ライフサイエンスコーパス: epithelial tumor

1 1(+) EMT cells had the ability to seed a new epithelial tumor.

2 r, probably a leiomyosarcoma, rather than an epithelial tumor.

3 have implications for the treatment of human epithelial tumors.

4 causally linked to differentiation blocks in epithelial tumors.

5 o thirds of which develop ovarian or uterine epithelial tumors.

6 ice that subsequently developed reproductive epithelial tumors.

7 mplicated in the development of lymphoid and epithelial tumors.

8 ctivity in mice is found to result in ureter epithelial tumors.

9 R is a major anticancer drug target in human epithelial tumors.

10 hamartomas and a susceptibility to malignant epithelial tumors.

11 leted in non-Hodgkin's lymphomas and various epithelial tumors.

12 both steroid and growth factor signaling in epithelial tumors.

13 m, and ErbB-2 is frequently overexpressed in epithelial tumors.

14 t within the stroma of the majority of human epithelial tumors.

15 and Ras-transformed fibroblasts and in many epithelial tumors.

16 ase reduced neuroendocrine transition of the epithelial tumors.

17 ed with the development of both lymphoid and epithelial tumors.

18 cal behavior and prognosis for several human epithelial tumors.

19 t contribute to the progression of glandular epithelial tumors.

20 isoforms is frequently deregulated in human epithelial tumors.

21 aberrant promoter methylation in aggressive epithelial tumors.

22 inates gastrointestinal (GI) carcinoids from epithelial tumors.

23 re follicles produced hair co-occurring with epithelial tumors.

24 with characteristics of both mesenchymal and epithelial tumors.

25 in activated dendritic cells, and in several epithelial tumors.

26 tase is a highly consistent feature of human epithelial tumors.

27 genomic instability and tumor development in epithelial tumors.

28 in hematopoietic malignancies, as well as in epithelial tumors.

29 nd cancer progression in a variety of common epithelial tumors.

30 ry cycle and influence the growth of ovarian epithelial tumors.

31 asiveness and poor prognosis of a variety of epithelial tumors.

32 ncluding leukemias, lymphomas, sarcomas, and epithelial tumors.

33 family that is abnormally activated in many epithelial tumors.

34 n contribute to the growth and malignancy of epithelial tumors.

35 expression, predominantly in differentiated epithelial tumors.

36 BRLF1 proteins for treatment of EBV-positive epithelial tumors.

37 KT prosurvival signal independent of PTEN in epithelial tumors.

38 ered that it is deleted in a large number of epithelial tumors.

39 phogenesis, wound healing, and metastasis of epithelial tumors.

40 EGF) receptor is frequently overexpressed in epithelial tumors.

41 delta T cells and is frequently expressed in epithelial tumors.

42 ression was undetectable in more than 60% of epithelial tumors.

43 for gene delivery into epithelial tissues or epithelial tumors.

44 e with a poor prognosis for several types of epithelial tumors.

45 epeatedly reported in colon cancer and other epithelial tumors.

46 sarcomas presaged a widespread discovery in epithelial tumors.

47 t may help to assess and characterize thymic epithelial tumors.

48 e women; age range, 35-71 years) with thymic epithelial tumors.

49 or to generate cell lines from EBV-infected epithelial tumors.

50 ffective therapeutic immunity against lethal epithelial tumors.

51 helial cells targeted by cytomegalovirus and epithelial tumors.

52 ibrosis; and the stromal reaction to certain epithelial tumors.

53 clear whether these cells also contribute to epithelial tumors.

54 and progression of many hormonally regulated epithelial tumors.

55 How epithelial tumors acquire anchorage independence for sur

56 terest in the role of fusion genes in common epithelial tumors after the discovery of recurrent TMPRS

57 he following: (1) CD4+ CD25+ Foxp3+ surround epithelial tumor aggregates; (2) Immature dendritic cell

58 r-associated fibroblasts in more than 90% of epithelial tumors and contributes to progression and wor

59 ese cells, we examined primary human ovarian epithelial tumors and found that MEF is expressed in a s

60 tumor, but also is found expressed in other epithelial tumors and in a subset of normal epithelia.

61 important consequences in the progression of epithelial tumors and in determining the outcome of chem

62 More strikingly, tempol delayed the onset of epithelial tumors and increased the mean epithelial tumo

63 FIP1 is commonly observed during invasion of epithelial tumors and is associated with poor prognosis

64 sociated with a number of human lymphoid and epithelial tumors and lymphoproliferative diseases in im

65 tical for maintaining the integrity of solid epithelial tumors and prevent the infiltration of oncolo

66 e that LIN28A is reactivated in about 10% of epithelial tumors and promotes cell cycle progression by

67 ue to the absence of C/EBPalpha mutations in epithelial tumors and the lethal effect of C/EBPalpha de

68 er propagating stem-like cell populations in epithelial tumors and, especially, glioblastomas.

69 nt tumorigenicity, ability to reestablish an epithelial tumor, and enhanced resistance to drugs and r

70 Twenty-four patients had epithelial tumors, and 20 had sarcomatous or mixed histo

71 few fusion oncogenes have been identified in epithelial tumors, and BRD4-NUT is the first fusion onco

72 is frequently lost or suppressed in several epithelial tumors, and studies of its cellular function

73 rface glycoprotein has been reported in most epithelial tumors, and the overexpressions of this mRNA

74 mily members are frequently overexpressed in epithelial tumors, and their expression is associated wi

75 In this model, surface epithelial tumors are divided into two broad categories

76 Various epithelial tumors are linked to EGFR overexpression or e

77 Thymic epithelial tumors are rare malignancies, and there is no

78 smembrane glycoprotein, is expressed in most epithelial tumors as a heterodimer consisting of an extr

79 on is an attractive therapeutic strategy for epithelial tumors, as ligand-induced erbB2/EGFR heterodi

80 ategy for the treatment of ovarian and other epithelial tumors associated with elevated levels of EGF

81 ntiation of stratified epithelia and induces epithelial tumors at a high frequency.

82 Gli protein and induces Shh target genes and epithelial tumors at anagen but not other stages, pointi

83 erous cystadenoma (SCA), presenting as large epithelial tumors bearing conspicuous gross and histolog

84 Somatic insertions were present in epithelial tumors but not in blood or brain cancers.

85 to delay the growth kinetic of an aggressive epithelial tumor, but also to shape its histology.

86 ily member Bmi1 is overexpressed in numerous epithelial tumors, but its role in their development has

87 Fbxo7 was highly expressed in epithelial tumors, but not in normal tissues, suggesting

88 eature of the tumor microenvironment in some epithelial tumors, but their role in the malignant progr

89 y by immune cells, may promote the growth of epithelial tumors by mediating increased proliferation a

90 cer cells can also migrate collectively from epithelial tumors by wrapping around vessels or muscle f

91 stasis and establish the concept that K14(+) epithelial tumor cell clusters disseminate collectively

92 L) clones in promoting specific TCR-mediated epithelial tumor cell cytotoxicity.

93 -activated fibroblasts (CAF) that facilitate epithelial tumor cell invasion.

94 Previous work using an epithelial tumor cell line showed that a Chlamydia-speci

95 not the RelB form of NF-kappaB in a mucosal epithelial tumor cell line.

96 the current study, we use the murine mammary epithelial tumor cell lines 4T1 and 4T07; these cells ar

97 We have generated mouse ovarian epithelial tumor cell lines that contain various combina

98 onal regulation of OPN in the murine mammary epithelial tumor cell lines, 4T1 and 4T07, which are sub

99 synthase kinase-3beta inhibition in several epithelial tumor cell lines, and by Snail1 overexpressio

100 Because CML28 was highly expressed in epithelial tumor cell lines, anti-CML28 responses were a

101 expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoi

102 In a panel of human breast cancer and other epithelial tumor cell lines, HER2-overexpressing tumors

103 f centromeric regions that distinguishes the epithelial tumor cell lines.

104 ive gene signature that may be a response to epithelial tumor cell overcrowding.

105 mal transition is frequently associated with epithelial tumor cell progression from a comparatively b

106 disruption of colonic homeostasis, fulminant epithelial/tumor cell proliferation, and activation of t

107 animal model by implanting ER- mouse mammary epithelial tumor cells (CSMLO) in syngeneic A-J mice.

108 Akt1-deficient mammary epithelial tumor cells (MEC) were reduced in size and pr

109 implicated in multiple signaling pathways in epithelial tumor cells and lack of Tiam1 in tumor cells

110 enesis, and homing on target organs) between epithelial tumor cells and neighboring stromal cells, su

111 ancer have focused on genetic changes in the epithelial tumor cells and therefore have not robustly t

112 or cells provides a unique approach to study epithelial tumor cells and to gain an insight into signa

113 nascent tumors grow and undergo progression, epithelial tumor cells are intimately associated with st

114 ses the invasion of breast tumors; moreover, epithelial tumor cells coxenografted with Snail1-deplete

115 lyses of MIC gene 5'-end flanking regions in epithelial tumor cells defined minimal core promoters th

116 Additionally, in vitro analyses of epithelial tumor cells derived from the Apc(1638N/wt);Tg

117 human breast cancer cells and mouse mammary epithelial tumor cells engineered to lack PTPN12 exhibit

118 utaneous inoculation of nude mice with human epithelial tumor cells engineered to secrete corticotrop

119 Expression of WSX1 in epithelial tumor cells enhances NK cell cytolytic activi

120 The SCCs that lacked p53 and alphav in the epithelial tumor cells exhibited high Akt activity, lack

121 We show here that malignant human ovarian epithelial tumor cells express very high levels of strom

122 at both cytokines can have direct effects on epithelial tumor cells expressing appropriate receptors.

123 ted against these peptides specifically lyse epithelial tumor cells expressing Ep-CAM but not normal

124 cells and NK cells against transfectants and epithelial tumor cells expressing MICA.

125 microdissection (LCM) technology to capture epithelial tumor cells from 28 lymph node-negative breas

126 ead T256A mutant Sgk, protected Con8 mammary epithelial tumor cells from serum starvation-induced apo

127 FE can "retarget" adenovirus to CEA-positive epithelial tumor cells in cell culture, in s.c. tumor gr

128 lation of stromal cells that are adjacent to epithelial tumor cells in three mouse carcinoma models (

129 tiate tumor progression by inducing adjacent epithelial tumor cells into EMT.

130 (EMT) is implicated in converting stationary epithelial tumor cells into motile mesenchymal cells dur

131 EMT transforms relatively benign epithelial tumor cells into quasi-mesenchymal or mesench

132 une cells, the antitumor activity of WSX1 in epithelial tumor cells is independent of IL-27 signaling

133 Expression of oncogenic Ras in epithelial tumor cells is linked to the loss of transfor

134 and filtered using the Isolation by Size of Epithelial Tumor cells method.

135 leukemic cells and its stable expression in epithelial tumor cells sensitized to IR.

136 Expression of exogenous WSX1 in epithelial tumor cells suppresses tumorigenicity in vitr

137 rapidly (within 15 minutes) bound to various epithelial tumor cells suspended in cell medium.

138 cells were then compared with findings from epithelial tumor cells that aberrantly express R-ras.

139 Epithelial tumor cells that have undergone epithelial-to

140 xposure of cultured and primary leukemic and epithelial tumor cells to clinically relevant nanomolar

141 l transition (EMT), a key mechanism enabling epithelial tumor cells to disseminate and metastasize.

142 y intercellular junctions which tightly link epithelial tumor cells to each another.

143 activated CD8 T cells can stimulate mammary epithelial tumor cells to undergo epithelial-mesenchymal

144 ess, which involves the dedifferentiation of epithelial tumor cells towards a motile, metastatic, and

145 Epithelial tumor cells transit to a mesenchymal state in

146 To acquire these characteristics, epithelial tumor cells undergo epithelial-to-mesenchymal

147 evel of WSX1 expression in multiple types of epithelial tumor cells when compared with normal epithel

148 Mixing the epithelial tumor cells with Matrigel or primary human ma

149 Thus, interactive forces between CTL and epithelial tumor cells, mainly regulated by integrin eng

150 In Con8 rat mammary epithelial tumor cells, the synthetic glucocorticoid dex

151 In Con8 mammary epithelial tumor cells, we have documented previously th

152 In Con8 mammary epithelial tumor cells, we have previously documented th

153 ry functions, but they are also expressed by epithelial tumor cells, where they have been implicated

154 tly with elevated cytoplasmic eIF3e level in epithelial tumor cells.

155 uclear localization of IKKalpha in prostatic epithelial tumor cells.

156 e latter was especially obvious on malignant epithelial tumor cells.

157 ale embryos and the proliferation of ovarian epithelial tumor cells.

158 previously been shown to be induced on most epithelial tumor cells.

159 a cells, but exerts no such effects on other epithelial tumor cells.

160 eased phosphorylation of p53 on serine-15 in epithelial tumor cells.

161 thelial cells, but downregulated in invasive epithelial tumor cells.

162 er, MICA/B are expressed on diverse cultured epithelial tumor cells.

163 s, where it orchestrates the cross-talk with epithelial tumor cells.

164 potentiates the growth and transformation of epithelial tumor cells.

165 I expression in T cells but represses it in epithelial tumor cells.

166 dedifferentiation of wild-type Pygo2 mammary epithelial tumor cells.

167 hymal cells rely much more on glutamine than epithelial tumor cells; consequently, they are more sens

168 sential for both the excess proliferation of epithelial/tumor cells and the disruption of colonic hom

169 ntrolling key oncogenic programs in both the epithelial tumor compartment and the tumor microenvironm

170 ells from patients with early and late-stage epithelial tumors contain increased proportions of CD4(+

171 e develop ovarian tubular adenomas, a benign epithelial tumor corresponding to surface epithelial inv

172 Therefore, epithelial tumors could survive in the absence of exogen

173 d gives new insight into the pathogenesis of epithelial tumors, demonstrating that the penetrance and

174 genesis has been used to study mechanisms of epithelial tumor development by oncogenic Hras.

175 To examine the function of C/EBPalpha in epithelial tumor development, an epidermal-specific C/EB

176 Several epithelial tumors display epidermal growth factor recept

177 iants, which can be selected for to generate epithelial tumors during metastatic colonization.

178 Many epithelial tumors (e.g., colon, lung, and breast) expres

179 of clinical significance in the treatment of epithelial tumors especially with respect to the enhance

180 , and the impact of, p53 inactivation during epithelial tumor evolution in a transgenic brain tumor m

181 r cell lines derived from breast and ovarian epithelial tumors examined by Western blotting, Dab2 exp

182 applicable immunotherapies for common solid epithelial tumors expressing CEA.

183 dels in identifying causal genetic events in epithelial tumor formation.

184 of epithelial tumors and increased the mean epithelial tumor-free survival time by 38% (P < 0.0001),

185 play an important role in the transition of epithelial tumors from a benign to an invasive state.

186 ers the possibility of monitoring changes in epithelial tumor genotypes during the course of treatmen

187 ells impairs the WSX1-mediated inhibition of epithelial tumor growth.

188 Most human epithelial tumors harbor numerous alterations, making it

189 However, ovarian epithelial tumors have not been documented in p53 homozy

190 Like many epithelial tumors, head and neck squamous cell carcinoma

191 mong peptides eluted from HPV-16-transformed epithelial tumor HLA-A*0201 immunoprecipitates was analy

192 a novel suppressor of cancer progression in epithelial tumors; however, its role in hematologic mali

193 dney is sufficient to induce primitive renal epithelial tumors; however, when compounded with activat

194 melanoma (HR, 0.74; 95% CI, 0.36 to 1.55) or epithelial tumors (HR, 0.89; 95% CI, 0.48 to 1.64).

195 -NKG2D system was proposed to participate in epithelial tumor immune surveillance.

196 reviously reported an increased incidence of epithelial tumors in Fancd2 knockout mice.

197 of autonomous growth and the progression of epithelial tumors in mouse skin.

198 CD25+ lymphocytes inhibit colitis-associated epithelial tumors in Rag-deficient mice.

199 and enzootic nasal tumor virus (ENTV) induce epithelial tumors in the airways of sheep and goats.

200 in the stromal microenvironment can lead to epithelial tumors in the colon.

201 Then, chemically-induced epithelial tumors in the hamster cheek pouch were treate

202 sporadic cancers, such as breast or ovarian epithelial tumors, in the general population.

203 sociated with several types of lymphomas and epithelial tumors including Burkitt's lymphoma (BL), HIV

204 found to be overexpressed in a wide range of epithelial tumors, including breast cancer.

205 ed at significant frequency in various human epithelial tumors, including colorectal cancer, and is s

206 venile development are resistant not only to epithelial tumors, including liver (60-80%) and lung tum

207 ly, we found that LZTFL1 is downregulated in epithelial tumors, including lung cancer, and functions

208 ts in cultured human cell lines derived from epithelial tumors, including prostate and lung carcinoma

209 ucial for the migration and invasion of many epithelial tumors, including prostate cancer.

210 to be frequently hypermethylated in various epithelial tumors, including small cell lung, breast, bl

211 suppressor PTEN are found in many different epithelial tumors, including thyroid neoplasia.

212 d increase in the percentage of fish bearing epithelial tumors, indicating that separase is a tumor s

213 t decreases the incidence and growth of lung epithelial tumors initiated by oncogenic Kras, suggestin

214 uption of cell polarity is a prerequisite in epithelial tumor initiation, the roles of CDC42 in tumor

215 Stimulation of glutamine-driven epithelial tumor invasion by fibroblasts required previo

216 Metastatic progression of most common epithelial tumors involves a heterogeneous, transient lo

217 Cyclooxygenase-2 (COX-2) expression in epithelial tumors is frequently associated with a poor p

218 Because this class of epithelial tumors is generally intractable to currently

219 ssociated with the metastatic progression of epithelial tumors is the dynamic regulation of cadherins

220 Although glandular inversion in epithelial tumors is thought to be a potential mechanism

221 he development and/or progression of various epithelial tumors, is uniformly present in all breast ca

222 involved in T-lymphocyte recruitment within epithelial tumor islets and intratumoral early T-cell si

223 days, sorting cycles, and common across all epithelial tumor lines investigated.

224 NAi) decreased cell motility in four of four epithelial tumor lines tested.

225 Mammalian epithelial tumors lose polarity as they progress toward

226 As serous tumors are the most common surface epithelial tumors, low-grade serous carcinoma is the pro

227 proach to the preparation of variants of the epithelial tumor marker MUC1 carrying one or more Tn, T,

228 mone receptor signaling in the initiation of epithelial tumors may help define this axis as a target

229 apeutically relevant immunity against lethal epithelial tumors may require targeting tumor-induced im

230 rful agent to retarget adenovirus vectors to epithelial tumor metastases.

231 Epithelial tumor metastasis is preceded by an accumulati

232 to decrease tumor size in hematological and epithelial tumor models by interfering with the protecti

233 delta T cells have been observed in various epithelial tumors; moreover, MICA/B are expressed on div

234 Mean ADC value of both readings of thymic epithelial tumors (n = 30) was 1.24 x 10(-3) mm(2)/sec a

235 In the EBV-associated epithelial tumor nasopharyngeal carcinoma (NPC), the vir

236 Conjunctival papilloma is a benign epithelial tumor occurring in both children and adults w

237 olangiocarcinoma (CCA) is a highly malignant epithelial tumor of the biliary tree with poor prognosis

238 We used ovarian epithelial tumors of different malignant potential to lo

239 a major factor in the development of common epithelial tumors of humans, but it extends over decades

240 nstrate the functional expression of CD40 in epithelial tumors of the cervix and support the clinical

241 ceptor gamma (PPAR gamma) gene in follicular epithelial tumors of the human thyroid gland.

242 omeobox gene HOXA7 as encoding an antigen in epithelial tumors of the ovary.

243 Epithelial tumors of the pancreas exhibit a wide spectru

244 eborrheic keratoses (SKs) are common, benign epithelial tumors of the skin that do not, or very rarel

245 These tumors and other epithelial tumors often express both cyclooxygenase-2 (C

246 Epithelial tumors often secrete abundant amounts of the

247 that of seven genes frequently methylated in epithelial tumors, only RASSF1A gene was frequently meth

248 response, which was not detected in cells of epithelial tumor origin, was apoptosis.

249 ssion correlates with good prognosis in some epithelial tumors, our findings may encourage a reevalua

250 Epithelial tumors overexpress MHC class I chain-related

251 nd advanced stages (stage III, IV) of thymic epithelial tumors (P = .006 and .005, respectively).

252 7.5 months in mesenchymal versus 5 months in epithelial tumors (P = .02).

253 spontaneous cancers with a diverse range of epithelial tumors, particularly cutaneous adnexal tumors

254 s with increased overall survival and a more epithelial tumor phenotype in patients with KRAS mutant

255 a functional Brca1 increases murine ovarian epithelial tumor predisposition by increasing estrogen s

256 ased expression of Stat3 downstream genes in epithelial tumor progenitor cells.

257 A hallmark characteristic of epithelial tumor progression as well as some processes o

258 and furthermore that p53 loss can facilitate epithelial tumor progression by a mechanism in addition

259 During epithelial tumor progression, the loss of E-cadherin exp

260 Most epithelial tumors recruit fibroblasts and other nonmalig

261 ely 25% of patients with melanoma and common epithelial tumors, represents an attractive target for i

262 Many epithelial tumors show deletion of the short arm of chro

263 tion of chemical changes in fibroblasts upon epithelial tumor signaling is poorly understood.

264 was reactivated in about 10% (7.1-17.1%) of epithelial tumors (six tumor types, n = 369).

265 otch1 in human cancer, the role of Notch3 in epithelial tumors, such as lung carcinomas, has not been

266 for dissection of cell-specific programs of epithelial tumor suppression.

267 owever, direct evidence for C/EBPalpha as an epithelial tumor suppressor is lacking due to the absenc

268 sensus that they function as cell-autonomous epithelial tumor suppressors.

269 OPC, this mechanism may also apply to other epithelial tumor systems modulated by COX activity.

270 sary to identify low versus high risk thymic epithelial tumors (TETs) before operation to guide optim

271 We analyzed 28 thymic epithelial tumors (TETs) using next-generation sequencin

272 vivo was approximately 1.5 times greater in epithelial tumors than EMT tumors.

273 Ovarian cancer is an aggressive epithelial tumor that remains a major cause of cancer mo

274 , the occurrence of multifocal and recurrent epithelial tumors that are preceded by and associated wi

275 eral, metastatic, multifocal primitive renal epithelial tumors that have the histologic and staining

276 l program for the invasion and metastasis of epithelial tumors that involves loss of cell-cell adhesi

277 signaling to form metastatic primitive renal epithelial tumors that mimic the epithelial component of

278 Craniopharyngiomas are epithelial tumors that typically arise in the suprasella

279 and LMO4-overexpressing mice develop mammary epithelial tumors, the mechanisms involved are unknown.

280 of two oncogenes commonly over-expressed in epithelial tumors: the p53 homologue DeltaNp63alpha and

281 determine whether p53-/- ovaries can develop epithelial tumors, they were transplanted into the ovari

282 st epithelial tissue as compared with breast epithelial tumor tissue.

283 ditioning regimen to enhance the response of epithelial tumors to ALA-PDT, possibly broadening its cl

284 tifying breast cancers and potentially other epithelial tumor types for targeted therapies aimed at t

285 n various normal tissues and multiple common epithelial tumor types.

286 ntibody cetuximab shows activity in multiple epithelial tumor types; however, responses are seen in o

287 The extracellular matrix of epithelial tumors undergoes structural remodeling during

288 echanisms by which STAT3 inhibits intestinal epithelial tumors using Apc(min)(/+)/Stat3(IEC-KO) mice

289 , we analyzed gene expression in 113 ovarian epithelial tumors using oligonucleotide microarrays.

290 nt diffusion coefficient (ADC) of the thymic epithelial tumors was calculated by the same observer at

291 l-to-mesenchymal transition of metastasizing epithelial tumors, we generated citrullinated vimentin p

292 umor-associated fibroblasts and pericytes in epithelial tumors, we set out to investigate the role of

293 gs were similar when borderline and invasive epithelial tumors were considered separately.

294 Epithelial tumors were highly vascularized with tight ce

295 Finally, epithelial tumors were more susceptible to elimination b

296 The frequent downregulation of Rap1GAP in epithelial tumors where alterations in cell/cell and cel

297 CD44 is broadly expressed in hematologic and epithelial tumors, where it contributes to the cancer st

298 Twenty patients with epithelial tumors who underwent high-dose cisplatin lava

299 Neuroendocrine neoplasms (NENs) are rare epithelial tumors with heterogeneous and frequently unpr

300 LF3 is a documented tumor suppressor in many epithelial tumors yet displays oncogenic properties in o