ライフサイエンスコーパス: epigenome

1 s in metabolite availability to regulate the epigenome.

2 l to advance our understanding of the phased epigenome.

3 ntributions of non-coding variants in cancer epigenome.

4 iate male gametes and reprogram the paternal epigenome.

5 coherence across different layers of the CLL epigenome.

6 via cellular metabolism are modifiers of the epigenome.

7 ture of the complexity between aging and the epigenome.

8 causes unintended changes to the genome and epigenome.

9 l crosstalk between bioactive amines and the epigenome.

10 at some of the highest levels in the myeloma epigenome.

11 tation cause profound changes in the nuclear epigenome.

12 result in markedly different changes to the epigenome.

13 ferentially methylated regions (DMRs) in the epigenome.

14 , is a crucial regulator of the mouse oocyte epigenome.

15 nds of somatic alleles altering the prostate epigenome.

16 ate cancer genomes and the prostate-specific epigenome.

17 fects in multiple aspects of the Arabidopsis epigenome.

18 g), in part shaped by the inherited parental epigenome.

19 us far from the study of the prostate cancer epigenome.

20 n profiles in the context of 5 MCL reference epigenomes.

21 g a more complete understanding of bacterial epigenomes.

22 modification not commonly found in metazoan epigenomes.

23 for the site-specific manipulation of plant epigenomes.

24 t an undirected, radical erasure of parental epigenomes.

25 n important resource for modulating cellular epigenomes.

26 wide profiling of the transcriptome and the epigenome, a critical regulator of gene expression.

27 associated with profound alterations of the epigenome, a systematic view of epigenetic factors in re

28 ytotoxic T cell differentiation is guided by epigenome adaptations, but how epigenetic mechanisms con

29 tau protein burden had a broad effect on the epigenome, affecting 5,990 of 26,384 H3K9ac domains.

30 epigenetic regulators and maintenance of the epigenome after heat shock.

31 Epigenome analyses indicated that butyrate redistributed

32 mprove human annotation, developments in our epigenome analysis and display, a new tool for imputing

33 identified and validated through integrative epigenome analysis.

34 iers is of utmost importance to preserve the epigenome and consequently appropriate cellular function

35 research on interventions to rejuvenate the epigenome and delay ageing processes.

36 ead sequencing can simultaneously survey the epigenome and detect somatic TE mobilization.

37 porter assays (MPRA) with cell-type-specific epigenome and expression quantitative trait loci (eQTL)

38 lly altered, highlighting known links to the epigenome and proposing other plausible connections.

39 mogenesis through coordinated effects on the epigenome and RNA splicing.

40 The epigenome and three-dimensional (3D) genomic architectur

41 ed here suggest that integrative analysis of epigenome and transcriptional programs could identify ta

42 However, how PTEN deletion would impact the epigenome and transcriptome alterations remain unknown.

43 Integrative cistrome, epigenome and transcriptome analysis identifies the lipi

44 This activity dynamically reshapes the epigenome and transcriptome by depositing oxidized 5mC d

45 We generated matched epigenome and transcriptome measurements in 86 primary c

46 tion at thousands of genomic loci, i.e., the epigenome and transcriptome of its target tissues.

47 cise on leukocyte production and on the HSPC epigenome and transcriptome persists for several weeks.

48 omal and epithelial cell changes in both the epigenome and transcriptome that ultimately lead to pros

49 cid might modify risk through effects on the epigenome and transcriptome, and new approaches to study

50 SD with shared dysregulation across both the epigenome and transcriptome.

51 r and highlight the relationship between the epigenome and transcriptome.

52 an important step for functional studies of epigenomes and epigenomics-based precision medicine.

53 nal PNETs fall into two major subtypes, with epigenomes and transcriptomes that partially resemble is

54 encompass a quarter of the human regulatory epigenome, and 47% of elements can be in an active regul

55 treme, sex-specific dynamism of the neuronal epigenome, and establishes a foundation for the developm

56 uanced relationships between the genome, the epigenome, and gene expression.

57 rent chromatin state patterns along a single epigenome, and many of these patterns carry cell-type-sp

58 cer-associated non-coding variants in cancer epigenome, and to facilitate the identification of funct

59 ta from the gut microbiome, metabolome, host epigenome, and transcriptome in the context of irritable

60 IDEAS as our integrative and discriminative epigenome annotation system, we identified and assigned

61 Our comprehensive epigenome annotations and 3D genome maps serve as valuab

62 approaches for targeted manipulation of the epigenome are available in plants.

63 vides the first evidence that changes in the epigenome are detectable in children with perinatally-ac

64 Drugs that modify the epigenome are powerful tools for treating cancer, but th

65 Two major functions of the epigenome are to regulate gene expression and to suppres

66 t of risk-conferring alleles by exposing the epigenome as an exploitable target for therapeutic inter

67 al advantages and challenges associated with epigenome-based therapeutics for OA.

68 ysfunction, act as senolytics and impact the epigenome by altering one-carbon metabolism.

69 ults suggest that PBB153 exposure alters the epigenome by disrupting methyltransferase activity leadi

70 dual role in safeguarding the genome and the epigenome, by performing the last of the multiple steps

71 es, genetic diversity, genome structure, and epigenome changes associated with domestication.

72 ematode effector proteins in triggering such epigenome changes is discussed.

73 ) models that were derived from whole-tissue epigenome chromatin data.

74 the first time across the transcriptome and epigenome combined, this study identifies novel differen

75 allowing us to generate a fully phased human epigenome, consisting of chromosome-level allele-specifi

76 Epigenome constitutes an important layer that regulates

77 An epigenome CRISPR-CAS9 knockout (KO) screen identifies AR

78 By incorporating epigenome data to estimate the functional importance of

79 resents a challenge to the interpretation of epigenome data, compounded by the difficulty in generati

80 rther demonstrated by comparisons to the 127-epigenome dataset released by the Roadmap Epigenomics pr

81 pre-compiled the comparable human and mouse epigenome datasets in matched cell types and tissues fro

82 regulated drivers of HCC and elucidating how epigenome deregulation contributes to liver disease and

83 Dysregulation of the epigenome drives aberrant transcriptional programmes tha

84 In this study, we have characterized the epigenome during the in vitro differentiation of human m

85 Using epigenome editing and 3C assays, we demonstrated a causa

86 Here, we used a novel CRISPR-based epigenome editing approach to control gene expression sp

87 This review focuses on new state-of-the-art epigenome editing approaches to modify the epigenome of

88 niques to perform high-throughput genome and epigenome editing can be paired with a variety of readou

89 Epigenome editing experiments revealed that two of them

90 Analysis of Hi-C data and epigenome editing experiments shows that Rgcc is the pri

91 irology, and CRISPR engineering is advancing epigenome editing into a new era.

92 Epigenome editing refers to the generation of precise ch

93 Here, we investigate epigenome editing strategies for perturbing individual C

94 molecule screening and CRISPR/Cas9-mediated epigenome editing that offer promising therapeutic optio

95 the promising application and challenges of epigenome editing to tackle brain disorders.

96 Development of epigenome editing tools enables a functional dissection

97 Here, we review the development of epigenome editing tools, summarize proof of concept appl

98 Until recently, much of the efforts in epigenome editing were limited to tissue culture models

99 Recent advances in molecular profiling and epigenome editing, combined with the use of comparative

100 ver at the DNA target site during genome and epigenome editing.

101 e achieved through combinatorial hit-and-run epigenome editing.

102 grammable platform for eukaryotic genome and epigenome editing.

103 We briefly introduce three epigenome-editing platforms: zinc-finger proteins, trans

104 trong confounding fitness effects with these epigenome-editing tools.

105 corresponding corrected lines by genome- and epigenome-editing.

106 opulation and single-cell levels with genome/epigenome engineering in vivo, we identify multiple regu

107 These findings demonstrate the importance of epigenome:environment interactions, which early in life

108 yltransferase (DNMT) that mediates long-term epigenome evolution.

109 sing ATAC-seq and characterize combinatorial epigenome features around these OCRs using ChIP-seq, Bis

110 tial of deep learning models - which predict epigenome features from DNA sequence - to support infere

111 plex relationship between metabolism and the epigenome, focusing on the roles of essential metabolic

112 enzymes to set the methylation status of the epigenome for proper control of gene expression and meta

113 homeostasis, functioning to safeguard the SC epigenome from a breach in lineage confinement that othe

114 body methylation, which distinguishes fungal epigenomes from certain insect and plant species.

115 regulators combined with disruptions in the epigenome hallmarked by profound loss of 5hmC, locus-spe

116 The human epigenome has been experimentally characterized by thous

117 We propose that an epigenome has been propagated for >50 million years thro

118 ct of this intracellular pathogen on the bAM epigenome has not been determined.

119 ofiling of cancer genomes, transcriptomes or epigenomes has been performed in this population thus fa

120 gene expression including alterations of the epigenome have been characterized(1-8).

121 are reversible, and therapies targeting the epigenome have been implicated in potential reinvigorati

122 Recent efforts to describe the human epigenome have yielded thousands of epigenomic and trans

123 -estradiol (E2) affects the behavior and the epigenome in a mouse model carrying a single-nucleotide

124 Overall, our results support a role of the epigenome in clonal evolution and uncover new candidate

125 e utility of studying the cell-type-specific epigenome in complex tissues like the human brain, and t

126 ell-type-specific chromatin organization and epigenome in complex tissues.

127 ibit prominent capacity of co-regulating the epigenome in cooperation with EWS-FLI1, occupying 77.2%

128 r paternal high fat (HF) diet can modify the epigenome in germ cells and fetal somatic cells leading

129 monstrate that glucolipotoxicity changes the epigenome in human islets, thereby altering gene express

130 primary component of FireMaster, alters the epigenome in human spermatogenic cells.

131 tion of genes, early-life adversity, and the epigenome in influencing gene expression is now being in

132 s to a greater evolutionary potential of the epigenome in invertebrates than there is in mammals.

133 These findings uncover how the distinctive epigenome in neurons facilitates the development and fun

134 Understanding the role of the epigenome in protein-misfolding diseases remains a chall

135 nies these changes(6-8), but the role of the epigenome in regulating early cell-fate choice remains u

136 ly, allelic mapping of the transcriptome and epigenome in SmcHD1 mutant cells reveals the appearance

137 zymes play essential roles in remodeling the epigenome in the zygote and cleavage stage embryos, when

138 e, we report how loss of SMARCB1 affects the epigenome in these tumors.

139 ons of regulatory transcription networks and epigenomes in hepatocytes.

140 The epigenome, including DNA methylation, is stably propagat

141 leads to extensive alterations of the oocyte epigenome, including the loss of H3K36me3, failure in es

142 The epigenome integrates information from sequence variation

143 ys a crucial role in preserving the maternal epigenome integrity required for proper zygotic genome a

144 textual regulation of transcription factor - epigenome interaction.

145 ilitate comprehensive studies of environment-epigenome interactions.

146 f a specific cell type for transcriptome and epigenome interrogation that decreases dependency on tra

147 The nasal epigenome is a sensitive biomarker of asthma, allergy an

148 The CLL epigenome is also an important disease-defining feature(

149 epigenetic profile of how and when the liver epigenome is perturbed during progression to HCC.

150 ficity of CRISPR/dCas9/12a to manipulate the epigenome is rapidly becoming a highly promising strateg

151 Precisely how the paternal epigenome is reprogrammed in flowering plants has remain

152 Studying genome and epigenome led to the fundamentals of development and pro

153 This metabolism-epigenome link sensitizes chromatin methylation to alter

154 Thus, the DCs epigenome links inherited susceptibility and clinically

155 structed through integrative analysis of the epigenome map, and a knockout of a predicted upstream re

156 These spatiotemporal epigenome maps provide a resource for studies of gene re

157 We produce epigenome maps, including DNA methylation and chromatin

158 Alterations in the brain epigenome may orchestrate changes in gene expression tha

159 The nasal cellular epigenome may serve as biomarker of airway disease and e

160 s work has indicated that alterations in the epigenome might contribute to clonal selection, yet the

161 ch allows rapid depletion of the dCas9-fused epigenome modifier complex from the target site and enab

162 To identify functionally important epigenome-modifying enzymes and genome regions where met

163 The epigenome-modifying NCOR complex is sensitive to many AS

164 lar profiling of the transcriptome (n = 25), epigenome (n = 24) and genome (n = 21) of CPM and matche

165 nce of germline polymorphisms on the somatic epigenome of 589 localized prostate tumors.

166 Mechanistically, BCL6 remodels the epigenome of brown adipocytes to enforce brown and oppos

167 made in the understanding of its genome, the epigenome of C. difficile and its functional impact has

168 Here, we demonstrate that AMPK maintains the epigenome of MLL-rearranged AML by linking acetyl-coenzy

169 nflammation have the potential to affect the epigenome of neighboring cells.

170 t epigenome editing approaches to modify the epigenome of neoplasms and other disease models towards

171 cate crosstalk between the germ line and the epigenome of primary tumors, which may help identify ger

172 s associated with significant changes in the epigenome of the infants.

173 Alterations to the epigenome of uterine cells may therefore contribute sign

174 nitial findings were extended to genomes and epigenomes of 1,044 medulloblastoma cases from internati

175 chromatin states defined in this study with epigenomes of cell-types defined by the Roadmap Epigenom

176 rk ChIP-seq to define the transcriptomes and epigenomes of cells representing key developmental stage

177 profiling the single-cell transcriptomes and epigenomes of cerebral organoids derived from human, chi

178 neration, we compared the transcriptomes and epigenomes of regenerative and nonregenerative mouse hea

179 The epigenome offers an additional facet of cancer that can

180 This work emphasizes the importance of epigenome plasticity in cancer development and highlight

181 Although regulation of the epigenome plays a key role in shaping stem cell hierarch

182 The oocyte epigenome plays critical roles in mammalian gametogenesi

183 Targeting metabolism and/or the epigenome presents a unique opportunity for rational the

184 generating time-resolved transcriptomes and epigenome profiles during oncogenic RAS-induced senescen

185 whole-blood transcriptome and CD4(+) T-cell epigenome profiles to identify molecular signatures of r

186 lant research, genome-wide transcriptome and epigenome profiling during the vernalization response ha

187 Extensive efforts have been made to develop epigenome profiling methods using a low number of cells

188 Epigenome profiling of multiple cellular models of chemo

189 CLE), which spans the genome, transcriptome, epigenome, proteome and metabolome, thereby providing co

190 applying single-cell genome, transcriptome, epigenome, proteome, and metabolome analyses to gastroen

191 stone lysine methylation dynamics across the epigenome regulates virtually all DNA-templated processe

192 d the fate of pluripotent stem cells through epigenome regulation is emerging.

193 of imperfect DNA methylation maintenance and epigenome reinforcement events that occur in specialized

194 he metabolic function of AMPK alters the AML epigenome remains unknown.

195 Environmental stress produces epigenome remodeling events within TIL resulting from lo

196 Together, our results suggest that 3D epigenome remodelling is a key mechanism underlying endo

197 al network to predict sub-compartments using epigenome, replication timing, and sequence data.

198 ated genome-wide chromatin interaction maps, epigenome, replication-timing, whole-genome bisulfite se

199 we show that the extensive transcriptome and epigenome resetting during the conversion between 'serum

200 genomes, the analysis of the D. gyrociliatus epigenome revealed canonical features of genome regulati

201 Analysis of the intratumoral epigenome revealed increased 5hmC with AA treatment, con

202 z to create a custom genome browser from the Epigenome Roadmap dataset.

203 esis, we characterized soybean (Glycine max) epigenomes sampled from embryos at 10 different stages r

204 However, whether epigenome sequencing technologies will be feasible for r

205 apply two independent screens, BioID and an Epigenome shRNA dropout screen, to define ZEB1 interacto

206 hat accounts for both sequence alignment and epigenome similarity.

207 We validate EPISCORE in multiple epigenome studies and tissue types.

208 a loss of hemispheric asymmetry in neuronal epigenomes, such that hemispheres epigenetically converg

209 for understanding disease and the future of epigenome-targeting therapies.

210 ve greater hemispheric asymmetry in neuronal epigenomes than those with a short disease course.

211 in 'readers' are central interpreters of the epigenome that facilitate cell-specific transcriptional

212 crucial player in establishing the maternal epigenome that in turn controls embryonic development.

213 toplasmic signaling networks and the nuclear epigenome that synergistically regulate macrophage immun

214 that short-chain fatty acids can affect the epigenome through metabolic regulatory receptors in dist

215 ended Il9 locus and broadly modified the Th9 epigenome through RARalpha.

216 ing proteins are important regulators of the epigenome through their ability to recognize N-acetyl ly

217 trate that (m)Ca(2+) signaling regulates the epigenome to influence cellular differentiation.

218 active roles metabolism plays in shaping the epigenome to influence patterns of gene expression that

219 dynamics, we performed a survey spanning the epigenome to translatome of Arabidopsis (Arabidopsis tha

220 re mutations activate enhancers in CRC tumor epigenomes to provide a selective advantage.

221 ograms PFA metabolism and, subsequently, the epigenome toward H3K27 hypomethylation, mirroring transc

222 erived macrophages that exhibited convergent epigenomes, transcriptomes, and functions.

223 We profiled the genomes, epigenomes, transcriptomes, and proteomes of 76 localize

224 opment are governed by the transcriptome and epigenome, two levels of gene regulation that have the p

225 Predisposition risk loci influence a tumor's epigenome, uncovering a mechanism for cancer susceptibil

226 Paternal and maternal epigenomes undergo marked changes after fertilization(1)

227 Evolution of the epigenome was associated with pathways previously linked

228 Alterations of the genome and epigenome were correlated and were predictive of disease

229 st that AD involves a reconfiguration of the epigenome, wherein H3K27ac and H3K9ac affect disease pat

230 he complex, large scale analyses required in epigenome wide association studies (EWAS) without the ne

231 For diet-associated CpGs identified in epigenome-wide analyses, we conducted Mendelian randomiz

232 ved within the PTSD group observed following epigenome-wide analysis of a well-characterized Discover

233 We perform nasal Epigenome-Wide Association analyses (EWAS) of current as

234 onducted ethnicity-specific and trans-ethnic epigenome-wide association analyses for diet quality and

235 We performed epigenome-wide association analyses of placental DNA met

236 Through epigenome-wide association analysis of DNA methylation f

237 d neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to

238 Epigenome-wide association studies (EWAS) further identi

239 In case-control and case-only epigenome-wide association studies (EWAS) of preputial t

240 Few epigenome-wide association studies (EWAS) on air polluta

241 outcome data (e.g., DNA methylation data in epigenome-wide association studies (EWAS)), because ever

242 proaches using genome-wide designs including epigenome-wide association studies (EWAS), to increase s

243 Epigenome-wide association studies (EWAS), which seek th

244 heterogeneity hampers the interpretation of Epigenome-Wide Association Studies (EWAS).

245 Epigenome-wide association studies (EWASs) have become i

246 Epigenome-wide association studies identified the cg0057

247 fication of epigenetic signatures of DKD via epigenome-wide association studies might also inform pre

248 In this meta-analysis of epigenome-wide association studies of 8,825 neonates fro

249 We conducted epigenome-wide association studies of hepatic fat in 3,4

250 Therefore, we conduct genome- and epigenome-wide association studies on the levels of 92 n

251 This is one of the first epigenome-wide association studies to investigate As exp

252 pment of type 1 diabetes (T1D), but previous epigenome-wide association studies were conducted among

253 wide manner using array-based technology for epigenome-wide association studies.

254 vide a new interpretation of cross-sectional epigenome-wide association studies.

255 We conducted the largest DNA methylation epigenome-wide association study (EWAS) analyses current

256 We first separately conducted an epigenome-wide association study (EWAS) for phosphatidyl

257 Our epigenome-wide association study (EWAS) of human blood r

258 on at the methylation level, we conducted an epigenome-wide association study (EWAS) of MetS and its

259 We conducted the first epigenome-wide association study (EWAS) of OD in a sampl

260 We report the first epigenome-wide association study (EWAS) of smoking in hu

261 In this study we performed an epigenome-wide association study (EWAS) to assess the as

262 We report the first epigenome-wide association study meta-analysis of adult

263 Here, we report an epigenome-wide association study of 1123 proteins from 9

264 rly phases of T2D pathology by a blood-based epigenome-wide association study of 4808 non-diabetic Eu

265 umption is associated with methylation in an epigenome-wide association study of blood and normal bre

266 We conducted an epigenome-wide association study of eGFR among 567 HIV-p

267 A large-scale epigenome-wide association study of folate and vitamin B

268 A standard epigenome-wide association study of lifetime exposure (v

269 We conducted an epigenome-wide association study of urine Cd and self-re

270 Allergy (MeDALL) consortium, we performed an epigenome-wide association study of whole blood DNA meth

271 We conducted an epigenome-wide association study using the histone 3 lys

272 An epigenome-wide association study was performed in the Ne

273 Through an epigenome-wide association study we explored CpG sites a

274 the AFGen 2017 GWAS; (2) a whole blood EWAS (Epigenome-Wide Association Study) of AF; and (3) a whole

275 , lowest p value (genome-wide association or epigenome-wide association study), and estimated effect

276 frican American children were included in an epigenome-wide association study.

277 cancer (HGSOC) patients in which we assessed epigenome-wide association using Illumina methylationEPI

278 s from the United States and Europe profiled epigenome-wide blood leukocyte DNA methylation using the

279 Using a training-testing approach, epigenome-wide CpGs associated with asthma were identifi

280 sters, have a significantly higher impact on epigenome-wide DNA methylation changes in CD4 T cells co

281 Epigenome-wide DNA methylation levels in AECs, NECs and

282 Epigenome-wide DNA methylation was analysed in individua

283 horts, totalling 3337 individuals, we report epigenome-wide meta-analyses of blood DNA methylation wi

284 ildhood Epigenetics consortium, we performed epigenome-wide meta-analyses of school-age asthma in rel

285 tosine-phosphate-guanine sites were used for epigenome-wide methylation analyses.

286 estimate effect size, we performed the first epigenome-wide methylation analysis of whole blood DNA s

287 In contrast, no CpG reached epigenome-wide significance on self-reported alcohol con

288 35 regions) were differentially methylated (epigenome-wide significance, false discovery rate < 0.05

289 < 5.4 x 10(-10)) loci for 33 proteins and 26 epigenome-wide significant (P < 3.9 x 10(-10)) sites ass

290 We identify two previously unreported epigenome-wide significant associations with PD, includi

291 One epigenome-wide significant differentially methylated pos

292 ng DNA extracted from peripheral leukocytes, epigenome-wide single nucleotide resolution of DNA methy

293 HPCAL1), and genes identified in genome- and epigenome-wide studies of serum calcium (CASR), serum ca

294 lumina MethylationEPIC array and the largest epigenome-wide study of As exposure.

295 ylation status at single CpG site resolution epigenome-wide, is a powerful technique for use in molec

296 differentially methylated sites derived from Epigenome-Wide-Association Studies (EWAS) remains a sign

297 es in whole blood have been reported by many Epigenome-Wide-Association Studies (EWAS).

298 tinue to be deciphered, we envision that the epigenome will become an important therapeutic target fo

299 extensive data connecting alterations in the epigenome with tumor formation, initial experiments atte

300 f the microdeletion on the transcriptome and epigenome, with disruptions in several neuropsychiatric