ライフサイエンスコーパス: epitope

1 pY motif and the surrounding folded protein epitope.

2 ce and other nonprimate mammals express this epitope.

3 -1 from N americanus, attached to a T-helper epitope.

4 t lead to the exposure of new IgE - reactive epitopes.

5 lowing for adaption to imperfectly conserved epitopes.

6 ) epitopes while retaining high-affinity mAb epitopes.

7 mbinations that target distinct neutralizing epitopes.

8 ave shown promise is aberrant O-glycoprotein epitopes.

9 on and characterization of T cell-activating epitopes.

10 from past antigens or better exposure of HA epitopes.

11 plays a known role in shielding immunogenic epitopes.

12 c responses to peptides representing diverse epitopes.

13 response away from targeting more protective epitopes.

14 s and recognize various conformational HBsAg epitopes.

15 ed cell membrane and present novel antigenic epitopes.

16 emic coronaviruses, compared with N-terminal epitopes.

17 eutralizing antibodies that target conserved epitopes.

18 inding and subsequent deep sequencing to map epitopes.

19 controlling access to group-determining stem epitopes.

20 et al. shed light on dengue virus 3-specific epitopes.

21 diversity, much of which is found within CD8 epitopes.

22 the absence of immune interference by other epitopes.

23 selective antibodies against relevant viral epitopes.

24 By removing conformational and linear IgE epitopes, a hypoallergenic Ara h 2 mutant with abolished

25 gnizing a mean of 3.1 shared antigen-derived epitopes across HLA-A, B, and C.

26 Heteroclitic Epitope Activated Therapy (HEAT) dispenses with the need

27 iated posttranslational modification perturb epitope affinity for two groups of widely used monoclona

28 We discuss the role of the epitope, affinity and immobilization spacer of PBs as we

29 For VP7 neutralization epitopes, amino acid substitutions observed at positions

30 oncluded that heptasaccharide is the minimal epitope and a potential candidate for the vaccine agains

31 n with fusion proteins containing the Ag 85B epitope and consistently induced isotype switching to th

32 Epitope and paratope mapping revealed few interactions w

33 , the magnitude and positivity for V2 linear epitope and V1V2 proteins were significantly lower in HV

34 erogeneity (ITH) by correlating regional neo-epitope and viral antigen burden with the regional adapt

35 HN3-T20, which was modified to remove T-cell epitopes and contains a PE domain II truncation.

36 evealed multiple distinct and nonoverlapping epitopes and indicated an array of potential neutralizat

37 -Gal epitopes because they express alpha-Gal epitopes and lack anti-Gal Abs.

38 hat mimics humans in that it lacks alpha-Gal epitopes and secretes human anti-Gal Abs.

39 and FHR3 compete with CFH for binding to MDA-epitopes and that FHR1 displays the highest affinity tow

40 shaping the repertoire of presented peptide epitopes and the formation of a hierarchical immune resp

41 amma response when compared to non-conserved epitopes and were restricted to 13 HLA class I genotypes

42 is due to amino acid differences within the epitope, and our attempts to rationally design cross-rea

43 ed the MAb cross-reactivities, localized the epitopes, and measured functional activities as potency

44 III epitope response and induced fusion loop epitope antibodies that are known to facilitate antibody

45 maged hemichannels that were liganded by Fab-epitope antibody fragments via atomic force microscopy.

46 The selected mvPC epitopes are homologous against all currently available

47 Bead-based epitope assay (BBEA) was used to quantitate the levels o

48 y assist high-affinity binding of HIV-1 MPER epitope at membrane interfaces.

49 2 and 4 as well as a novel Art v 3-specific epitope at the C terminus.

50 The generation of MAR-ASD-specific epitope autoantibodies in female mice prior to breeding

51 Fab complex identifies the highly conserved epitope, away from the ACE2 receptor binding site.

52 sponses in NOD mice are dominated by insulin epitope B:9-23 (InsB(9-23)) specificity, and mutation of

53 he efficacy of vaccines expressing alpha-Gal epitopes because they express alpha-Gal epitopes and lac

54 e therefore sought to identify common T cell epitopes between Lassa fever survivors from Sierra Leone

55 on, we confirmed several previously reported epitopes but also identified novel (to our knowledge) ep

56 s 14B10 and NA9D7 recognize broad protective epitopes but only bind the mature virion.

57 munodominant human VP11/12 CD4(+) T(EM) cell epitopes, but not with cryptic epitopes, induced HSV-spe

58 Cross-recognition of viral epitopes by CD8 T cells is associated with viral control

59 ponse either through hindering access to key epitopes by lymphocytes or through altering immune respo

60 Cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) analysis in blood and

61 y to elicit antibodies to non-immunodominant epitopes by vaccination.

62 For 6 epitopes, CD8+ T-cell responses were confirmed in T cell

63 nced RSV isolates demonstrated no suptavumab epitope changes in RSV A isolates, while all RSV B isola

64 e antibody targets, due to pGlu3-Abeta's neo-epitope character and its propensity to form neurotoxic

65 revealed a complex landscape with protective epitopes clustering in at least 6-7 antigenic sites.

66 ook in the understanding of the necessity of epitope clusters for effective mAb recognition.

67 Mapping TCR clones to common viral epitopes (CMV, EBV, and influenza A) demonstrated that A

68 positive (CD8(+)) T cell epitopes, including epitopes common to both Nigerian and Sierra Leonean surv

69 HR1 displays the highest affinity toward MDA-epitopes compared to CFH and FHR3.

70 the structural and functional rationale for epitope conservation, provide insights for development o

71 utions of antibody somatic hypermutations to epitope contacts.

72 s and found that reactivity to classical CCD epitopes (core beta-1,2-xylose, alpha-1,3-fucose) was po

73 1 chain glycosphingolipids (GSLs), with HBGA epitopes corresponding to the geno- and phenotypes of th

74 This GRP, as well as its minimal peptide epitope Crip21, serve as a pathogen-associated molecular

75 ich are unable to present the immunodominant epitope, CSP-based vaccines did not confer complete prot

76 containing a tetanus toxoid universal T-cell epitope (CuMVTT).

77 We used the Immune Epitope Database and Analysis Resource (IEDB) to catalog

78 ecause they were not trained on high-quality epitope datasets covering a broad range of HLA alleles.

79 When equipped with epitope-defined TCRs or chimeric antigen receptors, thes

80 the same self-antigen peptide at comparable epitope densities.

81 sembled monolayers that display tunable CD20 epitope densities.

82 Epitope density has a profound impact on B cell response

83 opeptide oral delivery system using a B-cell epitope derived from the aspartic protease Na-APR-1 from

84 In this study, we tested pools of epitopes derived from dengue (DENV), Zika (ZIKV), Japane

85 We identified three such epitopes derived from highly conserved regions within LA

86 against dominant and subdominant neoantigen epitopes derived from mutations, and leads to an effecti

87 ) T(EM) cells specific to two immunodominant epitopes derived from the HSV-1 tegument protein VP11/12

88 New innovations in epitope design and selection, synthesis, and formulation

89 us-specific neutralizing IgG that recognized epitopes different from those recognized by lower-level

90 sses the recent developments in allergen and epitope discovery, allergy diagnostics and immunotherapy

91 says, and protein chimeras have been used in epitope discovery.

92 ymes were able to hydrolyse the pentapeptide epitopes effectively.

93 identification of naturally presented viral epitopes enabled a comprehensive and systematic assessme

94 CD8 T cells poorly cross-recognized variant epitopes encoding HLA-I-associated adaptations, further

95 ad applications to other antigens beyond M2e epitope evaluated in this study using chicken infection

96 tion in the G614 spike, suggesting increased epitope exposure as a mechanism of enhanced vulnerabilit

97 In mice, the epitope expressed from the gB promoter restored full gB-

98 e retained long term, suggesting that latent epitope expression is sufficient to retain gB-CD8s.

99 called TopoBuilder, with which we engineered epitope-focused immunogens displaying complex structural

100 o improve upon RTS,S, a minimal repeat-only, epitope-focused, protective, malaria vaccine was designe

101 everal important problems, including mapping epitopes, following protein aggregation, locating small

102 We identified the epitope for mAb-EspB-B7 and validated it by competitive

103 The chloroguanide ending of CHX is the main epitope for the IgE and is suitable as screening assay t

104 antibodies reveal the details of a conserved epitope formed by residues in the BC and HI loops of VP2

105 specifically recognise a new conformational epitope formed by two different gangliosides (gangliosid

106 e diabetic mice have been shown to recognize epitopes formed by the covalent cross-linking of proinsu

107 ity to recognize generic aggregation-related epitopes formed by unrelated amyloid sequences.

108 rs that did not display quaternary-structure epitopes found on E dimers and higher-order structures t

109 HSV expressing the epitope from the full latency-associated transcript prom

110 ned to screen for immunoglobulin G targeting epitopes from all known cardiac ion channels with extrac

111 y (PTI) can be activated upon recognition of epitopes from flagellin including flg22.

112 In the present study, we report that several epitopes from the HSV-1 virion tegument protein (VP11/12

113 of these is identical to the HJT-R3-A9 scFv epitope, further suggesting that it is immunodominant.

114 currently available tools to predict T cell epitopes has not been comprehensively evaluated.

115 onoclonal antibodies that bind a pan-amyloid epitope have potential to prevent or eradicate bacterial

116 We identify the glycan epitope high mannose as a marker of influenza virus-indu

117 isplay, that specifically binds to the NPM1c epitope-HLA-A2 complex but not to HLA-A2 or to HLA-A2 lo

118 tration (P < 0.05), whereas the pentapeptide epitopes hydrolysis was influenced only by the actinidin

119 found that all methods were able to improve epitope identification above random, with the best perfo

120 in autoantibody screening were subjected to epitope identification.

121 d recognition, we developed a model of tumor epitope immunogenicity that filtered out 98% of non-immu

122 s a major source for HLA class I autoantigen epitopes implicated in CD8 T cell (CTL)-mediated beta-ce

123 The hybrid epitope imprinting was achieved by electropolymerization

124 Ab1485 binds the V3-glycan epitope in a glycan-dependent manner.

125 to guide mutations in the BG505 glycan hole epitope in an attempt to broaden the reactivity of a B41

126 cells that bear its cognate Tn-glycopeptide epitope in podoplanin, also called OTS8.

127 is study, we identified a novel neutralizing epitope in the head region recognized by a broadly neutr

128 This revealed a universal epitope in VP2N which could be used as a peptide antigen

129 ts' IgE recognized conformational and linear epitopes in a patient-specific manner.

130 es (V(H)Hs) previously reported to recognize epitopes in proximity to RTA's active site.

131 at tumor neoepitopes actually dominate viral epitopes in putative immunogenicity and plausibly drive

132 as well as the enzymatic synthesis of glycan epitopes in the aqueous phase in a single reaction vesse

133 te TRIM/TRIM-like E3 ligases through similar epitopes in the helicase domains.

134 We identified all reactive T cell epitopes in the HIV-1 proteome for each participant and

135 ontrols using VirScan revealed more than 800 epitopes in the SARS-CoV-2 proteome, including 10 epitop

136 ors were primarily active against C-terminal epitopes in the spike protein, which show a higher homol

137 ocompatibility complex (MHC) class I-binding epitopes in the tail length tape measure protein (TMP) o

138 esting that gC hampers the recognition of gB epitopes in the viral particle.

139 Protective mAbs map to exposed epitopes in the wing domain and loop face of the beta-pl

140 cistronic biosensor encoding distinct repeat epitopes in two open reading frames (ORFs), one translat

141 e identified 12 CD8-positive (CD8(+)) T cell epitopes, including epitopes common to both Nigerian and

142 s-reactivity, suggesting that some conserved epitopes, including two conserved arginines, are shared

143 re of these two immunodominant CD4(+) T cell epitopes induced a robust antiviral CD4(+) T cell respon

144 +) T(EM) cell epitopes, but not with cryptic epitopes, induced HSV-specific polyfunctional IFN-gamma-

145 o not support the inclusion of the 5D5 N-CSP epitope into the next generation of CSP-based vaccines.

146 se to recognize several variants of a single epitope is an important consideration for vaccine design

147 a diverse IgM repertoire against VP40 and GP epitopes is observed suggesting occult viral persistence

148 MoAb1 antibody, recognizing the MTX-Man cap epitope, is a novel analyte for active TB detection in p

149 s and may hydrolyze a wide range of peptidic epitopes; it is therefore challenging to identify their

150 ng-targeted high-energy rupture of extracted epitopes (ITEM-THREE), to map the area on the MBP-pfMSP1

151 ng domain that is characterized by a shallow epitope lacking defined binding pockets.

152 pes in the SARS-CoV-2 proteome, including 10 epitopes likely recognized by neutralizing antibodies.

153 Among them, the 10-mer epitope located at the C-terminal end of the signal pept

154 ithout bias for expression of specific tumor epitopes, making this platform applicable to all solid t

155 his the most comprehensive dataset of T cell epitopes mapped in a complex pathogen.

156 We report a facile methodology for rapid epitope mapping of neutralizing antibodies (NAbs) agains

157 Functional epitope mapping of these mAbs and small animal prophylax

158 Epitope mapping showed that this collection of nineteen

159 Epitope mapping suggested that the antibody bound to TNF

160 Epitope mapping was performed by IFN-gamma ELISpot scree

161 eviously developed method, intact transition epitope mapping-targeted high-energy rupture of extracte

162 immunogens should have their cross-reactive epitopes masked, and they should be optimized for elicit

163 ibited by antibody feedback, potentially via epitope masking of the immunodominant PfCSP repeat regio

164 s an Asian ZIKV strain, suggesting that this epitope may optimally induce related B cell clonotypes.

165 The second step involves an "epitope mining" phase, in which a second panel of antibo

166 ther the myelin oligodendrocyte glycoprotein epitope MOG(35-55) or the full-length recombinant human

167 ose antibody response focuses on the plateau epitope near the icosahedral 3-fold axes.

168 Molecular characterization of BsAbs' epitopes not only allows for detailed understanding of t

169 th arginine at 378th position of the cryptic epitope of a Shanghai isolate, hCoV-19/Shanghai/SH0007/2

170 a competitive ELISA targeting a specific neo-epitope of COL6alpha3 and evaluate its associations with

171 emonstrated by imaging DNA-origami tiles and epitopes of cardiac proteins in isolated cardiomyocytes.

172 no precise information on cross-reactive IgE-epitopes of cyclophilins is available.

173 T-cell epitopes of multiple allergens/isoallergens are involved

174 mputationally selected and cysteine modified epitopes of neuron specific enolase (NSE), as-synthesize

175 The epitopes of Pin p 1 were found in alpha-helices and coil

176 that can preserve and present conformational epitopes of protein antigens for induction of neutralizi

177 binding of monoclonal antibodies to specific epitopes of T. b.

178 To better understand functional epitopes of the class 5 adhesins and their ability to in

179 performed structure-based design of several epitopes of the HCV E2 envelope glycoprotein to engineer

180 The epitopes of the major allergen of pine nut, Pin p 1, wer

181 nce of conformational and linear IgE-binding epitopes of the major peanut allergen Ara h 2 and to pro

182 tivated B cells, recognizes a conformational epitope on CD81 that is masked when CD81 is bound to CD1

183 The binding epitope on S harbors a sequence motif unique to SARS-CoV

184 MBL binding occluded the autologous NAb epitope on the B41 IO-NP trimers, which may contribute t

185 porter is based on the exposure of a cryptic epitope on the C terminus of the transmembrane portion o

186 st can be estimated by mapping an antibody's epitope on the respective antigen.

187 design bicyclic peptides to target specific epitopes on disordered proteins.

188 sferase (alpha1,3GT) gene and lack alpha-Gal epitopes on glycosylated proteins, whereas mice and othe

189 identified critical antigenic conformational epitopes on H5 hemagglutinin (HA) from different clades

190 e useful in high-resolution mapping of human epitopes on other Ags and the design of improved therape

191 chain Fvs (scFvs), which recognize different epitopes on sEGFR.

192 g requires binding of antibodies to multiple epitopes on the allergen.

193 potent neutralizing antibodies (nAbs) to two epitopes on the receptor binding domain (RBD) and to dis

194 binding domain (RBD) and to distinct non-RBD epitopes on the spike (S) protein.

195 ycans can also be added to prevent access to epitopes on the surface antigens hemagglutinin (HA or H)

196 exchange monitored by NMR can be used to map epitopes onto folded protein surfaces, but only if the c

197 nique mechanism of recognizing two different epitopes or antigens, have shown potential in various th

198 ed for phosphoflow often affect cell surface epitopes or mAb conjugates, precluding the evaluation of

199 to other herpesviruses, differences in viral epitopes, or differences in procedure as likely explanat

200 9 infection were non-neutralizing and target epitopes outside the RBD.

201 Of note, antibodies directed to epitopes overlapping with those of non-NAbs were absent.

202 integrated approach was developed to map the epitope/paratope of PD-1/nivolumab.

203 for HLA-DQ2.2 additionally requiring gluten epitopes possessing a serine at the P3 position of the p

204 Most T cell epitope prediction tools are based on machine learning a

205 use, and what success rates are possible for epitope predictions when considering a highly controlled

206 18A7 binds to a non-conserved epitope present in all three particles, whereas 14B10 an

207 t-responsive NP further strengthened the CTL epitope presentation and CTL responses.

208 , resolve three bottleneck issues in the CTL epitope presentation pathway: vaccine uptake, phagolysos

209 We also developed epitope-preserving ExCel, which enables imaging of endog

210 ll receptor (TCR) contact residue within the epitope prevents diabetes development.

211 ponding experimentally determined structural epitopes previously inferred from NAb:Env structures.

212 ant major histocompatibility complex class I epitopes proliferated considerably in liver after RHV in

213 data include predicted and validated immune epitopes, promising antibodies, RT-PCR and sequencing pr

214 y system to target proinsulin, a large multi-epitope protein capable of inducing tolerance in a heter

215 on of the complexity of IgE, IgG(4), and IgG epitope recognition at a global, allergome-wide level du

216 In live cell-based assays, LGI1 epitope recognition was examined with patient sera (n =

217 opathy, we investigated the clinical role of epitope-recognition patterns and domain-specific PLA(2)R

218 l anti-PLA(2)R1 antibody levels, but not the epitope-recognition profiles at the time of diagnosis, a

219 membrane fusion and virus infection, and the epitope recognized by h5B3.1 has been structurally defin

220 However, proinsulin epitopes recognized by human CD4(+) T cells have not bee

221 and comprehensively mapped shared antigenic epitopes recognized by tumor-infiltrating T lymphocytes

222 The specific T cell epitopes recognized in an individual are determined by g

223 d dataset that systematically defined T cell epitopes recognized in vaccinia virus (VACV) infected C5

224 FLASH utilizes non-degradative epitope recovery and membrane solubilization to enable t

225 two CD4-induced (CD4i) mAbs for masking nND epitopes, referred to as gp120-CD4i fusion proteins.

226 We identified a fourth epitope region in the CTLD8 domain of PLA(2)R1, which wa

227 embranous nephropathy recognize at least two epitope regions in the N- and C-terminals of PLA(2)R1 at

228 one cleavages exclusively along the putative epitope regions of HA in the presence of the antibody.

229 scribed three autoantibody-targeted PLA(2)R1 epitope regions.

230 : vaccine uptake, phagolysosomal escape, and epitope release.

231 ein interactions featuring intricate binding epitopes remain challenging targets for synthetic inhibi

232 n but, surprisingly, HRV-specific CD8 T cell epitopes remain yet to be identified.

233 Defining discontinuous antigenic epitopes remains a substantial challenge, as exemplified

234 Protein variants with exchanged epitope residues confirmed the antibody-binding sites an

235 sidues using a Cys-reactive label that masks epitope residues, followed by infection of the labeled m

236 ng deep mutational scanning, with a focus on epitope residues, we found that the genetic barrier to r

237 ile the monomer antigens stimulated an EDIII epitope response and induced fusion loop epitope antibod

238 esponse has the potential to direct specific epitope responses to localize to the glycocalyx through

239 e best-characterized coronavirus in terms of epitope responses.

240 ng an immunodominant EFYQSTCSAVSKGYL (F-EFY) epitope restricted to HLA-DR4, -DR9, and -DR11 (combined

241 e provirus types and escaped or unrecognized epitopes similar to that of the other individuals.

242 lico protein structural analysis to identify epitope similarities.

243 we investigated the key assumption of viral epitope similarity driving immune response in the hepati

244 on profiling neoepitopes for reactive viral epitope similarity, have been proposed to predict respon

245 (BBEA) was used to quantitate the levels of epitope-specific (es)IgA, esIgE, esIgD, esIgG(1) , and e

246 ed to identify a combination of antigen- and epitope-specific antibodies that using 3- to 15-month or

247 The HLA-B*57:01-restricted, HIV epitope-specific CD8 T-cell responses showed beneficial

248 High-avidity CBFB-MYH11 epitope-specific T cell receptors (TCRs) transduced into

249 emory CD8(+) T cells, sharing the same HSV-1 epitope-specificities, from infected HLA-A*0201 positive

250 contradicting the hypothesis that PLA(2)R1 "epitope spreading" determines the prognosis of membranou

251 o nonviral tumor-associated antigens through epitope spreading.

252 e coreceptor CD81 to confirm preservation of epitope structure and preferred antigenicity profile.

253 mation is available on the complexity of the epitope structure of most allergens.

254 otection was achieved in the absence of this epitope, substantiating the concept that other antigens

255 itional analysis, we identified a pattern of epitope substitutions in the hemagglutinin (HA) of each

256 is discovery of a second major protective TI epitope supports a model in which uncleaved HA trimers e

257 enous protein is fused with a double (V5-HA) epitope tag at the C-terminus.

258 iously used gene editing to introduce a dual epitope tag into the endogenous allele of each of 11 kno

259 in slices from the knock-in mouse expressing epitope-tagged DAT.

260 Using CHO-7 cells stably expressing epitope-tagged DHCR14 or LBR, we investigated the post-t

261 Here using RNAi, endogenous epitope tagging, immunofluorescence microscopy, and 3D-s

262 To identify the epitopes targeted by clusters of Mtb-specific T cells, w

263 ns, a cataloging and appraisal of the T-cell epitopes targeted in type 1 diabetes was completed over

264 ing monoclonal Fab-spike complex revealed an epitope that blocks ACE2 receptor binding.

265 2-amino acid substitution in the suptavumab epitope that led to loss of neutralization activity.

266 studies revealed that the scFv recognizes an epitope that partially overlaps with angiotensin-convert

267 CHK-263 blocks fusion by binding an epitope that spans across E1 and E2 and locks the hetero

268 rophylactic antibodies and define protective epitopes that can be used in rational vaccine design.

269 protein defines the M type and also contains epitopes that promote opsonophagocytic killing of strept

270 and four out of these contain class I and II epitopes that, to our knowledge, are first described in

271 an adjuvant to enhance processing of vaccine epitopes to APCs.

272 t overlapping sets of Chlamydia-MHC class II epitopes to link inductive and effector phases to genera

273 temperature-dependent loss of conformational epitopes to measure thermostability of GP embedded in vi

274 displaying either ubiquitous or CNS-specific epitopes triggered the formation and expansion of cognat

275 to homologous LTPs revealed three structural epitopes: two partially cross-reactive regions around al

276 dy, we have computationally designed a multi-epitope vaccine using spike glycoprotein of SARS-CoV-2.

277 fter unblinding, a Leishmania cross-reactive epitope was identified and removed from the panel.

278 d that although the pathway structure of the epitopes was broadly preserved across the clinical group

279 hile exposure of CD4-induced (CD4i) non-bNAb epitopes was inhibited.

280 These conserved epitopes were associated with a higher magnitude of IFN-

281 Six optimized CD8(+) epitopes were defined, with peptide-MHC pentamer-positiv

282 Common IgG and IgE epitopes were identified between both allergens.

283 The epitopes were identified by quantitating the phage clone

284 Thirty-nine epitopes were identified, predominantly toward the 3' en

285 Immunodominant B-epitopes were mainly located on the surface of the Nt-fr

286 B/T-cross-reactive epitopes were mapped using milk-specific human sera and

287 d neutralizing influenza virus hemagglutinin epitopes were polyreactive.

288 t three main regions of Pin p 1 containing 5 epitopes were recognized by patient sera IgE.

289 non-synonymous mutations in reactive T cell epitopes were tested for their effect on the size of the

290 efficacy, we selected the 18- most promising epitopes, which were joined together using molecular lin

291 ce of low-affinity monoclonal antibody (mAb) epitopes while retaining high-affinity mAb epitopes.

292 ion may provide structural stability for the epitope, while the substitution G172E probably compensat

293 imental investigations and validation of the epitopes with the potential for stimulating T-cell respo

294 As reliable methods to determine structural epitopes with tightly interacting intact antibodies unde

295 selection of ideal TCRs targeting validated epitopes with well-characterized cancer cell expression

296 The VanS(SC)-binding epitope within vancomycin was mapped to the N-terminus o

297 owever, we also characterized DR3-restricted epitopes within both the B-chain (B16-27 and B22-C3) and

298 but also identified novel (to our knowledge) epitopes within proinsulin, which are presented by HLA c

299 -Ag are key for the presentation of specific epitopes within proteinaceous surface-antigens.

300 l responses, but, to date, only a few T cell epitopes within these proteins have been identified.

301 tibodies against a subset of conserved "core epitopes" within PE/PGRS domains are elicited during ear