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1 ng that the row type in barley is determined epigenetically.
2 pression in premalignant cells are regulated epigenetically.
3 their host, which responds by silencing them epigenetically.
4 cruitment of a novel RARbeta-TET2 complex to epigenetically activate a specific cohort of gene target
6 2 to recruit histone-remodeling factors that epigenetically activate transcriptionally silent rDNA.
7 LATION 1 (DDM1), giving rise to 21- to 22-nt epigenetically activated siRNA (easiRNA) that depend on
9 red for the accumulation of 21/22-nucleotide epigenetically activated siRNAs, which likely silence TE
10 RNAs could help to tighten the expression of epigenetically activated TEs and genes using the methyla
11 omethylation of H3K4me3, thereby suppressing epigenetically-activated oncogenic pathways in melanoma.
13 d by hypoxia-inducible factor 1 (HIF-1) that epigenetically activates pluripotency factor gene transc
14 mation of the chromatin modifier PRC2 and by epigenetically activating NOTCH signals in human colorec
16 and survival of human glioblastoma cells by epigenetically activating the transcription of Wnt targe
17 RMT5 promotes prostate cancer cell growth by epigenetically activating transcription of the androgen
18 ial and survival of human colorectal CSCs by epigenetically activating Wnt target gene transcription.
26 and the molecular heterogeneity among 1,256 epigenetically analysed cases, and identify subgroup-spe
28 odifications to identify multiple classes of epigenetically and functionally distinct cis-regulatory
29 histone H3 variant CENP-A marks centromeres epigenetically and is essential for mitotic fidelity.
31 in a rare subset of "2C-like" cells that are epigenetically and transcriptionally similar to the two-
32 ars) become more similar to each other, both epigenetically and transcriptionally, compared with youn
33 etochore is assembled in mitosis, is defined epigenetically, and its location must be remembered with
34 strate that cellular plasticity is regulated epigenetically, and that mesenchymal-like tumor cell pop
35 cells that are inconsistent with classical, epigenetically based theories of disease progression, su
36 CD4 T cells proliferate rapidly and remodel epigenetically before exiting the cell cycle and engagin
38 modulated through transcription factors, or epigenetically by aberrant histone acetylation or DNA me
39 timal FAS expression, FAS can be upregulated epigenetically by derepression of the FAS promoter using
40 evidence that miR-34a expression is silenced epigenetically by EZH2 and DNA methylation, which promot
41 hed for repetitive sequences, and is defined epigenetically by methylation of histone H3 at lysine 9
42 nal programme of vertebrate cells is carried epigenetically by post-translational modifications of hi
43 In most eukaryotes, centromeres are defined epigenetically by presence of the histone H3 variant CEN
44 ed phenomena such as genome editing mediated epigenetically by RNA, as well differential nuclear impo
45 t nestin regulation is negatively controlled epigenetically by TET2 via 5-hmC binding at the 3' untra
46 attachment during cell division, are marked epigenetically by the centromere-specific histone H3 var
50 were inundated by three variant progenitors epigenetically committed to distinct metaplastic lesions
51 e transforming growth factor beta (TGF-beta) epigenetically conditions resting naive CD8(+) T cells a
52 cal individuals, and this is associated with epigenetically conferred phenotypic differences, environ
53 re, we investigated how the lncRNA NEAT1 may epigenetically contribute to hippocampus-dependent, long
54 different stages of LUAD progression and can epigenetically control diverse transcriptional programs
56 erning gene expression, we employed a unique epigenetically controlled and highly tissue-specific gre
57 ly clear that neurobehavioral phenotypes are epigenetically controlled by noncoding RNAs (ncRNAs).
60 ARID5B expression, possibly regulated by an epigenetically controlled enhancer, promotes atheroscler
61 signaling pathways or neuroinflammation are epigenetically controlled in the fibrotic disorders invo
71 ger et al. elegantly demonstrates that three epigenetically defined, and functionally disparate, chro
73 lung maturation in the prenatal period were epigenetically deregulated and could be linked with whee
76 ation prevents adipogenic gene expression by epigenetically deregulating long-range enhancers of the
77 lement to mediate chromosome segregation, is epigenetically determined by CENH3-containing nucleosome
80 centromere-specific histone H3 variant that epigenetically determines centromere identity, but how C
81 e heterogametic systems, the X Chromosome is epigenetically differentiated between males and females,
82 goes a sharp transition between a stretched, epigenetically disordered, state and a crumpled, epigene
85 y incorporated by sister chromatids, and how epigenetically distinct sister chromatids are specifical
86 provide the cellular basis for partitioning epigenetically distinct sister chromatids during stem ce
87 te that over half of the cases have multiple epigenetically distinct subclones and determine the prim
90 utes 40-50% of all AML cases and is the most epigenetically diverse AML subtype with pronounced chang
94 l, perinatal nicotine exposure results in an epigenetically driven multi- and trans-generationally tr
95 utations, PFA ependymomas are proposed to be epigenetically driven tumors for which model systems are
97 preferentially reduced growth in a subset of epigenetically dysregulated colon cancers characterized
98 data demonstrate that the Foxp3 locus can be epigenetically edited ex vivo to generate stable therape
99 ) and studied whether the Foxp3 locus can be epigenetically edited ex vivo to produce stable therapeu
100 ted into diabetic, immunodeficient mice, the epigenetically edited islets show increased beta cell re
101 haustion or dysfunction(1), is manifested by epigenetically enforced changes in gene regulation that
103 previously unrecognized subsets of clonally, epigenetically, functionally, phenotypically and transcr
104 R, which induces a reversible glycolytic and epigenetically H4K16Ac-negative, diapause-like state.
107 methylation in the Ppargc1a promoter, which epigenetically impairs BAT thermogenesis and energy expe
108 and perturbs the expression of a network of epigenetically imprinted genes that have been implicated
109 LS), which form the lining of the joint, are epigenetically imprinted with an aggressive phenotype in
113 lement generates maternal allele identity by epigenetically inactivating the PWS-SRO in oocytes so th
114 , the TEtra factors occupy multiple sites in epigenetically inactive placental genes and in OCT4 Func
117 chromatin-level silencing that in plants is epigenetically inherited from generation to generation.
119 tone H3 lysine 9 methylation (H3K9me) can be epigenetically inherited independently of underlying DNA
124 The present study demonstrates that NTRK2 is epigenetically linked to memory functions in nontraumati
125 dings demonstrate that FGF21-JMJD3 signaling epigenetically links nutrient deprivation with hepatic a
128 S complex monomethylates H3K4 that serves to epigenetically mark transcriptional enhancers to drive p
129 c 3-kb region within LILRB1 intron 1 that is epigenetically marked as an active enhancer in human lym
133 inhibitor-refractory tumors, which supports epigenetically mediated reversal of treatment resistance
134 underpins how discrete polyphenic traits in epigenetically metastable conditions can contribute to a
135 s been related to 5-methylcytosine (5mC), an epigenetically modified base which resides in CpGs and p
137 tral pH were significantly more likely to be epigenetically modified than traditional acidic i-motif
138 d that parts of these putative enhancers are epigenetically modified to a more open chromatin state u
140 ssociated with mitochondrial homeostasis are epigenetically modified, further contributing to the mit
143 eactive oxygen and nitrogen species that can epigenetically modulate DNA methylation, histone deacety
144 Furthermore, microRNA-200a expression is epigenetically modulated by both DNA methylation at the
145 al, and blood epigenetic transcriptomes; and epigenetically modulates neuronal plasticity and stress-
147 indicating that cardiac form and function is epigenetically optimized to accommodate vortex ring form
148 and developmental cues, and then maintained epigenetically over many cell divisions, remains poor.
149 ors but can also regulate gene expression by epigenetically phosphorylating histone H3 on tyrosine 41
151 The present study aimed to test whether MO epigenetically predisposes adipocyte progenitors in the
153 s associated with each germ layer are either epigenetically primed or remodelled before cell-fate dec
155 l regulators of animal development gained an epigenetically privileged state in germ cells, manifeste
157 man lung epithelial cells, some of which are epigenetically programmed at the level of miRNA regulati
160 ryptic regulatory elements within TEs can be epigenetically reactivated in cancer to influence oncoge
162 Tet3 serves as a synaptic activity sensor to epigenetically regulate fundamental properties and meta-
163 co-activator or co-repressor complexes that epigenetically regulate gene expression by post-translat
164 mechanism of RARbeta via miR-22 induction to epigenetically regulate itself and NUR77, providing a pr
168 n the transcriptome studies to date are also epigenetically regulated at the DNA level after acute, c
169 d also indicate that they are differentially epigenetically regulated beyond X chromosome imprinting.
170 genes involved in synaptic communication are epigenetically regulated by H3K9me1 in dependent rats.
172 echanism by which drug-induced senescence is epigenetically regulated by macroH2A1 and DNA methylatio
176 ppa physiology, whereby this receptor may be epigenetically regulated by stressful experiences, in pa
181 arameters is a powerful tool for identifying epigenetically regulated drivers of HCC and elucidating
182 nes within virions but are chromatinized and epigenetically regulated following delivery to the host
183 epressing the FOXO/c-Myc axis, unraveling an epigenetically regulated FOXO/c-Myc axis as a potential
186 rable number of HOX genes are differentially epigenetically regulated in aged human skeletal muscle a
187 gene expression changes were PYGM, which was epigenetically regulated in both groups, and ANGPTL4, wh
190 Known imprinted regions are enriched among epigenetically regulated loci, but we also observe sever
191 cing we demonstrate that miR-663 promoter is epigenetically regulated not only by genetic but also by
192 These findings establish VAV1 as a critical epigenetically regulated oncogene with a key role in MBS
193 ternative splicing (AS) is a genetically and epigenetically regulated pre-mRNA processing to increase
195 In this study, we identified miR-192 as an epigenetically regulated suppressor gene with predictive
203 rsely regulated to MuRF1/MAFbx; (ii) UBR5 is epigenetically regulated; and (iii) UBR5 is elevated at
205 These results strongly argue that O-GlcNAc epigenetically regulates MYBL1, functioning similarly to
206 tor and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of co
207 interplay between HMGNs and H1 in chromatin epigenetically regulates the expression of OLIG1&2, ther
208 n important role for the Tet2-Foxo3a axis in epigenetically regulating critical genes in aNSCs during
209 We aimed at investigating EZH2's role in epigenetically regulating Wnt/beta-catenin signaling fol
210 E3A was sufficient to stabilize SIRT6 and to epigenetically repress ANXA2, a key mediator of UBE3A on
212 sor gene fructose-1,6-bisphosphatase (FBP1), epigenetically repressed in HCC, was restored by CM-272.
214 repeats of the ERV9/LTR12 family, which are epigenetically repressed in virtually all normal cells.
215 mpromise that the maternal allele has become epigenetically repressed rather than genetically deleted
216 T-116 colon cancer cells, in which hMATE1 is epigenetically repressed, can be sensitized to compound
219 ns play vital roles in plant development via epigenetically repressing the transcription of target ge
220 overweight around the time of conception can epigenetically reprogram father's germ-line and modulate
223 mutation fosters malignant transformation by epigenetically reprograming B cells to form an aberrant
225 Major" workers defend the colony, but can be epigenetically reprogrammed to forage for food analogous
227 We report that parental metabolic syndrome epigenetically reprograms members of the TGF-beta family
228 -mediated induction of nuclear p50 NF-kappaB epigenetically reprograms the response of monocytic cell
229 etylase inhibitors have been demonstrated to epigenetically reverse the low major histocompatibility
231 ecent findings indicate little plasticity of epigenetically scripted hematopoietic stem/progenitors.
232 ogether, these results suggest that UPEC can epigenetically silence BIM expression, a molecular switc
233 ctions with Polycomb repressive complex 2 to epigenetically silence FLOWERING LOCUS C (FLC) during ve
234 echanistically, BIM expression appears to be epigenetically silenced by a decrease in histone 4 acety
235 t in eukaryotic genomes which are in general epigenetically silenced by DNA methylation and/or histon
237 emethylation treatment showed that NR4A3 was epigenetically silenced by promoter DNA methylation in S
239 CA and our findings demonstrate that AOX1 is epigenetically silenced during BLCA progression by the m
241 e progenitor genes and cell cycle genes were epigenetically silenced during retinogenesis, the most d
242 erferes with this polymerization, but HbF is epigenetically silenced from infancy onward by DNA methy
246 in elucidating genes and microRNAs that are epigenetically silenced in lung cancer and highlights ho
250 The paternal UBE3A/Ube3a allele becomes epigenetically silenced in most neurons during postnatal
253 as-GTPase-activating protein, was frequently epigenetically silenced in RCC, and DAB2IP loss was corr
255 ter regulator of sexual development, from an epigenetically silenced state during asexual replication
256 son theory of aging, which hypothesizes that epigenetically silenced TEs become deleteriously activat
257 ion that threatens genome integrity, TEs are epigenetically silenced through several pathways, and th
258 y reverses DNA hypermethylation, reactivates epigenetically silenced tumor suppressor genes (TSGs), a
259 of MOAP-1) is one of the earliest detectable epigenetically silenced tumor suppressor proteins in can
260 se findings demonstrate that GPC5 is a novel epigenetically silenced tumor suppressor, which inhibits
262 aled that ZFP36L1 was significantly mutated, epigenetically silenced, and downregulated in a variety
264 Taken together, aberrant JAK/STAT3 signaling epigenetically silences a potential tumor suppressor, NR
266 OX6 suppresses epidermal differentiation and epigenetically silences critical genes involved in kerat
267 udy, we investigated the role of EZH2, which epigenetically silences gene expression by histone methy
268 e the miR-34a promoter simultaneously, hence epigenetically silencing miR-34a expression independent
272 that control chromosome segregation, and are epigenetically specified by the presence of the CENP-A c
274 depend on the histone H3 variant, CENP-A, to epigenetically specify the location of the centromere-th
275 indicate that the food-derived compound SFN epigenetically stimulates osteoblast activity and dimini
276 ants quantitatively sense long-term cold and epigenetically store this cold-exposure information to r
278 Using this strategy to screen a library of epigenetically targeted compounds, we identified inhibit
279 euroblastoma with TERT overexpression and an epigenetically targeted novel therapeutic strategy.
280 L31 locus as an example, we demonstrate that epigenetically targeted sequences function as distantly-
281 pproach, we applied this method to screen an epigenetically targeted small molecule library by evalua
283 t combining the activity of VPA, to modulate epigenetically the cellular acetylome, with chloroquine,
286 which immunological memory state is encoded epigenetically, through poising and transcriptional memo
289 uding clinically relevant genes dysregulated epigenetically, transcriptionally, or post-transcription
290 e contains several prion elements, which are epigenetically transmitted as self-perpetuating protein
291 The present results uncover a spectrum of epigenetically unique adaptive NK cell subsets that dive
294 lear receptor farnesoid X receptor (FXR) and epigenetically up-regulates FXR targets important for th
296 onocytes, we showed that FABP4 expression is epigenetically upregulated in diabetic wound macrophages
298 E3 ubiquitin ligase, named UBR5, is altered epigenetically (via DNA methylation) after human skeleta
299 oleraceum and Zea mays, although specifying epigenetically weaker centromeres that result in genome
300 ternal chromosome are present, but repressed epigenetically, which provides an opportunity for the us