ライフサイエンスコーパス: essential

1 e, robust assays with consistent results are essential.

2 understanding atrophy across this region is essential.

3 autophagy supports tumor cell metabolism is essential.

4 iple distinct pathways for which SGs are not essential.

5 el specificity, making removal of excess dye essential.

6 Accurate disease monitoring is essential after transarterial chemoembolization (TACE) i

7 e essential amino acids, and a conditionally essential amino acid and its precursor.

8 L-Tryptophan is an essential amino acid required for protein synthesis.

9 such as pyridoxine/vitamin B6, taurine, some essential amino acids, and a conditionally essential ami

10 the biogenesis of lipid A, the conserved and essential anchor of LPS.

11 find that influential genes are enriched in essential and cancer genes.

12 ergy and emission pathways for meeting three essential and energy-intensive dimensions of basic well-

13 Furthermore, aimB appears to be essential, and its depletion results in decreased cell w

14 e of the inhibitory neurotransmitter GABA is essential, and reuptake failure worsens human seizures.

15 is rescued by isopentenyl pyrophosphate, an essential apicoplast product, confirming an apicoplast-s

16 An essential aspect of fast activation is the processing of

17 d of invasive alien species (IAS) are now an essential aspect of IAS management.

18 Deletion of essential autophagy genes increased the sensitivity of m

19 e mammary cancer models to temporally delete essential autophagy regulators during carcinoma progress

20 The plant is a useful source of essential bioactive compounds such as steroids, flavonoi

21 ecognition of carbohydrates is a key step in essential biological processes.

22 Oxygen defects are essential building blocks for designing functional oxide

23 h potentials were generally thought to be an essential but homeostatic contributor to complex bacteri

24 Recanalization of the occluded vessel is essential but not sufficient to guarantee brain salvage.

25 lucidated structural components that underly essential cell cycle processes, and influenced our think

26 a required micronutrient for bacteria and an essential cofactor for redox-active cuproenzymes.

27 small molecule dicarboxylate that acts as an essential cofactor in this process and works in synergy

28 Vitamin B(12) and other cobamides are essential cofactors required by many organisms and are s

29 regarding the afferent synapse, which is an essential component in the faithful temporal transmissio

30 Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved

31 Cholesterol is an essential component of mammalian cell membranes, constit

32 Despite being an essential component of meta-analyses, heterogeneity was

33 MMS21 encodes a SUMO E3 ligase and an essential component of the Smc5/6 complex, involved in s

34 Specifically, we identify LRRC8A, an essential component of volume-regulated anion channels (

35 Several essential conditions for in vitro transcription by T7 RN

36 Interleukin 15 (IL-15) is an essential cytokine for the survival and proliferation of

37 Thus, TRIM37 is an essential determinant of mitotic vulnerability to PLK4 i

38 Pre-B cell leukemia factor 1 (PBX1) is an essential developmental transcription factor, mutations

39 Vitamin B(1) is an essential dietary component, and deficiencies in this mi

40 how pharmacologically diverse and clinically essential drugs act through overlapping and distinct mec

41 These results suggest that DGK2 and DGK4 are essential during gametogenesis and are required for ER-l

42 MLKL is the essential effector of necroptosis, a form of programmed

43 eakage of retinal blood vessels, which is an essential element of diabetic retinopathy, is driven by

44 studies and structural comparisons identify essential elements of both the allosteric ligands and re

45 We confirm the essential elements of the previous experimental observat

46 aryotic translation initiation factor 2B, an essential enzyme in the initiation of protein synthesis,

47 nymous codon substitutions encoding a single essential enzyme lead to dramatically slower cell growth

48 s in humans, we propose C15:0 as a potential essential fatty acid.

49 terms of targeted signaling pathways is the essential first step in evaluating their therapeutic pot

50 red in the selection tree, an aspect that is essential for a quantitative method's robustness but sel

51 Centromeres are essential for accurate chromosome segregation and are ma

52 The template-based approach has been essential for achieving high-quality models in the recen

53 a major eukaryotic ssDNA-binding protein, is essential for all metabolic processes that involve ssDNA

54 Further, although female blood-feeding is essential for anautogenous mosquito reproduction, the tr

55 Memory stability is essential for animal survival when environment and behav

56 he organization of septin GTPases, which are essential for appressorium-mediated infection in the ric

57 e subunits including the subunit H, which is essential for ATPase activity.

58 We report here that DksA is essential for B. burgdorferi to infect a mammalian host.

59 egative bacteria is a multilayered structure essential for bacterial viability; the peptidoglycan cel

60 Sulfur is essential for biological processes such as amino acid bi

61 leotide exchange activity of DOCK5, which is essential for bone resorption by osteoclasts.

62 ary placode or descending mammary bud, it is essential for both the prenatal hormone-independent as w

63 ndicating that endogenous synthesis of LA is essential for C. elegans development.

64 1 and MICU2, and an auxiliary subunit, EMRE, essential for Ca(2+) transport(3-8).

65 unit complex that folds many of the proteins essential for cancer development.

66 tive results led to MELK being classified as essential for cancer proliferation.

67 recruited to the injured myocardium and are essential for cardiac repair as they can adopt both pro-

68 er concentrations of intracellular metals is essential for cell fitness and pathogenesis.

69 ndrial morphology and activity regulation is essential for cell survival, differentiation, and migrat

70 hile some metals such as iron and copper are essential for cellular functions, others such as cadmium

71 n volume is a fundamental property of cells, essential for cellular integrity in the face of osmotic

72 Phagocytes are essential for clearance of CDC-producing bacteria; howev

73 plexes and that the subpellicular complex is essential for cytokinesis and viability of disease-causi

74 Low molecular weight metabolites are essential for defining the molecular phenotypes of cells

75 s, select autophagy genes, but not all genes essential for degradative autophagy, have a key function

76 nding of disease seasonal synchronization is essential for developing reliable outbreak forecasts and

77 Efficient S phase entry is essential for development, tissue repair, and immune def

78 die prior to E8.5, indicating that Wbp11 is essential for development.

79 to express genes ectopically in bacteria is essential for diverse academic and industrial applicatio

80 ples substrate specificity to an ATPase step essential for DNA methylation.

81 ature is the AT-rich -10 element; a sequence essential for DNA unwinding.

82 these extracellular disulfide bonds and are essential for ECM degradation.

83 abolite trehalose 6-phosphate (Tre6P) and is essential for embryogenesis and normal postembryonic gro

84 ns via piRNA-mediated gene silencing that is essential for embryonic development.

85 rating that for ABCG2 a single amino acid is essential for engaging and initiating transport of multi

86 formation between homologous chromosomes is essential for faithful segregation.

87 nication by retrograde signaling pathways is essential for fine-tuning of responses to the prevailing

88 ls that have such rings, they are not always essential for furrow formation.

89 hosphate pathway of isoprenoid synthesis, is essential for Gram-negative bacteria, mycobacteria and a

90 ow that the full-length C terminus of p73 is essential for hippocampal development.

91 es demonstrate remarkable plasticity that is essential for host defense and tissue repair.

92 Monocytes are innate immune cells essential for host protection against malaria.

93 we demonstrate that MDA5/MAVS signaling was essential for host resistance against pulmonary Aspergil

94 ent and tissue-specific imprinting, which is essential for infection and autoimmunity.

95 ng and decentering of cellular components is essential for internal organization of cells and their a

96 uman kidneys with NEP rather than ACE2 being essential for its generation.

97 Robust serological assays are essential for long-term control of the COVID-19 pandemic

98 (CREB) to enhance the expression of proteins essential for long-term synaptic plasticity and memory.

99 Our results show that TrkC is essential for maintaining glomerular integrity.

100 gametes (gametogenesis) within mosquitos is essential for malaria parasite transmission.

101 rom within membrane necks, a process that is essential for many cellular functions, from cell divisio

102 better understanding of these cells would be essential for meaningful and lasting treatments.

103 t the cooperative function of EBE and TIE is essential for mediating AF-1-dependent transactivation.

104 s known, the desmosome architecture-which is essential for mediating numerous functions-remains elusi

105 NP-A marks centromeres epigenetically and is essential for mitotic fidelity.

106 onstrate that the autocrine FGF/FGFR axis is essential for multiple myeloma cell survival and progres

107 iated interactions between proteins that are essential for multiple phases of the viral replication c

108 pper-exporter upregulated by mutant KRAS, is essential for neoplastic growth.

109 dtii, the LHCSR pigment-binding proteins are essential for NPQ.

110 , but also revealed that phosphorylation was essential for OPN secretion.

111 14), and outer membrane protein A (OmpA) are essential for optimal bacterial entry into host cells, b

112 in the mesoderm layer of the early embryo is essential for organization of the body plan.

113 kinesin-1, and an actin motor, myosin-V, are essential for osk mRNA posterior localization.

114 ng cancer patients before tumor resection is essential for patient selection for surgery and is conve

115 led to the common opinion that carotenes are essential for photosynthesis.

116 respiratory responses to O(2) deficiency are essential for physiological homeostasis.

117 is not required for piRNA biogenesis but is essential for piRNA-directed TE de novo methylation and

118 family kinases (SFKs) Src, Lyn, and Fyn are essential for platelet activation and also involved in m

119 ructures are ubiquitous on eukaryotic mRNAs, essential for post-transcriptional processing, translati

120 The enhancer cluster was essential for prenatal and postnatal ventricular express

121 Our results demonstrate that EWSR1 is essential for promoting PRDM9-dependent histone methylat

122 n mediates chromosome condensation, which is essential for proper chromosome segregation during mitos

123 rect evidence that the nectin-afadin axis is essential for proper palate shelf elevation and fusion.

124 e engagement of CAs in some brain regions is essential for providing the brain with the resilience ne

125 Electronic skins are essential for real-time health monitoring and tactile pe

126 Lys 4 (H3K4) methylation and its members are essential for regulating gene expression.

127 Thus, our findings define a mechanism essential for replisome assembly during DNA replication

128 or (CTCF), a crucial chromatin organizer, is essential for Schwann cell myelination and myelin regene

129 Aggression is a social behavior essential for securing resources and defending oneself a

130 , conserved macromolecular machines that are essential for soluble N-ethylmaleimide-sensitive factor

131 ge and spin currents via spin-Hall effect is essential for spintronics.

132 mative, and functional molecular markers are essential for studying a wide range of genetic parameter

133 Because B vitamins are essential for survival, null mutations often have embryo

134 anoctamin 1 (ANO1) was tested since each is essential for SW and tone generation.

135 rotransmitter receptor trafficking, which is essential for synaptic plasticity.

136 of highly reactive nitroso intermediates is essential for target inactivation in vivo.

137 nd distribution of asymptomatic infection is essential for targeted interventions.

138 o maturing erythroid precursors (EPs) and is essential for terminal erythropoiesis.

139 LuxS is essential for the activated methyl cycle and generates h

140 ences (CNSs) were also determined, which are essential for the activity of the promoter.

141 The assembly of this catalytic centre is essential for the addition of ADP-ribose moieties after

142 nt, demonstrating that fast fluctuations are essential for the allosteric control of PTP1B activity.

143 the synergy of H(2)O(2) and gluconic acid is essential for the antibacterial activity of honey.

144 ocus on the behaviorally relevant signals is essential for the brain to cope with the continuous, hig

145 The maintenance of genome stability is essential for the cell as the integrity of genomic infor

146 ntation, and the linkage of her1 and her7 is essential for the development of the body axis in zebraf

147 monstrate that Fatty Acid Oxidation (FAO) is essential for the differentiation of blood cell progenit

148 e pattern of motor neuron (MN) activation is essential for the execution of motor actions; however, t

149 NAC-induced regulations of SRP activity are essential for the fidelity of cotranslational protein ta

150 demonstrate a requirement for Kif3a, a gene essential for the formation of primary cilia, in a mouse

151 Omega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the brain.

152 Together, these results show that CsrA is essential for the growth of A. baumannii on host-derived

153 pression on CDK11 could explain why CDK11 is essential for the growth of many cancers.

154 Basal autophagy in kidney cells is essential for the maintenance of kidney homeostasis, str

155 priate control of hepatic gluconeogenesis is essential for the organismal survival upon prolonged fas

156 tate detection of small-amplitude vibrations essential for the perception of fine-grained tactile sur

157 S) is a multisubunit protein complex that is essential for the proper architecture of the mitochondri

158 g a local H3K9 trimethylation signal that is essential for the proper execution of HDR.

159 recombinant spidroins, but are thought to be essential for the spiders' natural spinning process.

160 vessels after myocardial infarction (MI) is essential for the survival of existing and regenerated c

161 ght transcription factors, each of which was essential for the transition from primordial to primary

162 tly discovered van der Waals ferromagnets is essential for their integration in future spintronics de

163 the LJBSF is a highly organized subfield are essential for understanding its possible role in cortica

164 ates the development of the root meristem is essential for understanding stem cell function.

165 allmark of biological visual systems, may be essential for understanding the accuracy, flexibility, a

166 ovo initiation and elongation activities and essential for viral replication.

167 ibitors of norovirus 3CL protease, an enzyme essential for viral replication.

168 y ignoring a distractor stimulus and provide essential foundations for further revealing the neural m

169 pids are basic cellular constituents playing essential functions in energy storage and the cellular s

170 t the double tag does not interfere with the essential functions of RanBP9.

171 rvoir of genes for identifying mycobacterial essential functions, identifying potential drug targets

172 ortant to allow adaptation while maintaining essential functions.

173 can conditionally delete Stk11 and autophagy essential gene, Atg7, respectively or simultaneously, th

174 Furthermore, essential genes for the cell development and embryogenes

175 uencing has been employed to define the core essential genome of this bacterium and genes conditional

176 bstituted backbone heteroatoms is one of the essential goals that must be achieved in order to contro

177 l in vivo Consequently, B. fragilis acquires essential heme from host tissues during extraintestinal

178 m, and therapeutic target, for aging-induced essential hypertension in humans.

179 Synaptogenesis is essential in forming new neurocircuits during developmen

180 me of this bacterium and genes conditionally essential in multiple environments - abscess formation;

181 d viruses that coexist in our bodies and are essential in protective, metabolic, and physiologic func

182 nstrated that Toll-like receptor 7 (TLR7) is essential in the induction of anti-RABV antibodies via t

183 d for translocon insertase apparatus that is essential in vivo.

184 their variable circulation patterns provide essential information for future surveillance, diagnosis

185 nd bacteria in the human intestine, which is essential information for the development of phage thera

186 ersection between metal starvation and other essential inorganic nutrients has not been investigated.

187 ate that the full capsid is required for the essential interaction with its GAG receptor(s).

188 plore drivers of behavioural phenotypes, the essential investigations for phylogenetic constructs of

189 Although LeuRS-I was not essential, its expression clearly supported optimal S. i

190 obial interactions in the rhizosphere are an essential link in soil nitrogen (N) cycling and plant N

191 nsitions and domain motions displayed by the essential mannosyltransferase PimA from mycobacteria.

192 Mdn1 is an essential mechanoenzyme that uses the energy from ATP hy

193 RAC1, a Rho family GTPase, is an essential mediator of HDAC6 function, and is necessary a

194 yeast Ty3/Gypsy co-opts binding sites of the essential meiotic transcription factor Ndt80 upstream of

195 NAD(+) is an essential metabolite participating in cellular biochemic

196 g exquisite fine-tuning of delivery of these essential metabolites.

197 oach to screen for phenotypic targets of the essential mir-35-42 family.

198 We also learned that FMO3 is an essential modifier of the polyketide.

199 namide phosphoribosyltransferase (NAMPT), an essential NAD(+) biosynthetic enzyme in skeletal muscle,

200 ked nonvascular disruption in T1D of several essential neural nodes engaged in both cognitive and mot

201 ly dense rotational spectra observed, it was essential not only to locate several hundred homo/hetero

202 Inorganic orthophosphate (Pi) is an essential nutrient for plant growth, and its availabilit

203 80) micelles loaded with plant-based oregano essential oil (OR) and trans-cinnamaldehyde (TCA) was st

204 Overall, essential oil components as well as antioxidants showed

205 0% and 25% WA) on antioxidant attributes and essential oil constituents of Hyssopus officinalis L. in

206 Oregano essential oil has long been known for its health-promoti

207 enzenes (eugenol and seven analogues) in the essential oils, a broadly distributed class of natural f

208 Changes in coordination between these two essential organelles are associated with metabolic disor

209 environmental factor, we compared a range of essential parameters for an oxidation reaction on platin

210 The oral cavity, an essential part of the upper aerodigestive tract, is beli

211 e of conducting rounds at patients' bedside; essential participants in rounds; the inclusion of ICU p

212 f U as a function of the presence of various essential plant nutrients contained in these minerals re

213 Reversible protein phosphorylation is an essential post-translational modification regulating pro

214 partly due to parameterization, which is an essential procedure for model specification via defining

215 annotation of short-reads metagenomes is an essential process to understand the functional potential

216 These essential processes enhance fluidity of blood, although

217 Identified mutations were enriched in essential protein domains and genes identified by NIPPER

218 An essential protein of the SARS-CoV-2 virus, the envelope

219 e structural and functional insights into an essential protein that is required for organelle-specifi

220 he enzyme N-myristoyltransferase (NMT) is an essential protein, which catalyzes the myristoylation of

221 trials have shown similar mortality, but the essential question is whether the sensitivity and specif

222 ere we identify alphaV-integrin (CD51) as an essential regulator of cardiac PW1(+) cells fibrogenic b

223 Here, we identified c-Maf as an essential regulator of ILC3 homeostasis and plasticity t

224 ctively, we show that MADS78 and MADS 79 are essential regulators of early seed developmental transit

225 l adhesion molecules (dscam and dscaml1) are essential regulators of neural circuit assembly, but the

226 h an RNAi screen, we identified FBXO44 as an essential repressor of REs in cancer cells.

227 The RNA exosome is an essential ribonuclease complex required for processing a

228 However, whether SNr deactivation has an essential role driving or regulating active avoidance re

229 g capability of the auditory system-plays an essential role in animals' survival (e.g., detect devian

230 Nanomaterials can play an essential role in bacterial sensing owing to their uniqu

231 ectively, our data show that Sema3E plays an essential role in dampening the early inflammatory respo

232 nsport from the ERGIC, as demonstrated by an essential role in forming the replication vacuole of Leg

233 de that, in early plants, H3K27me3 played an essential role in heterochromatin function, suggesting a

234 es for gene regulation in plants and play an essential role in plant-pathogen interactions.

235 er that belongs to SLC30 family and plays an essential role in regulating Zn(2+) accumulation in the

236 relay it to other brain regions, serving an essential role in sensory perception and motor execution

237 Irrigation plays an essential role in sustaining crop production in water-li

238 us is a primary lymphoid organ that plays an essential role in T lymphocyte maturation and selection

239 ession in the cochlea and highlights MYO7A's essential role in tensioning the hair cell MET complex.

240 irculating cytokine that is known to play an essential role in the endothelial homeostasis and the bi

241 t here that the bacterial sRNA SsrA plays an essential role in the light-organ symbiosis between Vibr

242 e complexity of the species indicating their essential role in the maintenance of regulatory networks

243 lites have gained attention because of their essential role in the pathogenesis and progression of ki

244 ulin/IGF-1 signalling (IIS) pathway plays an essential role in the regulation of glucose and lipid ho

245 all nuclear ribonucleoprotein (snRNP) has an essential role in the selection of the precursor mRNA br

246 engagement with human ACE2 receptor plays an essential role in viral entry into host cells.

247 egulating macrophage function, suggesting an essential role of this pathway in macrophage inflammator

248 Our work uncovers an essential role of YTHDF3 in controlling the interaction

249 dent cell-cell adhesion proteins, which play essential roles in animal evolution, tissue development,

250 Although APE2 plays essential roles in base excision repair and ATR-Chk1 DNA

251 Plastid isoprenoid-derived carotenoids serve essential roles in chloroplast development and photosynt

252 creases in NNT, a mitochondrial protein with essential roles in influencing levels of NADH and NADPH,

253 Microtubules are tubular polymers with essential roles in numerous cellular activities.

254 conserved, multi-protein/RNA complexes with essential roles in processing ribosomal and tRNAs.

255 ECM (extracellular matrix) interactions play essential roles in the morphogenesis of PAAs and their d

256 Interlayer coupling plays essential roles in the quantum transport, polaritonic, a

257 and an actomyosin ring-and also defines the essential roles of a RhoGEF-anillin module in septin arc

258 ANKS4B is known to be an essential scaffold within the IMAC, although its functio

259 ium dependent protein kinase 1 (CDPK1) is an essential Ser/Thr kinase that controls invasion and egre

260 reactive oxygen species (ROS) that mediates essential signaling in vivo but may cause irreversible t

261 severely stunted in growth due to removal of essential soluble nutrients - particularly, nitrogen, ph

262 xylase), decarboxylation is not a completely essential step in its catalysis.

263 d data into genomic surveillance systems, an essential step toward a more comprehensive understanding

264 amerization of the viral capsid and provided essential structural and functional knowledge for ration

265 Phosphatidylinositol (PI) is an essential structural component of eukaryotic membranes t

266 es of rapid change to adapt while supporting essential structures of society.

267 ak must strike a balance between maintaining essential supply chains and limiting the spread of the v

268 not result from an interaction with a single essential target but rather from the multilevel control

269 irreproducibility is to be eliminated, it is essential that scientists engaged in pre-clinical resear

270 hile these CSLD polysaccharide synthases are essential, the nature of the polysaccharides they synthe

271 and machine behavior, and that it should be essential to any such comparison.

272 osuppressive properties of human gliomas are essential to assess immune-based therapies.

273 considering the soft nature of the gel it is essential to be well analyzed.

274 hus, the function lost by these mutations is essential to cell survival.

275 learn, teach, and innovate - three processes essential to cumulative technological culture (CTC).

276 biomarker and neuropathological studies are essential to determine the underlying pathobiological me

277 ectrical properties of biological neurons is essential to determine their complement of ion channels

278 g other methods than by candidate genes, are essential to developing methods that may predict the pro

279 n of noncognate TCs on a sub-ms timescale is essential to enable incorporation of the rare cognate am

280 in agricultural systems, P fertilisation is essential to feed the world.

281 .SIGNIFICANCE STATEMENT Brain tissue iron is essential to healthy brain function.

282 Therefore, it is essential to identify early-stage biomarkers in those at

283 ecision and molecularly defined structure is essential to interface electronics and advance their qua

284 lectrode degradation, which is fundamentally essential to make M-N-C catalysts viable in PEMFC techno

285 Multivalent binding is essential to many biological processes because it builds

286 isruption of CD133 signal to PI3K pathway is essential to overcome Melanoma resistance to fotemustine

287 Although this process of myotube guidance is essential to pattern the musculoskeletal system, the mec

288 fungus Candida albicans IL-17R signaling is essential to prevent OPC in mice and humans, but the ind

289 ment, but it also mediates DNA damage repair essential to proliferating neural progenitor cells (NPCs

290 l death and inflammatory immune responses is essential to promote protection against coronavirus infe

291 d that biquadratic exchange interactions are essential to quantitatively describe the magnetism of Cr

292 Therefore, it is essential to recognize the disease process at the earlie

293 valuations of nanotechnology-based drugs are essential to support initiation of clinical trials.

294 that disrupt cell wall biogenesis, a process essential to the survival of bacteria.

295 ring inflorescence and floral development is essential to understand their role in the evolutionary o

296 (TAM) inducible Cre recombinase system is an essential tool to study gene function when early ablatio

297 The aim of this research was to quantify essential trace elements (iron, copper, zinc and iodine)

298 30% of the daily dietary reference intake of essential trace minerals like Cr or Mo.

299 Carbon-carbon bond forming reactions are essential transformations in natural product biosynthesi

300 e adaptor ACT1 leading to the release of the essential ubiquitin ligase TRAF6 from the complex.