ライフサイエンスコーパス: eventually develop

1 centage of animals in which mature cataracts eventually develop.

2 inoma patients, progression during treatment eventually develops.

3 els continued to increase and brain swelling eventually developed.

4 an to improve current influenza vaccines and eventually develop a "universal" influenza vaccine.

5 Most mice eventually developed a fatal illness characterized by ma

6 However, these mice eventually developed a late-onset neurologic disease bec

7 The Dll4-overexpressing mice eventually developed a lethal phenotype that was charact

8 %) experienced deep venous thrombosis, and 1 eventually developed a major pulmonary embolus.

9 nical phenotype (18 of 21), but all patients eventually developed a social comportment disorder.

10 of CD5(+) B cell clones, with the elder mice eventually developing a chronic lymphocytic leukemia (CL

11 nt and ~50% of patients whose tumors respond eventually develop acquired resistance (AR).

12 the small percentage of individuals who will eventually develop active disease, complicate the estima

13 proximately 30% of transgene-expressing mice eventually developed acute myeloid leukemia after a long

14 ia, the preclinical phenotype of infants who eventually develop AD is less well-characterized.

15 hGH recipients who did not die from iCJD may eventually develop AD.

16 or MLR inhibition was seen, and most animals eventually developed alloantibody.

17 Half of the CMV viremic patients eventually developed allograft cirrhosis as compared wit

18 Most Down syndrome (DS) individuals eventually develop Alzheimer's disease (AD)-like dementi

19 redicting which nondemented individuals will eventually develop Alzheimer's disease, although here ag

20 ective analysis was performed of 111 men who eventually developed AMD and 401 men who remained free o

21 However, all desensitized animals eventually developed AMR and graft failure.

22 , all mice deficient in both IRF-4 and IRF-8 eventually develop and die of a B-lymphoblastic leukemia

23 Only two patients eventually developed apraxia of speech, while parkinsoni

24 KO) lung tumors that initially responded but eventually developed AR to anti-PD-1, alone or in combin

25 The patches of sensory hair cells that eventually develop are few and small.

26 ipients and 6 lung transplant recipients who eventually developed BOS.

27 All surviving mice eventually developed both cholangiocellular and hepatoce

28 ar infections, delayed motor milestones, and eventually develop bowed legs and lumbar lordosis.

29 0% of patients with metastatic breast cancer eventually developing brain metastases.

30 urdles, a subset of HIV-infected individuals eventually develop broadly neutralizing antibodies that

31 vival without rejection (1258 +/- 388 d), 12 eventually developed CAMR (932 +/- 155 d), and 8 develop

32 patients initially respond to ADT, most will eventually develop castrate resistance, defined as disea

33 ially respond to ADT well, most of them will eventually develop castration-resistant PCa (CRPC).

34 T), the majority of prostate cancer patients eventually develop castration-resistant prostate cancer

35 n therapy (ADT); however, many patients will eventually develop castration-resistant prostate cancer

36 ffective at regressing tumors, most patients eventually develop castration-resistant prostate cancer

37 well controlled in some animals, but others eventually developed CD20(+) diffuse large B cell lympho

38 epatitis B (CHB) carry a significant risk to eventually develop cirrhotic liver disease.

39 However, most of these patients eventually develop clinical resistance to imatinib and o

40 Most people with Parkinson disease (PD) eventually develop cognitive impairment (CI).

41 mean 7 year period between participants who eventually developed cognitive impairment (n = 22) and t

42 owel disease, in which up to 10% of patients eventually develop colon cancer.

43 s correctly classified 12 of 15 patients who eventually developed colon cancer and 15 of 18 who did n

44 ents that developed only anti-B cell IgG ADA eventually developed CR over two years following discont

45 n serum before DAA treatment of patients who eventually developed de novo HCC compared with controls.

46 ever, almost all patients receiving levodopa eventually develop debilitating involuntary movements (d

47 Four hundred ninety-four individuals eventually developed dementia and 427 (86%) of these per

48 ance and impaired glucose tolerance, and 20% eventually develop diabetes.

49 ghout the study, with only 10% of these mice eventually developing diabetes compared to 95% in the co

50 ibitors, but patients with metastatic cancer eventually develop disease progression.

51 essation, provide symptomatic treatment, and eventually develop disease-modifying treatments.

52 ts with constitutively active EGFR mutations eventually develop drug resistance against EGFR tyrosine

53 However, patients treated with CDK4/6i eventually develop drug resistance and progress.

54 inical improvement, the majority of patients eventually develop drug resistance and relapse.

55 survive the competition with other cells and eventually develop drug resistance is a long-standing pa

56 rs that initially respond to PARP inhibitors eventually develop drug resistance.

57 tients with advanced GIST, but most patients eventually develop drug resistance.

58 Unfortunately, the majority of patients eventually develop drug-resistant disease.

59 In the group that eventually developed dysfunction there was less cardiac

60 in understanding the mechanisms of life and eventually developing efficient therapies to treat and c

61 However, most patients eventually develop Enz resistance that may involve induc

62 Moreover, deficient male mice eventually developed equally severe lupus-like disease a

63 Using this model, 80% of individuals who eventually developed ESRD were among the 5% of cohort me

64 Nevertheless, Tag+ tumors eventually develop, evidencing significantly reduced B7.

65 developed was compared between sectors that eventually developed exudative MNV and those that did no

66 s with age-related macular degeneration that eventually developed exudative MNV followed with sequent

67 ard deviation) ORL thickness of sectors that eventually developed exudative MNV was similar to that o

68 Nevertheless, all of these animals eventually developed fatal malignancies.

69 Pfp-->F1 mice eventually developed features of chronic GVHD, such as i

70 ce using KL as a growth factor, the cultures eventually developed from a mixture of WASP-positive and

71 ; however, a maladaptive microglial response eventually develops, fueling a feed-forward spread of ta

72 Under these conditions, many cases eventually develop genetic abnormalities endowing them w

73 Some CoBS-treated animals did eventually develop GVHD, with both clinical and histopat

74 Patients in whom TBM-IRIS eventually developed had significantly more abundant neu

75 ed into newborn mice, almost all of the mice eventually developed hematopoietic malignancies, with a

76 develop iron overload, with up to 10% to 33% eventually developing hemochromatosis-associated morbidi

77 All peptide-immunized mouse strains eventually develop high titers of specific anti-peptide

78 pients, long-term heart allograft recipients eventually developed humoral and cellular immunity again

79 n's disease patients will receive l-DOPA and eventually develop hyperkinetic involuntary movements te

80 15-week-old virgin WAP-CR-1 female mice that eventually developed hyperplastic lesions.

81 However, injured H2-K1 cells eventually develop impaired self-renewal with features o

82 splant lymphoproliferative disorders (PTLD), eventually develop in 2-5% of organ transplant recipient

83 Cataracts eventually develop in 87% of ephrin-A5 KO mice.

84 sease can ultimately lead to relapses, which eventually develop in most patients.

85 beit in reduced numbers, and pigmented cells eventually develop in nearly normal numbers both in cult

86 er, granuloma assembly in parasitized tissue eventually developed in both hosts but with divergent ef

87 The tumors that eventually developed in the TGF-alpha/Bcl-2 double trans

88 The lymphomas and sarcomas that eventually developed in Trp53(515C/515C) mice retained a

89 e began to emerge after 8 months of therapy, eventually developing in 14 patients, including 76% of h

90 (ADT), castration-resistant prostate cancer eventually develops in most men.

91 However, ADI resistance eventually develops in tumors because of AS upregulation

92 However, resistance eventually develops in virtually all patients, and vario

93 While circuits eventually develop, in vivo imaging reveals that spine m

94 However, patients receiving ADT eventually develop incurable castration-resistant prosta

95 nels originate from the particle surface and eventually develop inside the entire product, resulting

96 ubjects with type 1 diabetes mellitus (T1DM) eventually develop insulin resistance and other features

97 h wild-type (WT) and IL-2-KO, and these mice eventually develop intestinal inflammation.

98 0%-50% of patients with Crohn's disease (CD) eventually develop intestinal strictures, with intestina

99 es a fertilized egg decode its own genome to eventually develop into a mature animal?

100 ytes into actively dividing tumor cells that eventually develop into a papillary craniopharyngioma-li

101 from Kupffer cells to hepatocytes where they eventually develop into exoerythrocytic schizonts.

102 pylori infection, and this acquired MALT may eventually develop into low-grade B-cell MALT lymphoma.

103 generate lineage-restricted progenitors that eventually develop into peripheral, postmitotic monocyte

104 erized by fibrosing nodular lesions that may eventually develop into progressive massive fibrosis (PM

105 ntal epithelium, form multiple branches, and eventually develop into supernumerary teeth.

106 ells gives rise to larger cell clusters that eventually develop into the biofilm, a three-dimensional

107 anogaster into several territories that will eventually develop into the compound eye, ocelli, head e

108 The GLI1(+) interstitial cells eventually develop into two cell lineages: steroid-produ

109 Surprisingly, all adenocarcinomas eventually developed into definitive uterine carcinosarc

110 nd subthreshold symptoms of psychosis, which eventually developed into first-rank psychotic symptoms.

111 l oral ectoderm to form an ectopic fold that eventually develops into a separate second pituitary wit

112 ized anxiety usually precedes depression and eventually develops into depression, these findings show

113 in CD30 but deficient in OX40 signals still eventually develop lethal disease.

114 T-bet(-/-) mice were highly susceptible and eventually developed liver inflammation.

115 identified HIV-positive subjects that would eventually develop lymphoma (area under the curve, 82%;

116 features may be at especially high risk for eventually developing mania.

117 the metastatic tumor burden in animals that eventually developed metastases.

118 arcinoma (SCC), with three of the dogs (75%) eventually developing metastatic SCC, an extremely rare

119 He eventually developed mononeuritis multiplex.

120 ese regulatory CRI first appear in mice that eventually develop MSS, sera from infected animals were

121 In mice that eventually developed MSS, CRI were detected by 5 to 6 wk

122 (HIV) worldwide, 40-60% of individuals will eventually develop neurocognitive sequelae that can be a

123 parasite-specific antibody, but the mice did eventually develop normal levels of parasite-specific an

124 al macrophage activation syndrome (of whom 2 eventually developed overt macrophage activation syndrom

125 itive to platinum compounds, such carcinomas eventually develop platinum resistance.

126 ng frontline platinum-based chemotherapy and eventually develop platinum-resistant or platinum-refrac

127 inal image pairs were taken from infants who eventually developed plus disease.

128 dergo surgery for these cancers, 30-35% will eventually develop potentially fatal metachronous distan

129 ndothelial function is impaired in women who eventually develop pre-eclampsia and it occurs before th

130 dilation but only in the group of women who eventually developed pre-eclampsia (r=-0.8, p=0.005).

131 10 levels in first trimester sera from women eventually developing preeclampsia compared with control

132 is crucial to addressing knowledge gaps and eventually developing preventive policies.

133 10(7); however, all of the bioassay hamsters eventually developed prion disease.

134 life for some cancer patients, the majority eventually develop progressive disease after initially r

135 not all patients respond, and many patients eventually develop progressive disease to daratumumab mo

136 vals from frozen serum samples of 40 men who eventually developed prostate cancer and 272 men without

137 protein compared to littermate controls, and eventually developed prostatic intraepithelial neoplasia

138 Up to 30% of people with PsV eventually develop psoriatic arthritis (PsA), an inflamm

139 Twelve of the CHR participants eventually developed psychosis.

140 have RA-related autoantibodies and that many eventually develop RA has led to palindromic rheumatism

141 beta peptides (Abeta), it may be possible to eventually develop radioligands that cross the blood-bra

142 men diagnosed with epithelial ovarian cancer eventually develop recurrence, which rapidly evolves int

143 Some patients eventually develop recurrent or metastatic diseases and

144 skin allografts, but again most animals have eventually developed rejection after prolonged periods o

145 All MR1-treated CD8-/- recipients eventually developed rejection.

146 However, most patients eventually develop resistance and discontinue treatment,

147 The majority of patients, however, will eventually develop resistance and succumb to the disease

148 wledge on how bacteria evade antibiotics and eventually develop resistance could open avenues for nov

149 F(V600E) cutaneous metastatic melanoma (CMM) eventually develop resistance to BRAF inhibitors.

150 these remarkable initial responses, cancers eventually develop resistance to crizotinib, usually wit

151 r 2 (HER2)-positive metastatic breast cancer eventually develop resistance to dual-antibody therapy w

152 However, the vast majority of patients eventually develop resistance to imatinib treatment, lea

153 ologic malignancies, but almost all patients eventually develop resistance to IMiDs.

154 ion of CCR4 in these diseases, most patients eventually develop resistance to mogamulizumab.

155 However, most patients eventually develop resistance to PARPis, highlighting an

156 Most patients with metastatic cancer eventually develop resistance to systemic therapy, with

157 However, patients on vemurafenib eventually develop resistance to the drug and demonstrat

158 mours (GIST), but almost all metastatic GIST eventually develop resistance to these agents, resulting

159 However, most patients eventually develop resistance to these therapies, unders

160 ates transient effects because many patients eventually develop resistance to this treatment.

161 cell lung cancer (NSCLC), most patients will eventually develop resistance to TKIs.

162 ajority of these tumors relapse and patients eventually develop resistance to TKIs.

163 However, most patients eventually develop resistance to treatment through a mec

164 2-) metastatic breast cancer (MBC), patients eventually develop resistance, and eventually most will

165 y in several cancers; however, most patients eventually develop resistance.

166 s adapt to KIT/PDGFRA driver suppression and eventually develop resistance.

167 ted therapy and immunotherapy, many patients eventually develop resistance.

168 mutated lung cancers; however, most patients eventually develop resistance.

169 ibitors, and of the 70% that do respond, all eventually develop resistance.

170 ently because patients with advanced disease eventually develop resistance.

171 th factor receptor (EGFR)-targeted therapies eventually develop resistance.

172 ing advanced stages of breast cancers, women eventually develop resistance.

173 In human GISTs that eventually developed resistance to imatinib, TAMs revert

174 lung tumor growth and metastasis, but tumors eventually developed resistance to sustained combinatori

175 With therapy, some patients eventually develop resistant CLL or transformation to an

176 respond to the T/HCQ regimen, and Patient 1 eventually developed resistant disease.

177 ants may first present features of STGD1 but eventually develop rod dysfunction, and specific missens

178 okine modifiers are of primary importance in eventually developing safe and effective means of treatm

179 roportion of patients treated with etoposide eventually develop secondary leukemias that are characte

180 that a small percentage of patients with CLE eventually develop SLE and that even if they do, most pa

181 clinical responses, the majority of patients eventually develop some degree of resistance to Taxol-ba

182 almost all patients with dysthymic disorder eventually develop superimposed major depressive episode

183 rations (15.9 [11.1 to 23.5] mo); nearly all eventually developed symptoms and ended in treatment or

184 to identify key drivers of tumorigenesis to eventually develop targeted therapies to enhance cure ra

185 all 3 patients, acute myeloid leukemia (AML) eventually developed that had similar characteristics an

186 ected individuals in the population who will eventually develop the disease, mainly in endemic countr

187 All individuals with Down syndrome (DS) eventually develop the neuropathology of Alzheimer's dis

188 erior ischemic optic neuropathy (NAION) will eventually develop the same condition in their other eye

189 acquired immunodeficiency syndrome patients eventually develop this condition, and at present it rem

190 stance to targeted drugs, but resistance may eventually develop to combinatorial therapies.

191 or do new ecological and evolutionary forces eventually develop to limit their populations?

192 initial response rates, almost all patients eventually develop treatment resistance to EGFR tyrosine

193 ited megamitochondria, and older mutant mice eventually developed tubulointerstitial renal disease.

194 it elevated lipid levels at an early age and eventually develop type 2 diabetes.