ライフサイエンスコーパス: era

1 d 44% received RT (78% in RT era, 28% in PET era).

2 se with a PET-positive scan received RT (PET era).

3 raditional" era) and 2009 and 2013 ("modern" era).

4 omplex of ER-associated protein degradation (ERAD).

5 ) are degraded by ER-associated degradation (ERAD).

6 esponse (UPR) and ER-associated degradation (ERAD).

7 n by the ER--associated degradation pathway (ERAD).

8 cians and patients tailored to the precision era.

9 -3) compared to 68% for status 1A in the pre era.

10 roups would be most impacted in the changing era.

11 e-PDT (1967-2001) era versus PDT (2002-2018) era.

12 s to be an effective strategy in the current era.

13 computing machines in this post-Moore's law era.

14 during the later stages of the pre-Columbian era.

15 sparse avian fossil record from the Mesozoic era.

16 planted in the prevalganciclovir prophylaxis era.

17 e addition of dATP and dGTP opposite 1,N (6)-erA.

18 pathway have ushered in the modern oncology era.

19 tepped into the big-data and high-throughput era.

20 esultant decrease in CCI in the most current era.

21 , ranging from 4.0% to 64.2% in the post-KAS era.

22 or consideration of such interactions during ERA.

23 cs, ushering the field into the phylogenomic era.

24 as proven particularly acute in the COVID-19 era.

25 tially life-saving therapies in the COVID-19 era.

26 a prognostic marker in the pre-immunotherapy era.

27 shed cases occurred during the preantibiotic era.

28 roved in consistency and yield in the modern era.

29 ukaemia in the pre-tyrosine-kinase inhibitor era.

30 f the Ulvophyceae late in the Neoproterozoic Era.

31 ic injection of volcanic gases in the Common Era.

32 mpact mortality and DCGF, even in the modern era.

33 bloc recipients only appeared in the oldest era.

34 iew of management approaches in the COVID-19 era.

35 ty's health aspirations in the post-COVID-19 era.

36 ata to previous findings from the interferon era.

37 ough in associative genomics in the big data era.

38 he recent surge of information in this omics era.

39 s, through the microbiological and molecular eras.

40 p = 0.0445) significantly improved over the eras.

41 follow-up, predominantly in prior treatment eras.

42 le conservation of the link between ERES and ERAS.

43 green angiography were no different in the 2 eras.

44 S and then produce COPI vesicles to generate ERAS.

45 s are older and frailer compared to previous eras.

46 s T2DM SPK listings in the pre- and post-PAS eras.

47 89%, respectively, similar across treatment eras.

48 s (n = 907) undergoing lung resection before ERAS.

49 eview is on Ste24 of the "Post-CAAX-Protease Era."

50 underwent DDKT (96.2% in Era 3% vs 59.1% in Era 1 for cPRA 99.9%+), whereas fewer underwent non-KPD

51 KT, KPD, and non-KPD LDKT for HS candidates (Era 1: January 1, 2009-December 31, 2011; Era 2: January

52 as more than doubled since the preindustrial era(1).

53 well-supported crown birds from the Mesozoic era(12), and is the first Mesozoic crown bird with well-

54 ting list mortality was not different across eras (14.8 vs 14.9 deaths per 100 patient-years pre vs p

55 ms with its role and actions during the Nazi era (1933 to 1945).

56 1-y survival was only observed in the oldest era (1987-1997).

57 s (Era 1: January 1, 2009-December 31, 2011; Era 2: January 1, 2012-December 3, 2014; Era 3: December

58 ecimen adequacy in the personalized medicine era, (2) team-based approaches to ensure specimen adequa

59 ble analysis, hepatectomy in the most recent era 2010 to 2015 was associated with a lower incidence o

60 e in the current era compared with preceding eras (2015-2018 versus 2005-2009, adjusted hazard ratio,

61 timate that for fires burning in the current era (2016) the cooling effect from long-term postfire al

62 d with R-CHOP and 44% received RT (78% in RT era, 28% in PET era).

63 d 99.9%+ recipients underwent DDKT (96.2% in Era 3% vs 59.1% in Era 1 for cPRA 99.9%+), whereas fewer

64 11; Era 2: January 1, 2012-December 3, 2014; Era 3: December 4, 2014-December 31, 2017).

65 L-HRD1 complex, the most conserved branch of ERAD(4), is highly expressed in HSCs.

66 In the postvaccine era, a biennial pattern of rotavirus rates was observed,

67 adation protein 1), and is necessary for the ERAD activity of the Sel1L-Hrd1 complex.

68 fluoroquinolone-based SBP prophylaxis in an era and area of frequent antibiotic resistance.

69 ed patients in the directly acting antiviral era and explore the mechanisms through which HIV itself

70 of those who led the society during the Nazi era and on the involvement of high-ranking members in me

71 in the Romanian orphanages of the Ceausescu era and then, subsequently adopted by UK families; 67 Ro

72 d a survey to review practice in the current era and to compare this with results from a 2006 survey.

73 ly categorize climate states of the Cenozoic era and to study their dynamics.

74 continue to progress through the postgenomic era and towards deeper mechanistic insight and clinical

75 are key components of successful colorectal ERAS and surgical site infection (SSI)-reduction program

76 rations between 1999 and 2003 ("traditional" era) and 2009 and 2013 ("modern" era).

77 Enhanced Recovery After Surgery (ERAS) and various derivative ERPs have been successfully

78 ida panhandle since at least 1851 CE (Common Era), and it resulted in the loss of 59 lives and $25 bi

79 stress, promotes ER-associated degradation (ERAD), and reduces IRE1 signaling in the UPR pathway.

80 pushed brain development into the "big data" era, and that current and future transversal approaches

81 nd reprioritize investments for the COVID-19 era, and will necessitate data-driven decision making, p

82 ts, the use of HCV-viremic grafts in the DAA era appears to be efficacious and well tolerated.

83 ns in terrestrial ecosystems of the Mesozoic era (approximately 252-66 million years ago), but their

84 ) liver transplant recipients in the current era are incompletely defined.

85 The dynamics of ERES and ERAS are indistinguishable, indicating that these struct

86 esponse (UPR) and ER-associated degradation (ERAD) are the primary ER quality control mechanism.

87 esponse (UPR) and ER-associated degradation (ERAD) are the primary mechanism that maintains ER protei

88 During the Mesozoic era (around 250 million to 65 million years ago), body s

89 roach is equally beneficial to nano-specific ERA as for other classes of chemicals.

90 Our study defines ERAD as an essential proteostasis mechanism to safeguard

91 ndoplasmic reticulum-associated degradation (ERAD) as a protein quality checkpoint that controls the

92 Risk of death declined over successive eras, at all periods post-transplant.

93 spectrometry approaches, we showed that this ERAD branch is defined by an ER membrane complex consist

94 genome-wide library screen, we identified an ERAD branch required for quality control of a subset of

95 Our data reveal that ERAD branches have remarkable specificity for their memb

96 The laparoscopic era brought about a decline in the conventional surgical

97 also found that RNase H2 recognizes 1,N (6)-erA but has limited incision activity across from this l

98 e presence of damaged ribonucleotide 1,N (6)-erA but has poor RNA primer extension activities.

99 devices in the fifth-generation (5G) network era, but only conventional metals meet the requirements

100 he mechanisms of specific E2/E3 interplay in ERAD, but also offers a basis to understand how RING E3s

101 In the modern direct-acting antiviral era, calculated likely KDPI overestimates risk kidneys f

102 ER arrival sites (ERAS) can be visualized by labeling COPI vesicle tethers

103 the second to eighth centuries of the common era (CE).

104 t were 20% less likely to die in the current era compared with preceding eras (2015-2018 versus 2005-

105 Although ERAD components involved in degradation of luminal subst

106 ncreasing folding capacity and up-regulating ERAD components that remove non-native proteins.

107 new versus experienced surgeons within each era, controlling for the hospital, operation, and patien

108 019 (COVID-19) patients and 190 pre-COVID-19 era controls using VirScan revealed more than 800 epitop

109 Mice with ERAD deficiency in brown adipocytes were cold sensitive

110 gated in the endoplasmic reticulum following ERAD deficiency.

111 After treatment, patients in the PDT era demonstrated better mean logarithm of the minimum an

112 nd reducing its incidence is central to both ERAS development and to the evidence-base for minimally

113 The positive post-DAA era effect was observed only in HCV patients with first

114 The modern era elevated odds of mortality were not significant [OR

115 al assigned ambulatory anorectal patients to ERAS (experimental) or routine care (surgeon's choice) f

116 at least three times throughout the Mesozoic era, explaining the bias towards eggshells of derived di

117 trategies that have been used in the genomic era for natural product discovery from cultivatable bact

118 Humanity will soon define a new era for nature-one that seeks to transform decades of un

119 ion of prediction algorithms represent a new era for noninvasive biomarker discovery.

120 The Sel1L/Hrd1 ERAD genes are enriched in the quiescent and inactive HS

121 ndoplasmic reticulum-associated degradation (ERAD) governs the function of quiescent HSCs.

122 Average daily pain scores were lower in the ERAS group (median 1.3 vs 1.8, P = 0.004); however, this

123 sics used postoperatively was greater in the ERAS group (median 3 vs 2, P < 0.001).

124 s used in 66% of controls and in none of the ERAS group (P < 0.001).

125 ion in morphine milligram equivalents in the ERAS group whether tramadol was included (median 14.2 vs

126 A new era has arrived for investigation of the thin filament a

127 the past 4 years, restoring hope that a new era has dawned in oligonucleotide/siRNA clinical therape

128 Consistent with the trend of that era, Huisgen was the sole author of most of his Review a

129 Here we use preindustrial-era ice core (14)CH(4) measurements to show that natural

130 ency specifically in oligodendrocytes caused ERAD impairment, the UPR activation, and attenuation of

131 al tracking technology have ushered in a new era in biologging.

132 such GC-MRR measurements may initiate a new era in biosynthetic/degradation and geochemical isotopic

133 In this new era in cancer genomics, discoveries from studies conduct

134 amaged and unrepaired ribonucleotide 1,N (6)-erA in DNA exhibits mutagenic potential and can also alt

135 Big data era in genomics promises a breakthrough in medicine, but

136 cade ago marked the beginning of an exciting era in human tumor virology.

137 omarkers in transplantation represents a new era in patient management, it is important for clinician

138 These papers herald a new era in Ras research, with improved drugs and strategies

139 ing, and material science have boosted a new era in the design of robust and sensitive biosensors.

140 pant was recently approved and heralds a new era in the treatment of migraine.

141 over the past two decades, bringing forth an era in which more than a dozen therapeutic agents are no

142 t the present work heralds the dawn of a new era in which neural network-based reactive MD simulation

143 We are in an era in which the assembly pathways of most intracellular

144 ior genetics have evolved in the postgenomic era in which the human genome can be directly measured.

145 can-mediated process, can also contribute to ERAD in an unconventional, catalysis-independent manner.

146 explored the role of the integrated UPR and ERAD in oligodendrocytes in regulating myelin protein pr

147 this study imply that the integrated UPR and ERAD in oligodendrocytes maintain myelin thickness in ad

148 AS) protocols, but little work has evaluated ERAS in these cases.

149 ndoplasmic reticulum-associated degradation (ERAD) in response to the catalytic removal of terminal a

150 , indicating that the ubx4Delta phenotype is ERAD-independent.

151 re still efficacious in the post-reperfusion era is currently debated in the light of recent controve

152 frame in an mRNA transcript because 1,N (6)-erA is incompletely incised by RNase H2.

153 ERAD-L is mediated by the Hrd1 complex (composed of Hrd1

154 esults, suggest how a polypeptide loop of an ERAD-L substrate moves through the ER membrane.

155 N; more ER-associated degradation of alpha3 (ERAD); larger differences in Na,K-ATPase subunit distrib

156 y behaviour of the NAO throughout the Common Era, likely via solar forcing.

157 007); however, when stratified by transplant era, lower 1-y survival was only observed in the oldest

158 We live in a research era marked by impressive new tools powering the scientif

159 than or equal to 8.0% treated in the second era, mean blood glucose greater than or equal to 180 mg/

160 ic reticulum-associated protein degradation (ERAD), membrane proteins are ubiquitinated, extracted fr

161 ndoplasmic reticulum-associated degradation (ERAD), mitochondrial-associated degradation (MAD), chrom

162 In the rituximab era, none of the clinical risk scores identified a patie

163 Traditional era odds of 30-day mortality among matched patients trea

164 relationships, providing the basis for a new era of "ensemble-function" interrogation of enzymes.

165 Kidney research is entering an era of 'big data' and molecular omics data can provide c

166 to the twentieth century, largely within the era of antibiotic usage.

167 Furthermore, in this era of assisted reproductive technologies, understanding

168 he success of machine learning models in the era of big data.

169 laid the foundation for the recent exciting era of cancer immunotherapy, which includes immune check

170 er to bring about food policy changes in the era of climate disruption and environmental degradation.

171 In the era of contemporary immunosuppression and valganciclovir

172 y provide a blueprint for managing LTx in an era of continued community prevalence.

173 In this era of data science-driven bioinformatics, machine learn

174 A new era of data-model integration requires investment in acc

175 echnologies have recently fueled an exciting era of discovery in the field of chromosome structure an

176 very point in space, as well as usher in the era of drone-to-ground and drone-to-drone communications

177 er, this approach has evolved in the current era of drug development, with multiple other development

178 terial surfaces, particularly in the current era of emerging antibiotic resistance.

179 ew and novel antibacterial therapies in this era of emerging antibiotic resistance.

180 As a new-era of energy harvesting technology, the enhancement of

181 l diversity and phenotype resolution in this era of ever-growing genome-wide association studies.

182 etroviral therapy (ART) initiation during an era of expanding HIV testing and treatment efforts.

183 In this era of exponential data growth, minimizer sampling has b

184 , the transition period (2009-2010), and the era of FFDM (2011-2016) were compared.

185 of future high frequency electronics in the era of fifth-generation wireless communication.

186 osts of immunosuppressant medications in the era of generic equivalents may inform immunosuppressant

187 n also guide biodiversity conservation in an era of global change.

188 shape thermal niche width is critical in an era of global change.

189 In the era of global surgery and increasing complexity of surgi

190 systematically evaluates IEps in the modern era of heart transplantation at Stanford University Medi

191 ting antivirals (DAAs) have ushered in a new era of hepatitis C treatment with potential to eliminate

192 time, it may offer the opportunity for a new era of HIV management.

193 ot comprehensively documented in the current era of immunosuppression and prophylaxis.

194 cal trials demonstrating that, in the modern era of improved guideline-directed medical therapies, im

195 In an era of increased complexity of clinical research, a dema

196 omarker monitoring may pave the way into the era of individualized risk assessment and objective deci

197 In the era of information overload, natural language processing

198 ich will soon revolutionize our lives in the era of Internet of Things.

199 n for distributed on-body electronics in the era of Internet of Things.

200 In an era of large-scale science-related challenges and rapid

201 ion of this complex organelle, opening a new era of mitochondrial research.

202 Key issues faced by hematologists in this era of new drugs include (1) the timely identification o

203 ntly, CRISPR-Cas technology has opened a new era of nucleic acid-based molecular diagnostics.

204 In the era of opioid abuse epidemics, there is an increased dem

205 creasing use of eHealth has ushered in a new era of patient-centred cancer care that moves beyond the

206 oadjuvant (presurgical) immunotherapy in the era of PD-1 pathway blockade, highlighting particular co

207 is of biliary tract cancer, especially in an era of personalised medicine, many questions are yet to

208 In the current era of personalized medicine, national and international

209 Dentistry has entered an era of personalized/precision care in which targeting ca

210 In an era of pervasive anthropogenic ecological disturbances,

211 to a broader community, thus allowing a new era of photon democracy.

212 light on the role of higher education in an era of political polarization.

213 que for improving cancer theranostics in the era of precision medicine.

214 in a more personalized manner, entering the era of precision medicine.

215 nd highlight their clinical relevance in the era of precision medicine.

216 that becomes more directed in this evolving era of precision medicine.

217 Technological advances have opened a new era of precision molecular medicine to reprogram cellula

218 In the era of precision oncology, liquid biopsy techniques, esp

219 In the era of prophylaxis, Pneumocystis pneumonia has become a

220 human pathologies, paving the way for a new era of RAMP-targeted drug development.

221 In an era of rapid global change, our ability to understand an

222 ward monitoring physiological signals in the era of real time and portable healthcare systems.

223 lenges facing the treatment of stroke in the era of reperfusion therapy: hemorrhagic transformation a

224 metastasis-directed therapy, in the current era of sequential multimodal therapy incorporating novel

225 Screening outcome in the era of SFM (1997-2008), the transition period (2009-2010

226 This new era of surface science emerged and spread rapidly after

227 ing may be of even greater importance in the era of the COVID19 epidemic, when sleep labs were closed

228 However, with the opening of this new era of treatment, limitations of the current possibiliti

229 ultispecialty practices is increasing in the era of value-based payment.

230 ical practice and research, especially in an era of very large sample sizes, often ignore the develop

231 interpretation of structural variants in the era of whole-genome sequencing.

232 certain whether this risk has changed in the era of wider diagnosis rates, less severe clinical disea

233 evalonate-derived products owing to enhanced ERAD of HMGCR rather than from reduced synthesis of MK-4

234 350 elite inbred lines representing multiple eras of germplasm from both China and the United States.

235 During the Anthropocene and other eras of rapidly changing climates, rates of change of ec

236 days and 90 days to 1 year) and in different eras of transplantation (1995-2005 and 2006-2016).

237 asmic reticulum (ER)-associated degradation (ERAD) of ubiquitinated HMG CoA reductase (HMGCR), the ra

238 three 10-y intervals to assess the effect of era on outcomes.

239 aged analog 1,N (6)-ethenoadenosine (1,N (6)-erA) on translesion synthesis (TLS), mediated by human D

240 chnologies in the current Internet-of-Things era, on-chip energy harvesting is highly attractive, and

241 ical sequences generated in the post-genomic era, one of the most challenging problems in bioinformat

242 e second most active summer in the satellite era; only 5 TCs that occurred during September-October (

243 did not occur in yeast strains in which key ERAD or proteasomal pathway genes had been disrupted, in

244 hange from the traditional era to the modern era [OR 0.93; 95% CI (0.83-1.05), P = 0.233].

245 y by either time to surgical explant or TAVR era, or between patients with versus without endocarditi

246 of either COPII or COPI components disrupts ERAS organization.

247 increased from 17 to 19 days in the post-DSA era (P = .01).

248 Implementation of an ERAS pathway was associated with effective post-operativ

249 recognized by the ER-associated degradation (ERAD) pathway for removal.

250 though oxidative protein folding and the UPR/ERAD pathways each are well-understood, very little is k

251 A major component ERAS pathways is opioid-sparing analgesia; however, the

252 cases] vs. PDT [n = 238 cases]) revealed PDT era patients were of older mean age (48.9 vs. 53.8 years

253 Comparing era, post-LT mortality improved for HCC (adjusted HR, 0.

254 An ERAS protocol in ambulatory anorectal surgery is feasibl

255 al intake, which is an essential part of the ERAS protocols, remains a matter of debate.

256 Elements of enhanced recovery after surgery (ERAS) protocols have been successfully introduced in pat

257 inherent in enhanced recovery after surgery (ERAS) protocols, but little work has evaluated ERAS in t

258 In the modern era, racial and sex disparities in mortality and postope

259 During the prebiotic era, radiolytic transformations in the oceans played a k

260 The Neoproterozoic Era records the transition from a largely bacterial to a

261 ntial for building checklists in the digital era: reliance on online taxonomic resources alone would

262 litical power in Europe during the Neolithic era remains poorly understood(1).

263 When adjusted, the post-DAA era represented an independent positive predictive facto

264 0.28% and 0.14% in the early and newer TAVR era, respectively.

265 central roles played by women in many of the era's discoveries.

266 or to COVID-19's emergence, plus 64 pandemic-era samples from SARS-CoV-2 PCR-negative patients with r

267 In the modern genomic era, scientists without extensive bioinformatic training

268 In the post drug-eluting stent era, studies of racial disparities CABG are outdated.

269 regulator of HSC identity(5), as a bona fide ERAD substrate that became aggregated in the endoplasmic

270 is gated by autoubiquitination and a soluble ERAD substrate.

271 s the channel that mediates the transport of ERAD substrates to the cytosol.

272 framework for environmental risk assessment (ERA) that ideally builds on methods established for conv

273 licable information carrier of the prebiotic era-that is, prior to the dawn of life(2,3)-other eviden

274 In the genomics era, the availability of large biomedical datasets with

275 In this 'big data' era, the research community has identified a significant

276 Since the early days of the genome era, the scientific community has relied on a single 're

277 With the advent of the Genomics Era, there is an unprecedented opportunity to address th

278 of the martian climate from the wet Noachian era to the dry Hesperian (4.1-3.0 Gya) likely resulted i

279 id not appear to change from the traditional era to the modern era [OR 0.93; 95% CI (0.83-1.05), P =

280 ared to the incidence rate in the interferon era (using data from the European Acquired Immunodeficie

281 es were 2-3oC warmer than the pre-industrial era, using output from the Pliocene Model Intercompariso

282 Here we report a multicenter "modern-era" validation study that included 99 patients with def

283 emangioma managed in the pre-PDT (1967-2001) era versus PDT (2002-2018) era.

284 These trends during the COVID-19 era warrant further investigation to address unmet needs

285 patients, receiving a re-LT in the post-DAA era was associated with improved patient and graft survi

286 A new era was marked by the recent isolation of acid-base free

287 In this new era, we are finally able to understand eye development i

288 d impact of post-KT infections in the modern era, we used United States Renal Data System (USRDS) dat

289 nty-eight percent of transplants in the post era were for the most medically urgent (statuses 1-3) co

290 9 (COVID-19) cases and from the pre-COVID-19 era were tested for IgG, IgA, and IgM to the antigen pan

291 Two eras were defined: pre-DAA (2009-2012) and post-DAA (201

292 The urgency is more obvious in the big data era when GWAS are conducted simultaneously for thousand

293 We are now in an era where protein-DNA interactions have been experimenta

294 y relevant as we approach the postmicrobiome era whereby studying the spatial structure of the pathog

295 dation-reduction cycles and may also enhance ERAD, which requires reduced protein substrates.

296 including family planning-by 2030 in the SDG era with its emphasis on 'leaving no one behind.'

297 reak in Israel, in the 13-valent PCV (PCV13) era, with focus on Sp2 population structure and evolutio

298 ates of limited-stage DLBCL in the rituximab era, with the best NCTN results in this disease subset.

299 era (years 2008-2016) versus the pre-Impella era (years 2004-2007).

300 utcomes and costs were higher in the Impella era (years 2008-2016) versus the pre-Impella era (years