ライフサイエンスコーパス: ester bond

1 that have an amide replacement of the labile ester bond.

2 f the heme methyl and to trap it to give the ester bond.

3 ised for nucleophilic attack of the scissile ester bond.

4 ween Val(1) and Gly(2) in gramicidin A by an ester bond.

5 ked to endogenous DmSUMO-1 through an oxygen ester bond.

6 d that the Lp(a) was covalently linked by an ester bond.

7 the incoming ubiquitin acceptor to the thiol ester bond.

8 distance between the aromatic group and the ester bond.

9 on HCAs esterified to glucose via a carboxyl ester bond.

10 hallenge due to the chemical lability of the ester bond.

11 of the thioester with a more stable amide or ester bond.

12 branching point is located near the glycerol ester bond.

13 ally mediated by an unusual heme-polypeptide ester bond.

14 give RNA labelled through a native phosphate ester bond.

15 showed further evidence of the formation of ester bonds.

16 -derived unit that are linked by peptide and ester bonds.

17 y replacement of individual amide bonds with ester bonds.

18 -canonical side chains and either one or two ester bonds.

19 ure a "hairpin topology" with cross-strand w-ester bonds.

20 onal refinement, to the ultimate cleavage of ester bonds.

21 was found bound to the food matrix by ether/ester bonds.

22 cysteine glycerols, featuring various ether/ester bonds.

23 n is attached to hD4R through isopeptide and ester bonds.

24 erosion behavior of polymers with anhydride-ester bonds.

25 ydration is sufficient to drive synthesis of ester bonds.

26 they undergo biodegradation by hydrolysis of ester bonds.

27 spontaneous hydrolysis expected of arsenate ester bonds.

28 eins with peptide bonds being substituted by ester bonds.

29 e bond 26a, a hybrid azatetrapeptide with an ester bond 26b, and a hybrid azatripeptide with an ester

30 bond 26b, and a hybrid azatripeptide with an ester bond 28.

31 oligoalanine tailing makes the peptidyl-tRNA ester bond accessible for Pth-catalyzed hydrolysis.

32 itical role of V(o)-Zn(2+)-O-Fe(3+) sites in ester bond activation and C-O bond cleavage.

33 mation on fragments of lipid A, for example, ester bonded acyl chain dissociations, cross-ring cleava

34 by incorporation of more easily hydrolyzable ester bonds, additional dynamic bonds, or degradation ca

35 terminal splice junction rather than a (thio)ester bond, alleviating the need to form the initial (th

36 tage of the fast-forming and strong boronate ester bond, an archetypal example of dynamic covalent ch

37 channels can form between a subunit with an ester bond and a native subunit.

38 pyrene-aspirin (P-aspirin) with a cleavable ester bond and also facilitate loading the prodrug on go

39 for nanocarrier delivery by unshielding the ester bond and taking off the steric block.

40 duces biological activity, and that both the ester bond and the methyl group at the gamma-position of

41 -activity relationship clarifies the role of ester bond and triazol moiety of 15K in establishing nov

42 microenvironment, the programable-switches (ester bonds and disulfide cross-linking) of PDCM@PTX wer

43 ed with polymers, involving CO stretching of ester bonds and increased compatibility.

44 nerated depsipeptides, oligomers composed of ester bonds and peptide bonds that form readily under mi

45 bortezomib prodrugs with reversible boronic ester bonds and then incorporating the resulting prodrug

46 MALDI TOF-TOF analysis suggested covalent (ester bond) and non-covalent (strong hydrogen-bonding, m

47 e nonbridging oxygen atoms and in the P-O(R) ester bond, and solvent deuterium isotope effects, have

48 e distance between the aromatic ring and the ester bond, and the substitutions on the aromatic ring.

49 its ester bond in the region of the lipids' ester bonds, and associated dipole field and the aromati

50 Ether or ester bonds appeared to have only a minor effect on perm

51 ried water molecule on the alpha-face of the ester bond appears to be loosely bound or absent.

52 emical warfare agents containing phosphonate ester bonds are among the most toxic chemicals known to

53 d free GMT is recovered as the anhydride and ester bonds are hydrolyzed.

54 This study revealed that ester bonds are responsible for the polymerization of so

55 e heterodimeric channels, with only a single ester bond, are more easily characterized; the lone este

56 Polyesters, with reversible ester bonds, are already forerunners in plastic circular

57 arbon-heteroatom bonds, most often amide and ester bonds, are the standard method to link together tw

58 r lysis/ionization of an allylic diphosphate ester bond, as in limonene synthases, or protonation of

59 demonstrate that cleavage of the acylenzyme ester bond, as opposed to either the initial attack on t

60 Lability of the ester bonds, as estimated from second-order rate constan

61 ions of FAHFAs particularly isomers with the ester bond at the 9(th) carbon due to decreased FAHFA hy

62 protein splicing reaction by forming a (thio)ester bond at the N-terminal splice junction.

63 the adherends and reformation of the boronic ester bonds at the interface.

64 tion at pH < 3 to afford an Xaa-thiazolidine ester bond between a peptide containing a carboxyl termi

65 nally-modified heme with one single covalent ester bond between the 1-methyl heme substituent and Glu

66 The energy required for the formation of the ester bond between the amino acid carboxylate group and

67 ruits a release factor (RF) to hydrolyze the ester bond between the peptide chain and tRNA.

68 utational data, suggests a model for how the ester bond between the peptidyl tRNA and the nascent pep

69 e is covalently bound to the protein via two ester bonds between carboxylic side chains and heme meth

70 bohydrate esterase family 1 (CE1), hydrolyze ester bonds between ferulic acid (FA) and arabinose moie

71 mation of entanglements, hydrogen bonds, and ester bonds between pectin and starch, as confirmed by F

72 und form of the TGase 1 enzyme can also form ester bonds between specific glutaminyl residues of huma

73 actoperoxidase is attached to the protein by ester bonds between the heme 1- and 5-methyl groups and

74 ated several cyclic peptide motifs linked by ester bonds between the P2 and P1' or the P1 and P2' sid

75 l chemical reagents promote formation of the ester bonds between the walker and the track.

76 not depend on the intrinsic lability of the ester bond, but depends on both the distance between the

77 itigated by conjugating TTX to polymers with ester bonds, but the slow ester hydrolysis can result in

78 Cleavage of ester bonds by extracellular microbial hydrolases is con

79 ntibody by ultrafast cleavage of the boronic ester bond caused by the acidic condition of sprayed DES

80 e glycerophospholipids (PE, PS, and PC), via ester bond cleavage.

81 1)) and carboxyl (1570 cm(-1)) groups in the ester bond confirmed the successful starch esterificatio

82 The ester bond-containing analogues all folded into native-l

83 l characterization of two backbone-modified, ester bond-containing analogues of the homohexameric enz

84 onstrated the enzyme's efficacy in degrading ester bond-containing plastics, such as PET and bio-base

85 hat inhibition of the proteasome activity by ester bond-containing polyphenols may contribute to the

86 Here, we show that ester bond-containing tea polyphenols, such as (-)-epiga

87 tabilization could result in a weakened P-OR ester bond, contributing to the observed faster rate of

88 cificity for a 3'-O location of the scissile ester bond could be forced to the 2'-position by introdu

89 stic GDSL1 silencing leads to a reduction in ester bond cross-links and to the appearance of nanopore

90 c analysis suggests that similar domains and ester bond cross-links are widespread in Gram-positive b

91 in the liver via the enzymatic hydrolysis of ester bonds, elimination half-lives can range from sever

92 the first step, alpha(2)M* reforms its thiol ester bond, entering a reactive state that mimics the pr

93 om facile nonenzymatic hydrolysis of oxalate ester bonds (especially oxalate isosorbide bonds), which

94 iquitination of hydroxylated amino acids via ester bonds even when lysine residues are present on wil

95 We observed that NB ester bond exhibited significant rates of both photolysi

96 acid (histone deacetylase inhibitor) via an ester bond, exhibits antiangiogenic activity, being able

97 id by a coenzyme A (CoA) synthetase and (ii) ester bond formation between an isoprenoid alcohol and i

98 , an NRPS condensation enzyme that catalyzes ester bond formation between the SgcC2-tethered (S)-3-ch

99 in elongation intermediate analogues through ester bond formation catalyzed by CrpD-M2 C domain.

100 ntheses of FK228 featured macrocylization by ester bond formation from a seco-hydroxy acid.

101 This work reveals the structural basis for w-ester bond formation in RiPP biosynthesis.

102 posomal nanoparticles via reversible boronic ester bond formation to enhance the therapeutic index fo

103 Ester bond formation was confirmed by nuclear magnetic r

104 , and D302 (in hydroxyl group activation for ester bond formation) in the polymerization process.

105 ependent inhibitory effect on isopeptide and ester bond formation.

106 Using MS, we identified an ester bond formed between a thermolysin serine residue a

107 The esterase cannot hydrolyse the second ester bond from the 8-5-benzofuran monoester and therefo

108 ll wall degradation by cleaving at least one ester bond from the diferulate cross-links that exist be

109 The breakage of one or both ester bonds from dehydrodimer cross-links between plant

110 acids Lys, Arg, or His adjacent to backbone ester bonds generally promote RNA duplex thermal stabili

111 attaching EPA to sphingomyelin via an oxime-ester bond highly responsive to hydrolase cleavage.

112 d thiol-reactive) cross-linker with a labile ester bond (HL).

113 ndicating that they were not (only) based on ester bonds; however, most were cleaved by 6 m NaOH, whi

114 nserved base-pair plays an important role in ester bond hydrolysis during translation termination.

115 the specificity of the nZVI catalyst toward ester bond hydrolysis in PET, while BPA-PC, a carbonate-

116 We estimated kcat/Km for ester bond hydrolysis of P-site bound peptidyl-tRNA by R

117 combination of ester-amide bond exchange and ester bond hydrolysis, depsipeptides are enriched with a

118 efficiently driven by microorganisms through ester bond hydrolysis.

119 g is conducive to both substrate binding and ester bond hydrolysis.

120 odrug drastically accelerates intrabacterial ester-bond hydrolysis required for activating the antibi

121 Thr17 (P2) and Leu18 (P1) was replaced by an ester bond, i.e., -CONH-to-COO-.

122 However, the ester bond in (T)PUs might be sufficiently hydrolysable

123 ence properties as well as hydrolysis of the ester bond in both single- and double-stranded conformat

124 me that catalyses the formation of the FAHFA ester bond in mammals.

125 h a desolvation-induced weakening of the P-O ester bond in the ground state.

126 triazole formation and/or hydrolysis of the ester bond in the iminophosphorane intermediate to give

127 g the s-cis lactone ester bond to an s-trans ester bond in the polymer.

128 ine near the phosphate of the headgroup, its ester bond in the region of the lipids' ester bonds, and

129 discovery that O-series LNPs (containing an ester bond in the tail) that tend to deliver mRNA to the

130 t solvent-induced weakening of the phosphate ester bonds in any of the solvents tested, and this is u

131 r the formation of the three amide and three ester bonds in enterobactin using ATP, L-serine, and acy

132 drophilic PGMA chains to form phenylboronate ester bonds in mildly alkaline aqueous solution (pH appr

133 of activation by water, the surface boronic ester bonds in the PVA/BA film undergo fast debonding an

134 roup pKa (betalg = -1.23) arises from weaker ester bonds in the reactants as the pKa of the leaving g

135 The boronic ester bond is employed to cross-link the BMT with the ga

136 hy suggest that the carbon of the polyphenol ester bond is essential for targeting, thereby inhibitin

137 strategically different approach whereby the ester bond is formed intermolecularly at an early stage

138 containing both a disulfide and a sulfonate ester bond is grafted onto the surface of ordered mesopo

139 preceding Gly-191, after which the resulting ester bond is likely hydrolyzed.

140 The ester bond is somewhat unstable, which precluded further

141 The acyl ester bond is stabilized to hydrolysis through resonance

142 IgG-like fold and contains an unprecedented ester bond joining Thr and Gln side chains.

143 epared on hydroxy-bearing ITO surface via an ester bond linkage of polymer P3 to immobilize anti-TNF

144 rporated in the coumarin derivative near the ester bond linking both moieties in combination with the

145 acyl carboxylate anions via fragmentation of ester bonds linking the fatty acyl substituents at the s

146 The reversible boronate ester bond-mediated, thin (~75 nm) MIP-based biomimetic

147 but has been attempted with the inclusion of ester bonds (mivacurium) and binding agents that are in

148 4OT analogue containing a backbone amide to ester bond mutation between Ile-7 and Leu-8 [(OL8)4OT] w

149 The amide to ester bond mutation in (OL8)4OT effectively deleted a pu

150 bly, the five paired analogues with amide-to-ester bond mutations at structurally equivalent position

151 The amide-to-ester bond mutations in the two analogues in this study,

152 With amide-to-ester bond mutations introduced by total chemical synthe

153 We report a critical role of the sn-2 ester bond of glycerophospholipids in substrate recognit

154 site responsible for cleaving the aminoacyl-ester bond of misacylated Ala-tRNA(Pro) species.

155 causes preferential cleavage of the phospho-ester bond of peptides, particularly under conditions of

156 Hydrolysis of the ester bond of peptidyl-tRNA requires conformational chan

157 The ester bond of peptidyl-tRNA undergoes nucleophilic attac

158 holipase A2 (cPLA2) hydrolyzes the sn-2-acyl ester bond of phospholipids and shows a preference for a

159 olution interface to hydrolyze the sn-2 acyl ester bond of phospholipids.

160 pimelate moiety of biotin is cleavage of the ester bond of pimeloyl-acyl carrier protein (ACP) methyl

161 m the antagonistic bacterium by cleaving the ester bond of the cyclic lipopeptide involved.

162 ine lactonase, an enzyme that hydrolyzes the ester bond of the homoserine lactone of N-acyl homoserin

163 issues corresponding with stabilizing the CO ester bond of triacylglycerol.

164 T2282 gene product preferentially hydrolyzes ester bonds of substrates with intermediate carbon chain

165 on by ALP, but CES-catalyzed cleavage of the ester bond on the molecules results in disassembly of th

166 s with high membrane permeability often have ester bonds on their backbones.

167 alpha2M, reaction with proteases, the thiol ester bonds, or binding to LRP-1.

168 roups on the target surface to form amide or ester bonds, or is hydrolysed.

169 sized by the biomimetic acid-catalyzed epoxy ester[bond]ortho ester rearrangement.

170 The biomimetic epoxy ester[bond]orthoester rearrangement has been applied to

171 -k, thus exchanging peptide-bond amides with ester-bond oxygens which are incapable of hydrogen-bondi

172 OT and (OI7)4OT analogues each contained one ester bond per monomer that effectively deleted 12 backb

173 CES cleaves the ester bond pre-installed on the precursors to form the p

174 tion, it appears that substituting ether for ester bonds presents an additional barrier to proton flu

175 e (Abeta16-20) by replacing amide bonds with ester bonds prevents the aggregation of the peptide.

176 By mutagenesis, we show that loss of the ester bond reduces the thermal stability drastically and

177 Lipase hydrolysis of the ester bond released a fraction of the Fc redox active gr

178 osed to facilitate enzymatic cleavage of the ester bond, releasing free omega-hydroxyceramide for cov

179 ehavior results from weakening of the P-O(R) ester bond resulting from protonation, an effect which c

180 t the carboxy terminus of the peptide via an ester bond, resulting in a cyclic depsipeptide in contra

181 ed with tri(ethylene glycol) attached at the ester bond(s) for a 1:1 conjugate at the 17(3)-position,

182 robable catalytic base (Tyr150) and the acyl ester bond so as to block the approach of a potentially

183 ied analogue of ProtL containing an amide-to-ester bond substitution between residues 105 and 106 was

184 essor analogues, each containing an amide-to-ester bond substitution in the backbone of their polypep

185 Soil S inventories were largely and ester-bonded sulfates; they decreased from 1,623 +/- 354

186 better understand the steady state in which ester bond synthesis is balanced by hydrolysis.

187 The efficiency of ester bond synthesis was about 20% for 40 mM S-glyceroyl

188 affinities and trigger the hydrolysis of the ester bond that links the polypeptide with the P-site tR

189 e controlling mechanism is hydrolysis of the ester bond that links timolol to the PGT matrix, but oth

190 ng blocks and the presence of the main-chain ester bonds that can be chemically or biologically cleav

191 tilized to catalytically hydrolyze phosphate ester bonds, the utility of a zirconium(IV)-cluster-cont

192 For a given ester bond, there are separate secreted as well as cytop

193 g inhibitor mechanism depends on cleavage of ester bonds, this class of inhibitors may have advantage

194 cid (P-A1-Daba), converting the ring-closing ester bond to an amide bond.

195 uld be relieved by opening the s-cis lactone ester bond to an s-trans ester bond in the polymer.

196 chains (HCs) that are covalently bound by an ester bond to chondroitin sulfate (CS), which itself is

197 ylene glycol chains on SWNTs via a cleavable ester bond to obtain a water-soluble SWNT-PTX conjugate.

198 ons were made mainly on the aryl side of the ester bond to permit possible rapid labeling of the carb

199 hormone esterase (JHE), which cleaves the JH ester bond to produce methanol and JH acid.

200 that (a) covalent heme binding occurs via an ester bond to the heme 5-methyl group, (b) covalent bind

201 omega-hydroxyceramides covalently linked by ester bonds to cornified envelope proteins, most abundan

202 and eukaryotes use fatty acids attached via ester bonds to enantiomeric sn-glycerol 3-phosphate.

203 Borate forms ester bonds to Ser195, ethylene glycol (two bonds), and

204 ng was ascribed to elevated accessibility of ester bonds to the catalytic site of RoL due to increasi

205 ind their prosthetic heme covalently through ester bonds to two of the heme methyl groups.

206 e glutamic acid is linked, presumably via an ester bond, to a hydroxyl group on the heme 5-methyl gro

207 We conclude that both isopeptide and ester bond ubiquitination regulate proteasomal degradati

208 operoxy derivatives of oxidized PS, the sn-2 ester bond was positioned very close (<3 A) to the Ser27

209 le 6-O-feruloyl-d-glucose (FG), linked by an ester bond, was hydrolysed by pancreatin.

210 modimer Q2, which was tethered by reversible ester bonds, was particularly potent (IC(50) approximate

211 ich Thr4, the residue involved in the depsi (ester) bond, was replaced with either diaminopropionic a

212 trobenzhydryl (BHNB) groups in a photolabile ester bond were synthesized.

213 Leu44, or Ala49 and Ile50 are replaced with ester bonds were generated by incorporating alpha-hydrox

214 The ester bonds were incorporated in an alternating fashion

215 ges, wall lignification and decreased methyl ester bonds, were verified by direct analyses.

216 through both the amino acid scaffold and the ester bond, which is commonly used to link drug molecule

217 alently attached to Ogamma of Thr 302 via an ester bond, which is consistent with the increased mass

218 for polyester PUR's degradation because the ester bonds will be cleaved.

219 Replacing the ring-closing ester bond with an amide bond had little or no effect on

220 contrary to a previous report, replacing the ester bond with an amide bond significantly reduces biol

221 rine, effectively replacing the ring-closing ester bond with an amide linkage or with a primary ester

222 10 of this motif auto-catalytically forms an ester bond with the heme 5-methyl, and the immobilized G

223 -dicyclopentadiene derivatives linked by the ester bonds with tethers are highly regio- and stereosel

224 s are embedded within the polyamide and form ester bonds with trimesoyl chloride, one of the monomers

225 al bonds in the polymer products, other than ester bonds, with NMR spectroscopy.

226 eria can synthesize glycerolipids with ether/ester bonds, yet the complexities of their lipidome remo