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1 re utilized by chromatin modifiers to affect epigenetic modification.
2 tone H3K9 trimethylation and drive heritable epigenetic modification.
3 ed of cytosine, they are potential sites for epigenetic modification.
4 ity to BREX system defense is provided by an epigenetic modification.
5 -bias, and demonstrating direct detection of epigenetic modifications.
6 t govern the heritability and maintenance of epigenetic modifications.
7 y-life experiences influence behavior is via epigenetic modifications.
8 r-changing environment and the influences of epigenetic modifications.
9 proaches for intervention by targeting these epigenetic modifications.
10 synthesis of nucleotides and amino acids and epigenetic modifications.
11 the physiology and behavior of offspring via epigenetic modifications.
12 olve either mitochondrial dysfunction and/or epigenetic modifications.
13 ight, litter size, maternal cannibalism, and epigenetic modifications.
14 nd serves to coordinate glycolytic flux with epigenetic modifications.
15 tative analysis of 3D nuclear structures and epigenetic modifications.
16 and biology may be gained through studies of epigenetic modifications.
17 nal allele or maternal allele as a result of epigenetic modifications.
18 d affect gene expression in a similar way to epigenetic modifications.
19 gulates its transcriptional activity through epigenetic modifications.
20 ing is often associated with allele-specific epigenetic modifications.
21 egulation and obesity in adult offspring via epigenetic modifications.
22 to accurately detect structural variants or epigenetic modifications.
23 ip between the function of phytohormones and epigenetic modifications.
24 NA is essential to understanding the role of epigenetic modifications.
25 regulate sense transcription by induction of epigenetic modifications.
26 of lysines is one of the best characterized epigenetic modifications.
27 leads to downstream changes in TET1-mediated epigenetic modifications.
28 es and genes involved in neuroplasticity and epigenetic modifications.
29 ones as well as on the mechanisms regulating epigenetic modifications.
30 sion, labeling of specific genomic loci, and epigenetic modifications.
31 to subsequent generations through heritable epigenetic modifications.
32 some phytohormones have been shown to affect epigenetic modifications.
33 uracil is one of several recently discovered epigenetic modifications.
34 etic variations, transcriptomes, and certain epigenetic modifications.
35 downregulation resulting in decreased 5-hmC epigenetic modifications.
36 metric insight into the complex reactions of epigenetic modifications.
37 broblasts in fibrotic diseases might involve epigenetic modifications.
38 ay to understand the biological functions of epigenetic modifications.
39 novel gene networks regulated by particular epigenetic modifications.
40 possible interplay between the two types of epigenetic modifications.
41 ative 'damage' to DNA might be relabeled as 'epigenetic' modifications.
42 at obesity exaggerates hyperglycemia-induced epigenetic modifications, accelerating mitochondrial dam
45 sequence was used to examine how these four epigenetic modifications alter the thermal and pH stabil
51 s are intrinsically sensitive to genetic and epigenetic modifications and can therefore be significan
52 eginning to build causal links between these epigenetic modifications and changes in addiction-relate
53 However, the molecular basis for rhythmic epigenetic modifications and circadian regulation is poo
54 e exposure after weaning) induced changes to epigenetic modifications and CTCF binding at select regu
55 fests in decreased mutual information across epigenetic modifications and gene expression attributed
56 terations in gene expression, and that these epigenetic modifications and gene expression profiles ar
57 e authors discuss the expanding landscape of epigenetic modifications and highlight their importance
61 chanistic insight into the crosstalk between epigenetic modifications and post-translational modifica
62 le and BMI could be beneficial in regulating epigenetic modifications and preventing/retarding retino
63 pha protein leading into the IFI16-dependent epigenetic modifications and silencing of KSHV lytic gen
64 w summarizes our knowledge of opioid-induced epigenetic modifications and their consequential changes
65 genomic datasets enables in-depth studies of epigenetic modifications and their relationships with ch
66 not only transcription factors but also the epigenetic modifications and three-dimensional chromosom
67 in a mechanism that combines RNA silencing, epigenetic modification, and chromatin remodeling machin
70 analyses on special transcriptional factors, epigenetic modifications, and eQTLs demonstrated that EA
72 rted to alter global gene expression, induce epigenetic modifications, and interfere with complex reg
73 of the barrier topography, its modulation by epigenetic modifications, and their effects on Pol II nu
78 the beginning of mammalian life, and dynamic epigenetic modifications are essential for mammalian nor
84 ption factors promote cell identities, while epigenetic modifications are thought to contribute to ma
85 pact kidney graft survival, especially those epigenetic modifications associated with early transplan
86 ts demonstrate the potential malleability of epigenetic modifications associated with mercury exposur
89 CXCL4L1 expression was also controlled by epigenetic modifications at critical CpG islands, which
90 ks, manipulate chromatin topology and induce epigenetic modifications at multiple genes in the same c
91 elomere length-dependent gene regulation and epigenetic modifications at sites spread across the geno
92 proaches, did not establish causal roles for epigenetic modifications at specific genes because these
94 PRMT5) molecular complex that make important epigenetic modifications by methylating histone arginine
95 histones (in particular, histone H3), these epigenetic modifications can also repress viral gene exp
98 A growing body of evidence indicates that epigenetic modifications can provide efficient, dynamic,
99 compatibility, the prevalence of genetic and epigenetic modifications caused by exchanges between gra
101 transcription, replication, DNA repair, and epigenetic modification, chromatin forms the nexus of mo
102 non-muscle genes through affecting regional epigenetic modifications, chromatin accessibility and su
104 Although the majority of work examining how epigenetic modifications contribute to addiction has foc
106 xidize fatty acids to produce acetyl-CoA for epigenetic modifications critical to lymphangiogenesis.
108 the activity of selected clock components or epigenetic modifications, depending on the time delay be
109 r the complex patterns of mutually exclusive epigenetic modifications deposited at different alleles
110 be either enhanced or inhibited by specific epigenetic modifications deposited on histones (in parti
112 trations of a DNA-protein interaction and an epigenetic modification directly regulating E3 ubiquitin
113 f DNA and methylated DNA compared with other epigenetic modifications, DNA methylation is an ideal ma
114 how that H3K27me3 is a dynamic and important epigenetic modification during CD4 T cell activation and
115 tin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and
116 provides a novel framework for the timing of epigenetic modifications during the lifespan and transge
117 ing to transcription elongation, the role of epigenetic modifications during this critical transition
122 f binding 5-hydroxymethylcytosine (5hmC), an epigenetic modification generated by TET proteins, was p
123 ducers of DNA damage (group 2), effectors of epigenetic modification (group 3), anthracyclines (group
127 including pioneer factors, coregulators and epigenetic modifications have been identified as regulat
130 5-methylcytosine is the most studied DNA epigenetic modification, having been linked to diverse b
132 phenotypic variability in WS likely involves epigenetic modifications; however, the nature of these e
133 cury exposure and DNA hydroxymethylation, an epigenetic modification important for tissue differentia
135 he cardiomyocyte and suggest a role for this epigenetic modification in heart development and disease
137 ks metabolic adaptation to transgenerational epigenetic modification in response to acute periods of
138 animal models have begun to reveal aberrant epigenetic modifications in brain and the periphery link
139 understanding biochemical characteristics of epigenetic modifications in cancer, the in-situ higher-o
141 e is a versatile tool to study the effect of epigenetic modifications in differentiation/development,
143 hildhood asthma begins at birth and involves epigenetic modifications in immunoregulatory and proinfl
144 st inflammatory response is characterized by epigenetic modifications in key regulatory genes, includ
145 ymethylcytosine (5hmC) are the two major DNA epigenetic modifications in mammalian genomes and play c
149 ible for their damage as well as the role of epigenetic modifications in mitochondrial homeostasis sh
150 These results reveal a critical role for epigenetic modifications in modulating brain functions,
151 aterial systems: the localization of histone epigenetic modifications in neural stem cells cultured o
152 o CCC, but little is known about the role of epigenetic modifications in pathological gene expression
154 ghlighted the role of activating factors and epigenetic modifications in regulating replication initi
157 provide evidence on the associations between epigenetic modifications-in our case, CpG methylation-an
158 their relationship with parallel rhythms of epigenetic modification including histone acetylation, a
160 ealed a SLUG-mediated temporal regulation of epigenetic modifications, including accumulation of H3K2
161 tudy, we found that dysbiosis in vivo led to epigenetic modifications, including acetylation of histo
165 lar metabolites and nutrition levels control epigenetic modifications, including histone methylation.
166 the latest research progress on mRNA and DNA epigenetic modifications, including the detection, dynam
168 reared salmon provides evidence for parallel epigenetic modifications induced by hatchery rearing in
174 hronic cocaine and found that locus-specific epigenetic modification is essential for FosB induction
175 Our model indicates that the spreading of epigenetic modifications is sensitive to heterogeneity i
176 f cytosine residues in DNA, the best studied epigenetic modification, is associated with gene transcr
177 and 5-Hydroxymethylcytosine in DNA are major epigenetic modifications known to significantly alter ma
182 nucleus accumbens core, likely mediated via epigenetic modifications, may render individuals more su
186 her this signaling involves STAT activation, epigenetic modification of chromatin, or both mechanisms
191 e receptor promoter regions, suggesting that epigenetic modification of germ cell DNA may mediate tra
192 n of gene expression, including via targeted epigenetic modification of regulatory elements in a broa
193 in Friedreich's ataxia (FRDA) are linked to epigenetic modification of the FXN locus caused by the d
197 e, Bcl-xL exerts metastatic function through epigenetic modification of the TGFbeta promoter to incre
198 J (beta-d-glucosyl-hydroxymethyluracil), an epigenetic modification of thymidine (T) confined to pat
199 ssion of CD73 and folate receptor 4, and the epigenetic modification of Treg cell signature genes-and
200 ncy and carcinogenesis involve the selective epigenetic modification of viral and cellular genes.
202 r, recent advances have begun to reveal that epigenetic modifications of chromatin structure also hav
206 f adipose tissue and skeletal muscle precede epigenetic modifications of genes involved in muscle ene
210 research of the newly identified and unknown epigenetic modifications of mRNA and DNA in plants.
213 bundant chromatin-associated proteins and by epigenetic modifications of the C-terminal tail of linke
214 e proinflammatory cytokines, and exhibit the epigenetic modifications of the FOXP3 gene enhancer CNS2
219 ne expression programs are tightly linked to epigenetic modifications on DNA and histone proteins.
224 ses to pregnancy, altered maternal behavior, epigenetic modifications, or a combination of mechanisms
225 in a strong biological hypothesis related to epigenetic modifications, oxidative stress, and inflamma
226 Recent clinical studies have suggested that epigenetic modification, particularly methylation of gen
227 ndings corroborate the emerging concept that epigenetic modifications play a role in the development
230 e intricate, diverse, and dynamic roles that epigenetic modifications play in plant-nematode interact
231 mA) has recently been found as an essential epigenetic modification, playing its roles in a variety
236 f factors beyond the DNA sequence, including epigenetic modifications, RNA transcripts, proteins, and
237 exposure to environmental agents), but some epigenetic modifications seem to persist, even for decad
240 comitrella patens, PpMACRO2, is important in epigenetic modification, stem cell function, cell reprog
246 s less predictive for enhancer activity than epigenetic modifications such as H3K4me1 or the accessib
247 drial metabolites are primary precursors for epigenetic modifications (such as methyl and acetyl), wh
248 ong-term persistence of specific patterns of epigenetic modifications, such as DNA methylation, we pr
249 terochromatin and associated with repressive epigenetic modifications, such as H3K9me3 and C5 cytosin
250 promoter, concomitant with agonist-specific epigenetic modifications targeting histone H4 lysine ace
255 tion of histone lysine residues serves as an epigenetic modification that directly stimulates gene tr
258 a global decrease in histone acetylation, an epigenetic modification that is associated with gene act
260 e the trimethylation of H3K27 (H3K27me3), an epigenetic modification that marks transcriptional repre
263 he SATB2-AS1-SATB2-Snail axis is involved in epigenetic modification that regulates colorectal carcin
264 on at the 5-position of cytosine (5mC) is an epigenetic modification that regulates gene expression a
267 d into adulthood of animals through specific epigenetic modifications that allow for selective gene e
268 response to disuse is accompanied by dynamic epigenetic modifications that are associated with altera
269 odifications, S-nitrosation, and genome-wide epigenetic modifications that can have both tumor-promot
270 scade of activated transcription factors and epigenetic modifications that drive gene transcription r
271 onic inflammation induces transcriptomic and epigenetic modifications that imparts a persistent catab
272 sensory experience as well as differences in epigenetic modifications that may emerge in HC and LC vo
274 ng cells and provide preliminary evidence of epigenetic modifications that might translate to pulmona
275 ng of transcription factors and accompanying epigenetic modifications that occur during osteogenic an
276 to illuminate the emerging understanding of epigenetic modifications that regulate both adaptive and
277 adaptive and maladaptive consequences of the epigenetic modifications that result from complex enviro
278 this are alterations at the chromatin level (epigenetic modifications) that regulate constitutive and
279 ays involved in the fibrosis and may recover epigenetic modification; therefore, it could possibly be
280 ymethylcytosine (5hmc) is a newly identified epigenetic modification thought to be regulated by the T
281 hese data suggest that dietary modulation of epigenetic modifications through elevation of beta-hydro
282 ge of any incoming DNA that lacks a specific epigenetic modification, through a system known as restr
286 evious results, diet-induced obesity induces epigenetic modifications to chromatin in mouse liver.
287 he identification and discrimination of four epigenetic modifications to cytosine in the proposed act
289 module is governed by dynamic alterations in epigenetic modifications to promoters and binding by Oct
290 vel evidence supporting a potential role for epigenetic modifications to the genome in D. magna envir
294 al defense, epithelial barrier function, and epigenetic modification were observed between the flavor
297 al stem cells are susceptible to genetic and epigenetic modifications, which facilitate oncogenic tra
298 onary mechanisms, such as gene mutations and epigenetic modifications, which is manifested in the for
300 -/-) CD4(+) T cells do not obtain permissive epigenetic modifications within the Th2 locus, which wer