ライフサイエンスコーパス: eukaryotic initiation factor-4E

1 typical for the cap-binding protein known as eukaryotic initiation factor 4E.

2 phorylation of translation initiation factor eukaryotic initiation factor 4E.

3 osphorylate physiological substrates such as eukaryotic initiation factor 4E.

4 slation by targeting the cap-binding protein eukaryotic initiation factor 4E, a key regulator of cell

5 Reduction of eukaryotic initiation factor 4E, a rate-limiting factor

6 Finally, IL-1beta enhanced the expression of eukaryotic initiation factor 4E, a stimulator of LIP exp

7 irways have increased phosphorylation of the eukaryotic initiation factor 4E and its partner the 4E-b

8 tiation factor 4E-binding protein 1 (4E-BP1)/eukaryotic initiation factor 4E and ribosomal p70 S6 kin

9 nt formation of a functional complex between eukaryotic initiation factor-4E and eukaryotic initiatio

10 ts in sequential dissociation of 4E-BP1 from eukaryotic initiation factor-4E and subsequent formation

11 phorylates the translation initiation factor eukaryotic initiation factor-4E and triggers antiapoptot

12 tion factor-4E-binding proteins 1 and 2, and eukaryotic initiation factor-4E, are present in the rat

13 egulation and dephosphorylation of STAT5 and eukaryotic initiation factor 4E as wild-type cells.

14 regulates downstream phosphorylation of the eukaryotic initiation factor 4E at Ser-209.

15 ly depends on transcriptional enhancement of eukaryotic initiation factor 4E binding protein (4E-BP)

16 orylation of two downstream targets of mTOR, eukaryotic initiation factor 4E binding protein 1 (4E-BP

17 Furthermore, Rheb induces phosphorylation of eukaryotic initiation factor 4E binding protein 1 (4E-BP

18 tion of p70 ribosomal S6 kinase (p70s6K) and eukaryotic initiation factor 4E binding protein 1 (4EBP1

19 Thr-308 and Ser-473), S6 kinase 1 (Thr-389), eukaryotic initiation factor 4E binding protein 1 (Thr-3

20 his stress response depends on expression of eukaryotic initiation factor 4E binding protein 1 and is

21 p70 ribosomal protein S6 kinase 1 [S6K1] and eukaryotic initiation factor 4E binding protein 1) and c

22 phosphorylation of pH acid stable protein I (eukaryotic initiation factor 4E binding protein) were ex

23 rylation of both the translational repressor eukaryotic initiation factor 4E binding protein-1 and p7

24 protein synthesis by inhibition of eIF4EBPs (eukaryotic Initiation Factor 4E Binding Proteins), regul

25 p70 ribosomal protein S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E-binding (eIF4E-binding)

26 C1) activation as indicated by a decrease in eukaryotic initiation factor 4E-binding 1 (4E-BP1) phosp

27 through mTOR resulting in phosphorylation of eukaryotic initiation factor 4E-binding protein (4E-BP)1

28 mTORC1 signaling through p70S6Ks (S6K1/2) or eukaryotic initiation factor 4E-binding protein (4E-BP1/

29 , and mLST8, is activated and phosphorylates eukaryotic initiation factor 4E-binding protein (4EBP) a

30 ence of amino acids increased the binding of eukaryotic initiation factor 4E-binding protein (4EBP1)

31 ever, adult HSCs had more hypophosphorylated eukaryotic initiation factor 4E-binding protein 1 (4E-BP

32 et of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP

33 translation through two downstream pathways: eukaryotic initiation factor 4E-binding protein 1 (4E-BP

34 wo translation modulators, p70 S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4E-BP

35 Phosphorylation of the translation repressor eukaryotic initiation factor 4E-binding protein 1 (4E-BP

36 Elevated levels of eukaryotic initiation factor 4E-binding protein 1 (4E-BP

37 The eukaryotic initiation factor 4E-binding protein 1 (4E-BP

38 Here we show that deletion of the eukaryotic initiation factor 4E-binding protein 1 (4E-BP

39 d induced the phosphorylation of p70S6K1 and eukaryotic initiation factor 4E-binding protein 1 (4E-BP

40 , eukaryotic elongation factor 2 (eEF2), and eukaryotic initiation factor 4E-binding protein 1 (4E-BP

41 active mutant of the translational repressor eukaryotic initiation factor 4E-binding protein 1 (4E-BP

42 mTOR)/p70 ribosomal protein S6 kinase (S6K1)/eukaryotic initiation factor 4E-binding protein 1 (4E-BP

43 This effect was dependent on expression of eukaryotic initiation factor 4E-binding protein 1 (4E-BP

44 g the downstream translational repression of eukaryotic initiation factor 4E-binding protein 1 (4E-BP

45 rget of rapamycin to its downstream targets: eukaryotic initiation factor 4E-binding protein 1 (4E-BP

46 athways of p70 ribosomal S6 kinase (p70S6K), eukaryotic initiation factor 4E-binding protein 1 (4EBP1

47 rEC showed selective increased expression of eukaryotic initiation factor 4E-binding protein 1 (4EBP1

48 these hearts restored 70-kDa S6 kinase 1 and eukaryotic initiation factor 4E-binding protein 1 phosph

49 , reductions in Akt, 70-kDa S6 kinase 1, and eukaryotic initiation factor 4E-binding protein 1 phosph

50 ation of the translational regulators 4E-BP1(eukaryotic initiation factor 4E-binding protein 1) and p

51 on factor 4) and its binding protein 4E-BP1 (eukaryotic initiation factor 4E-binding protein 1).

52 on of the negative regulator of translation, eukaryotic initiation factor 4E-binding protein 1, and i

53 d completely suppressed Akt, GSK3beta, mTOR, eukaryotic initiation factor 4E-binding protein 1, and S

54 n of the ribosomal protein S6 kinase and the eukaryotic initiation factor 4E-binding protein 1, two d

55 activity of p70(s6k) and phosphorylation of eukaryotic initiation factor 4E-binding protein 1, were

56 ng to the phosphorylation of S6 kinase 1 and eukaryotic initiation factor 4E-binding protein 1, which

57 2A with both ribosomal subunit S6-kinase and eukaryotic initiation factor 4E-binding protein 1.

58 t significantly alter the phosphorylation of eukaryotic initiation factor 4E-binding protein 1.

59 ng protein interacting protein 2 (Paip2) and eukaryotic initiation factor 4E-binding protein 2 (4E-BP

60 egulator of mRNA translation initiation, the eukaryotic initiation factor 4E-binding protein 2, leads

61 dissociation of the translational repressor eukaryotic initiation factor 4E-binding protein from the

62 4EBP1 (properties of heat and acid stability/eukaryotic initiation factor 4E-binding protein) and aut

63 d in part through the phosphorylation of the eukaryotic initiation factor 4E-binding protein, PHAS-I.

64 n S6 kinase (p70s6k) and the function of the eukaryotic initiation factor 4E-binding protein-1 (4E-BP

65 ncrease in ribosomal protein S6 kinase 1 and eukaryotic initiation factor 4E-binding protein-1 (4E-BP

66 R signaling phosphoproteins, including mTOR, eukaryotic initiation factor 4E-binding protein-1, p70S6

67 phorylation of ribosomal S6 kinase (S6K) and eukaryotic initiation factor 4E-binding protein-1, two k

68 The eukaryotic initiation factor 4E-binding protein-2 (4E-BP

69 ned the expression and distribution of mTOR, eukaryotic initiation factor 4E-binding protein1/2 (4E-B

70 via the phosphorylation and inactivation of eukaryotic initiation factor 4E-binding proteins (4E-BPs

71 is controlled by the translation inhibitors, Eukaryotic initiation factor 4E-binding proteins (4E-BPs

72 se include translational repressor proteins (eukaryotic initiation factor 4E-binding proteins, 4E-BPs

73 esion kinase, mammalian target of rapamycin, eukaryotic initiation factor-4E-binding protein-1, and r

74 slational signaling pathway, including mTOR, eukaryotic initiation factor-4E-binding proteins 1 and 2

75 of translation p70S6 kinase (S6K) and of the eukaryotic initiation factor 4E-BP1 binding protein (4E-

76 Reduction of cellular eukaryotic initiation factor-4E by RNA interference decr

77 prehensively capture and quantify the eIF4E (eukaryotic initiation factor 4E) 'cap-ome' and apply it

78 d mRNAs is inhibited by dephosphorylation of eukaryotic initiation factor 4E (eIF-4E) (cap-binding pr

79 tion of the translation initiation proteins, eukaryotic initiation factor 4E (eIF-4E) and 4E-binding

80 In BAEC, TNF promotes phosphorylation of eukaryotic initiation factor 4E (eIF-4E), c-Jun N-termin

81 The eukaryotic initiation factor 4E (eIF-4E)-binding protein

82 ascade leading to the phosphorylation of the eukaryotic initiation factor-4E (eIF-4E) binding protein

83 e its deactivation and dissociation from the eukaryotic initiation factor-4E (eIF-4E) complex.

84 IF4E-binding protein 1 (4E-BP1) binds to the eukaryotic initiation factor-4E (eIF-4E), preventing for

85 in vitro kinase activity toward a substrate, eukaryotic initiation factor-4E (eIF-4E).

86 (eIF2alpha Ser51; -20 +/- 5%, P < 0.05) and eukaryotic initiation factor 4E (eIF4E Ser209; +33 +/- 1

87 endent translation by forming a complex with eukaryotic initiation factor 4E (eIF4E) (eIF4E*4E-BP1).

88 This step is initiated by eukaryotic initiation factor 4E (eIF4E) (the m7GTP cap-b

89 Eukaryotic initiation factor 4E (eIF4E) also binds to th

90 programs that are sensitive to depletion of eukaryotic initiation factor 4E (eIF4E) and phosphorylat

91 For instance, the interaction between the eukaryotic initiation factor 4E (eIF4E) and viral protei

92 proliferation via the translation regulators eukaryotic initiation factor 4E (eIF4E) binding protein

93 ranslation in part by phosphorylation of the eukaryotic initiation factor 4E (eIF4E) binding protein

94 a mediates induction of VEGF expression in a eukaryotic initiation factor 4E (eIF4E) binding protein

95 hosphorylation of p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein

96 s not mediated by reduced phosphorylation of eukaryotic initiation factor 4E (eIF4E) binding protein

97 Here, we describe a new eukaryotic initiation factor 4E (eIF4E) binding protein,

98 nases 1 and 2 (S6K1/2) and inhibition of the eukaryotic initiation factor 4E (eIF4E) binding proteins

99 ing pathways enhanced polysome occupancy and eukaryotic initiation factor 4E (eIF4E) binding to the 5

100 Eukaryotic initiation factor 4E (eIF4E) binds to the 7-m

101 mediated by a 5' cap structure to which the eukaryotic initiation factor 4E (eIF4E) binds.

102 We demonstrate that eukaryotic initiation factor 4E (eIF4E) directly binds t

103 Surprisingly, Shh promoted eukaryotic initiation factor 4E (eIF4E) expression, but

104 Two human eukaryotic initiation factor 4E (eIF4E) genes were isola

105 Eukaryotic initiation factor 4E (eIF4E) has long been kn

106 Elevated levels of phosphorylated eukaryotic initiation factor 4E (eIF4E) have been implic

107 The translational factor eukaryotic initiation factor 4E (eIF4E) is a central com

108 The m(7)G cap binding protein eukaryotic initiation factor 4E (eIF4E) is a rate-limiti

109 Furthermore, eukaryotic initiation factor 4E (eIF4E) is localized wit

110 Elevated eukaryotic initiation factor 4E (eIF4E) levels frequentl

111 h, in turn, regulates phosphorylation of the eukaryotic initiation factor 4E (eIF4E) on Ser-209.

112 ective of this study is to determine if high eukaryotic initiation factor 4E (eIF4E) overexpression (

113 Thus, AR suppressed eukaryotic initiation factor 4E (eIF4E) phosphorylation,

114 The eukaryotic initiation factor 4E (eIF4E) plays a central

115 Eukaryotic initiation factor 4E (eIF4E) plays an importa

116 We previously found that overexpressed eukaryotic initiation factor 4E (eIF4E) rescues cells fr

117 Eukaryotic initiation factor 4E (eIF4E) serves as a regu

118 tein kinase interacting kinases 1/2 (MNK1/2)-eukaryotic initiation factor 4E (eIF4E) signaling axis p

119 ) resulted in redistribution of the critical eukaryotic initiation factor 4E (eIF4E) to an mRNA granu

120 Hypoxic cells switch from eukaryotic initiation factor 4E (eIF4E) to eIF4E2 cap-de

121 in translation initiation is the binding of eukaryotic initiation factor 4E (eIF4E) to the 5' mRNA c

122 tiation of translation is the binding of the eukaryotic initiation factor 4E (eIF4E) to the cap struc

123 In vitro, the overexpression of eukaryotic initiation factor 4E (eIF4E) up-regulates the

124 te the phosphorylation and activation of the eukaryotic initiation factor 4E (eIF4E), a protein that

125 h biotin and an orthosteric inhibitor of the eukaryotic initiation factor 4E (eIF4E), an enzyme invol

126 of Pea enation mosaic virus (PEMV) binds to eukaryotic initiation factor 4E (eIF4E), but how this af

127 machinery, SFV reduces levels of translation eukaryotic initiation factor 4E (eIF4E), diminishes phos

128 interaction among initiation factors such as eukaryotic initiation factor 4E (eIF4E), eIF4A, and eIF4

129 tional function of SLBP genetically required eukaryotic initiation factor 4E (eIF4E), eIF4G, and eIF3

130 importance is the complex between cap-bound eukaryotic initiation factor 4E (eIF4E), eIF4G, and poly

131 n of 4E-BP1, a repressor binding protein for eukaryotic initiation factor 4E (eIF4E), that was depend

132 In contrast, eukaryotic initiation factor 4E (eIF4E), the essential m

133 of PHAS-I with the mRNA cap-binding protein, eukaryotic initiation factor 4E (eIF4E), were investigat

134 The eukaryotic initiation factor 4E (eIF4E), when dysregulat

135 egulates the p70S6 kinase (p70(S6k)) and the eukaryotic initiation factor 4E (eIF4E)-binding protein

136 (CDK1/CYCB1) to directly hyperphosphorylate eukaryotic initiation factor 4E (eIF4E)-binding protein

137 Deletion of the eukaryotic initiation factor 4E (eIF4E)-binding protein

138 mTORC1 phosphorylates eukaryotic initiation factor 4E (eIF4E)-binding protein

139 ression of constitutively hypophosphorylated eukaryotic initiation factor 4E (eIF4E)-binding protein

140 Moreover, downregulation of eukaryotic initiation factor 4E (eIF4E)-binding protein

141 The eukaryotic initiation factor 4E (eIF4E)-binding protein,

142 /3 (4EBP), which inhibits the translation of eukaryotic initiation factor 4E (eiF4E)-bound mRNAs.

143 ian capped mRNAs is achieved through the cap-eukaryotic initiation factor 4E (eIF4E)-eIF4G-eIF3-40S c

144 major product in a subtraction library from eukaryotic initiation factor 4E (eIF4E)-transformed cell

145 anism involving recognition of the 5' cap by eukaryotic initiation factor 4E (eIF4E).

146 ls initiation of translation through binding eukaryotic initiation factor 4E (eIF4E).

147 of PHAS-I and on the affinity of PHAS-I for eukaryotic initiation factor 4E (eIF4E).

148 ulated by interaction between PHAS-I and the eukaryotic initiation factor 4E (eIF4E).

149 r its deactivation and dissociation from the eukaryotic initiation factor-4E (eIF4E) complex.

150 R results in dissociation of 4E-BP1 from the eukaryotic initiation factor-4E (eIF4E) complex.

151 3 kinase or blocking the interaction between eukaryotic initiation factors 4E (eIF4E) and 4G (eIF4G)

152 The mRNA cap-binding protein (eukaryotic initiation factor 4E [eIF4E]) binds the m7 Gp

153 associated with increased phosphorylation of eukaryotic initiation factor 4E (elF-4E) and the transla

154 Here, we demonstrate that PML and the eukaryotic initiation factor 4E (elF-4E) co-localize and

155 NFAT, and translation factors, specifically eukaryotic initiation factor 4E (elf4E) and S6 ribosomal

156 AS-I in sites that control PHAS-I binding to eukaryotic initiation factor 4E; however, whether mTOR d

157 (mTOR), and it prevents the dissociation of eukaryotic initiation factor 4E protein (eIF4E) from 4E-

158 E-binding protein from the initiation factor eukaryotic initiation factor 4E, such as 5-fluorouracil,

159 Total eIF4E binding protein 1 and eukaryotic initiation factor 4E were expressed in 13 of

160 e channel itself, releasing both from eIF4E (eukaryotic initiation factor 4E), where they normally in