ライフサイエンスコーパス: error-prone

1 ting that the process of nuclear division is error prone.

2 onal mechanisms underlying CNV formation are error prone.

3 multiple environments are time consuming and error prone.

4 logeny, ancestral sequence reconstruction is error prone.

5 ne them by hand, which is time-consuming and error-prone.

6 ining why early embryonic cell cycles are so error-prone.

7 process is subjective, nonquantitative, and error-prone.

8 obtain inverse probability weights are often error-prone.

9 ing individual atoms remains challenging and error-prone.

10 containing A and U, is particularly slow and error-prone.

11 experience, despite the fact that gossip is error-prone.

12 anually, which is time-consuming and usually error-prone.

13 oteasome-mediated repair of TOP2cc is highly error-prone.

14 measurements of resistance is laborious and error-prone.

15 Furthermore, end resection promotes error-prone A-EJ.

16 ts as a backup attempt to intercept the more error-prone alternative NHEJ repair pathway by recruitin

17 An error-prone, alternative form of end joining, operating

18 n 1 (XRCC1), all essential components of the error-prone, alternative nonhomologous end-joining (alt-

19 esion DNA polymerases that are intrinsically error prone and associated with mutagenesis, drug resist

20 d for this correction are time consuming and error prone and existing programs are often platform spe

21 ng sample records and pedigrees can often be error prone and incomplete.

22 owever, manual assembly planning is complex, error prone and not scalable.

23 ocess of the ASFV virus genome; it is highly error prone and plays an important role during the strat

24 ly constructing DC libraries is challenging, error prone and time consuming.

25 This approach is time consuming, error prone and unsuitable for combining datasets from m

26 ithout relying on generic assembly, which is error-prone and computationally expensive for complex da

27 cted via NGS, the reads generated by NGS are error-prone and even a single nucleotide error precludes

28 e of the synthetic site, bringing about less error-prone and kinetically optimized isoleucyl-tRNA(Ile

29 entry receptors, followed by a discussion on error-prone and low-fidelity polymerases and their impac

30 decision-making requires balancing fast but error-prone and more accurate but slower decisions throu

31 plants and animals have polymerases that are error-prone and produce complex populations of related,

32 because cell division in polyploid cells is error-prone and produces aneuploid cells.

33 previously described plasmids using ad hoc, error-prone and time-consuming curation processes becaus

34 However, the techniques are error prone, and the methods commonly used to control fo

35 Meiosis in human oocytes is highly error-prone, and defective eggs are the leading cause of

36 trum-peptide pairs, which is time-consuming, error-prone, and difficult to apply.

37 However, this process is quite error-prone, and initial errors are corrected during a s

38 I find that RNA polymerase is error-prone, and these errors can result in splicing def

39 Lig4(R278H) activity renders NHEJ to be more error-prone, and they predict increased error-prone NHEJ

40 studies either reduce available data or are error-prone, and thus, scalable methods that do not disc

41 f prototyping device designs can be tedious, error-prone, and time-consuming.

42 tep data processing is complicated, operator error-prone, and time-consuming.

43 monstrate that bypass of LdG modification is error prone as well as slow compared to that across the

44 ly using a DNA sequence editor which becomes error-prone as scale and complexity of the construction

45 Though they have 65% identity, WHV Cp has error-prone assembly with stronger protein-protein assoc

46 bly, even though Pols eta and iota are quite error-prone at inserting nucleotides opposite 1-MeA, TLS

47 cient NHEJ, but also its contribution to the error-prone behavior of Polmu at 2-nt gaps.

48 current superresolution measurements become error-prone below 25 nm.

49 wing TH588 treatment in cells expressing the error-prone but not wild-type Pol delta variant, which i

50 DNA synthesis by purified Poldelta-R696W was error-prone, but not to the extent that could account fo

51 polymerases and often requires the action of error prone bypass polymerases.

52 Thus, WRN limits the error-prone bypass of 8-oxo-dG by hpol kappa, which coul

53 ations; Pol eta and Pol zeta participated in error-prone bypass of the straight-chain lesions, wherea

54 ized lesions: 8OG allows both error-free and error-prone bypass, whereas Gh or Sp causes strong stall

55 tically ill patients require time-consuming, error-prone calculations using static variable threshold

56 The basis for particularly error-prone chromosome segregation in human oocytes is n

57 ngency of checkpoint signaling, resulting in error-prone chromosome segregation.

58 ined uncoupled from APC activity, leading to error-prone chromosome segregation.

59 han 100 live human oocytes and identified an error-prone chromosome-mediated spindle assembly mechani

60 acturing methods still rely on a multi-step, error-prone complex process that requires a costly clean

61 We substantiated this by showing that under error-prone conditions S. griseus IleRS is able to rescu

62 dy, we examined the consequences of multiple error-prone covariates when estimating causal effects us

63 Here, we show that error-prone damage bypass on the lagging strand plays a

64 However, because of the incomplete and error-prone datasets currently available, such methods h

65 consequence, haplotyping methods suffer from error-prone discrete SNP genotypes (AA, AB, BB) and DNA

66 Given the error-prone disposition of PrimPol, we propose a mechani

67 hese genes also stimulated HDR, and promoted error-prone distal end-joining.

68 By promoting error-prone DNA damage repair via NHEJ and suppressing a

69 Our findings implicate low-fidelity, error-prone DNA polymerase activity in synthesis associa

70 We link error-prone DNA polymerase activity to the generation of

71 ervative template modifications give rise to error-prone DNA polymerase activity.

72 in Ab genes, indicating that DNA repair and error-prone DNA polymerase eta usage were unaffected.

73 We found that recA and all of the multiple error-prone DNA polymerase V (Pol V) genes, those organi

74 cover from treatment, and the involvement of error-prone DNA polymerase V (UmuDC).

75 plisome defects promote the participation of error-prone DNA polymerase zeta (Polzeta) in replication

76 Escherichia coli SOS DNA-damage response and error-prone DNA polymerases in all cells.

77 Our analysis suggests the contribution of error-prone DNA polymerases to the latter signatures.

78 exposure also results in the recruitment of error-prone DNA polymerases to the replication fork.

79 enes, especially those encoding the multiple error-prone DNA polymerases, can be implicated in induce

80 tic hypermutation (SHM) targeting, including error-prone DNA repair activities that are crucial to Ab

81 aintains UmuD, an important component of the error-prone DNA repair polymerase (Pol V), at very low l

82 solvent-exposed conformation, which enables error-prone DNA replication past the adduct.

83 into HIV-1 containing D67N/K70R reversed the error-prone DNA synthesis at codons 65-67 in RT and impr

84 DNA sequences and point mutations caused by error-prone DNA synthesis at DNA structures.

85 However, error-prone DNA synthesis by PrimPol using the G4 templa

86 olymerase stalling at DNA structures induces error-prone DNA synthesis, which constrains STR expansio

87 NA strand to mutagens and primes unscheduled error-prone DNA synthesis.

88 In turn, BRCA-deficient cells utilize error-prone DNA-repair pathways, causing increased genom

89 , this work elucidates a strategy for using "error-prone" DNA-repair machinery to generate precise ed

90 on, potentially induced by a higher level of error-prone double-strand break repair in these regions,

91 ology, a signature associated with a backup, error-prone double-strand break repair pathway known as

92 tive in RecA-mediated strand exchange during error-prone double-strand break repair.

93 rase that mediates a microhomology-mediated, error-prone, double strand break (DSB) repair pathway, r

94 hese TLS polymerases play a critical role in error-prone DpC bypass.

95 models of its DNA binding specificity remain error prone due to a lack of understanding of how adjace

96 that the spliceosome "toggles" between such error-prone/efficient and hyperaccurate/inefficient conf

97 Furthermore, we show that error-prone/efficient RH alleles suppress a prp2 mutant

98 with the two structures: those that promote error-prone/efficient splicing and those that promote hy

99 lapsed forks are preferentially repaired via error-prone end joining as depletion of EXO1 diverts rep

100 could effectively restore Fancf function via error-prone end joining resulting in a 27% increased sur

101 Electron microscopy imaging shows that the error-prone Escherichia coli strain lacks mature flagell

102 Protein folding is inherently error prone, especially in the endoplasmic reticulum (ER

103 identifies specific homopolymer sequences in error-prone EST/cDNA data or RNA-Seq data at a speed app

104 , where spindle bipolarization is reportedly error prone, exhibit no detectable kinetochore enrichmen

105 ove lesions or bypass them in a more or less error-prone fashion.

106 which target to pursue is a challenging and error-prone first step in developing a therapeutic treat

107 analysis and avoid the complexities of using error prone flat-files.

108 In addition to an error-prone genome replication mechanism, RVs can increa

109 Viruses rapidly evolve due to their error-prone genome replication, and identifying which mu

110 With error prone high throughput NGS reads and genomic repeat

111 is fueled, in part, by the presumably highly error-prone HIV polymerase reverse transcriptase (RT).

112 ecombination (SCR), generating error-free or error-prone homologous recombination (HR) outcomes.

113 cal gate-keeping step is required to prevent error-prone immature ribosomes from engaging in protein

114 Transforming error-prone immunosequencing datasets into Ab repertoire

115 zed, two-step cell division, which is highly error prone in humans.

116 We show that HR is error-prone in this context because of DNA damage checkp

117 istractor images during more stable and less error prone "in the zone" epochs compared with suboptima

118 the SAC is weak, and chromosome segregation error-prone, in mammalian oocytes.

119 causes strong stalling and only allows slow error-prone incorporation of purines.

120 d AP residue in HEK293T cells was moderately error-prone, inducing a total of approximately 26% singl

121 mologous DNA appears to divert cells towards error-prone instead of error-free repair pathways, drama

122 nclude only 15-40 pesticides, which leads to error-prone interpretations.

123 rse transcriptase is considered to be highly error prone, leading to a high intra-individual evolutio

124 s (TLS), this comes at a cost of potentially error-prone lesion bypass.

125 by fluorescence-activated cell sorting of an error-prone library based on fine discrimination between

126 ASFV DNA ligase (AsfvLIG) is one of the most error-prone ligases identified to date; it catalyzes DNA

127 andful of error correction methods for these error-prone long reads have been developed to date.

128 TS is mainly error-free, TLS can work in an error-prone manner and, as such, the regulation of these

129 T4 DNA polymerase replicating 8-oxo-G in an error-prone manner, they display remarkably low efficien

130 ereas in the other, poltheta functions in an error-prone manner.

131 It can replace expensive and error-prone manual parsing and standardization of scient

132 of this cache of data for Galaxy has been an error-prone manual process lacking reproducibility and p

133 and that elevated soluble EZH2 is part of an error-prone mechanism by which modifying enzyme meets te

134 nd shifting DNA repair from high fidelity to error-prone mechanisms.

135 could complement or even replace the current error-prone method of self-reporting of smoking status a

136 th mutations to a protein called SPOP use an error-prone method to repair broken DNA strands.

137 10 genes) in Escherichia coli using a highly error-prone microchip-synthesized oligo pool (479 oligos

138 DNA double-strand breaks, referred to as the error-prone microhomology-mediated end-joining (MMEJ) pa

139 G-->T transversion, possibly associated with error-prone mismatch repair.

140 effect results from chromosome damage during error-prone mitoses.

141 fzr/Cdh1 overexpression also resulted in an error-prone mitosis with amplified centrosomes and high

142 onhomologous end-joining (NHEJ) and promotes error-prone MMEJ, providing a mechanistic rationale for

143 city, chromosome structural aberrations, and error-prone mutagenic DNA repair following exposure to I

144 ivator RpoS, were upregulated by a ribosomal error-prone mutation.

145 Making error-prone mutator versions of gamma DNA polymerases re

146 cess DNA-based data storage system that uses error-prone nanopore sequencers, while still producing e

147 g antimicrobial resistance determinants from error-prone Nanopore sequencing is a substantial bioinfo

148 We describe an approach that exploits the error-prone nature of genome editing-induced double-stra

149 tion in mice, and provides insights into the error-prone nature of human oocytes.

150 We propose that the error-prone nature of restarted forks contributes to the

151 The error-prone nature of RNA-dependent RNA polymerases driv

152 luding poliovirus, evolve rapidly due to the error-prone nature of the polymerase enzymes involved in

153 The error-prone nature of TLS may provide mechanistic unders

154 Additionally, due to the error-prone nature of viral RNA synthesis in an individu

155 However, high-throughput sequencing remains error-prone, necessitating variant confirmation in order

156 ng-strand genes, activating an Mfd-dependent error-prone NER mechanism.

157 more error-prone, and they predict increased error-prone NHEJ activity and A-EJ suppression as the ca

158 correction/insertion, significantly reducing error-prone NHEJ events at the nuclease cleavage site, w

159 mbination (HR) while stymieing repair by the error-prone non-homologous end joining (NHEJ) pathway.

160 ntroduce mutation (insertion or deletion) by error-prone non-homologous end joining DNA repairing.

161 combination repair (HR), while counteracting error-prone non-homologous end joining of DNA double-str

162 locus, followed by repair through either the error-prone non-homologous end joining or the homology d

163 ent repair (HDR) is limited by the competing error-prone non-homologous end-joining (NHEJ) DNA repair

164 discriminate between high-fidelity (HF) and error-prone non-homologous end-joining (NHEJ), as well a

165 ly generate knockout cells and organisms via error-prone nonhomologous end joining (NHEJ), but the ef

166 d consequently triggers an activation of the error-prone nonhomologous end joining response.

167 been recently demonstrated that HSCs use the error-prone nonhomologous end-joining (NHEJ) pathway of

168 A damage likely because they mainly used the error-prone nonhomologous end-joining pathway to repair

169 ERG gene breakpoint of proteins that promote error-prone nonhomologous end-joining.

170 on-based targeting maps are distorted by the error-prone or error-free repair of these uracils and by

171 The error prone organelle DNA polymerase introduced mutation

172 ce to the wild type enzyme in vitro make the error prone organelle DNA polymerase suitable for elevat

173 Visual delineation of tumor margins is error-prone owing to the limited contrast between cancer

174 These polymerases are inherently error prone, owing to their lack of a proofreading (3'-

175 his problem, benchmark it on the set of long error-prone Oxford Nanopore reads generated by the Telom

176 virulence plasmid, pPCP1, MinION reads were error-prone, particularly in homopolymer regions.

177 rprinting is one of the most challenging and error-prone parts of the analytical procedure.

178 icrohomology-mediated end joining (MMEJ), an error-prone pathway for DNA double-strand break (DSB) re

179 y the replisome without the need to activate error-prone pathways.

180 nduct TLS opposite epsilondA via alternative error-prone pathways.

181 Escherichia coli lsr operon promoters using error-prone PCR (ePCR) and selected for promoters that p

182 l. apply a screening approach that leverages error-prone PCR and a proliferating cell model to identi

183 A single round of error-prone PCR and selection yielded variant ALR(Y274F)

184 Error-prone PCR mutagenesis reinforced the importance of

185 h this inhibitor, we randomly mutagenized by error-prone PCR the E. coli dsbB gene and selected dsbB

186 tution at amino acid 42 was discovered using error-prone PCR to generate additional mutations.

187 When mutations are enhanced through error-prone PCR, in vitro M2-seq experimentally resolves

188 yield higher-performing variants faster than error-prone PCR-derived libraries.

189 te familiar face recognition but also to our error-prone performance with unfamiliar faces.

190 The error-prone Pol zeta can also participate in replication

191 show that broken fork repair initially uses error-prone Pol32-dependent synthesis, but that mutageni

192 deleterious and, fueled by the drug-induced error-prone polymerase Pol IV, overwhelms cells with tox

193 iously shown to dominate the spectrum of the error-prone polymerase Pol zeta, suggesting that low-fid

194 fected tandem mutations generated by another error-prone polymerase, Pol zeta.

195 zaki fragment processing, DNA synthesized by error-prone polymerase-alpha (Pol-alpha) is retained in

196 /Pol30 polymerase clamp or deleting specific error-prone polymerases abolishes the mutagenic effect o

197 es a simple explanation for the existence of error-prone polymerases and yields a formal counter-argu

198 -repair genes and concomitantly up-regulates error-prone polymerases in drug-tolerant (persister) cel

199 disturbances that trigger the recruitment of error-prone polymerases in the absence of DNA damage and

200 Error-prone polymerases overcome this blockade by synthe

201 spiral is fueled by specialized proteins and error-prone polymerases that change DNA sequences.

202 d by exogenous agents, and the activities of error-prone polymerases.

203 nal replication forks lead to recruitment of error-prone polymerases.

204 to shield the AP site from endonucleases and error-prone polymerases.

205 lassical NHEJ (c-NHEJ) and a poorly defined, error-prone process termed alternative NHEJ (a-NHEJ).

206 ce in the absence of centrosomes, this is an error-prone process that opens up the fly to development

207 ny dataset manipulation a time-consuming and error-prone process.

208 patient and the care of outlier patients as error-prone processes.

209 erated through a novel mechanism mediated by error-prone processing of AP sites accumulated in the st

210 rotein crosslink to shield abasic sites from error-prone processing.

211 etween two variables when the predictors are error-prone proxies (EPPs).

212 gamma-HOPdG was accomplished only following error-prone purine nucleotide incorporation.

213 ntial for reproduction, is also variable and error-prone: rates of chromosome crossover vary among ga

214 eralize de Bruijn graphs for assembling long error-prone reads and describe the ABruijn assembler, wh

215 yet approaches for leveraging their long but error-prone reads for genotyping are lacking.

216 res) faced the challenge of translating long error-prone reads from the nucleotide alphabet into the

217 Moreover, since the mapping of error-prone reads to ETRs remains an open problem, it is

218 novo genome assemblies, but fully exploiting error-prone reads to resolve repeats remains a challenge

219 The recent breakthroughs in assembling long error-prone reads were based on the overlap-layout-conse

220 algorithm for centromere assembly using long error-prone reads, and apply it to assemble human centro

221 , we study the overlap detection problem for error-prone reads, which is the first and most critical

222 only practical paradigm for assembling long error-prone reads.

223 and can only be assembled manually from long error-prone reads.

224 of stalled forks to NPCs and restriction of error-prone recombination between repeated sequences.

225 sed proliferation, premature senescence, and error-prone recovery from serum deprivation after immort

226 rand cross-link repair, leading to increased error-prone repair and genome instability.

227 either endonuclease activity and subsequent error-prone repair have left a mutational footprint on t

228 This error-prone repair pathway is triggered upon telomere de

229 across the genome and detected signatures of error-prone repair pathways at the breakpoints.

230 cytidine deaminase are processed by multiple error-prone repair pathways.

231 Whereas SHM involves an error-prone repair process that introduces novel point m

232 d cytidine deaminase-induced DNA lesions and error-prone repair that underlie SHM are known to exhibi

233 owever, nonhomologous end-joining (NHEJ), an error-prone repair, acts concurrently, reducing the rate

234 Because apurinic sites are subject to error-prone repair, leading to substitution and short fr

235 ated lesions are processed by error-free and error-prone repair.

236 uits low fidelity DNA polymerases to promote error-prone replication across DNA lesions.

237 gh potential for population diversity due to error-prone replication and short generation times.

238 ence variability of the virus resulting from error-prone replication has thwarted the discovery of a

239 lays a key role in translesion synthesis, an error-prone replication mechanism.

240 that carries out translesion synthesis, the error-prone replication of damaged DNA.

241 currence of RNF43-G659Vfs*41 may result from error-prone replication of the 7-G repeat in MLH1-defici

242 ive RNA replicons: (a) small size imposed by error-prone replication, (b) high G + C content to incre

243 icient than that in smaller RNA viruses with error-prone replication, as seen via signatures of selec

244 ts metagenomic environment.IMPORTANCE Due to error-prone replication, HIV-1 generates a diverse popul

245 ng that the 8-oxo moiety greatly facilitated error-prone replication.

246 t of the Fanconi anaemia pathway, inhibiting error-prone replicative lesion bypass and interstrand cr

247 ically uridylylated and that this priming is error prone, resulting in the loss of sequence informati

248 vealed that post-lesion synthesis was highly error-prone, resulting in mutations opposite the adducte

249 bonucleotides are removed by NER followed by error-prone resynthesis with DnaE.

250 ems are remarkable genetic elements that use error-prone reverse transcriptases to generate vast sequ

251 served in M. florum, which apparently has an error-prone RNA polymerase.

252 fluenza A viruses (IAV) acquired through the error-prone RNA-dependent RNA polymerase (RdRP) or throu

253 hniques, they often can produce only partial error-prone scaffold assemblies.

254 que from Oxford Nanopore, can generate long, error-prone sequencing reads which pose new challenges f

255 -up role in the repair of DSBs performing an error-prone single strand annealing (SSA).

256 tion and remains the most time-consuming and error-prone step.

257 ts transcription, and deleting DsrA from the error-prone strain restores motility.

258 trate that an increased level of DsrA in the error-prone strain suppresses motility through the H-NS

259 RpoS contribute to peroxide tolerance in the error-prone strain, and a small RNA DsrA, which controls

260 polyploid papillar divisions are frequently error prone, suggesting papillar structures may accumula

261 2 position of guanine significantly increase error-prone synthesis catalyzed by pol eta when replicat

262 ted into the single-strand nick required for error-prone synthesis is an open question.

263 approximately 4, helps rationalize the more error-prone synthesis opposite the lesion by hpol eta.

264 odel specification, avoiding the tedious and error prone task of manually enumerating all species and

265 ar simulation engine remains a difficult and error-prone task.

266 This strategy should reduce the number of error-prone, tedious and time-consuming weighing procedu

267 agreement by showing that HIV RT is not more error prone than other RTs and, when assayed under physi

268 l II elongation complexes, and Pol I is more error prone than Pol II.

269 suggest that, although object naming is more error prone than reading, subjects can afford to rely mo

270 methods produce lower coverage, and are more error prone than short-read sequencing, these methods co

271 Pol IV transcription is considerably more error-prone than Pols II or V, which may be tolerable in

272 larativity, making it more flexible and less error-prone than traditional approaches.

273 But since qubits are noisy and error-prone, they will depend on fault-tolerant quantum

274 The error-prone third-generation sequencing (TGS) long reads

275 Poleta(-/-) mice support the conclusion that error-prone TLS by Poltheta provides a safeguard against

276 ontributions of error-free TLS by Poleta and error-prone TLS by Poltheta to the replication of UV-dam

277 cooperatively carry out the majority of the error-prone TLS of dG-C8-IQ, whereas pol eta is involved

278 Strikingly, in contrast to extremely error-prone TLS opposite epsilondA by purified Poltheta,

279 sis (TLS) allows bypass of DNA lesions using error-prone TLS polymerases.

280 correction, beyond which long reads are too error-prone to be corrected by these methods.

281 We tested the fidelities of error prone tobacco organelle DNA polymerases using a no

282 ching in the lac operon (with and without an error-prone transcription slippage sequence), partial ph

283 s that are genetically engineered to display error-prone transcription.

284 reventing untimely tRNA and mRNA binding and error prone translation.

285 the primary repair/tolerance mechanism over error-prone translesion DNA polymerases.

286 ures associated with DNA polymerase zeta, an error-prone translesion polymerase, and the APOBEC famil

287 nner via Brca2 instead of being processed by error-prone translesion polymerases.

288 Error-prone translesion synthesis causes the majority of

289 Unexpectedly, replicative pol delta and the error-prone translesion synthesis pol zeta were able to

290 ccurate genome-replicating category or is an error-prone translesion synthesis polymerase.

291 omes can directly replicate past a lesion by error-prone translesion synthesis.

292 equence contexts that may have arisen due to error-prone translesional synthesis.

293 of waking life and is often associated with error-prone, variable behavior.

294 s, DNA polymerase delta (Pol delta), with an error-prone variant allows increased 8-oxodG accumulatio

295 ile efficient, can be disadvantageous due to error-prone viral polymerases.

296 labeling variants as causal or benign can be error prone, which is problematic for training supervise

297 owever, both NGS data and their analysis are error-prone, which can lead to the generation of false p

298 Current sequencing methods are error-prone, which precludes the identification of low f

299 ll studied archaeal homologues of pol IV, an error prone Y-family polymerase from Escherichia coli.

300 A polymerases but are presumably bypassed by error-prone Y-family DNA polymerases at the expense of r