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1 hat it is involved in the restoration of the epithelial barrier.
2 ing in cytotoxicity and breakdown of the gut epithelial barrier.
3 e performed on skin biopsies to evaluate the epithelial barrier.
4 barrier integrity in AR, maintaining a leaky epithelial barrier.
5 romal lymphopoietin, IL-25, and IL-33 at the epithelial barrier.
6 ell-cell adhesion and a key regulator of the epithelial barrier.
7 s and supports maintenance of the intestinal epithelial barrier.
8 to act as an enterotoxin, disrupting the gut epithelial barrier.
9 regulation and maintenance of the intestinal epithelial barrier.
10 tional tension necessary to build an in vivo epithelial barrier.
11 adherin, resulting in the dysfunction of the epithelial barrier.
12 basal polarity and in the maintenance of the epithelial barrier.
13 , penetration efficiency was low across this epithelial barrier.
14 ACE2-expressing cells of the choroid plexus epithelial barrier.
15 free margin where they breached the weakened epithelial barrier.
16 the luminal milieu and the integrity of the epithelial barrier.
17 etion by M s, compromised the recovery of SI epithelial barrier.
18 uses and bacteria colonize hosts by invading epithelial barriers.
19 t gain access to sterile sites via disrupted epithelial barriers.
20 oles in regulating cationic gradients across epithelial barriers.
21 l microenvironments and drug-delivery across epithelial barriers.
22 mbrane tight-junction proteins that regulate epithelial barriers.
23 efore they can reach the underlying columnar epithelial barriers.
24 whereas type III IFNs act preferentially at epithelial barriers.
25 , (2) invasion of bacteria across the apical epithelial barrier, (3) nuclear factor-kappaB activation
26 f the immune system that function to protect epithelial barriers against pathogens and maintain tissu
27 te lymphoid cells (ILCs) function to protect epithelial barriers against pathogens and maintain tissu
28 upus erythematosus (LE) alters expression of epithelial barrier and adhesin genes, which, in turn, pr
29 by the production of toxins that disrupt the epithelial barrier and cause a robust host inflammatory
31 sbiosis, resulting in compromised intestinal epithelial barrier and chronic mucosal inflammation.
32 togenes employs to circumvent the intestinal epithelial barrier and compare and contrast these strate
34 COPD allows colonizing bacteria to cross the epithelial barrier and drive persistent inflammation and
36 and toxin B (TcdB), that damage the colonic epithelial barrier and induce inflammatory responses.
37 s a consequence of C. albicans breaching the epithelial barrier and invading surrounding tissues.
38 C-BMP can measure ABCC1 activity at the lung epithelial barrier and may be applicable in humans to as
40 ence that EoE is associated with an abnormal epithelial barrier and postulates that CS therapy, by re
43 ls are often implicated in the regulation of epithelial barrier and secretomotor functions of the int
44 ial cell activity in the acute regulation of epithelial barrier and secretomotor functions of the int
45 ity for disorders that involve a compromised epithelial barrier and suggest that targeting ATG9A may
46 ffect of miR-143 and miR-145 on the cervical epithelial barrier and to elucidate the mechanisms by wh
47 tic approach to support the integrity of the epithelial barrier and to protect from chronic colitis.
49 Epigenetic mechanisms could alter the airway epithelial barrier and ultimately lead to atopic disease
50 eolar surfactant, disruption of the alveolar epithelial barrier and, ultimately, lethal acute respira
53 receptor gamma T(+) regulatory T cells, the epithelial barrier, and healthy immunoglobulin A respons
54 ndida colonization, breach of the intestinal epithelial barrier, and venous translocation to organs.
56 play a role in the formation of the mucosal epithelial barrier, as it regulates the expression of th
58 regulated diet-microbiome-MHC class II-IL-10-epithelial barrier axis by circadian clock disarrangemen
59 s of cancer, including chronic inflammation, epithelial barrier breach, changes in cellular prolifera
60 miR-145 play a significant role in cervical epithelial barrier breakdown through diverse mechanisms
61 ral epithelial cells, which then impairs the epithelial barrier by inhibition of junction protein exp
62 duced phenotypic breakdown of the intestinal epithelial barrier caused by an increase in extracellula
63 in western diet (WD)-induced loss of colonic epithelial barrier (CEB) function in mice with a genetic
65 rect functional link between collecting duct epithelial barrier characteristics, which appear to prev
71 hat drive colitis in mice with an intestinal epithelial barrier defect and uncovered a surprising rol
73 inase inhibitor PP2 rescued cytokine-induced epithelial barrier defects and inhibited phosphorylation
74 different approaches to diagnose and target epithelial barrier defects are currently being developed
75 ew and discuss the current understandings of epithelial barrier defects in type 2-driven chronic infl
76 factorial, involving genetic predisposition, epithelial barrier defects, dysregulated immune response
77 s review, we discuss the individual roles of epithelial barrier defects, dysregulated innate and adap
79 n underlying and sustained susceptibility to epithelial barrier disruption upon removal from the micr
86 y available transcriptomes demonstrated that epithelial barrier dysfunction in asthma is characterize
87 ed investigations into mechanisms underlying epithelial barrier dysfunction in atopic dermatitis (AD)
91 induced architectural changes and esophageal epithelial barrier dysfunction through inhibition of the
92 rotein-1, on gamma-radiation-induced colonic epithelial barrier dysfunction using Caco-2 and m-IC(C12
93 ed IEC apoptosis, hyperproliferative crypts, epithelial barrier dysfunction, and chronic inflammation
94 and allergens leads to type 2 inflammation, epithelial barrier dysfunction, and difficulty in swallo
95 pods induce oxidative stress, inflammation, epithelial barrier dysfunction, and DNA damage in lung c
97 ologic function of TRAF2 that contributes to epithelial barrier dysfunction, which is attenuated by k
100 It is increasingly evident that a functional epithelial barrier engaged in intimate interplay with in
103 ted knockdown (KD) of ATG9A in IECs prevents epithelial barrier formation by >95% and results in sign
104 idate a role for mTORC1 in the regulation of epithelial barrier formation, cytoskeletal tension, and
106 participants, genes that promoted epidermal/epithelial barrier function (eg, filament-aggregating pr
107 if simulated microgravity alters intestinal epithelial barrier function (permeability), and suscepti
108 TLR5, IL-1R and CD11c+ cells in constitutive epithelial barrier function against P. aeruginosa, with
110 riasis lesions and included genes regulating epithelial barrier function and defense mechanisms, such
112 activity level of JNK signaling to maintain epithelial barrier function and host-microbe homeostasis
113 he PTPN2 gene variants compromise intestinal epithelial barrier function and increase the risk of inf
114 iated Caco-2 intestinal epithelium decreases epithelial barrier function and increases cation selecti
115 acrylic acid (IA), which promotes intestinal epithelial barrier function and mitigates inflammatory r
116 presented new approaches for improvement of epithelial barrier function and novel biologicals used i
117 el role of DRA in maintaining the intestinal epithelial barrier function and potential implications o
119 thway as a potential regulator of esophageal epithelial barrier function and suggest that downstream
120 ontrol subjects, including those involved in epithelial barrier function and type 2-associated inflam
124 ecessary and sufficient to diminish alveolar epithelial barrier function by impairing the ability of
126 important role in controlling the intestinal epithelial barrier function by serving as a precursor fo
128 effects of agents that compromise intestinal epithelial barrier function following return to Earth.
129 n is driven more by dysregulated allergy and epithelial barrier function genes, whereas the cause of
131 Loss of claudin-18 was sufficient to impair epithelial barrier function in 16HBE cells and in mouse
132 ts on the esophageal epithelium by impairing epithelial barrier function in association with loss of
133 equencing) of lungs and assessment of airway epithelial barrier function in ovalbumin-sensitized cont
135 of DEGs revealed that cellular assembly and epithelial barrier function in the proliferative phase a
136 This review focuses on the role of airway epithelial barrier function in the susceptibility to dev
137 n of NLRP3 by demonstrating that it protects epithelial barrier function independently of inflammasom
142 ypes of respiratory cells that will maintain epithelial barrier function once the capacity to regener
143 s that claudin-18 is a determinant of airway epithelial barrier function that is downregulated by IL-
144 d protein 1 (KRIT1) as a major regulator for epithelial barrier function through multiple mechanisms.
145 for the host colonic epithelium and enhance epithelial barrier function through unclear mechanisms.
146 and E-cadherin expression, and restored the epithelial barrier function to a nearly normal level.
147 (GI) (patho)physiology; from GI motility and epithelial barrier function to enteric neuroinflammation
148 test whether TLR2 or TLR3 stimulation alters epithelial barrier function using an in vitro model of h
149 alarm anti-protease, anti-microbial defense, epithelial barrier function, and epigenetic modification
150 tokine production cell-autonomously, impairs epithelial barrier function, and induces immune cell inf
151 ced changes in the intestinal immune system, epithelial barrier function, and other host features tha
152 CD73 deficiency led to a loss of endometrial epithelial barrier function, and pharmacological CD73 in
153 IF-1alpha-dependent claudin-1 expression and epithelial barrier function, as documented in 3D organot
154 of several bacterial pathogens which disrupt epithelial barrier function, damage cells and activate o
155 are involved in immunological regulation or epithelial barrier function, emphasizing the role of bot
156 These CpGs were in or near genes relevant to epithelial barrier function, including CDHR3 and CDH26,
157 t has been implicated in multiple aspects of epithelial barrier function, including regulation of epi
158 mice with a genetic impairment in intestinal epithelial barrier function, junctional adhesion molecul
159 tribute to the aforementioned maintenance of epithelial barrier function, nutrient absorption, and im
161 y of allergens and the latter with a role in epithelial barrier function, were DA in patients with SA
162 titis, have been associated with an impaired epithelial barrier function, which allows allergens, pol
163 HPV downregulated many genes involved in epithelial barrier function, which involves structural r
164 xis cytokine-IL-1beta-may transiently impair epithelial barrier function, while IL-1beta and IL-17 in
178 elial-mesenchymal transition and facilitated epithelial barrier functions by AJ localization of phosp
179 endent cellular processes, including loss of epithelial barrier functions, induction of apoptosis, an
183 m and a subsequent failure of the intestinal epithelial barrier have been shown to play essential rol
187 ting epithelial regeneration, which prolongs epithelial barrier impairment and creates an environment
188 a genetic basis for modulation of intestinal epithelial barrier in IBD, and we have identified MAGI3
190 s were published emphasizing the role of the epithelial barrier in patients with allergic diseases.
192 MSC-Ex recovered the destruction of the epithelial barrier in the differentiated Caco-2 cells in
193 1 plays a significant role in maintenance of epithelial barrier in the intestine via regulation of ap
195 microcirculation and subsequent crossing of epithelial barriers in mucosa-lined organs such as the l
197 es, and microplastic on the integrity of the epithelial barriers in the context of epithelial barrier
198 itive effects, such as in the maintenance of epithelial barriers in the gastrointestinal tract, but a
200 and proteins is prevented by the intestinal epithelial barrier, in which intercellular tight junctio
201 gene expression associated with the physical epithelial barrier, including keratinocyte cytoskeleton,
202 scuss the mechanisms that lead to intestinal epithelial barrier inflammation and the relevance of cer
203 ammatory cytokine response, disrupting colon epithelial barrier integrity and consequently limiting t
204 he disruption of gastrointestinal (GI) tract epithelial barrier integrity and subsequent microbial tr
205 to elucidate the impact of DRA deficiency on epithelial barrier integrity and to define underlying me
206 neutralization of IL-22 impaired intestinal epithelial barrier integrity and, consequently, exaggera
207 ke receptor (TLR) family of PRR may regulate epithelial barrier integrity by upregulating tight junct
209 sought to determine the role of oral mucosal epithelial barrier integrity in profilin-mediated allerg
210 c inflammatory mediators in modulating nasal epithelial barrier integrity in the pathophysiology in A
212 cascade, which begins with the disruption of epithelial barrier integrity through cleavage of E-cadhe
213 of USP48 increases E-cadherin expression and epithelial barrier integrity through reducing TRAF2 stab
214 al disorders pathogenesis to disturbances in epithelial barrier integrity, abnormal entero-endocrine
215 ic antiviral immunity, type III IFNs protect epithelial barrier integrity, an activity that would ben
216 e host-protective immune pathways related to epithelial barrier integrity, but can also induce reacti
217 ermine the consequences of EAEC adherence on epithelial barrier integrity, colonoid monolayers were e
218 ultimately results in compromised intestinal epithelial barrier integrity, further perpetuating intes
219 nses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic transl
220 in mouse myeloid cells caused impairment of epithelial barrier integrity, leading to high susceptibi
221 nizes the epithelial cell polarity, disturbs epithelial barrier integrity, promotes multiple invasion
222 transcription factor HIF-1alpha orchestrated epithelial barrier integrity, selectively controlling ti
223 of myeloid cell-IEC crosstalk in maintaining epithelial barrier integrity, suggesting that angiogenin
224 epithelial)-cadherin expression and enhances epithelial barrier integrity, while knockdown of USP48 a
231 oducing the nephrotoxin, Cyclosporine A, the epithelial barrier is disrupted in a dose-dependent mann
234 sue location, the homeostatic balance of the epithelial barrier is skewed toward loss of differentiat
236 ts reveal that the pressure developed across epithelial barriers is on the order of 100~300 Pa, and i
237 s a consequence of the disruption of the gut epithelial barrier, leading to the translocation of gut
238 Viral persistence drove sustained intestinal epithelial barrier leakage, which was characterized by i
243 These data indicate that KRIT1 controls epithelial barrier maintenance and regulation through mu
245 However, the molecular processes regulating epithelial barrier maturation are not fully elucidated.
246 as a barrier for organic chemicals using the epithelial barrier model built on the rainbow trout (Onc
247 rfilamentous C. albicans strain breaches the epithelial barrier more frequently and causes mortality
248 physiology reveal a complex interplay of the epithelial barrier, mucosal and systemic immune response
249 between the host and the environment are the epithelial barriers of the skin, gastrointestinal system
251 existing disease and its underlying abnormal epithelial barrier or, alternatively, is linked to corti
253 eplicates in the intestinal mucosa increases epithelial barrier permeability and reveals type I IFNs
254 mmation was associated with impaired colonic epithelial barrier permeability, increased colonic IL-1b
258 We propose that abnormalities in the airway epithelial barrier play a crucial role in the sensitizat
260 eceptor (heat shock protein 60) disrupts the epithelial barrier, promoting bacterial translocation.
262 Maintenance of epithelial cell polarity and epithelial barrier relies on the spatial organization of
263 The functional integrity of the intestinal epithelial barrier relies on tight coordination of cell
264 Expression of several genes associated with epithelial barrier repair (matrix metalloproteinase 7, m
266 ndings indicate that AS II can contribute to epithelial barrier repair following intestinal injury, a
268 y bowel disease, are associated with a leaky epithelial barrier, resulting in excessive exposure to m
269 sure in mice caused damage to the intestinal epithelial barrier, resulting in increased permeability
270 ion, TMOP treatments repaired the intestinal epithelial barrier, reversed the gut microbiota dysbiosi
273 ed population of immune cells that reside at epithelial barrier surfaces such as the skin, lung, and
275 The complex immunoregulatory network of the epithelial barrier surveillance also involves NK gene co
276 f AD has its roots in the dysfunction of the epithelial barrier that allows the penetration of allerg
277 ed by the choroid plexus (ChP), a protective epithelial barrier that also prevents free entry of toxi
278 Mucosal damage results in a compromised epithelial barrier that can lead to excessive immune res
279 indicate the efficacy of a platelet-induced epithelial barrier that functions to prevent bacterial a
280 ssues, including the structure of mucus, the epithelial barrier, the mucosal-associated lymphatic tis
281 these findings, we examined if SCFAs promote epithelial barrier through IL-10RA-dependent mechanisms.
282 anslocation in in vitro simulated intestinal epithelial barrier thus prospecting the occurrence of ad
283 memory T (TRM) cells persist indefinitely in epithelial barrier tissues and protect the host against
284 roles in the development and homeostasis of epithelial barrier tissues; how MASPs are activated in m
286 It has been previously reported that the epithelial barrier to bacterial proinflammatory products
287 st that AMT-101 can efficiently overcome the epithelial barrier to focus biologically active IL-10 to
288 demonstrate that K. pneumoniae disrupts the epithelial barrier to initiate bacterial translocation a
290 are the first IFNs produced that act at the epithelial barrier to suppress initial viral spread with
294 [ABCC1]) is abundantly expressed at the lung epithelial barrier, where it may influence the pulmonary
295 rgic diseases have in common a dysfunctional epithelial barrier, which allows the penetration of alle
296 with significant damage to the oral mucosal epithelial barrier, which might allow profilin penetrati
297 ed for its translocation over the intestinal epithelial barrier, which would bring them in contact wi
298 he secretion of immunoglobulins (Igs) across epithelial barriers, which is achieved via the polymeric
299 ront-line defense that controls infection at epithelial barriers while minimizing damaging inflammato