ライフサイエンスコーパス: epicardium

1 thm at 5 layers (endocardium, 25%, 50%, 75%, epicardium).

2 n-myocardial layers (endocardium-endothelium-epicardium).

3 lectrograms and activation delay at the RVOT epicardium.

4 oth muscle progenitor cells in the embryonic epicardium.

5 thetic innervation are similar to that of LV epicardium.

6 the correct formation of a mature epithelial epicardium.

7 1), but no such correlation was found in the epicardium.

8 rction decreases from the endocardium to the epicardium.

9 l incision onto/in parallel with ventricular epicardium.

10 tion and failure to form a mature epithelial epicardium.

11 (CS) to stimulate the left ventricular (LV) epicardium.

12 -Ca(2+) exchanger, at the base of the female epicardium.

13 lated from the base and apex of adult female epicardium.

14 iated poor and variable recombination in the epicardium.

15 1 by disrupting Pdgfralpha expression in the epicardium.

16 en pacing from the endocardium than from the epicardium.

17 pex, and coronary sinus and left ventricular epicardium.

18 ith a tissue-specific deletion of Nf1 in the epicardium.

19 rescued the cuboidal phenotype of the mutant epicardium.

20 ar heart tube before establishment of a (pro)epicardium.

21 clusively expressed in the fully delaminated epicardium.

22 ersus 50 W.10 s) were performed at the swine epicardium.

23 were also markedly downregulated in Wt1(KO) epicardium.

24 ization over the anterior aspect of the RVOT epicardium.

25 clusively in the anterior aspect of the RVOT epicardium.

26 detected no change in E-cadherin in Wt1(KO) epicardium.

27 d1 lineage marks the proepicardial organ and epicardium.

28 nal activities in the AVE and the developing epicardium.

29 ells unexpectedly richly populated the adult epicardium.

30 s exhibit downregulation of Igf2 mRNA in the epicardium.

31 um, whereas mast cells are found also in the epicardium.

32 ing from the ischemic border on the anterior epicardium.

33 share some similarities with the vertebrate epicardium.

34 achycardia in NICM often originates from the epicardium.

35 was consistent with a primary defect in the epicardium.

36 he cuboidal cell shape observed in the Wt1KO epicardium.

37 quent translocation to the heart to form the epicardium.

38 cardial APD80 more significantly than in the epicardium.

39 and envelop the maturing heart, forming the epicardium.

40 ore MV leaflet coaptation and secured at the epicardium.

41 re correctly mapped to either endocardium or epicardium.

42 vations at the base and mid left ventricular epicardium.

43 covery interval patterns were similar to the epicardium.

44 ely 2 times higher than in the lateral wall (epicardium, 0.14+/-0.07 versus 0.05+/-0.03; midwall, 0.2

45 eater than in the lateral equatorial region (epicardium, 0.16+/-0.15 versus 0.03+/-0.06; endocardium,

46 appeared equally frequent at endocardium and epicardium (11% versus 13%; P=0.18).

47 nd right ventricular endocardium than in the epicardium (15 [8-25] and 13 [7-22] g versus 8 [4-13] g,

48 versus 49 +/- 2 cm/s in NF, P=0.008) to the epicardium (28 +/- 3 cm/s versus 40 +/- 2 cm/s in NF, P=

49 endocardium (4.1% vs. 1.3%; p = 0.0003) and epicardium (4.3% vs. 2.1%, p = 0.035).

50 were prone to complex circuits involving the epicardium (7/11; 63.6%).

51 s rhythm (endocardium, 509+/-291 points/map; epicardium, 716+/-323 points/map).

52 V for endocardium) was more extensive on the epicardium (95+/-47 versus 38+/-32 cm(2); P<0.001) and w

53 Total scar area was larger on the epicardium (97+/-78 cm(2)) than the endocardium (57+/-44

54 Amongst these tissues is the epicardium, a cell structure that develops from the prec

55 The epicardium, a mesothelial cell layer enveloping the myoc

56 st adult cardiac fibroblasts derive from the epicardium, a minority arises from endothelial cells, an

57 that this adipose tissue originates from the epicardium, a multipotent epithelium that until now is o

58 diovascular progenitor cells arises from the epicardium, a single layer of mesothelium lining the hea

59 Here we find that genetic depletion of the epicardium after myocardial loss inhibits cardiomyocyte

60 nscription factor Wt1 and located within the epicardium-an epithelial sheet overlying the heart.

61 t, the low bipolar voltage area (<1.0 mV for epicardium and <1.5 mV for endocardium) was more extensi

62 ng (1) superficially within the regenerating epicardium and (2) intra-ventricularly toward the activa

63 sident fibroblasts originating from both the epicardium and a previously unrecognized source, the end

64 S is commonly located in the right ventricle epicardium and ajmaline exposes its extent and distribut

65 RNA and Wt1 protein in the proepicardium and epicardium and also in endothelial cells throughout card

66 and nrp2b) were upregulated by the activated epicardium and an nrp1a-knockout mutant showed a signifi

67 t1/betacatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac re

68 using vacuum pressure for prehension of the epicardium and drive wires for actuation.

69 Moreover, paracrine signaling from the epicardium and endocardium is critical for proper develo

70 findings indicate that the injury-activated epicardium and endocardium support cardiomyocyte repleni

71 earliest activation was simultaneous at the epicardium and endocardium.

72 ere isolated from five muscle layers between epicardium and endocardium.

73 (P<0.001 versus acute AF) and similar in the epicardium and endocardium.

74 vation of different cell types including the epicardium and endocardium.

75 Tcf21) is expressed in subpopulations of the epicardium and EPDCs in chicken and mouse embryonic hear

76 xpressed in cells of the proepicardium (PE), epicardium and EPDCs in mouse and chick embryos.

77 or Bmpr1a) was conditionally deleted in the epicardium and EPDCs using the mWt1/IRES/GFP-Cre (Wt1(Cr

78 ly, these findings suggest that HPSC-derived epicardium and EPI-SMCs could serve as important tools f

79 eage tracing approaches to track and isolate epicardium and epicardium derivatives in hearts lacking

80 e a chemically defined method for generating epicardium and epicardium-derived smooth muscle cells (E

81 mesenchymal protrusion, pulmonary arteries, epicardium and fourth pharyngeal arch artery.

82 he base of female than male left ventricular epicardium and greater at the base than at the apex in b

83 rdial cells employ to establish a functional epicardium and how they communicate with other cardiovas

84 trode basket catheter were placed around the epicardium and in the left ventricle (LV), respectively.

85 wall-thickness measurements attached to the epicardium and invasive pressure monitoring established,

86 The epicardium and its derivatives provide trophic and struc

87 -dioxin (TCDD) prevents the formation of the epicardium and leads to severe heart malformations in de

88 perimental MI, these macrophages invaded the epicardium and lost Gata6 expression but continued to pe

89 uption of cell-cell interactions between the epicardium and myocardium resulting in a thinned myocard

90 its stiffer isoform were increased in the LV epicardium and paralleled the changes in fibronectin and

91 ates Wnt1 that is initially expressed in the epicardium and subsequently by cardiac fibroblasts in th

92 pha) expression at specific sites within the epicardium and support a link between hypoxia inducible

93 A activity is completely lost in Raldh2(-/-) epicardium and the adjacent myocardium, RA activity is n

94 ithelial-mesenchymal transition (EMT) in the epicardium and the reverse process (MET) in kidney mesen

95 d while the movement of EPDCs within the sub-epicardium and their differentiation into smooth muscle

96 eart, CXCL12 is expressed principally by the epicardium, and its receptor CXCR4 is expressed by coron

97 ium, then repeated over surgically disrupted epicardium, and then finally with the patch applied pass

98 e onto the outer cardiac surface to form the epicardium, and then make a substantial contribution to

99 Secreted factors from the epicardium are believed to be important in directing hea

100 The coronary vessels and epicardium arise from an extracardiac rudiment called th

101 -transition (EMT) and arrested maturation of epicardium around E11.5.

102 nvestigate the lineage relationships between epicardium, arterial mesothelial cells (AMCs), and the c

103 ISO decreased APD significantly more in the epicardium as compared to the endocardium, with subseque

104 Microelectrode recordings from the RV-epicardium at the onset of focal activity showed early a

105 Although the epicardium becomes dormant after birth, cardiac injury r

106 The patches were applied on 6 canines to epicardium before and after surgical disruption.

107 We reveal that the epicardium begins to envelop the myocardial surface at C

108 nated electrical activity was observed in RV epicardium, but not in endocardium, as a consequence of

109 ctivated specifically in the endocardium and epicardium, but not the myocardium.

110 ation of a developmental gene program in the epicardium, but the transcriptional basis of epicardial

111 vivo procedures for genetic ablation of the epicardium, cell proliferation assays, tissue grafts and

112 In the developing heart, the epicardium constitutes the primary source of progenitor

113 Here we show that the adult epicardium contains a population of CD45+ haematopoietic

114 transition; however, it is not clear how the epicardium contributes to disease progression or repair

115 for the first time definitive evidence that epicardium contributes to formation of the mammalian ann

116 The epicardium contributes to multiple cardiac lineages and

117 itish circular scars with indentation of the epicardium could be identified.

118 proaches to track and isolate epicardium and epicardium derivatives in hearts lacking Wt1 (Wt1(KO)).

119 oxP technology to assess the contribution of epicardium derived cells (EPDCs) to the annulus fibrosis

120 Single cell RNA sequencing of epicardium derived from human pluripotent stem cells (hP

121 Permanent genetic tracing of epicardium-derived cell (EPDC) and bone marrow-derived b

122 Epicardium-derived cells (EPDCs) contribute cardiovascul

123 Epicardium-derived cells (EPDCs) contribute to formation

124 Epicardium-derived cells (EPDCs) invade the myocardium a

125 actor (hSCF) enhances epicardial activation, epicardium-derived cells (EPDCs) production, and myocard

126 ll proliferation and stimulated formation of epicardium-derived cells (EPDCs), which remained in a th

127 regulatory sequences provided evidence that epicardium-derived cells also adopt a myocardial fate in

128 also stimulated the proliferation of WT1(+) epicardium-derived cells but only in the hypoxic area of

129 pogenic differentiation of adult mesenchymal epicardium-derived cells by modulating the balance betwe

130 ntributor to cardiovascular development, and epicardium-derived cells have the potential to different

131 Some epicardium-derived cells that undergo epithelial-to-mese

132 Moreover, epicardium-derived CFs display stromal properties with r

133 Epicardium-derived progenitor cell (EPDC) formation requ

134 marize the molecular mechanisms that control epicardium-derived progenitor cell migration, and the fu

135 t novel therapeutic strategies to manipulate epicardium-derived progenitor cells for cardiac repair.

136 shown to restore vascular potential to adult epicardium-derived progenitor cells with injury.

137 ducible Cre driver revealed unique roles for epicardium-derived Shha in myocardial proliferation duri

138 defined method for generating epicardium and epicardium-derived smooth muscle cells (EPI-SMCs) and CF

139 Targeting epicardium-derived stromal cells (EpiSC) by specific lig

140 kit expression in the adult heart identifies epicardium-derived, noncardiomyogenic precursors with a

141 primary tissue samples to characterise human epicardium development.

142 and the expression of Cxcl10 and Ccl5 during epicardium development.

143 t cause cardiac malformations, or defects in epicardium development.

144 es, which could affect cell migration during epicardium development.

145 g basic cycle distance, in the Scn5a(+/-) RV epicardium, directly predictive of its arrhythmic phenot

146 HPSC-derived epicardium displayed enhanced expression of epithelial-

147 ation of Mrtfa and Mrtfb specifically in the epicardium disrupts cell migration and leads to sub-epic

148 ed spatially between the endocardium and the epicardium (dominant frequency, 0.79 +/- 0.06 and regula

149 absence of VEGFC, which is expressed in the epicardium, dramatically inhibited dorsal and lateral co

150 By studying the heart epicardium during embryogenesis, we show that Lb1-null e

151 vo, Igf2 is expressed in the embryonic mouse epicardium during midgestation heart development.

152 be ectopically induced in mouse ventricular epicardium, either in embryonic or adult stages, by expr

153 The epicardium encapsulates the heart and functions as a sou

154 ctivities in the endocardium (Endo-LAVA) and epicardium (Epi-LAVA), followed by epicardial ablation i

155 transition (EMT) as shown by analyses of the epicardium, epicardial-derived cells, and fate mapping.

156 or comprehensive whole-field, endocardium-to-epicardium evaluation for microvascular density, fibrosi

157 ecifically, the ventricular, but not atrial, epicardium exhibited areas of expanded epithelium, prefe

158 Wt1(KO) epicardium expressed decreased levels of canonical Wnt d

159 Wt1(KO) epicardium expressed reduced Lef1 and Ctnnb1 (beta-caten

160 In the developing embryo, the epicardium expresses the transcriptional regulator Wilm'

161 Wt1(KO) epicardium failed to undergo EMT.

162 nous pole of the heart and gives rise to the epicardium, fibroblasts, and smooth muscle cells.

163 lves the activation and proliferation of the epicardium, followed by an epithelial-to-mesenchymal tra

164 were found non-uniformly distributed on the epicardium following pericardial administration, display

165 sing the regenerative potential of the fetal epicardium for cardiac repair.

166 NEPPS and fiducial markers were glued to the epicardium for motion tracking.

167 The importance of the epicardium for myocardial and valvuloseptal development

168 FGF signaling promotes epicardium formation in vivo, and biochemical studies de

169 However, the mechanism of epicardium formation is unclear.

170 Epicardial-specific Cdc42 deletion disrupted epicardium formation, and Cdc42 null PECs proliferated l

171 ts into its underlying cell biology, notably epicardium formation, lineage heterogeneity, and functio

172 F receptors to the cell membrane to regulate epicardium formation.

173 The epicardium harbors a population of progenitor cells that

174 In recent years, the epicardium has been identified as an important contribut

175 The epicardium has emerged as a multipotent cardiovascular p

176 events leading to the formation of the human epicardium has essentially been extrapolated from model

177 Thus, the ventricular epicardium has pronounced regenerative capacity, regulat

178 However, whether the epicardium has similar roles postnatally in the normal a

179 , and the interactions of the myocardium and epicardium have opened the door to new approaches for he

180 The murine developing epicardium heterogeneously expresses the transcription f

181 icular septum in 2 patients (22%) and at the epicardium in 1 patient (11%).

182 surrogate for APD, were measured from the LV epicardium in 13 patients at day 0, 6 weeks, and 6 month

183 related VT, target sites were located at the epicardium in 5 patients (63%) and in the endocardial in

184 F characteristics using irrigated RFA on the epicardium in an ovine model.

185 ardia circuits contained entirely within the epicardium in ARVD and explains observations on the need

186 These findings reveal a new role for the epicardium in establishing an extracellular environment

187 e anterior aspects of right ventricular (RV) epicardium in experimental models of Brugada syndrome (B

188 Recent studies have implicated the epicardium in multiple aspects of cardiac repair: as a s

189 The role of the epicardium in myocardial morphogenesis and establishment

190 have shown a role for Hippo signaling in the epicardium in suppressing the post-infarct inflammatory

191 fect in the maturation process of the mutant epicardium, including sustained upregulation of Bmp4 exp

192 The epicardium initially forms from a dynamic precursor stru

193 y observed in the cell junction of the skin, epicardium, intestine, and cornea of both developmental

194 The epicardium is a cellular source with the potential to re

195 The embryonic epicardium is a crucial cell source of the cardiac fibro

196 The epicardium is a major contributor of the cells that are

197 The epicardium is a mesothelial cell layer essential for ver

198 The adult epicardium is a potential source of cardiac progenitors

199 The epicardium is a sheet of epithelial cells covering the h

200 oduced conflicting results about whether the epicardium is a source of cardiac muscle cells during he

201 Following cardiac injury, the epicardium is activated organ-wide in a Wnt-dependent ma

202 tissue layer enveloping the heart called the epicardium is activated to proliferate and accumulate at

203 The epicardium is also a source of paracrine cues that are e

204 The embryonic epicardium is an important source of cardiovascular prec

205 The epicardium is essential during cardiac development, home

206 The epicardium is essential for mammalian heart development.

207 ntrary to prevailing dogma, the formed human epicardium is not a simple squamous epithelium and we re

208 wever, the biology and dynamism of the adult epicardium is poorly understood.

209 Epicardium is reactivated during the formation of the at

210 Although it is recognized that epicardium is required for muscle regeneration and itsel

211 athway in the developing heart, and that the epicardium is required for this response.

212 The epicardium is the last layer of the vertebrate heart to

213 The epicardium is the primary source of coronary vascular sm

214 pment, including in the heart, but a role in epicardium is unknown.

215 t1, one of the main markers of the embryonic epicardium, is essential for epicardial development and

216 wever, the potential activity of Tbx5 in the epicardium itself, and the role of Tbx5 in mammalian cor

217 diffusion between the pericardial fluid and epicardium [L/h].

218 .005 cm(-2) s(-)(1) (P<0.001) in left atrial epicardium (LA(epi)), and prolonged AF cycle length (AFC

219 sm for regeneration is the activation of the epicardium, leading to the establishment of a supporting

220 ption of Numb and Numblike expression in the epicardium led to randomized mitotic spindle orientation

221 gesting that the earliest progenitors of the epicardium lie in the LPM.

222 An epithelial sheet, the epicardium, lines the surface of the heart.

223 The mesothelial epicardium lost epithelial gene expression and became mo

224 The epicardium makes essential cellular and paracrine contri

225 most of the scar tissue was confined to the epicardium; mapping identified and eliminated an epicard

226 ducing epicardial cells, suggesting that the epicardium may be involved in localizing inflammation to

227 ough certain foci including aortic cusps and epicardium may be technically challenging.

228 sion and activation of PPARgamma at times of epicardium-mesenchymal transformation.

229 rt model consisted of four compartments: the epicardium, midmyocardium, endocardium, and pericardial

230 Our findings indicate that epicardium modulates the cardiac injury response by cond

231 hearts, suggesting that RA signaling in the epicardium/myocardium is not required for myocardial com

232 ain and two-domain computer models of normal epicardium (NZ) to understand how extracellular space mo

233 t coronary cusp, aortomitral continuity, and epicardium, occasionally the basal left ventricular summ

234 rams were acquired at 240 sites covering the epicardium of 41 patients at 6 cycle lengths (600-350 ms

235 ndle branches (LBB) or left ventricular (LV) epicardium of atrioventricular-blocked dogs.

236 was reduced in the anterior left ventricular epicardium of DBH-Sap hearts compared to control.

237 s) were created on the left ventricular (LV) epicardium of M9PROM mice (n=62) and terminally studied

238 stic membranes shaped precisely to match the epicardium of the heart via the use of 3D printing, as a

239 vity on bipolar electrograms recorded in the epicardium of the RV outflow tract in patients with BrS.

240 substrate site is the RVOT, either over the epicardium or endocardium; abnormal electrograms would b

241 ineages occurs early in the formation of the epicardium or later after the cells have entered the myo

242 l myocardium, the intramural myocardium, the epicardium, or the His Purkinje system.

243 ardium (P<0.001) and from 90% to 100% on the epicardium (P=0.02).

244 ntricle pairs (P=0.021) and left ventricular epicardium (P=0.08).

245 ocardium (39+/-18 g versus 21+/-14 g for the epicardium; P<0.001) mainly because of axial force.

246 % at 50%, 13.1+/-10.4 at 75%, 12.1+/-9.3% at epicardium; P<0.01).

247 of pro-epicardial cells (PECs) from the pro-epicardium (PE) and their subsequent translocation to th

248 The epicardium plays a crucial role in embryonic heart devel

249 ynamic Notch injury response activates adult epicardium, producing a multipotent cell population that

250 Loss of sox9b prevented the formation of epicardium progenitors comprising the proepicardium on t

251 l-defined repolarization edge traversing the epicardium, PVEM can reliably provoke VF if, and only if

252 Disruption of C/EBP signaling in the adult epicardium reduced injury-induced neutrophil infiltratio

253 his cell heterogeneity is conserved in human epicardium, regulated by BNC1 and associated with cell f

254 development, including actions in the fetal epicardium required for myocardial growth.

255 points in the left ventricle endocardium and epicardium, respectively.

256 Hearts with epicardium-restricted Ctnnb1 loss of function resembled

257 decreased progressively from endocardium to epicardium (scar area/left ventricular area: 34.0+/-17.4

258 The epicardium serves as a source of growth factors that reg

259 ntrast, allograft lymphatics in and near the epicardium showed no significant density decline but inc

260 e heart, this cell lineage gives rise to the epicardium, smooth muscle cells, and potentially fibrobl

261 cription factor gene tcf21 activated robust, epicardium-specific expression throughout development an

262 a conditional shha mutant generated using an epicardium-specific inducible Cre driver revealed unique

263 layed enhanced expression of epithelial- and epicardium-specific markers, exhibited morphological fea

264 cine study was performed on left ventricular epicardium submerged under 10 mm of blood, using devices

265 During SR, EMD is longer at the epicardium than at the endocardium, and is greater near

266 ractionation was significantly higher in the epicardium than endocardium (61.2% versus 51.6%, P<0.000

267 Maximum theta' was lower in Scn5a(+/-) RV epicardium than endocardium.

268 Here, we examined if the epicardium that contains multipotent cells is involved i

269 ta provide insight into the developing human epicardium that may contribute to our understanding of c

270 ion of a regeneration-specific matrix in the epicardium that precedes the accumulation and migration

271 single layer of mesothelial cells called the epicardium that provides important cellular contribution

272 originates from migratory mesothelial cells (epicardium) that give rise to coronary vascular smooth m

273 e find in zebrafish that regeneration of the epicardium, the mesothelial covering of the heart, is me

274 The epicardium, the outermost tissue layer that envelops the

275 pends on a complex communication between the epicardium, the subepicardial mesenchyme, and the myocar

276 The cells of the epicardium then delaminate and incorporate into the hear

277 ctroanatomic mapping was performed on normal epicardium, then repeated over surgically disrupted epic

278 tion as a consequence of cardiac disease and epicardium to adipocyte differentiation should be taken

279 heart field cardiac progenitor cells at the epicardium to adipocytes due to enhanced expression of a

280 olic Ca(i)-voltage coupling gain and enabled epicardium to also generate TAs.

281 of human embryonic stem cell (hESC)-derived epicardium to augment the structure and function of engi

282 ion, and the functional contributions of the epicardium to heart formation and cardiomyopathy.

283 these epicardial-derived cells (EPDCs), the epicardium undergoes the process of epithelial to mesenc

284 that muscular connections between endo- and epicardium underlie EBW and that a slight degree of endo

285 eluting transvenous lead was placed from the epicardium via purse-string incision or atriotomy and af

286 on mapping (Rhythmia) of the endocardium and epicardium via the coronary sinus.

287 The epicardium vigorously regenerates after its ablation, th

288 high-density electroanatomic mapping of the epicardium was also performed, and border zone and dense

289 SkM1 expression in injected epicardium was confirmed immunohistochemically.

290 understand the autocrine role of HIFs in the epicardium, we transduced adenovirus mediated expression

291 r of retinoic acid signaling confined to the epicardium, were also markedly downregulated in Wt1(KO)

292 pha (AdcaHIF1alpha) into the embryonic avian epicardium where the vascular precursors reside.

293 ential duration (APD) in the endocardium and epicardium which may be pro-arrhythmic.

294 rm a contribution of HCs to the intact adult epicardium, which is elevated during the first 24 weeks

295 contribution of CD45+ HCs to the developing epicardium, which is not derived from the proepicardial

296 eas of AES were found in the right ventricle epicardium, which were wider in group 1 (P=0.007).

297 D patients had major activation delay to the epicardium with laminar central scar activation from the

298 Imaging was used to identify the epicardium with saline infusion into the pericardial spa

299 Twenty-seven VTs were targeted on the epicardium with the use of activation, entrainment, or p

300 te adhesion of the electrodes or mesh to the epicardium without damage to underlying vasculature.