ライフサイエンスコーパス: eradicate

1 implanted medical devices, are difficult to eradicate.

2 ore prolonged, complicated, and difficult to eradicate.

3 nosa infections are notoriously difficult to eradicate.

4 ifficult Gram-negative bacteria to treat and eradicate.

5 metastases might be cured if all lesions are eradicated.

6 ART), HIV persists in its hosts and is never eradicated.

7 . stomatis was internalized, it was promptly eradicated.

8 nce all types of wild polioviruses have been eradicated.

9 edators are historically absent, present, or eradicated?

10 n islands from which invasive predators were eradicated ~11 years previously, FID was also higher tha

11 er of effector memory T cells and completely eradicates 4T1 tumors in mice.

12 We assessed the feasibility of eradicating 60 new (not yet established) and 35 emerging

13 Consequently, EDA-KO pigs failed to eradicate a bacterial challenge in lung regions normally

14 se of a single antifluorescein CAR T cell to eradicate a diversity of antigenically different solid t

15 nvestments have been made, over 30 years, to eradicate a human pathogen from the world for the second

16 opulation, TRBC-targeted immunotherapy could eradicate a T cell malignancy while preserving sufficien

17 Precision targeting of mutated gene sets eradicated a large fraction of established tumors at bot

18 of neutrophils and play an important role in eradicating A. baumannii infection in vivo Our findings

19 infected with 100x MLD(50) virus is shown to eradicate advanced infections from representative strain

20 r Ablation to Eliminate Atrial Fibrillation (ERADICATE-AF) trial was an investigator-initiated, multi

21 al threat and are exceptionally difficult to eradicate after they become abundant in their new habita

22 ls, restoring normal human hematopoiesis and eradicating aggressive pathologic MDS cells.

23 rodrug in the designed sequence and timeline eradicated all intraperitoneal tumors and provided survi

24 ropyl alcohol (e.g., alcohol wipes or soaks) eradicated all viable virus.

25 ses numbers of memory CD4+ and CD8+ T cells, eradicating all detectable tumor.

26 cle and temperatures of approximately 300 K, eradicating all forms of life.

27 Eradicating all melanoma cells even in drug-sensitive tu

28 ibitor (TKI) treatment was more effective in eradicating ALL than treatment with a TKI (nilotinib) al

29 eting of CSCs will therefore be necessary to eradicate and cure cancer.

30 ment of 808 nm laser irradiation, tumors are eradicated and no recurrence is observed.

31 In addition, DLPFC virtual lesion eradicated any modulation of motor resonance.

32 biota transplantation (FMT) could be used to eradicate ARB in humans.

33 utralization reduces but does not completely eradicate asthma exacerbations.

34 clear that targeting these pathways does not eradicate asthma symptoms and exacerbation risk; further

35 While numerous invertebrate lineages were eradicated at the last major mass extinction boundary, t

36 amyloid epitope have potential to prevent or eradicate bacterial biofilms.

37 ed bactericidal compounds have been shown to eradicate bacterial lawn biofilms through electroceutica

38 t indigenous microbiota and commonly fail to eradicate bacterial spores, two key factors that allow r

39 re-forming antibiotic polymyxin B completely eradicates bacterial growth.

40 acterial biofilm infections are difficult to eradicate because of antibiotic insusceptibility and hig

41 rococci are opportunistic pathogens, hard to eradicate because of their unusually robust resistance t

42 upport the hypothesis that AMF exposures can eradicate biofilm on metal implants, and may enhance the

43 t lytic agent that is rapidly bacteriolytic, eradicates biofilms, and synergizes with antibiotics.MET

44 eat impact on efforts to prevent, treat, and eradicate both of these important global epidemics.

45 py (SYMPHONY) having the potential to safely eradicate both primary tumors and distant metastatic foc

46 inhibitors in diminishment of breast CSCs to eradicate breast cancer.

47 o eliminate a majority of infected cells and eradicate briskly spreading HSV-2 infection.

48 not all types of wild polioviruses had been eradicated, but it might increase the cost of OPV withdr

49 ating diseases in human history until it was eradicated by a worldwide vaccination campaign.

50 We previously showed that CMT167 tumors are eradicated by anti-PD1 therapy, whereas LLC tumors are r

51 9 expression in solid tumors, which are then eradicated by CD19-specific CAR-T cells in immunodeficie

52 Two pan-resistant Klebsiella isolates were eradicated by combinations targeting multiple heteroresi

53 ML, highlighting the need to therapeutically eradicate cancer cells across a range of differentiation

54 e activates immune responses that target and eradicate cancer cells.

55 enerated from a polymerization initiator for eradicating cancer cells.

56 nly SODs, and deletion of one of them, SOD5, eradicated candidal biofilms on venous catheters in a ro

57 ed cases as opposed to in only 10% (4/42) of eradicated cases (P < 0.001).

58 combination with JAK2 inhibition could thus eradicate cells harbouring mutations in JAK2.

59 rther improvements in efficacy are needed to eradicate challenging refractory tumors, such as gliobla

60 rapeutic potential of 5-FU and irinotecan to eradicate chemotherapy-resistant metastatic human tumors

61 The ideal future goal of treatment is to eradicate chronic HBV infection globally.

62 Despite great efforts to eradicate chronic viral infections, they still remain a

63 hibition of PTN has therapeutic potential to eradicate CML stem cells.

64 ilotinib led to complete disease control and eradicated CML xenograft tumours without recurrence afte

65 tochondrial protein translation, selectively eradicates CML LSCs both in vitro and in a xenotransplan

66 otential therapeutic targets for selectively eradicating CMLSCs.

67 Azithromycin eradicated colonisation in 48 hours in 88% of colonised

68 Azithromycin eradicated colonization in 48 hours in 88% of colonized

69 local pH changes can be reduced but are not eradicated completely.

70 V investigation, development of treatment to eradicate covalently closed circular HBV DNA, and develo

71 ism of pan-EGFR inhibitor and its ability to eradicate CSC may serve as a tailor-made approach to enh

72 ng C1572 as a promising therapeutic agent to eradicate CSCs for drug-resistant TNBC treatment.

73 for therapeutic strategies that specifically eradicate CSCs or induce their differentiation.

74 as used to test a novel compound (PAWI-2) to eradicate CSCs.

75 mor heterogeneity is based on the concept of eradicating CSCs to prevent tumor relapse and therapy re

76 lutionarily conserved catabolic process that eradicates damaged and aging macromolecules and organell

77 both haplotypes, complicating strategies to eradicate deleterious alleles or stack beneficial allele

78 l that combined ibrutinib with venetoclax to eradicate detectable CLL with the intention of stopping

79 endent regulation of CML LSCs is required to eradicate disease.

80 Therefore, research focused on eradicating disease and optimizing clinical management i

81 and that comprises potential drug targets to eradicate dormant myeloma cells.

82 inhibitors is a viable clinical strategy to eradicate DTCs and prevent metastasis.

83 shortfall risk occurs: winter shortfalls are eradicated due to reduced building heating demands, whil

84 rom reinfection when patients in whom HCV is eradicated during treatment become infected with a new H

85 i-Mg and Ti-Mg-3wt% Zn) that can selectively eradicate E. coli while not harming the survival rate, d

86 potential of this phage and show that it can eradicate E. faecalis biofilms formed in vitro on a stan

87 cific cytotoxic T-lymphocytes (EBV-CTLs) can eradicate EBV-associated lymphomas (EBV-PTLD) after tran

88 In order to control and eradicate epidemic cholera, we need to understand how ep

89 It has proven possible to eradicate epidemic diseases, often without the availabil

90 infections had previously been successfully eradicated (eradication group) were 160.52 and 51.60 per

91 ally demonstrated that the immune system can eradicate established cancers and enhance patient surviv

92 y reversal and viral clearance strategies to eradicate established HIV infection.

93 ing antibodies synergize with gemcitabine to eradicate established pancreatic tumors in a syngeneic,

94 both innate and adaptive immune effectors to eradicate established tumors.

95 tic and when combined with chemotherapy, and eradicated established AML even in the absence of a defi

96 stically with checkpoint blockade therapy to eradicate existing glioblastoma.

97 e recognizing developing countries' right to eradicate extreme poverty.

98 ompared to the reference mitigation pathway, eradicating extreme poverty increases the effort by 2.8%

99 We find that eradicating extreme poverty, i.e., moving people to an i

100 sbiosis and systemic inflammation in CKD, we eradicated facultative anaerobic microbiota with antibio

101 uman fibroblasts into motor neurons by first eradicating fibroblast identity and promoting uniform tr

102 Eradicating food insecurity is necessary for achieving g

103 systems for inhibiting biofilm formation and eradicating formed biofilms.

104 yia hominivorax (Coquerel), was successfully eradicated from the United States by the sterile insect

105 eatment of smallpox, a disease that has been eradicated from the world for nearly 40 years, required

106 If it is not eradicated from the wound, it translocates to the bloods

107 lopment, will be essential to containing and eradicating future pandemics.

108 Silencing AVIL nearly eradicated glioblastoma cells in culture, and dramatical

109 ant and is a promising treatment regimen for eradicating HCV in this patient population.

110 n the effectiveness of standard therapies to eradicate Helicobacter pylori infection.

111 ells have demonstrated tremendous success in eradicating hematologic malignancies (e.g., CD19 CARs in

112 The global plan to eradicate hepatitis C virus (HCV) led by the World Healt

113 Ledipasvir-sofosbuvir is effective at eradicating hepatitis C virus (HCV) infection in the gen

114 ral (DAA) regimens are safe and effective at eradicating hepatitis C virus (HCV) infection.

115 and homing to CXCL9/10-expressing tumours to eradicate HER-2(+) mammary tumours in vivo.

116 richment of alphavbeta3 and TAMs to not only eradicate highly aggressive drug-resistant human lung an

117 Here we show an approach to eradicate HIV infections by selective elimination of hos

118 Our results suggest a strategy to eradicate HIV infections by selectively eliminating host

119 rance of this reservoir will be necessary to eradicate HIV-1 in infected individuals.

120 adoptive transfer may support strategies to eradicate HIV-1 infection or to safely deescalate antire

121 nt is required because existing drugs do not eradicate HIV-infected cells.

122 damental limitation to CAR-T cell therapy to eradicate HIV.

123 retroviral therapy ameliorates HIVAN without eradicating HIV from the kidneys and the mechanism by wh

124 rategies currently in development succeed in eradicating HIV reservoirs in peripheral blood and lymph

125 voirs are considered the primary obstacle to eradicating HIV-1 from patients, and multiple strategies

126 ost effective antibodies for controlling and eradicating HIV-1 infection would likely have the dual c

127 ens to overcome resistance to treatments and eradicate HNSCC metastasis.

128 aemopoietic stem-cell transplantation (HSCT) eradicates host haemopoiesis before venous infusion of h

129 Antiretroviral therapy (ART) cannot eradicate human immunodeficiency virus (HIV) and a rapid

130 an studies seeking to induce remission of or eradicate human immunodeficiency virus infection.

131 production sectors, could play a big role in eradicating hunger, malnutrition and nutrient-deprivatio

132 e of cattle that is difficult to control and eradicate in part due to the costly nature of surveillan

133 When rinderpest virus (RPV) was declared eradicated in 2011, the only remaining samples of this o

134 lymphocytes are effector CD8(+) T cells that eradicate infected and malignant cells.

135 s which do not prevent initial infection but eradicate infected cells before infection becomes establ

136 onding resident macrophages phagocytosed and eradicated infecting mycobacteria, suggesting that to es

137 including drug resistance and the failure to eradicate infection highlight the need to identify new p

138 ng granulomas develop rapidly and eventually eradicate infection.

139 nduced cell-mediated immune responses rarely eradicate infection.

140 des, vaccination has been key to prevent and eradicate infectious diseases.

141 pre-existing Allee effects and consequently eradicate insect pests.

142 n vivo by cobalt protoporphyrin-IX treatment eradicated intestinal inflammation and fully protected K

143 transform the malaria community's ability to eradicate it globally.

144 formation of a biofilm and the difficulty to eradicate it.

145 Eradicating JD is a difficult task due to the long incub

146 e, CBD-IL-12 potently synergized with CPI to eradicate large established melanomas, induced antigen-s

147 ll yield, this method licensed Th17 cells to eradicate large tumors to a greater extent than cells ex

148 oral delivery of HMGN1 and R848 plus Cytoxan eradicated large established CT26 tumors.

149 led both cancer cells and tumor vasculature, eradicating large established tumors and metastases, and

150 tegies are being clinically tested either to eradicate latent HIV reservoirs or to achieve virologic

151 Strategies to eradicate latent infection can only be evaluated with ro

152 ty may be especially important to efforts to eradicate latently infected cells.

153 fficacy owing to an inability to effectively eradicate leukaemia stem cells (LSCs)(1).

154 a cells, and is thus a potential approach to eradicate leukemia stem and progenitor cells that are re

155 In vivo, Fas-4-1BB ACT eradicated leukemia and significantly improved survival

156 nd implies that approaches to treatment must eradicate LSCs for cure.

157 In contrast, ven/aza fails to eradicate LSCs in relapsed/refractory (R/R) patients, su

158 ukemic stem cells (LSCs), it is essential to eradicate LSCs to improve patient survival.

159 ch has promising implications for efforts to eradicate malaria.

160 ey intervention target of ongoing efforts to eradicate malaria.

161 existing vector control strategies is key to eradicating malaria in the near future.

162 he leverage of this knowledge to effectively eradicate malignant cells, has revolutionised the field

163 tem cells (CSCs) is necessary to permanently eradicate malignant tissues.

164 mAbs have potential as novel therapeutics to eradicate MDS HSCs and augment the curative effect of al

165 of PIP3-specific Myo1D and Myo1F completely eradicates membrane binding.

166 hropocene extinctions suggest a strategy for eradicating metastatic cancers in which initial therapy,

167 To develop a new treatment of eradicating metastatic PCa, we have created an injectabl

168 ble-edged swords in sepsis; they can help to eradicate microbes, but they also contribute to tissue i

169 ng chemical and physical contaminants and on eradicating microbes; however, there is a growing awaren

170 riminate self from non-self is essential for eradicating microbial pathogens but is also responsible

171 d shown that such treatments are unlikely to eradicate microtumors.

172 However, single-agent venetoclcax fails to eradicate minimal residual disease in most patients.

173 d synergized with the BH3-mimetic ABT-199 in eradicating MLL-rearranged B-ALL cells.

174 two treatments for synergistic effects could eradicate more tumor cells and increase the overall surv

175 yeloid leukemia, we showed that leukemia was eradicated more effectively in DGKzeta-deficient (DGKzet

176 gical inhibition of c-FOS, DUSP1 and BCR-ABL eradicated MRD in multiple in vivo models, as well as in

177 Remarkably, topical auranofin completely eradicated MRSA (8-log(10) reduction) in infected PUs of

178 no available therapy capable of selectively eradicating myofibroblasts or limiting their genesis.

179 Gentamicin alone failed to eradicate N. gonorrhoeae from the pharynx.

180 Gentamicin alone failed to eradicate Neisseria gonorrhoeae from the pharynx.

181 We also discuss the importance of eradicating NPM1-mutated clones to achieve AML cure and

182 bunit expression and proteolytic activity to eradicate nuclear FOXO4 proteins from RAS-mutant cancer

183 ry high (>90%) coverage has the potential to eradicate oncogenic HPVs, but such high coverage is hard

184 on as a whole - an environmental stress that eradicates one subpopulation may leave other phenotypic

185 d burden of chronic infection, approaches to eradicate or cure HIV infection are desired.

186 chronic HBV infection is their inability to eradicate or inactivate cccDNA.

187 failure of HBV treatment is the inability to eradicate or inactivate the viral covalently closed circ

188 Maternal antibiotic exposure that eradicated or enriched transmission of Lactobacillus mur

189 provides insights into how the immune system eradicates or controls pathogens, while avoiding host da

190 Vaccines have played an important role in eradicating or mitigating the spread of infectious disea

191 Despite global efforts to eradicate orthomyxoviral pathogens, these infections rem

192 ll lung cancer (NSCLC) xenografts and nearly eradicated orthotopically implanted NSCLC xenografts.

193 D28-transduced leukemia-specific CD8 T cells eradicated otherwise lethal disease more efficiently tha

194 aling pathway inhibitor has the potential to eradicate ovarian cancer stem cells and to prevent ovari

195 he pre-clinical and clinical significance of eradicating pancreatic cancer stem cells (PCSC) and its

196 To eradicate pandemics, present and future, a successful va

197 uently, strategies to control, eliminate and eradicate parasites represent the most feasible way to r

198 Human CD83 CAR T cells eradicate pathogenic CD83+ target cells, substantially i

199 neutrophils invade sites of inflammation to eradicate pathogens and clear debris.

200 marker of GC in H. pylori-infected but not -eradicated patients.

201 MAbs and ITs to kill HIV-infected cells and eradicate persistent reservoirs of HIV infection.

202 ment with the neuroprotective agent P7C3-A20 eradicates persistent remote fear.

203 cell membrane function have the potential to eradicate "persister" organisms and delay the emergence

204 Efforts to eradicate Plasmodium vivax malaria are hampered by the p

205 Primaquine is the only licensed drug for eradicating Plasmodium vivax hypnozoites and, therefore,

206 F-managed SMNet was created as a strategy to eradicate polio by engaging >7000 frontline social mobil

207 Its unwavering commitment to eradicate polio has been vital to the success of the pro

208 Pakistan faces huge challenges in eradicating polio due to widespread poliovirus transmiss

209 Vaccination has essentially eradicated poliovirus.

210 ther therapies targeting these mutations can eradicate premalignant cells is unclear.

211 ical interventions to prevent progression or eradicate premalignant clones prior to the development o

212 ously, migrated to tumor sites, and robustly eradicated primary tumors.

213 light this receptor as a potential target to eradicate primitive LSCs in AML.

214 minal splice variant of PTEN, were unable to eradicate Pseudomonas aeruginosa from the airways and co

215 ing from 2 to 32 muM, whereas only R1 and R4 eradicated Pseudomonas aeruginosa biofilms at 16 muM.

216 ablation is the most efficacious approach to eradicate PVCs but may confer increased upfront risks.

217 A key to reduce and eradicate racial disparities in hypertension outcomes is

218 the sick individuals above which disease is eradicated rapidly.

219 the addition of antibiotics was required to eradicate remaining planktonic populations.

220 (RT) in breast cancer (BC) is often used to eradicate remaining tumor cells following surgery with t

221 cing chemotherapies are often ineffective at eradicating residual disease, despite efficiently killin

222 mechanism of host cell death that failed to eradicate S. aureus and instead promoted DeltahemB SCV p

223 ds producing 17, 10 and 7 mM HOCl completely eradicated S. aureus, A. baumannii, and P. aeruginosa bi

224 tro studies and was also highly effective in eradicating S. aureus biofilm infection when used in a C

225 n essential mechanism used by macrophages to eradicate Salmonella is production of reactive oxygen sp

226 of fibronectin (F8-TNF), can be exploited to eradicate sarcomas in immunocompetent mice.

227 2 poliovirus the first human pathogen to be eradicated since smallpox.

228 family, was used as a live-virus vaccine to eradicate smallpox worldwide and has recently received c

229 hat gold nanoparticles (AuNPs) with RT could eradicate some brain tumors in mice and many other precl

230 udy; indeed, the promise of the potential to eradicate such cells is clear.

231 Not only have we not eradicated syphilis, rates of infection have increased i

232 and selection against these variants should eradicate TH.

233 val-extinction [R-E] training) can attenuate/eradicate the ability of cues to elicit learned behavior

234 also be a crucial tool in ongoing efforts to eradicate the beetle from regions of the world that it h

235 vinblastine, etc) used for maintenance could eradicate the BRAF(V600E) clone.

236 me coronavirus 2 (SARS-CoV-2) is critical to eradicate the coronavirus disease 2019 (COVID-19) pandem

237 Repurposing of FDA-approved drugs that can eradicate the CSC subcompartment in primary tumors may p

238 However, a longer containment that can eradicate the disease imposes a smaller loss than shorte

239 e behavior by the healthy individuals cannot eradicate the disease without the preemptive measures of

240 research and clinical community aspiring to eradicate the disease.

241 ains staggering despite extensive efforts to eradicate the disease.

242 nd experimental time from 2 days to 4 h, but eradicate the FAW as soon as it enters a new area.

243 targeting this emerging infectious agent can eradicate the infection and prevent the development of n

244 p gastric colonization rates and are able to eradicate the infection in up to 60% of the mice.

245 penetrating keratoplasties were required to eradicate the infection.

246 1 replication and preventing AIDS, it cannot eradicate the infection.

247 ial clearance, thus presenting a strategy to eradicate the infection.

248 l centres to be suitable for intervention to eradicate the lesion, were eligible for inclusion.

249 preclinical approaches that show promise to eradicate the LSC, and future challenges on the path to

250 tor function, the immune system is unable to eradicate the malignant clone.

251 r PI3K pathway inhibition is insufficient to eradicate the most common cytokine receptor-like factor

252 ating that suppressing RUNX activity may not eradicate the most immature LSCs.

253 n is the inability of existing treatments to eradicate the multiple HIV reservoirs in the human body,

254 ay contribute to synovitis after antibiotics eradicate the pathogen.

255 ious cellular defense mechanisms designed to eradicate the viral infection.

256 ovides a promising strategy to reduce if not eradicate the viral reservoir.

257 cass removal is the most effective method to eradicate the virus without also eradicating the host po

258 otently inhibit HIV replication, they do not eradicate the virus.

259 d virus transmission, but treatment does not eradicate the virus.

260 and stamping-out has successfully reduced or eradicated the disease from Europe and large parts of So

261 The higher dose, 11.1 MBq, eradicated the tumor but had no effect on survival compa

262 ontal lineTap at the position of d-Phe1-Pro2 eradicates the biological activity (GS mimetic 16).

263 ws significant antitumor efficacy and nearly eradicates the tumor, substantiating the importance of t

264 ovement programmes aiming at controlling and eradicating the disease.

265 s are elusive for polymer acceptors to date, eradicating the drawbacks inherited in N2200 and other h

266 e method to eradicate the virus without also eradicating the host population, and that early implemen

267 V DNA, which is one of the major barriers to eradicating the virus from PLWH.

268 ver, because wild-type 2 poliovirus has been eradicated, the World Health Organization's (WHO's) Stra

269 However, no subject eradicated their infecting P. aeruginosa strain, and aft

270 therapeutic strategies that could be used to eradicate them.

271 abolic vulnerabilities of LSC to selectively eradicate them.

272 nce, and aided precision medicine efforts to eradicate therapy-resistant cancer cell clones.

273 rug-tolerant represents an essential step to eradicate these persisting subpopulations.

274 Current efforts to eradicate these tumors focus predominantly on targeting

275 If gene drives successfully eradicated these invasive populations, many would rejoic

276 HIV reservoir, and alternative strategies to eradicate this reservoir must be sought.IMPORTANCE Effor

277 Complementary regional efforts eradicated this pest throughout the cotton-growing areas

278 Importantly, virtual lesion of pSTS eradicated this suppressive mechanism and restored objec

279 to-apply nanomedicine may find broad use for eradicating toxic amyloid proteins implicated in a range

280 antibody-dependent cellular cytotoxicity to eradicate tumor cells via recruitment and activation of

281 unological systems to recognize, attack, and eradicate tumor cells with minimal damage to healthy cel

282 Although chemotherapy is designed to eradicate tumor cells, it also has significant effects o

283 n loss of ERalpha-driven gene expression and eradicated tumor cell proliferation.

284 lesions at the end of therapy may constitute eradicated tumor/scar tissue.

285 Eradicating tumor dormancy that develops following epide

286 ls can migrate from biopolymer scaffolds and eradicate tumors more effectively than does systemic del

287 is to re-ignite T-cell immunity, in order to eradicate tumors.

288 their ability to clear chronic infections or eradicate tumors.

289 ose absence enables powerful CD8+ T cells to eradicate tumors.

290 n of these cytokines synergized with MEKi in eradicating tumors.

291 eing made to develop new strategies that can eradicate tumours selectively without detrimental effect

292 with the antibiotic ciprofloxacin completely eradicates UPEC from the urinary tract and prevents the

293 , and disseminated cancer populations can be eradicated using similar evolutionary dynamics.

294 In North and Central America it was eradicated using the Sterile Insect Technique (SIT).

295 etroviral therapy was proposed as a means to eradicate viral reservoirs.

296 and HBV, suppress HBV DNA levels but do not eradicate virus because the transcriptional template, co

297 Failure of the immune system to eradicate viruses results in chronic viral infections, w

298 rates in obese versus lean individuals were eradicated when normalised to whole-body fat mass (P = 0

299 Eradicating world hunger-the aim of Sustainable Developm

300 mize Minyoo Kenya Imarisha Afya (Swahili for Eradicate Worms in Kenya for Better Health [TUMIKIA]) tr