ライフサイエンスコーパス: erythroid progenitor

1 d from a common precursor, the megakaryocyte-erythroid progenitor.

2 e expression downstream of the megakaryocyte-erythroid progenitor.

3 yocytes after formation of the megakaryocyte-erythroid progenitor.

4 1 to inhibit commitment to the megakaryocyte-erythroid progenitor.

5 2, is expressed preferentially and highly on erythroid progenitors.

6 also causes Epo hypersensitivity in primary erythroid progenitors.

7 es, we profiled the transcriptome of primary erythroid progenitors.

8 complex and is required for the survival of erythroid progenitors.

9 ajor new EPO/EPOR target for the survival of erythroid progenitors.

10 e clonal expansion of Kit(+) multipotent and erythroid progenitors.

11 ses >100 PU.1 myelo-lymphoid gene targets in erythroid progenitors.

12 vivo differentiation of Hri(-/-) fetal liver erythroid progenitors.

13 mming and subsequent generation of committed erythroid progenitors.

14 and active histone marks similar to those in erythroid progenitors.

15 is by stimulating the expansion of primitive erythroid progenitors.

16 he (pA)d site during B19V infection of human erythroid progenitors.

17 humans and has an extreme tropism for human erythroid progenitors.

18 ar pathogenesis of B19V in highly permissive erythroid progenitors.

19 apid expansion and differentiation of stress erythroid progenitors.

20 markable tropism of B19V infection for human erythroid progenitors.

21 ng gamma-globin transcription in adult human erythroid progenitors.

22 iking decrease in multipotential myeloid and erythroid progenitors.

23 the fetal liver contains two populations of erythroid progenitors.

24 ex vivo proliferation and immortalization of erythroid progenitors.

25 oblast, primitive, erythroid, and definitive erythroid progenitors.

26 , and cytokine-independent growth of primary erythroid progenitors.

27 vity, and P4.2 and beta-globin expression in erythroid progenitors.

28 induced erythropoietin receptor signaling in erythroid progenitors.

29 c, and granulocytic cells as well as primary erythroid progenitors.

30 ding Stat5, Akt, and p44/42 MAPK, in primary erythroid progenitors.

31 oid gene such as GATA-2 in the megakaryocyte-erythroid progenitors.

32 ansion of a specialized population of stress erythroid progenitors.

33 , suggesting that IL-7 might directly act on erythroid progenitors.

34 ncostatin-M was found to enhance survival of erythroid progenitors.

35 in the yolk sac with Meg-CFCs and definitive erythroid progenitors.

36 onferred a proliferative signal to primitive erythroid progenitors.

37 creased, with only modest expansion of early erythroid progenitors.

38 in developmental stage-discordant definitive erythroid progenitors.

39 a-globin gene promoter and in cultured human erythroid progenitors.

40 ed Epo-induced signaling pathways in splenic erythroid progenitors.

41 proteins in dexamethasone-treated PB and CB erythroid progenitors.

42 opoietic stem/progenitor cells and committed erythroid progenitors.

43 poR in UT7 erythroid cells and primary CD71+ erythroid progenitors.

44 apitulates the in vivo development of stress erythroid progenitors.

45 -3 KO mice, as evidenced by higher levels of erythroid progenitors.

46 myeloid colony formation by Rcor1-deficient erythroid progenitors.

47 monocytic) and erythroid (burst-forming unit-erythroid) progenitors.

48 tained in human umbilical cord blood-derived erythroid progenitor-2 cells, in which beta-globin expre

49 of Meis1 repressed the development of early erythroid progenitors, acting in vivo at the megakaryocy

50 and betae1-globin, suggesting that both the erythroid progenitor and mature erythrocyte compartments

51 ify a unique glucocorticoid-responsive human erythroid progenitor and provide new insights into gluco

52 e from a common precursor, the megakaryocyte-erythroid progenitor and share many regulators including

53 matopoietic stem cells resulted in a loss of erythroid progenitors and an increase in myeloid cells b

54 ne system, Zbtb46 was expressed in committed erythroid progenitors and endothelial cell populations.

55 osis is driven by increased numbers of early erythroid progenitors and enhanced erythroblast prolifer

56 ilia and thrombocytosis, marked expansion of erythroid progenitors and Epo-independent erythroid colo

57 We found increased numbers of erythroid progenitors and erythroid cells in C/EBPalpha(

58 ranscription of the cdk6 gene in both normal erythroid progenitors and erythroleukemia cells, as well

59 displayed an increase in colony-forming unit-erythroid progenitors and in all erythroblast population

60 sion of immature and lineage-committed myelo-erythroid progenitors and ineffective erythropoiesis.

61 9-deficient embryos, deltaNp63 is induced in erythroid progenitors and may contribute to blood defect

62 in Vhl(R/R) spleens, with greater numbers of erythroid progenitors and megakaryocytes and increased e

63 Erythroid progenitors and precursors were increased in h

64 oid differentiation of murine megakaryocytic/erythroid progenitors and primary human CD34(+) progenit

65 in marrow and with emergence of circulating erythroid progenitors and subsequent reestablishment of

66 transcriptional activity and accumulation of erythroid progenitors and that it may do so in an AhR-de

67 it-mediated proliferative expansion of early erythroid progenitors and, ultimately, transient reticul

68 AK is thought to be expressed in myeloid and erythroid progenitors, and its expression is enhanced in

69 ation, a mild anemia with reduced numbers of erythroid progenitors, and significant inhibition of ter

70 ority of microRNAs (miRNAs) present in CFU-E erythroid progenitors are down-regulated during terminal

71 r instances of HIFs upregulation, VHL(P138L) erythroid progenitors are hypersensitive to erythropoiet

72 topoietic stem cells (HSC) and megakaryocyte-erythroid progenitors are markedly increased, whereas gr

73 se results demonstrate that V617F-homozygous erythroid progenitors are present in most patients with

74 beta-globin mRNA within the nucleus of early erythroid progenitors are unlikely to account for the co

75 ocyte-monocyte progenitor, and megakaryocyte-erythroid progenitor), as well as the lymphoid-primed mu

76 ence on the fate choice at the megakaryocyte-erythroid progenitor between megakaryocytic and erythroi

77 Burst-forming unit erythroid progenitors (BFU-Es) are so named based on the

78 cifically stimulate self-renewal of an early erythroid progenitor, burst-forming unit erythroid (BFU-

79 (Epo) supports the development of committed erythroid progenitors, but its ability to act on upstrea

80 rolling proliferation and differentiation of erythroid progenitors, but regulatory mechanisms are lar

81 n of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as eryth

82 ed expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other facto

83 ion factor (TF) that plays critical roles in erythroid progenitors by promoting proliferation and blo

84 t form based on hyperplastic bone marrow and erythroid progenitor cell culture; these cases may subse

85 trate that the 11 kDa protein contributes to erythroid progenitor cell death during B19V infection.

86 ere, we report the establishment of a murine erythroid progenitor cell line, iEBHX1S-4, developmental

87 Erythroid progenitor cell lines have been derived from c

88 eveloped an ex vivo-generated TP composed of erythroid progenitor cells (EPCs) and precursors cells.

89 dvances in generating large numbers of human erythroid progenitor cells (EPCs) ex vivo from hematopoi

90 l role of erythropoietin (Epo) signaling, in erythroid progenitor cells (EPCs) expanded ex vivo from

91 19V) infection has a unique tropism to human erythroid progenitor cells (EPCs) in human bone marrow a

92 2 kinase complexes propagates signals within erythroid progenitor cells (EPCs) that are essential for

93 ythrotropic and preferentially replicates in erythroid progenitor cells (EPCs).

94 eplication, however, is almost restricted to erythroid progenitor cells (ErPCs).

95 red for B19V replication in ex vivo-expanded erythroid progenitor cells after initial virus entry and

96 onomous B19V replication is limited to human erythroid progenitor cells and in a small number of eryt

97 B19 has a strong tropism to erythroid progenitor cells and is able to cause a series

98 Splenic erythroid progenitor cells and mesenchymal stromal cells

99 eq to study the interactome of EKLF in mouse erythroid progenitor cells and more differentiated eryth

100 In accord with this, erythroid progenitor cells and reticulocytes were substa

101 DYRK3 is restricted to erythroid progenitor cells and testes.

102 Infection of erythroid progenitor cells by Friend spleen focus-formin

103 estoration of the cytosol oxidative state of erythroid progenitor cells by the pro-oxidant Paraquat r

104 potential of the vector was demonstrated in erythroid progenitor cells derived from beta(IVS2-654)-t

105 ed, and B19V replication in ex vivo-expanded erythroid progenitor cells exposed to Epo (CD36(+)/Epo(+

106 and excessive erythrocytosis is suggested by erythroid progenitor cells from a patient that exhibits

107 group, in which ex vivo production of human erythroid progenitor cells from CB was promoted by chrom

108 Furthermore, cultured erythroid progenitor cells from MAM-negative individuals

109 ion using ex vivo differentiation of CD34(+) erythroid progenitor cells from peripheral blood of heal

110 nduction during the rapid expansion of adult erythroid progenitor cells have not been fully elucidate

111 cks the proliferation and differentiation of erythroid progenitor cells in cultured human CD34(+) cel

112 arrow cellularity and decreased frequency of erythroid progenitor cells in the bone marrow consistent

113 s PlGF, and its enforced expression in human erythroid progenitor cells induces PlGF mRNA.

114 ocalized NS1 at the protein level in primary erythroid progenitor cells infected with B19V; and inhib

115 Human erythroid progenitor cells lines have been produced from

116 B19 (B19V) takes place exclusively in human erythroid progenitor cells of bone marrow and fetal live

117 ovirus B19 (B19V) infection is restricted to erythroid progenitor cells of the human bone marrow.

118 ockdown (KD) of PRMT1 by RNA interference in erythroid progenitor cells prevents histone acetylation,

119 pression of these microRNAs in primary human erythroid progenitor cells results in elevated fetal and

120 gonists in stimulating self-renewal of early erythroid progenitor cells suggests that the clinically

121 vitro culture system to expand human stress erythroid progenitor cells that express analogous cell-s

122 tipotent progenitor cells, and megakaryocyte-erythroid progenitor cells that is required under hemato

123 d an accumulation of nuclear p53 staining in erythroid progenitor cells that was not present in contr

124 ata1/GATA1 transcription in murine and human erythroid progenitor cells through an evolutionarily con

125 s by binding to its cell surface receptor on erythroid progenitor cells to stimulate erythrocyte prod

126 is an important regulator of iron update in erythroid progenitor cells via its control of Tfr1 trans

127 transgenic Eto2 null mice and in human CD34+ erythroid progenitor cells with reduced ETO2, loss of ET

128 IE is an abnormal expansion of the number of erythroid progenitor cells with unproductive synthesis o

129 e, we report that, in ex vivo-expanded human erythroid progenitor cells, B19V infection induces a bro

130 Friend virus infects erythroid progenitor cells, followed by an initial polyc

131 in transfection of primary ex vivo-expanded erythroid progenitor cells, in comparison with apoptosis

132 vating the erythropoietin receptor (EPOR) in erythroid progenitor cells, leading to proliferation and

133 g erythroid tropism and drastically destroys erythroid progenitor cells, thus leading to most of the

134 s were markedly decreased in Eklf(-/-) early erythroid progenitor cells, which showed a delay in the

135 example, Myc stimulates the proliferation of erythroid progenitor cells, while the USF proteins and T

136 lentiviral short hairpin RNA transduction of erythroid progenitor cells, with global surface proteomi

137 binding to erythropoietin receptor (Epor) on erythroid progenitor cells.

138 during B19V infection of permissive CD36(+) erythroid progenitor cells.

139 tress response in K562 cell line and primary erythroid progenitor cells.

140 19V) infection is highly restricted to human erythroid progenitor cells.

141 n of p21 and consequent cell cycle arrest in erythroid progenitor cells.

142 ins to promote the Epo-independent growth of erythroid progenitor cells.

143 or (SCF) stimulation in cultured human adult erythroid progenitor cells.

144 bin gene expression in primary CD71-positive erythroid progenitor cells.

145 tosis significantly during B19V infection of erythroid progenitor cells.

146 with RNA from wild-type and Eklf(-/-) early erythroid progenitor cells.

147 EKLF-dependent DNase I sensitivity in early erythroid progenitor cells.

148 while reducing the numbers of megakaryocyte-erythroid progenitor cells.

149 erminal proliferation and differentiation of erythroid progenitor cells.

150 B19 (B19V) has an extreme tropism for human erythroid progenitor cells.

151 -binding protein family that is expressed in erythroid progenitor cells.

152 were also present in downstream myeloid and erythroid progenitor cells.

153 arly steps in the differentiation of myeloid-erythroid progenitor cells.

154 modimers signal to promote the maturation of erythroid progenitor cells.

155 globin genes during differentiation of adult erythroid progenitor cells.

156 n in both K562 cells and primary human adult erythroid progenitor cells.

157 nd repressed their transcription in immature erythroid progenitor cells.

158 ietin (Epo), because the colony-forming unit erythroid progenitors (CFU-Es) that respond to Epo are e

159 ns resulted in the preferential expansion of erythroid progenitors characterized by the expression of

160 gs had distinct effects on the production of erythroid progenitor colonies; dexamethasone selectively

161 ltures, INCB018424 preferentially suppressed erythroid progenitor colony formation from JAK2V617F(+)

162 Abnormality in Meg/E or erythroid progenitors could potentially be considered an

163 Remarkably, Rcor1 null erythroid progenitors cultured in vitro form myeloid col

164 Erythroid progenitor daughter cell pairs have similar tr

165 initiates with rapid expansion of late-stage erythroid progenitors-day 3 burst-forming units and colo

166 p53-deficient mice, thereby ameliorating the erythroid progenitor defect.

167 Lowering LMO2 levels in erythroid progenitors delays G1-S progression and arrest

168 P1 knock-in premegakaryocyte/erythroid progenitors demonstrate an erythroid-specifica

169 -globin gene promoters in GM979 cells and in erythroid progenitors demonstrate that RB7 and butyrate

170 Erythroid progenitors derived from fetal or adult mammal

171 rrested GATA1-deficient murine megakaryocyte-erythroid progenitors derived from murine embryonic stem

172 udi resulted in less severe anemia, improved erythroid progenitor development, and increased survival

173 , to a greater extent, CMP and megakaryocyte-erythroid progenitor development, and red blood cell pro

174 oduced during malaria infection may suppress erythroid progenitor development.

175 Erythroid progenitors differentiate in erythroblastic is

176 posttranslational histone modifications when erythroid progenitors differentiate into late erythrobla

177 As erythroid progenitors differentiate into precursors and

178 -macrophage progenitors and as megakaryocyte-erythroid progenitors differentiated to both megakaryocy

179 NUP98-HOXA9 expression inhibited erythroid progenitor differentiation and delayed neutrop

180 phosphorylation that normally occurs during erythroid progenitor differentiation.

181 TRPC3 expression increases on normal human erythroid progenitors during differentiation.

182 ydrazine revealed a delay in the recovery of erythroid progenitors, early precursors, and normal hema

183 onogenic assays that quantify early and late erythroid progenitor (EEP and LEP) potential, respective

184 both quantitative and qualitative defects in erythroid progenitor (EP) contribute to defective erythr

185 ctor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical Janus

186 s derived from the later colony-forming unit erythroid progenitor erythropoietin (Epo)-dependent prog

187 last (CD71(+) Ter119(-) cells) stage onward, erythroid progenitors exhibited excess heme content, inc

188 ockdown studies confirmed RHEX regulation of erythroid progenitor expansion and further revealed role

189 hropoiesis, we demonstrate that human stress erythroid progenitors express fetal hemoglobin upon diff

190 FOG-1(R3K5A/R3K5A) megakaryocytes and erythroid progenitors expressed increased levels of GATA

191 in embryos with severely reduced Scl levels, erythroid progenitors expressing gata1 and embryonic glo

192 Erythroid progenitors failed to develop normally, showin

193 neage differentiation model of megakaryocyte/erythroid progenitor formation was insufficient for hema

194 population exhibits the properties of stress erythroid progenitors found in adult spleen.

195 One population resembles the steady state erythroid progenitors found in the adult bone marrow.

196 tocytogenesis is enhanced in the presence of erythroid progenitors found within the bone marrow.

197 e marrow and spleen, but it had no effect on erythroid progenitor frequency.

198 Culture of erythroid progenitors from the patient and his parents r

199 SCF/proto-oncogene c-Kit (c-Kit) signaling, erythroid progenitor function, and erythrocyte regenerat

200 depletion of erythroid cells and a defect in erythroid progenitor function.

201 e that lymphoid progenitors, but not myeloid-erythroid progenitors, give rise to NH cells in vivo.

202 common myeloid progenitor and megakaryocytic-erythroid progenitor, granulocyte-monocyte progenitor an

203 athways were analyzed within Spry1-deficient erythroid progenitors, hyperactivation of not only Erk1,

204 poietic stem cells (HSCs) and megakaryocytic erythroid progenitors identified highly up-regulated gen

205 d reduced myeloid multilineage and committed erythroid progenitors in HIF-1alpha-deficient embryos, a

206 tion of a self-renewing population of stress erythroid progenitors in mice suggests that therapeutic

207 We detected normal numbers of primitive erythroid progenitors in Ncx1-/- versus wild type (WT) Y

208 ion, suggesting distinct mechanisms by which erythroid progenitors in polycythemias with defects of h

209 nemia despite adequate numbers of clonogenic erythroid progenitors in the bone marrow and expanded sp

210 rentially affect the expansion of the stress erythroid progenitors in the fetal liver leading to feta

211 pathway plays a key role in the expansion of erythroid progenitors in the fetal liver.

212 hat can be targeted to elevate both HSCs and erythroid progenitors in the local hematopoietic microen

213 acid receptor antagonist increases gata1(+) erythroid progenitors in the posterior mesoderm of wild-

214 mice harbor significantly higher numbers of erythroid progenitors in the spleen compared with wild-t

215 ansion of a specialized population of stress erythroid progenitors in the spleen during the recovery

216 e B and T cells, monocytes, macrophages, and erythroid progenitors in the spleens of p27Kip1-/-; p130

217 Using purified erythroid progenitors in vitro, we show that IL-33 direc

218 E7.25 along with megakaryocyte and primitive erythroid progenitors, indicating that primitive hematop

219 ing, is the most active caspase in apoptotic erythroid progenitors induced by 11 kDa and NS1 as well

220 p process involving differentiation of early erythroid progenitors into enucleated RBCs.

221 Although initial expansion of late-stage erythroid progenitors is dependent on EPO, this cellular

222 is expression pattern is also seen in stress erythroid progenitors isolated from patients with sickle

223 xpression is essential for megakaryocyte and erythroid progenitors, its down-regulation is required f

224 ematopoietic stem cells (HSCs) and committed erythroid progenitors, leading to increased erythroid an

225 ietic Cbfb-deficient mice also lack CD105(+) erythroid progenitors, leading to severe anemia at 3 to

226 In iron deficiency, committed erythroid progenitors lose responsiveness to erythropoie

227 s transcription factors (TFs) in human-mouse erythroid progenitor, lymphoblast and embryonic stem-cel

228 t knockdown of KLF1 in human and mouse adult erythroid progenitors markedly reduces BCL11A levels and

229 Controlled knockdown of KLF1 in adult erythroid progenitors may provide a method to activate f

230 activation is initiated at the Megakaryocyte/Erythroid Progenitor (MEP) stage of differentiation and

231 mmon myeloid progenitor (CMP), megakaryocyte-erythroid progenitor (MEP), and granulocyte-macrophage p

232 e from a shared precursor, the megakaryocyte-erythroid progenitor (MEP), which remains poorly defined

233 ls that arise from a bipotent megakaryocytic-erythroid progenitor (MEP).

234 d its immediate precursor, the megakaryocyte-erythroid progenitor (MEP).

235 topoietic stem cells (HSC) and megakaryocyte-erythroid progenitors (MEP) than low-risk patients, and

236 ose were decreased in purified megakaryocyte/erythroid progenitors (MEPs) from W41/41 mice and rescue

237 Bipotent megakaryocyte/erythroid progenitors (MEPs) give rise to progeny limite

238 biases the commitment of megakaryocytic (Mk)-erythroid progenitors (MEPs) toward the Mk lineage in bo

239 aused by an expansion of fetal megakaryocyte-erythroid progenitors (MEPs) triggered by trisomy of chr

240 yocytic progenitors (MPs) and megakaryocytic/erythroid progenitors (MEPs).

241 marrow environment affects the megakaryocyte-erythroid progenitors (MEPs).

242 s) that arise from bipotential megakaryocyte/erythroid progenitors (MEPs).

243 romote increased quiescence in megakaryocyte-erythroid progenitors (MEPs).

244 cytic progenitors (GMPs), and megakaryocytic-erythroid progenitors (MEPs).

245 unctional equivalents known as megakaryocyte/erythroid progenitors (MEPs).

246 ion, supporting the concept that bone marrow erythroid progenitors migrate to spleen.

247 rrects their hematocrits and deficiencies in erythroid progenitor numbers.

248 roliferation and terminal differentiation of erythroid progenitors occurs in human bone marrow within

249 megakaryocyte and/or bipotent megakaryocyte/erythroid progenitors of bone marrow, hence they are ref

250 tDNA mutations in vivo, we deleted Atg7 from erythroid progenitors of wild-type and mtDNA-mutator mic

251 Culturing erythroid progenitors on recombinant fibronectin fragmen

252 When overexpressed in primary erythroid progenitors, oncogenic Ras leads to the consti

253 ng cells (EPCs), leading to expansion of the erythroid progenitor pool and robust splenic erythropoie

254 s leads to decreased GATA1 expression in the erythroid progenitor population and p53-dependent upregu

255 s characterized by an expanded megakaryocyte erythroid progenitor population that was able to propaga

256 d with decreased levels and functionality of erythroid progenitor populations, defects ameliorated by

257 re activated in P1 knock-in premegakaryocyte/erythroid progenitors, presumably accounting for the inc

258 al, and knockdown of ZFP36L2 in transplanted erythroid progenitors prevented expansion of erythroid l

259 leukemias co-opt miR-486 functions in normal erythroid progenitor progrowth and survival activity.

260 hropoiesis is the process by which nucleated erythroid progenitors proliferate and differentiate to g

261 To meet this need, erythroid progenitors rapidly expand in the fetal liver

262 homeostasis in the body, TFR2's function in erythroid progenitors remains controversial.

263 se mice and the precise function of c-Myb in erythroid progenitors remains elusive.

264 down of Mbnl1 in cultured murine fetal liver erythroid progenitors resulted in a strong block in eryt

265 ds to expansion of myeloid cells and reduced erythroid progenitors resulting in anemia, with dysregul

266 CL11A) downregulation in human primary adult erythroid progenitors results in elevated expression of

267 Gene expression profiling of Fog(ki/ki) MK-erythroid progenitors revealed inappropriate expression

268 Immature stress erythroid progenitors (SEPs) are derived from short-term

269 igands that initiate the expansion of stress erythroid progenitors (SEPs) in the spleen.

270 Commensurately, HSC and megakaryocyte-erythroid progenitors show higher clonogenicity, with in

271 Of importance, p67 recognizes early erythroid progenitors, since sorted p67(+) cells were si

272 enitors, acting in vivo at the megakaryocyte-erythroid progenitor stage to skew development away from

273 crucial functions: (1) at the megakaryocyte-erythroid progenitor stage, where it is involved in eryt

274 entiation of erythrocytes was blocked at the erythroid progenitor stage.

275 oid (CFU-Es) activities and reduced immature erythroid progenitors, suggesting that Cdc42 deficiency

276 thought to arise from bipotent thrombocytic/erythroid progenitors (TEPs).

277 in the spleen of a specialized population of erythroid progenitors termed stress BFU-E.

278 mosaic UPD of the beta-globin locus, more SS erythroid progenitors than AS, but a reverse ratio of er

279 xl1(f/f) (Asxl1(/)) mice had less numbers of erythroid progenitors than Asxl1(f/f) controls.

280 lt in an initial expansion of mutant HSC and erythroid progenitors that are later depleted as more di

281 raction is disrupted (Fog(ki/ki)) produce MK-erythroid progenitors that give rise to significantly fe

282 ntially expand ES cell-derived megakaryocyte-erythroid progenitors that have the capacity to differen

283 BM ALDH(hi) cells were enriched for myelo-erythroid progenitors that produced multipotent hematopo

284 Despite a severe depletion of erythroid progenitors, the erythrocyte and megakaryocyte

285 ia stimulates the proliferation of wild-type erythroid progenitors, the proliferation of progenitors

286 (1) are the principal integrins expressed on erythroid progenitors; their down-regulation during eryt

287 we analyzed the response of normal enriched erythroid progenitors to inducible disruption of a floxe

288 s that involves the differentiation of early erythroid progenitors to mature erythrocytes.

289 as it changes from a poised, silent state in erythroid progenitors, to the fully activated state in l

290 ach anemia model, however, hyperexpansion of erythroid progenitors was observed.

291 By culturing fetal liver erythroid progenitors, we show that fibronectin and Epo

292 Early erythroid progenitors were closely associated with peris

293 Megakaryocyte and late erythroid progenitors were dramatically increased, with

294 nted hypoxia-inducible factor activity whose erythroid progenitors were hypersensitive to EPO.

295 ony activity and numbers of CD71(+)Ter119(+) erythroid progenitors were severely reduced.

296 throblastic islands remained unrecognized as erythroid progenitors were shown to possess an autonomou

297 l relevance of these findings, human primary erythroid progenitors were treated with HDAC9 siRNA; we

298 e development of three populations of stress erythroid progenitors, which expanded in the spleen subs

299 ial of JAK2(V617F)-expressing cell lines and erythroid progenitors while moderately affecting normal

300 ce markers that delineate a series of stress erythroid progenitors with increasing maturity.