ライフサイエンスコーパス: establish

1 versively-conditioned responses has not been established.

2 support the dynamic phenotype remains to be established.

3 is (AAV) and severe renal involvement is not established.

4 nalysis, a molecular map of exercise will be established.

5 molar volume change with a pressure rise was established.

6 neous electron donor for denitrification was established.

7 residue-specific glycan profiles of EPO was established.

8 s required for normal function remains to be established.

9 ndividual neurotypical children has not been established.

10 odium-glucose cotransporter 2, have not been established.

11 sponsible mechanisms have not yet been fully established.

12 ature of how cells respond to them is poorly established.

13 nal microbiome in alcoholic hepatitis is not established.

14 ts of periodontal disease if further studies establish a causal relationship.

15 These findings establish a cellular mechanism for the representation of

16 hydrodynamics relative to spaceflight and to establish a comprehensive model of recovery after return

17 abolic tumour suppressor in liver cancer and establish a critical crosstalk between hepatocyte metabo

18 Collectively, these findings establish a critical role for Prdm12 in the anorexigenic

19 the use of micromagnetic immunoconjugates to establish a direct competitive assay between the m6A tar

20 capture and dCas9 mediated enhancer blocking establish a direct regulatory link between this enhancer

21 Together, these findings establish a HMGB2-TOP1cc-cGAS axis that enables cytoplas

22 In combination, these findings establish a key role for microbiome-dependent circadian

23 cent reporter characterization platform, and establish a library of 15 mutually orthogonal split inte

24 Here we establish a linear relationship between the heat and car

25 These findings establish a mechanistic understanding of LBL-lipid inter

26 The purpose of this investigation was to establish a method for isolation of human stem cells fro

27 (DPPA2/4) as epigenetic priming factors that establish a permissive epigenetic landscape at a subset

28 We establish a pH-dependent oligomerization pathway forming

29 Here, we establish a robust method for the identification of glob

30 We thus establish a simple mechanism for femtosecond spatiotempo

31 ted by combined nose and throat swabbing and establish a statistically significant correlation betwee

32 To establish a stem cell-based approach to restoring TM fun

33 Here, we establish a structural-molecular basis for these observa

34 nown exposure to TB were used as controls to establish a threshold to account for nonspecific/backgro

35 We established a biomarker signature and multiple protein r

36 We established a clinical and technical protocol for repeat

37 In this study, we established a diabetic humanized NOD-scidIL2Rgamma(null)

38 In this study, we established a highly efficient synchronization method fo

39 ed iSLK.219 cell model of KSHV infection and established a new infection model of primary lymphatic e

40 We established a novel bioelectrochemical platform to chara

41 Herein, we established a novel method to quantify SCFAs by coupling

42 We established a novel secretome analysis of cardiomyocytes

43 To develop this platform, we established a pan-transcriptome reference for B. juncea,

44 We established a possible role of PrimPol in tenofovir-indu

45 In this study, we established a protocol based on the HEV genotype 3 p6 (K

46 In addition, recent work has established a role for both the Kappa Opioid Receptor (K

47 We then established a scalable pipeline coupled with the SONICC

48 We established a subcommittee to develop response assessmen

49 toxicity experiments with (212)Pb-anti-mCD38 established a toxic activity of 277.5 kBq.

50 This work establishes a clear path to the next generation of two-s

51 e tools to modulate aGPCR-ligand binding and establishes a foundation for the development of aGPCR-ta

52 photosynthetic complexes in grana membranes establishes a foundation that could be adapted to study

53 This study establishes a precise genetic engineering platform for g

54 promising anterograde transsynaptic tool for establishing a comprehensive cell-atlas of the brain, al

55 However, establishing a firm link between macro-scale brain netwo

56 ghly dependent on the anchor group, with Ipa establishing a monolayer much more efficiently than COOH

57 results in chromatin dysregulation, thereby establishing a state of transcriptional plasticity that

58 d using rate constants of these reactions to establish accurate and robust laboratory parameters.

59 n, smoking, obesity and hormonal factors are established aetiological factors for HS.

60 low frequency; hypermutated tumors can only establish after the evolution of immune escape.

61 FDA-approved drug) in a CDI mouse model and establish an adequate dosage for treatment.

62 appeared, enabling the virus to successfully establish an infection.

63 We established an in vitro model for the induction of these

64 Collectively, our study establishes an in vivo model for studying how transforme

65 Establishing an effective PROMs program requires an unde

66 cannot be discerned from bulk measurements, establishing an efficient method for surveying cell popu

67 Mass spectrometry imaging (MSI) is an established analytical tool capable of defining and unde

68 y which CHIKV subverts antiviral immunity to establish and maintain a persistent infection may lead t

69 nected feed-forward transcriptional loops to establish and reinforce the cell-type-specific gene-expr

70 and economic impacts once nonnative species establish and spread.

71 stration regime for ADT has not been clearly established and incorporation of adjunctive upfront trea

72 hese local regrowths have not yet been fully established and main concerns include high postoperative

73 A similar motif is present in a number of established and newly identified cohesin ligands, includ

74 so, we are able to retrieve both previously established and novel biologically relevant patterns, de

75 data-driven motion-compensation approach was established and tested for (18)F-FDG PET brain imaging.

76 e feasibility of eradicating 60 new (not yet established) and 35 emerging (established with limited d

77 critical enzymatic reaction conditions were established, and the best results were found using tert-

78 clearance does not happen once infection is established, and this may be because of the very early f

79 , is an interferon-stimulated gene with well-established antiviral activity but limited mechanistic u

80 es and N-terminal cysteine residues has been established as a biocompatible reaction for site-selecti

81 ic agent Lipiodol, which has been previously established as an imaging biomarker for tumor response.

82 in Citrus trees that had been experimentally established as fully flowering or nonflowering.

83 , 200 mg twice a day); 150 mg once daily was established as the RP2D.

84 ioning (EBC), which relies on the ability to establish associations between stimuli, with the eyelid

85 The earliest connections are established autonomously.

86 A framework is established based on Tempel that enables us to predict t

87 Promoters serve a critical role in establishing baseline transcriptional capacity through t

88 s for developing a standardized approach for establishing benchmarks for relevant outcome measures in

89 ical findings can be considered to have been established beyond reasonable doubt.

90 terleukin-4 (IL-4), IL-5, and IL-13, are now established biological mechanisms in asthma.

91 hysiological connections are relatively well established, but less is known about how sensorimotor in

92 farmland and sparing land for nature is well-established, but the spatial overlap of this potential w

93 )Cr(15)Mo(14)Y(2)C(15)B(6) metallic glass is established by analyzing the crystal size distribution u

94 tion is initiated from specific origin sites established by dynamic events.

95 Theory predicts that when populations are established by few individuals, random founder effects c

96 unds in migration exceeded the maximum level established by Regulation EU/10/2011 (10 ng g(-1)).

97 Perhaps the most well established candidate signature is the P3b event-related

98 myopathic cTnI-G203S mice, but not mice with established cardiomyopathy, restored cardiac myocyte mit

99 se-ranging trial involving 286 patients with established cardiovascular disease and screening lipopro

100 3% underwent CE for suspected CD and 27% for established CD.

101 ses cyclizations utilizing a library of well-established chemical reactions and reagents.

102 Many intracellular bacteria can establish chronic infection and persist in tissues withi

103 The "ventilator-free days" score, is an established composite that equates ventilation on day 28

104 These findings establish conserved aspects of sex-biased brain developm

105 Furthermore, cognitive abnormalities are established core characteristics of schizophrenia.

106 Patients with established coronary artery disease or peripheral artery

107 In patients with established coronary artery disease, (18)F-NaF PET provi

108 reversal symmetry via a magnetic field; thus establishing CPA beyond its initial concept as the time-

109 for ligands with antimalarial activity, and establishes curation of data from screening assays, used

110 r diagnosis and compare their performance to established density measures.

111 als that incorporate particles with the well-established designer properties of MOFs and, therefore,

112 Twenty adults (median 71 years) with an established diagnosis of glaucoma were issued a tablet p

113 Gap junctions establish direct pathways for cells to transfer metaboli

114 Neuroimmunology, albeit a relatively established discipline, has recently sparked numerous ex

115 iple neurons of associative brain regions is established during development is unknown.

116 hether these continua are stable properties, established during development, or if they reflect acute

117 ntal organization of the vertebral column is established early in embryogenesis, when pairs of somite

118 remarkably strong connections to genes with established effects on CFTR trafficking and function and

119 ast cancer cells to identify the key players establishing epithelial-mesenchymal cell plasticity duri

120 cient guidance for policymakers charged with establishing evidence-based policy to determine whether

121 found to be in good agreement with the best established experimental measure of free volume.

122 ion and in vitro fertilization (IVF) methods established for Chinese cynomolgus macaques to generate

123 essment (ERA) that ideally builds on methods established for conventional chemicals to ensure alignme

124 e done using existing methods, such as those established for development of national surgical, obstet

125 me-level genome assembly and annotation were established for one of the most sensitive wild isolates,

126 inferiority of the Personalized Approach was established for the primary outcome 3-month cumulative S

127 The data also establish FRbeta as the first marker that distinguishes

128 g for additional complementary approaches to establish functionality.

129 ster utilization in this preclinical setting establish fundamental insights, laying the framework for

130 olaritons as a serious contender to the well-established GaAs platform for a wide range of applicatio

131 By providing a comprehensive overview on the established genetic tools, methods and applications we h

132 Carla (CVR) and Elina (EIZ) established Global ImmunoTalks in April this year; Hongb

133 trate that river deposition was already well established >3.7 Ga.

134 The established HCC mouse models were characterized at histo

135 scattering, and Monte Carlo simulations, we establish HoAgGe as a crystalline (i.e., nonartificial)

136 netic background on driver mutations is well established; however, the mechanisms by which the backgr

137 response of tumour spheroids formed from two established human cancer cell lines (HCT116 and CAL27) t

138 an retinal vascular endothelial cells and an established human endothelial cell line, we investigated

139 Furthermore, by establishing idiopathic RPL patient-specific human troph

140 chromatin regulators of gene silencing that establish immune cell identity and function.

141 ility of range-shifting prey to successfully establish in newly available habitat following climate w

142 gistry was a prospective observational study established in 2006 to evaluate perinatal outcomes in pr

143 A molecular diagnosis was established in 55 patients (51%).

144 ed risk alleles, weighted by allelic effects established in an independent population.

145 2 (SARS-CoV-2) transmission networks became established in Europe and North America.

146 Whilst mathematical modelling is well established in informing biological systems, many models

147 ture and exercise function have been largely established in men.

148 ndrogen receptor (AR) activity that has been established in preclinical models of HCC with the clinic

149 ures for primary radiomic analyses have been established in recent years, processing the resulting ra

150 prevented SARS-CoV-2 outbreaks from becoming established in these regions.

151 scribe an active poultry surveillance system established in Vietnam to identify the scope of influenz

152 As well as a firmly established increased risk of cardiovascular disease and

153 stance onset and remarkably reverses already established insulin-resistance.

154 that spatial integration can be achieved by establishing interdependencies among agents of different

155 Here, we establish isogenic human ESC-derived microglia-like cell

156 the high-order structure of proteins is now established, it can be challenging for beta-barrel prote

157 l corneas, 40 early-stage keratoconus and 83 established keratoconus.

158 maintaining or altering best practices, and establish key recommendations for the conduct and analys

159 Given the established link between perforin deficiency and primary

160 existence, thus, promoting their ability to establish long-term infections and disease.

161 However, establishing long-range interactions between multiple do

162 How VZV establishes, maintains and reactivates from latency is l

163 indicated that this was not attributable to established major allergenic components of the extracts

164 Here, using our recently established mammary specific Tet2 deletion mouse model,

165 ine resource managers in many locations have established marine protected areas or seasonal closures

166 We provide recommendations for establishing matched control group for proper effect siz

167 Although there is no cure or established means of prevention, effective treatment is

168 A well-established mechanism of CIN is the overproduction of ce

169 For the established mechanism, we compare and analyze the activi

170 n of the dopaminergic neuron DAN-i1 can both establish memory during training and acutely terminate l

171 These results establish MET(N375S) as a biologically distinct and clin

172 aphy-mass spectrometry profiling is the most established method for the analysis of organic residues,

173 Although there are numerous well-established methods for the determination of DP and F(A)

174 Established methods for whole-genome-sequencing (WGS) te

175 However, established methods with high spatiotemporal resolution

176 Establishing methods to identify candidate structures th

177 Its potency compares well with established MIF inhibitors, whereas msR4M-L1 does not in

178 Here, we use Drosophila, an established model for studies on triglyceride metabolism

179 hance Depression Outcomes (CO-MED, n = 665), Establishing Moderators and Biosignatures of Antidepress

180 Not only are previously established modifications observable by mass spectrometr

181 We addressed this issue in an established mouse model of Retinitis Pigmentosa caused b

182 Using the well-established mouse model of TB, our new data provide evid

183 This establishes multivalent, synergistic H3-tail binding cau

184 eal time in live cells, utilizing a recently established NanoBRET-based ligand binding assay.

185 elial growth factor-A (Vegf-A) is crucial to establishing NMJ reinnervation at the end target muscle.

186 g the costs/benefits of stocking-or removing established non-native populations-under a rapidly chang

187 These results challenge the well established notion of the P3b as a neural marker of awar

188 -Nur1 on heterochromatin prevents it from re-establishing nucleocytoplasmic compartmentalization.

189 at most synapses or about the mechanisms for establishing or maintaining this balance at specific set

190 We believe that this work establishes organic polaritons as a serious contender to

191 more direct forms of learning have been well established over the last century, we still lack a solid

192 re, testing a large sample (N = 72) using an established paradigm and a preregistered protocol, we fo

193 fundus examinations (DFEs) were assessed for established patients receiving optical coherence tomogra

194 ially in high-grade PanIN lesions but not in established PDAC.

195 s, which indeed should be further studied to establish possible correlations with chronic antipsychot

196 cancer immunotherapy from a pipe dream to an established powerful cancer treatment modality.

197 resenting three of the four clades that were established prior to angiosperm radiation.

198 but also for the biopharma industry and its established processes for discovering and developing new

199 Genetic parameters are established prognostic factors in chronic lymphocytic le

200 et according to six grades with a previously established prognostic ordinality: grade 1 = no disease

201 To establish proof-of-principle therapeutic effects, we tes

202 There is an urgent need to establish protocols specifically designed to overcome th

203 Established protocols for experimental detection and com

204 A PRS based on the 10 established PTC SNPs showed a stronger predictive power

205 We established rapid and reversible optogenetic control for

206 entral Africa, where efforts may necessitate establishing rapid conservation interventions postconfli

207 Our study, using a well-established rat model of alcohol dependence, ex vivo ele

208 However, once established, rats transitioned abruptly between aberrant

209 Besides binding to well-established receptors, an extended loop in the C-termina

210 e lattice parameter, in contrast with a more established relationship that suggests that the lattice

211 ently, no treatment options are available to establish remyelination.

212 Although obesity is an established risk factor for morbidity and mortality, the

213 Parental history of atopic disease is a well-established risk factor for the development of atopic de

214 tions, for which periodontitis and sleep are established risk factors.

215 Even in the absence of fully established risk prediction schemes and outcome studies

216 These findings establish robust materials basis, formation mechanism, a

217 es to regulate transcription beyond its well-established role in safeguarding the genomic integrity.

218 and express insulin-like peptides with well-established roles in regulating food intake and metaboli

219 antiomerically pure RJW100 derivatives: they establish RR-RJW100 as the stronger LRH-1 agonist and id

220 To establish sc-FLCCS, we first engineered and tested multi

221 ; subsequent genomic and functional analyses establish SERBP1 regulation role in metabolic routes pre

222 ation of such biosensors with extremely well-established silicon-based microcircuit chips offers a vi

223 eloping myofibers have on nuclear accrual to establish size, and the limits of adaptability in adult

224 nd hydrochlorofluorocarbons were measured to establish source signatures.

225 mice underwent dorsal wounding following an established splinted excisional skin wounding model.

226 lowed by delayed primary surgery (DPS) is an established strategy for women with newly diagnosed, adv

227 cess in legumes, and by some fungi that also establish symbiotic relationships with plants, notably t

228 We also establish synthesis of 8-hydroxygeraniol, the precursor

229 hallenging, especially for large tumors, and established systemic treatments are lacking.METHODSWe us

230 While hair cells in the cochlea are established targets of cisplatin, less is known regardin

231 vidence and potential alternatives on how to establish tau positivity (T+) for multiple tau-imaging t

232 Our study establishes TEADi as a resource for studying YAP1/TAZ-TE

233 lectrolysis to hydrogen and oxygen is a well-established technology, whereas fundamental advances in

234 Our results establish that air temperature is a necessary but not su

235 Our findings establish that evolution can produce new complex molecul

236 Here, we establish that partial time reversal transforms the beam

237 Taken together, these results establish that reachable-scale environments have a disti

238 These results establish that silent synapses are generated by an astro

239 Taken together, our results establish that the bioactive lipid LPA drives the expres

240 RNA complexes with mimimal sequence bias and establish that the crosslink can be reversed by phosphin

241 We establish that the social behaviour deficits in offsprin

242 These studies establish that the thrombin/fibrinogen axis is fundament

243 Although it is well established that EBOV results in severe organ damage, ou

244 It is well-established that food proteins, such as egg, soya, cow's

245 Genetically labeled mice established that L1 neurons are proprioceptors.

246 Early studies established that LDL (low-density lipoprotein) particles

247 Previous work has established that risk factors for lead exposure include

248 We established that SVB is ubiquitously expressed in plant

249 These findings established that the CMC/ALG binary blend polymer wafers

250 sk demands.SIGNIFICANCE STATEMENT It is well established that the high-level visual cortex is compose

251 We established that the immune-suppressive cytokine interle

252 ry and beta-secondary isotope effects, it is established that the isomerization of epoxides into ally

253 We have previously established that the Med1 Mediator subunit serves as a c

254 It has been established that these trends were driven by ozone deple

255 Although it is well-established that transcription factors bind to specific

256 the viral major capsid protein in PBCV-1 and establishes that a single protein A064R possesses the th

257 However, the present study establishes that another key step in central metabolism

258 mophilum IC has a low helical propensity and establishes that H2 binds directly to the coiled-coil 1B

259 This work establishes that precise gene editing to correct multipl

260 has been performed in order to successfully establish the asymmetric nature and enantiopurity of the

261 ckly merged with genetic studies in yeast to establish the basic mechanism of the eukaryotic cell div

262 However, more research is needed to establish the best treatment options for these high-risk

263 Encouragingly, we establish the capacity of our model to uncover in vivo a

264 atural enemies should be further explored to establish the conditions in which indirect defence gener

265 Aim of this study was to establish the disease severity and prognostic factors fo

266 Here, we establish the Drosophila border cells as a model for thi

267 dvances in pharmacological targeting of DUBs establish the enzyme family as targetable and provide a

268 ting material and substrate stereocontrol to establish the five contiguous stereocenters of (-)-bacto

269 ions on the Prismatic Basal interfaces which establish the lattice correspondence of the twin with a

270 ctin N-terminal acetyltransferase NAA80, and establish the modus operandi for NAA80-mediated actin N-

271 Furthermore, future studies are necessary to establish the role of the apparently avian-specific neur

272 We establish the significance of a sup-optimal paternal low

273 tic, archaeological, and genomic evidence to establish the timing of and conditions associated with e

274 chanics and mandible morphology to, firstly, establish the variation of this clade, secondly, relate

275 Overall, we have established the eicosanoid profiles linked to inhibition

276 Thus, this study established the proof of concept of targeting TF as a ne

277 Our structural and functional study establishes the extracellular loops as important structu

278 in the mTORC1-activated lung mesenchyme and establishes the importance of the WNT signaling pathway

279 onductivity of solids for decades, our study establishes the presence of sub-THz frequency tunneling

280 rine HCC models and corresponding cell lines establishes the role of driver genes in diverse contexts

281 Overall, this work establishes the spindle-independent function of NuMA in

282 In addition to establishing the different binding modes of aryl iodides

283 s were abrogated if caffeine was added after establishing the patch seal or with RyR block by 10 muM

284 chemistry and porosity, and electrolytes in establishing the reversible potassium sulfide K(2) S(n)

285 Although the pathway of PIC assembly is well established, the mechanism of assembly and the dynamics

286 ilable FEVAR, but further study is needed to establish their long-term durability.

287 elements (iron, copper, zinc and iodine) and establish their speciation in human milk.

288 Toll-like receptor 7 (TLR7) is an established therapeutic target in myriad autoimmune diso

289 ardiac resynchronization therapy (CRT) is an established therapy in patients with dilated cardiomyopa

290 ly improved sample throughput compared to an established thermal ionization mass spectrometry (TIMS)

291 This study establishes tipifarnib as a potential therapeutic option

292 lasma sintered iron based metallic glass was established to be from pre-existing nuclei as confirmed

293 ose that communities of 'rigor champions' be established to campaign for reforms of the research cult

294 ensivists and advanced practice providers of established U.S. and Canadian critical care organization

295 and Met(1)-linked ubiquitin chains in vitro, establishing UBA(Cez) as a functional ubiquitin-binding

296 lues between -2.5 and 2.5 were calculated to establish upper and lower limits of normal.

297 ble adaptation has proven to be difficult to establish using simplified models that are based on beha

298 l of family-wise significance may need to be established using separate permutations of the actual da

299 Yet it has not been established whether changing cultural values made modern

300 0 new (not yet established) and 35 emerging (established with limited distribution) species that pose