ライフサイエンスコーパス: eukaryote

1 racellular matrix of the organelles (only in eukaryotes).

2 red additional functional features in higher eukaryotes).

3 interaction network, or interactome, of any eukaryote.

4 ocalization of the origins of replication in eukaryotes.

5 oral and functional specialization in higher eukaryotes.

6 me packaging by nucleosomes is a hallmark of eukaryotes.

7 ion loop motif, unlike DYRK kinases in other eukaryotes.

8 ctural components of the chromatin of higher eukaryotes.

9 Mitochondria are essential organelles in eukaryotes.

10 ssful in colonizing new habitats compared to eukaryotes.

11 back to before the diversification of modern eukaryotes.

12 rotein family found in archaea, bacteria and eukaryotes.

13 animal taxa, and absent from photosynthetic eukaryotes.

14 lamine are two major phospholipid classes in eukaryotes.

15 me (SPL) is a hallmark of gene regulation in eukaryotes.

16 ike metabolite found in both prokaryotes and eukaryotes.

17 ls cell proliferation and differentiation in eukaryotes.

18 bacteria and yeast, less is known in higher eukaryotes.

19 zymes for catalysis of mRNA deadenylation in eukaryotes.

20 f dynamic cellular processes in bacteria and eukaryotes.

21 senescence in yeast, humans, and most other eukaryotes.

22 f regulators mediating gene silencing across eukaryotes.

23 n is an essential signaling mechanism within eukaryotes.

24 or identifying active regulatory elements in eukaryotes.

25 hallmark mechanism of TOR regulation across eukaryotes.

26 gulation of complex biochemical reactions in eukaryotes.

27 ructures extending from the core ribosome in eukaryotes.

28 ptor (SNARE)-mediated membrane fusion in all eukaryotes.

29 (NTA) is a prevalent protein modification in eukaryotes.

30 inant of cellular growth and lifespan across eukaryotes.

31 signals to coordinate cellular decisions in eukaryotes.

32 established during early development in many eukaryotes.

33 d are involved in many cellular processes in eukaryotes.

34 s essential regulated protein degradation in eukaryotes.

35 riched near transcription start sites in all eukaryotes.

36 uclear remodelling mechanisms across diverse eukaryotes.

37 d yet abundant class of proteins in pro- and eukaryotes.

38 us in marine environments and infect diverse eukaryotes.

39 errogate >3,000 gene families in archaea and eukaryotes.

40 l mechanism of regulation of CMGC kinases in eukaryotes.

41 sociated with increased stress resistance in eukaryotes.

42 nions and are found in prokaryotes and lower eukaryotes.

43 haring most DNA repair mechanisms with other eukaryotes.

44 K spatial regulation may be conserved across eukaryotes.

45 processes by coupling integrated signals in eukaryotes.

46 is now recognized as a conserved feature of eukaryotes.

47 siological function of organisms, especially eukaryotes.

48 modifications of proteins are widespread in eukaryotes.

49 asily implemented, and applicable to several eukaryotes.

50 ates the polyubiquitination of substrates in eukaryotes.

51 ing enzymes of the urea synthesis pathway in eukaryotes.

52 ystems in bacteria and archaea as well as in eukaryotes.

53 hromosome folding mechanisms of bacteria and eukaryotes.

54 (proteostasis) is an essential task for all eukaryotes.

55 me involved in DNA replication and repair in eukaryotes.

56 e physiological function across bacteria and eukaryotes.

57 naling paradigm and reveal its importance in eukaryotes.

58 s derived from back-splicing of genes across eukaryotes.

59 plication of their ligand in prokaryotes and eukaryotes.

60 achieved for models of enhancer function in eukaryotes.

61 enome structure have thwarted HGT studies of eukaryotes.

62 ic asymmetry that is ancestral to all extant eukaryotes.

63 nt of magnetoreception in general, including eukaryotes.

64 ism with nutrient and energy availability in eukaryotes.

65 eply conserved regulator of transcription in eukaryotes.

66 s (if not exceeds) that of the multicellular eukaryotes.

67 roteins and are conserved in prokaryotes and eukaryotes.

68 foundly affects all DNA-related processes in eukaryotes.

69 has provided new insights into the origin of eukaryotes.

70 tory role in mRNA stability and functions in eukaryotes.

71 mation that was already present in ancestral eukaryotes.

72 eral framework derived from studies in other eukaryotes.

73 ism that controls many cellular functions in eukaryotes.

74 nto oxygen-sensing origins and mechanisms in eukaryotes.

75 length and disorder in transcription across eukaryotes.

76 lective constraints present at the origin of eukaryotes.

77 y understood; this also applies to all other eukaryotes.

78 d in untranslated mRNA regions (UTRs) across eukaryotes.

79 organelles, and the extracellular milieu in eukaryotes.

80 drives protein disaggregation in nonmetazoan eukaryotes.

81 ation and generates biousable Cu(1+) ions in eukaryotes.

82 of the major metabolic pathways of arenes in eukaryotes.

83 ochondria are an essential organelle in most eukaryotes.

84 derstanding the evolution of fungi and early eukaryotes.

85 porting and controlling cellular function in eukaryotes.

86 athway for Ca(2+) entry into mitochondria in eukaryotes.

87 ding proteins, is fundamentally important in eukaryotes.

88 sion and suppress mobile genetic elements in eukaryotes(1,2).

89 chromosomes(3-7) and are nearly universal in eukaryotes(8-11).

90 Among eukaryotes, a group of model organisms has been employed

91 tion origins play key roles in ensuring that eukaryotes accurately replicate their genomes.

92 Nucleosomes in eukaryotes act as platforms for the dynamic integration

93 conserved mechanism used by prokaryotes and eukaryotes alike to control cell fate and generate cell

94 ich are used by animal cells and unicellular eukaryotes alike.

95 ntracellular organization in prokaryotes and eukaryotes alike.

96 This feature is conserved across eukaryotes, although its biological significance is unkn

97 cting viruses at all taxonomic ranks of both eukaryote and prokaryote hosts were compiled.

98 -5-methylcytosine separates prokaryotes from eukaryotes and 5-hydroxymethylcytosine (5hmC) invertebra

99 doribonuclease that is well-conserved across eukaryotes and a newly established member of the higher

100 otein p27, a prominent regulatory protein in eukaryotes and an intrinsically disordered protein (IDP)

101 ing similarities between the cell biology of eukaryotes and archaea [10-15].

102 2'-O-rRNA methylation, which is essential in eukaryotes and archaea, is catalysed by the Box C/D RNP

103 Mitochondria are essential in most eukaryotes and are involved in numerous biological funct

104 g RNAs (lncRNAs) have been identified in all eukaryotes and are most abundant in the human genome.

105 nalyses support a close relationship between eukaryotes and Asgard archaea and identify the Heimdalla

106 increasing, though we note that research in eukaryotes and bacteria has largely progressed in isolat

107 This powerful mechanism is conserved across eukaryotes and controls the cellular events that lead to

108 While broadly conserved among eukaryotes and essential for viability in many organisms

109 e key regulators of cellular organization in eukaryotes and genes that tune PI signaling are implicat

110 s into those of their hosts-are prevalent in eukaryotes and have an important role in genome evolutio

111 uce sphingolipids but they are ubiquitous in eukaryotes and have been intensively studied in yeast an

112 Sec14 domain proteins are found only in eukaryotes and have been well characterized in yeast, wh

113 aled that circRNAs are ubiquitously found in eukaryotes and have defined the different biological rol

114 MAGE genes are conserved in all eukaryotes and have expanded from a single gene in lower

115 that have shaped the endomembrane system in eukaryotes and highlights ways in which membrane traffic

116 ological clocks are found broadly throughout eukaryotes and in cyanobacteria, where they generate cir

117 iphosphate (IPP), which is essential in both eukaryotes and prokaryotes for polyisoprenoid synthesis.

118 Protein secretion in eukaryotes and prokaryotes involves a universally conser

119 and a newly established member of the higher eukaryotes and prokaryotes nucleotide-binding (HEPN) dom

120 PHD homologues exist in other types of eukaryotes and prokaryotes where they act on non HIF sub

121 ty is fundamental to the development of both eukaryotes and prokaryotes, yet the mechanisms behind it

122 es have enabled programmable gene editing in eukaryotes and prokaryotes.

123 ificant player in the evolution of microbial eukaryotes and provide examples where HGT has facilitate

124 robic respiration is essential to almost all eukaryotes and sensing oxygen is a key determinant of su

125 Like many eukaryotes and some bacteria, Bacillus subtilis primaril

126 ve molecular definition of these unicellular eukaryotes and their specialized compartments, and these

127 We trace DIX domains to unicellular eukaryotes and thus show that DIX-dependent polymerizati

128 tween bacteria whose ecological niche is the eukaryote, and the eukaryote, is often symbiosis or stas

129 bstantially less noncoding DNA than those of eukaryotes, and as a result, they have much less raw mat

130 tant roles in numerous cellular functions in eukaryotes, and it does so across a functionally diverse

131 entatives of ancestors of the main groups of eukaryotes, and our knowledge of the evolution of chroma

132 coordinated in Sulfolobus, as is the case in eukaryotes, and that two contractile ESCRT-III polymers

133 are unexpectedly widespread in bacteria and eukaryotes, and the contribution of these genes to micro

134 lar vesicles (EVs) is a common feature among eukaryotes, archaea, and bacteria.

135 r is a means by which bacteria, archaea, and eukaryotes are able to trade DNA within and between spec

136 sent from eubacterial genomes, indicate that eukaryotes are capable of improved forms of genetic info

137 Transcription start sites (TSS) in eukaryotes are characterized by a nucleosome-depleted re

138 both similarities and differences with other eukaryotes are emerging.

139 All lipid transport proteins in eukaryotes are thought to shuttle lipids between cellula

140 In many eukaryotes, Argonaute proteins, guided by short RNA sequ

141 nly by prokaryotes yet is widely required by eukaryotes as an enzyme cofactor.

142 regulators that are highly conserved across eukaryotes as well as those that are fungal-specific.

143 n not unique to plants, but present in other eukaryotes as well.

144 ikely to apply to related proteins in higher eukaryotes as well.

145 ) sterols of chlorophyte algae, the dominant eukaryotes at that time.

146 been more widely used with prokaryotes than eukaryotes, because the method is thought to require man

147 e not thought to have crossed the prokaryote-eukaryote boundary.

148 mbers of protein families are present across eukaryotes but have been lost in humans.

149 l tool for characterizing gene expression in eukaryotes, but current methods are incompatible with ba

150 c environment is not unique to single-celled eukaryotes, but has also evolved in a multicellular, par

151 regulatory machinery is highly conserved in eukaryotes, but how these multiple protein kinases, prot

152 yclin types, cyclin A and B, exist in higher eukaryotes, but their specialised functions in mitosis a

153 a disease, uses the T6SS to evade phagocytic eukaryotes, cause intestinal inflammation, and compete a

154 the ancestral eukaryotic lifeforms, general eukaryote cell biology, protein diversification and the

155 biquitously expressed homologous proteins in eukaryote cells, playing a critical role in mitochondria

156 onserved across species from the unicellular eukaryote Chlamydomonas to humans.

157 anscriptional regulation in bacteria, but in eukaryotes, chromatin accessibility and energy expenditu

158 RNA Polymerase II is highly conserved among eukaryotes ("classic model").

159 me categories were also tested for microbial eukaryote communities (18S rRNA), and (5) developmental

160 We find that eukaryotes consistently originate from within the archae

161 Microbial eukaryotes constitute a significant fraction of biodiver

162 All eukaryotes contain the accessory helicase Pif1, which tr

163 The circadian clock in eukaryotes controls transcriptional and posttranscriptio

164 In eukaryotes, DNA polymerase delta (Pol delta) bound to th

165 In eukaryotes, DNA wraps around histones to form nucleosome

166 This poses a challenge for eukaryotes due to their complex mechanisms of transcript

167 Eukaryotes evolved a sophisticated trafficking system wh

168 Eukaryotes express at least three nuclear DNA-dependent

169 itosis has been studied in a wide variety of eukaryotes for more than a century(4), but how the doubl

170 ort that a novel Dolichomastix alga-the only eukaryote found in this system-was the most active commu

171 These changes released eukaryotes from the bioenergetic constraints on prokaryo

172 ade-off across a wide range of heterotrophic eukaryotes from unicellular nanoflagellates to large mam

173 inetoplastid parasite Leishmania Unlike most eukaryotes, gene expression in kinetoplastids is predomi

174 In eukaryotes, gene expression is performed by three RNA po

175 ts are diverse at both the genus (155 of 281 eukaryote genera) and family (120) levels, but comprise

176 recombines genetic variation and influences eukaryote genome evolution.

177 nments to enable the identification of novel eukaryote genomes, including one from the human skin.

178 stone variants expand chromatin functions in eukaryote genomes.

179 understanding of actin-driven phenotypes in eukaryotes has come from the "yeast-to-human" opisthokon

180 epeats (CRISPR) system for genome editing in eukaryotes has revolutionized basic biomedical research

181 ), an enzyme ubiquitous and essential in all eukaryotes, has been validated via genetic and pharmacol

182 siae protein Ddi1 and its homologs in higher eukaryotes have been proposed to serve as shuttling fact

183 Higher eukaryotes have evolved elegant and redundant pathways t

184 Eukaryotes have multiple translocon quality control (TQC

185 Recent studies in bacteria and eukaryotes have revealed the functions of evolutionarily

186 Most aerobic organisms, including nearly all eukaryotes, have class I RNRs consisting of R1 and R2 su

187 In eukaryotes, heterochromatin is generally located at the

188 In eukaryotes, HSF1 is the master regulator of the heat sho

189 sence has also been reported in bacteria and eukaryotes (human and mouse).

190 rgely conserved across the vast diversity of eukaryotes, implying both ancient organization and funct

191 of membrane trafficking might well occur in eukaryotes in general.

192 VEN4 homologs are present in a wide range of eukaryotes including humans, where the corresponding hom

193 ed in virtually every biological function in eukaryotes, including cellular differentiation and respo

194 -loops are common in the genomes of pro- and eukaryotes, including humans, and may play an important

195 erse biological functions in prokaryotes and eukaryotes, including neurotransmission in vertebrates.

196 in prokaryotes, archaea and a wide range of eukaryotes, including yeasts and mammalian cells.

197 eric G proteins, two major signaling hubs in eukaryotes, independently relay signals across the plasm

198 In eukaryotes, initiation is sophisticated, requiring dozen

199 Cell identity in eukaryotes is controlled by transcriptional regulatory n

200 Cytokinesis in many eukaryotes is dependent on a contractile actomyosin ring

201 Detecting and describing HGT events in eukaryotes is difficult, making this phenomenon at times

202 The greater complexity of eukaryotes is linked with larger genomes and we demonstr

203 capacity for rapid Na(+)-based signaling in eukaryotes is not restricted to animals or to the presen

204 are specified at individual promoters across eukaryotes is not understood for most species.

205 Nucleotide excision repair (NER) in eukaryotes is orchestrated by the core form of the gener

206 Genomic DNA in eukaryotes is organized into chromatin through associati

207 One of the key processes in eukaryotes is RNA splicing, which readies mRNA for trans

208 e ecological niche is the eukaryote, and the eukaryote, is often symbiosis or stasis.

209 e most successful-to the disadvantage of the eukaryote-is the small (less than 1 mum diameter) and ne

210 anisms underlying morphogenesis are known in eukaryotes, it is often difficult to manipulate them in

211 iring and crossover recombination in diverse eukaryotes, it is unknown how individual components asse

212 In most eukaryotes, kinetochore assembly is primed by the histon

213 Diatoms are among the few eukaryotes known to store nitrate (NO(3) (-) ) and to us

214 siae and some other budding yeasts, but most eukaryotes lack sequence-specific origins.

215 igote small surface antigen (gTSSA-I) in the eukaryote Leishmania tarentolae, to allow realistic glyc

216 Given that fungi are eukaryotes like their human host, the number of unique m

217 the deep evolutionary conservation of CK1 in eukaryotes, little is known about its regulation and the

218 nd numerous discoveries of major lineages of eukaryotes, mostly free-living heterotrophic protists.

219 and experimental phenotypic variation in all Eukaryotes-mostly animals, plants and yeasts.

220 As in other eukaryotes, N (6)-methylation of adenosine is the most a

221 ters of the Chloride Channel (CLC) family in eukaryotes: not only controlling the intraorganelle lume

222 RNA splicing and spliceosome assembly in eukaryotes occur mainly during transcription.

223 ting steps are much less complicated than in eukaryotes or archaea.

224 information on the order of events by which eukaryotes originated.

225 Vigorous ongoing debate about eukaryote origins is based on assertions that the topolo

226 olution of phytochromes and the evolution of eukaryotes; phytochrome evolution is thus not a solved p

227 Compared to other eukaryotes, plants harbor multiple copies of these JDPs,

228 molecular chaperone Hsp90, essential in all eukaryotes, plays a multifaceted role in promoting survi

229 In eukaryotes, polyadenylation (poly(A)) is an essential pr

230 In eukaryotes, polyprenols and dolichols are synthesized as

231 ersity of Hsp90 sequences observed in extant eukaryotes preferentially contains variants that support

232 In bacteria, archaea, and eukaryotes PRF is used to downregulate protein productio

233 Translation of most cellular mRNAs in eukaryotes proceeds through a cap-dependent pathway, whe

234 In essentially all eukaryotes, proteins can be modified by the attachment o

235 ies of the wetland mesocosms, especially for eukaryotes (protists, fungi, and algae).

236 ominates the evolution of most multicellular eukaryotes provides ample material for functional innova

237 ese complexes recognize and process Z-DNA in eukaryotes, representing a mechanism of Z-DNA-induced ge

238 All eukaryotes require iron.

239 All eukaryotes require this essential, strictly conserved te

240 Efficient double-strand break repair in eukaryotes requires manipulation of chromatin structure.

241 Gene regulation in eukaryotes requires the controlled access of sequence-sp

242 Gene expression in eukaryotes requires the effective separation of nuclear

243 Cell division in eukaryotes requires the regulated assembly of the spindl

244 on, the primary source of cellular energy in eukaryotes, requires gene products encoded in both the n

245 In eukaryotes, respiration occurs via the mitochondrial ele

246 io of increasing Atlantic influence, but the eukaryote response is more complex.

247 In eukaryotes, RNA Polymerase (Pol) III is specialized for

248 In eukaryotes, RNA polymerase II (RNApII) transcribes messe

249 lated, indicating that, in contrast to other eukaryotes, RPB1 phosphorylation is not a prerequisite f

250 Here, we use the model eukaryote Saccharomyces cerevisiae to show that exposure

251 Genetic circuit design automation for eukaryotes simplifies the construction of regulatory net

252 This eukaryote-specific appended domain also plays a critical

253 Importantly, we found that the eukaryote-specific host signaling molecule inositol hexa

254 In eukaryotes, Spt5 forms a complex with Spt4 and regulates

255 Research on eukaryotes such as animals, plants, oomycetes and fungi

256 For sessile eukaryotes such as plants, integrating such information

257 In eukaryotes, such a function was attributed to suppressor

258 tly shown to be partially conserved in other eukaryotes, such as higher plants.

259 which harbor close phylogenetic ties to the eukaryotes, supports the idea that a critical endosymbio

260 , a conserved Snf2-like protein found in all eukaryotes, switches the search from the diffusion-based

261 ns seem to be more strongly conserved across eukaryotes than are well-characterized functions such as

262 aea are far more closely related to those of eukaryotes than to those of their prokaryotic cousins, t

263 s) are important membrane proteins in higher eukaryotes that carry out a vast array of cellular signa

264 a conserved RNA-binding protein found across eukaryotes that has been suggested to regulate collagen

265 of fast Na(+)-based electrical signaling in eukaryotes that likely contribute to sophisticated cellu

266 esent a highly conserved signaling module in eukaryotes that regulates diverse cellular processes suc

267 ion-coupled quality control mechanism in all eukaryotes that regulates the expression of a significan

268 Among these microbes are many unicellular eukaryotes that span the diversity of the eukaryotic tre

269 In nonmetazoan eukaryotes, the AAA+ disaggregase Hsp78 resolubilizes an

270 In eukaryotes, the CCA is added post-transcriptionally by t

271 In eukaryotes, the DXO/Rai1 enzymes can eliminate most of t

272 In eukaryotes, the DXO/Rai1 family of enzymes removes numer

273 tood at the molecular level in multicellular eukaryotes, the elucidation of similar processes in bact

274 In eukaryotes, the GTPase eIF5B collaborates in the correct

275 In eukaryotes, the majority of membrane proteins are insert

276 their importance for ciliary motility across eukaryotes, the molecular function of the RSs is unknown

277 As in other eukaryotes, the Neurospora catalases are the main enzyme

278 In all eukaryotes, the six-subunit origin recognition complex (

279 In many eukaryotes, the small GTPase Rheb functions as a switch

280 In eukaryotes, the stability, organization, and function of

281 Despite the functional conservation across eukaryotes, the TOR complex has evolved specific functio

282 requently used for translation initiation in eukaryotes, their efficiencies are usually low (<10% com

283 Within eukaryotes they mediate protective roles in innate immun

284 This genomic restructuring gave eukaryotes thousands of fold more energy availability pe

285 ms that enable diatoms and other unicellular eukaryotes to nurture specific microbiomes by fostering

286 nd have expanded from a single gene in lower eukaryotes to ~40 genes in humans and mice.

287 gnaling pathway, not previously described in eukaryotes, to sense and respond to the critical macronu

288 onally distinct TIM complexes, found in most eukaryotes, to the single bifunctional TIM complex prese

289 For 15 years, the eukaryote Tree of Life (eToL) has been divided into five

290 In archaea and eukaryotes, tRNA intron removal is catalyzed by the tRNA

291 In eukaryotes, tRNAs are transcribed in the nucleus and sub

292 -host interactions in bacteria, archaea, and eukaryotes unveiled by cellular electron cryo-tomography

293 their microbial consortia, similar to higher eukaryotes, using unique secondary metabolites that regu

294 Higher eukaryotes utilize Spt4-Spt5 (DSIF) to regulate promoter

295 ly been found in some bacteria and microbial eukaryotes, where their biological functions are largely

296 fications are signatures of "self" in higher eukaryotes, whereas unmodified cap0-RNA is recognized as

297 protein (mRNP) granules conserved throughout eukaryotes which are implicated in the repression, stora

298 r of the transcription factor Nrf1 in higher eukaryotes, which results in the up-regulation of protea

299 The loss of peroxisomes in eukaryotes with reduced mitochondria is thus not unexpec

300 s poorly characterized, especially in higher eukaryotes, with the major product(s), metabolic roles,