ライフサイエンスコーパス: epithelial cancer

1 nessed to mediate regression of a metastatic epithelial cancer.

2 Engineered T cells can induce regression of epithelial cancer.

3 ram, suggesting new avenues for treatment of epithelial cancer.

4 n factor for poor prognosis in human ovarian epithelial cancer.

5 he development of many types of lymphoid and epithelial cancers.

6 Mutant KRAS is a common driver in epithelial cancers.

7 g of the extracellular matrix occurs in many epithelial cancers.

8 peripheral blood of patients with cancer for epithelial cancers.

9 mount a mutation-specific T cell response to epithelial cancers.

10 the invasive and metastatic behavior of many epithelial cancers.

11 esting that ZMIZ1 may play a broader role in epithelial cancers.

12 mal region is a common genetic event in many epithelial cancers.

13 recognized as one of the major hallmarks of epithelial cancers.

14 alin family, is up-regulated in a variety of epithelial cancers.

15 a non-receptor tyrosine kinase expressed in epithelial cancers.

16 by inducing invasion and metastasis of human epithelial cancers.

17 quently up-regulated in myeloid leukemia and epithelial cancers.

18 n important mechanism in the pathogenesis of epithelial cancers.

19 ortant implications for our understanding of epithelial cancers.

20 ronic active EBV infection, and lymphoid and epithelial cancers.

21 t for both prevention and therapy of several epithelial cancers.

22 as being important for some mouse and human epithelial cancers.

23 ay deregulation is also enriched in squamous epithelial cancers.

24 ithelial cells and is frequently silenced in epithelial cancers.

25 carcinoma antibody capable of targeting most epithelial cancers.

26 the biology of primary human SCCa and other epithelial cancers.

27 itor-like cells and is overexpressed in many epithelial cancers.

28 are greatly overexpressed in mouse and human epithelial cancers.

29 ncers comprise the most common type of human epithelial cancers.

30 erentiation and contribute to EBV-associated epithelial cancers.

31 known as matriptase, is often upregulated in epithelial cancers.

32 e the etiologic agents of cervical and other epithelial cancers.

33 ace ligand implicated in the pathogenesis of epithelial cancers.

34 ed carbohydrate-dependent lung metastasis of epithelial cancers.

35 netic pathways in genetically complex common epithelial cancers.

36 is now being applied to patients with common epithelial cancers.

37 letal dynamics, is commonly deleted in human epithelial cancers.

38 ating serine/threonine kinases implicated in epithelial cancers.

39 ure of the underlying genetic basis of human epithelial cancers.

40 ular, as well as hepatic metastases of other epithelial cancers.

41 tic effects against ovarian and other lethal epithelial cancers.

42 ematologic cancers with potential utility in epithelial cancers.

43 ontributing to the pathogenesis of malignant epithelial cancers.

44 i are candidates for susceptibility to other epithelial cancers.

45 static human papillomavirus (HPV)-associated epithelial cancers.

46 clinical success in the treatment of diverse epithelial cancers.

47 hrough unknown mechanisms in a wide range of epithelial cancers.

48 rategies for the treatment of skin and other epithelial cancers.

49 tial alterations in the development of human epithelial cancers.

50 ancer susceptibility factor for a variety of epithelial cancers.

51 stinal hamartomas and increased incidence of epithelial cancers.

52 n, is hypo-glycosylated and overexpressed on epithelial cancers.

53 nase for possible broad application to treat epithelial cancers.

54 nts a potential therapeutic target for human epithelial cancers.

55 uppressor and a tumor promoter in many solid epithelial cancers.

56 the pathogenesis of several murine and human epithelial cancers.

57 ssary for the development and progression of epithelial cancers.

58 ) is a critical mediator of several types of epithelial cancers.

59 tions for development of cellular therapy in epithelial cancers.

60 e causative agent of cervical and some other epithelial cancers.

61 deformities of hands and feet and aggressive epithelial cancers.

62 ption of the tumour suppressor E-cadherin in epithelial cancers.

63 pical-basal polarity, a hallmark of advanced epithelial cancers.

64 ant expression of O-glycans is a hallmark of epithelial cancers.

65 pithelial cells but is overexpressed in many epithelial cancers.

66 at predisposes to breast, thyroid, and other epithelial cancers.

67 adhesion molecules, as a potential target in epithelial cancers.

68 is the causative agent of cervical and other epithelial cancers.

69 with reduced patient survival across various epithelial cancers.

70 ce variants have been previously reported in epithelial cancers.

71 ark of diseases ranging from inflammation to epithelial cancers.

72 tly amplified and rearranged in 15% of human epithelial cancers.

73 f Rb in the mouse has so far failed to yield epithelial cancers.

74 sponse against mutations expressed by common epithelial cancers.

75 apy and extending it toward the treatment of epithelial cancers.

76 the reach of ACT to the treatment of common epithelial cancers.

77 powerful prognostic measure across different epithelial cancers.

78 4 dependence was not found to be critical in epithelial cancers.

79 rovide a novel target to limit the spread of epithelial cancers.

80 sposition events have been shown to occur in epithelial cancers.

81 c driver of lymphocyte mimicry in metastatic epithelial cancers.

82 as practical implications for the therapy of epithelial cancer and gene/drug delivery to normal epith

83 II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines.

84 matriptase is a consistent feature of human epithelial cancers and correlates with poor disease outc

85 tein alpha (FAPalpha) is highly expressed in epithelial cancers and has been implicated in extracellu

86 Slx4-deficient mice develop epithelial cancers and have a contracted hematopoietic s

87 tly expressed in EBV-associated lymphoid and epithelial cancers and have complex effects on cell sign

88 s ineffective as a single agent for treating epithelial cancers and induces hypertriglyceridemia.

89 e kinase that is overexpressed in many human epithelial cancers and is a potential target for antican

90 ce to an SCN state that is widespread across epithelial cancers and is associated with poor prognosis

91 d in stromal fibroblasts in more than 90% of epithelial cancers and is associated with tumor progress

92 e 3 beta (GSK3beta) is highly inactivated in epithelial cancers and is known to inhibit tumor migrati

93 expression of miR-125b is known to occur in epithelial cancers and many target mRNAs for this miR ha

94 e most prevalent glycolipid in a majority of epithelial cancers and one that acts as an immune checkp

95 , EphB4 is expressed in the vast majority of epithelial cancers and provides a survival advantage to

96 rkedly induced in a variety of primary human epithelial cancers and renders cancer cells resistant to

97 ranscription 3 (STAT3) is altered in several epithelial cancers and represents a potential therapeuti

98 is the most commonly dysregulated pathway in epithelial cancers and represents an important target fo

99 ment, organism survival, and in cancer, both epithelial cancers and sarcomas.

100 man cancer cells originating from both solid epithelial cancers and some hematological malignancies i

101 HOTAIR is a lncRNA overexpressed in several epithelial cancers and strongly correlated with invasion

102 autofluorescent phenotype in CSCs of diverse epithelial cancers and used this marker to isolate and c

103 ated on 20q12, which is amplified in several epithelial cancers and well studied in breast cancer.

104 unction at the centrosome is associated with epithelial cancers and with invasive behavior in tumor c

105 Thus, Ras induces ARC in epithelial cancers, and ARC plays a role in the oncogeni

106 pressed in a significant proportion of human epithelial cancers, and experimental overexpression of c

107 pression in DLBCL is similar to that seen in epithelial cancers, and low-grade non-Hodgkin B-cell lym

108 rt arm of chromosome 8 is frequently lost in epithelial cancers, and NRG1 is the most centromeric gen

109 human herpesvirus that can cause lymphomas, epithelial cancers, and other diseases, most of which re

110 metes, myoblasts, macrophages, trophoblasts, epithelial, cancer, and other cells in normal developmen

111 Cell surfaces of epithelial cancer are covered by complex carbohydrates,

112 Chromosome translocations in the common epithelial cancers are abundant, yet little is known abo

113 Epithelial cancers are associated not only with changes

114 Many human epithelial cancers are characterized by abnormal activat

115 Some epithelial cancers are known to occur in transitional zo

116 ch all primary tumors arise de novo, ovarian epithelial cancers are primarily imported from either en

117 Epithelial cancers are the most common malignancies and

118 s of highly lethal and poorly differentiated epithelial cancers arising mainly in human midline organ

119 t p130 or p107 cooperate with Rb to suppress epithelial cancers associated with p16 loss is currently

120 (CT) antigen, CT45, is expressed in various epithelial cancers at a frequency of <5% to approximatel

121 o new functions of CD98hc that contribute to epithelial cancer beyond an intrinsic effect of CD98hc o

122 cient to mediate p53 tumor suppression in an epithelial cancer, but not in this model of soft tissue

123 s of polarity correlates with progression of epithelial cancers, but how plasma membrane misorganizat

124 ssed and/or constitutively active in several epithelial cancers, but its role in pancreatic cancer is

125 BACKGROUND & AIMS: Epithelial cancers can be initiated by activating mutati

126 RCP overexpression, which is common in human epithelial cancers, causes oncogenic transformation of h

127 recently reported to have a pivotal role in epithelial cancer cell growth in culture and in xenograf

128 f telomerase has been identified in alveolar epithelial cancer cell line (A549).

129 ntrol normal lung cells (CCD-32Lu); alveolar epithelial cancer cell line (A549); large cell carcinoma

130 serine-2):ERG fusion-positive human prostate epithelial cancer cell line (VCaP) cells revealed distin

131 fluence adenovirus type 5 (Ad5) spread in an epithelial cancer cell line.

132 at is active against a panel of hard-to-kill epithelial cancer cell lines (including triple-negative

133 Consistent with these findings, epithelial cancer cell lines expressing higher E-cadheri

134 the high levels of BAG3 protein seen in some epithelial cancer cell lines may be relevant to mechanis

135 G3 protein is highly expressed in many human epithelial cancer cell lines, especially adenocarcinomas

136 increases its expression in multiple ovarian epithelial cancer cell lines.

137 ent also reduces the percentage of the total epithelial cancer cell population staining CD44-positive

138 is essential for communication between many epithelial cancer cell types and the tumor microenvironm

139 Here, we show that epithelial cancer cells (A431, DLD-1) adopt mesenchymal

140 e method is verified by using primary breast epithelial cancer cells (MCF-7) at passage 4.

141 our platform, we demonstrate a coculture of epithelial cancer cells and endothelial cells.

142 ivered with streptolysin O into living human epithelial cancer cells and primary chicken fibroblasts,

143 mulation, is theorized to take place between epithelial cancer cells and surrounding non-neoplastic s

144 strated that stromal fibroblasts adjacent to epithelial cancer cells are senescent in human ovarian c

145 18 expression can influence the phenotype of epithelial cancer cells at a transcriptional level and s

146 etastasis, imparted by EMT cells on adjacent epithelial cancer cells can be disrupted by either inhib

147 Ad-E1A12 infection of epithelial cancer cells displayed dramatic detachment an

148 Nevertheless, FN matrix regulation in epithelial cancer cells during hypoxia remains less well

149 Aggressive epithelial cancer cells frequently adopt mesenchymal cha

150 The metastatic spread of epithelial cancer cells from the primary tumor to distan

151 to an unexpected transcriptome plasticity of epithelial cancer cells in bone marrow and question comm

152 Interestingly, long-term-cultured human epithelial cancer cells in clonal cultures also form hol

153 o-mesenchymal transition and stemness of the epithelial cancer cells in vivo.

154 Enforced expression of HOTAIR in epithelial cancer cells induced genome-wide re-targeting

155 lasts cultured with cytotoxic drugs and dead epithelial cancer cells isolated from peripheral blood o

156 MUC1 is typically aberrantly glycosylated by epithelial cancer cells manifested by truncated O-linked

157 Similarly to healthy cells, prostate epithelial cancer cells produce extracellular vesicles (

158 f either FGFR2-IIIb or FGFR2-IIIc in thyroid epithelial cancer cells reduced expression of fibronecti

159 Thus, epithelial cancer cells rely on the canonical PI3K-AKT s

160 n tumor-infiltrating hematopoietic cells and epithelial cancer cells results in their fusion.

161 Here, we tracked epithelial cancer cells that underwent inducible or spon

162 natural compound that activates apoptosis of epithelial cancer cells through activation of tumor necr

163 hibitors, can upregulate immune signaling in epithelial cancer cells through demethylation of endogen

164 This process enables epithelial cancer cells to acquire mobility and traits a

165 However, the molecular signal used by epithelial cancer cells to reprogram normal stroma to a

166 Epithelial cancer cells upon Ad-E1A12-induced detachment

167 ived cells, and hFX-enhanced transduction in epithelial cancer cells were dependent on HSPGs.

168 ed intratumor heterogeneous expression among epithelial cancer cells were selected for cell sorting a

169 able to trigger opening of junctions between epithelial cancer cells which, in turn, greatly improved

170 cation of OT-II white blood cells and SW-480 epithelial cancer cells with more than 95% accuracy in a

171 sed collective migration and invasiveness of epithelial cancer cells without modulating EMT markers.

172 d AKT1 phosphorylation was PI3K-dependent in epithelial cancer cells, and mTOR-dependent in mesenchym

173 im may function as a prosurvival molecule in epithelial cancer cells, and phosphorylation and associa

174 ed DNA damage elicits genomic instability in epithelial cancer cells, but apoptosis is blocked throug

175 he nucleus and the leading edge of migrating epithelial cancer cells, correlates with faster migratio

176 In murine mammary epithelial cancer cells, galectin-3 binding to beta1,6-a

177 lastic transformation and invasive growth of epithelial cancer cells, our study on the role of EMMPRI

178 The DeltaNp63-HK2 axis is also present in epithelial cancer cells, suggesting that DeltaNp63 could

179 , we discuss the functional role of Cav-1 in epithelial cancer cells.

180 anglioside in cell-cell junctions of mammary epithelial cancer cells.

181 on of migratory and invasive capabilities by epithelial cancer cells.

182 which interacts with VEGF-C, in neighboring epithelial cancer cells.

183 CTCs have focused mainly on the detection of epithelial cancer cells.

184 (v13) form homodimers at the cell surface of epithelial cancer cells.

185 njured tissues, and initiating metastasis of epithelial cancer cells.

186 neities and tumorigenic hierarchies in human epithelial cancer cells.

187 intracellular signaling and DSG2 shedding in epithelial cancer cells.

188 In epithelial cancers, cells must invade through basement m

189 the first to report the presence of a hemato-epithelial cancer compartment, which contributes to stem

190 The karyotypic chaos exhibited by human epithelial cancers complicates efforts to identify mutat

191 ber, p73, is frequently deregulated in human epithelial cancers, correlating with tumor invasiveness,

192 Many epithelial cancers develop proximally to microbial commu

193 iven the importance of replication stress in epithelial cancer development and of an HR defect in bre

194 ates key events in keratinocyte function and epithelial cancer development.

195 arimetric endoscope include wide field early epithelial cancer diagnosis, surgical margin detection a

196 In non-epithelial cancers, different mechanisms must underlie m

197 -based targeting of FGFR3 in hematologic and epithelial cancers driven by WT or mutant FGFR3.

198 to platin drugs are greatly needed in human epithelial cancers (e.g., ovarian, head/neck, and lung)

199 In prostate and other epithelial cancers, E-cadherin (CDH1) is downregulated i

200 tein, which is overexpressed in a variety of epithelial cancers (eg.

201 an event associated with the progression of epithelial cancers, entosis--along with apoptosis--may c

202 profile 500 cell lines derived from diverse epithelial cancers for sensitivity to 14 kinase inhibito

203 both a colon cancer and a second independent epithelial cancer had developed.

204 However, its role in epithelial cancers has not been extensively investigated

205 cal cancer, as well as a proportion of other epithelial cancers, has led to development of three FDA-

206 of the fallopian tube, suggesting that these epithelial cancers have a mesenchymal origin.

207 tumor activity of rhApo2L/TRAIL in models of epithelial cancers; however, efficacy in non-Hodgkin lym

208 hat inflammation leads to the development of epithelial cancers; however, studies on inflammation-tar

209 POZ-domain genes in the development of human epithelial cancers, i.e., carcinomas.

210 d urothelial carcinoma is the most prevalent epithelial cancer in long-term survivors of hereditary r

211 ggested to contribute to the reduced risk of epithelial cancers in adults with DS, leading to the pos

212 aneuploid, heterogeneous, and transplantable epithelial cancers in mice.

213 have shown robust antitumor activity against epithelial cancers in vitro but not in the clinic becaus

214 ssion of C/EBPalpha occurs in numerous human epithelial cancers including lung, liver, endometrial, s

215 n, as well as copy-number losses in multiple epithelial cancers, including breast cancer, DEAR1 has c

216 in the treatment of many of the most common epithelial cancers, including breast cancer.

217 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostat

218 pathway, Hh ligands expressed by a subset of epithelial cancers, including colon, pancreatic, and ova

219 malities of prenatal development and several epithelial cancers, including hepatocellular carcinoma (

220 show upregulated ST6Gal-I protein in several epithelial cancers, including many colon carcinomas.

221 highly prevalent herpesvirus associated with epithelial cancers, including nasopharyngeal carcinoma (

222 rare gene fusions may occur in other common epithelial cancers, including prostate cancer.

223 PKCepsilon is up-regulated in most epithelial cancers, including prostate, breast, and lung

224 ccessfully for the prevention of a number of epithelial cancers, including skin squamous cell carcino

225 implicated in the development of many human epithelial cancers, including those of the stomach, lung

226 V infections are an important driver of many epithelial cancers, including those within the anogenita

227 s and may shed light on the role of SIRT1 in epithelial cancer induced by DNA damage.

228 Here we show that growth of epithelial cancers induces compressive remodeling of the

229 signature from multiple transgenic models of epithelial cancers intrinsic to the functions of the Sim

230 ts frequent overexpression in major forms of epithelial cancer is associated with aneuploidy and carc

231 However, its importance in spontaneous epithelial cancer is still poorly defined.

232 d its overexpression in myeloid leukemia and epithelial cancers is associated with poor patient survi

233 is estimated that the etiology of 20-30% of epithelial cancers is directly associated with inflammat

234 al functions, yet the role of pS-STAT3 among epithelial cancers is ill-defined.

235 ng the role of TGFbeta in the progression of epithelial cancers is the elucidation of the mechanisms

236 ne neoplasias; however, its role in sporadic epithelial cancers is unknown.

237 overexpressed and aberrantly glycosylated in epithelial cancer, is a natural ligand for galectin-3.

238 nhance T(R)-cell potency and protect against epithelial cancers later in life, potentially explaining

239 In the vast majority of cases, in situ epithelial cancer lesions do not progress into malignanc

240 ed for prediction and diagnosis of precursor epithelial cancer lesions.

241 pled receptor (GPCR), is induced in multiple epithelial cancer lineages.

242 r Bacillus Calmette-Guerin levels in mammary epithelial cancer MCF-7 cells.

243 et al. show that a fraction of patients with epithelial cancers mount antigen-specific T cell respons

244 s; none were captured from patients with non-epithelial cancer (n = 20) or healthy subjects (n = 25).

245 neral characteristic of "cells-of-origin" in epithelial cancers, namely their propensity for switch t

246 onal-like cells, which are distinct from the epithelial cancers observed in adults, and etiologically

247 re histologically or cytologically confirmed epithelial cancer of the ovary, fallopian tube, or perit

248 cal subtype, or any FIGO (1988) stage IIB-IV epithelial cancer of the ovary, fallopian tube, or prima

249 st to accelerated cancer onset and increased epithelial cancers of late-generation mTerc-/- p53 mutan

250 eck squamous cell carcinoma (HNSCC) includes epithelial cancers of the oral and nasal cavity, larynx,

251 on and for the surgical-margin assessment of epithelial cancers of the upper intestinal tract.

252 r transformation and metastatic potential of epithelial cancers, our findings support a tumor suppres

253 PKCvarepsilon is frequently overexpressed in epithelial cancers, particularly in lung cancer.

254 rowth factor receptor (EGFR) is prevalent in epithelial cancers, particularly in non-small cell lung

255 s can be detected in the peripheral blood of epithelial cancer patients and can potentially be used f

256 blood of patients with the common metastatic epithelial cancer patients is unknown.

257 tions can induce durable tumor regression in epithelial cancer patients.

258 High-grade serous carcinoma (HGSC), an epithelial cancer phenotype, is the most common malignan

259 Progression of epithelial cancers predominantly proceeds by collective

260 n of integrin alphavbeta3, a known driver of epithelial cancer progression and drug resistance.

261 w method for studying CTC in mouse models of epithelial cancer, providing the foundation for studies

262 clinical efficacy against many common solid epithelial cancers remains low.

263 factor receptor (EGFR) is a hallmark of many epithelial cancers, rendering this receptor an attractiv

264 that are strikingly similar to the malignant epithelial cancer, squamous cell carcinoma.

265 Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been possib

266 is unknown whether epithelial stem cells or epithelial cancer stem cells are able to undergo EMT, an

267 Hence, targeting epithelial cancer stem cells with rapid tumorigenesis si

268 ssion-emerging as a widespread phenomenon in epithelial cancers such as bladder, pancreas, colon, and

269 gements may play an important role in common epithelial cancers such as breast cancer.

270 we show that LARP1 expression is elevated in epithelial cancers such as cervical and non-small cell l

271 arget because of its expression on different epithelial cancers, such as ovarian, non-small cell lung

272 In epithelial cancers, such as those of the breast, the epi

273 rder characterized by high lifetime risks of epithelial cancers, such that approximately 50% of affec

274 ot only in prostate cancer but also in other epithelial cancers that are associated with the 8q24 loc

275 ese features are particular hallmarks of the epithelial cancers that are some of the malignancies mos

276 amplification may thus identify a subset of epithelial cancers that are uniquely sensitive to disrup

277 This is in contrast to other epithelial cancers that have up-regulated branching enzy

278 This applies especially to epithelial cancer, the most common form of human solid t

279 In Epstein-Barr virus-infected epithelial cancers, the alternatively spliced BamHI A ri

280 Evi1 has recently been implicated in certain epithelial cancers, the effects of Evi1 on transformatio

281 helf' receptors targeting shared antigens on epithelial cancers, the leading cause of cancer-related

282 sufficiently on the cell surface in several epithelial cancers, thereby making it suitable for preta

283 n is a key factor driving metastasis in most epithelial cancers, this high-affinity TFD100 should be

284 t signalling in T cells leads to spontaneous epithelial cancers throughout the gastrointestinal tract

285 lular program involved in the progression of epithelial cancers to a metastatic stage.

286 tened expression of Trop2 is selected for in epithelial cancers to enhance the stem-like properties o

287 ble clinical benefit in patients with common epithelial cancers.TRIAL REGISTRATIONPhase I/II protocol

288 2, a suppressor of breast, ovarian and other epithelial cancers, triggers instability in chromosome s

289 d cancer invasion and metastasis of multiple epithelial cancer types.

290 angiocarcinoma represents a diverse group of epithelial cancers united by late diagnosis and poor out

291 activity as a useful biomarker to visualize epithelial cancers using a noninvasive antibody-based me

292 in approximately half of several other major epithelial cancers, we provide evidence suggesting that

293 xpressing cells promoted significant mammary epithelial cancers when injected into nude mice, as comp

294 enter trial involving patients with advanced epithelial cancers who received sacituzumab govitecan-hz

295 in early detection of GC and possibly other epithelial cancers with premalignant immune involvement.

296 FR is expressed on a variety of epithelial cancers, with advanced cancers often expressi

297 ion antigen that is highly expressed in many epithelial cancers, with limited expression in normal hu

298 eterogeneity within seven types of untreated epithelial cancers, with particular regard to its clinic

299 In a human epithelial cancer xenograft model, Ad14P1 showed more ef

300 apten-peptide were assessed in several human epithelial cancer xenografts.