ライフサイエンスコーパス: epididymis

1 al cell populations across the length of the epididymis.

2 ion of the initial segment (IS) of the caput epididymis.

3 ession in other organs, including testes and epididymis.

4 tids, and no spermatozoa are detected in the epididymis.

5 nes, are specifically expressed in the mouse epididymis.

6 lin family and specifically expressed in the epididymis.

7 ression pattern in the developing testis and epididymis.

8 reas, liver, intestines, sweat duct, and the epididymis.

9 ic crypts, pancreatic ducts, bile ducts, and epididymis.

10 in is retained in spermatozoa from the cauda epididymis.

11 embrane in bile ducts, pancreatic ducts, and epididymis.

12 se inhibitor genes that are expressed in the epididymis.

13 d by the time spermatozoa are present in the epididymis.

14 are prematurely released from the testis to epididymis.

15 ulated expression in the caput region of the epididymis.

16 d for concentrating sperm in the head of the epididymis.

17 s are expressed in brain, ovary, testis, and epididymis.

18 e acrosomes of sperm from all regions of the epididymis.

19 with the highest level of expression in the epididymis.

20 art, small and large intestine, stomach, and epididymis.

21 sperm heads during their transit through the epididymis.

22 mporal expression of the mE-RABP gene in the epididymis.

23 n the testis, and in epithelial cells in the epididymis.

24 analysis of the head, body, and tail of each epididymis.

25 sorption of luminal fluid in the head of the epididymis.

26 increasing during sperm transit through the epididymis.

27 rior head once sperm have passed through the epididymis.

28 tinues as the germ cells migrate through the epididymis.

29 revealed that the transgene was expressed in epididymis.

30 ression of these proteins in both testis and epididymis.

31 ed separately during sperm maturation in the epididymis.

32 exhibit androgen-dependent expression in the epididymis.

33 tion, further sperm maturation occurs in the epididymis.

34 rtility through increased IL-6 expression in epididymis.

35 s PH20 hyaluronidase in the adult testes and epididymis.

36 pha expression and transient dilation of the epididymis.

37 at are required for spermatozoa to enter the epididymis.

38 ported transluminally from the testis to the epididymis.

39 rostral mesenchyme of the fallopian tube and epididymis.

40 scribe its occasional uptake patterns in the epididymis.

41 d 50% of these mice had no sperm in the left epididymis.

42 n testes as well as with mature sperm within epididymis.

43 tion, is a newly discovered function for the epididymis.

44 ast-investigated organ in a man's body - the Epididymis.

45 increase in abundance as sperm mature in the epididymis.

46 sperm centriole reduction occurs within the epididymis.

47 ion during their lengthy travels through the epididymis.

48 ct and the vas deferens anteriorized towards epididymis.

49 f may undergo maturational changes along the epididymis.

50 egulated during postnatal development of rat epididymis.

51 egulated during postnatal development of rat epididymis.

52 ein (EGFP) exclusively in these cells in the epididymis.

53 helium, and lack of mature spermatids in the epididymis.

54 mation, and sperm granuloma formation in the epididymis.

55 reproductive tracts, the oviduct and ductus epididymis.

56 the presence of abnormal spermatozoa in the epididymis.

57 um in the anterior Wolffian duct, the future epididymis.

58 icant levels of PC mRNA were detected in the epididymis (1.7% of the level in liver), brain (1.1% of

59 number of secreted factors, including human epididymis 4 (HE4).

60 plasma membrane of specialized cells in the epididymis (9), which closely resemble acid-secreting ki

61 presence of cSrc in mature sperm from cauda epididymis, a closer evaluation indicates that this tyro

62 Using in vivo microscopy to visualize the epididymis, a model system for the study of pseudostrati

63 vous system resulted in recombination in the epididymis, a tissue where sperm mature for ~1-2 weeks f

64 d Rnase12, are specifically expressed in the epididymis-a long, convoluted tubule where sperm mature

65 f unknown function, is expressed only in the epididymis after onset of sexual maturity.

66 were replicated in narrow/clear cells in the epididymis, also part of the MRC family.

67 entiation of the Wolffian duct (WD) into the epididymis, an essential organ for male reproduction, by

68 npp5b was expressed in the Sertoli cells and epididymis and at low levels in the developing germ cell

69 onstrated an accumulation of disaccharide in epididymis and brain.

70 ac tumors, and papillary cystadenomas of the epididymis and broad ligament.

71 has a distinct spatial expression within the epididymis and different regulation.

72 Hoxa-10 mutant males at the junction of the epididymis and ductus deferens.

73 rRNA-derived small RNAs or rsRNAs) in the KO epididymis and epididymal luminal fluid, although RNases

74 epididymis; Eppin-2 is expressed only in the epididymis and Eppin-3 only in the testis.

75 maturation and function, like the mammalian epididymis and female reproductive tract.

76 d have no detectable ADH4 enzyme activity in epididymis and low levels in seminal vesicle, ovary and

77 (nNOS-IR) nerve fibers and somata in the rat epididymis and major pelvic ganglia was studied by immun

78 lved in sugar efflux from intestinal, liver, epididymis and mammary cells.

79 sregulation in Ca(2+) homeostasis within the epididymis and sperm as the main factor responsible for

80 ZIKV results in severe damage to the testes, epididymis and sperm.

81 lar ATP is essential for the function of the epididymis and spermatozoa, but ATP release in the epidi

82 ine protease inhibitors, is expressed in the epididymis and spermatozoa, suggesting specialized roles

83 ome of the Eppin-like genes is restricted to epididymis and testis while others are expressed in seve

84 ues identified Eppin transcripts only in the epididymis and testis.

85 he apical membrane of principal cells of the epididymis and the vas deferens, and that both NHERF1 an

86 aintaining sperm in an immotile state in the epididymis and vas deferens (2,4-6).

87 le reproductive complex is restricted to the epididymis and vas deferens and never invades the interi

88 Clear cells of the epididymis and vas deferens contain abundant V-ATPase in

89 nial end of the Wolffian duct and formed the epididymis and vas deferens, but failed to elaborate the

90 than three times as frequent in testis than epididymis and vas deferens, highlighting the transcript

91 generated a single-cell atlas of the murine epididymis and vas deferens.

92 om the Pp were only detectable in testis and epididymis and were only expressed in epididymis in the

93 riole pairs in the upper caput region of the epididymis and, the destruction, first, of the distal an

94 t epididymal sperm (sperm in the head of the epididymis), and we further determined that the changes

95 ood and several other tissues, including the epididymis, and a testis-specific isozyme (testis ACE) f

96 se was highly expressed in testis, pancreas, epididymis, and brain.

97 sympathetic paraganglia, endolymphatic sac, epididymis, and broad ligament.

98 s were also detected in lung bronchioli, the epididymis, and liver.

99 s selectively expressed in placenta, testis, epididymis, and ovary.

100 n the sonograms, five masses were within the epididymis, and six were distinct from it; seven cases w

101 itative polymerase chain reaction of the DE, epididymis, and testis showed elevations in the levels o

102 t of Aire to promote immune tolerance to the epididymis, and that its disruption causes an imbalance

103 V virus can infect and damage the testis and epididymis, and these results has been correlated to low

104 expression and splicing variation in testis, epididymis, and vas deferens transcriptomes of 118 matur

105 tral and dorsal prostate, coagulating gland, epididymis, and vas deferens.

106 lial cells release ATP into the lumen of the epididymis, and we examined the role of the cystic fibro

107 t reports that sperm obtained from the mouse epididymis are contaminated with low levels of cell-free

108 ncluded that nNOS-IR nerve fibers in the rat epididymis arise mainly from neurons in the major pelvic

109 n up new directions of exploration using the epididymis as a model for tubular morphogenesis.

110 Using the epididymis as a model system in which luminal acidificat

111 In the present study, we used the epididymis as a model system to investigate epithelial c

112 antial differences in distribution along the epididymis as further assessed by flow cytometry and imm

113 rentes (DE; ducts linking the rete testis to epididymis) as early as age 30 days.

114 ertiary lymphoid structures (TLS) within the epididymis, as indicated by the presence of B and T cell

115 Thus, detection of flow in the epididymis at color Doppler imaging can be a normal find

116 natomical structures, such as the testis and epididymis, at a spatial resolution <50 um.

117 fferent ducts and lack of spermatozoa in the epididymis (azoospermia).

118 r Pten deletion, hypertrophy of the proximal epididymis became evident.

119 e findings highlight the contribution of the epididymis beyond fertilization and identify CRISP1 and

120 scrotum, with normal dimensions and a normal epididymis bilaterally.

121 em (CNS), kidneys, pancreas, adrenal glands, epididymis, broad ligament, and the endolymphatic sac/pe

122 gene, r.Pem2, is expressed at high levels in epididymis but not in any other tissues that express the

123 hough r.Pem2, is expressed at high levels in epididymis but not in any other tissues that express the

124 mulate in the caput and cauda regions of the epididymis but not in the initial segment.

125 rane of most sperm from the corpus and cauda epididymis, but on only 6% of caput epididymal sperm.

126 on of newborn (1 day) and adult (90 day) rat epididymis by microarray analysis, and found that the le

127 F-binding site, was evident in primary human epididymis cells that express abundant CFTR mRNA.

128 Moreover, we reveal that in primary epididymis cells, the +6.8 kb DHS interacts closely with

129 ire this binding in the corpus region of the epididymis, correlating with the developmental stage at

130 Src are infertile and exhibit improper cauda epididymis development.

131 Pem expression in the epididymis did not depend on spermatozoa in the lumen of

132 essential function causes sperm to enter the epididymis diluted, rather than concentrated, resulting

133 The Dicer1 cKO epididymis displayed an altered lipid homeostasis associ

134 rous tubules in the testes, caput and corpus epididymis do not reveal obvious defects.

135 ciliated epithelial cells of: lung, oviduct, epididymis, ductus deferens, and seminiferous tubules.

136 In the epididymis, elaborate communication networks between epi

137 In the epididymis, elaborate communication networks between the

138 matory infiltrates in the testis (orchitis), epididymis (epididymitis), and vas deferens (vasitis).

139 Eppin-1 is expressed only in the testis and epididymis; Eppin-2 is expressed only in the epididymis

140 The few that survive to populate the epididymis exhibit head abnormalities similar to those d

141 ulthood, with the uncoiled corpus and caudal epididymis exhibiting abnormal epithelial morphology and

142 In the absence of Inhba, the epididymis failed to develop the characteristic coiling

143 d peri-tubular fibrosis were observed in the epididymis following clearance of virus.

144 testis require functional maturation in the epididymis for their full competence.

145 t regulate region-specific expression in the epididymis, for expressing and conditionally knocking ou

146 ing out genes in different subregions of the epididymis, for treating male infertility, and for gener

147 Based on reports that human epididymis four (HE4) / creatinine (CRE) ratios found in

148 Sperm count and motility in epididymis from AR(-/y) mice are similar to that of WT (

149 en from the epithelial cells of the proximal epididymis from postnatal day 17 (P17) onward.

150 The epididymis functions as transition zone for post-testicu

151 maturation and survival of spermatozoa, the epididymis has a complex immune function.

152 ulated during postnatal development of mouse epididymis, heart, liver, and lung.

153 PM-AR-/y mice have oligozoospermia in the epididymis; however, fertility was normal.

154 f Boo was highly restricted to the ovary and epididymis implicating it in the control of ovarian atre

155 aculation, mammalian sperm are stored in the epididymis in a "resting" metabolic state.

156 it was shown that the lack of expression in epididymis in C57BL/6 mice is cis-acting in F(1) hybrid

157 To understand the roles for the epididymis in reproductive biology, we generated a singl

158 ression was seen within lumenal cells of the epididymis in the absence of tropoelastin.

159 is and epididymis and were only expressed in epididymis in the presence of testosterone.

160 ctate regionally localized expression in the epididymis in vivo.

161 ression in different subregions of the mouse epididymis in vivo.

162 In the epididymis, in which luminal acidification is crucial fo

163 The epididymis is a useful model system to understand the me

164 tubule of the male reproductive system, the epididymis is proving to be a key determinant of male fe

165 However, the cauda epididymis is significantly smaller, and expression of k

166 human sperm is morphologically mature in the epididymis, it cannot fertilize eggs before capacitation

167 of Aire results in autoimmune attack of the epididymis leading to fibrosis, iron deposition, and cop

168 and progression of spermatozoa in the cauda epididymis, leading to infertility in male mice.

169 AQP9 is the major aquaglyceroporin of the epididymis, liver, and peripheral leukocytes, and its CO

170 tis-derived secreted signals relocate to the epididymis lumen and promote functional differentiation.

171 ial segment, the most proximal region of the epididymis, male infertility results.

172 propose that defective ATP signalling in the epididymis might contribute to dysfunction of the male r

173 As in rat epididymis, miR-29a was up-regulated and Nasp was down-r

174 Conclusion: [(68)Ga]Ga-FAPI-46 uptake in the epididymis occurs occasionally and does not appear relat

175 rous tubules and epithelial cells lining the epididymis of -/- mice.

176 However, spermatozoa isolated from the cauda epididymis of Cyt c(T)-null animals were less effective

177 FUT2 null mice and from the epithelia of the epididymis of FUT1 null mice.

178 lated dengue virus (DENV), in the testis and epididymis of male mice, and this was associated with ti

179 in the spermatozoa collected from the cauda epididymis of Ncoa5(+/-) mice.

180 of Bmp8a null mutants in spermatogenesis and epididymis of the adult.

181 sful application to sperm retrieved from the epididymis or testis have made biological paternity poss

182 ding sites typical of genes expressed in the epididymis or testis.

183 directs expression in kidney, adrenal, lung, epididymis, ovary and skin but promotes ectopic expressi

184 d five peripheral tissues (adrenals, testes, epididymis, pancreas and prostate) were analyzed.

185 tudy, functional analysis of the mouse cauda epididymis perfused in vivo showed that luminal ATP and

186 Epididymis, playing important roles in sperm maturation,

187 Numerous reports showed that the epididymis plays key roles in the acquisition of sperm f

188 These data demonstrate that the epididymis possesses a specific mechanism to identify an

189 age-dependent manner against sperm, testis, epididymis, prostate gland, and seminal vesicle.

190 n as epithelial Ca(2+) entry pathways in the epididymis, prostate, and placenta.

191 Human epididymis protein 4 (HE4) is highly overexpressed in wo

192 analysis, we have determined that high human epididymis protein 4 (HE4) production correlates with mu

193 tion of cancer antigen 125 (CA125 II), human epididymis protein 4 (HE4), and interleukin 6 (IL6), wit

194 ts analogs decreases the expression of human epididymis protein 4 (HE4), which is commonly upregulate

195 arian carcinomas (EOC) is the gene for human epididymis protein 4 (HE4).

196 cancer antigen 125 (CA125, 0.842) and human epididymis protein 4 (HE4, 0.717).

197 e addition of novel biomarkers such as human epididymis protein 4 to the use of CA125 improves the se

198 l validation to identify HE4 (encoding human epididymis protein 4, also known as WAP 4-disulfide core

199 de core domain 2 (WFDC2; also known as human epididymis protein 4; HE4) were consistent mediators.

200 tifiers, we pinpoint epithelial cells of the epididymis (rather than cells of the testis, vas deferen

201 s were reviewed to determine the presence of epididymis-related disease.

202 ymis and spermatozoa, but ATP release in the epididymis remains uncharacterized.

203 d strong LacZ expression in the placenta and epididymis, respectively, both of which are tissues that

204 secreted by the initial segment of the caput epididymis, resulting in SED1 localization on the sperm

205 , and, in situ hybridization analysis of the epididymis revealed that fgl2 mRNA exhibited a region- a

206 Human epididymis secretory protein 4 (HE4) is a newly discover

207 sequence analysis identified the HE2 (human epididymis secretory protein) gene 17 kb upstream from t

208 ously known to be secreted by keratinocytes (epididymis secretory protein, maspin, and anti-neoplasti

209 Lymphocytic infiltration into the epididymis, seminal vesicle, and prostate gland was evid

210 eam sequence directs u-PAR expression in the epididymis, sequences located between -0.4 and -1.5 kb a

211 The epididymis serves a critical function of preparing the m

212 oblots of fertilin from seven regions of the epididymis showed a temporal correlation between the beg

213 y processed during sperm transit through the epididymis, showed reduced levels of processing in the I

214 known as WFDC2), originally described as an epididymis specific protein but more recently suggested

215 er of genes involved in immune processes and epididymis-specific genes were upregulated in the testes

216 ur results reveal an unexpected role of four epididymis-specific noncanonical ribonuclease A family g

217 caca radiata) immunized with Eppin, a testis/epididymis-specific protein.

218 the levels of tRFs, demonstrating a role of epididymis-specific Rnase9-12 genes in regulating sperm

219 loid tissues also express hCAP-18, including epididymis, spermatids, keratinocytes, epithelial cells,

220 presented with marked calcifications in the epididymis, spermatogenic arrest, and focally germ cells

221 fies a lumicrine system essential for testis-epididymis-spermatozoa (NELL2-ROS1-OVCH2-ADAM3) signalin

222 ifferently regulated and regionalized in the epididymis, strongly suggests that these proteins may pl

223 inase is not present in sperm from the caput epididymis, suggesting that this protein is acquired by

224 acellular and nonpathological amyloid in the epididymis suggests that similar amyloid structures may

225 the hepatic biliary ducts, pancreatic ducts, epididymis, sweat ducts, colonic crypts, and gallbladder

226 The murine epididymis synthesizes and secretes a retinoic acid-bind

227 n factors in somatic cells of the testis and epididymis that could potentially regulate androgen-depe

228 with the three-dimensional coiled postnatal epididymis that is comprised of several distinctly funct

229 ximal cauda and distal corpus regions of the epididymis, the regions where spermatozoa gain forward m

230 t show obvious defects in the testis and the epididymis, the role of Bmp7 in spermatogenesis and epid

231 In the epididymis, the supply of nNOS-IR fibers was highest in

232 In the distal epididymis, these spermatozoa appear to lack calcium-dep

233 be trafficked from its cell of origin to the epididymis through the circulatory system.

234 Further analysis of testis and epididymis tissue sections demonstrated that only epithe

235 In order for the epididymis to carry out this role it must undergo a high

236 dependent on the environment of the proximal epididymis to complete their maturation; however, no spe

237 eling in mouse sperm isolated from the cauda epididymis to follow glucose metabolism through central

238 h the male and female, including the testes, epididymis, uterus, ovary, and fallopian tube.

239 As a result, the epididymis, vas deferens and efferent ductules were larg

240 s differentiation of Wolffian ducts into the epididymis, vas deferens and seminal vesicle.

241 f regionally specific structures such as the epididymis, vas deferens, and seminal vesicle from a str

242 etaplasias were detected in epithelia of the epididymis, vas deferens, coagulating gland, preputial g

243 Here, epididymis was employed as a model to explore the underl

244 expression in epithelial cells of Ncoa5(+/-) epididymis was higher than wild type counterparts.

245 ydroxylase (TH)-immunoreactive fibers in the epididymis was similar but the latter was generally more

246 The epididymis was surgically absent in the remaining patien

247 of Dicer1 in the proximal part of the mouse epididymis, we studied the role of RNA interference in e

248 Similarly, nNOS-IR fibers in the epididymis were mostly VIP-positive and TH-negative.

249 not only observed reporter expression in the epididymis when Cre expression was driven from neuron-sp

250 luminal fluid and cytosols of the testis and epididymis when the intercellular junctions were not pre

251 tain the tolerogenic state of the testis and epididymis, where sperm are produced and mature.

252 icer1 is critical for lipid synthesis in the epididymis, which directly affects sperm membrane integr

253 ature in a long epithelial tube known as the epididymis, which plays key roles in remodeling sperm pr

254 al regionalization of the fallopian tube and epididymis, which probably contribute to sperm maturatio

255 lar to sperm freshly isolated from the cauda epididymis; while in the other half fertilin was highly

256 rally enlarged echogenic kidneys, testis and epididymis with echogenic peritoneal fluid tracking into

257 - exhibited off-target recombination in the epididymis, with a subset of drivers also exhibiting une