ライフサイエンスコーパス: eukaryotic

1 ts and regulates expression of a core set of eukaryotic 5'TOP mRNAs, as well as new, plant-specific 5

2 onnects the N- and C-terminal halves in many eukaryotic ABC transporters, allowing all four consensus

3 ence motif-via the ectopic overexpression of eukaryotic acetyltransferase complexes.

4 ibacter and Oceanicaulis likely implied that eukaryotic algae and other phototrophs could be the prim

5 For eukaryotic algae, a combination of molecular, genetic an

6 In most eukaryotic algae, Rubisco aggregates within a microcompa

7 this protein superfamily in the last common eukaryotic ancestor.

8 rious cellular activity system that has both eukaryotic and archaea homologs.

9 oteome, we highlight recent advances in both eukaryotic and bacterial cells.

10 lize features similar to those found in both eukaryotic and bacterial chromatin to organize their DNA

11 Rs of inositol-containing glycoconjugates in eukaryotic and mycobacterial systems.

12 Extracellular vesicles (EVs) secreted by eukaryotic and prokaryotic cells to transport lipids, pr

13 Fiber proteins are commonly found in eukaryotic and prokaryotic viruses, where they play impo

14 , the functionally similar bacterial Gre and eukaryotic/archaeal TFIIS/TFS.

15 erminal domain of TaiP exposes a mimic of an eukaryotic ATG16L1-binding motif that binds to ATG16L1's

16 ide insight into the assembly specificity of eukaryotic C/D RNPs.

17 new tool in the characterization of complex eukaryotic carbohydrate-degrading systems and in the hig

18 le for an observed activity within a complex eukaryotic catabolic system remains one of the most sign

19 Although several bacterial and eukaryotic CCDs have been characterized, the long-standi

20 e important not only to the understanding of eukaryotic cell biology and metabolism, but also to agri

21 played critical roles in working out how the eukaryotic cell cycle operates and is controlled.

22 During interphase of the eukaryotic cell cycle, the microtubule (MT) cytoskeleton

23 east to establish the basic mechanism of the eukaryotic cell division cycle.

24 During eukaryotic cell division, cyclin-specific docking motifs

25 llular compartmentalisation is necessary for eukaryotic cell function.

26 a(2+)](i) are key for regulation of numerous eukaryotic cell functions.

27 mimic of a crowded cellular environment and eukaryotic cell lysates, that parameters optimized towar

28 Cholesterol is an integral component of eukaryotic cell membranes and a key molecule in controll

29 The two most prevalent forms of eukaryotic cell motility are flagellar-dependent swimmin

30 io-temporal organization of chromatin in the eukaryotic cell nucleus is of vital importance for trans

31 tin cytoskeleton plays a variety of roles in eukaryotic cell physiology, ranging from cell polarity a

32 Several eukaryotic cell signaling pathways are differentially ex

33 domains and have a multitude of functions in eukaryotic cell signaling.

34 hosphatidylinositol (PI) cycle is central to eukaryotic cell signaling.

35 ed organelles present on the surface of many eukaryotic cell types and can be motile or non-motile pr

36 pically an order of magnitude smaller than a eukaryotic cell, and identifies gaps in our current know

37 CDK pair fills the functional space of other eukaryotic cell-cycle kinases controlling DNA replicatio

38 ago and became endosymbionts within the host eukaryotic cell.

39 y independent effector domains into a target eukaryotic cell.

40 of the serine/threonine dephosphorylation in eukaryotic cells and achieve substrate selectivity and s

41 eling inositol-containing glycoconjugates in eukaryotic cells and potentially in mycobacteria, but th

42 ER) is the main site of protein synthesis in eukaryotic cells and requires a high concentration of lu

43 onucleoprotein (RNP) assemblies that form in eukaryotic cells as a result of limited translation in r

44 plays a critical role in the architecture of eukaryotic cells by driving the remodeling and severing

45 structural changes experienced by genomes of eukaryotic cells can be dramatic and spans several order

46 Many eukaryotic cells distribute their intracellular componen

47 Eukaryotic cells have divided the steps of gene expressi

48 must be broken before cells can divide, and eukaryotic cells have evolved multiple ways in which to

49 integrated stress response, which occurs in eukaryotic cells in response to accumulation of unfolded

50 f DNA extracted from diverse prokaryotic and eukaryotic cells in tau misfolding and aggregation.

51 The nucleus in eukaryotic cells is a crowded environment that consists

52 The plasma membrane of eukaryotic cells is asymmetric with respect to its phosp

53 The nuclear morphology of eukaryotic cells is determined by the interplay between

54 The interior of eukaryotic cells is mysterious.

55 Eukaryotic cells migrate by coupling the intracellular f

56 Eukaryotic cells must accurately monitor the integrity o

57 Our results help explain why eukaryotic cells possess multiple resection nucleases.

58 Eukaryotic cells regulate 5'-triphosphorylated RNAs (ppp

59 l focus on developmental processes that give eukaryotic cells their complex structures, with a focus

60 The adaptation of eukaryotic cells to anaerobic conditions is reflected by

61 During division, eukaryotic cells undergo a dramatic, complex and coordin

62 They target eukaryotic cells using different mechanisms, but all req

63 ned by sub-tomogram averaging from nuclei of eukaryotic cells, achieved by cryo-electron tomography (

64 a, organelles protruding from the surface of eukaryotic cells, act as cellular antennae to detect and

65 ictating the spatio-temporal organisation of eukaryotic cells, and in particular the mechanisms contr

66 e transport of cargoes along microtubules in eukaryotic cells, including organelles, mRNA and viruses

67 In eukaryotic cells, proteome remodeling is mediated by the

68 In eukaryotic cells, the N-terminal amino moiety of many pr

69 In eukaryotic cells, the transport of cellular mRNAs to mem

70 While predominantly used to interface eukaryotic cells, there is growing interest in nonanimal

71 In eukaryotic cells, with the exception of the specialized

72 ence of RNA G-quadruplex formation in living eukaryotic cells.

73 ions, controlling virtually every process in eukaryotic cells.

74 cal for the development and function of many eukaryotic cells.

75 m regulated by heat shock factor 1 (Hsf1) in eukaryotic cells.

76 Mitochondria are signaling hubs in eukaryotic cells.

77 canonical pathway for protein degradation in eukaryotic cells.

78 ional formation of LDs into the cytoplasm in eukaryotic cells.

79 tenance of the asymmetric plasma membrane of eukaryotic cells.

80 r rapidly when used to manipulate genomes in eukaryotic cells.

81 s and targets a translation step specific to eukaryotic cells.

82 plays important roles in both bacterial and eukaryotic cells.

83 of its precursor polyprenol, are unusual in eukaryotic cells.

84 tory lipids that direct membrane function in eukaryotic cells.

85 secondary messengers used by prokaryotic and eukaryotic cells.

86 ived lipid bilayers secreted by bacteria and eukaryotic cells.

87 nce for RNA G-quadruplex formation in living eukaryotic cells.

88 eaflet of the plasma membrane of the healthy eukaryotic cells.

89 he rate-limiting step of mRNA degradation in eukaryotic cells.

90 d-directed transport and is indispensable to eukaryotic cells.

91 mes and yield insights into the evolution of eukaryotic chromosome conformation.

92 The nonrandom radial organization of eukaryotic chromosome territories (CTs) inside the nucle

93 requiring organization and restructuring of eukaryotic chromosomes in interphase and during mitosis.

94 eads repressive histone methylation marks on eukaryotic chromosomes.

95 RFC:PCNA crystal structure, suggesting that eukaryotic clamp loaders adopt a similar autoinhibited s

96 complexes, including prokaryotic condensin, eukaryotic cohesin, and eukaryotic condensin.

97 e absence of fertilization, fungal and total eukaryotic community compositions exposed to nanopestici

98 How mitochondria shaped the evolution of eukaryotic complexity has been controversial for decades

99 okaryotic condensin, eukaryotic cohesin, and eukaryotic condensin.

100 Mononegavirales mimic RNA synthesis of their eukaryotic counterparts by utilizing multifunctional RNA

101 to hundreds of nanometers in size, crowd the eukaryotic cytoplasm.

102 CPSFL1 appears to be an example of a eukaryotic cytosolic protein that has been coopted for a

103 re sensory organelles that are essential for eukaryotic development and health.

104 osphorylation sites are hyperabundant in the eukaryotic disordered proteome, suggesting that conforma

105 These observations impact our view of eukaryotic diversity and offer future challenges for cel

106 ted to a few species, which do not represent eukaryotic diversity or environmentally relevant taxa.

107 During translesion synthesis, eukaryotic DNA polymerase zeta (zeta) carries out extens

108 In eukaryotic DNA replication, DNA polymerase epsilon (Pole

109 tiple molecular insights into a key event of eukaryotic DNA replication.

110 proaches to remove contamination and resolve eukaryotic draft genomes from SCG metagenomes, finding s

111 r-Tyr kinase activity is also observed for a eukaryotic dual-specificity Tyr phosphorylation-regulate

112 Here we show that, when acetylated, eukaryotic elongation factor 1A1 (eEF1A1) negatively reg

113 rther, AD-associated hyperphosphorylation of eukaryotic elongation factor 2 (eEF2) was blunted with s

114 in the 40S beak, two binding regions of the eukaryotic elongation factor eEF2.

115 e, cryo-electron microscopy structure of the eukaryotic EMC.

116 The eukaryotic endomembrane system is controlled by small GT

117 Nocturnin (NOCT) is a eukaryotic enzyme that belongs to a superfamily of exori

118 aminase domain, whose sequence is present in eukaryotic enzymes but absent in the E. coli homolog.

119 wn whether they are a prominent component of eukaryotic EVEs.

120 he emerging understanding of early events in eukaryotic evolution to generate a coherent picture.

121 arkably variable in sequence and size across eukaryotic evolution with largely unknown functions.

122 ilaments with high affinity, comparable with eukaryotic F-actin-bundling proteins, such as fimbrin.

123 olutionary and functional relationship among eukaryotic FAAH orthologs and features that contribute t

124 This indicates that these core eukaryotic features are not ubiquitous among animals.

125 r contents, analogous to the triton model in eukaryotic flagella and gliding Mycoplasma We observed h

126 pporting a single evolutionary origin of the eukaryotic flagellum, an origin that dates back to befor

127 ngle RNA molecules in living cells to define eukaryotic functional organization and dynamic processes

128 Eukaryotic gene expression is regulated not only by geno

129 Eukaryotic gene expression regulation involves thousands

130 Eukaryotic gene expression relies on extensive crosstalk

131 gene duplications roughly doubled the proto-eukaryotic gene repertoire, with families inherited from

132 Approximately 25% of eukaryotic genes code for integral membrane proteins tha

133 as system offers a programmable platform for eukaryotic genome and epigenome editing.

134 tase (ATPase) machine, cohesin organizes the eukaryotic genome by extruding DNA loops and mediates si

135 During interphase, the eukaryotic genome is organized into chromosome territori

136 both bona fide TE integration preferences in eukaryotic genomes and by selection following integratio

137 e the largest group of membrane receptors in eukaryotic genomes and collectively they regulate nearly

138 lements (TEs) are a significant component of eukaryotic genomes and play essential roles in genome ev

139 tion of the repetitive sequence landscape of eukaryotic genomes and that population-level resequencin

140 Eukaryotic genomes are organized within the nucleus thro

141 (LTR) retroelements, which are widespread in eukaryotic genomes but recalcitrant to automated identif

142 However, eukaryotic genomes exhibit vastly greater complexity, wh

143 editing have transformed the manipulation of eukaryotic genomes for potential therapeutic application

144 The evolution of eukaryotic genomes has been propelled by a series of gen

145 The extant distributions of TEs in eukaryotic genomes have been shaped by both bona fide TE

146 covery of high-quality metagenomic assembled eukaryotic genomes is limited by the current availabilit

147 data support a model in which STR length in eukaryotic genomes results from a balance between expans

148 ssential for temporal and spatial control of eukaryotic genomes.

149 on of reference-quality assemblies for large eukaryotic genomes.

150 ession of a substantial fraction of genes in eukaryotic genomes.

151 n the expression, repair, and segregation of eukaryotic genomes.

152 These are the first structures of any eukaryotic GGT with the cysteinylglycine region of the s

153 The discovery of eukaryotic giant viruses has transformed our understandi

154 The synthesis of eukaryotic glycans - branched sugar oligomers attached t

155 gulatory mechanism for SthK, and potentially eukaryotic HCN channels.

156 es ClpB and DnaK, homologs of the respective eukaryotic heat shock proteins Hsp104 and Hsp70, are ess

157 Eukaryotic histone deacetylation, critical for maintaini

158 Eukaryotic histone H3-H4 tetramers contain a putative co

159 However, how RqcH and its eukaryotic homologs (Rqc2 and NEMF), despite their relat

160 al role in mediating interactions with their eukaryotic host are unclear.

161 transfer connected viral lineages to diverse eukaryotic hosts.

162 ncovered therapeutic genetic variation among eukaryotic Hsp104 homologs that specifically antagonized

163 tor, as well as other types of bacterial and eukaryotic immune systems.

164 protein synthesis via phosphorylation of the eukaryotic initiation factor (eIF) 2alpha and thereby in

165 pt dedicated stress kinases to phosphorylate eukaryotic initiation factor 2 (eIF2).

166 However, Abeta-induced inactivation of the eukaryotic initiation factor 2alpha decreases the synapt

167 ely, genetically reducing phosphorylation of eukaryotic initiation factor 2alpha in excitatory neuron

168 bles rapid and reversible phosphorylation of eukaryotic initiation factor 2alpha, leading to inhibiti

169 ystem caused by mutations in subunits of the eukaryotic initiation factor 2B complex (eIF2B).

170 Eukaryotic initiation factor 4A (eIF4A), an ATP-dependen

171 initiation factors involved in 40S scanning (eukaryotic initiation factor 4A [eIF4A], eIF4B, and Ded1

172 atalysis and inhibition for SRD5A2 and other eukaryotic integral membrane steroid reductases remain e

173 s functions for triuret hydrolase in certain eukaryotic intermediary processes and prokaryotic interm

174 by surviving phagocytosis and exploiting the eukaryotic intracellular environment.

175 l components required for membrane fusion in eukaryotic intracellular membrane trafficking pathways.

176 Many eukaryotic intracellular processes employ protein ubiqui

177 The tremendous diversity in eukaryotic life forms can ultimately be traced back to e

178 e little, if any, effect on the evolution of eukaryotic life forms.

179 a microtubule-mediated process essential to eukaryotic life.

180 tivities depend upon PASTA-domain containing eukaryotic-like serine/threonine protein kinases (PASTA-

181 es of NCLDV families correlate with specific eukaryotic lineages, including many photosynthetic group

182 nction, previous work identified that select eukaryotic lineages, including several insects, have los

183 s of EPR-1 are present in a diverse array of eukaryotic lineages, suggesting an ancestral EPR-1 was a

184 at fungi followed a different route to other eukaryotic lineages.

185 in, and related K(+) channels are located in eukaryotic membranes rich in cholesterol.

186 (PI) is an essential structural component of eukaryotic membranes that also serves as the common prec

187 Although eukaryotic messenger RNAs (mRNAs) normally possess a 5'

188 rate across phytoplankton (Cyanobacteria and eukaryotic microalgae) and prokaryotes (bacteria and arc

189 Most eukaryotic microbial diversity is uncultivated, under-st

190 We find these genes in all eukaryotic microorganisms that have structural cell wall

191 ibrant, diverse ecosystem of prokaryotic and eukaryotic microorganisms.

192 4)C methylation on prokaryotic ribosomes and eukaryotic mitochondrial ribosomes.

193 ic gene structure (operons and polarity) and eukaryotic molecular homology (general transcription app

194 Cytoplasmic dynein is a eukaryotic motor protein complex that, along with its re

195 ce assay for protein interaction kinetics on eukaryotic mRNA populations obtained from cells.

196 d rRNA and has recently been investigated in eukaryotic mRNA(1-3).

197 5' Cap structures are ubiquitous on eukaryotic mRNAs, essential for post-transcriptional pro

198 Oxygen-sensing mechanisms of eukaryotic multicellular organisms coordinate hypoxic ce

199 Here, we report a unique class of eukaryotic Na(+)-selective, single-domain channels (EukC

200 These results suggest that, in eukaryotic Na(V) channels, the S4-S5(L) of DI, DII and D

201 tion of DNA unwinding and damage incision in eukaryotic NER.

202 In primary transcripts of eukaryotic nuclear genes, coding sequences are often int

203 te for the closest archaeal relatives of the eukaryotic nuclear lineage.

204 We used eukaryotic, nutrient-limited growth media in a compound

205 te of translation initiation in bacteria and eukaryotic organelles such as mitochondria.

206 solated from various bacterial, archaeal, or eukaryotic organisms and have been evaluated for their a

207 plants to exchange small RNAs with invading eukaryotic organisms can be exploited to provide disease

208 Genomes across a wide range of eukaryotic organisms fold into higher-order chromatin do

209 Survival of eukaryotic organisms in the face of such challenge requi

210 however, highly diverse and pervasive among eukaryotic organisms, which we hypothesize may confound

211 en identified in bacteria, yeasts, and other eukaryotic organisms.

212 is an essential gene-regulation mechanism in eukaryotic organisms.

213 r to provide flexibility and adaptability to eukaryotic organisms.

214 tion factor is known as Spt5 in archaeal and eukaryotic organisms.

215 e primary plastid, while the outermost is of eukaryotic origin.

216 quence motifs conserved across bacterial and eukaryotic orthologs modulate the function of LpThi5.

217 arasite Plasmodium falciparum, a unicellular eukaryotic pathogen, little is known about the predomina

218 echanisms from the plant host to filamentous eukaryotic pathogens, including fungi and Phytophthora s

219 he binding interface between prokaryotic and eukaryotic PC4-like proteins.

220 or proteins to facilitate replication within eukaryotic phagocytes.

221 In eukaryotic photosynthetic organisms, the conversion of s

222 from a largely bacterial to a predominantly eukaryotic phototrophic world, creating the foundation f

223 anistic understanding of N(2)O production in eukaryotic phototrophs and represent an important step t

224 similar structure-function relationships to eukaryotic pLGICs; however, they often encode greater ar

225 Eukaryotic PLMTs are integral membrane enzymes located i

226 During nuclear maturation of most eukaryotic pre-messenger RNAs and long non-coding RNAs,

227 model for studying evolutionarily conserved eukaryotic processes.

228 Tyr residues and phosphorylates a classical eukaryotic protein kinase substrate in vitro This dual T

229 Eukaryotic protein kinases (EPKs) catalyze the transfer

230 nal half of LegK7 is structurally similar to eukaryotic protein kinases, and that MOB1A directly bind

231 In eukaryotic protein N-glycosylation, a series of glycosyl

232 Eukaryotic protein synthesis generally initiates at a st

233 Eukaryotic protein synthesis is an inherently stochastic

234 s variability is tightly controlled: a given eukaryotic protein type is typically associated with a n

235 ogy (YTH) domain, which is commonly found in eukaryotic proteins that bind methylated RNA and is stru

236 growth conditions and the ability of several eukaryotic proteins to sense its presence in the cell cy

237 protein modifications, which occurs on most eukaryotic proteins, but is significantly less common on

238 Unlike eukaryotic proteins, several prokaryotic Argonaute prote

239 o-translationally acetylate the N-termini of eukaryotic proteins.

240 nd protein homeostasis during remodelling of eukaryotic proteomes, and that bioenergetic constraints

241 Eukaryotic replication origins are licensed by the loadi

242 During eukaryotic replication, DNA polymerases epsilon (Polepsi

243 The eukaryotic replicative CMG (Cdc45, Mcm2-7, GINS) helicas

244 ponent of the fork protection complex in the eukaryotic replisome, Timeless, harbours in its C-termin

245 ad aneuploidy signatures previously taken as eukaryotic responses.

246 RNase MRP is an essential eukaryotic ribonucleoprotein complex involved in the mat

247 that possess a less-known function to induce eukaryotic ribosomal readthrough of PTCs to produce a fu

248 and sheds light on a conserved mechanism for eukaryotic ribosome hibernation.

249 n pairs that are efficiently accepted by the eukaryotic ribosome, we took advantage of the IRES from

250 Binding to the decoding site of the eukaryotic ribosomes appears to result in ototoxicity, b

251 Eukaryotic ribosomes in some lineages appear to be logar

252 gut bacterium, Snodgrassella alvi, to induce eukaryotic RNA interference (RNAi) immune responses.

253 Despite being known since the 1970s, eukaryotic RNA modifications were mostly identified on t

254 ce on transcription elongation properties of eukaryotic RNA polymerase I (Pol I) from Saccharomyces c

255 tural homology was found across the range of eukaryotic RNA polymerase II subunits and their associat

256 tructurally, phi14:2 RNAP is most similar to eukaryotic RNAPs that are involved in RNA interference(6

257 larify the transporter activity of essential eukaryotic RND proteins and demonstrate that the two mai

258 (Petrov et al., 2020) provides evidence that eukaryotic RND proteins function as cholesterol transpor

259 The mechanism and driving force for eukaryotic RND proteins, including Dispatched1 and Patch

260 d regulatory mechanism that is widespread in eukaryotic Ser/Thr kinases.

261 drophobic amino acids and a homologue of the eukaryotic SLC6 family of Na(+) -dependent symporters fo

262 Ubiquitylation of the eukaryotic sliding clamp, PCNA, activates a pathway of D

263 Eukaryotic SMC complexes, cohesin, condensin, and Smc5/6

264 comparing the shapes of a prokaryotic and a eukaryotic sodium/proton antiporter homologue.

265 pathways among the hundreds of thousands of eukaryotic species that will become available in the com

266 pe represents the basic genetic make-up of a eukaryotic species.

267 The structure uncovers an unexpected, eukaryotic specific and dynamic fidelity checkpoint impl

268 evolutionarily and chemically related to the eukaryotic spliceosome, with potential applications as g

269 Replication protein A (RPA), a major eukaryotic ssDNA-binding protein, is essential for all m

270 necessary for visualizing cell membranes and eukaryotic subcellular organelles.

271 of transcriptional heterogeneity in diverse eukaryotic systems(1-13), the application of scRNA-seq t

272 to a diverse array of molecular functions in eukaryotic systems.

273 t this interaction may be important in other eukaryotic systems.

274 d yields bursting kinetics characteristic of eukaryotic systems.

275 Empirical evidence from diverse eukaryotic taxa supports the mitonuclear compensatory co

276 gest a process of convergent evolution among eukaryotic TE families.

277 nding of the true potential of the ancestral eukaryotic toolkit.

278 Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology

279 male gametes (sperm cells) are an ancestral eukaryotic trait that has been lost in several lineages

280 Pol II suggests a general mechanism coupling eukaryotic transcription to erasure of the H2A.Z epigene

281 The CTD is crucial to eukaryotic transcription, yet the functional and evoluti

282 amics-an experimentally observed hallmark of eukaryotic transcription.

283 lly responds to specific stimuli to regulate eukaryotic transcriptomes remains unknown.

284 Previous studies have indicated that eukaryotic translation elongation factor 1 delta (eEF1D)

285 (protein kinase R [PKR]) that phosphorylates eukaryotic translation initiation factor 2 alpha (eIF2al

286 require protein kinase R, phosphorylation of eukaryotic translation initiation factor 2 subunit 1 (eI

287 enerated by the reversible polymerization of eukaryotic translation initiation factor 2B, an essentia

288 Eif3b, which encodes a core component of the eukaryotic translation initiation factor 3 (eIF3) comple

289 The eukaryotic translation initiation factor 4E (EIF-4E) pro

290 mobility shift assays (EMSAs) indicated that eukaryotic translation initiation factor 4E (eIF4E) bind

291 Eukaryotic translation initiation factor 4E (eIF4E) bind

292 Here, we discovered that eukaryotic translation initiation factor 4E (eIF4E), its

293 questers the cap, inhibits interactions with eukaryotic translation initiation factor 4E, and resists

294 Additionally, expression levels of eukaryotic translation initiation factor 4GI (eIF4GI) an

295 to cells due to their miscoding capacity in eukaryotic translation systems.

296 Eukaryotic TSEN is comprised of four core subunits (TSEN

297 in 11-13-nucleotide-long oligomers, and the eukaryotic type, which removes the damage in 24-32-nucle

298 esults reveal an inverse association between eukaryotic virome abundance and poliovirus shedding.

299 Non-poliovirus eukaryotic virus abundance (3.68 log(10) vs. 2.25 log(10

300 inary assessment of the genomic diversity of eukaryotic viruses, reinforcing the need for the isolati