ライフサイエンスコーパス: essential tremor

1 essful sites of deep brain stimulation (DBS; essential tremor).

2 (4 mm anterior and 3 mm superior to that for essential tremor).

3 c acid tone seems to be a central feature of essential tremor.

4 ing an important role in the pathogenesis of essential tremor.

5 in stimulation pulses are delivered to treat essential tremor.

6 n of the thalamus can help ameliorate severe essential tremor.

7 s in the Purkinje cell axonal compartment in essential tremor.

8 h clinical diagnostic error rates for PD and essential tremor.

9 patients with severe, medication-refractory essential tremor.

10 ges and cell death deserves further study in essential tremor.

11 ultrasound thalamotomy for the treatment of essential tremor.

12 s: Parkinson's disease, primary dystonia and essential tremor.

13 tructural abnormalities in the brain such as essential tremor.

14 ceptor antagonist, can trigger or exacerbate essential tremor.

15 and potential targets for pharmacotherapy of essential tremor.

16 nt findings of mild olfactory dysfunction in essential tremor.

17 innervation, as did the member with isolated essential tremor.

18 most common causes are Parkinson disease and essential tremor.

19 the primary motor cortex in individuals with essential tremor.

20 thmic motor drive responsible for generating essential tremor.

21 suffer from postural tremor, consistent with essential tremor.

22 include Lewy body dementia and some forms of essential tremor.

23 ng tremor, but not in Parkinson's disease or essential tremor.

24 were significantly improved in patients with essential tremor.

25 disorders, including Parkinson's disease and essential tremor.

26 their patterns and diagnose diseases such as essential tremor.

27 cted from control subjects and patients with essential tremor.

28 olivocerebellum determines the frequency of essential tremor.

29 eep brain stimulation for some patients with essential tremor.

30 short-term memory system in the diagnosis of essential tremor.

31 ffective treatment for medication refractory essential tremor.

32 effective treatment for medically refractory essential tremor.

33 inform targeting and programming in DBS for essential tremor.

34 dementia, Parkinson's disease, and probable essential tremor.

35 nt disorders such as Parkinson's disease and Essential Tremor.

36 with tremor improvement in both dystonic and essential tremor.

37 ndent stimulation of the cerebellum to treat essential tremor.

38 r-cognitive interactions in individuals with essential tremor.

39 patient-specific therapeutic approaches for essential tremor.

40 years) who underwent DBS in the treatment of essential tremor.

41 disorders, including Parkinson's disease and essential tremor.

42 erapeutic modality that can be used to treat essential tremor.

43 ase and the ventral intermediate nucleus for essential tremor.

44 ctivity in patients with dystonic tremor and essential tremor.

45 overdiagnosis of well-known causes, such as essential tremor.

46 reatest alpha desynchronization occurring in essential tremor.

47 history studies show a high heritability for essential tremor.

48 al coactivator PPARGC1A were associated with essential tremor.

49 LINGO1) did not confirm the association with essential tremor.

50 safety and efficacy of DBS in patients with essential tremor.

51 ould be of importance in the pathogenesis of essential tremor.

52 s with the degree of clinical improvement in essential tremor.

53 ring stereotactic surgery for the control of essential tremor (70 patients).

54 Among 188 with essential tremor, 90 (47.9%) had rest tremor; 75.6% with

55 Clinical diagnoses were essential tremor (93.5%), essential tremor with possible

56 conducted a genome-wide association study of essential tremor, a common movement disorder characteriz

57 on's disease, obsessive-compulsive disorder, essential tremor, addiction, pain, minimally conscious s

58 m, one clinically normal and one with benign essential tremor alone.

59 phere, as the primary generator of tremor in essential tremor, also with a significant contribution o

60 nucleus of the thalamus in 29 patients with essential tremor and 24 patients with Parkinson's diseas

61 erebellar cortical tissue from 27 cases with essential tremor and 27 age-matched control subjects was

62 f the Purkinje cell axonal compartment in 49 essential tremor and 39 control brains, using calbindin

63 ebellar syndrome (multiple sclerosis, n = 3; essential tremor and ataxia, n = 1), although clinical t

64 is a standard of care in Parkinson disease, essential tremor and dystonia, and is also under active

65 tudy explored the optimal targets for DBS in essential tremor and dystonic tremor using a combination

66 h Parkinson's disease, in four subjects with essential tremor and in none of the subjects with psycho

67 ations for understanding the pathogenesis of essential tremor and its relationship to Parkinson disea

68 Rest tremor can be present in advanced essential tremor and may be a harbinger of conversion.

69 This review will consider Parkinson disease, essential tremor and other tremors and highlight advance

70 en Food and Drug Administration-approved for essential tremor and Parkinson disease and has a humanit

71 Common tremors like essential tremor and Parkinson disease tremor can be rec

72 based management of the most common tremors, essential tremor and Parkinson disease tremor.

73 ion consanguineous Turkish kindred with both essential tremor and Parkinson disease, we carried out w

74 lso showed good efficacy in rodent models of essential tremor and Parkinson's disease.

75 cal therapy for movement disorders including essential tremor and Parkinson's disease.

76 phy to discriminate Parkinson's disease from essential tremor and Parkinsonism, the involvement of no

77 ures of dystonic tremor can resemble that of essential tremor and present a diagnostic confound for c

78 rentiating parkinsonian syndromes (PS), from essential tremor and probable dementia with Lewy bodies

79 rs substantially between dystonic tremor and essential tremor and should be further explored in imple

80 Accordingly, we stimulated 10 patients with essential tremor and thalamic electrodes, while recordin

81 HTRA2 p.G399S is responsible for hereditary essential tremor and that homozygotes for this allele de

82 Pharmacologic treatment for essential tremor and the tremor of Parkinson's disease i

83 It is currently FDA approved for essential tremor and tremor dominant Parkinson's disease

84 roup of male and female subjects affected by essential tremor and undergoing deep brain stimulation s

85 ibrillation, occlusion of cerebral arteries, essential tremor, and abnormal reflexes were not signifi

86 the tapping limb in Parkinson's disease and essential tremor, and its frequency in many cases shifte

87 nts than Parkinson's disease rest tremor and essential tremor, and its frequency was less consistent.

88 uggest an association between blood lead and essential tremor, and that this association is modified

89 disease and 20 postural tremor recordings in essential tremor, and validated on a second, independent

90 neuronal and EMG activities during intention essential tremor are similar to those of the intention t

91 orrelates of clinical heterogeneity in human essential tremor are unknown.

92 The molecular genetic determinants of essential tremor are unknown.

93 n the efficacy of neurosurgical treatment of essential tremor, are in contrast to those of previous s

94 siology of other movement disorders, such as essential tremor, are relatively unexplored.

95 Here, I show that observations on essential tremor arising from clinical practice/clinical

96 ern regarding the potential risks of certain essential tremors associated with the long-term, low-lev

97 Two hundred one essential tremor brains in the Essential Tremor Centrali

98 a safe and effective therapy for refractory essential tremor, but information regarding long-term ou

99 y of focused ultrasound (FUS) thalamotomy in essential tremor, but its effectiveness and safety for m

100 atterns of dopamine and serotonin release in essential tremor, but not Parkinson's disease, patients.

101 erves, have also been developed for treating essential tremor, but the clinical outcomes remain incon

102 nificant tremor suppression in patients with essential tremor, but with significant inter-patient var

103 otor cortex were made from six patients with essential tremor by magnetoencephalography.

104 t that subjects with Parkinson's disease and essential tremor can produce movements that are kinemati

105 , the dendritic spine density was reduced in essential tremor cases (medians=0.82 versus 1.02 microm(

106 climbing fibre-Purkinje cell synapses of 12 essential tremor cases and 13 age-matched controls from

107 apses using post-mortem cerebellar tissue of essential tremor cases and controls.

108 In all measures, essential tremor cases demonstrated significant reductio

109 We observed that, compared with controls, essential tremor cases had decreased climbing fibre-Purk

110 orpedoes) are present to a greater degree in essential tremor cases than controls.

111 apparent in the Purkinje cell population in essential tremor cases versus age-matched controls.

112 Median values in essential tremor cases versus controls were: 5712.1 vers

113 ] were all present to an increased degree in essential tremor cases versus controls.

114 d were correlated with tremor duration among essential tremor cases with age of onset >40 years.

115 In essential tremor cases, thickened axonal profiles, axona

116 o hundred one essential tremor brains in the Essential Tremor Centralized Brain Repository underwent

117 We examined autopsy tissue from the Essential Tremor Centralized Brain Repository.

118 n Purkinje cells have been identified in the essential tremor cerebellum, although the mechanisms tha

119 logical differences between parkinsonian and essential tremor circuits.

120 nal trajectory of cognitive impairment in an essential tremor cohort yet presented.

121 mild cognitive impairment and dementia in an essential tremor cohort.

122 g the grip-force task in dystonic tremor and essential tremor cohorts.

123 ng with a matched cohort of 20 patients with essential tremor DBS.

124 ith medication-refractory dystonic tremor or essential tremor, deep brain stimulation (DBS) targeting

125 remor suppression) in selected patients with essential tremor despite delivering less than half the e

126 Some but not all persons with essential tremor develop signs of Parkinson disease, and

127 tor incoordination that is characteristic of essential tremor disease.

128 it mechanism that may underlie the prevalent essential tremor disorder.

129 mon hyperkinetic movement disorders, namely, essential tremor, dystonia, Huntington disease and other

130 for conditions such as Parkinson's disease, essential tremor, dystonia, obsessive-compulsive disorde

131 ts and task prioritization in 15 people with Essential Tremor (ET) and 15 age-matched people without

132 ulation surgery, compared with patients with essential tremor (ET) and isolated dystonia (ID).

133 d ultrasound (MRgFUS) thalamotomy lesions in essential tremor (ET) and tremor-dominant Parkinson dise

134 ical disorders, neuropathological studies of essential tremor (ET) are rare.

135 Parkinson's disease (PD) and essential tremor (ET) are the two most common movement d

136 undergoing deep brain stimulation (DBS) for essential tremor (ET) from 5 different European centers

137 Thalamomuscular coherence in essential tremor (ET) has consistently been detected in

138 Essential tremor (ET) is a common condition that is pres

139 Essential tremor (ET) is a common movement disorder with

140 Essential tremor (ET) is among the most misdiagnosed neu

141 Essential tremor (ET) is among the most prevalent moveme

142 Essential tremor (ET) is one of the most common movement

143 Essential tremor (ET) is one of the most common movement

144 Essential tremor (ET) is one of the most common neurolog

145 Essential tremor (ET) is one of the most common neurolog

146 Essential tremor (ET) is one of the most prevalent movem

147 Essential tremor (ET) is the most common tremor disorder

148 Essential tremor (ET) is the most prevalent adult-onset

149 Essential tremor (ET) is the most prevalent movement dis

150 Essential tremor (ET) is the most prevalent movement dis

151 Materials and Methods Participants with essential tremor (ET) or Parkinson disease (PD) undergoi

152 cted from DBS surgical instruments in PD and essential tremor (ET) patients and demonstrate that alph

153 We screened 662 subjects comprising 462 essential tremor (ET) subjects (285 sporadic, 125 with f

154 e aberrant neural oscillation that hallmarks essential tremor (ET) syndrome, the most common adult mo

155 ese patients with that seen in patients with essential tremor (ET) using two neurophysiological techn

156 tures, which show selective vulnerability in essential tremor (ET), a cerebellar degenerative disorde

157 Essential tremor (ET), a movement disorder characterised

158 Essential tremor (ET), a movement disorder characterized

159 The causative genes for essential tremor (ET), one of the most common genetic ne

160 In addition to redefining essential tremor (ET), the 2018 consensus statement of t

161 Essential tremor (ET), the cause of which remains poorly

162 The pathophysiology of essential tremor (ET), the most common movement disorder

163 mmon symptom of Parkinson's disease (PD) and essential tremor (ET), which affects manual targeting, m

164 own to be a safe and effective treatment for essential tremor (ET).

165 disorders, including Parkinson's disease and essential tremor (ET).

166 a, a cardinal sign of ataxia, from tremor in essential tremor (ET).

167 cted white matter microstructural changes in essential tremor (ET).

168 n to have efficacy in treating patients with essential tremor (ET).

169 f patients with Parkinson's disease (PD) and Essential Tremor (ET).

170 rders including Parkinson's Disease (PD) and Essential Tremor (ET).

171 lence of and conversion rates to dementia in essential tremor fall between those associated with the

172 recent attention to cognitive impairment in essential tremor, few studies examine rates of conversio

173 safe and effective therapy in patients with essential tremor followed for up to 13 years.

174 Patients treated with DBS for essential tremor for at least 8 years were evaluated in

175 connectivity networks in dystonic tremor and essential tremor groups relative to controls.

176 ced by low frequency thalamic stimulation in essential tremor has a narrower frequency-amplitude tole

177 termedius nucleus deep brain stimulation for essential tremor has been the loss of surgical efficacy

178 g disorders, such as Parkinson's disease and essential tremor, has encouraged its application to a wi

179 Surgical therapies are effective in reducing essential tremor, however, the invasive nature of these

180 In this pilot study, essential tremor improved in 15 patients treated with MR

181 rformance for Parkinson's disease tremor and essential tremor, in both test and validation datasets.

182 Essential tremor is a common brain disorder affecting mi

183 Essential tremor is a common neurological disorder, char

184 Prospective studies demonstrated that essential tremor is a risk factor for Parkinson's diseas

185 Development of dementia in essential tremor is associated with loss of functional a

186 rders including Parkinson's disease (PD) and essential tremor is determined through clinical assessme

187 Essential tremor is one of the most common movement diso

188 Essential tremor is one of the most frequent movement di

189 our data suggest that the pathophysiology of essential tremor is primarily attributable to the abnorm

190 Essential tremor is the most common movement disorder an

191 Clinically Parkinson disease and essential tremor may be confused with each other but it

192 ease of the cerebellum or cerebellar system; essential tremor may be neurodegenerative; low gamma ami

193 hat the effects of electrical stimulation on essential tremor may be phase dependent, and that, in pa

194 These include the following: essential tremor may represent a family of diseases rath

195 Existing studies suggest that pathology in essential tremor might emerge from multiple cortical and

196 enotype in the traditional harmaline-induced essential tremor model.

197 , only ventrolateral thalamic stimulation in essential tremor modulated postural tremor amplitude acc

198 c to Parkinson's disease, but also occurs in essential tremor, most prominently for the coupling of a

199 tients with Parkinson's disease (n = 19) and essential tremor (n = 16), respectively.

200 subjects with Parkinson's disease (n = 20), essential tremor (n = 8) and psychogenic tremor (n = 7).

201 ects with Parkinson's disease (n = 11), with essential tremor (n = 9) and without a movement disorder

202 nts had a history of either isolated tremor (essential tremor, n = 2; benign tremulous Parkinson's di

203 rd treatment for laryngeal dystonia (LD) and essential tremor of the vocal tract (ETVT) is botulinum

204 urodegeneration such as Alzheimer's disease, essential tremor or drug-induced parkinsonism and hence

205 dramatically relieve tremor associated with essential tremor or Parkinson disease (PD).

206 S surgeries in 25 human patients with either essential tremor or Parkinson's disease, we acutely reco

207 blation, particularly to treat patients with essential tremor or Parkinson's disease.

208 .0312; ventrolateral thalamic stimulation in essential tremor, P=0.0137; two-tailed paired Wilcoxon s

209 ith possible Parkinson's disease (3.5%), and essential tremor-Parkinson's disease (3.0%).

210 solated rest tremor and (2) the diagnosis of essential tremor-Parkinson's disease during life.

211 kers for conversion from essential tremor to essential tremor-Parkinson's disease would be of conside

212 and connectivity between dystonic tremor and essential tremor patient cohorts to better understand di

213 nt drug therapies that alleviate symptoms in essential tremor patients (primidone, propranolol, and g

214 We retrospectively evaluated 118 essential tremor patients and five tremor-dominant Parki

215 This study demonstrates that SID in essential tremor patients is associated with both motor

216 Prior work using this paradigm in essential tremor patients produced exacerbation of grip-

217 tion-induced worsening of intelligibility in essential tremor patients with bilateral thalamic deep b

218 tremor control without speech impairment in essential tremor patients with thalamic DBS.

219 strate increased burst durations relative to essential tremor patients.

220 Monopolar reviews were conducted in 14 essential tremor patients.

221 abated completely in the treated hand in 81 essential tremor patients.

222 emor syndrome resembling the core symptom of essential tremor patients.

223 isorder Society on tremor coined a new term: essential tremor-plus (ET-plus).

224 h a clinical diagnosis of PS, non-PS (mainly essential tremor), probable DLB, and non-DLB (mainly Alz

225 eatment efficacy with the Quality of Life in Essential Tremor Questionnaire (ranging from 0 to 100%,

226 further 55 tremulous Parkinson's disease and essential tremor recordings.

227 je cell dendritic architecture and spines in essential tremor relative to control brains provides add

228 The pathophysiology of dystonic tremor and essential tremor remains partially understood.

229 Recent essential tremor research has given rise to several nove

230 th medication-refractory dystonic tremor and essential tremor, respectively.

231 ly of diseases rather than a single disease; essential tremor seems to be a disease of the cerebellum

232 arkinson's disease and in all four remaining essential tremor subjects but in none of the psychogenic

233 and encourage research into the creation of essential tremor subsets that are defined with respect t

234 ter in subjects with Parkinson's disease and essential tremor than in subjects without a movement dis

235 Kinetic tremor may be more prominent in essential tremor than postural tremor.

236 mbles other common tremor disorders (such as essential tremor) that occur in patients who have an oth

237 ogram at tremor frequencies suggests that in essential tremor the tremor is imposed on the active mus

238 Interestingly, in essential tremor, the increased distribution of climbing

239 cardinal feature of Parkinson's disease and essential tremor, the two most common movement disorders

240 tifying clinical markers for conversion from essential tremor to essential tremor-Parkinson's disease

241 ow of ideas from clinical observations about essential tremor, to their translation into scientific s

242 date of patients with Parkinson's disease or essential tremor undergoing deep brain stimulation surge

243 e ventralis intermedius thalamic nucleus for essential tremor underwent functional magnetic resonance

244 k contralateral motor score improvement, for essential tremor was located in the ventral intermediate

245 Essential tremor was present in persons either heterozyg

246 of abnormalities in Purkinje cell biology in essential tremor, we hypothesized that regressive change

247 rmometry) data acquired during treatments of essential tremor, we verified that our simulation framew

248 Patients with dystonic tremor and essential tremor were characterized by distinct function

249 These types of essential tremor were compared with patients having inte

250 Nine patients with essential tremor were divided clinically into two catego

251 sent, 15 patients with medication-refractory essential tremor were enrolled in a HIPAA-compliant pilo

252 ted with the primary sensorimotor regions in essential tremor, whereas in dystonic tremor, the correl

253 variability of SCN4A with the development of essential tremor, which adds ET to the growing list of n

254 ase functional independence in patients with essential tremor, who exhibit both mobility and cognitiv

255 Such differences in parkinsonian rest and essential tremor will be important in selecting future s

256 es were able to classify dystonic tremor and essential tremor with 89% area under the curve, whereas

257 discriminate Parkinson's disease tremor and essential tremor with high diagnostic accuracy.

258 cal diagnoses were essential tremor (93.5%), essential tremor with possible Parkinson's disease (3.5%

259 ents, age: 50-77 years) and 10 patients with essential tremor with thalamic electrodes (nine male and

260 tnessed a remarkable increase in research on essential tremor, with consequent advances in our unders

261 cortical activity in Parkinson's disease and essential tremor, with the greatest high-beta desynchron

262 tions in functional connectivity compared to essential tremor within higher-level cortical, basal gan

263 atment of migraine and action tremor (mainly essential tremor), worldwide.

264 >100 Hz, commonly used for parkinsonism and essential tremor, worsened incoordination, and frequenci