ライフサイエンスコーパス: estrone

1 -1) for the conversion of androstenedione to estrone).

2 occurred during the irradiation of 3-acetyl estrone.

3 19-aldehyde androstenedione intermediates to estrone.

4 ddle cerebral artery occlusion (MCAO) as was estrone.

5 ated in part by alterations in serum PTH and estrone.

6 e activity and can synthesize estradiol from estrone.

7 larity analytes including both estradiol and estrone.

8 d a 6.8% (95% CI: -12.7%, -0.6%) decrease in estrone.

9 , geraniol, umbelliferone, pregnenolone, and estrone.

10 catalyzes the inactivation of estradiol into estrone.

11 tives, the main photoproducts, together with estrone.

12 with lower risk (top vs. bottom quartile RR: estrone = 0.52; 95% CI, 0.30-0.88; estradiol = 0.51; 95%

13 ion limits of the method were 0.045 ng/L for estrone, 0.086 ng/L for 17beta-estradiol, 0.030 ng/L for

14 ng to a total synthesis of the steroid (+/-)-estrone 1 and to a synthesis of 14-epiestrone 40 are des

15 ich, on deprotection using BBr(3) gave (+/-)-estrone 1.

16 he A2/A2 genotype to have elevated levels of estrone (+14.3%, P = 0.01), estradiol (+13.8%, P = 0.08)

17 ds (carbamazepine), and steroidal estrogens (estrone, 17-beta-estradiol, estriol, and 17-alpha-ethiny

18 product ion spectra of the PS derivatives of estrone, 17alpha-ethinylestradiol, equilin, and equileni

19 In WTP influents, estrogens (estrone, 17beta-estradiol, and estriol), androgens (andr

20 The estrogens included for study were estrone, 17beta-estradiol, estriol, 17alpha-ethinylestra

21 irolepine (505 Da), retrorsine (351 Da), and estrone (270 Da), to demonstrate some important aspects

22 ase activity, a number of novel analogues of estrone 3-O-sulfate possessing sulfate surrogates were s

23 r endogenous estrogen sulfates in the human, estrone 3-sulfate (E1-3S), estriol 3-sulfate (E3-3S), an

24 r influence on OATP2B1-mediated transport of estrone 3-sulfate and for their impact on CYP3A4 promote

25 g the cellular uptake of OATP1A2 substrates, estrone 3-sulfate and two delta-opioid receptor agonists

26 Hydrolysis of estrone 3-sulfate by steroid sulfatase is an important a

27 rom human, mouse, or skate) generated robust estrone 3-sulfate transport activity.

28 dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-bet

29 skate proteins by measuring transport of [3H]estrone 3-sulfate.

30 cholesterol epoxides (12.3 mumol/rat) and of estrone-3,4-quinone (30 mumol/rat)were 10- and 25- fold

31 xide), and 1,5(10)estradiene-3,14,17-trione (estrone-3,4-quinone).

32 -alpha-epoxide, cholesterol-beta-epoxide, or estrone-3,4-quinone.

33 activate two distinct estrogen glucuronides, estrone-3-glucuronide and estradiol-17-glucuronide, to e

34 , inversely associated with weekly levels of estrone-3-glucuronide and human chorionic gonadotropin.

35 ome fertility monitors that measured urinary estrone-3-glucuronide and luteinizing hormone (LH).

36 an chorionic gonadotropin and inversely with estrone-3-glucuronide and pregnanediol-3-glucuronide.

37 cted to assess human chorionic gonadotropin, estrone-3-glucuronide, and pregnanediol-3-glucuronide.

38 ase (STS) in comparison to a lead inhibitor, estrone-3-O-methylthiophosphonate (E1-3-MTP).

39 k from this laboratory, it was reported that estrone-3-O-sulfamate irreversibly inhibits a new potent

40 t estrone sulfatase inhibitors, most notably estrone-3-O-sulfamate.

41 Kinetic analysis showed that estrone-3-sulfate and SR101 are transported by OATP1A2 a

42 Docking studies using the substrate and estrone-3-sulfate mimics that are active inhibitors indi

43 A single estrone-3-sulfate molecule is bound in a pocket located

44 Para-aminohippurate (PAH) and estrone-3-sulfate transport across the bovine ciliary bo

45 itutions (S267X) with three substrates (TCA, estrone-3-sulfate, and rosuvastatin).

46 share the same binding site as the substrate estrone-3-sulfate.

47 detoxifies genotoxic 4-OH-estradiol and 4-OH-estrone (4-OHE(1)) with barely detectable 17beta-estradi

48 ver microsomal glucuronidation of estradiol, estrone, 4-aminophenol, and 4-nitrophenol by 103, 187, 1

49 bited the uterotropic effect of estradiol or estrone (45 or 75 ng/mouse, i.p. once daily for 3 days)

50 um was analyzed for testosterone, estradiol, estrone, 5alpha-androstane-3alpha, 17beta-diol-glucuroni

51 improved estrone retention while decreasing estrone adsorption to membranes.

52 (Z)- and (E)-diethylstilbestrol, hexestrol, estrone, alpha-estradiol, and 17-ethynylestradiol) is sh

53 High concentrations of equilin or estrone also attenuated the submaximal neuronal injury i

54 mulating hormone and to 17beta-estradiol and estrone, although the latter estrogen has a much lower a

55 > or = 30) had 35% higher concentrations of estrone and 130% higher concentrations of estradiol comp

56 found to contain florfenicol, pyrimethamine, estrone and 17beta-estradiol at levels from 0.095 to 2.7

57 For comparison, estrone and 17beta-estradiol were modeled and are likely

58 Six additional putative dimers between estrone and 17beta-estradiol with structures similar to

59 milar efficacy to 17 beta-estradiol, whereas estrone and 2-methoxyestriol were less effective.

60 volving the irradiation of some 3-(2-alkenyl)estrone and 3-(2-alkenyl)-17-norestrone derivatives unde

61 ently contaminated by the classical estrogen estrone and a variety of EDCs produced by plants (phytoe

62 hod was demonstrated by the carboxylation of estrone and by the synthesis of an unsymmetrically o,o'-

63 All isoflavone doses resulted in lower serum estrone and E(2) concentrations in the high-estrogen env

64 Estrone and equol persisted along the waste disposal rou

65 Higher urinary estrone and estradiol levels were strongly significantly

66 5% on average and removed significantly more estrone and estradiol than nonaugmented filters.

67 glucuronide and estradiol-17-glucuronide, to estrone and estradiol, respectively.

68 tho-arylation of diethyl carbamate-protected estrone and estriol with aryl iodides gives the 2-arylat

69 A preferential hydroxylation of estrone and increased oxidation of testosterone in patie

70 15 estrogens and estrogen metabolites (EM): estrone and its 2-, 4-, and 16alpha-hydroxy and 2- and 4

71 yet is capable of simultaneously quantifying estrone and its 2-, 4-methoxy and 2-, 4-, and 16alpha-hy

72 This method is capable of quantifying estrone and its 2-, and 4- and 16alpha-hydroxy and its 2

73 rine, yet is able to simultaneously quantify estrone and its 2-methoxy and 2-, 4-, and 16alpha-hydrox

74 The positive association of caffeine with estrone and its inverse association with bioavailable te

75 of estrone, whereas charge repulsion between estrone and negative functional groups of the membrane d

76 erum levels of DHEA, DHEAS, testosterone and estrone and substantially alters the patterns of correla

77 ly, their urinary excretion of estradiol and estrone and their 2-hydroxy metabolites were 12-28% lowe

78 the holo form and as ternary complexes with estrone and with the first potent, nonsteroidal inhibito

79 l substituted 4-chromanone moieties fused to estrone (and 17-norestrone) in good yields.

80 ens from 19-norsteroids, the 2-hydrogen from estrone, and (in this case) the 1-, 5beta-, and 9beta-hy

81 Prediagnostic concentrations of estradiol, estrone, and 13 metabolites were measured in 1,298 postm

82 lestrone (ZYC-26), with its parent estrogen, estrone, and an expected non-neuroprotective 3-O-methyl

83 d serum levels of DHEA, DHEAS, testosterone, estrone, and cortisol were measured in the DHEA and plac

84 Linearity for dansylated estriol, estrone, and estradiol was excellent over the estrogen r

85 s that are distinct from diethylstilbestrol, estrone, and estradiol.

86 mplete within 10 min for dansylated estriol, estrone, and estradiol.

87 chemicals, particularly 17beta-estradiol and estrone, and fish exposed to the postupgrade effluent in

88 ion of bioactive molecules such as procaine, estrone, and hymecromone demonstrates the robustness of

89 centrations of HM protein, lactose, insulin, estrone, and progesterone, infant total intakes of fat (

90 rum levels of DHEA, DHEAS, testosterone, and estrone, and regression analyses demonstrated that level

91 lysis, baseline and week 12 serum estradiol, estrone, and sex hormone-binding globulin (SHBG) concent

92 Estradiol, estrone, and sex hormone-binding globulin levels increas

93 . injection of 100 or 300 ng of estradiol or estrone, and these levels were decreased by 30-60% in an

94 en 6 and 10 and chemical formulas similar to estrone- and estradiol-like compounds.

95 However, analytes including estrone, androstenedione, progesterone, and equol remain

96 Endogenous estradiol and estrone are linked causally to increased risks of breast

97 We determined whether increases in serum estrone as a function of treatment predict increases in

98 eviated synthesis of a pyridyl derivative of estrone, as well as in a prototypical nitrogen scan.

99 intake was positively associated with plasma estrone before and after adjustment for confounders (r =

100 bundant than androgens or progesterone, with estrone being the predominant estrogen species.

101 hydrates (beta = -6.0; 95% CI: -10.2, -1.8), estrone (beta = -9.9; 95% CI: -14.5, -5.4), estradiol (b

102 e last hormone therapy use, higher levels of estrone (beta = 0.0013, p = 0.014), estradiol (beta = 0.

103 HA concentration determined the amount of estrone bound to HA and hence affected estrone retention

104 cted with MNU, and treated with estradiol or estrone by a continuous-release, subcutaneous Silastic i

105 d conversion of estradiol to the less-active estrone by HSD IV induction may explain how phthalate ex

106 NADPH-dependent metabolism of estradiol and estrone by liver microsomes of BHA-treated animals as de

107 may be the conversion of estrone sulfate to estrone by the enzyme estrone sulfatase.

108 linear regression to determine whether serum estrone changes predicted mammographic percent density c

109 Outcomes were estrone concentration (primary) and estradiol, free estr

110 The serum estrone concentration was significantly higher (P<.05) a

111 st positive relation between PAI-1 and serum estrone concentrations (rs = 0.29).

112 urinary pregnanediol-3-glucuronide (PdG) and estrone conjugate (E(1)C) levels.

113 centrations of estrone (E1), estradiol (E2), estrone conjugates, androstenedione, and testosterone we

114 Increases in the concentration of estrone could be observed downstream from potential sour

115 The electron density in the estrone crystal has been described with the multipole mo

116 Compared with controls, estrone decreased 9.6% (P = .001) with diet, 5.5% (P = .

117 ts, such as ambroxide, menthofuran, boldine, estrone, dehydroabietylamine, 9-allogibberic acid, and s

118 atherosclerosis and increasing quartiles of estrone, dehydroepiandrosterone sulfate, or androstenedi

119 monstrated previously that the sulfamoylated estrone derivative 2-methoxyestrone-3-O-sulfamate (2-MeO

120 st cancer cells in vitro, whereas the parent estrone derivative, 2-methoxyestrone, did not.

121 lied for the late-stage functionalization of estrone derivative.

122 The estrone derivatives also underwent 6beta-hydroxylation,

123 sulfamoylation on the anticancer activity of estrone derivatives and to elucidate their mechanism of

124 X-ray structures of the cholesterol and estrone derivatives are discussed.

125 er antimicrotubule agents, the sulfamoylated estrone derivatives induced BCL-2 and BCL-XL phosphoryla

126 In each assay, the sulfamoylated estrone derivatives were >10-fold more potent than their

127 The sulfamoylated estrone derivatives were also significantly more potent

128 ), 6b (or 6a), and Dane's diene (15, to give estrone derivatives) or N-benzyl-N-(cyclohexylethynyl)-4

129 This pathway afforded the ortho-acyl estrone derivatives, the main photoproducts, together wi

130 In addition, novel estrone-derived phainanoid analogues have been prepared.

131 enic compounds such as ethinyl estradiol and estrone did not have any effect on TNFalpha-induced VCAM

132 d for by baseline TAS, serum ferritin, serum estrone, dietary zinc, and dietary meat, fish, and poult

133 versely associated with plasma estradiol and estrone during the luteal phase of the menstrual cycle.

134 two groups of women was greater than that in estrone (E(1)), estradiol (E(2)) and estriol (E(3)).

135 Physiological estrogens, including estrone (E(1)), estradiol (E(2)), and estriol (E(3)), fl

136 Mean levels of circulating estrone (E(1)), estradiol (E(2)), and estrone sulfate de

137 the NADPH-dependent 16alpha-hydroxylation of estrone (E(1); at 10 nM to 200 microM substrate concentr

138 and results were compared with full agonists estrone, E(2), and estriol, a benchmark partial agonist

139 Environmental endocrine disruptors such as estrone (E1) and beta-estradiol (E2) are excreted in hum

140 nogenic 4-hydroxy catechol estrogens (CE) of estrone (E1) and estradiol (E2) to catechol estrogen-3,4

141 Estrone (E1) and trendione (TD) were detected as primary

142 esulted in a significant increase in urinary estrone (E1) excretion, whereas estradiol (E2), estriol

143 ogen-sensitive breast cancer by transforming estrone (E1) into estradiol (E2).

144 Higher estrone (E1) levels and carrying the APOE epsilon4 allel

145 tive metabolism of 17beta-estradiol (E2) and estrone (E1) to catechol estrogens (2-OHE2, 4-OHE2, 2-OH

146 ), which catalyzes the reduction of inactive estrone (E1) to the active 17beta-estradiol in breast ti

147 entrations and loading on the degradation of estrone (E1) were examined under various conditions in b

148 rements of laccase for the transformation of estrone (E1), 17beta-estradiol (E2), and 17alpha-ethinyl

149 imultaneous determination of four estrogens [estrone (E1), 17beta-estradiol (E2), estriol (E3), and 1

150 A third steroid, estrone (E1), also can occur at high concentrations in s

151 one, androstenedione (AD), testosterone (T), estrone (E1), and 17beta-estradiol (E2), and eight relat

152 f the steroid estrogens beta-estradiol (E2), estrone (E1), and alpha-ethynylestradiol (E2) in wastewa

153 E2 and its primary degradation intermediate, estrone (E1), are largely unknown.

154 alpha-E2), 17beta-estradiol (17beta-E2), and estrone (E1), are routinely detected in surface water ne

155 aptamers bind E2 and a structural analogue, estrone (E1), equally well and are up to 74-fold selecti

156 during anastrozole plasma concentrations of estrone (E1), estradiol (E2), estrone conjugates, andros

157 activity, we expanded our testing to include estrone (E1), estriol (E3), progesterone, and dexamethas

158 Incubation with dihydrotestosterone (DHT), estrone (E1), or estradiol (E2) at 10(-7) M for 30 min s

159 he free estrogens, 17beta-estradiol (E2) and estrone (E1), respectively.

160 estrogens [17beta-estradiol (17beta-E2) and estrone (E1)] and two synthetic estrogen mimics [zeranol

161 d NADPH-dependent oxidation of estradiol and estrone, enhanced the in vivo metabolism of these estrog

162 During the irradiation of 3-benzoyl estrone, epimerization of estrone through the Norrish ty

163 compounds, E2, diethylstilbestrol (DES), and estrone (EST), activated expression of the reporter gene

164 ermine whether removal of natural estrogens (estrone, estradiol, and estriol) and overall SSF perform

165 3 months, exercisers experienced declines in estrone, estradiol, and free estradiol of 3.8, 7.7, and

166 12 months of 11.9, 13.7, and 16.7% for serum estrone, estradiol, and free estradiol, respectively.

167 determined the levels of aromatase activity, estrone, estradiol, and tumor size in patients pre-AI an

168 erone sulfate, sex hormone-binding globulin, estrone, estradiol, C-peptide, insulin-like growth facto

169 spectrometry was used for the separation of estrone, estradiol, estriol, 16-epiestriol, 17-epiestrio

170 selected for study including four estrogens (estrone, estradiol, estriol, and ethinylestradiol), eigh

171 rbamate directing group furnishes 2-arylated estrone, estradiol, or estriol depending on the method u

172 riminatory ability as indicators of estriol, estrone, estradiol, or progesterone levels.

173 protein, lactose, and glucose) and hormones (estrone, estradiol, progesterone, leptin, adiponectin, a

174 circumference ratio, with concentrations of estrone, estradiol, testosterone, SHBG, dehydroepiandros

175 Four steroidal estrogens (17beta-estradiol, estrone, estriol, and 17alpha-estradiol) were tested in

176 Estradiol, bioavailable estradiol, estrone, estrone sulfate, androstenedione, testosterone,

177 uated whether inclusion of plasma estradiol, estrone, estrone sulfate, testosterone, dehydroepiandros

178 orders of magnitude for 17beta-estradiol and estrone following chlorination but increased 2 orders of

179 nd EXE-cys showing significant inhibition of estrone formation (63% each) at 10 uM.

180 d 17beta-DHE-cys all exhibited inhibition of estrone formation at both 1 uM and 10 uM concentrations,

181 Estrone formation was used as a measure of aromatase act

182 olysis of E2-3G and its oxidized metabolite, estrone glucuronide (E1-3G), both of which were transfor

183 ons in estrogen levels, by measuring urinary estrone glucuronide (E1G) in the periovulatory and lutea

184 onal effects of a CYP3A haplotype on urinary estrone glucuronide (E1G) levels and tested for an assoc

185 r-effluent irrigation, only imidacloprid and estrone had concentrations that resulted in observable d

186 ectrostatic potential (ESP) distributions of estrone have been determined using X-ray diffraction ana

187 f various drug analogues (e.g., cholesterol, estrone, ibuprofen, and naproxen).

188 Solute-solute interactions between HA and estrone improved estrone retention while decreasing estr

189 Both 17 beta-estradiol and estrone improved retention on an equimolar basis in a do

190 port of 4-nonylphenol, 17beta-estradiol, and estrone in a 10-km reach of the Redwood River in southwe

191 ABAD is to maintain the balance of estradiol/estrone in neurons.

192 es (17alpha-estradiol, 17beta-estradiol, and estrone) in aqueous solutions blended with dairy lagoon

193 wo prototypical aglycones, p-nitrophenol and estrone, in intact and digitonin-treated microsomes.

194 ta-HSD1, the enzyme catalyzing conversion of estrone into estradiol.

195 Estrone (k(stream) = 0.6 +/- 0.8 day(-1)) and 4-nonylphe

196 hat metabolites derived from cholesterol and estrone lack tumorigenic activity in the rat mammary gla

197 ase of 2.95% per 100 pg/mL increase in serum estrone level (P =.0003).

198 Greater increase in serum estrone level as a function of treatment is a significan

199 density increased with increasing change in estrone level in the EPT groups, but not in the CEE grou

200 in was also positively correlated with serum estrone levels (r(s) = 0.38) among HRT nonusers.

201 However, estrone levels decreased after alcohol and placebo in wo

202 epiandrosterone sulfate (DHEA-S) and reduced estrone levels in KC patients compared to healthy contro

203 sured mammographic percent density and serum estrone levels in participants in the Postmenopausal Est

204 of alcohol ingestion on plasma estradiol and estrone levels.

205 tion had low concentrations of two hormones (estrone <0.8 to 2.23 ng L(-1) and androstenedione <0.8 t

206 s as an in vitro model, 4-hydroxyestrone, an estrone metabolite with little estrogenic activity, is f

207 of 4- and 16alpha-hydroxylated estradiol and estrone metabolites.

208 hree-step synthesis of the tricyclic core of estrone methyl ether.

209 The use of a boronate group on an estrone molecule allows for activation of gene expressio

210 We observed that in contrast to estrone, neither ZYC-26 nor ZYC-23 bound to either estro

211 epimerization of ortho-regioisomer 2-acetyl estrone occurred during the irradiation of 3-acetyl estr

212 nto the hippocampus of 17 beta-estradiol and estrone on retention of T-maze footshock avoidance in fe

213 various human cytochrome P450 isoforms with estrone or 17beta-estradiol alone or two estrogens in co

214 Treatment of HOSE or OCa cells with estrone or 17beta-estradiol at 10(-8) M for a period of

215 evaluation of novel inhibitors based on the estrone or estradiol template.

216 siologic concentrations of 17beta-estradiol, estrone, or equilin attenuated neuronal loss due to prol

217 directly associated with a decrease in serum estrone (P < 0.01, R(2) = 0.50).

218 ds, including L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-naphthol.

219 e intervention, concentrations of estradiol, estrone, progesterone, 17-OH progesterone, testosterone,

220 nancy (<140 days gestation) serum estradiol, estrone, progesterone, and testosterone and breast cance

221 They provided serum for free estradiol, estrone, progesterone, free testosterone, and sex hormon

222 Estrone quinol was also equipotent with its parent estro

223 also underwent 6beta-hydroxylation, but only estrone quinol yielded a second product consistent with

224 gation of the chemical reactivity of Gen and estrone quinones to determine the chemical differences o

225 st-to-thigh circumference ratio ((r = 0.24), estrone ((r = 0.18), and estradiol ((r = 0.28) (albumin-

226 Concentrations of estrone ranged from between the detection and quantifica

227 The ability of UGT1A10 to glucuronidate estrone represents only the second example of a human es

228 osterone, corticosterone, cortisol, and beta-estrone, respectively, and with an average relative stan

229 of 17alpha-estradiol, 17beta-estradiol, and estrone, respectively.

230 functional groups of the membrane dominated estrone retention above the pK(a).

231 nt of estrone bound to HA and hence affected estrone retention based on the mechanism of size exclusi

232 interactions between HA and estrone improved estrone retention while decreasing estrone adsorption to

233 administration also inhibited estradiol- or estrone-stimulated [3H]thymidine incorporation into uter

234 otecting groups and, as demonstrated with an estrone substrate, does not perturb proximate ketones, w

235 Estrone sulfatase (ES; 562 amino acids), one of the key

236 e synthesized and evaluated as inhibitors of estrone sulfatase (STS) in comparison to a lead inhibito

237 The inhibition of MDA-MB-231 cell estrone sulfatase activity by this compound was found to

238 famoyl)-N-alkanoyl tyramines to inhibit: (a) estrone sulfatase activity in intact cultures of human b

239 the test compounds (1 microM) inhibited the estrone sulfatase activity of intact MDA-MB-231 cells; h

240 n some of the requirements for inhibition of estrone sulfatase activity, a number of novel analogues

241 fluence the ability of a compound to inhibit estrone sulfatase activity.

242 nes for the inhibition of breast cancer cell estrone sulfatase activity.

243 yl tyramine for the inhibition of MDA-MB-231 estrone sulfatase activity.

244 Thus, inhibitors of estrone sulfatase have potential for the treatment of es

245 r data support the concept that nonsteroidal estrone sulfatase inhibitors may be useful as therapeuti

246 l agents have been developed that are potent estrone sulfatase inhibitors, most notably estrone-3-O-s

247 famoyl)-N-alkanoyl tyramines as nonsteroidal estrone sulfatase inhibitors.

248 of estrone sulfate to estrone by the enzyme estrone sulfatase.

249 est compounds (10 microM) in the presence of estrone sulfate (1 microM) as the only source of estroge

250 zeta, increased both OAT3-mediated uptake of estrone sulfate (ES) and PKCzeta activity.

251 Treatment with the STS substrate estrone sulfate also improved metabolic functions in bot

252 edly reduced uptake of the OATP-C substrates estrone sulfate and estradiol 17beta-d-glucuronide.

253 the short OATP2B1 variant toward substrates estrone sulfate and rosuvastatin are similar to the well

254 ic anions such as p-aminohippurate (PAH) and estrone sulfate as well as the basic compound, cimetidin

255 lating estrone (E(1)), estradiol (E(2)), and estrone sulfate decreased to 11%, 22%, and 13% of baseli

256 -33 blocked the uterine weight stimulated by estrone sulfate in ovariectomized mice by 69% and the ST

257 he suppressed levels of plasma estradiol and estrone sulfate in postmenopausal women with early ER-po

258 For example, estrone sulfate levels in quintiles 1-5 of metabolic equ

259 breast cancer cells may be the conversion of estrone sulfate to estrone by the enzyme estrone sulfata

260 Estrone sulfate uptake in oocytes expressing any one of

261 Estrone sulfate was statistically significantly associat

262 Baseline values of estradiol and estrone sulfate were significantly correlated with BMI (

263 strates MK571, probenecid, taurocholic acid, estrone sulfate, and bromosulfophthalein and inhibited b

264 The uptakes of p-aminohippurate (PAH), estrone sulfate, and ochratoxin A were approximately 10-

265 or probenecid was observed for taurocholate, estrone sulfate, and para-aminohippurate in renal slices

266 Estradiol, bioavailable estradiol, estrone, estrone sulfate, androstenedione, testosterone, dehydroe

267 parately, were able to take up taurocholate, estrone sulfate, digoxin, and prostaglandin E(2), but no

268 13, and r = 0.30; P = .035 for estradiol and estrone sulfate, respectively), it was not with anastroz

269 ort function for the non-bile acid substrate estrone sulfate, suggesting this position may be part of

270 Estrone sulfate, testosterone, and prolactin were select

271 ther inclusion of plasma estradiol, estrone, estrone sulfate, testosterone, dehydroepiandrosterone su

272 eceptor-positive disease (selected hormones: estrone sulfate, testosterone, prolactin, and SHBG; chan

273 COS-7 cells by measuring the uptake of [(3)H]estrone sulfate.

274 n to the large hydrophobic organic substrate estrone sulfate.

275 k (odds ratio doubling, 0.82 [SHBG] to 1.37 [estrone sulfate]).

276 ns including extracellular glutamate (OAT4), estrone-sulphate and bromosulphothalein (both OAT4 and O

277 hours with 10 nM of either 17beta-estradiol, estrone, testosterone, 5alpha-dihydrotestosterone, 5alph

278 Estradiol, estrone, testosterone, luteinizing hormone (LH), follicl

279 The rate of 2-hydroxylation of estradiol and estrone (the major metabolic pathway) was increased by 2

280 ation of 3-benzoyl estrone, epimerization of estrone through the Norrish type I reaction occurred, pr

281 yme (17beta-HSD1) catalyzes the reduction of estrone to estradiol and is expressed in malignant breas

282 The reduction of estrone to estradiol, the most potent estrogen in human,

283 Estradiol or estrone treatment reduced the incidence of cataractous e

284 epresents only the second example of a human estrone UGT.

285 Conversion of androstenedione to estrone (under single turnover conditions) generated a p

286 A2/A2 genotype and steroid hormone fractions estrone (versus A1/A1 genotype: +10.9%; P = 0.05) and es

287 Estrone was detected in all of the samples and 17beta-es

288 No significant increase in circulating estrone was detected in either group.

289 17 alpha-Estradiol was less effective, and estrone was devoid of vasorelaxing activity.

290 Estrone was found to be the greatest contributor to estr

291 n 17alpha-estradiol and 17beta-estradiol via estrone was observed in aqueous solutions in the presenc

292 UGT enzyme activity toward estrone was unchanged 1 day posthepatectomy compared wit

293 ne (EaM), estromustine (EoM), estradiol, and estrone were assessed after weeks 1 and 4 of treatment.

294 Free and halogenated estrone were important transformation products in both a

295 D, sex hormone binding globulin, leptin, and estrone were measured at baseline and at week 25.

296 Measurable levels of estradiol and estrone were observed in the serum and uterus of ovariec

297 ven targeted steroids, 17alpha-estradiol and estrone were the most commonly detected, identified in o

298 ved from the A-rings of 17beta-estradiol and estrone were utilized to further compare these reactions

299 products (eugenol, menthol, cholesterol, and estrone) were labeled in a simple fashion.

300 tions were most important below the pK(a) of estrone, whereas charge repulsion between estrone and ne