ライフサイエンスコーパス: epimer

1 hydroxy acid 25 (Ki = 1.5 mM as a mixture of epimers).

2 ompact or "closed" conformer shared with the epimer.

3 ion was also induced by largazole and its C2 epimer.

4 trans-5R,6R equilibrium favors the cis-5R,6S epimer.

5 the undesired but thermodynamically favored epimer.

6 nd it was also more cytotoxic than the 6beta-epimer.

7 ctone core, and furnished EBC-23 and its C11 epimer.

8 is thermodynamically more stable than its 19-epimer.

9 different conformational properties of each epimer.

10 action rates for radical formation from each epimer.

11 s were 14-216 times more potent than the (S) epimers.

12 at lead to two unequally populated rotameric epimers.

13 oth mannuronate and guluronate, which are C5 epimers.

14 ys an important role in distinguishing these epimers.

15 und exists in an equilibrium between several epimers.

16 n the coprolite had been converted to sterol epimers.

17 rm for the separation of 25-hydroxyvitamin D epimers.

18 e) and the C2-epimerization of D-arabinarate epimers.

19 yntheses of these natural products and their epimers.

20 e) as the alpha (C4'alpha) or beta (C4'beta) epimers.

21 xist as a mixture of rapidly interconverting epimers.

22 phered via the syntheses of both of its C7'' epimers.

23 reater destabilization characteristic of (R)-epimers.

24 ated counterparts than the corresponding (R)-epimers.

25 from potential interferences, especially its epimers.

26 staglandins, lipoxins, and their natural C15-epimers.

27 quenching of 14a provides access to the 7(R)-epimer (14b).

28 d structure of cycloinumakiol (1) and its C5 epimer (18) are achieved in a concise and efficient fash

29 Both 1a and its 8-endo epimer 1b experience appreciable epimerization and fragm

30 The 8-endo epimer 1b, which yields no [1,3] product, experiences pr

31 transformed to neplanocin A (1a) and its 3'-epimer (1b).

32 The C-2 epimer, (1R/S,4R/S)-6R/S-(N, N-dimethylamino)-5R/S-pheny

33 The conformers of epimers (1S)-2e,f show high rotational barriers of up to

34 trated that the parent nucleoside and its 2'-epimer 2'-C-cyano-2'-deoxy-2-ribo-pentofuranosylcytosine

35 in contrast to that of its D-apio-L-furanose epimer 2, was readily incorporated into a DNA template b

36 racid-1 (1), the syntheses of its C(1)-C(20) epimer (2) and of several truncated analogues for biolog

37 total synthesis of psymberin (1) and its C4 epimer (2).

38 the targeted compounds (1a,b) and their C-20 epimers (2 and 3).

39 The epimer 20(R)-Rg3 was inactive.

40 ixture of the desired PMB product 21 and the epimer 23.

41 The corresponding deshydroxy epimer (3'S)-14 was 7-fold more potent than its 3'R coun

42 cyclic uracil polyoxin C (+)-2 and its alpha-epimer (-)-3 were synthesized in an efficient fashion fr

43 sing ion mobility; in contrast, the inactive epimer, 3-epi-25-hydroxyvitamin D (epi25OHD), only adopt

44 quilibration between alantrypinone 4 and its epimer 31 or between its ester analogues 23 and 24 has b

45 (3), (15R)-vinyl-nor-brefeldin A (5), their epimers 4 and 6 as well as (15S)-ethyl-nor-brefeldin A (

46 t the human metabolite of DHA is the 12alpha-epimer 5.

47 Mitsunobu inversion of the C-7 alcohol 51 to epimer 52, and conversion of this compound to tetracycli

48 binding modes lead mainly to the ineffective epimer 6-epi-pravastatin.

49 udy was performed on the complex formed from epimer A and a recombinant, uniformly (15)N-labeled F22W

50 ssignment of the earlier 7R configuration of epimer A and the 7S configuration of epimer B.

51 hain nitrogens of Lys135 in epimer B than in epimer A.

52 ise to a previously inaccessible spiroacetal epimer, a new method to synthesize thioketene acetals fr

53 different chemical yields obtained from each epimer, a result not rationalized by the previous model.

54 of beta-(1, 4)-D-mannuronate (M) and its C-5 epimer alpha-(1, 4)-L-guluronate (G).

55 Interestingly, the C-2 epimer alpha-D-talose binds almost as well as D-galactos

56 beta(R)-epimers were preferred to 1 alpha(S)-epimers, although ipecoside (1 beta(R)) is a major alkal

57 solution mass spectrometry (TIMS-CID-MS) for epimer analysis.

58 B2 is over 12-fold more potent than the C8,9-epimer and C18-epimer in human DU145 prostate cancer cel

59 In addition to RvD1, its aspirin-triggered epimer and RvD1 analogs each dose dependently and effect

60 the anomeric center than in its unnatural 7R-epimer and, therefore, better able to support incipient

61 demonstrated for Cinchonine and Cinchonidine epimers and amino alcohol enantiomers, from which the qu

62 ve recently identified several highly active epimers and analogues.

63 iological roles of 1 alpha(S)- and 1 beta(R)-epimers and for the involvement of IpeGlu1 in the metabo

64 demonstrated by its reduction to two alcohol epimers and its reaction with a methylene ylide.

65 lective total syntheses of omuralide, its C7-epimer, and (+)-lactacystin.

66 ce for the unnatural epimer over the natural epimer, and a slower overall rate of peptide coupling.

67 techin-3-gallate, (-)-epicatechin, and their epimers, and black tea polyphenols, theaflavin, theaflav

68 y carbon source D: -glucose, various glucose epimers, and several acetylated hexosamines.

69 (18)F-hGTS13 was separated into C5 epimers, and the corresponding (18)F-hGTS13-isomer1 and

70 d SR-A3 and SS-A3-two out of 128 possible A3 epimers-and discovered that synthetic SR-A3 is indisting

71 Thus, the DNA ligands can discriminate sugar epimers, anomers, and disaccharide linkages.

72 alkaloid cycloclavine and its unnatural C(5)-epimer are described.

73 ilignan natural product tatanan A and its C3 epimer are described.

74 ifferences between this isomer and its (16R)-epimer are only +/-5-10 ppb (+/-0.005-0.01 ppm).

75 Adenosine (Ado)-5'-carboxaldehyde and its 4'-epimer are potent inhibitors of S-adenosyl-L-homocystein

76 udies established that the precatalyst axial epimers are all converted into the catalytically active

77 When pairs of C-4 epimers are available, the rule indicates that, when the

78 Lipoxins and their aspirin-triggered 15-epimers are endogenous anti-inflammatory agents that blo

79 ructural analyses showed that the (S)-C5'-Me epimers are spatially and structurally more similar to t

80 separation and identification of uronic acid epimers as well as geometric sulfation isomers.

81 f the aldehyde group and condensation to the epimer at C-4.

82 synthesis of (+)-gabosine J and that of the epimer at C4 of its enantiomer have been accomplished th

83 conversion of d-erythronate and l-threonate (epimers at carbon-3) to dihydroxyacetone phosphate and C

84 Epimers at the 2-, 3-, and 4-position of xylose also wer

85 (1a) and D (1d) and their analogues 3a, 3d (epimers at the indicated site) and 4a, 4d (epimers at th

86 (epimers at the indicated site) and 4a, 4d (epimers at the indicated site).

87 The preparation of the two epimers at the quaternary carbon of the 6-deoxy-C-altros

88 lvin D1 (RvD1) and its aspirin-triggered 17R epimer (AT-RvD1) with compounds prepared by total organi

89 y from the side chain nitrogens of Lys135 in epimer B than in epimer A.

90 ments previously based solely on results for epimer B, a (15)N[(19)F] REDOR NMR study was performed o

91 tion of epimer A and the 7S configuration of epimer B.

92 e 473, with the orientation of the 20 carbon epimer being crucially important for biological activity

93 x copolymer of alpha-L-guluronate and its C5 epimer beta-D-mannuronate.

94 y crystallography revealed that only the (R) epimers bound in the crystal.

95 sed affinity and potency compared with the R-epimer, but was more rapidly inactivated than RvE1 by de

96 Quantitation of peptide epimers by RDD is also described.

97 ions obtained by EDD of the tetrasaccharide epimers can be rationalized by simple alpha-cleavage of

98 Fragmentation of epimers can enhance their identification and further imp

99 ulose (CDP-cereose) and likely generated a 4-epimer CDP-3-C-methyl-6-deoxyallose (CDP-cillose).

100 etic approach leading to the 1 alpha-hydroxy epimers complements our previously reported synthesis of

101 4 nM vs 159 nM for cocaine), whereas the C-8 epimer, compound 14, was somewhat less potent (IC(50) =

102 Both 4'-OMe epimers conferred increased nuclease resistance, which c

103 h E), which presumably was obtained from its epimer congener (ceph F) through an acid-mediated equili

104 leads to the production of two pairs of C1' epimers containing a pyranose and a furanose, respective

105 e in six steps; however, both alpha and beta epimers could be obtained by a nonstereoselective approa

106 AlsK phosphorylates the glucose epimer, d-allose, with a k(cat)/K(m) value of 6.5 x 10(4

107 thioether-cleaving activity with the beta(S)-epimer, demonstrating that LigG is a stereospecific beta

108 nation of distinct (1)D columns (for peptide epimer/diastereomer separations) and (2)D columns (for p

109 racid-3, whereas the previously assigned 20R epimer did not.

110 ions afford easily separable mixtures of two epimers differing in the configuration of the center der

111 in some cases with the use of metal adducts, epimer discrimination is optimized.

112 on forming equal amounts of two albaflavenol epimers, each of which is oxidized in turn to albaflaven

113 Lipoxins (LX) and their aspirin-triggered 15-epimer endogenous isoforms are endogenous anti-inflammat

114 lopregnanolone, but not its inhibitory 3beta-epimer epi-allopregnanolone, binds to the canonical beta

115 tubulysin U, tubulysin V, and its unnatural epimer epi-tubulysin V, is reported.

116 y an abrupt increase in coprostanol (and its epimer epicoprostanol) in the sediments and an associate

117 tudies are recommended to classify different epimers, especially of the phenolics and monoterpenoids

118 ric fragment ions resulting from d/l-peptide epimers exhibit conformational differences, thus showing

119 esulted in decreased activity, with only one epimer exhibiting anti-HIV activity.

120 padiformines A, B, and C as well as their C2 epimers, featuring divergent and stereoselective synthes

121 D-amino acid-containing peptides (which are epimers) for identification.

122 for the differentiation of both isomers and epimers, for the characterization of saccharide mixtures

123 The alpha-epimer generally conceded similar thermal stability as u

124 MlghC is specific for the double C3/C5 epimer generated by MlghB and produces L-gluco-heptose v

125 composed of mannuronic acid (M) and its C-5 epimer guluronic acid (G).

126 HA08, which is 100-fold more potent than the epimer HA09, can enhance dendritic spine number and alte

127 nantiomers of muricatacin as well as the C-5-epimer has been developed.

128 Separation of the epimers has been accomplished by RP-HPLC, allowing full

129 Two urinary steroid epimers have now been shown to be components of a courts

130 However, in this paper we show that the two epimers have similar conformational properties, which im

131 The epimer having the 6alpha-acetamido substituent was more

132 parate 25-hydroxyvitamin D from its inactive epimer; however, ion mobility spectrometry can distingui

133 o-oligosaccharides bearing d-glucose or a C5-epimer (i.e., l-idose or l-iduronic acid) conjugated wit

134 Distinguishing the epimers iduronic acid (IdoA) and glucuronic acid (GlcA)

135 to EDD, NETD is also able to distinguish the epimers iduronic acid from glucuronic acid in heparan su

136 old more potent than the C8,9-epimer and C18-epimer in human DU145 prostate cancer cells.

137 hat stereospecifically hydrolyzes 3 alpha(S)-epimer in terpenoid-indole alkaloid biosynthesis, IpeGlu

138 the cis-5R,6S and trans-5R,6R thymine glycol epimers in duplex DNA was affected by the identity of th

139 nvestigations of important but low abundance epimers in isomeric mixtures.

140 a unique peak but detected two peaks for the epimer, in contrast to the low-field methods that detect

141 Further transformations of each C(4)-OH epimer included the S(N)2 reaction with PyFluor followed

142 ne moiety were less potent, and only the (R)-epimer incorporating a larger 2-ethylbutyl P1' group sho

143 yzed hydrolysis of a mixture of C-35 acetoxy epimers indicated a 35R absolute configuration for 2.

144 ion resulted in up to 80% of the non-natural epimer, indicating that it can be the major product in s

145 one beta-position as an equimolar mixture of epimers, inferring rapid isomerization of the kineticall

146 The epimers involved in the isomerization mechanism were inv

147 The noncharged microspecies of the cis-epimer is 30 900 times as lipophilic as its zwitterionic

148 mer, while the analogous ratio for the trans-epimer is around 15 800.

149 conrotatory mode that leads to the C5-alpha epimer is disfavored due to higher levels of allylic str

150 the system can sense galactose as well, this epimer is not a potential interfering substance since it

151 8-OMs and 22-OMs in comparison to the 7alpha epimers is attributed to concerted antiperiplanar Wagner

152 molecules, even when only one of the two C2 epimers is available.

153 ard six ergot alkaloids and their respective epimers is described.

154 st is employed, a 5.3:1 equilibrium ratio of epimers is established quickly, but when a first-generat

155 products N-deacetylisoipecoside (1 alpha(S)-epimer) is considered to be a part of the reactions for

156 )-daphlongamine H, provided access to its C5-epimer, (-)-isodaphlongamine H, and led to structural re

157 ) and each pair of sugars can form different epimers (isomers around the stereocentres connecting the

158 epimerization of D-glucuronic acid to its C5-epimer L-iduronic acid, which is essential for the funct

159 nuronate (M) and variable amounts of its C-5-epimer, l-guluronate (G).

160 ir sequence, as d-glucuronic acid and its C5 epimer, l-iduronic acid, can both occur.

161 teins were compared using cellobiose and its epimer, lactose, as the substrates.

162 as unmodified nucleotides, whereas the beta-epimer led to significant destabilization.

163 VSEFLKQAWFIENEEQEYVQTVK), 2.5 mug/kg] and 15-epimer-lipoxin A4 (15-epi-LXA4; FPR2/ALX specific, 12.5

164 f carbon 15 epimeric LXs, and both series of epimers (LX and aspirin-triggered 15-epi-LX) display cou

165 e charge state were resolved in another, and epimers merged as protonated species were resolved upon

166 side, trachelosperogenin E, ellagic acid, an epimer mixture of (+)-gallocatechin and (-)-epigallocate

167 siRNAs containing several C4'alpha-epimer monomers in the sense or antisense strands trigge

168 emetine biosynthesis, whereas its 1 beta(R)-epimer N-deacetylipecoside is converted to ipecoside in

169 iven domain can vary in terms of uronic acid epimer, N- and O-sulfate, and N-acetate content.

170 om the far more abundant isobaric galactosyl epimers naturally occurring in white matter.

171 y reductive N-methylation, provided the C(2)-epimer of (-)-preussin B and (+)-preussin B as the major

172 preussin B over seven steps, 8% for the C(2)-epimer of (-)-preussin B over nine steps, and 7% for (+)

173 metric syntheses of (+)-preussin B, the C(2)-epimer of (-)-preussin B, and 3-deoxy-(+)-preussin B hav

174 atives, N-thioglycolyl-D-glucosamine (7, C-4 epimer of 1), and alpha-O-benzyl 2-acetamido-2-deoxy-D-g

175 energies of reactions leading to either C17 epimer of 13.

176 ith benzoyl-CoA to form predominantly one 3'-epimer of 2'-deoxytaxol.

177 The non-naturally occurring 20R epimer of 20-hydroxyvitamin D3 is synthesized based on c

178 Chromatographic resolution of the 3-epimer of 25(OH)D(3) proved to be essential for accurate

179 o known as megalin) with 25(OH)D3 and the C3 epimer of 25(OH)D3 [3-epi-25(OH)D3]; cubilin (CUBN) with

180 mation of one covalent adduct (cis-isomer, S-epimer of [TAM]G) formed from the reaction of tamoxifen

181 The C-2 epimer of aceric acid was also synthesized using thiazol

182 of ursodeoxycholic acid, the 7 beta-hydroxy epimer of chenodeoxycholic acid, was investigated in thr

183 yxose (Lyx), rarely found in biology, but an epimer of D-arabinose, a key component of the mycobacter

184 An epimer of dG-N2-trans-TAM showed targeted mutations rang

185 The 4'-epimer of doxorubicin, epidoxorubicin, reacts with forma

186 phosphorylation of d-glucuronic acid, the 4-epimer of GalA.

187 D-mannose, a C-2 epimer of glucose, exists naturally in many plants and f

188 s a member of the aldohexose family and a C3 epimer of glucose.

189 so accepts hapalindole A, a halogenated C-10 epimer of hapalindole U, and catalyzes normal prenylatio

190 A sample of the (4'R,4''S)-epimer of hopromine was also produced using this approac

191 applied to the smooth preparation of the 11R-epimer of ipomoeassin F for the first time.

192 Erythorbic acid, an epimer of L-ascorbic acid, is used in the United States

193 new natural product was determined to be an epimer of latrunculin B (1), which was found in the same

194 xide to methionine and is specific for the S epimer of methionine sulfoxide.

195 D-chiro-Inositol is an epimer of myo-inositol that is found in certain mammalia

196 al injection of 2.5 micrograms of the 3 beta-epimer of pregnanolone did not affect behavior in the pl

197 a-5Z,7E,9E,13Z,15E,19Z-hexaenoic acid, a 17R-epimer of RvD3, for in vivo experiments.

198 ypothesis, the reaction of DesII with the C4-epimer of TDP-quinovose (TDP-fucose) was examined.

199 c acid (ursodiol), a naturally occurring 7-B-epimer of the bile component chenodeoxycholic acid, for

200 n, and the minor adduct was identified as an epimer of the cis form.

201 synthesis of frondosin B led to the opposite epimer of the natural product, suggesting an unusual lat

202 th a 3-5 kcal/mol preference for the C5-beta epimer of the ring-closed cation.

203 uct was identified chromatographically as an epimer of the trans form of alpha-(N2-deoxyguanosinyl)ta

204 antaginaceae family) are derived from the C7 epimer of this scaffold.

205 The methyl ester of the 3'-epimer of thymidylic acid 9 was also prepared from thymi

206 modified oligodeoxynucleotides containing an epimer of trans- and cis-forms of dG-N2-tamoxifens were

207 The 3-alpha(axial)-epimer of ursolic acid suppressed de novo formation of C

208 syntheses of (-)-hyacinthacine B4 and of two epimers of (+)-hyacinthacine C5, allowing a suggestion o

209 Thus, the corresponding epimers of (S(S),S)-2-substituted pyrrolidines were synt

210 Alginates are linear chains of epimers of 1,4-linked uronic acids, beta-D-mannuronic ac

211 The C(23) epimers of 1alpha,23,25(OH)3-24-oxovitamin D3, a major n

212 nd 3-O-galactosides) were separated by TIMS, epimers of 3-O-pentosides assessed could not be distingu

213 e, providing access to either alpha- or beta-epimers of 4-acetylpyrrolidine depending on the reaction

214 led to a separable mixture of (4R)- and (4S)-epimers of 4-hydroxylysine, with protected amino groups

215 9alpha-Methyl-1alpha,25-(OH)2D3, both epimers of 9-methylene-10,19-dihydro-1alpha,25-(OH)2D3 a

216 Epimers of D-galactose at C-3 (D-gulose) and C-4 (D-gluc

217 In fact, the epimers of each of chol 4-OOH, 6-OOH, and 7-OOH are read

218 or product, cholesterol 7-hydroperoxide, the epimers of each of the regioisomeric 4- and 6-hydroperox

219 Three epimers of ethylene glycol bis(tropane-3-carboxylate) (3

220 so promotes the generation of a series of 15-epimers of LXA(4), known as aspirin-triggered lipoxins (

221 The epimers of the catechins showed similar inhibitory effec

222 ations of the acetamido substituents in both epimers of the final product were determined by NOESY NM

223 This route provided both C-13 epimers of the macrolactone by using either enantiomeric

224 In addition to the epimers of the major product, cholesterol 7-hydroperoxid

225 UDP-glucose or the galactose epimers of the normal substrates did not substitute.

226 The total synthesis of both side chain epimers of the originally reported structure of circuloc

227 are affected by stereochemistry, since five epimers of the pentapeptide, H2N-Gly-Leu-Ser-Phe-Ala-OH

228 both compounds was confirmed by synthesizing epimers of the proposed structures.

229 ution by triggering biosynthesis of specific epimers of these mediators.

230 ations to investigate how two diastereomers (epimers) of dihydrofuroaporphine bind to the serotonin 5

231 distinct sets of Abeta17-28 tryptic peptide epimers on a rapid (~1 s) time scale.

232 , distinguishing, for example, between sugar epimers or structurally similar anions.

233 n, an energetic preference for the unnatural epimer over the natural epimer, and a slower overall rat

234 was obtained as a 7:1 mixture of (expected) epimers owing to the configuration of the 13(2)-carbomet

235 on mobility spectrometry can distinguish the epimer pair in under 30 ms due to the presence of a uniq

236 pylidene-alpha-D-xylofuranose 9 for the 9:10 epimer pair, and equatorial 1-deoxy-1-pyridyldimethylgly

237 ylidene- alpha-D-glucofuranose 4 for the 4:5 epimer pair, exo-3-deoxy-3-pyridyldimethylglyoximatocoba

238 enzyl-beta-D-gl ucopyranose 12 for the 12:13 epimer pair.

239 the 7:3 cis-(5R,6S):trans-(5R,6R) mixture of epimers paired opposite adenine in the 5'-GTgG-3' sequen

240 ynthesis of (-)-podophyllotoxin and its C(2)-epimer, (-)-picropodophyllin.

241 The solvolysis of the endo epimer presents a more complex picture, reacting via a c

242 ore significantly, EDD of HS tetrasaccharide epimers produces diagnostic product ions that can be use

243 Budesonide epimer R (BUDeR) and dexamethasone (DEX) were studied as

244 owth medium as early as 1 h after budesonide epimer R treatment.

245 methasone and, in particular, the budesonide epimer R were shown to effectively and rapidly induce tr

246 sing haptophilicity, assessed as the product epimer ratio, for the groups studied was R = CH(2)NH(2),

247 hase sodiated conformer, not shared with the epimer, reducing the need for chromatographic separation

248 s-5R,6S epimer; the level of the trans-5R,6R epimer remained below the level of detection by NMR.

249 In contrast, the antagonist epimer remained firmly stabilized in the binding pocket.

250 imes that of the noncharged form for the two epimers, respectively.

251 and computational investigation of the alpha-epimer revealed that the 4'-OMe imparts a conformational

252 the RvD2 receptor and was equipotent to its epimer RvD2.17R-RvD2 also significantly increased phagoc

253 These epimer-sensitive fragmentations should allow this approa

254 eline SLIM SUPER IM resolution for all Abeta epimer sets assessed, while such baseline separations we

255 ursue the tedanolide synthesis via C(15)-(S)-epimers, since this stereochemical change would destabil

256 Although ion mobility separates the epimers, some chromatography is required to separate com

257 ly separating all 18 pairs of representative epimer species with masses of ~400-5,000 Da and charge s

258 PKSs support that C2-type KRs cooperate with epimer-specific ketosynthases to set the configurations

259 long with synthetic elaboration to their C14-epimers starting from d-glucose using beta-glycosylation

260 For the cis-(5R, 6S) epimer Tg and A are inserted into the helix, remaining i

261 threonine (Thr) as well as their side chain epimers (the allo counterparts).

262 l antibacterial assays reveal that both C-22 epimers (the N-glycosidic linkage) of the natural produc

263 To avoid costly fractionation of the epimer, the enzyme was evolved to invert stereoselectivi

264 pectra in D(2)O for pairs of unprotected C-4 epimers, the spectra were recorded at approximately the

265 rans-5R,6R equilibrium favored the cis-5R,6S epimer; the level of the trans-5R,6R epimer remained bel

266 s a mixture of cis-(5R,6S) and trans-(5R,6R) epimers; these modulate base excision repair.

267 ported synthesis of the corresponding 1 beta-epimers, thus producing all stereoisomers of these versa

268 equent C-4 keto reduction of the resulting L-epimer to give GDP-L-colitose.

269 ntrast, its homologue DdahC only uses the C3 epimer to yield d-altro-heptose via C4 reduction.

270 Compared with its epimer trans-WOOH and H(2)O(2), cis-WOOH reacts slower w

271 For each epimer, variable-temperature NMR experiments, including

272 This provided largazole along with its C2-epimer via an unexpected inversion of the alpha-stereoce

273 the D-isoform are distinguished from their L-epimers via differences in the relative amounts of speci

274 unnelling (RT) can classify many anomers and epimers via the current fluctuations they produce when c

275 as an "all-R" stereoisomer mixed with its 3S-epimer was confirmed.

276 The C4'alpha epimer was synthesized by a stereoselective route in six

277 total synthesis of berkelic acid and its C22 epimer was thus completed in a 10 step linear sequence a

278 e equilibrium ratio of cis-5R,6S:trans-5R,6R epimers was 7:3 for the duplex containing the Tg(6) x A

279 guration at the beta-position (i.e. its beta-epimer)) was produced only in the LigF-catalyzed reactio

280 smethyl-25,26-dihydrodictyostatin and its C6 epimer were chosen as potentially potent yet accessible

281 apoptosis assays on ipomoeassin F and/or its epimer were conducted.

282 The spectroscopic data of these epimers were in complete agreement with those for the na

283 ecificity for its substrates where 1 beta(R)-epimers were preferred to 1 alpha(S)-epimers, although i

284 Briefly, the d/l-peptide epimers were separated by online reversed-phase liquid c

285 ations of both 20S,23S/R-dihydroxyvitamin D3 epimers were unambiguously assigned by NMR and Mosher es

286 These epimers were unexpected based on the belief that tea PAs

287 nal isomers), and uronic acid epimerization (epimers) were separated and sequenced.

288 dihydroxy-2-methylenevitamin D3 and its C-20 epimer, were found to be almost as active as 2-methylene

289 on is diastereoselective, in favor of the 1S epimer, when large groups are attached to the phenyl rin

290 beta-S-glutathionyl-alpha-veratrylglycerone) epimers, whereas the other diastereomer (differing in co

291 hiles is base sensitive and might afford two epimers which differ at one chirality center.

292 rein, we studied the pharmacodynamics of HHC epimers, which activate CB1R.

293 osaccharide building blocks are often simple epimers, which when combined produce diastereomeric glyc

294 h more active in vivo than the corresponding epimers with 2beta-configuration.

295 tegy was demonstrated by analysis of peptide epimers with different molecular sizes, [d-Trp]-melanocy

296 hile being capable of utilizing two distinct epimers with the same efficiency to generate five distin

297 ar IMS and FAIMS previously disentangled d/l epimers with up to ~30 residues.

298 e (3'R)-10 diastereomer and a set of related epimers, with the goal of defining the stereochemical ro

299 ds, concanavalin A discriminated between C-2 epimers, with the manno configuration binding more tight

300 eric 2,2-diaryl-cis-4,6-dimethyl-1,3-dioxane epimers, X-ray crystallography, (1)H NOESY analysis, and