ライフサイエンスコーパス: epithelial polarity

1 embrane of epithelial cells, is required for epithelial polarity.

2 o counterparts, D407 cells maintain reversed epithelial polarity.

3 i or for the establishment or maintenance of epithelial polarity.

4 ermline and strongly impairs BAZ function in epithelial polarity.

5 lization, and loss of both pathways disrupts epithelial polarity.

6 ps mutants internalize normally and maintain epithelial polarity.

7 ns (tight junctions) and appears to regulate epithelial polarity.

8 ction formation, intercellular adhesion, and epithelial polarity.

9 rumbs, a conserved regulator of apical-basal epithelial polarity.

10 t appear to be independent of the defects in epithelial polarity.

11 ryonic elongation and establishment of early epithelial polarity.

12 nt, and the establishment and maintenance of epithelial polarity.

13 product of stardust is required to maintain epithelial polarity.

14 ee lines, formed 3D spheroids that displayed epithelial polarity.

15 erent and tight junction proteins, affecting epithelial polarity.

16 (aPKCs) are implicated as key regulators of epithelial polarity.

17 ommon Rab compartment architecture underlies epithelial polarity.

18 function that is separable from its role in epithelial polarity.

19 with which to understand the coordination of epithelial polarity.

20 llular junctional complexes defining mammary epithelial polarity.

21 er-dependent in establishing and maintaining epithelial polarity.

22 ere establishes AP-1 as a major regulator of epithelial polarity.

23 ired for the mesoderm primordium to lose its epithelial polarity.

24 at Rap1 and Rac1 signal independently during epithelial polarity.

25 f adherens junctions components, and loss of epithelial polarity.

26 lls is necessary for proper establishment of epithelial polarity.

27 tive pathway modulating the establishment of epithelial polarity.

28 of the Crumbs-PALS1-PATJ complex function in epithelial polarity.

29 The proper establishment of epithelial polarity allows cells to sense and respond to

30 Accordingly, we hypothesized that airway epithelial polarity allows different responses to basola

31 croRNA-dependent regulation to disruption of epithelial polarity and aberrant mammary stem cell divis

32 novel insight into the intimate link between epithelial polarity and acquisition of motile polarity t

33 the apical domain, thus establishing apical epithelial polarity and adherens junctions.

34 overlying periderm (resulting in compromised epithelial polarity and adhesiveness) and in kidney and

35 d prkczeta are essential to establish tubule epithelial polarity and also serve to maintain proper ep

36 n complexes have pivotal roles in control of epithelial polarity and apical membrane formation.

37 hectoderm, concomitant with establishment of epithelial polarity and appearance of a blastocoel cavit

38 Neural rosettes contain NSCs with strong epithelial polarity and are expected to perform apical-b

39 nd tight junction (TJ) are key regulators of epithelial polarity and barrier function.

40 t protein receptor Syntaxin 3 (Stx3) disturb epithelial polarity and cause microvillus inclusion dise

41 sion causes cell motility and down-regulates epithelial polarity and cell adhesion proteins.

42 evelopment and cancer and entail the loss of epithelial polarity and cell adhesion.

43 rafficking or Vangl-Celsr complexes disrupts epithelial polarity and cell division orientation.

44 organs pattern, but the relationship between epithelial polarity and cell fate is poorly understood.

45 res without restricting the establishment of epithelial polarity and changes in gene expression.

46 reviously implicated in the establishment of epithelial polarity and control of cell growth, is requi

47 eath from cancer in humans, involves loss of epithelial polarity and dedifferentiation.

48 The genetic control of mammalian epithelial polarity and dynamics can be studied in vivo

49 Thus, the BLJ appears to regulate epithelial polarity and dynamics not only as a localized

50 perfamily, is essential for the formation of epithelial polarity and for neuronal development during

51 ays a key role in the spatial orientation of epithelial polarity and formation of lumens in glandular

52 Epithelial polarity and function of these easily reprodu

53 sely, villin is also linked with the loss of epithelial polarity and gain of the mesenchymal phenotyp

54 a adherens (adherens junctions) to establish epithelial polarity and helps to orient the mitotic spin

55 ablish a direct link between modification of epithelial polarity and initiation of epithelial folding

56 pical membrane morphogenesis, rather than in epithelial polarity and junction assembly as has been pr

57 ily conserved Crumbs protein is required for epithelial polarity and morphogenesis.

58 Whereas Crumbs is implicated in apical-basal epithelial polarity and photoreceptor morphogenesis, the

59 tions to open questions in current models of epithelial polarity and polarized trafficking.

60 hus, LKB1 signals through AMPK to coordinate epithelial polarity and proliferation with cellular ener

61 ct RPE is not sufficient to maintain retinal epithelial polarity and retinal cellular pattern formati

62 la Discs Lost, a protein that is crucial for epithelial polarity and that exists in a complex with th

63 esting that the cfy gene is not critical for epithelial polarity and that polarity defects are unlike

64 le in determining the spatial orientation of epithelial polarity and the formation of lumens in gland

65 separate complexes that cooperate to control epithelial polarity and the formation of zonula adherens

66 KCiota is essential for the establishment of epithelial polarity and the normal assembly of tight jun

67 d by Hippo pathway signalling in response to epithelial polarity and tissue mechanics during developm

68 ent transcription are to mediate the loss of epithelial polarity and to promote fibroblast activities

69 erved but poorly defined roles in regulating epithelial polarity and, in photoreceptor cells, morphog

70 l role in E-cadherin-mediated development of epithelial polarity, and suppression of invasiveness and

71 , the Crumbs (Crb) proteins are important in epithelial polarity, apical membrane formation, and tigh

72 nisms that regulate the development of renal epithelial polarity are incompletely understood.

73 equired for establishing the early embryonic epithelial polarity are used later for the morphogenesis

74 ayered acini devoid of lumen, with disrupted epithelial polarity, as shown by an altered localization

75 n inability to establish normal apical/basal epithelial polarity, as well as proper cell-cell contact

76 as been intensively studied for its roles in epithelial polarity, asymmetric neural divisions, and re

77 tases, plays an important role in regulating epithelial polarity by controlling the phosphorylation o

78 herins play an essential role in maintaining epithelial polarity by forming Ca2+-dependent adherens j

79 We have investigated the role of PAR-1 in epithelial polarity by generating null mutant clones in

80 We propose that the Scrib module regulates epithelial polarity by influencing endocytic itineraries

81 Pathogens can alter epithelial polarity by recruiting polarity proteins to t

82 Our data reveal a role for spatiotemporal epithelial polarity changes in the activation of innate

83 ption factor-1 (Zeb1), a master regulator of epithelial polarity, controls neuronal differentiation b

84 to crumbs mutants, magu-2 deletion showed no epithelial polarity defects.

85 fibers, tight junctions, or desmosomes, and epithelial polarity developed normally, suggesting that

86 Thus, although epithelial polarity develops in the absence of AJs, AJs

87 NAs from the patient cohort were involved in epithelial polarity disruption.

88 sides its well documented role in regulating epithelial polarity, Dlgh1 also regulates smooth muscle

89 However, proper retinal epithelial polarity does not require retinal expression

90 ve splicing by the Obelus helicase modulates epithelial polarity during development.

91 Thus, we examined epithelial polarity establishment during early Drosophil

92 Thus, Baz acts upstream of AJs during epithelial polarity establishment.

93 Loss of the epithelial polarity gene scribble in clones of Drosophil

94 ects D. melanogaster cells with mutations in epithelial polarity genes, and wild-type cells exposed t

95 Although roles in epithelial polarity, granule assembly, and mucosal prote

96 with chronic inflammation and disruption of epithelial polarity identified as key drivers of tumor p

97 some and dense EVs preparations suggest that epithelial polarity impacts directional release.

98 Loss of epithelial polarity impacts organ development and functi

99 ndicate that HPPL develop cholangiocyte-type epithelial polarity in 3D culture.

100 pathway is required for the establishment of epithelial polarity in a variety of vertebrate and inver

101 epithelial cell polarity, but the origin of epithelial polarity in Drosophila remains unclear.

102 ), has recently been linked to regulation of epithelial polarity in Drosophila.

103 These defects lead to loss of epithelial polarity in mutant tissues, which overprolife

104 LKB1/STRAD can also trigger establishment of epithelial polarity in the absence of cell-cell or cell-

105 ing pathway plays a key role in establishing epithelial polarity in the compound eye of Drosophila.

106 teracting proteins critical for establishing epithelial polarity, in an undifferentiated neurite corr

107 or zebrafish crb2b, a conserved regulator of epithelial polarity, in podocyte morphogenesis.

108 iseases and function in complexes regulating epithelial polarity, ion channels, cochlear hair cell de

109 Epithelial polarity is established and maintained by com

110 Epithelial polarity is established locally, within indiv

111 d that Bazooka (Baz) acts upstream of AJs as epithelial polarity is first established in Drosophila.

112 rovide a dynamic model for understanding how epithelial polarity is maintained in Drosophila follicle

113 epair programs, and provide insight into why epithelial polarity is tumor-suppressive.

114 budding yeast, but whether they function in epithelial polarity is unknown.

115 stabilizes cell-cell junctions and maintains epithelial polarity; its activation by Metformin protect

116 We found that epithelial polarity loss also occurs in a 3D coculture s

117 , this analysis reveals a novel role for the epithelial polarity machinery, Cdc42-Par6-aPKC, in local

118 osis and proliferation, and in expression of epithelial polarity markers.

119 ter the redistribution of apical-basolateral epithelial polarity markers.

120 d on the dysregulation of tight junction and epithelial polarity master genes via upregulation of ZEB

121 In prevailing epithelial polarity models, membrane- and junction-based

122 In prevailing epithelial polarity models, membrane-based polarity cues

123 nced for gap junction Cx43 (Cx43-KO-S1) lose epithelial polarity, multilayer and mimic premalignant i

124 PDLIM2 supports the epithelial polarity of nontransformed breast cells, sugg

125 es, it was found that, during acquisition of epithelial polarity, OFD1 became localized to the apical

126 that in intestine, CASK is not required for epithelial polarity or differentiation but is necessary

127 dherin in MSV-MDCK cells did not reestablish epithelial polarity or inhibit the invasiveness and moti

128 ization of DLG1 are not essential for either epithelial polarity or intestinal homeostasis in vivo.

129 ng the basal polarity cue for the low-energy epithelial polarity pathway.

130 The Epithelial Polarity Program (EPP) adapts and integrates

131 trinsic tumor-suppressive mechanism, whereby epithelial polarity proteins dictate the cytoarchitectur

132 e cell cycle, but was blocked by loss of the epithelial polarity proteins Scribble or Pard3, or by in

133 However, less is known about what becomes of epithelial polarity proteins when various cell types bec

134 ctin cytoskeletal architecture, altered Arf6 epithelial polarity, reduced adherens junctions, loss of

135 ins that have been implicated in maintaining epithelial polarity, regulating paracellular transport,

136 e function may contribute not only to normal epithelial polarity regulation but also may promote path

137 rotein kinase that plays a conserved role in epithelial polarity regulation in mammals and Drosophila

138 er, information on Msx's roles in regulating epithelial polarity remains limited.

139 Establishment of epithelial polarity requires the reorganization of the m

140 Cortical force generators connect epithelial polarity sites with astral microtubules, allo

141 The involvement of the Slmb E3 ligase in epithelial polarity, specifically limiting Par complex a

142 lkb1 mutant clones also disrupt apical-basal epithelial polarity, suggesting a general role in cell p

143 id not affect the formation of junctions and epithelial polarity, suggesting that the intracellular N

144 rens junctions is one of the many aspects of epithelial polarity that is established during cellulari

145 al stem cell marker implicated previously in epithelial polarity that is upregulated in SCC cells.

146 sis and identify key miRNA players in breast epithelial polarity, the miRNA profile specific to Cx43

147 The AMP-stimulated protein kinase regulates epithelial polarity under conditions of energy depletion

148 The maintenance of epithelial polarity under energetic stress requires the

149 We further show that RPE-mediated retinal epithelial polarity underlies proper patterning of retin

150 We provide data demonstrating that epithelial polarity via cyst lumen formation is governed

151 ectrin-based membrane skeleton in generating epithelial polarity, we characterized the distribution o

152 ks the EPP machineries, resulting in loss of epithelial polarity, which often correlates in extent wi

153 ormation of tight junctions, desmosomes, and epithelial polarity with the use of the calcium switch m

154 s, prevents establishment and maintenance of epithelial polarity, with no junctional formation and ab