ライフサイエンスコーパス: escalate

1 s and disease-associated costs continuing to escalate.

2 e industry can avert these costs before they escalate.

3 1.5 mg if >/=60 kg) and therapy is gradually escalated.

4 Venetoclax dose initially was escalated (100-400 mg) in a 3 + 3 design to define MTD c

5 apy, received intraperitoneal treatment with escalating (20-215 MBq/L) activity concentrations of (21

6 FVII-G96E dogs received escalating AAV doses (2E11 to 4.95E13 vector genomes [vg

7 ally on days 1, 3, 8, 10, 22, and 24 and was escalated according to a rolling-six design.

8 teases was conserved, alkaloid diversity has escalated across the studied species, oxidative activity

9 131)I-omburtamab as a single IP injection at escalated activities from 1.11 to 3.33/GBq/m(2).

10 Activity-escalated acute and chronic toxicity studies of (225)Ac-

11 Only 3 patients de-escalated after a positive UAT result were subsequently

12 Only 3 patients de-escalated after positive UAT were subsequently admitted

13 roversy over the authenticity of these silks escalated after the purchase of the silks by museums thr

14 PFC, interacted with prior alcohol intake to escalate aggression in ANAs.

15 described 14 techniques used in response to escalated aggression applied on a continuum between supp

16 1, individuals were less likely to engage in escalated aggression in contest 2.

17 Escalated aggression is a behavioral sign of numerous ps

18 The neurobiology underlying escalated aggression is unknown and is particularly unde

19 erstanding staff intervention in response to escalated aggression, a continuum between support and co

20 adaptive value by reducing the potential for escalated aggression, benefiting both senders and receiv

21 for preclinical studies of the treatment of escalated aggression, with the added benefit that emergi

22 ring the pre-escalation phase but not during escalated aggression.

23 nt aggression, and required to manage and de-escalate aggressive incidents; coercive measures such as

24 The inoculum dose was escalated aiming to colonise at least 70% of participant

25 The inoculum dose was escalated, aiming to colonize at least 70% of participan

26 nt memory, i.e., limbic memory, that promote escalated alcohol consumption and relapse.

27 kappa opioid receptor-mediated signaling in escalated alcohol consumption associated with dependence

28 raperitoneal oxytocin administration blocked escalated alcohol drinking and the enhanced motivation f

29 ohol's effects on CeA activity and drive the escalated alcohol intake of alcohol-dependent rats.

30 ohol's effects on CeA activity and drive the escalated alcohol intake of alcohol-dependent rats.

31 tent alcohol vapor exposure that resulted in escalated alcohol self-administration and elevated physi

32 arify the nature of the stimulus that drives escalated alcohol self-administration during acute withd

33 ecific KOR antagonism in the CeA ameliorated escalated alcohol self-administration during both acute

34 These results dissociate escalated alcohol self-administration from physiological

35 at drives dependence-like phenotypes such as escalated alcohol self-administration.

36 Alcohol tolerance is a key step toward escalating alcohol consumption and subsequent dependence

37 eptive encodings from being decoded, whereas escalated amplification through the recruitment of secon

38 Measurements were made during wakefulness, escalating and constant levels of two anesthetic agents

39 The burden of hypertension is escalating, and control rates are poor in low- and middl

40 was induced with the use of corticosteroids, escalated anti-TNF therapy and eventually anti IL-12/23

41 on of baseline antiarrhythmic medications or escalated antiarrhythmic drug therapy (escalated-therapy

42 sting (AST) is a critical need in addressing escalating antibiotic resistance, since delays in identi

43 opportunity for assessing the effects of de-escalating anticancer regimens, which may fast-forward t

44 important strategy in efforts to address the escalating antimicrobial resistance crisis.

45 7-beta-estradiol benzoate (EB) restored this escalated anxiety-like behavior in TTC9A(-/-) mice.

46 and which creates cognitive conditions that escalate arousal and quickly results in task failure (e.

47 nt costs begins in earlier stages of CKD and escalates as kidney function declines.

48 source intensive process whose scale quickly escalates as more drugs can be combined.

49 vanced imaging for eye-related ED visits has escalated at a higher rate than ED visits for eye compla

50 conducted, starting at 10(7) total cells and escalating at half-log increments to approximately 10(11

51 that increased bacterial genotypic richness escalates bacterial antagonism and decreases the ability

52 Counteracting escalating barrier breaks, plasma exudation promptly cov

53 The dose was escalated based on tolerance or safety data from higher

54 Among smokers CMH prevalence escalated between ages 36 and 43 from 7.6 +/- 2.0% to 13

55 ts not achieving CR on PET2 were switched to escalated bleomycin, etoposide, doxorubicin, cyclophosph

56 ts (Deauville score 4 to 5) were switched to escalated bleomycin, etoposide, doxorubicin, cyclophosph

57 With an escalating burden of infections and the relative failure

58 Liraglutide or placebo was escalated by 0.6 mg/day each week for 5 weeks and contin

59 500 mg/m(2) per day; the dose level was then escalated by doubling the previous dose if there were no

60 l the Rapid Response Team can cause delay in escalating care.

61 (SCI), the initial damage leads to a rapidly escalating cascade of degenerative events, known as seco

62 ction with UNC5B, diminishing YAP levels and escalating cell deaths.

63 Amphetamine treatment also reversed escalated cocaine intake and decreased motivation to obt

64 by decreased cocaine-induced locomotion and escalated cocaine intake despite extended abstinence fro

65 These findings indicate that withdrawal from escalated cocaine SA disrupts how negative feedback is u

66 elease during stress may contribute to later escalated cocaine taking, and that persistently elevated

67 he deltoid or quadriceps in one of four dose-escalating cohorts (group A, 4 x 10(12) vector genomes;

68 The trial was subsequently revised to escalating cohorts of 5 patients treated every 2 weeks x

69 e propagated influenza A virus in vitro with escalating concentrations of antibody and analyzed viral

70 IAV was propagated with escalating concentrations of F10 over serial passages in

71 across the northeastern United States is an escalating concern threatening the ecological health of

72 ned with parental control over marriages may escalate conflict between same-sex siblings who compete

73 Identifying and de-escalating conflict before it become intractable is a pr

74 Mortality risk escalated continuously with increasing number of metasta

75 diovascular clinical trials are plagued with escalating costs and low enrollment.

76 The complexity and escalating costs associated with the synthesis of more c

77 merican College of Physicians to address the escalating costs of prescription drugs in the United Sta

78 ource of morbidity in the U.S., with rapidly escalating costs to the health care system.

79 In the context of rapidly escalating Covid-19 outbreaks, proactive steps by long-t

80 atory, and funding solutions to address this escalating crisis.

81 VR rats showed escalating DA overflow with increasing ratios.

82 26); or 3) tidal ventilation with an initial escalating/de-escalating (dynamic) positive end-expirato

83 ng these two pivotal players, in addition to escalating delta-secretase activity to cleave alpha-Syn

84 standard life-saving medical resources when escalating demand outstrips supply.

85 insomnia, a novel way to reduce the risk of escalating depression might be to offer an insomnia inte

86 Threats to Antarctic biodiversity are escalating, despite its remoteness and protection under

87 rldwide medicinal use of cannabis is rapidly escalating, despite limited evidence of its efficacy fro

88 ls for high-throughput chemistry offering an escalating diversity of warheads, opportunities for inno

89 ivers for transplant, solving the problem of escalating donor shortages.

90 and Methods Adult patients were treated with escalating dosages of BGJ398 5 to 150 mg once daily or 5

91 ), consistent high dose (150 mg MED, 15.0%), escalating dose (from <3 to 20 mg MED, 13.7%), and de-es

92 g dose (from <3 to 20 mg MED, 13.7%), and de-escalating dose (from 20 to <3mg MED, 9.4%).

93 Three escalating dose levels (DL) were administered IM in 8 su

94 eive high-dose MTX with leucovorin rescue or escalating dose MTX with PEG asparaginase without leucov

95 effect was most profound with a continuous, escalating dose of factor VIIa.

96 ntiangiogenic effect of TNF observed with an escalating dose of this cytokine, as well as the effect

97 ats before and after they were exposed to an escalating dose regimen of MA (or saline control).

98 saline by i.p. injections for 5 days with an escalating dose regimen.

99 Triac was administered in a predefined escalating dose schedule-after the initial dose of once-

100 Escalating dose-response experiments on primary VS cells

101 s infusion of placebo or OM in 3 sequential, escalating-dose cohorts.

102 rt B) with an interactive response system to escalating-dose subcutaneous IONIS-APO(a)Rx (100 mg, 200

103 re (18)F-FMISO-positive, 24 of whom received escalated doses of up to 86 Gy.

104 mice that received vehicle or Delta9-THC in escalating doses (2.5-10 mg/kg/ip) through adolescence (

105 We gave escalating doses (from 40-240 mg once daily to 160 mg tw

106 Avadomide was administered in escalating doses and two formulations: active pharmaceut

107 Lorlatinib 100 mg once daily (escalating doses of 10 mg once daily to 100 mg twice dai

108 rst 60 participants were given sertraline at escalating doses of 100 mg/day, 200 mg/day, 300 mg/day,

109 r patients with allergies begins with weekly escalating doses of allergen under medical supervision t

110 measure serum/renal tissue AP activity with escalating doses of AP infusion, and provide preliminary

111 Thereafter, patients received escalating doses of axitinib (2-10 mg) plus flat dose pe

112 Groups were treated with escalating doses of bovine intestinal AP (1, 5, or 25U/k

113 Patients received escalating doses of EV up to 1.25 mg/kg on days 1, 8, an

114 tial AZA (75 mg/m(2) for 7 days) followed by escalating doses of LEN on days 10 to 30.

115 Patients received escalating doses of mavorixafor, up to 400 mg once daily

116 nce was induced in rodents by treatment with escalating doses of morphine.

117 Concurrent cohorts 1, 2, 2a, and 3 received escalating doses of NIVO plus IPI once every 3 weeks for

118 oth lean and obese participants, infusion of escalating doses of obestatin resulted in a progressive

119 ients were treated in cycles of 28 days with escalating doses of oral umbralisib (400, 600, or 800 mg

120 dard 3 + 3 phase I design, patients received escalating doses of sunitinib, in 100 mg increments, sta

121 Escalating doses were given to subsequent cohorts, and o

122 increase in their circulating platelets with escalating doses.

123 d 2:1 to vaccine or normal saline placebo in escalating doses: 1.35 x 105, 2.7 x 105, 4.5 x 105, 9.0

124 d 2:1 to vaccine or normal saline placebo in escalating doses: 1.35x105, 2.7x105, 4.5x105, 9.0x105, a

125 the use of Ixekizumab requiring rescue with escalated dosing of anti-TNF therapy and highlights the

126 significantly lower among children receiving escalated dosing than among those receiving a fixed dose

127 baseline and after follow-up, identifying 18 escalating drinkers and 18 constant drinkers.

128 fundamental link between stress history and escalated drug self-administration.

129 concentrations from agricultural lands will escalate during large hydrological events, which can exa

130 proportion of patients in whom treatment was escalated during follow-up over 14 mo, and case detectio

131 al ventilation with an initial escalating/de-escalating (dynamic) positive end-expiratory pressure (D

132 immunomodulatory therapies have resulted in escalating efforts to successfully treat highly sensitiz

133 The potential benefit of escalating endocrine therapy versus tamoxifen alone is m

134 leading to its cytoplasmic translocation and escalated enzymatic activities.

135 randomized controlled trials comparing dose-escalated external beam radiation therapy (EBRT) with br

136 The dose of cedazuridine was escalated first and decitabine was escalated once CDA in

137 rally located NSCLC were accrued into a dose-escalating, five-fraction SBRT schedule that ranged from

138 were designed to mimic tumor progression by escalating flow complexity and chaoticity.

139 ighlighted the importance of two potentially escalating forces that oppose TE spread: regulated trans

140 This escalating frame requires agents to continuously balance

141 Intravenous LY2606368 was dose escalated from 10 to 50 mg/m(2) on schedule 1 (days 1 to

142 The dose was gradually escalated from 103 colony forming units (0% colonised) t

143 The dose was gradually escalated from 103 colony-forming units (0% colonized) t

144 , administered after oral THU 10 mg/kg, were escalated from a very low starting level (0.01, 0.02, 0.

145 based on treatment of 43 patients with doses escalating from 50 to 150 mg daily for 12 weeks.

146 ediction accuracy consistently improves when escalating from linear models to shallow-nonlinear model

147 expected rise in prevalence in line with the escalating global burden of obesity.

148 An escalating global campaign to end early marriage typical

149 Escalating global water scarcity necessitates high-perfo

150 availability of community-based providers to escalate HCV therapy, bridging existing gaps in the cont

151 Escalating health care costs together with questionable

152 he-Dark-Multiple Scheduled Access) to induce escalating heavy binge drinking and anxiety-like behavio

153 et al describe a single-arm trial using dose-escalated hydroxyurea and regular transfusions to preven

154 e therapeutic potential of varenicline would escalate if it also diminished conditioned responses eli

155 (hourly, in both of which the dose could be escalated if hypertension was maintained), or 1000 mg me

156 The drug dose was escalated if mean decitabine area under the curve (AUC)

157 First, can one expect that fiber functions escalate in a predictable manner, creating the context f

158 E-cigarette use continues to rapidly escalate in the USA, particularly among youth.

159 AAMs were escalated in 158 (17.5%), de-escalated in 351 (39.0%), a

160 AAMs were escalated in 158 (17.5%), de-escalated in 351 (39.0%), and were unchanged at 6-month

161 In both groups, treatment was escalated in a stepwise manner, from no treatment, to ad

162 ed after pathogen clearance and irreversibly escalated in severity with repeated infections.

163 aily schedule and 60 mg for other schedules, escalating in 30 mg increments.

164 y associated with prescription opioid use is escalating in the United States.

165 Importance: An escalating incidence of human papillomavirus (HPV)-relat

166 1 dose-escalation cohorts for each histology escalated independently in a standard 3 x 3 design.

167 Patients were treated at escalating injected activities (10, 15 and 20 MBq/kg) of

168 tes the key criteria of opioid use disorder: escalated intake, highly motivated responding, and hyper

169 Here we demonstrate that escalating, intermittent stress increases Rap1 in mouse

170 ficiency and staff anxiety had a key role in escalating intervention.

171 between stages showed how an index case can escalate into a widespread epidemic in the absence of in

172 specific effects reported previously did not escalate into higher-level systemic structural change in

173 what begins as small acts of dishonesty can escalate into larger transgressions.

174 The resulting positive feedback cycle escalates into bulimia for many, and anorexia in a few.

175 me [e.g., 5] or partners [6], then gradually escalating investments in more cooperative partnerships

176 ion of both the nonpathogenic ALV-E and SB-1 escalates it to much higher levels.

177 C/EBPbeta binds the promoter of APOE and escalates its expression in the brain.

178 Intermittent social defeat stress escalates later cocaine self-administration.

179 day for 21 days per 28-day cycle, with a de-escalated level of 3 mg if not tolerable, and aspirin 81

180 ing environmental concerns of our age is the escalating level of atmospheric CO2 .

181 immunological analysis revealed massive and escalating levels of T-cell activation.

182 (212)Pb-L2 was also evaluated for dose-escalated, long-term toxicity.

183 lling evidence that vampire bats selectively escalate low-cost grooming before developing higher-cost

184 In young adults, an escalating MaxDrinks trajectory was prospectively associ

185 These mice were chronically treated with an escalating Meth regime during late adolescence.

186 associated with decreased M2 macrophages and escalated microbial imbalance.

187 6 mg/kg intravenously every 3 weeks and dose-escalating neratinib at 120, 160, 200, or 240 mg/d orall

188 marketing, do-it-yourself enthusiasm, and an escalating number of clinical trials.

189 ckievirus A10 (CV-A10) is responsible for an escalating number of severe infections in children, but

190 of exercise, have likely contributed to the escalating numbers of adults who have embraced the notio

191 Ratios were escalated on successive sessions and rats maintained on

192 idine was escalated first and decitabine was escalated once CDA inhibition by cedazuridine approached

193 ve breast cancer who might be candidates for escalated or de-escalated systemic treatment.

194 ion of patients who will benefit from either escalated or de-escalated treatment will be crucial to t

195 had higher grade surgeries but none required escalated or intensive care treatment related to COVID i

196 y worsening abdominal pain in the context of escalating or continuous opioid therapy.

197 patients were assigned to cohorts to receive escalating oral doses of decitabine and cedazuridine.

198 goods, risk and reward are often coupled and escalate over time, for instance, during foraging, tradi

199 The prevalence of peanut allergies has escalated over the last 20 years, yet there are no FDA a

200 COVID-19 response in the health sector will escalate, particularly if transmission increases.

201 Use of escalated peptide mass and nephroprotective agents were

202 With the escalating persuasion of economic and nutritional import

203 al access and public acceptance of marijuana escalate, physicians should be aware of these perception

204 ke hold and may be the primary driver of the escalating poleward migration of species.

205 mics are an important evolutionary driver of escalating predation mode and efficiency, and commensura

206 e global control of enteric fever due to the escalating problem of antimicrobial resistance.

207 The escalating problem of obesity and its multiple metabolic

208 t initiation of ADT in combination with dose-escalated prostate RT (PRT).

209 rent initiations of short-term ADT with dose-escalated PRT are reasonable standards of care for LPCa.

210 ent Bordetella pertussis In response to this escalating public health concern, the National Institute

211 he response ratio (lever presses per reward) escalated, Q175 mice exerted less effort to earn fewer r

212 Adapting RT-escalated radiation dose to the FDG-avid tumor detected

213 Dose-escalated radiotherapy (RT) with androgen-deprivation th

214 ted AKT suppresses MRN complex expression to escalate RAS-induced DNA damage and thereby reinforce on

215 in the orbitofrontal cortex of high cocaine-escalating rats.

216 ctive oxygen species was associated with the escalated regulation of the fatty acid metabolism networ

217 the current era of burdensome regulation and escalating research costs.

218 We found that as hunger state escalated, resident animal social interactions with eith

219 Escalating resistance in animals is anticipated to have

220 by bed nets has precipitated widespread and escalating resistance to pyrethroids in African Anophele

221 experience in female hamsters resulted in an escalated response to future aggressive encounters and a

222 nation of smaller and larger infarctions may escalate risk for cognitive decline later in life in str

223 We identified low but escalating risk of severe M. chimaera infection associat

224 ng a die to accumulate monetary reward under escalating risk, or the alternative option to stop to ba

225 ce immunity, microbiota might have played an escalating role in the evolution of sociality.

226 up performance status, 0 to 1) received dose-escalated RT to 70 to 90 Gy (median, 74 Gy) in six trial

227 ocoregional control, local control with dose-escalated RT, pattern of failure, and adverse effects.

228 The escalating scale of millet consumption on the eastern Eu

229 ld with both motor and non-motor symptoms of escalating severity as it progresses.

230 represent a major human health problem with escalating social cost.

231 the fiduciary responsibilities of payers and escalating spending on health care and pharmaceuticals,

232 , which is accessed via energetically small, escalating steps in which the ground-state keto-isomer i

233 ogression of nontarget lesions, new lesions, escalating steroids, progressive neurologic signs or sym

234 Dopamine depletion escalated striatal net output but had contrasting effect

235 This was a phase 1, open-label, dose-escalating study done at four outpatient retina clinics

236 ized, double-blind, placebo-controlled, dose-escalating study of BMS-936559, including HIV-1-infected

237 en-label, single-center, intra-patient, dose-escalating study, adult patients with HPP received 3 asc

238 who might be candidates for escalated or de-escalated systemic treatment.

239 Normal aging is accompanied by escalating systemic inflammation.

240 in both frequency and intensity, which will escalate the amount of terrestrial run-off and mechanica

241 have the potential to decrease toxicity and escalate the dose to the bone marrow for high-risk patie

242 enomic data can be generated has drastically escalated the computational burden for even routine phyl

243 e and other data-intensive applications have escalated the demand for data storage and processing.

244 uclear accidents or terrorist activities has escalated the need for radiation countermeasure developm

245 and immune system cross-modulate each other, escalating the destructive feedback cycle between them t

246 blems regarding toxicity and immunogenicity, escalating the need for an alternative.

247 recurrent shocks and reassemble afterwards, escalating the risk of widespread ecological collapse of

248 We further show that when cancer incidence escalates, the average PAC drops below the isometric PAC

249 more alcohol than controls and spontaneously escalate their consumption.

250 g interest to develop new schemes to further escalate their performance.

251 ancy rate, and the unemployment rate) people escalate their support for dominant leaders.

252 he proportion of patients who could first de-escalate their treatment for 12 months, and then stop tr

253 ostoperative patient in a simulated ward and escalated their care to a senior colleague.

254 ccess (ShA; 1 h/day) to vaporized sufentanil escalated their drug intake over time and exhibited both

255 Our findings suggest de-escalated therapy may be the preferred and potentially m

256 the ablation group and 68.5% of those in the escalated-therapy group (hazard ratio in the ablation gr

257 ns or escalated antiarrhythmic drug therapy (escalated-therapy group).

258 In the escalated-therapy group, amiodarone was initiated if ano

259 ects and one from hepatic dysfunction in the escalated-therapy group.

260 ssigned to the ablation group and 127 to the escalated-therapy group.

261 New strategies are needed to counter the escalating threat posed by drug-resistant fungi.

262 conservation projects confront immediate and escalating threats with limited funding.

263 cribed hemocompatibility score, which uses 4 escalating tiers of hierarchal severity to derive a tota

264 in the reacting octopus were more likely to escalate to grappling.

265 ), once-daily subcutaneous liraglutide (dose escalated to 1.8 mg), or placebo for 52 weeks.

266 function, to receive oral semaglutide (dose escalated to 14 mg once daily) or matching placebo for 2

267 origin, to once-daily oral semaglutide (dose escalated to 14 mg), once-daily subcutaneous liraglutide

268 ne 20 mg, and panobinostat 10, 15, or 20 mg (escalated to 20 mg according to the escalation schedule)

269 (2.) Results: The activity concentration was escalated to 215 MBq/L without any dose-limiting toxicit

270 ose (4.0 mg CH5126766 twice per week) was de-escalated to 3 weeks on followed by 1 week off if patien

271 each 28-day cycle (20 mg/m(2) initial dose, escalated to 70 mg/m(2) thereafter) and dexamethasone (4

272 rting dose was 60 mg/day orally but could be escalated to 80 mg if the patient did not experience a r

273 changed from daily to 10 days per cycle and escalated to 800 mg.

274 for 12 weeks at an initial dose of 50 mg/d (escalated to a maximum dose of 200 mg/d based on tolerab

275 gent anti-PD-1 therapy and 11 of 44 patients escalated to anti-PD-1 plus ipilimumab.

276 roxycarbamide at 20 mg/kg per day, which was escalated to each participant's maximum tolerated dose.

277 n glatiramer acetate or interferon beta were escalated to fingolimod, alemtuzumab, or natalizumab wit

278 TKI treatment was de-escalated to half the standard dose for 12 months, then

279 74 (19%) of 400 were escalated to immunomodulators alone, 123 (31%) anti-TNFa

280 fixed risk of RILT (grade >2) and adaptively escalated to the residual tumor defined on midtreatment

281 tenance was started with 5 mg daily, and was escalated to the target dose of 15 mg.

282 rting dose was two capsules (10 mg) per day, escalated to three capsules (15 mg) per day after 3 mont

283 /kg thereafter; and docetaxel at 75 mg/m(2), escalating to 100 mg/m(2) if tolerated.

284 ified dose (300 mg twice daily continuously, escalating to 400 mg twice daily if tolerated) until dis

285 during relationship formation might involve escalating to more costly behaviors.

286 elated with their response to host defences: escalating traits largely affected generalists and diver

287 ergent traits specialists; but the effect of escalating traits on extreme specialists was positive.

288 uld not be viewed as a reason to avoid or de-escalate treatment for hypertension.

289 who will benefit from either escalated or de-escalated treatment will be crucial to this approach.

290 t was also associated with increased odds of escalating treatment (OR, 3.0; 95% CI, 2.4-3.7).

291 ents offers the possibility of commencing or escalating treatment at an earlier stage.

292 of patients; thus, focus has been placed on escalating treatment by either combining different HER2-

293 countries, such as Brazil, have reported an escalating trend of imported malaria cases from Venezuel

294 function of sampling, closely resembling an escalating urgency signal.

295 d (2) chronic changes in behavior, including escalated use, tolerance, compulsive seeking, and depend

296 AZD1775 was dose escalated using a time-to-event continual reassessment m

297 d NPCs, and loss of this function results in escalated Vegfa and Igf2 signaling, which exacerbates bo

298 Cox's Bazar District, Bangladesh, following escalated violence by Myanmar security forces.

299 Therefore, as thermal fluctuations escalate with global warming, the feminization of TSD tu

300 the studied species, oxidative activity has escalated within one clade, and trichomes have diverged