ライフサイエンスコーパス: escort

1 ChEL domain may also function as a molecular escort.

2 n which one strand includes terminal polymer escorts.

3 al sorting complexes required for transport (ESCORT-0) component, as a downstream target of mTORC1.

4 a tumor proportion score (CheckMate-648 and ESCORT-1st), no significant benefit in OS was observed w

5 he randomized clinical trials CheckMate-648, ESCORT-1st, KEYNOTE-590, ORIENT-15, KEYNOTE-181, ESCORT,

6 To address these challenges, we developed Escort, a novel framework for evaluating a dataset's sui

7 ase elongation factor-1 alpha (eEF1A), which escorts aa-tRNA as an eEF1A(GTP)-aa-tRNA ternary complex

8 protein, regulates its protein unfolding and escort activities.

9 ix bundle, is sufficient to reconstitute the escort activity.

10 ATR is also a chaperone that escorts AdoCbl, transferring it to methylmalonyl-CoA mut

11 As for other histones, escort and deposition of CenH3 must be ensured by histon

12 Mis18 to receive CENP-A(Cnp1) from the Sim3 escort and mediate assembly of CENP-A(Cnp1) into subkine

13 these findings indicate that p53 dynamically escorts and loads TFIID onto its target promoters.

14 nding, followed by chaperoning, matchmaking, escorting, and reduced ER stress.

15 These results validate the notion that "escort aptamers" may be useful for the treatment of spec

16 t swirling may be understood in terms of the escort behavior, when an individual animal tries to resi

17 through direct protein-protein interactions, escorts beta2 signaling to remove Kv1.1 from the dendrit

18 secreted by virtually every cell, and their escorted biomolecules are part of an intercellular infor

19 The polymer escorts both confer protection against nucleases and fac

20 We show that ejecting mycobacteria are escorted by a distinct polar autophagocytic vacuole.

21 orylation by the kinase ACK1/TNK2, pSHP2 was escorted by androgen receptor (AR) to chromatin, erasing

22 Newly synthesized histones are escorted by histone chaperones that mediate their orderl

23 reveal that the metal-centered oxidation is escorted by iron nitride (Fe N) bond elongation, which i

24 barriers to large molecules unless they are escorted by specific LCD containing nuclear transporters

25 Sec61 trimeric complex back to the cytosol, escorted by the beta subunit of Sec61, and degraded by t

26 ng of the mechanisms by which such materials escort cargo from the cell surface to the nucleus.

27 divide only to maintain a constant germ cell:escort cell ratio.

28 Three escort cell subtypes reside in discrete anatomical posit

29 bule-rich cell membranes pass cysts from one escort cell to the next.

30 iferative follicle cells (FCs) and quiescent escort cells (ECs) by follicle stem cells (FSCs) in adul

31 Recently, we have proposed that escort cells (ECs) form a differentiation niche to contr

32 s demonstrate that Lsd1 functions within the escort cells (ECs) that reside immediately adjacent to c

33 FCs) from their posterior face and quiescent Escort Cells (ECs) to their anterior.

34 Signal integration involves escort cells (ECs), which promote differentiation of the

35 ted germ cells that interact physically with escort cells (ECs).

36 filament cells (TFCs), cap cells (CpCs), and escort cells (ECs).(19) We report that niche architectur

37 perform lineage tracing of subpopulations of escort cells and follicle cells.

38 Additionally, escort cells are not replenished by the regular division

39 We discover that a distinct subpopulation of escort cells is able to convert to follicle stem cells i

40 agonist of Brk, is upregulated by Brk in the escort cells of the germarium, demonstrating that Brk ca

41 We show that escort cells produce both Wingless and Hedgehog ligands

42 Rather, escort cells remain quiescent and divide only to maintai

43 In addition, we show that multiple escort cells simultaneously encapsulate germ cell cysts

44 Adult-specific knockdown of dpp in escort cells substantially rescued piwi tumors, demonstr

45 By contrast, in ovarian somatic cap and escort cells Yb body assembly does not require flam tran

46 rmingled cells (ICs, the progenitor cells of escort cells).

47 dynamic population of stromal cells, called escort cells, are FSC niche cells.

48 that loss of Piwi causes defects in ICs and escort cells, leading to ectopic Dpp signaling and conse

49 Somatic escort cells, the glial-like partners of early germ cell

50 We uncovered an unanticipated diversity of escort cells, the somatic cells that directly interact w

51 and previously undescribed subpopulations of escort cells.

52 e in ovarian niche function, and acts within escort cells.

53 doplasmic reticulum protein, functions as an escort chaperone and in protein folding.

54 model describing the mechanism by which U21 escorts class I MHC molecules to the lysosomal compartme

55 he family of metallochaperone molecules that escort copper to distinct intracellular targets.

56 we report that the small molecule elesclomol escorted copper to the mitochondria and increased cytoch

57 of [8(+)][X(-)] by MCHE(2) (E = ester, M = 'escort' counterion, X = Pd allyl counterion) show the sa

58 yltransferase (ATR), which also serves as an escort, delivering AdoCbl to methylmalonyl-CoA mutase (M

59 t cells derived from stem cell divisions and escorting differentiating spermatogonia, a distinct popu

60 aken together, these findings show that p130 escorts E2F4 into the nucleus and, together with corepre

61 Moreover, the universality of "escort effect" is identified by using Cr(3+) and Co(2+)

62 erpotential deposition (UPD), we propose an "escort effect" of electrolyte additives for uniform Zn d

63 how that by releasing an additional tailored escort electron beam at a later phase of the acceleratio

64 Escort evaluates the suitability of trajectory analysis

65 ERp29 was also suggested to act as an escort factor by binding to the secretory protein thyrog

66 The escort factor Scap is essential in mammalian cells for r

67 n (3WJ) of bacteriophage phi29 motor pRNA to escort folic acid, a fluorescent image marker and BRCAA1

68 A role for eRF3 as an escort for eRF1 into its fully accommodated state is eas

69 a not only affirm the role of arrestin as an escort for signaling molecules such as Src family kinase

70 We show that this escort function likewise depends on ERp29 dimerization.

71 is believed to play an important role in the escort function of RAP, because RAP binds tightly to pro

72 Both the "escort" function provided by ABD and the inhibitor funct

73 We then escorted him to the packed lecture hall, and Dr. Sabisto

74 Histone chaperones, which are proteins that escort histones throughout their cellular life, are key

75 histone chaperones play an important role in escorting histones to and from sites of nucleosome assem

76 rse functions that are primarily involved in escorting histones to assemble nucleosomes and maintain

77 Once assembled the small TIM complexes escort hydrophobic inner membrane proteins en route to t

78 chema, mature gL returns to the ER, where it escorts immature gH from the ER to the Golgi; thereafter

79 es through the use of appropriately designed escort/inhibitors.

80 chaperone proteins but not nucleic acids to escort intermediates to correct conformations.

81 (NLS) and utilizes the pAP as an NLS-bearing escort into the nucleus.

82 ery of the nucleophile can be facilitated by escort ion (M) binding to the concave orientated amide c

83 Escort is implemented in an accessible R package and R/S

84 nds to the low-density lipoprotein receptor, escorting it to its destruction in the lysosome and ther

85 synaptic terminals of motor neurons and then escorts it across the synaptic cleft.

86 te conditions before irradiation and rapidly escorts it to the damaged DNA after UV irradiation in a

87 analyses indicate that NAF1 binds NAP57 and escorts it to the nascent H/ACA RNA and that GAR1 then r

88 PDD was shown to escort LAmB to APCs in vivo, enhanced the drug efficacy

89 dblocks is more consistent with a sequential escort mechanism than stochastic, hand-off, or concerted

90 that ARH facilitates endocytosis of megalin, escorts megalin along its endocytic route and raise the

91 The murine CMV (MCMV) immunoevasin m04/gp34 escorts MHC class I (MHC I) molecules to the surface of

92 mCMV recombinant lacking the m04 gene, which escorts MHC class I to the cell surface, showed superior

93 sive relationship with a single helper (its "escort"), minimizing competition over food allocation.

94 n cultured cells, M10s appear to function as escort molecules in transport of V2Rs to the cell surfac

95 Escort navigates single-cell trajectory analysis through

96 We then place them into an escort network that distributes these histones in variou

97 02 family member is m04, a glycoprotein that escorts newly assembled MHC-I molecules to the cell surf

98 tors are required to authenticate, bind, and escort NLS-NCs through NPCs while Ran guanosine triphosp

99 dy suggests that CPSF6 interacts with NP1 to escort NP1 imported into the nucleus for its function in

100 ioxidant response element (ARE) signaling by escorting nuclear export of Nrf2.

101 sts as a ribosome-unbound complex during the escort of aberrant peptides to the proteasome.

102 ion for NKD2, i.e., myristoylation-dependent escort of TGF alpha to the basolateral plasma membrane o

103 ropose that the Hat2p/Rbap48 family serve as escorts of histone metabolism enzymes to facilitate thei

104 om the top staircase position to the bottom, escorting one nucleotide of single-stranded DNA through

105 c intermediates were identified, defining an escorted path followed by malonyl groups en route from C

106 Immunoglobulin-like periplasmic chaperones escort pilus subunits to the usher, a large protein comp

107 ded clusters of Shha-expressing epidermis to escort pObs into similarly split groups.

108 cific hetero-oligomeric complex (TIM10) that escorts polytopic proteins into the mitochondrial inner

109 ent the maximum entropy principle, one using escort probabilities, the other not.

110 ere we show that this duality fixes a unique escort probability, which allows us to derive a complete

111 e Rab substrate only when it is bound to Rab escort protein (REP).

112 type II requires that they first bind to Rab escort protein (REP).

113 pendent on a Rab-binding protein, termed Rab escort protein (REP).

114 eranylgeranyl transferase (GGTase) and a Rab escort protein (REP).

115 tween newly synthesized Rab proteins and Rab escort protein (REP).

116 CHM encodes the ubiquitously expressed Rab escort protein 1 (REP1), which is responsible for prenyl

117 tions in the CHM gene, which encodes the Rab escort protein 1 (REP1).

118 hat hair cells and retinal cells require Rab escort protein 1 for survival.

119 f adeno-associated viral vector encoding Rab Escort Protein 1 is described as a part of gene therapy

120 human Choroideremia gene, which encodes Rab escort protein 1.

121 MRS6 encodes a Rab escort protein and effector of the TOR pathway that play

122 that the cross-linked complexes contain Rab escort protein and GDI-1.

123 ariety of Rab GTPases in the presence of Rab escort protein but, unlike Rab-GGT in yeast and mammals,

124 n studies showed that formation of chaperone-escort protein complexes inhibited mtHsp70 self-associat

125 -associated protein is a molecular chaperone/escort protein for LDL receptor-related protein, a membe

126 of the LDLR and the third domain of RAP, an escort protein for LDLR family members.

127 ated protein (RAP) is a recognized chaperone/escort protein for members of the low density lipoprotei

128 tor-associated protein (RAP) functions as an escort protein for receptors of the low-density lipoprot

129 We suggest that PRA1 acts as an escort protein for small GTPases by binding to the hydro

130 Thus, CRF-BP emerges as a GPCR escort protein increasing the understanding of GPCR traf

131 alytic activity seen for a 10-fold excess of escort protein over enzyme.

132 ized that CRF-BP binds to CRF2R, exerting an escort protein role.

133 Cholesterol acts by binding to the SREBP-escort protein Scap, thereby causing Scap to bind to anc

134 to the following two membrane proteins: the escort protein Scap, thus preventing proteolytic process

135 ge-activating protein) is a sterol-regulated escort protein that transports SREBPs from their site of

136 pose a model in which Rad23p functions as an escort protein to link the 26 S proteasome with proteins

137 es of the endosomal Toll-like receptor (TLR) escort protein UNC93B, endosomal TLR7, -9, and -13, and

138 IscU, a NifU-like Fe/S-escort protein, binds to and stimulates the ATPase activ

139 everely affected in the absence of the Hsp70 escort protein, Hep1.

140 An escort protein, Msi4p, was necessary for geranylgeranyla

141 e prenylation of Ypt1p in the presence of an escort protein, Msi4p.

142 cholesterol, which triggers SCAP, the SREBP escort protein, to bind to Insigs, which are ER retentio

143 neration resulting from mutations in the Rab escort protein-1 (REP1).

144 e disease that results from mutations in Rab Escort Protein-1 (REP1).

145 e sorting signal (MELADL) in Scap, the SREBP-escort protein.

146 g of the Sec23/24 complex to Scap, the SREBP escort protein.

147 certain non-Rab GTPases independently of Rab escort protein.

148 n of newly synthesized Rab proteins with Rab-escort-protein (REP), the choroideremia-gene-product tha

149 mutations in the CHM gene, which encodes Rab escort-protein-1 (REP-1).

150 Hsp70 escort proteins (Hep) have been implicated as essential

151 Rab escort proteins (REP) 1 and 2 are closely related mammal

152 Importin alpha proteins have been shown to escort proteins into the nucleus through interaction wit

153 ular chaperones (mtHsp70), but the role that escort proteins play in regulating mammalian chaperone f

154 hese findings provide evidence that metazoan escort proteins regulate the catalytic activity and solu

155 ed on NIH 3T3 cells, vectors displaying TVTM escort proteins significantly enhanced the transduction

156 consistent with the presence of one or more escort proteins.

157 to the cell surface is tightly regulated by escort proteins.

158 the single-stranded T-DNA is stripped of its escorting proteins, most likely converts to a double-str

159 Ms that are stably incorporated as envelope "escort" proteins into retroviral vectors and that, by fu

160 he CRISP family represents a group of "sperm escort" proteins, which bind to sperm at various steps i

161 context of Moloney murine leukemia envelope "escort" proteins.

162 L facilitates constant recycling of Rab14 by escorting Rab14 to the membrane.

163 RT-1st, KEYNOTE-590, ORIENT-15, KEYNOTE-181, ESCORT, RATIONALE-302, ATTRACTION-3, and ORIENT-2 were i

164 if Rad51 recombinase (Rad51), a factor that escorts replication forks, aids replication across UV le

165 molecule that may represent a mechanism for escorting retinaldehyde.

166 ral RNA, the Rev response element (RRE), and escorts RRE-containing RNAs from the nucleus.

167 ents: preliminary phosphorylation of RSK and escorting RSK to a membrane-associated complex, where ad

168 , supporting diverse domains such as medical escort services, learning analysis, fatigue detection, a

169 We report here new covalent polymer-escort siRNA constructs that address both of these const

170 These autotransfecting polymer-escort siRNAs are viable in RNAi and effective in knocki

171 ructural evidence for sulfate binding at the escort site suggests that the mechanism of sulfate activ

172 sulfate ion competing for bicarbonate at the escort site, preventing passage of bicarbonate from the

173 ng the dimerization interface of HICA is an "escort" site that represents an intermediate along the i

174 elf once, and the secreted inactive protease escorts specific receptors for lysosomal degradation.

175 SREBP cleavage-activating protein (SCAP) to escort SREBP from the endoplasmic reticulum (ER) to the

176 etaining it in the ER and preventing it from escorting SREBPs from ER to the site of proteolytic acti

177 vating protein (SCAP) and preventing it from escorting SREBPs to the Golgi apparatus where the SREBPs

178 l-regulated fashion, thus preventing it from escorting SREBPs to the Golgi.

179 etaining it in the ER and preventing it from escorting SREBPs to the site of proteolytic activation i

180 In sterol-depleted cells, SCAP escorts SREBPs from ER to Golgi for proteolytic processi

181 In sterol-depleted cells, SCAP escorts SREBPs from ER to Golgi, where SREBPs are cleave

182 When cholesterol levels are low, Scap escorts SREBPs from the ER to the Golgi, where the actio

183 rotein (SCAP), a sterol-sensing protein that escorts SREBPs.

184 It has been proposed that escort stem cells (ESCs), which directly contact GSCs, g

185 e not replenished by the regular division of escort stem cells as previously suggested.

186 These "escort stem cells" morphologically resemble testis cyst

187 gests mechanisms by which proteins like SspB escort substrates to AAA+ ATPases and enhance the specif

188 this study demonstrates that EVs capture and escort systemic LPS to the cytosol licensing inflammasom

189 quires that the bacterial T-complex actively escorts T-DNA into the host's nucleus.

190 Get3 is a targeting factor that efficiently escorts tail-anchored (TA) proteins to the ER.

191 s by either inducing autophagy activation or escorting TDP-43 aggregates targeted autophagosomes, sug

192 zes the adenosylation of cob(I)alamin and an escort that delivers the product, adenosylcobalamin (Ado

193 air pathway choice, 53BP1 functions as a DSB escort that guards against illegitimate and potentially

194 se that one function of Sim3 is to act as an escort that hands off CENP-A(Cnp1) to chromatin assembly

195 tions as a lipophilic accessory appendage to escort the dichlorodisalicylmethane pharmacophore to a l

196 ed the receptor-associated protein (RAP), to escort the newly synthesized receptor from the endoplasm

197 s prior to one hour of its activation, which escort the p53 transcriptional program.

198 s on the 60S, on which Cdc48 is recruited to escort the substrate for proteasomal degradation.

199 PRM ligand binding does not directly escort the transition of MASP from zymogen to active enz

200 rdinating the assembly of V0 subunits and in escorting the assembled V0 complex into ER-derived trans

201 from the ER, while COPI acts more distally, escorting the detached, accelerating tubular entity on i

202 we also uncovered a novel role of Gemin5 in escorting the truncated forms of U1 pre-snRNAs for prope

203 Surrogate light chain, which escorts the mu heavy chain to the cell surface, is a cri

204 rerouting of U snRNAs and their cytoplasmic escort, the survival motor neuron (SMN) complex, to proc

205 e specific targets at pre-designed sites and escort them from nanopores at suitable speeds, thereby g

206 ent-containing mRNAs in the nucleus and then escort them through the nuclear pore, providing protecti

207 extract them from 60S particles in order to escort them to the proteasome for degradation.

208 latory element-binding proteins (SREBPs) and escorts them from the endoplasmic reticulum (ER) to the

209 y to class I MHC molecules as a tetramer and escorts them to lysosomes, where they are degraded.

210 infancy to recruit newborn astrocytes that 'escort' them into adulthood, and that the impairment of

211 After escorting these receptors to the Golgi, RAP dissociates

212 these, good vision in fellow eye and lack of escort to the hospital were the major reasons.

213 dsDNA is escorted to and the 5' single-stranded DNA (ssDNA) away

214 preserve centromere identity, CENP-A must be escorted to centromeres by a CENP-A-specific chaperone f

215 ell, intestinal as well as others, copper is escorted to specific compartments by metallochaperones.

216 Extracellular flagellar components are escorted to the export gate by dedicated molecular chape

217 at mutant mic2 lacking the C-domain might be escorted to the micronemes by association with endogenou

218 subunits, each devoid of export signals, are escorted to the periplasm in a piggyback fashion by the

219 nked ubiquitin chains, can the substrates be escorted to the proteasome for degradation.

220 The resulting aminoacylated tRNAs are escorted to the ribosome where they enter protein synthe

221 in homeostasis, and how they are selectively escorted to the target membrane is not well understood.

222 The preproteins are escorted to Tom70/Tom71 by molecular chaperones Hsp70 an

223 We propose a two-subunit escort translocation mechanism that is strict enough to

224 Within these structures, polyP may, in turn, escort vacuolar Mn to a number of storage ligands, inclu

225 ng organometallic cofactor in mammals and is escorted via an intricate network of chaperones to a sin

226 vidually or in groups but without ultralight escort, we found evidence of long-term social learning,

227 Escorts were influenced by the total signal emanating fr

228 ng good vision in the fellow eye and lack of escort, were the major determinants of late presentation

229 entified chaperone protein that specifically escorts Wnt ligands for secretion.

230 cts not directly related to cellular stress, escorting would allow increased ER exit and trafficking