ライフサイエンスコーパス: epigenetics

1 ientists in advancing the field of synthetic epigenetics.

2 pathways and molecular mechanisms including epigenetics.

3 ular choreography is central to the field of epigenetics.

4 rtunities to explore in translational cancer epigenetics.

5 challenge for current and future research in epigenetics.

6 iscovered to the present day of big data and epigenetics.

7 suggest a connection between metabolism and epigenetics.

8 llmarks associated with protein turnover and epigenetics.

9 via alterations of local gene expression or epigenetics.

10 ergence of a novel mechanism coupling AS and epigenetics.

11 Bisulfite sequencing is a key methodology in epigenetics.

12 kely influence the broader research field of epigenetics.

13 field of biology referred to as the study of epigenetics.

14 one modification events studied by classical epigenetics.

15 terpret results in the fast growing field of epigenetics.

16 itable differences that could be mediated by epigenetics.

17 tting-edge measures such as metabolomics and epigenetics.

18 elopmental plasticity and may be mediated by epigenetics.

19 on the histones, is of central importance to epigenetics.

20 ging, but not yet fully elucidated, field of epigenetics.

21 link between the primed state in plants and epigenetics.

22 cium tetraurelia, a long-standing problem in epigenetics.

23 sion, and metastasis; energy metabolism; and epigenetics.

24 remodeling of nuclear factors that influence epigenetics.

25 rds developmental and environmental cues, is epigenetics.

26 on health could potentially be mediated via epigenetics.

27 een a major unresolved issue in the field of epigenetics.

28 enerated remains a major unsolved problem in epigenetics.

29 ial far-reaching implications for behavioral epigenetics.

30 ology, neuroplasticity, transcriptomics, and epigenetics.

31 k between Isl1 complexes and global cellular epigenetics.

32 es complex and link the species problem with epigenetics.

33 become one of the most researched topics in epigenetics.

34 s, telomere length homeostasis, and telosome epigenetics.

35 cDNA biology with modern cancer genomics and epigenetics.

36 rmation coded by the sequence, process named epigenetics.

37 H3K27ac indicating a possible involvement of epigenetics.

38 or understanding the ecological relevance of epigenetics.

39 ckground, we hypothesize that differences in epigenetics account for the striking functional differen

40 xamples in which chromatin modifications and epigenetics affect important plant processes.

41 The importance of genetic susceptibility, epigenetics, aging, and the modern-day environment are h

42 e against generically equating chromatin and epigenetics; although many examples of epigenetics invol

43 These methods will open up epigenetics analyses to the proteomics community who do

44 t disease and supports a key contribution of epigenetics and a prenatal cell of origin during a criti

45 loiting the complex interplay between cancer epigenetics and cancer immunology to develop treatment r

46 These findings shed light on the epigenetics and cellular origins of lineage-specific lun

47 providing new insights into the link between epigenetics and developmental patterning.

48 omatin plasticity, cell differentiation, and epigenetics and discusses current progress and future pe

49 provide an overview of the current state of epigenetics and epigenetic therapy in AML and will descr

50 Here, we highlight the emerging role of epigenetics and epigenomics in DKD and the translational

51 nd macromolecules such as starch and lipids, epigenetics and epigenomics, genome-wide association stu

52 Epigenetics and experiences of societal inequality (allo

53 Neuronal analyses such as transcriptomics, epigenetics and genome-wide association studies must be

54 study provides a link between Mtb infection, epigenetics and host immune response, which can be explo

55 the effect of various chemicals on germline epigenetics and how paternal exposure may impact the hea

56 cs is defined in opposition to developmental epigenetics and implies an absence of resetting of epige

57 tone deacetylases (HDACs) are key enzymes in epigenetics and important drug targets in cancer biology

58 thylation on histones is a central player in epigenetics and in gene activation and repression.

59 e level of not only gene expression but also epigenetics and inter-individual variation.

60 y proliferation state, signalling crosstalk, epigenetics and metabolism, and propose an update on the

61 s considered a novel regulatory mechanism in epigenetics and metabolism.

62 quantify links between tumour metabolism and epigenetics and outline clinical implications.

63 ptome, and also emphasises the importance of epigenetics and post-translational modifications in long

64 Despite growing evidence associating epigenetics and psychiatric disorders, it is unclear how

65 telen on PLN genetics, Folkert Asselbergs on epigenetics and Rudolf de Boer on clinical trials.

66 e moderately supports an association between epigenetics and schizophrenia and other psychotic disord

67 ting the lack of standardized definitions of epigenetics and the limited empirical support for potent

68 y and critical periods of brain development; epigenetics and the molecular underpinnings of biologica

69 icroenvironment has a broad impact in cancer epigenetics and therapeutics.

70 s, with dynamic data on chromatin structure, epigenetics and transcription factor binding.

71 Metabolism has been shown to integrate with epigenetics and transcription to modulate cell fate and

72 rive continued discovery at the interface of epigenetics and ubiquitin signaling.

73 erial choline metabolism on host metabolism, epigenetics, and behavior.

74 f their roles in transcriptional regulation, epigenetics, and cancer.

75 Genetics, epigenetics, and environment may together affect the sus

76 tigate the effect of genetic predisposition, epigenetics, and environmental exposures, avoiding pitfa

77 specific variation is caused by seasonality, epigenetics, and external environmental conditions.

78 sregulated circuits, memory reconsolidation, epigenetics, and genetic factors.

79 scientists and inspired the age of genetics, epigenetics, and genomics.

80 ration are necessary for cell proliferation, epigenetics, and HIF-1 activation.

81 Epigenetics, and in particular DNA methylation marks, ha

82 Furthermore, we show that diet, epigenetics, and microbiota are key elements in this met

83 ulation, and the structure of gene networks, epigenetics, and novel genes.

84 bolism, the HPA axis, neurogenesis and BDNF, epigenetics, and obesity.

85 Many cancers, including STS, contain altered epigenetics, and our findings define an epigenetic mecha

86 erosis: dominance, overdominance, epistasis, epigenetics, and protein metabolite changes.

87 papers in the fields of chromatin structure, epigenetics, and regulation of transcription in eukaryot

88 They describe how genetics, epigenetics, and the 3D genome architecture are coordina

89 (cell cycle regulation, DNA damage response, epigenetics, and transcription factors) to identify addi

90 es that aging exerts a profound influence on epigenetics, and vice versa.

91 affinity, and they performed well in common epigenetics applications.

92 e and cannabis products but impacts on sperm epigenetics are poorly characterized.

93 and areas of opportunity that discoveries in epigenetics are providing to the discipline of neuroscie

94 Human studies in the area of epigenetics are sorely lacking and should be a priority

95 Epigenetics are strongly implicated in initiation and pr

96 Epigenetics are the heritable changes in gene expression

97 We conclude that IUGR disrupts developmental epigenetics around distal GHREs on the rat hepatic IGF-1

98 n living systems that has been implicated in epigenetics as well as in the pathologies of various can

99 re recent translational research programs in epigenetics as well as the challenges inherent in the in

100 rmation independent of the DNA sequence, the epigenetics, as well as gene transcription are profoundl

101 Understanding the epigenetics associated with escape from X chromosome ina

102 hizophrenia and other psychotic disorders to epigenetics, based on PubMed and Web of Science database

103 provides the first proof of principle for an epigenetics-based therapy for PWS.

104 polymorphism poses an intriguing problem in epigenetics because it requires the unequal treatment of

105 of RNA-binding proteins can drive a form of epigenetics beyond the chromosome, instilling adaptive g

106 plicates regulation involving metabolism and epigenetics, beyond EMT driven by injury and repair in c

107 In addition, epigenetics blossomed with new insights about gene modif

108 t oxygenases are essential regulators of RNA epigenetics by serving as erasers of one-carbon marks on

109 icity and highlight how patient genetics and epigenetics can facilitate researchers and clinicians in

110 use of the terms chromatin modifications and epigenetics can help separate the biochemical mechanisms

111 There is increasing evidence that epigenetics can play a key role in the etiology of disea

112 regulators (CRs), which are indispensable in epigenetics, can mediate HMs to adjust chromatin structu

113 ns on several topics including: genetics and epigenetics; cancer origin and evolution; microenvironme

114 hrough complex effects on genetic stability, epigenetics, cellular metabolism, proliferation, and sur

115 There is continued interest in the plant epigenetics community in trying to understand the broade

116 e CR Cistrome is a valuable resource for the epigenetics community.

117 Epigenetics comprises the umbrella of biochemical reacti

118 We conclude by discussing epigenetics, conceptual implications within an evolution

119 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in

120 Within the Pregnancy And Childhood Epigenetics consortium, we performed epigenome-wide meta

121 These findings indicate that epigenetics contributes substantially to variation in pl

122 It is hypothesized that epigenetics contributes to plant phenotypic plasticity b

123 Evidence from epigenetics could lead to ways to detect, prevent, and r

124 ll type profiles, a majority of genomics and epigenetics data relies on the "reference-free deconvolu

125 Epigenetics describes processes that modify gene express

126 ll also highlight recent successes in cancer epigenetics drug discovery and consider important factor

127 cial insects are promising model systems for epigenetics due to their immense morphological and behav

128 se connection between signaling pathways and epigenetics during myodifferentiation in vitro.

129 ed the Workshop on Mitochondria, Energetics, Epigenetics, Environment, and DNA Damage Response on 25-

130 Complex interaction between genetics, epigenetics, environment, and nutrition affect the physi

131 The field of epigenetics explores changes in DNA structure that influ

132 tabolic targets, including those involved in epigenetics, Fe-S biogenesis, and glycine biology, for d

133 M) signatures remains a daunting task in the epigenetics field.

134 techniques remains a major challenge in the epigenetics field.

135 also deficient along with other biologic and epigenetics findings in the tumor microenvironment, conf

136 eview, we briefly outline some principles of epigenetics, focusing on highlighting important consider

137 Understanding the significance of epigenetics for plant ecology requires increased transfe

138 th respect to the translational relevance of epigenetics for the study of psychopathology and to cons

139 These observations suggest a broader role in epigenetics for these DNA repair proteins.

140 al signals have transformed our knowledge of epigenetics from a collection of curious biological phen

141 a personal perspective on the development of epigenetics, from its historical origins to what we defi

142 A report on the Plant Epigenetics: From Genotype to Phenotype Keystone Symposi

143 advances highlighting the interplay between epigenetics, genetics, and cell-to-cell signaling in can

144 the immunophenotype, biological properties, epigenetics, genetics, and clinical associations of huma

145 information is relevant to gene regulation, epigenetics, genome-wide association studies, evolutiona

146 of genetics, recent work (e.g. in genomics, epigenetics, genomic plasticity) obliges us to criticall

147 Epigenetics has an important role for the success of foo

148 Epigenetics has been associated with metabolic memory in

149 Epigenetics has been discussed as a potential factor inf

150 Certain PTMs' contribution to epigenetics has been extensively expounded; yet more eff

151 As a newly emerged research area, RNA epigenetics has drawn increasing attention recently for

152 The field of epigenetics has exploded in the last two decades, with i

153 Although epigenetics has received significant attention in the fi

154 The past decade of discovery in cancer epigenetics has revealed a number of similarities betwee

155 The field described as 'epigenetics' has captured the imagination of scientists

156 ics, lymphocytic mitochondrial outcomes, and epigenetics (histone H3 Lys-4 trimethylation and 5-methy

157 sist latently for years by manipulating host epigenetics; however, its molecular essence remains undi

158 te improved measurements of host (genomics), epigenetics, identification of agents (metabolomics, pro

159 t research on how chromatin organization and epigenetics impact regulation of gene expression.

160 ts to identify changes in paternal germ cell epigenetics in association with offspring disease risk,

161 for investigating the roles of genetics and epigenetics in cancer.

162 To study epigenetics in clear-cell ovarian cancer, fresh frozen t

163 s and academics on driver gene mutations and epigenetics in colorectal cancer.

164 ion and are key to understanding the role of epigenetics in complex diseases.

165 ssion in early sepsis, suggesting a role for epigenetics in coordinating the response to infection.

166 new avenues for using the full potential of epigenetics in crop improvement.

167 The field of epigenetics in eating disorders remains in its infancy.

168 been some progress in revealing the role of epigenetics in ecological processes, studies with non-mo

169 be recalibrated to improve understanding of epigenetics in hard-to-access tissues (e.g. atrium) and

170 nique opportunity to learn about the role of epigenetics in health and disease.

171 tic risk, and point to the potential role of epigenetics in mediating exposure effects on transcripti

172 veral studies that have revealed the role of epigenetics in multigenerational transmission of develop

173 marize our knowledge about transgenerational epigenetics in plants, which entails heritable changes i

174 d DNA from Eschericia coli, phosphorothioate epigenetics in Salmonella enterica Cerro 87, and oxidati

175 ecent research suggests an important role of epigenetics in shaping and maintaining cell identity in

176 nd clinical diagnosis may suggest a role for epigenetics in T1D pathogenesis; however, functional val

177 olism (cellular and whole body), the role of epigenetics in the developing prenatal and postnatal bra

178 gs define a crucial role of deregulated 5hmC epigenetics in the events leading to AD neurodegeneratio

179 Herein, the evidence implicating epigenetics in the pathogenesis of SSc is discussed with

180 and the role of environmental factors and/or epigenetics in the pathophysiology of CAKUT.

181 ur understanding of the role of genetics and epigenetics in this common disease.

182 The contribution of epigenetics in this process remains unknown.

183 Current knowledge about the role of epigenetics in type 2 diabetes (T2D) remains limited.

184 To better understand the role of epigenetics in WS phenotypes, we integrated DNA methylat

185 ystems-level approach highlights the role of epigenetics in WS, and provides a possible explanation f

186 ndividual regulatory process that constitute epigenetics, including DNA methylation, histone modifica

187 e study of methylation-mediated signaling in epigenetics, inflammation and beyond.

188 her development of strategies to incorporate epigenetics into breeding.

189 he challenges inherent in the integration of epigenetics into developmental and clinical psychology.

190 Integrating epigenetics into systems biology may critically enhance

191 n and epigenetics; although many examples of epigenetics involve chromatin changes, those chromatin c

192 ries, we suggest here a framework for cancer epigenetics involving three types of genes: 'epigenetic

193 Therefore, epigenetics is a key area of clinical investigation in d

194 Epigenetics is a suggested link between exposures and he

195 Epigenetics is a term that encompasses a variety of regu

196 Epigenetics is currently the focus of intense research i

197 Transgenerational epigenetics is defined in opposition to developmental ep

198 prisingly, it is also becoming apparent that epigenetics is intimately involved in neurological disea

199 The burgeoning field of epigenetics is making a significant impact on our unders

200 Epigenetics is receiving growing attention in the plant

201 Epigenetics is the study of biochemical modifications ca

202 A key challenge in epigenetics is to determine the biological significance

203 ce the human genome was sequenced, the term "epigenetics" is increasingly being associated with the h

204 The epigenetics landscape of cells plays a key role in the e

205 o emerge, as are the roles of the metabolism-epigenetics link in tumorigenesis.

206 Functional analyses identifies epigenetics marks, gene ontology categories and disease

207 ide methylation patterns, and to what extent epigenetics may be involved in environmental stress resp

208 velopment and disease are poorly understood: epigenetics may be involved.

209 Epigenetics may in part facilitate heritability.

210 control of normal stem cell differentiation, epigenetics may offer a useful arena to develop strategi

211 It is now clear that epigenetics may play a central role in the development o

212 Chromatin modifications and epigenetics may play important roles in many plant proce

213 te that non-clinical factors (e.g. genetics, epigenetics) may have more potential to predict longer t

214 This indicates that neuroimaging and epigenetics measures of ageing can provide complementary

215 tle is known about a possible direct role of epigenetics, mediated by 24-nt sRNAs, in the induction o

216 inases and intracellular signaling pathways, epigenetics, metabolism, nuclear-cytoplasmic transport,

217 Additional research investigating epigenetics, metabolomics, and microbiome holds promise

218 hways, including microsatellite instability, epigenetics, microbiota, and microenvironment.

219 involved in inflammation, oxidative stress, epigenetics, mitochondrial dysfunction, the gut microbio

220 The mechanisms are largely unknown, but epigenetics most likely plays a role.

221 with Max-Planck-Institute of Immunology and Epigenetics (MPI-IE), Freiburg, Germany).

222 at affects potential markers associated with epigenetics, neuronal, glial, and vascular components of

223 rapidly take a snapshot of the genetics and epigenetics of each specific human centromere in nondisj

224 , we compare and contrast the mechanisms and epigenetics of EBV early and late gene expression.

225 tant questions about gene expression and the epigenetics of Goltz syndrome-associated mutations and t

226 Beyond the epigenetics of mechanosensing, the scaling in cancer of

227 nsiders selected updates on the genetics and epigenetics of smoking behavior and associated cardiovas

228 This Review summarizes recent studies in the epigenetics of social behaviour and offers perspectives

229 issue, and open a new era of research on the epigenetics of stem cell aging that may represent therap

230 opose two key principles that may govern the epigenetics of stress and glucocorticoids along the life

231 the development of osteoarthritis, however, epigenetics of subchondral bone has not been extensively

232 deficient GIST that faithfully maintains the epigenetics of the parental tumour, including hypermethy

233 s demonstrate that targeting MUC1-C disrupts epigenetics of the PARP1 complex, inhibits PARP1 activit

234 A deep understanding of epigenetics offers the potential for fresh insights into

235 To understand the impact of epigenetics on human misfolding disease, we apply Gaussi

236 In addition, nutritional factors, epigenetics, or endocrine disrupting chemicals are poten

237 r macrophages by targeting immunometabolism, epigenetics, or the cytokine milieu holds promise in res

238 The Keystone Symposium on Chromatin and Epigenetics, organized by Luciano Di Croce (Center for G

239 We formed the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across

240 Within the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the asso

241 ected from Caucasian cohorts have found that epigenetics, particularly cytosine methylation, could pl

242 and psychiatric disorders, it is unclear how epigenetics, particularly DNA methylation, relate to bra

243 ave been made in our understanding of cancer epigenetics, particularly regarding aberrant DNA methyla

244 We address the relevance of epigenetics, pharmacogenomics, genetic testing and couns

245 There is emerging evidence that epigenetics play an important role in health and disease

246 Epigenetics plays a key role in cellular development and

247 Epigenetics plays critical roles in controlling stem cel

248 Changes in gene expression via epigenetics present a plausible mechanism.

249 methylation have not established population-epigenetics principles to guide design, efficient statis

250 National Institutes of Health (NIH) Roadmap Epigenetics Program have now annotated more than 80% of

251 nscriptome, post-transcriptional regulation, epigenetics, proteomics, metabolomics, and the microbiom

252 Epigenetics refers to changes in phenotype that are not

253 Epigenetics refers to heritable changes in patterns of g

254 The term epigenetics refers to stable patterns of gene expression

255 The term epigenetics refers to the heritable changes in gene expr

256 The term "epigenetics" refers to regulatory mechanisms that contro

257 Emerging evidence suggests that epigenetics regulates telomere dynamics in adults.

258 The term epigenetics relates to changes in gene expression that a

259 ratio and OXPHOS, and eventually upregulate epigenetics remodeling complex SWI/SNF in CHME-5 cells.

260 (OXPHOS), BRSKs, CDC25B/C, MAP/Tau, Wee1 and epigenetics remodeling complex SWI/SNF.

261 Thus refocused, epigenetics research aligns with the field of functional

262 m, we explore how non-human animal research, epigenetics research and genome-wide association studies

263 Here, we summarize current progress on HBV epigenetics research and the therapeutic implications fo

264 er the state of the science in environmental epigenetics research and to focus on DNA methylation and

265 The field of epigenetics research developed rapidly and provided us w

266 more than 3 decades ago, progress in cancer epigenetics research has been exponential.

267 Surprisingly, epigenetics research is still limited in ecotoxicology.

268 field of biomedicine during the last years, epigenetics research is surprisingly very limited in eco

269 erves as a central experimental technique in epigenetics research, yet there are serious drawbacks: i

270 gs, and discuss the future for environmental epigenetics research.

271 an cell types provides a new tool for cancer epigenetics research.

272 e utilization of this powerful technology in epigenetics research.

273 ope will be of broad utility to the field of epigenetics research.

274 at the intersection between neurobiology and epigenetics, Rett syndrome (RTT) has garnered intense in

275 sents a new area to explore in translational epigenetics.Significance: This study offers a first look

276 We silenced 608 genes in parallel using an epigenetics siRNA library and used an unbiased Fourier a

277 ding the role of PRMTs in stem cell biology, epigenetics, splicing, immune surveillance and the DNA d

278 For many years, cancer epigenetics studies relied on the identification of DNA

279 In the field of epigenetics, such screening methods have suffered from a

280 variant counterparts, is an entire branch of epigenetics that has received limited attention in the b

281 RE (gene expression prediction by long-range epigenetics), that quantifies the collective effects of

282 ancements suggest a potentially key role for epigenetics - the regulation of gene expression by nonco

283 Albeit in respect to epigenetics, this concept has been challenged.

284 To begin to understand the contribution of epigenetics to ASD, we have examined DNA methylation (DN

285 c inheritance and summarize the data linking epigenetics to cardiovascular disease.

286 es, and the existing human sepsis studies in epigenetics to demonstrate that epigenetic mechanisms ar

287 y a direct genetic basis, but the utility of epigenetics to improve complex traits is unclear.

288 Here, we specifically define epigenetics to include the key aspects of heritability (

289 The application of epigenetics to investigate the enantioselective toxicity

290 mber of central biological pathways spanning epigenetics to one-carbon metabolism.

291 to discuss the relevance of research in pain epigenetics to patients with persistent pain after thora

292 ic analyses to elucidate the contribution of epigenetics to plant phenotypes, stress responses, adapt

293 The central importance of epigenetics to the aging process is increasingly being r

294 ion and highlight the major contributions of epigenetics, transcription factors, and nuclear architec

295 aborate system, particularly with respect to epigenetics, transcription, and noncoding RNAs.

296 ic sessions on clinical trials, genetics and epigenetics, tumor microenvironment, immune suppression,

297 rmore, metabolic alterations directly impact epigenetics well beyond classical mechanisms of tumor pa

298 ucts is a powerful tactic to study bacterial epigenetics, which is poised to make novel and far-reach

299 across generations, clarify the interplay of epigenetics with genetics and sex, and suggest that CpG

300 ) plasticity, niche construction theory, and epigenetics with transgenerational epigenetic inheritanc