ライフサイエンスコーパス: eukaryotic genome

1 tage for completion of a designer, synthetic eukaryotic genome.

2 Copia superfamily, which is present in every eukaryotic genome.

3 riation in initial UV damage levels across a eukaryotic genome.

4 , mutation rates are not uniform across each eukaryotic genome.

5 limited to cover the complexity of the whole eukaryotic genome.

6 rucial role of RNA in the functioning of the eukaryotic genome.

7 nscription factors and RNA polymerase to the eukaryotic genome.

8 ue insight into the cis-regulatory code of a eukaryotic genome.

9 mes are the fundamental packing units of the eukaryotic genome.

10 y role in dictating the accessibility of the eukaryotic genome.

11 heat tolerance in a complete subterrestrial eukaryotic genome.

12 at the center of the faithful duplication of eukaryotic genomes.

13 epeats (LTRs) form a substantial fraction of eukaryotic genomes.

14 , like retroviruses, to copy and move inside eukaryotic genomes.

15 ur ability to engineer targeted mutations in eukaryotic genomes.

16 llite DNA (satDNA) repeats are found in most eukaryotic genomes.

17 ute a large percentage of the DNA content of eukaryotic genomes.

18 rved property of the spatial organization of eukaryotic genomes.

19 elements (TEs) make up a large proportion of eukaryotic genomes.

20 i.e. DNA encoded, nucleosome organization of eukaryotic genomes.

21 at it is an important driver of diversity in eukaryotic genomes.

22 subtelomeric regions, are unstable sites of eukaryotic genomes.

23 eoprotein complex that protects and compacts eukaryotic genomes.

24 parum but should be applicable to many other eukaryotic genomes.

25 ed to identify regions of DNA methylation in eukaryotic genomes.

26 on of reference-quality assemblies for large eukaryotic genomes.

27 a tool for editing, imaging, and regulating eukaryotic genomes.

28 e need to control noncoding transcription in eukaryotic genomes.

29 high-resolution structural understanding of eukaryotic genomes.

30 among the most evolutionary dynamic loci of eukaryotic genomes.

31 ibute to long-term gene content evolution in eukaryotic genomes.

32 s (TEs), which make up between 20 and 80% of eukaryotic genomes.

33 Divergent gene pairs (DGPs) are abundant in eukaryotic genomes.

34 y elements and inferring their activities in eukaryotic genomes.

35 increasing the scale of known viral genes in eukaryotic genomes.

36 sms at the heart of epigenetic regulation of eukaryotic genomes.

37 tion, expression, repair, and segregation of eukaryotic genomes.

38 tein-coding genes and many noncoding RNAs in eukaryotic genomes.

39 l III type 2-like promoters are conserved in eukaryotic genomes.

40 romatin occupy a substantial portion of many eukaryotic genomes.

41 rminants of their abundance and stability in eukaryotic genomes.

42 gene innovations during the evolution of the eukaryotic genomes.

43 ion is essential for accurate duplication of eukaryotic genomes.

44 to precisely classify TEs in newly sequenced eukaryotic genomes.

45 easingly powerful with the growing wealth of eukaryotic genomes.

46 ncy plays a key role in regulating access to eukaryotic genomes.

47 ant roles in the regulation and stability of eukaryotic genomes.

48 eshifts predicted in mRNA sequences from 100 eukaryotic genomes.

49 o the prevalence of these genes within other eukaryotic genomes.

50 the architecture and function of many higher eukaryotic genomes.

51 t are present in millions of copies in large eukaryotic genomes.

52 t affects nearly all DNA-templated events in eukaryotic genomes.

53 anding on: nuclear receptors, stem cells and eukaryotic genomes.

54 significant fraction of proteins encoded in eukaryotic genomes.

55 een regulatory elements and their targets in eukaryotic genomes.

56 form of DNA modification in prokaryotic and eukaryotic genomes.

57 allmark of functional regulatory elements in eukaryotic genomes.

58 ession of a substantial fraction of genes in eukaryotic genomes.

59 We evaluated Look4TRs on 26 eukaryotic genomes.

60 the most common chemically modified base in eukaryotic genomes.

61 tribution to the adaptation and evolution of eukaryotic genomes.

62 infeasible to assay all TFs in all sequenced eukaryotic genomes.

63 n the expression, repair, and segregation of eukaryotic genomes.

64 and account for a prominent fraction of most eukaryotic genomes.

65 (remodellers) regulate DNA accessibility in eukaryotic genomes.

66 pecies- and context-specific distribution in eukaryotic genomes.

67 sine (m6dA), has recently been discovered in eukaryotic genomes.

68 ere will greatly facilitate TE annotation in eukaryotic genomes.

69 t DNA motifs (usually 1 to 6 bp) abundant in eukaryotic genomes.

70 n used to artificially recruit proteins onto eukaryotic genomes.

71 rstanding the organization and regulation of eukaryotic genomes.

72 been widely used to target DNA sequences in eukaryotic genomes.

73 n "families" across multiple prokaryotic and eukaryotic genomes.

74 ansposable elements (MITEs) are prevalent in eukaryotic genomes.

75 ssential for temporal and spatial control of eukaryotic genomes.

76 el for the three-dimensional organization of eukaryotic genomes.

77 imentary mitochondria and the smallest known eukaryotic genomes(5-7).

78 Nucleosomes and chromatin control eukaryotic genome accessibility and thereby regulate DNA

79 Although P5 ATPases are present in every eukaryotic genome analyzed so far, they have remained or

80 as system offers a programmable platform for eukaryotic genome and epigenome editing.

81 programmed to target specific regions of the eukaryotic genome and has become a powerful tool for gen

82 lomeric sequences (ITSs) are present in many eukaryotic genomes and are linked to genome instabilitie

83 Transposons are massively abundant in all eukaryotic genomes and are suppressed by epigenetic sile

84 both bona fide TE integration preferences in eukaryotic genomes and by selection following integratio

85 elements (TEs) are ubiquitous components of eukaryotic genomes and can create variation in genome or

86 e the largest group of membrane receptors in eukaryotic genomes and collectively they regulate nearly

87 discuss how LINEs and SINEs have expanded in eukaryotic genomes and contribute to genome evolution.

88 , are enriched in heterochromatic regions of eukaryotic genomes and contribute to nuclear structure a

89 ve transcription events occurring throughout eukaryotic genomes and coupling their RNA products to ef

90 Copy number variation (CNV) is rife in eukaryotic genomes and has been implicated in many human

91 hromatin represents a significant portion of eukaryotic genomes and has essential structural and regu

92 common modification in prokaryotic and lower eukaryotic genomes and has many biological functions, th

93 elements (TEs) can be found in virtually all eukaryotic genomes and have the potential to produce evo

94 DNA methylation is a common feature of eukaryotic genomes and is especially common in noncoding

95 Cytosine methylation is widespread in most eukaryotic genomes and is known to play a substantial ro

96 from transposons make up a large fraction of eukaryotic genomes and must be silenced to protect genom

97 quivalent junctions are prevalent in diverse eukaryotic genomes and occur in 88.64% and 78.64% of ann

98 long tandem repeats (ETRs) are widespread in eukaryotic genomes and play an important role in fundame

99 lements (TEs) are a significant component of eukaryotic genomes and play essential roles in genome ev

100 ile elements, make up large portions of most eukaryotic genomes and provide enormous, albeit commonly

101 Heterochromatin is a conserved feature of eukaryotic genomes and regulates various cellular proces

102 tion of the repetitive sequence landscape of eukaryotic genomes and that population-level resequencin

103 ed primarily for detecting gene exons within eukaryotic genomes and were therefore optimized for spee

104 osome is the fundamental packing unit of the eukaryotic genome, and CpG methylation is an epigenetic

105 roach provides detailed structural maps of a eukaryotic genome, and our findings provide insights int

106 gramming implementation that scales to large eukaryotic genomes, and a faster indexed based implement

107 ats (STRs) are found in many prokaryotic and eukaryotic genomes, and are commonly used as genetic mar

108 eported to integrate into human or any other eukaryotic genomes, and could thus serve for exploration

109 nhances the diversity of proteins encoded by eukaryotic genomes, and is also important in gene expres

110 Repeated regions are widespread in eukaryotic genomes, and key functional elements such as

111 for assembling high-quality plant and other eukaryotic genomes, and serves as a valuable resource fo

112 ent the single largest component of numerous eukaryotic genomes, and their activity and dispersal con

113 repetitive DNA make up a sizable fraction of Eukaryotic genomes, and their annotation is crucial to t

114 occupy a substantial fraction of nearly all eukaryotic genomes, and they represent a major source of

115 Recent changes to NCBI's eukaryotic genome annotation pipeline provide higher thr

116 Bank currently has automatic prokaryotic and eukaryotic genome annotation pipelines but has no viral

117 ve feature annotation and current policy for eukaryotic genome annotation via the NCBI annotation pip

118 Kinannote has had a significant impact on eukaryotic genome annotation, providing protein kinase a

119 cha trifallax displays an extreme and unique eukaryotic genome architecture with extensive genomic va

120 Despite this, few complete eukaryotic genomes are available, and genome annotation

121 Higher eukaryotic genomes are bound by a large number of coding

122 Eukaryotic genomes are broadly divided between gene-rich

123 Eukaryotic genomes are dynamically regulated through a h

124 Eukaryotic genomes are extensively transcribed, forming

125 Eukaryotic genomes are folded into three-dimensional str

126 Eukaryotic genomes are hierarchically organized into pro

127 Pairs of genes within eukaryotic genomes are often located on opposite DNA str

128 Eukaryotic genomes are organized into chromatin domains

129 Eukaryotic genomes are organized into domains of differi

130 based assays such as Hi-C have revealed that eukaryotic genomes are organized into structural units c

131 Eukaryotic genomes are organized within the nucleus thro

132 Eukaryotic genomes are packaged into an extensively fold

133 All eukaryotic genomes are packaged into basic units of DNA

134 Eukaryotic genomes are pervasively transcribed and only

135 Eukaryotic genomes are pervasively transcribed but until

136 Given that eukaryotic genomes are pervasively transcribed, transcri

137 Eukaryotic genomes are regulated by the diverse biochemi

138 Eukaryotic genomes are repetitively wrapped into nucleos

139 Eukaryotic genomes are replicated from many origin sites

140 Eukaryotic genomes are replicated from multiple DNA repl

141 Eukaryotic genomes are replicated in a reproducible temp

142 Eukaryotic genomes are rich in transcription units encod

143 Eukaryotic genomes are spatially organized within the nu

144 Eukaryotic genomes are transcribed into numerous regulat

145 The majority of eukaryotic genomes are unfinished due to the algorithmic

146 target H1 regulation to specific regions of eukaryotic genomes are unknown.

147 le research tool, but obtaining high quality eukaryotic genome assemblies remains a challenge, mostly

148 Although annotating a eukaryotic genome assembly is now within the reach of no

149 There are now many eukaryotic genomes available, but these are considerably

150 EukCC, a tool for estimating the quality of eukaryotic genomes based on the automated dynamic select

151 shes S. cerevisiae as the basis for designer eukaryotic genome biology.

152 (LTR) retroelements, which are widespread in eukaryotic genomes but recalcitrant to automated identif

153 (lncRNAs) are pervasively transcribed across eukaryotic genomes, but functions of only a very small s

154 thylation is ancient and highly conserved in eukaryotic genomes, but its role has not been clearly de

155 replication initiates at distinct origins in eukaryotic genomes, but the genomic features that define

156 Transposons are highly abundant in eukaryotic genomes, but their mobilization must be finel

157 tase (ATPase) machine, cohesin organizes the eukaryotic genome by extruding DNA loops and mediates si

158 te genome-wide detection of MITEs in various eukaryotic genomes can improve our understanding of thei

159 sed chromatin organization paved the path to eukaryotic genome complexity, a critical hurdle en route

160 Large portions of eukaryotic genomes consist of transposable elements (TEs

161 The eukaryotic genome consists of DNA molecules far longer t

162 To ensure high rRNA level, eukaryotic genomes contain dozens to hundreds of rDNA ge

163 Consequently, highly reduced eukaryotic genomes contain more genes of archaebacterial

164 Eukaryotic genomes contain multiple tubulin isotypes, an

165 Eukaryotic genomes contain numerous non-functional high-

166 Most eukaryotic genomes contain substantial amounts of repeti

167 eosomes, the fundamental organizing units of eukaryotic genomes, contain ~146 base pairs of DNA wrapp

168 bosomes (rRNA), are highly repetitive in all eukaryotic genomes, containing 100s to 1000s of copies,

169 epetitive elements in human and other higher eukaryotic genomes contribute in large part to ambiguous

170 providing new insight into this key stage of eukaryotic genome copying.

171 iew major advances in epigenomic analysis of eukaryotic genomes, covering aspects of genome folding a

172 Analysis of prokaryotic and eukaryotic genome databases established that multiple in

173 The diversity of inputs encountered by eukaryotic genomes demands a matching capacity for trans

174 rrect expression, repair, and segregation of eukaryotic genomes depend on cohesin, ring-shaped protei

175 udio, an open-source framework developed for eukaryotic genome design, which coordinates design modif

176 For eukaryotic genomes, DNA synthesis initiates at multiple

177 Polymerase delta is essential for eukaryotic genome duplication and synthesizes DNA at bot

178 se unwinds DNA during the elongation step of eukaryotic genome duplication and this process depends o

179 Eukaryotic genome duplication relies on origins of repli

180 delta, and Pol epsilon), are responsible for eukaryotic genome duplication.

181 able microbial adaptive immunity and provide eukaryotic genome editing tools.

182 e bacterium (LbCpf1) have been harnessed for eukaryotic genome editing.

183 Many eukaryotic genomes encode cis-natural antisense transcri

184 A third of the genes in prokaryotic and eukaryotic genomes encode membrane proteins that are eit

185 S or SelD), conserved in all prokaryotic and eukaryotic genomes encoding selenoproteins.

186 Type I systems have rarely been used for eukaryotic genome engineering applications owing to the

187 biotic theory posits that bacterial genes in eukaryotic genomes entered the eukaryotic lineage via or

188 Despite the increased size and complexity of eukaryotic genomes, eukaryotic DNA replication continues

189 on (WGD) and diploidization are hallmarks of eukaryotic genome evolution and speciation.

190 y thought, with interesting implications for eukaryotic genome evolution.

191 of genetic variation in populations and how eukaryotic genomes evolve.

192 However, eukaryotic genomes exhibit vastly greater complexity, wh

193 In contrast, several eukaryotic genomes express moderately methylated genes.

194 We describe a survey of unicellular eukaryotic genomes for GRLs, identifying several candida

195 editing have transformed the manipulation of eukaryotic genomes for potential therapeutic application

196 Eukaryotic genomes frequently acquire new protein-coding

197 having abundant simple-sequence repeats for eukaryotic genome function and evolvability.

198 Eukaryotic genomes generate a heterogeneous ensemble of

199 Eukaryotic genomes generate vast numbers of non-protein-

200 Eukaryotic genomes harbor transposable elements and othe

201 expression, but their identification in the eukaryotic genome has been challenging.

202 The eukaryotic genome has vast intergenic regions containing

203 The evolution of eukaryotic genomes has been propelled by a series of gen

204 The order of genes in eukaryotic genomes has generally been assumed to be neut

205 The extant distributions of TEs in eukaryotic genomes have been shaped by both bona fide TE

206 Our results suggest that eukaryotic genomes have developed tools to prevent R-loo

207 nces in the targeted modification of complex eukaryotic genomes have unlocked a new era of genome eng

208 weaknesses of short reads in the assembly of eukaryotic genomes; however, at present additional scaff

209 ve heterochromatin is a prevalent feature of eukaryotic genomes important for promoting cell differen

210 Consequently, the complexity of higher eukaryotic genomes imposes severe limitations on transcr

211 ecoding 4-codon boxes are almost absent from eukaryotic genomes in contrast to bacterial genomes.

212 Plant genomes, and eukaryotic genomes in general, are typically repetitive,

213 on (WGD) is central to the evolution of many eukaryotic genomes, in particular rendering angiosperm (

214 ing DNA sequences are present throughout the eukaryotic genome, including in telomeric DNA.

215 We present methods for the analysis of small eukaryotic genomes, including a streamlined system (call

216 ansposable elements (MITEs) are prevalent in eukaryotic genomes, including plants and animals.

217 al circular DNA (eccDNA) is both a driver of eukaryotic genome instability and a product of programme

218 ng GAA/TTC repeats pose a dual threat to the eukaryotic genome integrity.

219 l DNA sequence are believed to demarcate the eukaryotic genome into distinct structural and functiona

220 The segregation of eukaryotic genomes into euchromatin and heterochromatin

221 in controlling transcription and organizing eukaryotic genomes into functional domains.

222 The eukaryotic genome is highly compacted into a protein-DNA

223 The eukaryotic genome is highly organized in the nucleus, an

224 The eukaryotic genome is organized in the three-dimensional

225 During interphase, the eukaryotic genome is organized into chromosome territori

226 The eukaryotic genome is organized into nucleosomes, the fun

227 The eukaryotic genome is organized within cells as chromatin

228 The eukaryotic genome is primarily replicated by two DNA pol

229 Heterochromatin in the eukaryotic genome is rigorously controlled by the concer

230 The majority of the eukaryotic genome is transcribed, generating a significa

231 Whole-genome sequencing of uncultured eukaryotic genomes is complicated by difficulties in acq

232 Faithful maintenance and propagation of eukaryotic genomes is ensured by three-step DNA ligation

233 Replication of eukaryotic genomes is highly stochastic, making it diffi

234 However, because the k-mer distribution in eukaryotic genomes is highly uneven, minimizer-based too

235 covery of high-quality metagenomic assembled eukaryotic genomes is limited by the current availabilit

236 The spatial organization of eukaryotic genomes is linked to their functions.

237 Gene finding in eukaryotic genomes is notoriously difficult to automate.

238 Assembling complete bacterial and small eukaryotic genomes is now possible, but the final step o

239 hich nucleosome repositioning is used within eukaryotic genomes is poorly understood.

240 and resolution of toxic SCI entanglements on eukaryotic genomes is proposed.

241 The spatial organization of eukaryotic genomes is thought to play an important role

242 A large proportion of eukaryotic genomes is transcribed from both positive and

243 tern has been observed in nucleosomes across eukaryotic genomes, its use for prediction of nucleosome

244 g it one of the smallest and most gene dense eukaryotic genomes known.

245 or influence on shaping both prokaryotic and eukaryotic genomes, largely through stochastic events fo

246 oles in nearly every aspect of bacterial and eukaryotic genome maintenance.

247 -protein coding RNAs are produced throughout eukaryotic genomes, many of which are transcribed antise

248 However, Ths is not encoded in any eukaryotic genomes, nor is it homologous to eukaryotic s

249 Every DNA segment in a eukaryotic genome normally replicates once and only once

250 Epigenetic modifications in eukaryotic genomes occur primarily in the form of 5-meth

251 Eukaryotic genomes often contain large quantities of pot

252 ence of long noncoding RNA (lncRNA) genes in eukaryotic genomes, only a small proportion have been ex

253 Eukaryotic genomes, particularly animal genomes, have a

254 lgorithms used to assemble and analyze large eukaryotic genomes, placed within the historical context

255 Several recent eukaryotic genome projects have reported multiple gene s

256 Recent genome-wide experiments in different eukaryotic genomes provide an unprecedented view of tran

257 st long non-coding RNAs (lncRNAs) encoded by eukaryotic genomes remain uncharacterized.

258 nteraction of transcription factors (TFs) on eukaryotic genomes remains a matter of debate.

259 of conserved replication timing patterns in eukaryotic genomes remains a mystery.

260 With eukaryotic genome replication, incomplete telomere synth

261 )-10(8) incorporations) and support faithful eukaryotic genome replication.

262 The integrity of eukaryotic genomes requires rapid and regulated chromati

263 data support a model in which STR length in eukaryotic genomes results from a balance between expans

264 ymes encoded in a variety of prokaryotic and eukaryotic genomes reveals convergence and divergence at

265 We describe complete design of a synthetic eukaryotic genome, Sc2.0, a highly modified Saccharomyce

266 habditis elegans was the first multicellular eukaryotic genome sequenced to apparent completion.

267 We compared 86 divergent eukaryotic genome sequences to discern sets of proteins

268 Eukaryotic genome sequences, however, increasingly impli

269 tifying LTRs and non-LTR retrotransposons in eukaryotic genome sequences.

270 hance the identification and study of TEs in eukaryotic genome sequences.

271 Eukaryotic genome sequencing and de novo assembly, once

272 Multicellular eukaryotic genomes show enormous differences in size.

273 ovo assembler capable of assembling multiple eukaryotic genomes simultaneously.

274 mputational gene prediction algorithms, most eukaryotic genomes still benefit from manual gene annota

275 esumed to be among the major determinants of eukaryotic genome structure.

276 imilar genes may colocalize (cluster) in the eukaryotic genome, suggesting the role of chromatin-leve

277 dynamic and highly regulated feature of the eukaryotic genome that allows for the essential spatiote

278 l identity are particularly dynamic parts of eukaryotic genomes that are prone to molecular degenerat

279 heterochromatin is an important component of eukaryotic genomes that has essential roles in nuclear a

280 RISPR-Cas9 system is a powerful tool to edit eukaryotic genomes that has recently been adapted for fu

281 We assembled a collection of 172 complete eukaryotic genomes that is not only the largest, but als

282 urrently the only gene finding algorithm for eukaryotic genomes that performs automatic training in u

283 cations comprise a significant proportion of eukaryotic genomes, these findings provide important new

284 In eukaryotic genomes this ubiquitous and highly conserved

285 introns in a given genome, and used it on 24 eukaryotic genomes to create the Intron Annotation and O

286 action might be among natural forces driving eukaryotic genomes to maintain the Zn(2+)-tolerant repet

287 In many eukaryotic genomes, transposable elements (TEs) are wide

288 The promoter regions of active genes in the eukaryotic genome typically contain nucleosomes post-tra

289 sequence availability of about 100 complete eukaryotic genomes, up to now NumtS distribution has bee

290 for collaborative, end-to-end annotation of eukaryotic genomes using UCSC Assembly Hubs and JBrowse/

291 a resulting from recently sequenced complete eukaryotic genomes, we conducted database searching by h

292 karyotes to the quantitative analysis of 216 eukaryotic genomes, we find a strong correlation between

293 By applying these tools to diverse eukaryotic genomes, we provide a ranked list of newly pr

294 vel method for high-throughput sequencing of eukaryotic genomes, we sequenced and assembled 580 Mbp o

295 cterial repertoire has a similar size in all eukaryotic genomes whereas the number of eubacterium-der

296 titive sequences are ubiquitously present in eukaryotic genomes which are in general epigenetically s

297 es, as a source of gene content variation in eukaryotic genomes, which predicts continuous, lineage-s

298 s, exist pervasively in both prokaryotic and eukaryotic genomes, with more than 10,000 copies identif

299 osomes restrict DNA accessibility throughout eukaryotic genomes, with repercussions for replication,

300 As part of the effort to build a designer eukaryotic genome, yeast synthetic chromosome X (synX),