ライフサイエンスコーパス: epidermal differentiation

1 ulate developmental processes, such as human epidermal differentiation.

2 ntaining 11.6 % of open chromatin regions in epidermal differentiation.

3 onnected hub that is strongly induced during epidermal differentiation.

4 esting the emergence of organizing themes in epidermal differentiation.

5 on receptor (AHR), resulting in induction of epidermal differentiation.

6 e population, are characterized by disrupted epidermal differentiation.

7 suppressed malignant phenotypes and induced epidermal differentiation.

8 s into the potent role of miR-203 during the epidermal differentiation.

9 lso be targets of KLF4, a known activator of epidermal differentiation.

10 , a transcription factor that activates late epidermal differentiation.

11 exhibit ectopic proliferation and defective epidermal differentiation.

12 Myc and an essential mediator of Myc-induced epidermal differentiation.

13 siological ER stress is essential for normal epidermal differentiation.

14 defined a requirement for ZNF750 in terminal epidermal differentiation.

15 he hair follicle and epidermis and decreased epidermal differentiation.

16 are recruited to the cell cortex by DP upon epidermal differentiation.

17 ytokine axes (T(H)2/T(H)22/T(H)17/T(H)1) and epidermal differentiation.

18 o the structural genes that are required for epidermal differentiation.

19 the epidermis, and Smad2/3 are required for epidermal differentiation.

20 unctions as a molecular switch that controls epidermal differentiation.

21 tic derepression by JMJD3 controls mammalian epidermal differentiation.

22 nteract some of the effects of cytokinins on epidermal differentiation.

23 e regional influence of GA and cytokinins on epidermal differentiation.

24 to cysts of cells undergoing interfollicular epidermal differentiation.

25 iate a zymogen cascade that is essential for epidermal differentiation.

26 te that class II PI3Ks are not essential for epidermal differentiation.

27 s, suggesting a potential role for C2beta in epidermal differentiation.

28 andidate to be involved in the regulation of epidermal differentiation.

29 cial tissue-specific regulator of vertebrate epidermal differentiation.

30 coordinately increase CAMP production during epidermal differentiation.

31 ession of target genes to specific stages of epidermal differentiation.

32 ethylene is known to act at later stages of epidermal differentiation.

33 gesting an important role for this enzyme in epidermal differentiation.

34 ng involucrin, one of the genes required for epidermal differentiation.

35 ap-junctional intercellular communication in epidermal differentiation.

36 type mice, but gene disruption did not alter epidermal differentiation.

37 odermal derivatives and inhibited neural and epidermal differentiation.

38 iated by both Cx31 and Cx30.3 is crucial for epidermal differentiation.

39 sing pathway and a key regulator of terminal epidermal differentiation.

40 l programs that are regulated by IRF6 during epidermal differentiation.

41 n potentially plays a role in the process of epidermal differentiation.

42 llicle morphogenesis and cycling, as well as epidermal differentiation.

43 dermis, indicating that oxysterols stimulate epidermal differentiation.

44 perinatal lethality associated with abnormal epidermal differentiation.

45 yer of the skin, which is the end-product of epidermal differentiation.

46 ave defects in the brain, immune system, and epidermal differentiation.

47 y with skin abnormalities including aberrant epidermal differentiation.

48 maintenance in epidermis and contributes to epidermal differentiation.

49 l hyperproliferation and a possible delay in epidermal differentiation.

50 ein1 (Dsg1) and Desmoplakin (Dp), to promote epidermal differentiation.

51 ) and IV (FLG/FLG) HEEs showed impaired late epidermal differentiation.

52 and were enriched for genes associated with epidermal differentiation.

53 er capture Hi-C (CHi-C) was performed during epidermal differentiation.

54 ted ETS-family transcription factor, EHF, in epidermal differentiation.

55 phoproteomic changes occur and contribute to epidermal differentiation.

56 nteracting serine-threonine kinase 4) during epidermal differentiation.

57 main by RIPK4 is essential for their role in epidermal differentiation.

58 g into filaggrin monomers and ultimately the epidermal differentiation.

59 nd previously unrecognized genes controlling epidermal differentiation.

60 to spatially regulate Notch signaling during epidermal differentiation.

61 were maintained at centrosomes upon initial epidermal differentiation.

62 y of transglutaminases (TGs) during terminal epidermal differentiation.

63 ocalization, Notch signaling, and subsequent epidermal differentiation.

64 hondrial proteins is therefore essential for epidermal differentiation.

65 ed Fra-2/AP-1 as a key regulator of terminal epidermal differentiation.

66 A lncRNA-TF network is thus essential for epidermal differentiation.

67 ription factor, egr-5, that is essential for epidermal differentiation.

68 NCR-CALML5-SFN network is thus essential for epidermal differentiation.

69 of differentially expressed genes linked to epidermal differentiation.

70 eased reactive oxygen species (ROS) to drive epidermal differentiation.

71 lts suggest that Hoxb13 functions to promote epidermal differentiation, a critical process for skin r

72 ategy for reversing UV-induced impairment of epidermal differentiation after acute sun exposure.

73 nulosum, we studied the regulation of murine epidermal differentiation after loss of calcium accompan

74 otein is a key regulator of keratinocyte and epidermal differentiation and a critical suppressor of s

75 "core" signature characterized by disturbed epidermal differentiation and activation of IL-31/IL-1 s

76 hemical alterations associated with abnormal epidermal differentiation and barrier formation in HI ep

77 ible factors are central to the processes of epidermal differentiation and barrier formation, in part

78 BCA12 will lead to a better understanding of epidermal differentiation and barrier formation.

79 ed serine protease, plays essential roles in epidermal differentiation and barrier function, largely

80 isk human papillomaviruses (HPVs) deregulate epidermal differentiation and cause anogenital and head

81 c-MYC, a transcription factor that controls epidermal differentiation and cell proliferation and who

82 explain the mechanism of retinoid action in epidermal differentiation and chemoprevention.

83 3/Get1); Grhl3-deleted mice exhibit impaired epidermal differentiation and decreased expression of mu

84 ivators of liver X receptors (LXR) stimulate epidermal differentiation and development, but inhibit k

85 , beta-catenin signaling actively suppresses epidermal differentiation and directs pigmentation and n

86 cient skin that reflect an altered course of epidermal differentiation and enhanced inflammatory resp

87 CAMP production is increased during epidermal differentiation and enriched in the stratum co

88 ical skin conditions, including disorders of epidermal differentiation and epidermal tumors.

89 g SMARCA complex components, SOX6 suppresses epidermal differentiation and epigenetically silences cr

90 thick, it expresses the classical markers of epidermal differentiation and establishes a functional b

91 e expressed in NHEK-HPV cells and changes in epidermal differentiation and gene expression examined.

92 This enables vitamin D to regulate epidermal differentiation and hair follicle cycling and,

93 osing effects in shared pathways influencing epidermal differentiation and immune response.

94 These TGM1 mutations trigger the abnormal epidermal differentiation and impaired cutaneous barrier

95 he role of aberrant connexin hemichannels in epidermal differentiation and inherited connexin disorde

96 imerizes with retinoid X receptor, stimulate epidermal differentiation and inhibit proliferation.

97 ing protein kinase 4 (RIPK4) is required for epidermal differentiation and is mutated in Bartsocas-Pa

98 hat the protein plays an independent role in epidermal differentiation and is required for epidermal

99 n activation cascade that regulates terminal epidermal differentiation and is required for prostasin

100 ubset of genes encoding proteins involved in epidermal differentiation and lipid metabolism.

101 s for HA-CD44 interaction in regulating both epidermal differentiation and lipid synthesis/secretion,

102 TIVE KERNEL1 (DEK1) is a master regulator of epidermal differentiation and maintenance, acting upstre

103 They have been implicated in epidermal differentiation and may therefore play an impo

104 ium but, in Drosophila, function in terminal epidermal differentiation and patterning of adult legs.

105 The impairment in epidermal differentiation and permeability barrier in (E

106 Delta NLef1 does not suppress epidermal differentiation and promote ORS/bulge differen

107 deficiency in psoriatic skin interferes with epidermal differentiation and promotes a sustained and l

108 ciency accelerated wound closure, increasing epidermal differentiation and reepithelialization, despi

109 asal epidermal keratinocytes, exhibit normal epidermal differentiation and skeletal morphology.

110 ptor (AHR) by xenobiotics is known to affect epidermal differentiation and skin barrier formation.

111 The role of hypoxia in epidermal differentiation and skin barrier function is i

112 aPKC-lambda has recently been implicated in epidermal differentiation and stem cell fate; however, w

113 Epidermal differentiation and stratification, crucial fo

114 ures or in 3D skin equivalents have impaired epidermal differentiation and stratification.

115 ether PPAR-alpha plays a physiologic role in epidermal differentiation and stratum corneum formation

116 Furthermore, we have reported that both epidermal differentiation and stratum corneum formation

117 -p53 interplay as a major regulatory axis in epidermal differentiation and suggest that DLX3 is a mod

118 expression coincident with normalization of epidermal differentiation and suppression of inflammator

119 rinciple tight junction components, and that epidermal differentiation and thickness were increased.

120 Ichthyoses lacked the epidermal differentiation and tight junction alterations

121 m by which IkappaB kinase 1 (IKK1) regulates epidermal differentiation and tumor suppression in the s

122 Notch signalling regulates epidermal differentiation and tumour formation via non-c

123 , and ulceration, without obvious effects on epidermal differentiation and wound healing.

124 n profile characterized by genes involved in epidermal differentiation and wound repair, which were d

125 acterized by epidermal hyperplasia, impaired epidermal differentiation, and accumulation of dermal CD

126 lacode and hair shaft fate at the expense of epidermal differentiation, and activates signals directi

127 r is expressed in defined cell layers during epidermal differentiation, and because AP1 factors regul

128 in lipid metabolism, antimicrobial defenses, epidermal differentiation, and control of cutaneous vasc

129 eased epidermal cell proliferation, impaired epidermal differentiation, and decreased the density and

130 sicles and show hyperproliferation, abnormal epidermal differentiation, and derangement of intercellu

131 normal skin barrier function, alterations in epidermal differentiation, and developmental anomalies o

132 GCN2 thwarted translational control, normal epidermal differentiation, and differentiation gene expr

133 f phosphoproteomic changes that occur during epidermal differentiation, and identifies RIPK-PKP1 sign

134 vealed that Glis1DeltaC promoted PMA-induced epidermal differentiation, as indicated by increased exp

135 olatum robustly modulates antimicrobials and epidermal differentiation barrier measures.

136 3 ablation in epidermis is linked to altered epidermal differentiation, barrier development, and IL-1

137 mitochondrial uncoupling drove keratinocyte/epidermal differentiation both in vitro and in vivo.

138 iation-induced ncRNA (TINCR), controls human epidermal differentiation by a post-transcriptional mech

139 trolling the open chromatin landscape during epidermal differentiation by cooperating with the master

140 Thus, the induction of epidermal differentiation by Fra-2 is controlled by a du

141 ssion in vivo, we show that miR-203 promotes epidermal differentiation by restricting proliferative p

142 re p63 include epidermal lineage commitment, epidermal differentiation, cell adhesion, and basement m

143 Disrupted epidermal differentiation characterizes numerous disease

144 Altered epidermal differentiation characterizes numerous skin di

145 independent disease-specific loci within the epidermal differentiation complex (chromosome 1q21.3), t

146 Recent studies suggest additional epidermal differentiation complex (EDC) gene association

147 40 integration at 1q21.1, in the vicinity of epidermal differentiation complex (EDC) genes, resulted

148 Numerous epidermal differentiation complex (EDC) genes, such as f

149 The epidermal differentiation complex (EDC) locus comprises

150 The epidermal differentiation complex (EDC) locus consists o

151 iasis, share distinct genetic linkage to the Epidermal Differentiation Complex (EDC) locus on 1q21.

152 with innate defense, including genes in the epidermal differentiation complex (EDC) that regulate ep

153 the higher-order chromatin structure of the epidermal differentiation complex (EDC), a keratinocyte

154 The SMCP gene is located in the epidermal differentiation complex (EDC), a large gene cl

155 This region contains the epidermal differentiation complex (EDC), which consists

156 mal differentiation genes located within the epidermal differentiation complex (EDC).

157 9 transcripts, particularly genes within the epidermal differentiation complex and antimicrobial mole

158 cells regulate the homeostatic expression of epidermal differentiation complex and other skin genes.

159 Decreased epidermal differentiation complex gene expression in mic

160 epidermal maturation, expression of >80% of epidermal differentiation complex genes, and formation o

161 ull epidermis, chromatin architecture of the epidermal differentiation complex locus containing genes

162 racterized an AP-1-dependent enhancer at the epidermal differentiation complex locus that establishes

163 used to screen candidate loci including the epidermal differentiation complex on 1q, the desmoplakin

164 rnified envelope (LCE) genes, located in the epidermal differentiation complex on chromosome 1, encod

165 ion to atopic dermatitis (AD), including the epidermal differentiation complex on chromosome 1q21.

166 S100 multigene family that is encoded in the epidermal differentiation complex on chromosome 1q21.

167 control five subclusters located within the epidermal differentiation complex on chromosome 25; (2)

168 en S100 protein genes are located within the epidermal differentiation complex on human chromosome 1q

169 ified envelope (LCE) gene cluster within the epidermal differentiation complex on human chromosome on

170 e Sprr genes are clustered within the larger epidermal differentiation complex on mouse chromosome 3,

171 alpha and PglyrpIbeta are encoded within the epidermal differentiation complex on mouse chromosome 3F

172 A similar result has been seen for the epidermal differentiation complex region of chromosome 1

173 required for red feathers resides within the epidermal differentiation complex, a cluster of genes in

174 the same co-expression module, mapped to the epidermal differentiation complex, and exhibited differe

175 S100A7/psoriasin, a member of the epidermal differentiation complex, is widely overexpress

176 transcripts including several members of the epidermal differentiation complex, molecules with antimi

177 Twelve mapped to the epidermal differentiation complex, upstream or within ge

178 arrier function, including most genes of the epidermal differentiation complex.

179 genes in 1q21 loci and corresponding to the epidermal differentiation complex.

180 a molecular complex identified in Drosophila epidermal differentiation, comprising Mlpt peptides, ubi

181 expression of JunB and Ras induced premature epidermal differentiation concomitant with upregulation

182 s normalizes cell proliferation and promotes epidermal differentiation, correcting the cutaneous path

183 This increase in epidermal differentiation corresponded to the loss of ma

184 se zymogen activation during early stages of epidermal differentiation, coupled with a loss of matrip

185 st to wild type, this mutant fails to rescue epidermal differentiation defects seen upon Psen1 and 2

186 RIP4(-/-) mice die at birth with epidermal differentiation defects, causing fusions of al

187 ts in EPB defects accompanied by compromised epidermal differentiation, drastic reduction in profilag

188 entified two genes that on knockdown induced epidermal differentiation: ELOVL1, encoding elongation o

189 Abnormal epidermal differentiation-evidenced by positive expressi

190 results suggest that progenitors capable of epidermal differentiation exist in the mesenchymal compa

191 ers has been pivotal to the understanding of epidermal differentiation, function, and renewal.

192 crucial and previously unrecognized role in epidermal differentiation, functioning both to repress p

193 s to hair follicle placodes and can suppress epidermal differentiation gene expression.

194 ive DNA demethylation, are required for full epidermal differentiation gene induction.

195 nalysis showed that a significant portion of epidermal differentiation gene promoters were methylated

196 upregulated in lesional skin and binds known epidermal differentiation gene targets.

197 s suggest that Eig3 is homologous to a human epidermal differentiation gene, XP5, and belongs to a fa

198 istically, Dnmt3a promotes the expression of epidermal differentiation genes by interacting with thei

199 tly or indirectly regulates a broad array of epidermal differentiation genes encoding structural prot

200 Surprisingly, repression of epidermal differentiation genes in JARID2-null keratinoc

201 ic expression of Fra-2 induced expression of epidermal differentiation genes located within the epide

202 d multiple modules of coordinately expressed epidermal differentiation genes, overlapping significant

203 n of cell cycle genes and repression of many epidermal differentiation genes.

204 vealed delayed expression of additional late epidermal differentiation genes: filaggrin, repetin and

205 ontrols epithelial homeostasis by regulating epidermal-differentiation genes, a role underscored by i

206 vels of a transcription factor necessary for epidermal differentiation, GRHL3, at low levels through

207 orting the central role of these pathways in epidermal differentiation, highlighting the integration

208 tinoic acid (RA) signalling is essential for epidermal differentiation; however, the mechanisms by wh

209 In addition to failed epidermal differentiation, IKK-alpha-deficient mice exhi

210 ne trigger of inflammation and impaired late epidermal differentiation in AD.

211 As Dsg1 promotes epidermal differentiation in addition to participating i

212 pically applied PPARalpha activators promote epidermal differentiation in intact adult mouse skin.

213 otein products may play an important role in epidermal differentiation in normal and diseased state.

214 ntal and spatiotemporal cues at the onset of epidermal differentiation in the mouse embryo.

215 ting adult HF-SC maintenance and suppressing epidermal differentiation in the niche.

216 ce, the K14-RIP4 transgene failed to promote epidermal differentiation in these mutant backgrounds.

217 es in vitro induces virtually all aspects of epidermal differentiation in vivo: transcription of corn

218 ic acid (RA) signaling is essential for skin epidermal differentiation including the eyelids.

219 ed with suppression of the genes involved in epidermal differentiation, including genes in 1q21 loci

220 ved in a variety of biological functions as, epidermal differentiation, intracellular signal function

221 As disturbed epidermal differentiation is a main feature of many skin

222 mplex locus containing genes associated with epidermal differentiation is altered primarily at its ce

223 Although commitment to epidermal differentiation is generally considered to be

224 Our understanding of how these genes control epidermal differentiation is incomplete.

225 that, in response to KGF and EGF signalling, epidermal differentiation is promoted at the expense of

226 These studies demonstrate that epidermal differentiation is regulated by liver X recept

227 Thus, epidermal differentiation is required for proper morphog

228 nd differentiation, and KLF4, a regulator of epidermal differentiation, is sufficient to convert derm

229 During epidermal differentiation, keratinocytes sequentially sw

230 is characterized by inflammation and altered epidermal differentiation leading to redness and scaling

231 in caused defects in spindle orientation and epidermal differentiation, leading to neonatal lethality

232 the following mechanisms: (i) stimulation of epidermal differentiation, leading to thickened cornifie

233 downstream of Rho GTPases that contribute to epidermal differentiation, little is known about which u

234 Both tumor sets showed downregulation of epidermal differentiation markers (e.g., profilaggrin, k

235 mors negatively correlate with expression of epidermal differentiation markers and components of the

236 NAM reduces the expression of early and late epidermal differentiation markers and increases the prol

237 All EFNAs induce epidermal differentiation markers and suppress cell adhe

238 follicular hyperplasia and the expression of epidermal differentiation markers in the follicular epit

239 did not modify the expression profile of the epidermal differentiation markers involucrin, keratin 10

240 also induced mRNA and protein expression of epidermal differentiation markers such as keratin 1, ker

241 suppressed the expression of the "classical" epidermal differentiation markers, but strongly and spec

242 Epidermal differentiation markers, including involucrin,

243 Epidermal differentiation markers, including small proli

244 lumab led to a stronger increase in level of epidermal differentiation markers.

245 idermal KCs, and increased the expression of epidermal differentiation markers.

246 spread erythrokeratoderma, with expansion of epidermal differentiation markers.

247 ermis, are similar to each other, expressing epidermal differentiation markers.

248 nstituted human epidermis, a model system of epidermal differentiation, members of the IL-20 subfamil

249 us, the 25OHD 1OHase is essential for normal epidermal differentiation, most likely by producing the

250 During epidermal differentiation, ninein, which is a centrosoma

251 Here, we define epigenomic landscape during epidermal differentiation of human pluripotent stem cell

252 se to dithranol belonged to keratinocyte and epidermal differentiation pathways and IL-1 family membe

253 2+) signaling-dependent systems, such as the epidermal differentiation process, must effectively resp

254 nd by the end of the first growth phase, the epidermal differentiation program is activated in outer

255 The interfollicular epidermal differentiation program was largely unaffected

256 ression requires the master regulator of the epidermal differentiation program, p63.

257 transgene exhibited a striking arrest in the epidermal differentiation program, perishing within 2 we

258 e withdrawal, and proteins that regulate the epidermal differentiation program.

259 l genes encoding important components of the epidermal differentiation program.

260 h due to deficits primarily during the early epidermal differentiation programme and lack of a protec

261 functional role of svRNAs in regulating the epidermal differentiation programme.

262 lysis indicated that disrupted expression of epidermal differentiation programs under the control of

263 The dysregulated expression of epidermal differentiation proteins becomes evident 2 d a

264 We showed further that stimulation of epidermal differentiation provides one mechanism that co

265 es the transcription of a striking number of epidermal differentiation-related genes.

266 EGFR signalling maintains TG activity during epidermal differentiation remains elusive.

267 KLF4 accounted for the majority of disrupted epidermal differentiation resulting from AEC mutant TP63

268 Epidermal differentiation seems to be affected in nkt sk

269 t SREBP signaling plays an essential role in epidermal differentiation, skin barrier formation, hair

270 gene expression programs in the disorders of epidermal differentiation, such as psoriasis and epiderm

271 ates ionic signaling for specific aspects of epidermal differentiation, such as synthesis or processi

272 DC and the transcriptional activation during epidermal differentiation suggested a cis-regulatory mec

273 hypertrophic sebaceous glands, and increased epidermal differentiation, suggesting aberrant cell fate

274 lysis demonstrated MAF:MAFB binding to known epidermal differentiation TF genes whose expression they

275 appaB activity but instead are due to failed epidermal differentiation that disrupts proper epidermal

276 calcium coordinately regulate events late in epidermal differentiation that together form the barrier

277 tor-alpha-/- mice revealed no alterations in epidermal differentiation, the epidermis was thinner in

278 These data suggest that, during epidermal differentiation, the matriptase-prostasin prot

279 ly eliminated from the skin through terminal epidermal differentiation, thereby causing hair follicle

280 domains suggest a role in the regulation of epidermal differentiation through the control of Ca2+-me

281 Although much has been learned about epidermal differentiation through the deciphering of the

282 tly suppress the immune response and enhance epidermal differentiation to restore the barrier.

283 These data suggest that disrupting epidermal differentiation via different pathways can inc

284 y a new role for SIRT3 in the suppression of epidermal differentiation via lowering oxidative stress.

285 in, KLKs are involved in desquamation during epidermal differentiation via proteolytic cleavage of th

286 However, restoration of epidermal differentiation was non-cell autonomous and re

287 However, loricrin, a late marker of epidermal differentiation, was not significantly altered

288 the role of the epithelial sodium channel in epidermal differentiation, we examined skin of mice in w

289 role of the vitamin D receptor in mediating epidermal differentiation, we examined the histomorpholo

290 model system to monitor the course of human epidermal differentiation, we found elevated matriptase

291 nctions of matriptase in normal and aberrant epidermal differentiation, we used enzymatic gene trappi

292 While most of E7's effects on epidermal differentiation were found to require pRb inac

293 he ectoderm has effects on specific steps of epidermal differentiation, which may be amenable to trea

294 Finally, GCs promote terminal epidermal differentiation while simultaneously inhibitin

295 fected by TRAF3IP2 silencing are involved in epidermal differentiation, with early differentiation ge

296 vivo results in a severe defect in terminal epidermal differentiation, with inhibition of XK81A1 epi

297 aspin expression to be closely associated to epidermal differentiation, with low levels in proliferat

298 he p38 inhibitor SB203580 abolished abnormal epidermal differentiation without affecting limbal epith

299 tes p38 MAPK signaling coupled with abnormal epidermal differentiation without intrinsic alteration o

300 ndication of its relevance to skin adhesion, epidermal differentiation, wound healing, scarring, angi