ライフサイエンスコーパス: epigenetic

1 ial far-reaching implications for behavioral epigenetics.

2 rmation coded by the sequence, process named epigenetics.

3 mic approaches, we sought to distinguish the epigenetic activation mechanisms downstream of TGFbeta t

4 methyltransferase 5 (PRMT5) functions as an epigenetic activator of AR transcription in CRPC, requir

5 stress in adulthood through region-specific epigenetic activity and catecholamine levels.

6 D supplementation was associated with lower epigenetic age acceleration (-8.1 wk; 95% CI: -14.5, -1.

7 Maternal intakes of saturated fat [6.2 wk epigenetic age acceleration (95% CI: 1.0, 11.3) per 5% o

8 ergy; P = 0.003] were associated with higher epigenetic age acceleration in the newborn.

9 Epigenetic age acceleration was associated with aortic i

10 Epigenetic age acceleration was not associated with hear

11 fants [1.0 um (95% CI: 0.2, 1.8) per week of epigenetic age acceleration; P = 0.01], but not among th

12 Epigenetic age results were confirmed in an independent

13 types of cancer point to the significance of epigenetic aging in tumorigenesis and its potential use

14 al dietary macronutrient intake, and whether epigenetic aging is associated with cardiovascular healt

15 also changes over a lifetime as part of an "epigenetic aging" process.

16 mine the early-life risk factors for newborn epigenetic aging, specifically maternal dietary macronut

17 y, we investigated the hypothesis that these epigenetic alterations act in a feed-forward fashion to

18 ks of 2i exposure, but it is unclear whether epigenetic alterations are required to achieve and maint

19 ese exposures can not only cause genetic and epigenetic alterations in colorectal epithelial cells bu

20 Our findings highlight unique and shared epigenetic alterations in histone modifications and pote

21 In addition, a substantial portion of epigenetic alterations in schizophrenia and related diso

22 mmarize clinical and preclinical findings of epigenetic alterations in schizophrenia and relevant dis

23 to the chromatin and associates with massive epigenetic alterations on the DNA methylation, chromatin

24 We propose that the observed epigenetic alterations reflect distinct differentiation

25 is characterised by a series of genetic and epigenetic alterations that result in deregulation of tr

26 , host-pathogen interactions often result in epigenetic alterations to host cells that favor pathogen

27 Cancers result from a set of genetic and epigenetic alterations.

28 We performed epigenetic analyses of BE and EAC tissues and combined t

29 Epigenetic analyses reveal that histone modifications, b

30 Epigenetic analyses revealed that T(RM) cells align clos

31 ibit subclonal heterogeneity at the genomic, epigenetic and phenotypic levels.

32 Epigenetic and transcriptional changes also contribute t

33 a reversion of a given cell to a fetal-like epigenetic and transcriptional state.

34 tone deacetylases (HDACs) are key enzymes in epigenetics and important drug targets in cancer biology

35 y and critical periods of brain development; epigenetics and the molecular underpinnings of biologica

36 quire a deeper understanding of the genetic, epigenetic, and developmental factors driving these canc

37 They describe how genetics, epigenetics, and the 3D genome architecture are coordina

38 mechanistic understanding of the genetic and epigenetic architecture of reaction severity in peanut a

39 he regulation of the chromatin landscape and epigenetic barriers that must be overcome for cardiac re

40 Herein, we highlight how the study of the epigenetic basis of tick biology and vectorial capacity

41 of RNA-binding proteins can drive a form of epigenetics beyond the chromosome, instilling adaptive g

42 , brain, and behavioral indicates that these epigenetic biomarkers may serve as complementary measure

43 ility and gene expression revealed extensive epigenetic but not transcriptional priming of HSCs/MPPs

44 icity and highlight how patient genetics and epigenetics can facilitate researchers and clinicians in

45 of the long-term stability of CENP-A ensures epigenetic centromere inheritance.

46 Among several reversible epigenetic changes occurring during transcriptional acti

47 important approach for profiling genome-wide epigenetic changes such as histone modifications.

48 Understanding genetic and epigenetic changes that underlie abnormal proliferation

49 To account for these non-linear epigenetic changes with age, we recently developed a for

50 een reported, including somatic alterations, epigenetic changes, and changes in the tumor microenviro

51 n, telomere shortening, genomic instability, epigenetic changes, protein aggregation, and down-regula

52 ell commitment is accompanied by large scale epigenetic changes, we observed that the majority of dis

53 tion, proliferation, cytotoxic function, and epigenetic changes.

54 s of these effects, focusing on long-lasting epigenetic changes.

55 fmann et al (2020) now uncover that when the epigenetic chromatin cycle falters, a genetically hardwi

56 This study aimed to generate a novel epigenetic clock in rats-a model with unique physical, p

57 We performed a comprehensive analysis of 14 epigenetic clocks categorized according to what they wer

58 evelop biomarkers of ageing, referred to as 'epigenetic clocks', which have been widely used to ident

59 , thereby establishing the robustness of the epigenetic code.

60 ytic functions that regulate the assembly of epigenetic complexes in cells.

61 igated whether all sperm cells have a common epigenetic configuration that primes transcriptional pro

62 Consistent with epigenetic conflict, donor genes mapped more siRNAs and

63 sticity regulated by TGFbeta stimulation and epigenetic control affects EGFR-TKI tolerance and cancer

64 e of nuclear events in autophagy regulation, epigenetic control of autophagy gene transcription remai

65 Here, we investigated the epigenetic control of EndMT.

66 's disease (PD) pathogenesis may involve the epigenetic control of enhancers that modify neuronal fun

67 on analysis suggested a role for partial cis-epigenetic control of protein expression with age.

68 Decorate, differential epigenetic correlation test, identifies correlated epige

69 indicate that the integration of genetic and epigenetic data can facilitate better understanding of b

70 Such deleterious alterations, including epigenetic drift, irreversibly accumulate in a stepwise,

71 NA methylome remains stable despite constant epigenetic drift.

72 These epigenetic drugs have been widely described as potent cy

73 Preclinical studies suggest epigenetic dysregulation, including altered DNA methylat

74 ypoxia that drive the tumor's characteristic epigenetic dysregulation.

75 PTEN silencing with CRISPR/dCas9 epigenetic editing may provide a new option for promotin

76 scribe CRISPR/dCas9-based enhancer-targeting epigenetic editing systems, enCRISPRa and enCRISPRi, for

77 er, florigen BdFTL2 functions as a potential epigenetic effector of BdFTL1 by interacting with a BdES

78 to assemble, regulate, and deliver multiple epigenetic effectors that maximize the longevity of the

79 e common to both sets, suggesting comparable epigenetic effects of thyroid hormone on both the male a

80 Complex interaction between genetics, epigenetics, environment, and nutrition affect the physi

81 e potential use of systemically administered epigenetic enzyme inhibitors for relapse prevention in h

82 ion, and provide a comprehensive overview of epigenetic enzymes and transcription factors that are in

83 associates with progressive accumulation of epigenetic errors that eventually lead to aberrant gene

84 , and food source are eliminated, leaving an epigenetic factor as a main cause for variability in thi

85 CXXC5, suggested as transcription and/or epigenetic factor, participates in cellular proliferatio

86 modifications correlate with pA site usage, epigenetic factors potentially affect alternative polyad

87 etic correlation test, identifies correlated epigenetic features and finds clusters of features that

88 red mechanism offers robustness to a dynamic epigenetic feedback loop ensuring long-term centromere i

89 iated enhancer silencing as a cell-intrinsic epigenetic feedback mechanism by which the duration of t

90 Naive culture conditions minimize epigenetic fluctuation, potentially overcoming differenc

91 define the links between genetic variation, epigenetic gene regulation, and atrial function.

92 f transcriptomic data demonstrates extensive epigenetic gene silencing of the transcription factor PR

93 y even be transmitted across generations via epigenetic germline inheritance.

94 extensively, leading to transcriptional and epigenetic heterogeneity of macrophages in atherosclerot

95 indicate that Cdk1 functions to maintain the epigenetic identity of ESCs.

96 ts to identify changes in paternal germ cell epigenetics in association with offspring disease risk,

97 ssion in early sepsis, suggesting a role for epigenetics in coordinating the response to infection.

98 d DNA from Eschericia coli, phosphorothioate epigenetics in Salmonella enterica Cerro 87, and oxidati

99 nd clinical diagnosis may suggest a role for epigenetics in T1D pathogenesis; however, functional val

100 The contribution of epigenetics in this process remains unknown.

101 ms that allow organisms to adapt and protect epigenetic information during life-experienced fluctuati

102 ription of trans-generational inheritance of epigenetic information in mammals.

103 we uncover a conserved mechanism of paternal epigenetic information transmission to the embryo throug

104 ese enzymes catalyze reactions that regulate epigenetic inheritance via histone post-translational mo

105 ain insight into the mechanisms that mediate epigenetic inheritance, we used a Schizosaccharomyces po

106 ariation and putative paradigms of mammalian epigenetic inheritance.

107 onmental adaptability, and transgenerational epigenetic inheritance.

108 a greater understanding of intergenerational epigenetic inheritance.

109 omising targets for the development of novel epigenetic inhibitors for biomedical applications.

110 nt premature differentiation and controlling epigenetic integrity.

111 ely managed in order to preserve genetic and epigenetic integrity.

112 ors or their binding sites and/or regulating epigenetic intermediates controlling HbF expression.

113 portant clinical implications of genetic and epigenetic ITH in LUAD.

114 HUSH recruits effectors that alter the epigenetic landscape and chromatin structure, but how HU

115 priming factors that establish a permissive epigenetic landscape at a subset of developmentally impo

116 that N(6)-mA has a key role in changing the epigenetic landscape during cell fate transitions in ear

117 aches to study the structure, expression and epigenetic landscape of 35S rDNA in an allotetraploid gr

118 The epigenetic landscape of the region, and Hi-C RO data, sh

119 n compaction, 3D genome organization and the epigenetic landscape.

120 n suppression, which correlates with altered epigenetic landscapes and can be overcome by wild introg

121 ulate gene transcription by remodeling local epigenetic landscapes at sgRNA-targeted enhancers and as

122 At the epigenetic level, global hypermethylation is the dominan

123 ecent studies documented 8-oxoG serves as an epigenetic-like mark and OGG1 modulates gene expression

124 then sufficient to initiate the CENP-A-based epigenetic loop.

125 Epigenetic machinery permits mammalian cells to integrat

126 n considered that target transcriptional and epigenetic machinery, cooperating alterations, and signa

127 ork for understanding the molecular basis of epigenetic maintenance mediated by Polycomb-group protei

128 LSD1 demethylates histone H3 Lys4, an epigenetic mark for active genes, but requires the CoRES

129 3 variant centromere protein A (CENPA) is an epigenetic mark that determines centromere identity.

130 DNA methylation is an epigenetic mark with important regulatory roles in cellu

131 DNA methylation, a prominent epigenetic mark, also changes over a lifetime as part of

132 FKBP5 knockout mice play a potential role as epigenetic markers of PTSD.

133 We explored whether the epigenetic markers, circulating microRNAs (miRNAs), were

134 -liquid phase separation orchestrated by the epigenetic marking and operated by proteins that bind to

135 FACT knockdown also increases epigenetic marking by dCas9-based transcriptional effect

136 RA-regulated epigenetic marks were identified near RA target genes al

137 rated events, including extensive changes in epigenetic marks, allow a somatic nucleus to become toti

138 l offers novel workflows for the analysis of epigenetic marks, time series experiments, and single ce

139 ian genes based on parent-of-origin specific epigenetic marks.

140 nic neural development and uncover a crucial epigenetic mechanism balancing forebrain-hindbrain linea

141 The traditional approach to studying the epigenetic mechanism CpG methylation in tissue samples i

142 Collectively, our findings support a non-epigenetic mechanism for 5-AzadC-induced re-expression o

143 We further showed that this epigenetic mechanism has a role in glucose starvation-in

144 ether, our findings reveal a key role and an epigenetic mechanism of action of NONO in regulation of

145 inal (BET) protein activation is a druggable epigenetic mechanism of disease pathogenesis in this her

146 H3K9 tri/di-demethylation is an important epigenetic mechanism responsible for silencing of gene e

147 y the presence of PTC, hinting at a possible epigenetic mechanism responsible for this process.

148 Our findings reveal an epigenetic mechanism with etiological and therapeutic im

149 Here, we review studies that have examined epigenetic mechanisms (e.g., histone modifications, chro

150 ons in T cells, but the nature of underlying epigenetic mechanisms and any normal purpose in T cell d

151 illustrate the cross-talk between different epigenetic mechanisms during chondrocyte differentiation

152 Although various genetic and epigenetic mechanisms have been identified, the full mol

153 ers, MAALIN is regulated by a combination of epigenetic mechanisms including DNA methylation and chro

154 a cell type specific manner orchestrated by epigenetic mechanisms including DNA methylation.

155 The main focus of these studies has been epigenetic mechanisms of psychomotor sensitization and d

156 Lastly, we suggest that targeting epigenetic mechanisms opens therapeutic routes for heter

157 d define the molecular, transcriptional, and epigenetic mechanisms that could provide opportunities t

158 cles, these arthropods likely evolved robust epigenetic mechanisms that provide sustainable responses

159 This discovery implies that epigenetic mechanisms, and their effect on gene expressi

160 Epigenetic mechanisms, including DNA methylation, histon

161 During differentiation, epigenetic memory and persistent looping are maintained

162 T cell epigenetic memory can persist long-term, contributing to

163 e memory, which is associated with long-term epigenetic, metabolic, and functional reprogramming.

164 train, suggesting a correlation between this epigenetic modification and silencing of Avr1b.

165 e receptor promoter regions, suggesting that epigenetic modification of germ cell DNA may mediate tra

166 DNA methylation is an epigenetic modification that specifies the basic state o

167 transcription, replication, DNA repair, and epigenetic modification, chromatin forms the nexus of mo

168 Aberrant changes in epigenetic modifications are closely involved in drug re

169 Epigenetic modifications are increasingly recognized to

170 However, it remains elusive how these epigenetic modifications crosstalk.

171 rrent methods do not allow direct readout of epigenetic modifications from a single read.

172 e proinflammatory cytokines, and exhibit the epigenetic modifications of the FOXP3 gene enhancer CNS2

173 Epigenetic modifications on chromatin play important rol

174 e intricate, diverse, and dynamic roles that epigenetic modifications play in plant-nematode interact

175 In addition, we demonstrated epigenetic modifications that might be responsible for t

176 ses to pregnancy, altered maternal behavior, epigenetic modifications, or a combination of mechanisms

177 t govern the heritability and maintenance of epigenetic modifications.

178 proaches for intervention by targeting these epigenetic modifications.

179 -bias, and demonstrating direct detection of epigenetic modifications.

180 EST binding to the TH promoter recruited the epigenetic modifier cAMP-response element-binding protei

181 Here we describe chemical epigenetic modifiers (CEMs) designed to activate the exp

182 In human sepsis patients, multiple epigenetic modifying enzymes show differential expressio

183 er-dose azacitidine, linked to more specific epigenetic modulation.

184 y of the findings revealed associations with epigenetic modulations of genes regulating neurotransmis

185 Therapeutic targeting of epigenetic modulators offers a novel approach to the tre

186 derived from PTCs may have both genetic and epigenetic origins, and may be desirable or degrade the

187 Hence, circadian clock-pituitary epigenetic pathway interactions form the basis of the ma

188 hylation markers is important in identifying epigenetic pathways between environmental exposures and

189 s a powerful approach to compare genetic and epigenetic pathways in human and mouse neurons.

190 ollowed by a maintenance phase when multiple epigenetic pathways lock down the inactive X (Xi) state.

191 ate gene expression, play important roles in epigenetic pathways, and are hypothesized to contribute

192 X-chromosome inactivation (XCI) are classic epigenetic phenomena that involve transcriptional silenc

193 Genomic imprinting is an epigenetic phenomenon leading to parental allele-specifi

194 Epigenetic plasticity is a pivotal factor that drives me

195 pluripotency associated 2 and 4 (DPPA2/4) as epigenetic priming factors that establish a permissive e

196 sents the initial step to expose the role of epigenetic process, in the production of symptoms associ

197 Epigenetic processes govern prostate cancer (PCa) biolog

198 ch outcomes are affected by molecular, often epigenetic, processes involving gene-environment (G-E) i

199 at these perturbations may be due to altered epigenetic profiles and chromatin accessibility but the

200 sion at different genomic loci with multiple epigenetic profiles including the enrichment of transcri

201 air cell-like morphology, transcriptomic and epigenetic profiles, electrophysiological properties, me

202 selection also manifests in cellular states, epigenetic profiles, spatial distributions and interacti

203 uantitative trait loci, elucidated by direct epigenetic profiling of specific human tissues, may cont

204 atiotemporal expression of Phf21b creates an epigenetic program that triggers neural stem cell differ

205 s, stemness, transcriptional activation, and epigenetic programming via signaling that is often indep

206 se cells could be mediated, in part, through epigenetic programs.

207 polycomb group protein CBX2 is an important epigenetic reader involved in cell proliferation and dif

208 e/macrophages, cellular settings where these epigenetic reader proteins couple proximal stimuli to ch

209 and BRD4 and the testis-restricted BRDT, are epigenetic reader proteins that bind to specific acetyla

210 Both the extracellular matrix (ECM) and DNA epigenetic regulation are critical for maintaining stem

211 should lead to an improved understanding of epigenetic regulation by DNA methylation.

212 Epigenetic regulation has a profound influence on stem c

213 To further our understanding of epigenetic regulation in chondrocytes we characterised t

214 cancer metabolism and indirect modulator of epigenetic regulation in GBM.

215 Epigenetic regulation is a key determinant of gene expre

216 number of human sepsis studies, suggest that epigenetic regulation may play a central role in the pat

217 We show that permissive epigenetic regulation of cldn5 expression and low endoth

218 d provide new insights into the PcG-mediated epigenetic regulation of climacteric fruit ripening.

219 icating convergence of oxygen signaling with epigenetic regulation of gene expression.

220 to hypoxia, extracellular matrix formation, epigenetic regulation of gene transcription and the repr

221 Epigenetic regulation of gene transcription has been sho

222 GCN5 loss-of-function on the expression and epigenetic regulation of its target genes.

223 ions of those properties were dependent upon epigenetic regulation of key VSMC differentiation genes;

224 y acid metabolism, likely descriptive of the epigenetic regulation of metabolism in early-postpartum

225 roenvironmental changes, and metastasis, the epigenetic regulation of NF-kappaB in tumor context is l

226 Here we identify epigenetic regulation of nucleotide-binding leucine rich

227 s a promising strategy to combat HGG through epigenetic regulation of the MYC oncogenic pathway.

228 n extensively studied, little is known about epigenetic regulation of these processes.

229 ork reveals a key role for TAD remodeling in epigenetic regulation of transcription and delivers the

230 Epigenetic regulation orchestrates many cellular process

231 Recently, transcriptional and epigenetic regulations of autophagy have emerged as esse

232 DNA methylation (DNAm) is an epigenetic regulator of gene expression programs that ca

233 ine missense or nonsense variants in a known epigenetic regulator of gene expression: ten-eleven tran

234 ation of 5-methylcytosine (5mC), the central epigenetic regulator of mammalian DNA.

235 ur results identify TEX15 as a new essential epigenetic regulator that may function as a nuclear effe

236 in protein 4 (BRD4) is a transcriptional and epigenetic regulator with intrinsic kinase and histone a

237 Activating mutations of EZH2, an epigenetic regulator, are present in approximately 20% o

238 modified the expression profiles of central epigenetic regulators of DNA methylation, histone modifi

239 Mutations in epigenetic regulators such as DNMT3A and TET2 confer an

240 roup (TrxG) of proteins is a large family of epigenetic regulators that form multiprotein complexes t

241 roscopy, we significantly expand the list of epigenetic regulators that impact nuclear morphology.

242 ms orchestrated by transcription factors and epigenetic regulators.

243 Interactions between genetic factors and epigenetic regulatory mechanisms may be crucial for asth

244 e emerging role of transcription factors and epigenetic remodelling in macrophages in the context of

245 ilencing Hub (HUSH) complex is necessary for epigenetic repression of LINE-1 elements.

246 suppressing breast cancer stem cells through epigenetic repression of stemness master transcription f

247 e CB(1) cannabinoid receptors, thus inducing epigenetic repression of transcriptional regulatory netw

248 sional genome reorganization, which leads to epigenetic reprogramming and derepression of development

249 chromatin accessibility profiling uncovering epigenetic reprogramming at >1400 sites in neurons after

250 Epigenetic reprogramming in Acute Myeloid Leukemia (AML)

251 Epigenetic reprogramming is involved in the response to

252 the long-term effects of EHS are mediated by epigenetic reprogramming is unknown.

253 It involves a profound transcriptional and epigenetic reprogramming of cells.

254 ngs decipher a proinflammatory metabolic and epigenetic reprogramming of macrophages in N-ERD.

255 ced at distant metastatic sites and mediates epigenetic reprogramming of metastatic tumor cells.

256 ram histone methylation during three crucial epigenetic reprogramming windows: maternal reprogramming

257 ing the mechanisms of hPGC specification and epigenetic reprogramming.

258 nd sensitize tumours to targeted therapy via epigenetic reprogramming.

259 our knowledge of the molecular, genetic and epigenetic requirements that underpin normal placentatio

260 also alter the brain's initial molecular and epigenetic response to cocaine.

261 Thus, B2/ALU SINEs may be classified as "epigenetic ribozymes" that function as transcriptional s

262 t, newly emerging shoots display an opposite epigenetic scenario associated with CcMADS19 repression,

263 tes that a block of H3K9 methylations in the epigenetic sequence determines the compaction state at a

264 NA methylation data and can also analyze any epigenetic signal with genomic coordinates.

265 Thus, the angiocrine-metabolic-epigenetic signaling axis specified by the endothelium i

266 integration into COMPASS and contributes to epigenetic signaling.

267 e learning, and network analysis to identify epigenetic signals that not only track with age, but als

268 nclusion of a spliced exon based on adjacent epigenetic signals, and we showed that distinct spatio-t

269 repression domains (BGRD) on chromatin as an epigenetic signature for oncogenes.

270 ul to better detect outlier-free genetic and epigenetic signatures in various complex diseases and th

271 y reveals distinct neuronal and non-neuronal epigenetic signatures, and identifies a locus in the pro

272 Using epigenetic signatures, we identified enhancers for each

273 stage, coinciding with the loss of promoter epigenetic silencing factors.

274 H3 lysine 27 (H3K27) methylation to mediate epigenetic silencing of target genes.

275 cumulation of alterations in the genetic and epigenetic spaces has been proposed as an explanation fo

276 nover to promote gene silencing and preserve epigenetic stability of heterochromatin.

277 Accurate estimation of the epigenetic state has vast medical and biological implica

278 he activity of transcription factors and the epigenetic state of chromatin.

279 Our data suggest that the epigenetic state of the viral genome is an important det

280 ce, stemness, differentiation potential, and epigenetic state to probe HSC function and population st

281 dent tagging system in mice to determine the epigenetic state, 3D genome architecture and transcripti

282 ryos induced oxidative stress, disturbed the epigenetic state, and caused ER stress, while melatonin

283 in opposing ways to maintain their preferred epigenetic state.

284 evels, is causal for diapause metabolism and epigenetic state.

285 lf-renewal ability by interfering with their epigenetic state.

286 Regression modeling of epigenetic states at cCREs and gene expression produced

287 and maintenance of transcriptionally silent epigenetic states or heterochromatin.

288 nnotation system, we identified and assigned epigenetic states simultaneously along chromosomes and a

289 ectedly rich relationships between inherited epigenetic states, transcription factor-DNA binding affi

290 of cells occupying alternate "on" and "off" epigenetic states.

291 f histone modification activities to promote epigenetic switching between opposing chromatin states.

292 Thus, epigenetic targeting agents are attractive immunomodulat

293 for the development and application of both epigenetic therapies and cancer immunotherapies, and com

294 rlying the synergy between immunotherapy and epigenetic therapies and detail current efforts to trans

295 These interactions make combined epigenetic therapy and immunotherapy an attractive appro

296 These findings show that combining an epigenetic therapy with a noncanonical WNT signaling pat

297 The epigenetic traits of cancer cells and of associated tumo

298 the ability of cells to generate and inherit epigenetic transcriptional states.

299 es, across all three generations, indicating epigenetic transfer of effects.

300 We compare genetic and epigenetic variation as well as expression profiles betw