif

292 al ciliary beat frequency, and damage to the ependymal ultrastructure during meningitis.

293 shRNA into the third ventricle, transducing ependymal wall cells and tanycytes.

294 tified roles for Numb/Numblike in regulating ependymal wall integrity and SVZ neuroblast survival.

295 we identified fluorescent tissue in the sub-ependymal zone (SEZ) of patients with glioblastoma.

296 o which newly generated neurons from the sub-ependymal zone migrate and integrate, and present a comp

297 e leverage the spatial separation of the sub-ependymal zone NSC niche and the olfactory bulb, the reg

298 rocytes generated after SCI are derived from ependymal zone stem cells (EZCs).

299 is required for the proper formation of the ependymal zone, the epithelial cell lining of the centra

300 ever, the new neurons were restricted to the ependymal zone, were never labeled by antineurofilament