ライフサイエンスコーパス: epimerization

1 ch cascade followed by in situ oxidation and epimerization.

2 r precursor peptide confirmed the absence of epimerization.

3 bon center that could be considered prone to epimerization.

4 MDOs for the tandem reaction and an ensuing epimerization.

5 ed insights into the mechanism of reversible epimerization.

6 ethyl substituent had undergone KR-catalyzed epimerization.

7 on with nitrous acid retains the uronic acid epimerization.

8 ylation modifications as well as uronic acid epimerization.

9 sible "ionogenic conducted tour" pathway for epimerization.

10 wever, destroy information about uronic acid epimerization.

11 s glycopeptides with high efficiency and low epimerization.

12 AG depolymerization that retains uronic acid epimerization.

13 wing group at position 5 slows oxidation and epimerization.

14 sulfation pattern as well as the uronic acid epimerization.

15 et-Spengler reaction, and H(2)SO(4)-mediated epimerization.

16 about the sulfation pattern and uronic acid epimerization.

17 e in enzyme activity while minimizing GlcNAc epimerization.

18 n, N-sulfation, O-sulfation, and uronic acid epimerization.

19 of most peptide side chains and with minimal epimerization.

20 dic conditions (0.5 M HCl/EtOAc) to minimize epimerization.

21 molybdate-saccharide reactive complex during epimerization.

22 ated competing pathway involving GDP-glucose epimerization.

23 ositions of GalNAc sulfation and uronic acid epimerization.

24 sidues in a variety of ways, one of which is epimerization.

25 fering in sulfation position and uronic acid epimerization.

26 oove in AlgG contains the catalytic face for epimerization.

27 imarily direct fragmentation and secondarily epimerization.

28 analysis of cycloadducts not susceptible to epimerization.

29 of the glycolic acid residue followed by C12 epimerization.

30 de from moderate to excellent yields without epimerization.

31 r the controlled ROP of various OCAs without epimerization.

32 -piperidine)s H syntheses were vulnerable to epimerization.

33 and attenuates coordination-promoted product epimerization.

34 ulates the resultant alpha-stereocenter from epimerization.

35 anes take place primarily through one-center epimerizations.

36 s previously been implicated in KR-catalyzed epimerizations.

37 ously unknown biosynthetic steps including 6-epimerization, 6,8-dehydration, 4-epimerization, and 6-t

38 MlghB forms three products via C3 and C5 epimerization activities, whereas its DdahB homologue on

39 imerization activity and that Cjj1427 has no epimerization activity and only serves as a reductase to

40 Cjj1430 serves as C3 epimerase devoid of C5 epimerization activity and that Cjj1427 has no epimeriza

41 protein expressed in Escherichia coli showed epimerization activity toward substrates generated from

42 e 19 chiral amino acids but exhibited strong epimerization activity with hydroxyproline as the substr

43 the proposed monomer-assisted, catalyst-site epimerization, after an enantiofacial mistake, to a ther

44 Successful base-induced epimerization alpha to the carbonyl of the anti-7-ethoxy

45 ation of factors, including a faster rate of epimerization, an energetic preference for the unnatural

46 osan (-GlcA(1,4)GlcNS-); enzyme-catalyzed C5-epimerization and 2-O-sulfonation leading to undersulfat

47 Both epimerization and 5'-hydrogen exchange reactions are sti

48 Subsequent alpha-epimerization and alpha-alkylation or acylation led to t

49 merization, was severely inhibited by serine epimerization and altered by isomerization of nearby alp

50 e manifest in the two distinct reactions, C5-epimerization and C2/3-desaturation.

51 The epimerization and chiral resolution of 27c followed by f

52 or cultivation of mayapple and semisynthetic epimerization and demethylation of podophyllotoxin.

53 e responsible for the terminal reactions, C5 epimerization and desaturation, in simple carbapenem pro

54 The epimerization and enantioselective polymerization can be

55 its 8-endo epimer 1b experience appreciable epimerization and fragmentation.

56 g the [1,3] shift are significant amounts of epimerization and fragmentation.

57 SDRs lead to substantially altered RS to RR epimerization and ODL-reduction activities.

58 ed in this process, particularly issues with epimerization and slow coupling rates, and methods to ov

59 Variations in HS epimerization and sulfation provide enormous structural

60 ycosidic bond between the residue undergoing epimerization and the adjacent residue.

61 ncluding 6-epimerization, 6,8-dehydration, 4-epimerization, and 6-transamination that convert GDP-D-e

62 rt the synthesis, unexpected light-driven di-epimerization, and activity-based protein profiling of a

63 Mass balance, epimerization, and aqueous-phase degradation (i.e., hydr

64 ate constants and barriers of isomerization, epimerization, and enantiomerization processes occurring

65 ts synthesis, pK(a), rates of acid-catalyzed epimerization, and enzymatic incorporation.

66 acetylation, chemical N-sulfation, enzymatic epimerization, and enzymatic sulfation with recombinant

67 rule out any role for the NADPH cofactor in epimerization, and provide a general experimental basis

68 functional switch of E1 toward dehydration, epimerization, and transamination.

69 intermediate is the operative catalyst when epimerizations are initiated with amines with pK(a) 7.4

70 in]-2(1H)-one scaffold that are not prone to epimerization as observed for the initial spiro[3H-indol

71 ive glucosylation followed by gluco to manno epimerization at a late stage of the synthetic pathway.

72 g could not be opened hydrolytically without epimerization at C alpha.

73 Epimerization at C-1 took place under acidic conditions

74 o UDP-GalNAc, followed by the TviC-catalyzed epimerization at C-4 to form UDP-GalNAcA, which serves a

75 tecone (6) shows a biogenetically intriguing epimerization at C14.

76 1,8-diazabicyclo[5.4.0]undec-7-ene mediated epimerization at C2 of the pyrrolidine core.

77 ly of the ethyl side chain at C6, bridgehead epimerization at C5, installation of the C2-thioether si

78 seldom-used Wharton rearrangement, and a key epimerization at C5.

79 s initiated by C1-C6 bond cleavage are seen, epimerization at C8 is much faster than [1,3] shifts lea

80 t thermal isomerization process, however, is epimerization at C8 to afford product 3.

81 reoselectivity; the intermediate can undergo epimerization at iridium before being trapped by halide

82 to establish the timing and mechanism of the epimerization at methyl-bearing centers, a series of inc

83 Slow epimerization at phosphorus may occur by inversion but m

84 risidine are also synthesized, which undergo epimerization at room temperature in the presence of aqu

85 ycopeptides result in substantial amounts of epimerization at the alpha position.

86 igh yield although the products are prone to epimerization at the alpha-position in the presence of t

87 prepared from protected (S)-lactals without epimerization at the alpha-stereocenter.

88 Processes related to chain transfer and site epimerization at the metal center are also reported.

89 The opening takes place without epimerization at the secondary stereocenter.

90 vatives were obtained in good yields without epimerization at the stereogenic center.

91 An unexpected pair of consecutive epimerizations at two contiguous stereocenters is observ

92 MR analysis, we show that PelX catalyzes the epimerization between UDP-GlcNAc and UDP-GalNAc.

93 Furthermore, kinetic parameters for ion pair epimerization by cocatalyst exchange (ce) and anion exch

94 alpha-Epimerization by oxidation and diastereoselective reduct

95 trogen atoms and enables a selective alcohol epimerization by stepwise or reversible oxidation and re

96 s D-L-L-L-tetrapeptidyl-S-T(4) after in situ epimerization by the E domain.

97 determination of the interconversion rates (epimerization) by 1D 1H EXSY spectroscopy in C6D6 soluti

98 oceeds by a Michael/Michael/cyclopropanation/epimerization cascade in which size and coordination of

99 During this epimerization, cationic palladium alkyls 13/14 and 33 an

100 length, sulfate content, and glucuronic acid epimerization content, resulting in a distribution of gl

101 fold diversification involves hydrogenation, epimerization, dehydration, and condensation of the carb

102 Analysis of the rate of epimerization demonstrated first-order kinetics with res

103 Under these optimized conditions, epimerization did not occur at the alpha carbons of alph

104 formed in situ from their L-stereoisomers by epimerization domains or dual-function condensation/epim

105 zation domains or dual-function condensation/epimerization domains.

106 ion products were detected and the extent of epimerization during cocoa roasting was shown to be a fu

107 of peptide folding but are prone to alpha-C epimerization during Fmoc solid-phase peptide synthesis.

108 hile the stereoinversion is catalyzed by the epimerization (E) domain, the terminal condensation (C)

109 L-enantiomers through the action of integral epimerization (E) domains of an NRPS.

110 ne motor can be thermally inverted, and this epimerization enables a "shortcut" of the traditional ro

111 assay for FabA, the bifunctional dehydration/epimerization enzyme and key target in the FASII pathway

112 sulfate positional isomers), and uronic acid epimerization (epimers) were separated and sequenced.

113 f a proton from C5 of the residue undergoing epimerization followed by re-protonation on the opposite

114 n (re-formation of C1-C8 with or without net epimerization, fragmentation to 1,3-cyclohexadiene and e

115 We describe here the epimerization-free synthesis and characterization of a n

116 D-phenylalanine at position 44, and that the epimerization from an L-Phe to a D-Phe has a dramatic ef

117 produced the trans cyclohexenone, which upon epimerization gave the more stable cis enone 18.

118 he AB ring system nearly free of competitive epimerization (>30:1 dr), and two room-temperature atrop

119 tates can be used with minimal to negligible epimerization in a variety of canonical Ugi four-compone

120 ain highlighting the potential importance of epimerization in flavan-3-ol biosynthesis.

121 e ligations are conducted with minimal alpha-epimerization in the C-terminal group and allow for the

122 atch protecting group for the suppression of epimerization in the O-alkylation and reductive aminatio

123 number of mechanistic studies indicate that epimerization in these systems occurs via a Lewis acid c

124 However, the C-5 center was prone to epimerization in vitro and in vivo, forming a less poten

125 hat catalyze deacetylations, sulfations, and epimerizations in specific positions of the sugar residu

126 Numerous sites of isomerization and epimerization, including several that have not been prev

127 Carbohydrate epimerization is an essential technology for the widespr

128 uctase domain supports the proposal that the epimerization is catalyzed by the ketoreductase domain i

129 mulated by the allosteric effector dGTP, and epimerization is not detected in the absence of the effe

130 rst-generation Hoveyda catalyst is employed, epimerization is observed only if an additional phosphin

131 The structural and mechanistic basis of epimerization is poorly understood, and only a small num

132 substrate preference for IdoA over GlcA, C5-epimerization is required for normal HS sulfation.

133 Thus, the barrier to site epimerization is very low and high polymerization rates

134 um) and base (pseudobase), the rate of these epimerizations is sensitive to steric bulk in the pyryli

135 ion (o-succinylbenzoate synthase; OSBS), and epimerization (L-Ala-D/L-Glu epimerase).

136 p was added to the C-5 position to eliminate epimerization, leading to the discovery of (S)-2-((1S,2S

137 change on the microsecond time scale, (b) C5 epimerization leads to a (4)C(1)-chair, and (c) IdoA 2-O

138 ubsequent suprafacial 1,4-hydrogen shift and epimerization leads to the observed cis-fused products.

139 The epimerization mechanism has been elucidated through a se

140 ments provided insight into the cis to trans epimerization mechanism involved in the Pictet-Spengler

141 They iteratively catalyse epimerization, methylation and hydroxylation of diverse

142 Furthermore, we find that spontaneous epimerization, necessary to correct the configuration at

143 The results suggest that a late-stage epimerization, not a failure of an asymmetric synthesis

144 Fourth, no epimerization occurs at the vulnerable alpha-chiral cent

145 to BOC-protected phenylalanine methyl ester, epimerization occurs so that the use of a more reactive

146 unselective C-H arylation reaction, a slower epimerization occurs to provide the high diastereomer ra

147 Because anomeric epimerization occurs under these conditions, C-glycoside

148 nol losses and modifications, especially the epimerization of (-)-epicatechin to (-)-catechin.

149 r pathway was ruled out for the cis to trans epimerization of 1,2,3-trisubstituted 1,2,3,4-tetrahydro

150 In an attempt to suppress the epimerization of 2 without losing activity against the H

151 The fourth step involves epimerization of 5-keto-l-gluconate to d-tagaturonate by

152 a prochiral bis-hydroxymethyl group with the epimerization of a chiral furanyl ether in a single tran

153 In this study we followed the epimerization of a chiral Grignard reagent, prepared by

154 The key synthetic steps involve an epimerization of a cis-5-oxodecahydroquinoline to the co

155 f sodium tetraborate catalyses the selective epimerization of aldoses in aqueous media.

156 g sulfations of distinct hydroxyl groups and epimerization of an asymmetric carbon atom.

157 This method relies on the epimerization of an NHC-enol intermediate before subsequ

158 r example, isomerization of aspartic acid or epimerization of any chiral residue within a peptide do

159 These epimerases are responsible for the epimerization of beta-D-mannuronic acid (M) to alpha-L-g

160 The key step of this approach is an epimerization of C5 by an elimination-addition sequence

161 In all cases studied, epimerization of chlorophosphonium chlorides has a lower

162 rtaken to shed light on the mechanism of the epimerization of cis-1,2,3-trisubstituted tetrahydro-bet

163 One of the modification reactions is the epimerization of D-glucuronic acid to its C5-epimer L-id

164 00294, a previously orphan EC number; and 3) epimerization of d-tagatose 6-phosphate C-4 to d-fructos

165 get DprE1, an oxidoreductase involved in the epimerization of decaprenyl-phosphoribose (DPR) to decap

166 itional step appears to be necessary for the epimerization of DHMP to DHNP.

167 The E. coli FolB protein also mediates epimerization of DHN to 7,8-dihydromonapterin.

168 hydroxymethyl-7,8-dihydropterin (HP) and the epimerization of DHNP to 7,8-dihydromonopterin (DHMP).

169 hese AEGIS components, verify the absence of epimerization of dZ in those oligonucleotides, and repor

170 Epimerization of epiaristolochen-3-one (27a) at the C4 m

171 During the irradiation of 3-benzoyl estrone, epimerization of estrone through the Norrish type I reac

172 is a bifunctional enzyme catalyzing the C-5 epimerization of GDP-4-keto-3,6-dideoxy-D-mannose and th

173 glucuronyl C5-epimerase (Hsepi) catalyzes C5-epimerization of glucuronic acid (GlcA), converting it t

174 htly controlled, cell-specific sulfation and epimerization of HS precursors endows these chains with

175 l centers such as dl-Ile or dl-Thr, only the epimerization of isomers with different stereochemistry

176 diates both the effectively complete L- to D-epimerization of its C-terminal amino acid residue (>=10

177 trapped by halide and can also catalyze the epimerization of kinetic diastereomer product to thermod

178 The epimerization of l-talarate to galactarate that competes

179 dition reaction intermediate involved in the epimerization of lobeline is described.

180 pairs have been discovered to catalyze rapid epimerization of meso-lactide (LA) or LA diastereomers q

181 eparation artifacts caused by base-catalyzed epimerization of N-acetylglucosamine (GlcNAc) at the red

182 Epimerization of O4 afforded the galactosamine derivativ

183 On the other hand, epimerization of ortho-regioisomer 2-acetyl estrone occu

184 We illustrate that isomerization and epimerization of peptides can be identified in this fash

185 in vivo via the IsoP pathway, presumably by epimerization of racemic 15-E2t-IsoP and 15-D2c-IsoP, re

186 ansfer (HAT) approach for the light-mediated epimerization of readily accessible piperidines to provi

187 d NV10129 that are capable of catalyzing the epimerization of RS to RR via (4R)-5-oxo-4-decanolide (O

188 Specifically, epimerization of serine (alphaASer-162) dramatically wea

189 impact of isomerization of aspartic acid or epimerization of serine at four sites mapping to crucial

190 The reactions proceed without epimerization of stereogenic centers in the peptide chai

191 ion in the hexuronic acid catabolic pathway, epimerization of tagaturonate to fructuronate.

192 n was stereochemically scrambled, leading to epimerization of the (5'S)-[5'-(2)H(1)]- and (5'R)-[5'-(

193 rotein (ACP) substrates and in certain cases epimerization of the 2-methyl group as well.

194 Epimerization of the 7'a bridgehead carbon under acidic

195 presence of RhCl(3) is achieved without any epimerization of the acid/base labile stereogenic center

196 A stereoselective epimerization of the aldehyde-containing stereocenter wa

197 alpha-Epimerization of the alkaloid ketones resulted in format

198 ylaminopyridine (DMAP), may induce undesired epimerization of the alpha-carbon atom in polyesters res

199 ubstitution was demonstrated in principle by epimerization of the alpha-diastereomer and kinetic dias

200 he-Cys-OMe model tripeptide revealed minimal epimerization of the C-terminal cysteine residue under b

201 roduct distribution changes over time due to epimerization of the C1 center.

202 ro molecule through controlled oxidation and epimerization of the C13 spirocenter under mild acidic c

203 RmlC catalyzes the epimerization of the C3' and C5' positions of dTDP-6-deo

204 nsights of potential generality, such as the epimerization of the cis-isomer to the thermodynamically

205 synthesized and employed to investigate how epimerization of the citric acid moiety or imide formati

206 Epimerization of the citric acid stereocenter perturbed

207 rates of nucleophilic attack to the rates of epimerization of the diastereomeric allyliridium complex

208 Facile metal-centered epimerization of the dormant species is responsible for

209 glucuronyl C5-epimerase (Glce) catalyzes C5-epimerization of the HS component, d-glucuronic acid (Gl

210 The rates of epimerization of the less thermodynamically stable diast

211 Epimerization of the N-acetyl-glucosamine residues to N-

212 The unique epimerization of the P-chiral center of the undesired (R

213 emely facile, atom-economical method for the epimerization of the product mixture to the trans isomer

214 al, epoxidation followed by cyclization, and epimerization of the ring fusion.

215 with various silylated nucleophiles without epimerization of the stereogenic center, giving access t

216 er by N- and O-sulfation, N-acetylation, and epimerization of the uronic acid.

217 high heterogeneity of modifications, and the epimerization of the uronic acids.

218 acid due to poor solubility and/or to avoid epimerization of this residue.

219 zed enzyme of unknown function (PDB 2PMQ), 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp

220 ains catalyze the biosynthetically essential epimerization of transient (2R)-2-methyl-3-ketoacyl-ACP

221 from 3b, as a result of EryKR3(0)-catalyzed epimerization of transiently generated [2-(2)H]-2-methyl

222 lated to proceed with or without consecutive epimerization of two alpha-carbanions.

223 UDP-GlcA 4-epimerase (UGlcAE) catalyzes the epimerization of UDP-alpha-D-glucuronic acid (UDP-GlcA)

224 f this sugar, is known to be formed by the 4-epimerization of UDP-D-glucuronate; however, no coding r

225 ia pastoris indicate that it catalyzes the 4-epimerization of UDP-D-Xyl to UDP-L-Ara, the nucleotide

226 aterial because of a partial defect in the 4-epimerization of UDP-D-Xyl to UDP-L-Ara.

227 that Gne is slightly more efficient for the epimerization of UDP-GalNAc and UDP-Gal.

228 GlcNAc inhibits CS synthesis by inhibiting 4-epimerization of UDP-GlcNAc to UDP-GalNAc, thereby deple

229 The MMP0705 protein catalyzed the C-2 epimerization of UDP-GlcNAc, and the MMP0706 protein use

230 osynthesis of UDP-Arap mainly occurs via the epimerization of UDP-xylose (UDP-Xyl) in the Golgi lumen

231 the four possible products occurs due to the epimerization of unreactive intermediates from the other

232 A novel ruthenium carbene-catalyzed epimerization of vinylcyclopropanes is reported.

233 Evidence for C3 epimerization of Weinreb amide structures via a nonbasic

234 , including sulfations of sugar residues and epimerizations of their glucuronic acid moieties.

235 datory deaggregation (or aggregation) on the epimerization path.

236 n, chain length, sulfation, acetylation, and epimerization patterns.

237 re concerned, their relatively rapid rate of epimerization precluded this.

238 er would require ANR but not LCR and that an epimerization process is involved.

239 The understanding of this epimerization process is of importance when Pictet-Speng

240 osed to operate as a racemase, aiding in the epimerization process that reverses the orientation of t

241 To learn more about the epimerization process, the structure of the C2-type KR f

242 tep in the carbocation-mediated cis to trans epimerization process.

243 Racemization and epimerization processes are often observed for the title

244 c amounts of Sn-Beta yields near-equilibrium epimerization product distributions.

245 rried out the aldol cleavage reaction on the epimerization product, 7,8-dihydromonapterin, as well as

246 Five dimeric and two trimeric potential epimerization products were detected and the extent of e

247 ucible stereoisomerization (racemization and epimerization) protocol for the preparation of scalemic

248 alyzed by the conjugate acid of His 328) and epimerization (protonation on C2 by the conjugate acid o

249 Epimerization rate constants k(tc) were determined at 19

250 oluene reveals an estimated ordering in site epimerization rates as 5 > 4 > 2 > 3 > 6, while product

251 The epimerization reaction catalyzed by a member of PF08013

252 Since the epimerization reaction had been shown to be sensitive to

253 In addition, an atypical epimerization reaction is described.

254 strate the essential role of Lys(66) for the epimerization reaction with participation of neighboring

255 first report of a flavoprotein catalyzing an epimerization reaction.

256 sidue form as transient intermediates in the epimerization reaction.

257 ned using the same strategy preceded by a C1 epimerization reaction.

258 xes along with mechanistic insights into the epimerization reactions and their applications in cataly

259 rom Bifidobacterium longum (bGalE) catalyzes epimerization reactions of UDP-Gal into UDP-Glc and UDP-

260 (+)-epicatechin and (-)-catechin due to the epimerization reactions produced in chocolate manufactur

261 biomass carbohydrates through site-selective epimerization reactions.

262 ering the opportunity to lower the degree of epimerization, reduce the dose of coadministered booster

263 ic studies, we demonstrate that the enhanced epimerization relative to nonglycosylated amino acids is

264 rity enabled by A(1,3)-strain rendering slow epimerization relative to the rate of bis-cyclization.

265 owever, the physiological significance of C5-epimerization remains elusive.

266 In fact, epimerization resulted in up to 80% of the non-natural e

267 e nitrile undergoes a kinetically controlled epimerization/ saponification to afford the pure trans-p

268 rates of undesirable transesterification and epimerization side reactions at high conversion in the c

269 ppresses undesirable transesterification and epimerization side reactions, preserving the integrity o

270 olymerization without transesterification or epimerization side reactions.

271 quirement of N-sulfate groups vicinal to the epimerization site for substrate binding.

272 At the epimerization site, the GlcA/IdoA rings are highly const

273 us SnoN (38% sequence identity) catalyzes an epimerization step at the adjacent C4'' carbon, most lik

274 nthetic route relying on a key base-promoted epimerization step to synthesize two series of activity-

275 Reported herein is a convenient epimerization strategy that provides direct access to a

276 N-alkyl and aryl derivatives were effective epimerization substrates.

277 RiboZ is more stable against epimerization than its 2'-deoxyribo analogue.

278 a general method of performing carbohydrate epimerizations that surmounts the main disadvantages of

279 o understand the molecular basis of alginate epimerization, the structure of Pseudomonas syringae Alg

280 period of 30-90 days, it underwent complete epimerization to exclusively deliver the desired natural

281 on of l-talarate is accompanied by competing epimerization to galactarate; little epimerization to l-

282 mpeting epimerization to galactarate; little epimerization to l-talarate is observed in the dehydrati

283 ormation of the dipeptide is followed by C3'-epimerization to produce SB-217452 with the d-xylo confi

284 ide chain, GalNAzMe is not interconverted by epimerization to the corresponding N-acetylglucosamine a

285 is-3-hydroxy-l-proline (c3LHyp), competing 2-epimerization to trans-3-hydroxy-d-proline (1,1-proton t

286 domains (e.g., methylation, cyclization, and epimerization) to increase the complexity of the mature

287 Observation of quaternary carbon epimerization via a retro-Mannich/Mannich sequence highl

288 ative to reaction at 0.12 M Et2O in toluene, epimerization was 26-, 800-, and 1300-fold faster in Et2

289 ssion of undesirable transesterification and epimerization was achieved even with sterically unhinder

290 the 1,N2-dG cyclic adduct although transient epimerization was detected by trapping with the peptide

291 The energy barrier of epimerization was measured, suggesting that no intramole

292 C-Terminal epimerization was not observed.

293 The mechanism of the acid-promoted epimerization was studied in detail.

294 arying in sulfation patterns and uronic acid epimerization were analyzed by chemical derivatization a

295 The origins of this epimerization were determined, then the study was focuse

296 Proton abstraction and sugar epimerization were irreversible.

297 used, thereby establishing that methyl group epimerization, when it does occur, takes place after ket

298 l monomers to trimers, with special focus on epimerization, which was quantified for procyanidin dime

299 evolution approach that combines side-chain epimerization with backbone flexibility, we recapitulate

300 Observation of epimerization with mutated RTPR proves that transient cl